Motif 52 (n=160)

Position-wise Probabilities

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uniprot genes site source protein function
A0AV02 SLC12A8 S665 ochoa Solute carrier family 12 member 8 (Cation-chloride cotransporter 9) Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}.
A4FU49 SH3D21 S269 ochoa SH3 domain-containing protein 21 None
A6NDB9 PALM3 S72 ochoa Paralemmin-3 ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}.
A8MUU9 None S321 ochoa Putative uncharacterized protein ENSP00000383309 None
B8ZZF3 None S369 ochoa Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}.
H3BRB1 None S238 ochoa polynucleotide adenylyltransferase (EC 2.7.7.19) None
O14647 CHD2 S1789 ochoa Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.
O15265 ATXN7 S571 ochoa Ataxin-7 (Spinocerebellar ataxia type 7 protein) Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}.
O60266 ADCY3 S525 ochoa Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3) Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}.
O60336 MAPKBP1 S488 ochoa Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.
O75030 MITF S180 psp Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}.
O75376 NCOR1 S1281 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75427 LRCH4 S281 ochoa Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}.
O75444 MAF S70 psp Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. {ECO:0000250, ECO:0000269|PubMed:12149651, ECO:0000269|PubMed:14998494, ECO:0000269|PubMed:15007382, ECO:0000269|PubMed:16247450, ECO:0000269|PubMed:19143053}.
O94806 PRKD3 S543 ochoa Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
O94887 FARP2 S876 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O95155 UBE4B S238 ochoa Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}.
O95359 TACC2 S1635 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O95398 RAPGEF3 S864 ochoa Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}.
O95402 MED26 S361 ochoa Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
O95613 PCNT S2214 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
O95758 PTBP3 S56 ochoa Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}.
P10244 MYBL2 S452 ochoa|psp Myb-related protein B (B-Myb) (Myb-like protein 2) Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.
P15822 HIVEP1 S1158 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P15822 HIVEP1 S2297 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P17535 JUND S43 ochoa Transcription factor JunD (Transcription factor AP-1 subunit JunD) Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}.
P17535 JUND S90 ochoa Transcription factor JunD (Transcription factor AP-1 subunit JunD) Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}.
P18146 EGR1 S26 ochoa|psp Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}.
P19532 TFE3 S246 psp Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}.
P19634 SLC9A1 S726 ochoa|psp Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}.
P23771 GATA3 S162 ochoa|psp Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P23772, ECO:0000269|PubMed:23824597}.
P27361 MAPK3 S263 ochoa Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) (PubMed:35216969). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. {ECO:0000269|PubMed:10393181, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:34497368, ECO:0000269|PubMed:35216969, ECO:0000269|PubMed:8325880, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9480836}.
P29353 SHC1 S54 psp SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}.
P35712 SOX6 S442 ochoa Transcription factor SOX-6 Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}.
P42226 STAT6 S756 psp Signal transducer and activator of transcription 6 (IL-4 Stat) Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218}.
P43354 NR4A2 S256 ochoa Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}.
P46019 PHKA2 S735 ochoa Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
P47974 ZFP36L2 S448 ochoa mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}.
P48378 RFX2 S28 ochoa DNA-binding protein RFX2 (Regulatory factor X 2) Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:10330134}.
P48552 NRIP1 S807 ochoa Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}.
P49642 PRIM1 S310 ochoa DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed:17893144, PubMed:24043831, PubMed:25550159, PubMed:26975377, PubMed:31479243, PubMed:33060134, PubMed:9268648, PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs) (PubMed:26975377). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end (PubMed:25550159, PubMed:26975377). Binds single stranded DNA (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:33060134, ECO:0000269|PubMed:9268648, ECO:0000269|PubMed:9705292}.
P54821 PRRX1 S21 ochoa Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). {ECO:0000250|UniProtKB:P63013, ECO:0000269|PubMed:35589735}.; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. {ECO:0000250|UniProtKB:P63013}.; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. {ECO:0000250|UniProtKB:P63013}.
P54868 HMGCS2 S433 ochoa Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}.
P57682 KLF3 S224 ochoa|psp Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.
P78413 IRX4 S430 ochoa Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) Likely to be an important mediator of ventricular differentiation during cardiac development.
P78524 DENND2B S539 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
Q05932 FPGS S539 ochoa Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.
Q05D32 CTDSPL2 S134 ochoa|psp CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) Probable phosphatase. {ECO:0000250}.
Q06203 PPAT S399 ochoa Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. {ECO:0000250|UniProtKB:P35433}.
Q07157 TJP1 S968 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q08174 PCDH1 S949 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q12772 SREBF2 S469 ochoa Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}.
Q12772 SREBF2 S1046 ochoa Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}.
Q12851 MAP4K2 S298 ochoa Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}.
Q13233 MAP3K1 S1018 ochoa Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}.
Q14139 UBE4A S551 ochoa Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}.
Q15735 INPP5J S150 ochoa Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56) Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. {ECO:0000250|UniProtKB:Q9JMC1}.
Q15788 NCOA1 S325 psp Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.
Q15788 NCOA1 S1279 psp Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.
Q16236 NFE2L2 S577 psp Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}.
Q17RY0 CPEB4 S340 ochoa Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4) Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}.
Q4VCS5 AMOT S200 ochoa Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q5JPH6 EARS2 S143 ochoa Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS) Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation (PubMed:19805282). Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln) (PubMed:19805282). In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity (PubMed:19805282). {ECO:0000269|PubMed:19805282}.
Q5TCZ1 SH3PXD2A S662 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5VUB5 FAM171A1 S525 ochoa Protein FAM171A1 (Astroprincin) (APCN) Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}.
Q66K74 MAP1S S731 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q6BDS2 BLTP3A S928 ochoa Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}.
