Motif 52 (n=160)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0AV02 | SLC12A8 | S665 | ochoa | Solute carrier family 12 member 8 (Cation-chloride cotransporter 9) | Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}. |
A4FU49 | SH3D21 | S269 | ochoa | SH3 domain-containing protein 21 | None |
A6NDB9 | PALM3 | S72 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
A8MUU9 | None | S321 | ochoa | Putative uncharacterized protein ENSP00000383309 | None |
B8ZZF3 | None | S369 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
H3BRB1 | None | S238 | ochoa | polynucleotide adenylyltransferase (EC 2.7.7.19) | None |
O14647 | CHD2 | S1789 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
O15265 | ATXN7 | S571 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
O60266 | ADCY3 | S525 | ochoa | Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}. |
O60336 | MAPKBP1 | S488 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
O75030 | MITF | S180 | psp | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}. |
O75376 | NCOR1 | S1281 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
O75427 | LRCH4 | S281 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
O75444 | MAF | S70 | psp | Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) | Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. {ECO:0000250, ECO:0000269|PubMed:12149651, ECO:0000269|PubMed:14998494, ECO:0000269|PubMed:15007382, ECO:0000269|PubMed:16247450, ECO:0000269|PubMed:19143053}. |
O94806 | PRKD3 | S543 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
O94887 | FARP2 | S876 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
O95155 | UBE4B | S238 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
O95359 | TACC2 | S1635 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
O95398 | RAPGEF3 | S864 | ochoa | Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}. |
O95402 | MED26 | S361 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
O95613 | PCNT | S2214 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
O95758 | PTBP3 | S56 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
P10244 | MYBL2 | S452 | ochoa|psp | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
P15822 | HIVEP1 | S1158 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
P15822 | HIVEP1 | S2297 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
P17535 | JUND | S43 | ochoa | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}. |
P17535 | JUND | S90 | ochoa | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}. |
P18146 | EGR1 | S26 | ochoa|psp | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) | Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
P19532 | TFE3 | S246 | psp | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. |
P19634 | SLC9A1 | S726 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
P23771 | GATA3 | S162 | ochoa|psp | Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P23772, ECO:0000269|PubMed:23824597}. |
P27361 | MAPK3 | S263 | ochoa | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) (PubMed:35216969). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. {ECO:0000269|PubMed:10393181, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:34497368, ECO:0000269|PubMed:35216969, ECO:0000269|PubMed:8325880, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9480836}. |
P29353 | SHC1 | S54 | psp | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
P35712 | SOX6 | S442 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
P42226 | STAT6 | S756 | psp | Signal transducer and activator of transcription 6 (IL-4 Stat) | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218}. |
P43354 | NR4A2 | S256 | ochoa | Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}. |
P46019 | PHKA2 | S735 | ochoa | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
P47974 | ZFP36L2 | S448 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
P48378 | RFX2 | S28 | ochoa | DNA-binding protein RFX2 (Regulatory factor X 2) | Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:10330134}. |
P48552 | NRIP1 | S807 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
P49642 | PRIM1 | S310 | ochoa | DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) | Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed:17893144, PubMed:24043831, PubMed:25550159, PubMed:26975377, PubMed:31479243, PubMed:33060134, PubMed:9268648, PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs) (PubMed:26975377). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end (PubMed:25550159, PubMed:26975377). Binds single stranded DNA (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:33060134, ECO:0000269|PubMed:9268648, ECO:0000269|PubMed:9705292}. |
P54821 | PRRX1 | S21 | ochoa | Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). {ECO:0000250|UniProtKB:P63013, ECO:0000269|PubMed:35589735}.; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. {ECO:0000250|UniProtKB:P63013}.; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. {ECO:0000250|UniProtKB:P63013}. |
P54868 | HMGCS2 | S433 | ochoa | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}. |
P57682 | KLF3 | S224 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
P78413 | IRX4 | S430 | ochoa | Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) | Likely to be an important mediator of ventricular differentiation during cardiac development. |
P78524 | DENND2B | S539 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
Q05932 | FPGS | S539 | ochoa | Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}. |
Q05D32 | CTDSPL2 | S134 | ochoa|psp | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
Q06203 | PPAT | S399 | ochoa | Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) | Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. {ECO:0000250|UniProtKB:P35433}. |
Q07157 | TJP1 | S968 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q08174 | PCDH1 | S949 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
Q12772 | SREBF2 | S469 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
Q12772 | SREBF2 | S1046 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
Q12851 | MAP4K2 | S298 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
Q13233 | MAP3K1 | S1018 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
Q14139 | UBE4A | S551 | ochoa | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}. |
Q15735 | INPP5J | S150 | ochoa | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56) | Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. {ECO:0000250|UniProtKB:Q9JMC1}. |
Q15788 | NCOA1 | S325 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
Q15788 | NCOA1 | S1279 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
Q16236 | NFE2L2 | S577 | psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
Q17RY0 | CPEB4 | S340 | ochoa | Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4) | Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}. |
Q4VCS5 | AMOT | S200 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
Q5JPH6 | EARS2 | S143 | ochoa | Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS) | Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation (PubMed:19805282). Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln) (PubMed:19805282). In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity (PubMed:19805282). {ECO:0000269|PubMed:19805282}. |
Q5TCZ1 | SH3PXD2A | S662 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
Q5VUB5 | FAM171A1 | S525 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
Q66K74 | MAP1S | S731 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
Q6BDS2 | BLTP3A | S928 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
Q6IMN6 | CAPRIN2 | S660 | ochoa | Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) | Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). {ECO:0000250|UniProtKB:Q05A80, ECO:0000269|PubMed:14593112, ECO:0000269|PubMed:18762581, ECO:0000269|PubMed:27821587}. |
Q6MZQ0 | PRR5L | S29 | ochoa | Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) | Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}. |
Q6NUJ5 | PWWP2B | S60 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
Q6S5L8 | SHC4 | S132 | ochoa|psp | SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) | Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}. |
Q6UB99 | ANKRD11 | S1509 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q6WBX8 | RAD9B | S282 | ochoa | Cell cycle checkpoint control protein RAD9B (DNA repair exonuclease rad9 homolog B) (hRAD9B) | None |
Q70E73 | RAPH1 | S54 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Q70EL1 | USP54 | S1286 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
Q7Z3V4 | UBE3B | S419 | ochoa | Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes (By similarity). Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC (By similarity). {ECO:0000250|UniProtKB:Q9ES34}. |
Q7Z569 | BRAP | S117 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
Q7Z5H3 | ARHGAP22 | S359 | ochoa|psp | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
Q7Z6G3 | NECAB2 | S57 | ochoa | N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2) | May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}. |
Q86TG7 | PEG10 | S252 | ochoa | Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein) | Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity). {ECO:0000250|UniProtKB:Q7TN75, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:26235627, ECO:0000269|PubMed:28193232, ECO:0000269|PubMed:30094509, ECO:0000269|PubMed:34413232}. |
Q86UW9 | DTX2 | S360 | ochoa | Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
Q86X10 | RALGAPB | S921 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Q86Y97 | KMT5C | S439 | ochoa | Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q6Q783, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}. |
Q8IW19 | APLF | S131 | ochoa | Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | Histone chaperone involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:21211722, PubMed:29905837, PubMed:30104678). Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:30104678). Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:21211722, PubMed:29905837, PubMed:30104678). Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (PubMed:17353262, PubMed:17396150). Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721, PubMed:23689425). Also acts as a negative regulator of cell pluripotency by promoting histone exchange (By similarity). Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity). {ECO:0000250|UniProtKB:Q9D842, ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425, ECO:0000269|PubMed:29905837, ECO:0000269|PubMed:30104678}. |
Q8IWU2 | LMTK2 | S630 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
Q8N3K9 | CMYA5 | S1283 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
Q8N3V7 | SYNPO | S580 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8NBR9 | NDUFV1-DT | S42 | ochoa | Uncharacterized protein NDUFV1-DT (NDUFV1 divergent transcript) | None |
Q8ND82 | ZNF280C | S105 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
Q8NEZ4 | KMT2C | S3519 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
Q8NHV4 | NEDD1 | S215 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
Q8TEK3 | DOT1L | S834 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
Q8TEK3 | DOT1L | S1001 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
Q92466 | DDB2 | S297 | ochoa | DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:32789493, PubMed:9892649). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:14751237, PubMed:16260596, PubMed:32789493). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:16260596). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825). {ECO:0000269|PubMed:10882109, ECO:0000269|PubMed:11278856, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:26572825, ECO:0000269|PubMed:32789493, ECO:0000269|PubMed:9892649}.; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}. |
Q92615 | LARP4B | S398 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
Q92674 | CENPI | S520 | ochoa | Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}. |
Q92817 | EVPL | S1813 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
Q96BD5 | PHF21A | S455 | ochoa | PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269|PubMed:16140033}. |
Q96FZ5 | CMTM7 | S30 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) | None |
Q96HB5 | CCDC120 | S286 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
Q96IF1 | AJUBA | S137 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
Q96JM2 | ZNF462 | S350 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
Q96KB5 | PBK | S32 | ochoa|psp | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
Q96ME7 | ZNF512 | S319 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
Q96P47 | AGAP3 | S443 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1) | GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}. |
Q99081 | TCF12 | S386 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
Q99567 | NUP88 | S517 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
Q99569 | PKP4 | S127 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
Q99640 | PKMYT1 | S416 | psp | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
Q99990 | VGLL1 | S116 | ochoa | Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000269|PubMed:10518497}. |
Q9BRK5 | SDF4 | S209 | ochoa | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
Q9BSQ5 | CCM2 | S164 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
Q9BWN1 | PRR14 | S277 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
Q9BZE0 | GLIS2 | S54 | ochoa | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
Q9C0C2 | TNKS1BP1 | S1297 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0C7 | AMBRA1 | S52 | psp | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
Q9C0H5 | ARHGAP39 | S366 | ochoa | Rho GTPase-activating protein 39 | None |
Q9H0F6 | SHARPIN | S165 | ochoa|psp | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
Q9H0W8 | SMG9 | S451 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
Q9H2J1 | ARRDC1-AS1 | S71 | ochoa | Uncharacterized protein ARRDC1-AS1 (ARRDC1 antisense RNA 1) (ARRDC1 antisense gene protein 1) | None |
Q9H2P0 | ADNP | S363 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
Q9H2Y7 | ZNF106 | S661 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
Q9H2Y7 | ZNF106 | S727 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
Q9H611 | PIF1 | S151 | ochoa | ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}. |
Q9H6E5 | TUT1 | S238 | ochoa | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}. |
Q9H792 | PEAK1 | S898 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
Q9NPG3 | UBN1 | S821 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
Q9NQW6 | ANLN | S182 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
Q9NQW6 | ANLN | S792 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
Q9NRM7 | LATS2 | S342 | ochoa | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
Q9NS56 | TOPORS | S101 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
Q9NWQ4 | GPATCH2L | S447 | ochoa | G patch domain-containing protein 2-like | None |
Q9NWZ5 | UCKL1 | S56 | ochoa | Uridine-cytidine kinase-like 1 (EC 2.7.1.48) | May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}. |
Q9NX95 | SYBU | S396 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
Q9NYJ8 | TAB2 | S372 | ochoa|psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}. |
Q9NYV4 | CDK12 | S644 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
Q9NZ52 | GGA3 | S559 | psp | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
Q9P227 | ARHGAP23 | S554 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
Q9P275 | USP36 | S513 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
Q9P2F5 | STOX2 | S172 | ochoa | Storkhead-box protein 2 | None |
Q9UBB9 | TFIP11 | S568 | ochoa | Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) | Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}. |
Q9UBN7 | HDAC6 | S1035 | psp | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
Q9UF83 | None | S519 | ochoa | Uncharacterized protein DKFZp434B061 | None |
Q9UJU6 | DBNL | S24 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
Q9ULC8 | ZDHHC8 | S743 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
Q9UM47 | NOTCH3 | S2117 | ochoa | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250|UniProtKB:Q9R172, ECO:0000269|PubMed:15350543}. |
Q9UNE0 | EDAR | S297 | ochoa | Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
Q9UNZ2 | NSFL1C | S272 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
Q9UPZ3 | HPS5 | S534 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
Q9Y2H5 | PLEKHA6 | S336 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
Q9Y3M8 | STARD13 | S171 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
Q9Y4B5 | MTCL1 | S1588 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
Q9Y4F1 | FARP1 | S510 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
Q9Y4R8 | TELO2 | S688 | ochoa | Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}. |
Q9Y613 | FHOD1 | S498 | ochoa|psp | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
Q9Y6R4 | MAP3K4 | S1135 | ochoa | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
Q8IZQ8 | MYOCD | S862 | GPS6 | Myocardin | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}. |
Q9UNA1 | ARHGAP26 | S685 | SIGNOR | Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) | GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058). {ECO:0000269|PubMed:27512058, ECO:0000269|PubMed:38081847}.; FUNCTION: [Isoform 2]: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. {ECO:0000269|PubMed:32344433}. |
Q03112 | MECOM | S726 | SIGNOR | Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) | [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}. |
O75928 | PIAS2 | S116 | SIGNOR | E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. {ECO:0000269|PubMed:15920481, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22406621}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.000721 | 3.142 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.001708 | 2.767 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.001804 | 2.744 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.001868 | 2.729 |
R-HSA-2028269 | Signaling by Hippo | 0.001789 | 2.747 |
R-HSA-9830364 | Formation of the nephric duct | 0.000374 | 3.427 |
R-HSA-9842663 | Signaling by LTK | 0.000721 | 3.142 |
R-HSA-166520 | Signaling by NTRKs | 0.000461 | 3.336 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.003520 | 2.453 |
R-HSA-9031628 | NGF-stimulated transcription | 0.003240 | 2.489 |