Q6IMN6 CAPRIN2 S660 ochoa Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). {ECO:0000250|UniProtKB:Q05A80, ECO:0000269|PubMed:14593112, ECO:0000269|PubMed:18762581, ECO:0000269|PubMed:27821587}.
Q6MZQ0 PRR5L S29 ochoa Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}.
Q6NUJ5 PWWP2B S60 ochoa PWWP domain-containing protein 2B Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}.
Q6S5L8 SHC4 S132 ochoa|psp SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
Q6UB99 ANKRD11 S1509 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6WBX8 RAD9B S282 ochoa Cell cycle checkpoint control protein RAD9B (DNA repair exonuclease rad9 homolog B) (hRAD9B) None
Q70E73 RAPH1 S54 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q70EL1 USP54 S1286 ochoa Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}.
Q7Z3V4 UBE3B S419 ochoa Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes (By similarity). Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC (By similarity). {ECO:0000250|UniProtKB:Q9ES34}.
Q7Z569 BRAP S117 ochoa BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}.
Q7Z5H3 ARHGAP22 S359 ochoa|psp Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}.
Q7Z6G3 NECAB2 S57 ochoa N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2) May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}.
Q86TG7 PEG10 S252 ochoa Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein) Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity). {ECO:0000250|UniProtKB:Q7TN75, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:26235627, ECO:0000269|PubMed:28193232, ECO:0000269|PubMed:30094509, ECO:0000269|PubMed:34413232}.
Q86UW9 DTX2 S360 ochoa Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Q86X10 RALGAPB S921 ochoa Ral GTPase-activating protein subunit beta (p170) Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q86Y97 KMT5C S439 ochoa Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q6Q783, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}.
Q8IW19 APLF S131 ochoa Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) Histone chaperone involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:21211722, PubMed:29905837, PubMed:30104678). Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:30104678). Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:21211722, PubMed:29905837, PubMed:30104678). Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (PubMed:17353262, PubMed:17396150). Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721, PubMed:23689425). Also acts as a negative regulator of cell pluripotency by promoting histone exchange (By similarity). Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity). {ECO:0000250|UniProtKB:Q9D842, ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425, ECO:0000269|PubMed:29905837, ECO:0000269|PubMed:30104678}.
Q8IWU2 LMTK2 S630 ochoa Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) Phosphorylates PPP1C, phosphorylase b and CFTR.
Q8N3K9 CMYA5 S1283 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8N3V7 SYNPO S580 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8NBR9 NDUFV1-DT S42 ochoa Uncharacterized protein NDUFV1-DT (NDUFV1 divergent transcript) None
Q8ND82 ZNF280C S105 ochoa Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) May function as a transcription factor.
Q8NEZ4 KMT2C S3519 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8NHV4 NEDD1 S215 psp Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8TEK3 DOT1L S834 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q8TEK3 DOT1L S1001 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q92466 DDB2 S297 ochoa DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:32789493, PubMed:9892649). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:14751237, PubMed:16260596, PubMed:32789493). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:16260596). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825). {ECO:0000269|PubMed:10882109, ECO:0000269|PubMed:11278856, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:26572825, ECO:0000269|PubMed:32789493, ECO:0000269|PubMed:9892649}.; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.
Q92615 LARP4B S398 ochoa La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.
Q92674 CENPI S520 ochoa Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}.
Q92817 EVPL S1813 ochoa Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
Q96BD5 PHF21A S455 ochoa PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269|PubMed:16140033}.
Q96FZ5 CMTM7 S30 ochoa CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) None
Q96HB5 CCDC120 S286 ochoa Coiled-coil domain-containing protein 120 Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}.
Q96IF1 AJUBA S137 ochoa LIM domain-containing protein ajuba Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}.
Q96JM2 ZNF462 S350 ochoa Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}.
Q96KB5 PBK S32 ochoa|psp Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}.
Q96ME7 ZNF512 S319 ochoa Zinc finger protein 512 May be involved in transcriptional regulation.
Q96P47 AGAP3 S443 ochoa Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1) GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}.
Q99081 TCF12 S386 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99567 NUP88 S517 ochoa Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}.
Q99569 PKP4 S127 ochoa Plakophilin-4 (p0071) Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.
Q99640 PKMYT1 S416 psp Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
Q99990 VGLL1 S116 ochoa Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU) May act as a specific coactivator for the mammalian TEFs. {ECO:0000269|PubMed:10518497}.
Q9BRK5 SDF4 S209 ochoa 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
Q9BSQ5 CCM2 S164 ochoa Cerebral cavernous malformations 2 protein (Malcavernin) Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BWN1 PRR14 S277 ochoa Proline-rich protein 14 Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}.
Q9BZE0 GLIS2 S54 ochoa Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.
Q9C0C2 TNKS1BP1 S1297 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C7 AMBRA1 S52 psp Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}.
Q9C0H5 ARHGAP39 S366 ochoa Rho GTPase-activating protein 39 None
Q9H0F6 SHARPIN S165 ochoa|psp Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.
Q9H0W8 SMG9 S451 ochoa Nonsense-mediated mRNA decay factor SMG9 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}.
Q9H2J1 ARRDC1-AS1 S71 ochoa Uncharacterized protein ARRDC1-AS1 (ARRDC1 antisense RNA 1) (ARRDC1 antisense gene protein 1) None
Q9H2P0 ADNP S363 ochoa Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}.
Q9H2Y7 ZNF106 S661 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H2Y7 ZNF106 S727 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H611 PIF1 S151 ochoa ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}.
Q9H6E5 TUT1 S238 ochoa Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}.
Q9H792 PEAK1 S898 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9NPG3 UBN1 S821 ochoa Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
Q9NQW6 ANLN S182 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NQW6 ANLN S792 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NRM7 LATS2 S342 ochoa Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}.
Q9NS56 TOPORS S101 ochoa E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}.
Q9NWQ4 GPATCH2L S447 ochoa G patch domain-containing protein 2-like None
Q9NWZ5 UCKL1 S56 ochoa Uridine-cytidine kinase-like 1 (EC 2.7.1.48) May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}.
Q9NX95 SYBU S396 ochoa Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}.
Q9NYJ8 TAB2 S372 ochoa|psp TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}.
Q9NYV4 CDK12 S644 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9NZ52 GGA3 S559 psp ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}.
Q9P227 ARHGAP23 S554 ochoa Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9P275 USP36 S513 ochoa Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}.
Q9P2F5 STOX2 S172 ochoa Storkhead-box protein 2 None
Q9UBB9 TFIP11 S568 ochoa Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}.
Q9UBN7 HDAC6 S1035 psp Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}.
Q9UF83 None S519 ochoa Uncharacterized protein DKFZp434B061 None
Q9UJU6 DBNL S24 ochoa Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}.
Q9ULC8 ZDHHC8 S743 ochoa Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}.
Q9UM47 NOTCH3 S2117 ochoa Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250|UniProtKB:Q9R172, ECO:0000269|PubMed:15350543}.
Q9UNE0 EDAR S297 ochoa Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Q9UNZ2 NSFL1C S272 ochoa NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
Q9UPZ3 HPS5 S534 ochoa BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.
Q9Y2H5 PLEKHA6 S336 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y3M8 STARD13 S171 ochoa StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}.
Q9Y4B5 MTCL1 S1588 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y4F1 FARP1 S510 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y4R8 TELO2 S688 ochoa Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.
Q9Y613 FHOD1 S498 ochoa|psp FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}.
Q9Y6R4 MAP3K4 S1135 ochoa Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
Q8IZQ8 MYOCD S862 GPS6 Myocardin Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}.
Q9UNA1 ARHGAP26 S685 SIGNOR Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058). {ECO:0000269|PubMed:27512058, ECO:0000269|PubMed:38081847}.; FUNCTION: [Isoform 2]: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. {ECO:0000269|PubMed:32344433}.
Q03112 MECOM S726 SIGNOR Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.
O75928 PIAS2 S116 SIGNOR E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. {ECO:0000269|PubMed:15920481, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22406621}.
Download
reactome_id name p -log10_p
R-HSA-2428933 SHC-related events triggered by IGF1R 0.000721 3.142
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.001708 2.767
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.001804 2.744
R-HSA-3214841 PKMTs methylate histone lysines 0.001868 2.729
R-HSA-2028269 Signaling by Hippo 0.001789 2.747
R-HSA-9830364 Formation of the nephric duct 0.000374 3.427
R-HSA-9842663 Signaling by LTK 0.000721 3.142
R-HSA-166520 Signaling by NTRKs 0.000461 3.336
R-HSA-350054 Notch-HLH transcription pathway 0.003520 2.453
R-HSA-9031628 NGF-stimulated transcription 0.003240 2.489
R-HSA-9634597 GPER1 signaling 0.003240 2.489
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.003432 2.465
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.004313 2.365
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.004313 2.365
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.004626 2.335
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.007031 2.153
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.007031 2.153
R-HSA-9707616 Heme signaling 0.007054 2.152
R-HSA-8939211 ESR-mediated signaling 0.006770 2.169
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.006016 2.221
R-HSA-3247509 Chromatin modifying enzymes 0.006329 2.199
R-HSA-74749 Signal attenuation 0.008751 2.058
R-HSA-9830369 Kidney development 0.008925 2.049
R-HSA-4839726 Chromatin organization 0.008771 2.057
R-HSA-9034864 Activated NTRK3 signals through RAS 0.010079 1.997
R-HSA-9026519 Activated NTRK2 signals through RAS 0.011490 1.940
R-HSA-1989781 PPARA activates gene expression 0.011200 1.951
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.011795 1.928
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.011490 1.940
R-HSA-8941326 RUNX2 regulates bone development 0.011352 1.945
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.013580 1.867
R-HSA-3249367 STAT6-mediated induction of chemokines 0.052013 1.284
R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism 0.052013 1.284
R-HSA-8941237 Invadopodia formation 0.052013 1.284
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.062088 1.207
R-HSA-5083630 Defective LFNG causes SCDO3 0.062088 1.207
R-HSA-9652169 Signaling by MAP2K mutants 0.062088 1.207
R-HSA-9854909 Regulation of MITF-M dependent genes involved in invasion 0.072057 1.142
R-HSA-9818025 NFE2L2 regulating TCA cycle genes 0.072057 1.142
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.072057 1.142
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.081920 1.087
R-HSA-9017802 Noncanonical activation of NOTCH3 0.081920 1.087
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.081920 1.087
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.101336 0.994
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 0.101336 0.994
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.110890 0.955
R-HSA-8875656 MET receptor recycling 0.110890 0.955
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.120343 0.920
R-HSA-5654704 SHC-mediated cascade:FGFR3 0.031991 1.495
R-HSA-68952 DNA replication initiation 0.129696 0.887
R-HSA-5654719 SHC-mediated cascade:FGFR4 0.034263 1.465
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.036595 1.437
R-HSA-5654688 SHC-mediated cascade:FGFR1 0.041437 1.383
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.148106 0.829
R-HSA-202670 ERKs are inactivated 0.148106 0.829
R-HSA-69109 Leading Strand Synthesis 0.157166 0.804
R-HSA-69091 Polymerase switching 0.157166 0.804
R-HSA-5654699 SHC-mediated cascade:FGFR2 0.049120 1.309
R-HSA-170660 Adenylate cyclase activating pathway 0.166129 0.780
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.166129 0.780