R-HSA-9634597 | GPER1 signaling | 0.003240 | 2.489 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003432 | 2.465 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.004313 | 2.365 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.004313 | 2.365 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.004626 | 2.335 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.007031 | 2.153 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.007031 | 2.153 |
R-HSA-9707616 | Heme signaling | 0.007054 | 2.152 |
R-HSA-8939211 | ESR-mediated signaling | 0.006770 | 2.169 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.006016 | 2.221 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.006329 | 2.199 |
R-HSA-74749 | Signal attenuation | 0.008751 | 2.058 |
R-HSA-9830369 | Kidney development | 0.008925 | 2.049 |
R-HSA-4839726 | Chromatin organization | 0.008771 | 2.057 |
R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.010079 | 1.997 |
R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.011490 | 1.940 |
R-HSA-1989781 | PPARA activates gene expression | 0.011200 | 1.951 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.011795 | 1.928 |
R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.011490 | 1.940 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.011352 | 1.945 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.013580 | 1.867 |
R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.052013 | 1.284 |
R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.052013 | 1.284 |
R-HSA-8941237 | Invadopodia formation | 0.052013 | 1.284 |
R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.062088 | 1.207 |
R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.062088 | 1.207 |
R-HSA-9652169 | Signaling by MAP2K mutants | 0.062088 | 1.207 |
R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.072057 | 1.142 |
R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.072057 | 1.142 |
R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.072057 | 1.142 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.081920 | 1.087 |
R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.081920 | 1.087 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.081920 | 1.087 |
R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.101336 | 0.994 |
R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.101336 | 0.994 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.110890 | 0.955 |
R-HSA-8875656 | MET receptor recycling | 0.110890 | 0.955 |
R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.120343 | 0.920 |
R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.031991 | 1.495 |
R-HSA-68952 | DNA replication initiation | 0.129696 | 0.887 |
R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.034263 | 1.465 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.036595 | 1.437 |
R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.041437 | 1.383 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.148106 | 0.829 |
R-HSA-202670 | ERKs are inactivated | 0.148106 | 0.829 |
R-HSA-69109 | Leading Strand Synthesis | 0.157166 | 0.804 |
R-HSA-69091 | Polymerase switching | 0.157166 | 0.804 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.049120 | 1.309 |
R-HSA-170660 | Adenylate cyclase activating pathway | 0.166129 | 0.780 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.166129 | 0.780 |
R-HSA-9615710 | Late endosomal microautophagy | 0.054504 | 1.264 |
R-HSA-69166 | Removal of the Flap Intermediate | 0.174998 | 0.757 |
R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.183773 | 0.736 |
R-HSA-180336 | SHC1 events in EGFR signaling | 0.183773 | 0.736 |
R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.201046 | 0.697 |
R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.217956 | 0.662 |
R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.226277 | 0.645 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.258689 | 0.587 |
R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.258689 | 0.587 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.266579 | 0.574 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.176137 | 0.754 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.176137 | 0.754 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.187591 | 0.727 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.214680 | 0.668 |
R-HSA-380287 | Centrosome maturation | 0.222489 | 0.653 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.234244 | 0.630 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.277551 | 0.557 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.166129 | 0.780 |
R-HSA-69186 | Lagging Strand Synthesis | 0.242655 | 0.615 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.250715 | 0.601 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.285426 | 0.545 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.064241 | 1.192 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.064241 | 1.192 |
R-HSA-9646399 | Aggrephagy | 0.090595 | 1.043 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.242655 | 0.615 |
R-HSA-69183 | Processive synthesis on the lagging strand | 0.183773 | 0.736 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.105855 | 0.975 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.064241 | 1.192 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.238171 | 0.623 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.147948 | 0.830 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.176137 | 0.754 |
R-HSA-191650 | Regulation of gap junction activity | 0.062088 | 1.207 |
R-HSA-110056 | MAPK3 (ERK1) activation | 0.129696 | 0.887 |
R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.166129 | 0.780 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.183773 | 0.736 |
R-HSA-174430 | Telomere C-strand synthesis initiation | 0.183773 | 0.736 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.028536 | 1.545 |
R-HSA-198753 | ERK/MAPK targets | 0.242655 | 0.615 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.114087 | 0.943 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.114087 | 0.943 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.114087 | 0.943 |
R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.258689 | 0.587 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.261789 | 0.582 |
R-HSA-9843745 | Adipogenesis | 0.073871 | 1.132 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.036669 | 1.436 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.036669 | 1.436 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.049120 | 1.309 |
R-HSA-3214815 | HDACs deacetylate histones | 0.146227 | 0.835 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.097150 | 1.013 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.093856 | 1.028 |
R-HSA-6802949 | Signaling by RAS mutants | 0.114087 | 0.943 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.113723 | 0.944 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.062088 | 1.207 |
R-HSA-69478 | G2/M DNA replication checkpoint | 0.091680 | 1.038 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.120343 | 0.920 |
R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.129696 | 0.887 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.157166 | 0.804 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.183773 | 0.736 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.192456 | 0.716 |
R-HSA-164378 | PKA activation in glucagon signalling | 0.217956 | 0.662 |
R-HSA-167044 | Signalling to RAS | 0.242655 | 0.615 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.274385 | 0.562 |
R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.297312 | 0.527 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.025557 | 1.592 |
R-HSA-156711 | Polo-like kinase mediated events | 0.025557 | 1.592 |
R-HSA-170968 | Frs2-mediated activation | 0.166129 | 0.780 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.214374 | 0.669 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.289751 | 0.538 |
R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.120343 | 0.920 |
R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.120343 | 0.920 |
R-HSA-8851805 | MET activates RAS signaling | 0.157166 | 0.804 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.174998 | 0.757 |
R-HSA-157118 | Signaling by NOTCH | 0.061583 | 1.211 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.250076 | 0.602 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.179943 | 0.745 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.236254 | 0.627 |
R-HSA-8983432 | Interleukin-15 signaling | 0.157166 | 0.804 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.065464 | 1.184 |
R-HSA-187687 | Signalling to ERKs | 0.074835 | 1.126 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.150448 | 0.823 |
R-HSA-9732724 | IFNG signaling activates MAPKs | 0.101336 | 0.994 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.148106 | 0.829 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.037078 | 1.431 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.242655 | 0.615 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.242655 | 0.615 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.076614 | 1.116 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.082674 | 1.083 |
R-HSA-169893 | Prolonged ERK activation events | 0.192456 | 0.716 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.226277 | 0.645 |
R-HSA-75893 | TNF signaling | 0.149906 | 0.824 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.274385 | 0.562 |
R-HSA-2428924 | IGF1R signaling cascade | 0.042698 | 1.370 |
R-HSA-392517 | Rap1 signalling | 0.226277 | 0.645 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.063684 | 1.196 |
R-HSA-450294 | MAP kinase activation | 0.168565 | 0.773 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.045659 | 1.340 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.217956 | 0.662 |
R-HSA-74752 | Signaling by Insulin receptor | 0.297223 | 0.527 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.044166 | 1.355 |
R-HSA-448424 | Interleukin-17 signaling | 0.203018 | 0.692 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.061927 | 1.208 |
R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.062088 | 1.207 |
R-HSA-9842640 | Signaling by LTK in cancer | 0.091680 | 1.038 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.019730 | 1.705 |
R-HSA-425986 | Sodium/Proton exchangers | 0.110890 | 0.955 |
R-HSA-444257 | RSK activation | 0.110890 | 0.955 |
R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.157166 | 0.804 |
R-HSA-163615 | PKA activation | 0.217956 | 0.662 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.226277 | 0.645 |
R-HSA-429947 | Deadenylation of mRNA | 0.274385 | 0.562 |
R-HSA-9839394 | TGFBR3 expression | 0.282109 | 0.550 |
R-HSA-9612973 | Autophagy | 0.284889 | 0.545 |
R-HSA-69275 | G2/M Transition | 0.070137 | 1.154 |
R-HSA-73886 | Chromosome Maintenance | 0.176152 | 0.754 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.138090 | 0.860 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.072428 | 1.140 |
R-HSA-9663891 | Selective autophagy | 0.277551 | 0.557 |
R-HSA-1266738 | Developmental Biology | 0.103733 | 0.984 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.209546 | 0.679 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.209546 | 0.679 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.022683 | 1.644 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.034263 | 1.465 |
R-HSA-9909396 | Circadian clock | 0.211197 | 0.675 |
R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.138950 | 0.857 |
R-HSA-9005895 | Pervasive developmental disorders | 0.157166 | 0.804 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.157166 | 0.804 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.157166 | 0.804 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.250715 | 0.601 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.112253 | 0.950 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.257848 | 0.589 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.112253 | 0.950 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.112253 | 0.950 |
R-HSA-1236394 | Signaling by ERBB4 | 0.058482 | 1.233 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.289751 | 0.538 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.222489 | 0.653 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.140533 | 0.852 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.170915 | 0.767 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.170915 | 0.767 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.178788 | 0.748 |
R-HSA-180786 | Extension of Telomeres | 0.161052 | 0.793 |
R-HSA-1632852 | Macroautophagy | 0.239107 | 0.621 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.090595 | 1.043 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.178788 | 0.748 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.054504 | 1.264 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.057271 | 1.242 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.074835 | 1.126 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.242655 | 0.615 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.242655 | 0.615 |
R-HSA-9627069 | Regulation of the apoptosome activity | 0.129696 | 0.887 |
R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.166129 | 0.780 |
R-HSA-354192 | Integrin signaling | 0.065854 | 1.181 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.074835 | 1.126 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.201046 | 0.697 |
R-HSA-2160916 | Hyaluronan degradation | 0.282109 | 0.550 |
R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.282109 | 0.550 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.150448 | 0.823 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.158028 | 0.801 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.092678 | 1.033 |
R-HSA-5669034 | TNFs bind their physiological receptors | 0.274385 | 0.562 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.019190 | 1.717 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.261866 | 0.582 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.062947 | 1.201 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.110641 | 0.956 |
R-HSA-190236 | Signaling by FGFR | 0.112253 | 0.950 |
R-HSA-5654743 | Signaling by FGFR4 | 0.017810 | 1.749 |
R-HSA-9635465 | Suppression of apoptosis | 0.138950 | 0.857 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.242655 | 0.615 |
R-HSA-525793 | Myogenesis | 0.289751 | 0.538 |
R-HSA-418555 | G alpha (s) signalling events | 0.147167 | 0.832 |
R-HSA-5654741 | Signaling by FGFR3 | 0.019684 | 1.706 |
R-HSA-1640170 | Cell Cycle | 0.092195 | 1.035 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.099785 | 1.001 |
R-HSA-162582 | Signal Transduction | 0.029659 | 1.528 |
R-HSA-1227986 | Signaling by ERBB2 | 0.037078 | 1.431 |
R-HSA-5654738 | Signaling by FGFR2 | 0.069092 | 1.161 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.124984 | 0.903 |
R-HSA-5654736 | Signaling by FGFR1 | 0.031867 | 1.497 |
R-HSA-77111 | Synthesis of Ketone Bodies | 0.234510 | 0.630 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.157320 | 0.803 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.210785 | 0.676 |
R-HSA-6806834 | Signaling by MET | 0.242102 | 0.616 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.216274 | 0.665 |
R-HSA-8963896 | HDL assembly | 0.174998 | 0.757 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.226277 | 0.645 |
R-HSA-9020558 | Interleukin-2 signaling | 0.138950 | 0.857 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.049120 | 1.309 |
R-HSA-6794361 | Neurexins and neuroligins | 0.135308 | 0.869 |
R-HSA-3371556 | Cellular response to heat stress | 0.176152 | 0.754 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.110890 | 0.955 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.120343 | 0.920 |
R-HSA-9762292 | Regulation of CDH11 function | 0.129696 | 0.887 |
R-HSA-111458 | Formation of apoptosome | 0.129696 | 0.887 |
R-HSA-1502540 | Signaling by Activin | 0.183773 | 0.736 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.149906 | 0.824 |
R-HSA-196757 | Metabolism of folate and pterines | 0.081026 | 1.091 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.039647 | 1.402 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.164801 | 0.783 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.183773 | 0.736 |
R-HSA-445144 | Signal transduction by L1 | 0.234510 | 0.630 |
R-HSA-74182 | Ketone body metabolism | 0.266579 | 0.574 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.074701 | 1.127 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.172344 | 0.764 |
R-HSA-6807070 | PTEN Regulation | 0.233472 | 0.632 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.170915 | 0.767 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.039647 | 1.402 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.148106 | 0.829 |
R-HSA-1181150 | Signaling by NODAL | 0.234510 | 0.630 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.266579 | 0.574 |
R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.297312 | 0.527 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.032906 | 1.483 |
R-HSA-1538133 | G0 and Early G1 | 0.062947 | 1.201 |
R-HSA-9733709 | Cardiogenesis | 0.065854 | 1.181 |
R-HSA-210993 | Tie2 Signaling | 0.217956 | 0.662 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.258689 | 0.587 |
R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.289751 | 0.538 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.203018 | 0.692 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.282109 | 0.550 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.246035 | 0.609 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.261789 | 0.582 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.124587 | 0.905 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.062947 | 1.201 |
R-HSA-8963898 | Plasma lipoprotein assembly | 0.274385 | 0.562 |
R-HSA-201556 | Signaling by ALK | 0.087369 | 1.059 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.164801 | 0.783 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.164801 | 0.783 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.164801 | 0.783 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.164801 | 0.783 |
R-HSA-9006936 | Signaling by TGFB family members | 0.296468 | 0.528 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.107223 | 0.970 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.256147 | 0.592 |
R-HSA-111471 | Apoptotic factor-mediated response | 0.217956 | 0.662 |
R-HSA-982772 | Growth hormone receptor signaling | 0.266579 | 0.574 |
R-HSA-75153 | Apoptotic execution phase | 0.114087 | 0.943 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.164801 | 0.783 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.269670 | 0.569 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.293293 | 0.533 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.298852 | 0.525 |