R-HSA-9615710 Late endosomal microautophagy 0.054504 1.264
R-HSA-69166 Removal of the Flap Intermediate 0.174998 0.757
R-HSA-170670 Adenylate cyclase inhibitory pathway 0.183773 0.736
R-HSA-180336 SHC1 events in EGFR signaling 0.183773 0.736
R-HSA-1250347 SHC1 events in ERBB4 signaling 0.201046 0.697
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.217956 0.662
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.226277 0.645
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.258689 0.587
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 0.258689 0.587
R-HSA-912526 Interleukin receptor SHC signaling 0.266579 0.574
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.176137 0.754
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.176137 0.754
R-HSA-8854518 AURKA Activation by TPX2 0.187591 0.727
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.214680 0.668
R-HSA-380287 Centrosome maturation 0.222489 0.653
R-HSA-383280 Nuclear Receptor transcription pathway 0.234244 0.630
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.277551 0.557
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.166129 0.780
R-HSA-69186 Lagging Strand Synthesis 0.242655 0.615
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.250715 0.601
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.285426 0.545
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.064241 1.192
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.064241 1.192
R-HSA-9646399 Aggrephagy 0.090595 1.043
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.242655 0.615
R-HSA-69183 Processive synthesis on the lagging strand 0.183773 0.736
R-HSA-9730414 MITF-M-regulated melanocyte development 0.105855 0.975
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.064241 1.192
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.238171 0.623
R-HSA-2871796 FCERI mediated MAPK activation 0.147948 0.830
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.176137 0.754
R-HSA-191650 Regulation of gap junction activity 0.062088 1.207
R-HSA-110056 MAPK3 (ERK1) activation 0.129696 0.887
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 0.166129 0.780
R-HSA-9027284 Erythropoietin activates RAS 0.183773 0.736
R-HSA-174430 Telomere C-strand synthesis initiation 0.183773 0.736
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.028536 1.545
R-HSA-198753 ERK/MAPK targets 0.242655 0.615
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.114087 0.943
R-HSA-9649948 Signaling downstream of RAS mutants 0.114087 0.943
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.114087 0.943
R-HSA-112409 RAF-independent MAPK1/3 activation 0.258689 0.587
R-HSA-6802957 Oncogenic MAPK signaling 0.261789 0.582
R-HSA-9843745 Adipogenesis 0.073871 1.132
R-HSA-5619507 Activation of HOX genes during differentiation 0.036669 1.436
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.036669 1.436
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.049120 1.309
R-HSA-3214815 HDACs deacetylate histones 0.146227 0.835
R-HSA-5675221 Negative regulation of MAPK pathway 0.097150 1.013
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.093856 1.028
R-HSA-6802949 Signaling by RAS mutants 0.114087 0.943
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.113723 0.944
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.062088 1.207
R-HSA-69478 G2/M DNA replication checkpoint 0.091680 1.038
R-HSA-428543 Inactivation of CDC42 and RAC1 0.120343 0.920
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 0.129696 0.887
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.157166 0.804
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.183773 0.736
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.192456 0.716
R-HSA-164378 PKA activation in glucagon signalling 0.217956 0.662
R-HSA-167044 Signalling to RAS 0.242655 0.615
R-HSA-933542 TRAF6 mediated NF-kB activation 0.274385 0.562
R-HSA-73728 RNA Polymerase I Promoter Opening 0.297312 0.527
R-HSA-9613829 Chaperone Mediated Autophagy 0.025557 1.592
R-HSA-156711 Polo-like kinase mediated events 0.025557 1.592
R-HSA-170968 Frs2-mediated activation 0.166129 0.780
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.214374 0.669
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.289751 0.538
R-HSA-450341 Activation of the AP-1 family of transcription factors 0.120343 0.920
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 0.120343 0.920
R-HSA-8851805 MET activates RAS signaling 0.157166 0.804
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.174998 0.757
R-HSA-157118 Signaling by NOTCH 0.061583 1.211
R-HSA-5684996 MAPK1/MAPK3 signaling 0.250076 0.602
R-HSA-74751 Insulin receptor signalling cascade 0.179943 0.745
R-HSA-5673001 RAF/MAP kinase cascade 0.236254 0.627
R-HSA-8983432 Interleukin-15 signaling 0.157166 0.804
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.065464 1.184
R-HSA-187687 Signalling to ERKs 0.074835 1.126
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.150448 0.823
R-HSA-9732724 IFNG signaling activates MAPKs 0.101336 0.994
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.148106 0.829
R-HSA-8943724 Regulation of PTEN gene transcription 0.037078 1.431
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.242655 0.615
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.242655 0.615
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.076614 1.116
R-HSA-9018519 Estrogen-dependent gene expression 0.082674 1.083
R-HSA-169893 Prolonged ERK activation events 0.192456 0.716
R-HSA-1834941 STING mediated induction of host immune responses 0.226277 0.645
R-HSA-75893 TNF signaling 0.149906 0.824
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.274385 0.562
R-HSA-2428924 IGF1R signaling cascade 0.042698 1.370
R-HSA-392517 Rap1 signalling 0.226277 0.645
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.063684 1.196
R-HSA-450294 MAP kinase activation 0.168565 0.773
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.045659 1.340
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.217956 0.662
R-HSA-74752 Signaling by Insulin receptor 0.297223 0.527
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.044166 1.355
R-HSA-448424 Interleukin-17 signaling 0.203018 0.692
R-HSA-1980143 Signaling by NOTCH1 0.061927 1.208
R-HSA-9707587 Regulation of HMOX1 expression and activity 0.062088 1.207