R-HSA-109581 | Apoptosis | 0.302270 | 0.520 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.304793 | 0.516 |
R-HSA-171319 | Telomere Extension By Telomerase | 0.304793 | 0.516 |
R-HSA-73614 | Pyrimidine salvage | 0.304793 | 0.516 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.312195 | 0.506 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.312195 | 0.506 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.312195 | 0.506 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.312195 | 0.506 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.312195 | 0.506 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.312195 | 0.506 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.312195 | 0.506 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.319519 | 0.496 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.319519 | 0.496 |
R-HSA-2424491 | DAP12 signaling | 0.319519 | 0.496 |
R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.319519 | 0.496 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.319519 | 0.496 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.319519 | 0.496 |
R-HSA-157579 | Telomere Maintenance | 0.320719 | 0.494 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.320719 | 0.494 |
R-HSA-212436 | Generic Transcription Pathway | 0.321362 | 0.493 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.326765 | 0.486 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.326765 | 0.486 |
R-HSA-186763 | Downstream signal transduction | 0.326765 | 0.486 |
R-HSA-3214847 | HATs acetylate histones | 0.328512 | 0.483 |
R-HSA-69190 | DNA strand elongation | 0.333934 | 0.476 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.334242 | 0.476 |
R-HSA-5689880 | Ub-specific processing proteases | 0.337150 | 0.472 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.340156 | 0.468 |
R-HSA-1483255 | PI Metabolism | 0.340156 | 0.468 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.341028 | 0.467 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.341028 | 0.467 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.341028 | 0.467 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.341028 | 0.467 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.341028 | 0.467 |
R-HSA-159418 | Recycling of bile acids and salts | 0.341028 | 0.467 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.341028 | 0.467 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.341028 | 0.467 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.341028 | 0.467 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.341028 | 0.467 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.341028 | 0.467 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.348046 | 0.458 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.348046 | 0.458 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.348046 | 0.458 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.348046 | 0.458 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.348046 | 0.458 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.348046 | 0.458 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.354990 | 0.450 |
R-HSA-180746 | Nuclear import of Rev protein | 0.354990 | 0.450 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.354990 | 0.450 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.354990 | 0.450 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.354990 | 0.450 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.354990 | 0.450 |
R-HSA-2142845 | Hyaluronan metabolism | 0.354990 | 0.450 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.354990 | 0.450 |
R-HSA-5673000 | RAF activation | 0.354990 | 0.450 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.354990 | 0.450 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.354990 | 0.450 |
R-HSA-5683057 | MAPK family signaling cascades | 0.355351 | 0.449 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.355584 | 0.449 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.361860 | 0.441 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.361860 | 0.441 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.361860 | 0.441 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.361860 | 0.441 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.367071 | 0.435 |
R-HSA-8853659 | RET signaling | 0.368658 | 0.433 |
R-HSA-3371511 | HSF1 activation | 0.368658 | 0.433 |
R-HSA-111933 | Calmodulin induced events | 0.368658 | 0.433 |
R-HSA-111997 | CaM pathway | 0.368658 | 0.433 |
R-HSA-9711123 | Cellular response to chemical stress | 0.369983 | 0.432 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.374686 | 0.426 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.374686 | 0.426 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.375384 | 0.426 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.375384 | 0.426 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.375384 | 0.426 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.375384 | 0.426 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.375384 | 0.426 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.382038 | 0.418 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.382038 | 0.418 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.382264 | 0.418 |
R-HSA-5617833 | Cilium Assembly | 0.386359 | 0.413 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.388622 | 0.410 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.388622 | 0.410 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.389232 | 0.410 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.392103 | 0.407 |
R-HSA-68877 | Mitotic Prometaphase | 0.394970 | 0.403 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.395136 | 0.403 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.395136 | 0.403 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.395136 | 0.403 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.395136 | 0.403 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.395136 | 0.403 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.395136 | 0.403 |
R-HSA-451927 | Interleukin-2 family signaling | 0.395136 | 0.403 |
R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.395136 | 0.403 |
R-HSA-8982491 | Glycogen metabolism | 0.395136 | 0.403 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.401034 | 0.397 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.401582 | 0.396 |
R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.401582 | 0.396 |
R-HSA-9694548 | Maturation of spike protein | 0.401582 | 0.396 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.403551 | 0.394 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.407959 | 0.389 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.407959 | 0.389 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.407959 | 0.389 |
R-HSA-9007101 | Rab regulation of trafficking | 0.408468 | 0.389 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.408468 | 0.389 |
R-HSA-991365 | Activation of GABAB receptors | 0.414268 | 0.383 |
R-HSA-977444 | GABA B receptor activation | 0.414268 | 0.383 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.414268 | 0.383 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.414268 | 0.383 |
R-HSA-111996 | Ca-dependent events | 0.414268 | 0.383 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.414938 | 0.382 |
R-HSA-68875 | Mitotic Prophase | 0.419535 | 0.377 |
R-HSA-9710421 | Defective pyroptosis | 0.420510 | 0.376 |
R-HSA-8854214 | TBC/RABGAPs | 0.420510 | 0.376 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 0.420510 | 0.376 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.423201 | 0.373 |
R-HSA-2172127 | DAP12 interactions | 0.426687 | 0.370 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.430497 | 0.366 |
R-HSA-68886 | M Phase | 0.431180 | 0.365 |
R-HSA-5357801 | Programmed Cell Death | 0.431887 | 0.365 |
R-HSA-2262752 | Cellular responses to stress | 0.432760 | 0.364 |
R-HSA-774815 | Nucleosome assembly | 0.432798 | 0.364 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.432798 | 0.364 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.432798 | 0.364 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.432798 | 0.364 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.432798 | 0.364 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.432798 | 0.364 |
R-HSA-1489509 | DAG and IP3 signaling | 0.432798 | 0.364 |
R-HSA-6809371 | Formation of the cornified envelope | 0.434127 | 0.362 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.438844 | 0.358 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.438844 | 0.358 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.438844 | 0.358 |
R-HSA-9675135 | Diseases of DNA repair | 0.438844 | 0.358 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.444826 | 0.352 |
R-HSA-69481 | G2/M Checkpoints | 0.448522 | 0.348 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.450745 | 0.346 |
R-HSA-425410 | Metal ion SLC transporters | 0.450745 | 0.346 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.456601 | 0.340 |
R-HSA-74160 | Gene expression (Transcription) | 0.465857 | 0.332 |
R-HSA-418990 | Adherens junctions interactions | 0.467975 | 0.330 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.468127 | 0.330 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.469145 | 0.329 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.473799 | 0.324 |
R-HSA-8953897 | Cellular responses to stimuli | 0.477770 | 0.321 |
R-HSA-8956320 | Nucleotide biosynthesis | 0.479410 | 0.319 |
R-HSA-163685 | Integration of energy metabolism | 0.487020 | 0.312 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.490455 | 0.309 |
R-HSA-418597 | G alpha (z) signalling events | 0.490455 | 0.309 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.495037 | 0.305 |
R-HSA-177929 | Signaling by EGFR | 0.495890 | 0.305 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.495890 | 0.305 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.497229 | 0.303 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.499738 | 0.301 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.501268 | 0.300 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.501268 | 0.300 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.510639 | 0.292 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.511852 | 0.291 |
R-HSA-191859 | snRNP Assembly | 0.511852 | 0.291 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.511852 | 0.291 |
R-HSA-977443 | GABA receptor activation | 0.517060 | 0.286 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.517060 | 0.286 |
R-HSA-379724 | tRNA Aminoacylation | 0.517060 | 0.286 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.522212 | 0.282 |
R-HSA-211976 | Endogenous sterols | 0.522212 | 0.282 |
R-HSA-445717 | Aquaporin-mediated transport | 0.522212 | 0.282 |
R-HSA-8956321 | Nucleotide salvage | 0.522212 | 0.282 |
R-HSA-112043 | PLC beta mediated events | 0.522212 | 0.282 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.527311 | 0.278 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.527311 | 0.278 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.527311 | 0.278 |
R-HSA-186797 | Signaling by PDGF | 0.527311 | 0.278 |
R-HSA-373755 | Semaphorin interactions | 0.532355 | 0.274 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.536752 | 0.270 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.537345 | 0.270 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.539949 | 0.268 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.542034 | 0.266 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.542283 | 0.266 |
R-HSA-1234174 | Cellular response to hypoxia | 0.542283 | 0.266 |
R-HSA-73887 | Death Receptor Signaling | 0.549447 | 0.260 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.549447 | 0.260 |
R-HSA-112040 | G-protein mediated events | 0.552001 | 0.258 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.552001 | 0.258 |
R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.552001 | 0.258 |
R-HSA-421270 | Cell-cell junction organization | 0.554550 | 0.256 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.556783 | 0.254 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.557158 | 0.254 |
R-HSA-5688426 | Deubiquitination | 0.564473 | 0.248 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.566195 | 0.247 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.566933 | 0.246 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.570827 | 0.243 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.570827 | 0.243 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.571827 | 0.243 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.575409 | 0.240 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.579943 | 0.237 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.579943 | 0.237 |
R-HSA-9679506 | SARS-CoV Infections | 0.581766 | 0.235 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.584428 | 0.233 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.593256 | 0.227 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.595450 | 0.225 |
R-HSA-9694635 | Translation of Structural Proteins | 0.597601 | 0.224 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.601898 | 0.220 |
R-HSA-191273 | Cholesterol biosynthesis | 0.601898 | 0.220 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.609231 | 0.215 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.609231 | 0.215 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.609737 | 0.215 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.610358 | 0.214 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.614520 | 0.211 |
R-HSA-977225 | Amyloid fiber formation | 0.614520 | 0.211 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.614869 | 0.211 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.618639 | 0.209 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.618639 | 0.209 |
R-HSA-446728 | Cell junction organization | 0.618860 | 0.208 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.622713 | 0.206 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.626744 | 0.203 |
R-HSA-913531 | Interferon Signaling | 0.628570 | 0.202 |
R-HSA-2559583 | Cellular Senescence | 0.628691 | 0.202 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.634679 | 0.197 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.634679 | 0.197 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.634679 | 0.197 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.638583 | 0.195 |
R-HSA-438064 | Post NMDA receptor activation events | 0.642446 | 0.192 |
R-HSA-9645723 | Diseases of programmed cell death | 0.646267 | 0.190 |
R-HSA-202424 | Downstream TCR signaling | 0.653789 | 0.185 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.656018 | 0.183 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.657490 | 0.182 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.664774 | 0.177 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.664774 | 0.177 |
R-HSA-9609690 | HCMV Early Events | 0.670342 | 0.174 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.671905 | 0.173 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.675413 | 0.170 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.682319 | 0.166 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.682319 | 0.166 |
R-HSA-422356 | Regulation of insulin secretion | 0.689078 | 0.162 |
R-HSA-449147 | Signaling by Interleukins | 0.691465 | 0.160 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.692404 | 0.160 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.695694 | 0.158 |
R-HSA-70171 | Glycolysis | 0.695694 | 0.158 |
R-HSA-5610787 | Hedgehog 'off' state | 0.695694 | 0.158 |
R-HSA-6805567 | Keratinization | 0.696742 | 0.157 |
R-HSA-1500931 | Cell-Cell communication | 0.698262 | 0.156 |
R-HSA-9020702 | Interleukin-1 signaling | 0.698950 | 0.156 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.702171 | 0.154 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.702171 | 0.154 |
R-HSA-111885 | Opioid Signalling | 0.708510 | 0.150 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.708510 | 0.150 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.710396 | 0.148 |
R-HSA-9833110 | RSV-host interactions | 0.711629 | 0.148 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.714715 | 0.146 |
R-HSA-69239 | Synthesis of DNA | 0.720789 | 0.142 |
R-HSA-211000 | Gene Silencing by RNA | 0.720789 | 0.142 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.726734 | 0.139 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.726734 | 0.139 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.729659 | 0.137 |
R-HSA-202403 | TCR signaling | 0.729659 | 0.137 |
R-HSA-8951664 | Neddylation | 0.729915 | 0.137 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.735417 | 0.133 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.735417 | 0.133 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.738975 | 0.131 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.741052 | 0.130 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.741052 | 0.130 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.748314 | 0.126 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.749283 | 0.125 |
R-HSA-373760 | L1CAM interactions | 0.751968 | 0.124 |
R-HSA-70326 | Glucose metabolism | 0.754624 | 0.122 |
R-HSA-5693538 | Homology Directed Repair | 0.757253 | 0.121 |
R-HSA-15869 | Metabolism of nucleotides | 0.759977 | 0.119 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.764971 | 0.116 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.764971 | 0.116 |
R-HSA-112316 | Neuronal System | 0.769289 | 0.114 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.769980 | 0.114 |
R-HSA-162909 | Host Interactions of HIV factors | 0.772445 | 0.112 |
R-HSA-9675108 | Nervous system development | 0.774947 | 0.111 |
R-HSA-69206 | G1/S Transition | 0.777296 | 0.109 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.779683 | 0.108 |
R-HSA-9609646 | HCMV Infection | 0.785395 | 0.105 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.788978 | 0.103 |
R-HSA-9734767 | Developmental Cell Lineages | 0.806860 | 0.093 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.808492 | 0.092 |
R-HSA-5358351 | Signaling by Hedgehog | 0.810546 | 0.091 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.814590 | 0.089 |
R-HSA-9664407 | Parasite infection | 0.814590 | 0.089 |
R-HSA-9664417 | Leishmania phagocytosis | 0.814590 | 0.089 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.816579 | 0.088 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.820494 | 0.086 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.824326 | 0.084 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.830657 | 0.081 |
R-HSA-69242 | S Phase | 0.831747 | 0.080 |