R-HSA-9842640 Signaling by LTK in cancer 0.091680 1.038
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.019730 1.705
R-HSA-425986 Sodium/Proton exchangers 0.110890 0.955
R-HSA-444257 RSK activation 0.110890 0.955
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.157166 0.804
R-HSA-163615 PKA activation 0.217956 0.662
R-HSA-113510 E2F mediated regulation of DNA replication 0.226277 0.645
R-HSA-429947 Deadenylation of mRNA 0.274385 0.562
R-HSA-9839394 TGFBR3 expression 0.282109 0.550
R-HSA-9612973 Autophagy 0.284889 0.545
R-HSA-69275 G2/M Transition 0.070137 1.154
R-HSA-73886 Chromosome Maintenance 0.176152 0.754
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.138090 0.860
R-HSA-453274 Mitotic G2-G2/M phases 0.072428 1.140
R-HSA-9663891 Selective autophagy 0.277551 0.557
R-HSA-1266738 Developmental Biology 0.103733 0.984
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.209546 0.679
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.209546 0.679
R-HSA-9006931 Signaling by Nuclear Receptors 0.022683 1.644
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.034263 1.465
R-HSA-9909396 Circadian clock 0.211197 0.675
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 0.138950 0.857
R-HSA-9005895 Pervasive developmental disorders 0.157166 0.804
R-HSA-9697154 Disorders of Nervous System Development 0.157166 0.804
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.157166 0.804
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.250715 0.601
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.112253 0.950
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.257848 0.589
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.112253 0.950
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.112253 0.950
R-HSA-1236394 Signaling by ERBB4 0.058482 1.233
R-HSA-1643713 Signaling by EGFR in Cancer 0.289751 0.538
R-HSA-1169408 ISG15 antiviral mechanism 0.222489 0.653
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.140533 0.852
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.170915 0.767
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.170915 0.767
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.178788 0.748
R-HSA-180786 Extension of Telomeres 0.161052 0.793
R-HSA-1632852 Macroautophagy 0.239107 0.621
R-HSA-1251985 Nuclear signaling by ERBB4 0.090595 1.043
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.178788 0.748
R-HSA-5654708 Downstream signaling of activated FGFR3 0.054504 1.264
R-HSA-5654716 Downstream signaling of activated FGFR4 0.057271 1.242
R-HSA-5654696 Downstream signaling of activated FGFR2 0.074835 1.126
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.242655 0.615
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.242655 0.615
R-HSA-9627069 Regulation of the apoptosome activity 0.129696 0.887
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.166129 0.780
R-HSA-354192 Integrin signaling 0.065854 1.181
R-HSA-5654687 Downstream signaling of activated FGFR1 0.074835 1.126
R-HSA-9675151 Disorders of Developmental Biology 0.201046 0.697
R-HSA-2160916 Hyaluronan degradation 0.282109 0.550
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.282109 0.550
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.150448 0.823
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.158028 0.801
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.092678 1.033
R-HSA-5669034 TNFs bind their physiological receptors 0.274385 0.562
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.019190 1.717
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.261866 0.582
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.062947 1.201
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.110641 0.956
R-HSA-190236 Signaling by FGFR 0.112253 0.950
R-HSA-5654743 Signaling by FGFR4 0.017810 1.749
R-HSA-9635465 Suppression of apoptosis 0.138950 0.857
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.242655 0.615
R-HSA-525793 Myogenesis 0.289751 0.538
R-HSA-418555 G alpha (s) signalling events 0.147167 0.832
R-HSA-5654741 Signaling by FGFR3 0.019684 1.706
R-HSA-1640170 Cell Cycle 0.092195 1.035
R-HSA-69278 Cell Cycle, Mitotic 0.099785 1.001
R-HSA-162582 Signal Transduction 0.029659 1.528
R-HSA-1227986 Signaling by ERBB2 0.037078 1.431
R-HSA-5654738 Signaling by FGFR2 0.069092 1.161
R-HSA-8878171 Transcriptional regulation by RUNX1 0.124984 0.903
R-HSA-5654736 Signaling by FGFR1 0.031867 1.497
R-HSA-77111 Synthesis of Ketone Bodies 0.234510 0.630
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.157320 0.803
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.210785 0.676
R-HSA-6806834 Signaling by MET 0.242102 0.616
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.216274 0.665
R-HSA-8963896 HDL assembly 0.174998 0.757
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.226277 0.645
R-HSA-9020558 Interleukin-2 signaling 0.138950 0.857
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.049120 1.309
R-HSA-6794361 Neurexins and neuroligins 0.135308 0.869
R-HSA-3371556 Cellular response to heat stress 0.176152 0.754
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.110890 0.955
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.120343 0.920
R-HSA-9762292 Regulation of CDH11 function 0.129696 0.887
R-HSA-111458 Formation of apoptosome 0.129696 0.887
R-HSA-1502540 Signaling by Activin 0.183773 0.736
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.149906 0.824
R-HSA-196757 Metabolism of folate and pterines 0.081026 1.091
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.039647 1.402
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.164801 0.783
R-HSA-1295596 Spry regulation of FGF signaling 0.183773 0.736
R-HSA-445144 Signal transduction by L1 0.234510 0.630
R-HSA-74182 Ketone body metabolism 0.266579 0.574
R-HSA-9707564 Cytoprotection by HMOX1 0.074701 1.127
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.172344 0.764
R-HSA-6807070 PTEN Regulation 0.233472 0.632
R-HSA-8878166 Transcriptional regulation by RUNX2 0.170915 0.767
R-HSA-9700206 Signaling by ALK in cancer 0.039647 1.402
R-HSA-111461 Cytochrome c-mediated apoptotic response 0.148106 0.829
R-HSA-1181150 Signaling by NODAL 0.234510 0.630
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.266579 0.574
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.297312 0.527