R-HSA-9658195 | Leishmania infection | 0.833439 | 0.079 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.833439 | 0.079 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.834815 | 0.078 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.835340 | 0.078 |
R-HSA-446652 | Interleukin-1 family signaling | 0.838857 | 0.076 |
R-HSA-69306 | DNA Replication | 0.840587 | 0.075 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.840587 | 0.075 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.843993 | 0.074 |
R-HSA-9610379 | HCMV Late Events | 0.847326 | 0.072 |
R-HSA-162587 | HIV Life Cycle | 0.847326 | 0.072 |
R-HSA-877300 | Interferon gamma signaling | 0.850588 | 0.070 |
R-HSA-1483257 | Phospholipid metabolism | 0.851793 | 0.070 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.852193 | 0.069 |
R-HSA-422475 | Axon guidance | 0.857535 | 0.067 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.858443 | 0.066 |
R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.862958 | 0.064 |
R-HSA-5619102 | SLC transporter disorders | 0.862958 | 0.064 |
R-HSA-72306 | tRNA processing | 0.868756 | 0.061 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.870167 | 0.060 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.872943 | 0.059 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.872943 | 0.059 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.874309 | 0.058 |
R-HSA-168255 | Influenza Infection | 0.880924 | 0.055 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.883107 | 0.054 |
R-HSA-8957322 | Metabolism of steroids | 0.884104 | 0.053 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.885940 | 0.053 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.885966 | 0.053 |
R-HSA-3781865 | Diseases of glycosylation | 0.887193 | 0.052 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.897661 | 0.047 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.898762 | 0.046 |
R-HSA-428157 | Sphingolipid metabolism | 0.906151 | 0.043 |
R-HSA-376176 | Signaling by ROBO receptors | 0.908162 | 0.042 |
R-HSA-72172 | mRNA Splicing | 0.910130 | 0.041 |
R-HSA-73894 | DNA Repair | 0.915176 | 0.038 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.918103 | 0.037 |
R-HSA-68882 | Mitotic Anaphase | 0.921088 | 0.036 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.921939 | 0.035 |
R-HSA-9824446 | Viral Infection Pathways | 0.928734 | 0.032 |
R-HSA-199991 | Membrane Trafficking | 0.929665 | 0.032 |
R-HSA-162906 | HIV Infection | 0.929961 | 0.032 |
R-HSA-388396 | GPCR downstream signalling | 0.930213 | 0.031 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.931370 | 0.031 |
R-HSA-109582 | Hemostasis | 0.934722 | 0.029 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.937164 | 0.028 |
R-HSA-1280218 | Adaptive Immune System | 0.942421 | 0.026 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.943629 | 0.025 |
R-HSA-597592 | Post-translational protein modification | 0.952825 | 0.021 |
R-HSA-416476 | G alpha (q) signalling events | 0.953138 | 0.021 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.959757 | 0.018 |
R-HSA-372790 | Signaling by GPCR | 0.960505 | 0.018 |
R-HSA-195721 | Signaling by WNT | 0.967633 | 0.014 |
R-HSA-1474244 | Extracellular matrix organization | 0.977417 | 0.010 |
R-HSA-5653656 | Vesicle-mediated transport | 0.978938 | 0.009 |
R-HSA-8953854 | Metabolism of RNA | 0.983002 | 0.007 |
R-HSA-556833 | Metabolism of lipids | 0.983542 | 0.007 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.988286 | 0.005 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.989152 | 0.005 |
R-HSA-5663205 | Infectious disease | 0.990203 | 0.004 |
R-HSA-418594 | G alpha (i) signalling events | 0.990279 | 0.004 |
R-HSA-168256 | Immune System | 0.991740 | 0.004 |
R-HSA-5668914 | Diseases of metabolism | 0.992195 | 0.003 |
R-HSA-72766 | Translation | 0.992365 | 0.003 |
R-HSA-1643685 | Disease | 0.994141 | 0.003 |
R-HSA-6798695 | Neutrophil degranulation | 0.994389 | 0.002 |
R-HSA-392499 | Metabolism of proteins | 0.995322 | 0.002 |
R-HSA-168249 | Innate Immune System | 0.996878 | 0.001 |
R-HSA-211859 | Biological oxidations | 0.997291 | 0.001 |
R-HSA-382551 | Transport of small molecules | 0.998774 | 0.001 |
R-HSA-381753 | Olfactory Signaling Pathway | 0.999941 | 0.000 |
R-HSA-1430728 | Metabolism | 0.999996 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CDK19 |
0.863 | 0.881 | 1 | 0.827 |
CDK18 |
0.860 | 0.864 | 1 | 0.842 |
HIPK2 |
0.857 | 0.792 | 1 | 0.820 |
CDK17 |
0.856 | 0.860 | 1 | 0.870 |
CDK8 |
0.855 | 0.877 | 1 | 0.792 |
P38G |
0.853 | 0.875 | 1 | 0.874 |
CDK7 |
0.850 | 0.847 | 1 | 0.796 |
CDK3 |
0.849 | 0.753 | 1 | 0.862 |
ERK1 |
0.848 | 0.878 | 1 | 0.819 |
JNK2 |
0.848 | 0.870 | 1 | 0.835 |
P38D |
0.847 | 0.861 | 1 | 0.881 |
P38B |
0.846 | 0.895 | 1 | 0.802 |
CDK1 |
0.845 | 0.824 | 1 | 0.819 |
CDK16 |
0.845 | 0.824 | 1 | 0.859 |
CDK13 |
0.843 | 0.820 | 1 | 0.818 |
CDK12 |
0.843 | 0.821 | 1 | 0.838 |
CDK5 |
0.842 | 0.813 | 1 | 0.770 |
KIS |
0.841 | 0.708 | 1 | 0.768 |
DYRK2 |
0.839 | 0.763 | 1 | 0.733 |
P38A |
0.836 | 0.876 | 1 | 0.736 |
JNK3 |
0.834 | 0.845 | 1 | 0.809 |
DYRK4 |
0.834 | 0.754 | 1 | 0.828 |
CDK9 |
0.833 | 0.791 | 1 | 0.810 |
DYRK1B |
0.830 | 0.727 | 1 | 0.792 |
HIPK4 |
0.830 | 0.569 | 1 | 0.526 |
CDK10 |
0.830 | 0.751 | 1 | 0.821 |
HIPK1 |
0.829 | 0.697 | 1 | 0.715 |
CDK14 |
0.828 | 0.793 | 1 | 0.804 |
CDK4 |
0.825 | 0.809 | 1 | 0.847 |
DYRK1A |
0.825 | 0.663 | 1 | 0.701 |
ERK2 |
0.824 | 0.826 | 1 | 0.773 |
MAK |
0.823 | 0.663 | -2 | 0.921 |
CLK3 |
0.823 | 0.511 | 1 | 0.501 |
CDK6 |
0.822 | 0.782 | 1 | 0.823 |
HIPK3 |
0.821 | 0.685 | 1 | 0.686 |
JNK1 |
0.814 | 0.756 | 1 | 0.836 |
NLK |
0.813 | 0.715 | 1 | 0.528 |
SRPK1 |
0.809 | 0.342 | -3 | 0.714 |
CDK2 |
0.809 | 0.612 | 1 | 0.694 |
ERK5 |
0.808 | 0.449 | 1 | 0.439 |
ICK |
0.806 | 0.514 | -3 | 0.802 |
DYRK3 |
0.806 | 0.536 | 1 | 0.678 |
MOK |
0.803 | 0.572 | 1 | 0.604 |
CDKL5 |
0.803 | 0.301 | -3 | 0.752 |
CLK2 |
0.798 | 0.382 | -3 | 0.711 |
CLK1 |
0.795 | 0.378 | -3 | 0.713 |
MTOR |
0.794 | 0.259 | 1 | 0.319 |
SRPK2 |
0.793 | 0.261 | -3 | 0.626 |
CDKL1 |
0.792 | 0.238 | -3 | 0.755 |
PRP4 |
0.790 | 0.477 | -3 | 0.770 |
CLK4 |
0.788 | 0.332 | -3 | 0.729 |
COT |
0.787 | -0.049 | 2 | 0.846 |
TBK1 |
0.781 | -0.073 | 1 | 0.118 |
SRPK3 |
0.779 | 0.229 | -3 | 0.668 |
PRKD1 |
0.779 | 0.008 | -3 | 0.805 |
NDR2 |
0.779 | 0.006 | -3 | 0.817 |
CDC7 |
0.778 | -0.053 | 1 | 0.143 |
MOS |
0.778 | 0.020 | 1 | 0.188 |
ERK7 |
0.777 | 0.291 | 2 | 0.545 |
CHAK2 |
0.776 | 0.028 | -1 | 0.824 |
PRPK |
0.776 | -0.032 | -1 | 0.848 |
PIM3 |
0.775 | -0.021 | -3 | 0.801 |
IKKE |
0.774 | -0.121 | 1 | 0.117 |
MPSK1 |
0.773 | 0.216 | 1 | 0.216 |
ATR |
0.773 | -0.010 | 1 | 0.195 |
PRKD2 |
0.773 | -0.002 | -3 | 0.754 |
WNK1 |
0.772 | -0.036 | -2 | 0.763 |
NUAK2 |
0.770 | 0.004 | -3 | 0.810 |
PDHK4 |
0.769 | -0.120 | 1 | 0.202 |
NEK6 |
0.768 | -0.073 | -2 | 0.663 |
MST4 |
0.768 | -0.043 | 2 | 0.809 |
RAF1 |
0.768 | -0.159 | 1 | 0.136 |
ULK2 |
0.768 | -0.176 | 2 | 0.782 |
MLK2 |
0.768 | -0.000 | 2 | 0.808 |
IKKB |
0.766 | -0.180 | -2 | 0.606 |
MARK4 |
0.766 | -0.044 | 4 | 0.834 |
NDR1 |
0.766 | -0.058 | -3 | 0.799 |
PKN3 |
0.766 | -0.058 | -3 | 0.782 |
PDHK1 |
0.766 | -0.143 | 1 | 0.180 |
CAMK1B |
0.766 | -0.064 | -3 | 0.820 |
SKMLCK |
0.765 | -0.046 | -2 | 0.721 |
PKCD |
0.765 | -0.023 | 2 | 0.760 |
AURC |
0.765 | -0.006 | -2 | 0.513 |
GCN2 |
0.765 | -0.214 | 2 | 0.775 |
AMPKA1 |
0.765 | -0.048 | -3 | 0.825 |
IRE1 |
0.765 | -0.038 | 1 | 0.146 |
TSSK1 |
0.764 | -0.026 | -3 | 0.848 |
NIK |
0.764 | -0.065 | -3 | 0.839 |
BMPR2 |
0.763 | -0.195 | -2 | 0.704 |
MAPKAPK3 |
0.763 | -0.062 | -3 | 0.745 |
PIM1 |
0.763 | -0.001 | -3 | 0.747 |
AMPKA2 |
0.762 | -0.031 | -3 | 0.792 |
IKKA |
0.762 | -0.087 | -2 | 0.614 |
MNK2 |
0.762 | -0.025 | -2 | 0.642 |
RIPK3 |
0.761 | -0.106 | 3 | 0.753 |
GRK1 |
0.761 | -0.033 | -2 | 0.662 |
PKCZ |
0.760 | -0.010 | 2 | 0.773 |
PKN2 |
0.760 | -0.081 | -3 | 0.801 |
TSSK2 |
0.760 | -0.068 | -5 | 0.846 |
DSTYK |
0.760 | -0.189 | 2 | 0.841 |
CAMLCK |
0.760 | -0.044 | -2 | 0.689 |
P90RSK |
0.760 | -0.038 | -3 | 0.736 |
MLK3 |
0.760 | -0.004 | 2 | 0.706 |
ULK1 |
0.759 | -0.166 | -3 | 0.772 |
MLK1 |
0.759 | -0.117 | 2 | 0.780 |
LATS2 |
0.759 | -0.059 | -5 | 0.742 |
BCKDK |
0.759 | -0.136 | -1 | 0.785 |
DAPK2 |
0.758 | -0.060 | -3 | 0.827 |
DNAPK |
0.758 | -0.024 | 1 | 0.192 |
MAPKAPK2 |
0.758 | -0.045 | -3 | 0.700 |
PKCB |
0.757 | -0.024 | 2 | 0.710 |
NEK7 |
0.757 | -0.199 | -3 | 0.803 |
RSK2 |
0.757 | -0.049 | -3 | 0.738 |
CAMK2G |
0.757 | -0.127 | 2 | 0.760 |
PRKD3 |
0.757 | -0.030 | -3 | 0.713 |
WNK3 |
0.756 | -0.173 | 1 | 0.142 |
IRE2 |
0.756 | -0.043 | 2 | 0.751 |
PKACG |
0.756 | -0.066 | -2 | 0.586 |
NIM1 |
0.756 | -0.090 | 3 | 0.783 |
PKCG |
0.756 | -0.029 | 2 | 0.702 |
PKCA |
0.756 | -0.015 | 2 | 0.700 |
QSK |
0.756 | -0.032 | 4 | 0.810 |
NUAK1 |
0.756 | -0.048 | -3 | 0.748 |
PAK1 |
0.755 | -0.049 | -2 | 0.661 |
TGFBR2 |
0.755 | -0.147 | -2 | 0.586 |
NEK9 |
0.755 | -0.167 | 2 | 0.817 |
MNK1 |
0.755 | -0.022 | -2 | 0.646 |
P70S6KB |
0.755 | -0.049 | -3 | 0.752 |
PHKG1 |
0.754 | -0.070 | -3 | 0.794 |
RSK3 |
0.754 | -0.062 | -3 | 0.721 |
MASTL |
0.754 | -0.164 | -2 | 0.687 |
LATS1 |
0.754 | 0.003 | -3 | 0.826 |
HUNK |
0.754 | -0.167 | 2 | 0.769 |
PAK3 |
0.754 | -0.076 | -2 | 0.648 |
CHAK1 |
0.754 | -0.077 | 2 | 0.791 |
MELK |
0.754 | -0.082 | -3 | 0.772 |
CAMK2D |
0.754 | -0.120 | -3 | 0.805 |
GRK5 |
0.753 | -0.167 | -3 | 0.819 |
GRK7 |
0.753 | -0.001 | 1 | 0.158 |
GSK3A |
0.753 | 0.200 | 4 | 0.432 |
ATM |
0.752 | -0.079 | 1 | 0.162 |
VRK2 |
0.752 | 0.079 | 1 | 0.238 |