R-HSA-9009391 Extra-nuclear estrogen signaling 0.032906 1.483
R-HSA-1538133 G0 and Early G1 0.062947 1.201
R-HSA-9733709 Cardiogenesis 0.065854 1.181
R-HSA-210993 Tie2 Signaling 0.217956 0.662
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.258689 0.587
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.289751 0.538
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.203018 0.692
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.282109 0.550
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.246035 0.609
R-HSA-6794362 Protein-protein interactions at synapses 0.261789 0.582
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.124587 0.905
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.062947 1.201
R-HSA-8963898 Plasma lipoprotein assembly 0.274385 0.562
R-HSA-201556 Signaling by ALK 0.087369 1.059
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.164801 0.783
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.164801 0.783
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.164801 0.783
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.164801 0.783
R-HSA-9006936 Signaling by TGFB family members 0.296468 0.528
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.107223 0.970
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.256147 0.592
R-HSA-111471 Apoptotic factor-mediated response 0.217956 0.662
R-HSA-982772 Growth hormone receptor signaling 0.266579 0.574
R-HSA-75153 Apoptotic execution phase 0.114087 0.943
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.164801 0.783
R-HSA-381038 XBP1(S) activates chaperone genes 0.269670 0.569
R-HSA-381070 IRE1alpha activates chaperones 0.293293 0.533
R-HSA-1852241 Organelle biogenesis and maintenance 0.298852 0.525
R-HSA-109581 Apoptosis 0.302270 0.520
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.304793 0.516
R-HSA-171319 Telomere Extension By Telomerase 0.304793 0.516
R-HSA-73614 Pyrimidine salvage 0.304793 0.516
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.312195 0.506
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.312195 0.506
R-HSA-9006335 Signaling by Erythropoietin 0.312195 0.506
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.312195 0.506
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.312195 0.506
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.312195 0.506
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.312195 0.506
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.319519 0.496
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.319519 0.496
R-HSA-2424491 DAP12 signaling 0.319519 0.496
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.319519 0.496
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.319519 0.496
R-HSA-68962 Activation of the pre-replicative complex 0.319519 0.496
R-HSA-157579 Telomere Maintenance 0.320719 0.494
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.320719 0.494
R-HSA-212436 Generic Transcription Pathway 0.321362 0.493
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.326765 0.486
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.326765 0.486
R-HSA-186763 Downstream signal transduction 0.326765 0.486
R-HSA-3214847 HATs acetylate histones 0.328512 0.483
R-HSA-69190 DNA strand elongation 0.333934 0.476
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.334242 0.476
R-HSA-5689880 Ub-specific processing proteases 0.337150 0.472
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.340156 0.468
R-HSA-1483255 PI Metabolism 0.340156 0.468
R-HSA-1855170 IPs transport between nucleus and cytosol 0.341028 0.467
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.341028 0.467
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.341028 0.467
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.341028 0.467
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.341028 0.467
R-HSA-159418 Recycling of bile acids and salts 0.341028 0.467
R-HSA-176187 Activation of ATR in response to replication stress 0.341028 0.467
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.341028 0.467
R-HSA-9022692 Regulation of MECP2 expression and activity 0.341028 0.467
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.341028 0.467
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.341028 0.467
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.348046 0.458
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.348046 0.458
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.348046 0.458
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.348046 0.458
R-HSA-163359 Glucagon signaling in metabolic regulation 0.348046 0.458
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.348046 0.458
R-HSA-5696400 Dual Incision in GG-NER 0.354990 0.450
R-HSA-180746 Nuclear import of Rev protein 0.354990 0.450
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.354990 0.450
R-HSA-168638 NOD1/2 Signaling Pathway 0.354990 0.450
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.354990 0.450
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.354990 0.450
R-HSA-2142845 Hyaluronan metabolism 0.354990 0.450
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.354990 0.450
R-HSA-5673000 RAF activation 0.354990 0.450
R-HSA-9768919 NPAS4 regulates expression of target genes 0.354990 0.450
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.354990 0.450
R-HSA-5683057 MAPK family signaling cascades 0.355351 0.449
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.355584 0.449
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.361860 0.441
R-HSA-2559585 Oncogene Induced Senescence 0.361860 0.441
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.361860 0.441
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.361860 0.441
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.367071 0.435
R-HSA-8853659 RET signaling 0.368658 0.433
R-HSA-3371511 HSF1 activation 0.368658 0.433
R-HSA-111933 Calmodulin induced events 0.368658 0.433
R-HSA-111997 CaM pathway 0.368658 0.433
R-HSA-9711123 Cellular response to chemical stress 0.369983 0.432
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.374686 0.426
R-HSA-166166 MyD88-independent TLR4 cascade 0.374686 0.426
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.375384 0.426
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.375384 0.426
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.375384 0.426
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.375384 0.426
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.375384 0.426
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.382038 0.418
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.382038 0.418
R-HSA-1483249 Inositol phosphate metabolism 0.382264 0.418
R-HSA-5617833 Cilium Assembly 0.386359 0.413
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.388622 0.410
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.388622 0.410
R-HSA-168898 Toll-like Receptor Cascades 0.389232 0.410
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.392103 0.407
R-HSA-68877 Mitotic Prometaphase 0.394970 0.403
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.395136 0.403
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.395136 0.403
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.395136 0.403
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.395136 0.403
R-HSA-177243 Interactions of Rev with host cellular proteins 0.395136 0.403
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.395136 0.403
R-HSA-451927 Interleukin-2 family signaling 0.395136 0.403
R-HSA-379726 Mitochondrial tRNA aminoacylation 0.395136 0.403
R-HSA-8982491 Glycogen metabolism 0.395136 0.403
R-HSA-909733 Interferon alpha/beta signaling 0.401034 0.397
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.401582 0.396
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 0.401582 0.396
R-HSA-9694548 Maturation of spike protein 0.401582 0.396
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.403551 0.394
R-HSA-5674135 MAP2K and MAPK activation 0.407959 0.389
R-HSA-9656223 Signaling by RAF1 mutants 0.407959 0.389
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.407959 0.389
R-HSA-9007101 Rab regulation of trafficking 0.408468 0.389
R-HSA-1592230 Mitochondrial biogenesis 0.408468 0.389
R-HSA-991365 Activation of GABAB receptors 0.414268 0.383
R-HSA-977444 GABA B receptor activation 0.414268 0.383
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.414268 0.383
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.414268 0.383
R-HSA-111996 Ca-dependent events 0.414268 0.383
R-HSA-389948 Co-inhibition by PD-1 0.414938 0.382
R-HSA-68875 Mitotic Prophase 0.419535 0.377
R-HSA-9710421 Defective pyroptosis 0.420510 0.376
R-HSA-8854214 TBC/RABGAPs 0.420510 0.376
R-HSA-9637690 Response of Mtb to phagocytosis 0.420510 0.376
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.423201 0.373
R-HSA-2172127 DAP12 interactions 0.426687 0.370
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.430497 0.366
R-HSA-68886 M Phase 0.431180 0.365
R-HSA-5357801 Programmed Cell Death 0.431887 0.365
R-HSA-2262752 Cellular responses to stress 0.432760 0.364
R-HSA-774815 Nucleosome assembly 0.432798 0.364
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.432798 0.364
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.432798 0.364
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.432798 0.364
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.432798 0.364
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.432798 0.364
R-HSA-1489509 DAG and IP3 signaling 0.432798 0.364
R-HSA-6809371 Formation of the cornified envelope 0.434127 0.362
R-HSA-5357905 Regulation of TNFR1 signaling 0.438844 0.358
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.438844 0.358
R-HSA-9839373 Signaling by TGFBR3 0.438844 0.358
R-HSA-9675135 Diseases of DNA repair 0.438844 0.358
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.444826 0.352
R-HSA-69481 G2/M Checkpoints 0.448522 0.348
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.450745 0.346
R-HSA-425410 Metal ion SLC transporters 0.450745 0.346
R-HSA-157858 Gap junction trafficking and regulation 0.456601 0.340
R-HSA-74160 Gene expression (Transcription) 0.465857 0.332
R-HSA-418990 Adherens junctions interactions 0.467975 0.330
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.468127 0.330
R-HSA-73857 RNA Polymerase II Transcription 0.469145 0.329
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.473799 0.324
R-HSA-8953897 Cellular responses to stimuli 0.477770 0.321
R-HSA-8956320 Nucleotide biosynthesis 0.479410 0.319
R-HSA-163685 Integration of energy metabolism 0.487020 0.312
R-HSA-9012852 Signaling by NOTCH3 0.490455 0.309
R-HSA-418597 G alpha (z) signalling events 0.490455 0.309
R-HSA-9705683 SARS-CoV-2-host interactions 0.495037 0.305
R-HSA-177929 Signaling by EGFR 0.495890 0.305
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.495890 0.305
R-HSA-381119 Unfolded Protein Response (UPR) 0.497229 0.303
R-HSA-212165 Epigenetic regulation of gene expression 0.499738 0.301
R-HSA-2980766 Nuclear Envelope Breakdown 0.501268 0.300
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.501268 0.300
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.510639 0.292
R-HSA-194441 Metabolism of non-coding RNA 0.511852 0.291
R-HSA-191859 snRNP Assembly 0.511852 0.291
R-HSA-429914 Deadenylation-dependent mRNA decay 0.511852 0.291
R-HSA-977443 GABA receptor activation 0.517060 0.286
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.517060 0.286
R-HSA-379724 tRNA Aminoacylation 0.517060 0.286
R-HSA-168325 Viral Messenger RNA Synthesis 0.522212 0.282
R-HSA-211976 Endogenous sterols 0.522212 0.282
R-HSA-445717 Aquaporin-mediated transport 0.522212 0.282
R-HSA-8956321 Nucleotide salvage 0.522212 0.282
R-HSA-112043 PLC beta mediated events 0.522212 0.282
R-HSA-6784531 tRNA processing in the nucleus 0.527311 0.278
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.527311 0.278
R-HSA-375165 NCAM signaling for neurite out-growth 0.527311 0.278
R-HSA-186797 Signaling by PDGF 0.527311 0.278
R-HSA-373755 Semaphorin interactions 0.532355 0.274
R-HSA-9679191 Potential therapeutics for SARS 0.536752 0.270
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.537345 0.270
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.539949 0.268
R-HSA-9006925 Intracellular signaling by second messengers 0.542034 0.266
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.542283 0.266
R-HSA-1234174 Cellular response to hypoxia 0.542283 0.266
R-HSA-73887 Death Receptor Signaling 0.549447 0.260
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.549447 0.260
R-HSA-112040 G-protein mediated events 0.552001 0.258