RIPK1 |
0.751 | -0.178 | 1 | 0.129 |
PAK6 |
0.751 | -0.038 | -2 | 0.568 |
QIK |
0.750 | -0.103 | -3 | 0.799 |
PKACB |
0.750 | -0.021 | -2 | 0.513 |
SGK3 |
0.750 | -0.032 | -3 | 0.730 |
NEK2 |
0.750 | -0.123 | 2 | 0.807 |
PKG2 |
0.749 | -0.043 | -2 | 0.524 |
DLK |
0.749 | -0.178 | 1 | 0.141 |
SIK |
0.749 | -0.058 | -3 | 0.722 |
PKR |
0.748 | -0.086 | 1 | 0.163 |
BRSK2 |
0.748 | -0.079 | -3 | 0.782 |
PINK1 |
0.748 | 0.124 | 1 | 0.362 |
AURB |
0.748 | -0.047 | -2 | 0.504 |
SMG1 |
0.747 | -0.076 | 1 | 0.184 |
YSK4 |
0.747 | -0.151 | 1 | 0.120 |
MARK3 |
0.747 | -0.044 | 4 | 0.770 |
BMPR1B |
0.746 | -0.086 | 1 | 0.106 |
PRKX |
0.746 | -0.003 | -3 | 0.662 |
BRSK1 |
0.746 | -0.068 | -3 | 0.752 |
AKT2 |
0.746 | -0.014 | -3 | 0.654 |
CAMK4 |
0.746 | -0.147 | -3 | 0.784 |
RSK4 |
0.746 | -0.033 | -3 | 0.710 |
MSK2 |
0.746 | -0.080 | -3 | 0.699 |
FAM20C |
0.745 | -0.019 | 2 | 0.578 |
SSTK |
0.745 | -0.037 | 4 | 0.814 |
PKCH |
0.745 | -0.074 | 2 | 0.699 |
ANKRD3 |
0.744 | -0.215 | 1 | 0.152 |
IRAK4 |
0.744 | -0.087 | 1 | 0.127 |
TTBK2 |
0.744 | -0.189 | 2 | 0.683 |
MLK4 |
0.744 | -0.077 | 2 | 0.699 |
ALK4 |
0.743 | -0.114 | -2 | 0.630 |
WNK4 |
0.743 | -0.081 | -2 | 0.761 |
PAK2 |
0.743 | -0.093 | -2 | 0.641 |
TAO3 |
0.743 | -0.009 | 1 | 0.168 |
PIM2 |
0.743 | -0.015 | -3 | 0.707 |
CAMK2A |
0.742 | -0.059 | 2 | 0.734 |
TGFBR1 |
0.742 | -0.106 | -2 | 0.605 |
MARK2 |
0.742 | -0.067 | 4 | 0.734 |
DCAMKL1 |
0.741 | -0.062 | -3 | 0.761 |
CAMK2B |
0.741 | -0.097 | 2 | 0.729 |
MEK1 |
0.741 | -0.161 | 2 | 0.825 |
GRK6 |
0.740 | -0.185 | 1 | 0.126 |
CHK1 |
0.740 | -0.083 | -3 | 0.787 |
PLK4 |
0.740 | -0.132 | 2 | 0.624 |
PKCT |
0.740 | -0.071 | 2 | 0.714 |
MST3 |
0.740 | -0.056 | 2 | 0.799 |
AKT1 |
0.739 | -0.031 | -3 | 0.677 |
TLK2 |
0.738 | -0.147 | 1 | 0.138 |
CK1E |
0.738 | -0.008 | -3 | 0.558 |
NEK5 |
0.738 | -0.124 | 1 | 0.142 |
MEK5 |
0.738 | -0.135 | 2 | 0.811 |
MEKK1 |
0.737 | -0.143 | 1 | 0.148 |
MSK1 |
0.737 | -0.073 | -3 | 0.701 |
GRK4 |
0.737 | -0.204 | -2 | 0.651 |
PKCI |
0.737 | -0.048 | 2 | 0.737 |
PHKG2 |
0.737 | -0.090 | -3 | 0.766 |
MARK1 |
0.736 | -0.092 | 4 | 0.799 |
ZAK |
0.736 | -0.153 | 1 | 0.124 |
MEKK2 |
0.736 | -0.116 | 2 | 0.795 |
MYLK4 |
0.736 | -0.088 | -2 | 0.607 |
PLK1 |
0.736 | -0.194 | -2 | 0.594 |
SNRK |
0.736 | -0.171 | 2 | 0.679 |
PAK5 |
0.735 | -0.061 | -2 | 0.527 |
LKB1 |
0.735 | -0.022 | -3 | 0.806 |
BUB1 |
0.735 | 0.034 | -5 | 0.770 |
HASPIN |
0.735 | 0.070 | -1 | 0.733 |
MAP3K15 |
0.734 | -0.025 | 1 | 0.139 |
CAMK1G |
0.734 | -0.095 | -3 | 0.712 |
PKACA |
0.733 | -0.042 | -2 | 0.470 |
HRI |
0.732 | -0.184 | -2 | 0.659 |
ACVR2A |
0.732 | -0.157 | -2 | 0.578 |
GCK |
0.732 | -0.039 | 1 | 0.152 |
PERK |
0.732 | -0.192 | -2 | 0.646 |
ACVR2B |
0.732 | -0.153 | -2 | 0.591 |
TAO2 |
0.732 | -0.044 | 2 | 0.818 |
AURA |
0.732 | -0.076 | -2 | 0.474 |
BRAF |
0.731 | -0.150 | -4 | 0.795 |
PAK4 |
0.731 | -0.054 | -2 | 0.532 |
HGK |
0.731 | -0.040 | 3 | 0.911 |
KHS1 |
0.731 | 0.002 | 1 | 0.148 |
NEK11 |
0.731 | -0.117 | 1 | 0.163 |
MAPKAPK5 |
0.731 | -0.134 | -3 | 0.655 |
DCAMKL2 |
0.731 | -0.081 | -3 | 0.782 |
GSK3B |
0.731 | 0.037 | 4 | 0.424 |
GRK2 |
0.731 | -0.114 | -2 | 0.560 |
PBK |
0.730 | -0.012 | 1 | 0.183 |
DRAK1 |
0.730 | -0.170 | 1 | 0.104 |
ALK2 |
0.730 | -0.140 | -2 | 0.605 |
PDK1 |
0.730 | -0.068 | 1 | 0.178 |
TNIK |
0.730 | -0.025 | 3 | 0.907 |
PKN1 |
0.729 | -0.060 | -3 | 0.685 |
MEKK3 |
0.729 | -0.198 | 1 | 0.138 |
SBK |
0.729 | 0.073 | -3 | 0.538 |
PKCE |
0.729 | -0.031 | 2 | 0.688 |
LRRK2 |
0.728 | 0.007 | 2 | 0.826 |
KHS2 |
0.728 | 0.010 | 1 | 0.161 |
MEKK6 |
0.728 | -0.074 | 1 | 0.145 |
SMMLCK |
0.728 | -0.083 | -3 | 0.771 |
CAMKK2 |
0.728 | -0.123 | -2 | 0.635 |
NEK4 |
0.728 | -0.134 | 1 | 0.131 |
AKT3 |
0.728 | -0.024 | -3 | 0.597 |
CK1D |
0.727 | -0.008 | -3 | 0.514 |
TLK1 |
0.727 | -0.179 | -2 | 0.624 |
MINK |
0.727 | -0.091 | 1 | 0.129 |
HPK1 |
0.726 | -0.065 | 1 | 0.152 |
PASK |
0.726 | -0.062 | -3 | 0.824 |
EEF2K |
0.726 | -0.024 | 3 | 0.886 |
LOK |
0.726 | -0.072 | -2 | 0.646 |
PLK3 |
0.726 | -0.176 | 2 | 0.725 |
P70S6K |
0.725 | -0.085 | -3 | 0.655 |
GAK |
0.725 | -0.073 | 1 | 0.196 |
CAMKK1 |
0.725 | -0.186 | -2 | 0.619 |
SGK1 |
0.725 | -0.008 | -3 | 0.571 |
BMPR1A |
0.724 | -0.119 | 1 | 0.097 |
SLK |
0.722 | -0.061 | -2 | 0.615 |
CK1G1 |
0.722 | -0.070 | -3 | 0.539 |
CAMK1D |
0.722 | -0.079 | -3 | 0.653 |
MST2 |
0.722 | -0.136 | 1 | 0.133 |
NEK8 |
0.721 | -0.191 | 2 | 0.797 |
NEK1 |
0.720 | -0.130 | 1 | 0.123 |
ROCK2 |
0.720 | -0.037 | -3 | 0.756 |
VRK1 |
0.720 | -0.107 | 2 | 0.837 |
DAPK3 |
0.718 | -0.081 | -3 | 0.764 |
CK1A2 |
0.718 | -0.038 | -3 | 0.510 |
YSK1 |
0.717 | -0.101 | 2 | 0.789 |
MRCKB |
0.717 | -0.047 | -3 | 0.699 |
TTBK1 |
0.716 | -0.185 | 2 | 0.598 |
MRCKA |
0.716 | -0.058 | -3 | 0.713 |
MST1 |
0.715 | -0.137 | 1 | 0.126 |
CK2A2 |
0.715 | -0.082 | 1 | 0.093 |
IRAK1 |
0.715 | -0.239 | -1 | 0.740 |
CHK2 |
0.715 | -0.063 | -3 | 0.604 |
CAMK1A |
0.715 | -0.065 | -3 | 0.621 |
BIKE |
0.714 | -0.024 | 1 | 0.191 |
PDHK3_TYR |
0.714 | 0.211 | 4 | 0.898 |
GRK3 |
0.713 | -0.124 | -2 | 0.515 |
AAK1 |
0.712 | 0.010 | 1 | 0.202 |
NEK3 |
0.712 | -0.130 | 1 | 0.149 |
TAO1 |
0.711 | -0.058 | 1 | 0.141 |
TAK1 |
0.711 | -0.207 | 1 | 0.129 |
DMPK1 |
0.711 | -0.016 | -3 | 0.730 |
LIMK2_TYR |
0.710 | 0.163 | -3 | 0.862 |
PKG1 |
0.709 | -0.076 | -2 | 0.441 |
DAPK1 |
0.709 | -0.095 | -3 | 0.744 |
STK33 |
0.709 | -0.141 | 2 | 0.584 |
MYO3B |
0.708 | -0.058 | 2 | 0.809 |
MEK2 |
0.707 | -0.198 | 2 | 0.812 |
ASK1 |
0.707 | -0.087 | 1 | 0.137 |
CK2A1 |
0.707 | -0.089 | 1 | 0.084 |
OSR1 |
0.707 | -0.076 | 2 | 0.797 |
TESK1_TYR |
0.706 | 0.077 | 3 | 0.894 |
ROCK1 |
0.706 | -0.054 | -3 | 0.713 |
RIPK2 |
0.705 | -0.235 | 1 | 0.111 |
PKMYT1_TYR |
0.704 | 0.135 | 3 | 0.856 |
CRIK |
0.704 | -0.035 | -3 | 0.679 |
PDHK4_TYR |
0.704 | 0.081 | 2 | 0.846 |
MYO3A |
0.703 | -0.082 | 1 | 0.153 |
MAP2K4_TYR |
0.699 | 0.006 | -1 | 0.865 |
MAP2K7_TYR |
0.697 | -0.060 | 2 | 0.827 |
TTK |
0.696 | -0.131 | -2 | 0.618 |
MAP2K6_TYR |
0.696 | 0.003 | -1 | 0.867 |
LIMK1_TYR |
0.696 | 0.029 | 2 | 0.836 |
ALPHAK3 |
0.695 | -0.083 | -1 | 0.766 |
PLK2 |
0.695 | -0.131 | -3 | 0.707 |
NEK10_TYR |
0.694 | -0.050 | 1 | 0.145 |
PDHK1_TYR |
0.694 | -0.013 | -1 | 0.860 |
TNNI3K_TYR |
0.693 | 0.012 | 1 | 0.176 |
JAK2 |
0.693 | -0.071 | 1 | 0.166 |
PINK1_TYR |
0.692 | -0.137 | 1 | 0.190 |
BMPR2_TYR |
0.692 | -0.027 | -1 | 0.860 |
RET |
0.692 | -0.108 | 1 | 0.159 |
TYK2 |
0.691 | -0.151 | 1 | 0.148 |
JAK1 |
0.689 | -0.043 | 1 | 0.138 |
CSF1R |
0.689 | -0.046 | 3 | 0.815 |
MST1R |
0.689 | -0.079 | 3 | 0.826 |
ROS1 |
0.688 | -0.083 | 3 | 0.803 |
JAK3 |
0.688 | -0.084 | 1 | 0.147 |
STLK3 |
0.687 | -0.171 | 1 | 0.112 |
TNK1 |
0.687 | -0.019 | 3 | 0.799 |
YANK3 |
0.683 | -0.077 | 2 | 0.359 |
TYRO3 |
0.683 | -0.140 | 3 | 0.831 |
EPHB4 |
0.682 | -0.095 | -1 | 0.798 |
DDR1 |
0.682 | -0.106 | 4 | 0.819 |
CK1A |
0.682 | -0.059 | -3 | 0.425 |
EPHA6 |
0.681 | -0.104 | -1 | 0.827 |
ABL2 |
0.680 | -0.102 | -1 | 0.757 |
TXK |
0.679 | -0.075 | 1 | 0.101 |
TNK2 |
0.678 | -0.074 | 3 | 0.755 |
FGFR1 |
0.678 | -0.047 | 3 | 0.772 |
INSRR |
0.676 | -0.124 | 3 | 0.757 |
DDR2 |
0.676 | 0.002 | 3 | 0.736 |
FGFR2 |
0.676 | -0.066 | 3 | 0.780 |
YES1 |
0.676 | -0.110 | -1 | 0.779 |
ABL1 |
0.675 | -0.116 | -1 | 0.747 |
KDR |
0.675 | -0.094 | 3 | 0.766 |
KIT |
0.674 | -0.118 | 3 | 0.809 |
PDGFRB |
0.673 | -0.181 | 3 | 0.830 |
LCK |
0.673 | -0.099 | -1 | 0.774 |
FGR |
0.672 | -0.194 | 1 | 0.122 |
TEK |
0.672 | -0.053 | 3 | 0.743 |
PDGFRA |
0.671 | -0.167 | 3 | 0.829 |
WEE1_TYR |
0.670 | -0.082 | -1 | 0.730 |
HCK |
0.670 | -0.159 | -1 | 0.770 |
ITK |
0.670 | -0.135 | -1 | 0.750 |
BLK |
0.669 | -0.094 | -1 | 0.770 |
MET |
0.669 | -0.100 | 3 | 0.793 |
FLT3 |
0.668 | -0.182 | 3 | 0.824 |
EPHB1 |
0.667 | -0.169 | 1 | 0.104 |
EPHA4 |
0.667 | -0.110 | 2 | 0.711 |
FER |
0.666 | -0.219 | 1 | 0.129 |
EPHB3 |
0.665 | -0.171 | -1 | 0.774 |
AXL |
0.665 | -0.178 | 3 | 0.782 |
EPHB2 |
0.664 | -0.156 | -1 | 0.769 |
BMX |
0.664 | -0.115 | -1 | 0.671 |
ALK |
0.664 | -0.149 | 3 | 0.737 |
SRMS |
0.664 | -0.200 | 1 | 0.100 |
FGFR3 |
0.663 | -0.092 | 3 | 0.751 |
INSR |
0.663 | -0.134 | 3 | 0.738 |
MERTK |
0.662 | -0.171 | 3 | 0.773 |
FYN |
0.661 | -0.103 | -1 | 0.757 |
FLT1 |
0.658 | -0.156 | -1 | 0.810 |
BTK |
0.658 | -0.219 | -1 | 0.702 |
TEC |
0.657 | -0.173 | -1 | 0.678 |
LTK |
0.657 | -0.180 | 3 | 0.748 |
ERBB2 |
0.657 | -0.186 | 1 | 0.125 |
FLT4 |
0.657 | -0.167 | 3 | 0.748 |
FRK |
0.657 | -0.161 | -1 | 0.769 |
EPHA7 |
0.656 | -0.142 | 2 | 0.724 |
EGFR |
0.656 | -0.119 | 1 | 0.094 |
EPHA1 |
0.656 | -0.169 | 3 | 0.775 |
NTRK1 |
0.655 | -0.227 | -1 | 0.787 |
NTRK2 |
0.655 | -0.219 | 3 | 0.762 |
PTK6 |
0.655 | -0.215 | -1 | 0.692 |
NTRK3 |
0.654 | -0.160 | -1 | 0.741 |
LYN |
0.653 | -0.158 | 3 | 0.730 |
CK1G3 |
0.653 | -0.081 | -3 | 0.378 |
EPHA3 |
0.652 | -0.169 | 2 | 0.690 |
MUSK |
0.651 | -0.142 | 1 | 0.086 |
MATK |
0.650 | -0.124 | -1 | 0.684 |
SRC |
0.650 | -0.143 | -1 | 0.744 |
PTK2B |
0.649 | -0.142 | -1 | 0.722 |
CSK |
0.649 | -0.134 | 2 | 0.724 |
YANK2 |
0.648 | -0.097 | 2 | 0.374 |
FGFR4 |
0.647 | -0.125 | -1 | 0.734 |
EPHA8 |
0.645 | -0.148 | -1 | 0.753 |
EPHA5 |
0.645 | -0.174 | 2 | 0.700 |
PTK2 |
0.644 | -0.087 | -1 | 0.781 |
SYK |
0.643 | -0.118 | -1 | 0.755 |
ERBB4 |
0.642 | -0.108 | 1 | 0.095 |
IGF1R |
0.641 | -0.153 | 3 | 0.665 |
EPHA2 |
0.636 | -0.152 | -1 | 0.732 |
ZAP70 |
0.636 | -0.082 | -1 | 0.691 |
CK1G2 |
0.631 | -0.088 | -3 | 0.463 |
FES |
0.624 | -0.163 | -1 | 0.653 |