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.552001 0.258
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.552001 0.258
R-HSA-421270 Cell-cell junction organization 0.554550 0.256
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.556783 0.254
R-HSA-9694516 SARS-CoV-2 Infection 0.557158 0.254
R-HSA-5688426 Deubiquitination 0.564473 0.248
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.566195 0.247
R-HSA-388841 Regulation of T cell activation by CD28 family 0.566933 0.246
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.570827 0.243
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.570827 0.243
R-HSA-69620 Cell Cycle Checkpoints 0.571827 0.243
R-HSA-5578749 Transcriptional regulation by small RNAs 0.575409 0.240
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.579943 0.237
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.579943 0.237
R-HSA-9679506 SARS-CoV Infections 0.581766 0.235
R-HSA-69473 G2/M DNA damage checkpoint 0.584428 0.233
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.593256 0.227
R-HSA-3700989 Transcriptional Regulation by TP53 0.595450 0.225
R-HSA-9694635 Translation of Structural Proteins 0.597601 0.224
R-HSA-73864 RNA Polymerase I Transcription 0.601898 0.220
R-HSA-191273 Cholesterol biosynthesis 0.601898 0.220
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.609231 0.215
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.609231 0.215
R-HSA-76002 Platelet activation, signaling and aggregation 0.609737 0.215
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.610358 0.214
R-HSA-5693607 Processing of DNA double-strand break ends 0.614520 0.211
R-HSA-977225 Amyloid fiber formation 0.614520 0.211
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.614869 0.211
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.618639 0.209
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.618639 0.209
R-HSA-446728 Cell junction organization 0.618860 0.208
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.622713 0.206
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.626744 0.203
R-HSA-913531 Interferon Signaling 0.628570 0.202
R-HSA-2559583 Cellular Senescence 0.628691 0.202
R-HSA-141424 Amplification of signal from the kinetochores 0.634679 0.197
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.634679 0.197
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.634679 0.197
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.638583 0.195
R-HSA-438064 Post NMDA receptor activation events 0.642446 0.192
R-HSA-9645723 Diseases of programmed cell death 0.646267 0.190
R-HSA-202424 Downstream TCR signaling 0.653789 0.185
R-HSA-1257604 PIP3 activates AKT signaling 0.656018 0.183
R-HSA-8986944 Transcriptional Regulation by MECP2 0.657490 0.182
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.664774 0.177
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.664774 0.177
R-HSA-9609690 HCMV Early Events 0.670342 0.174
R-HSA-9837999 Mitochondrial protein degradation 0.671905 0.173
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.675413 0.170
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.682319 0.166
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.682319 0.166
R-HSA-422356 Regulation of insulin secretion 0.689078 0.162
R-HSA-449147 Signaling by Interleukins 0.691465 0.160
R-HSA-192105 Synthesis of bile acids and bile salts 0.692404 0.160
R-HSA-69618 Mitotic Spindle Checkpoint 0.695694 0.158
R-HSA-70171 Glycolysis 0.695694 0.158
R-HSA-5610787 Hedgehog 'off' state 0.695694 0.158
R-HSA-6805567 Keratinization 0.696742 0.157
R-HSA-1500931 Cell-Cell communication 0.698262 0.156
R-HSA-9020702 Interleukin-1 signaling 0.698950 0.156
R-HSA-2559580 Oxidative Stress Induced Senescence 0.702171 0.154
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.702171 0.154
R-HSA-111885 Opioid Signalling 0.708510 0.150
R-HSA-9860931 Response of endothelial cells to shear stress 0.708510 0.150
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.710396 0.148
R-HSA-9833110 RSV-host interactions 0.711629 0.148
R-HSA-5696398 Nucleotide Excision Repair 0.714715 0.146
R-HSA-69239 Synthesis of DNA 0.720789 0.142
R-HSA-211000 Gene Silencing by RNA 0.720789 0.142
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.726734 0.139
R-HSA-69002 DNA Replication Pre-Initiation 0.726734 0.139
R-HSA-194068 Bile acid and bile salt metabolism 0.729659 0.137
R-HSA-202403 TCR signaling 0.729659 0.137
R-HSA-8951664 Neddylation 0.729915 0.137
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.735417 0.133
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.735417 0.133
R-HSA-1280215 Cytokine Signaling in Immune system 0.738975 0.131
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.741052 0.130
R-HSA-9855142 Cellular responses to mechanical stimuli 0.741052 0.130
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.748314 0.126
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.749283 0.125
R-HSA-373760 L1CAM interactions 0.751968 0.124
R-HSA-70326 Glucose metabolism 0.754624 0.122
R-HSA-5693538 Homology Directed Repair 0.757253 0.121
R-HSA-15869 Metabolism of nucleotides 0.759977 0.119
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.764971 0.116
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.764971 0.116
R-HSA-112316 Neuronal System 0.769289 0.114
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.769980 0.114
R-HSA-162909 Host Interactions of HIV factors 0.772445 0.112
R-HSA-9675108 Nervous system development 0.774947 0.111
R-HSA-69206 G1/S Transition 0.777296 0.109
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.779683 0.108
R-HSA-9609646 HCMV Infection 0.785395 0.105
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.788978 0.103
R-HSA-9734767 Developmental Cell Lineages 0.806860 0.093
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.808492 0.092
R-HSA-5358351 Signaling by Hedgehog 0.810546 0.091
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.814590 0.089
R-HSA-9664407 Parasite infection 0.814590 0.089
R-HSA-9664417 Leishmania phagocytosis 0.814590 0.089
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.816579 0.088
R-HSA-162599 Late Phase of HIV Life Cycle 0.820494 0.086
R-HSA-2871837 FCERI mediated NF-kB activation 0.824326 0.084
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.830657 0.081
R-HSA-69242 S Phase 0.831747 0.080
R-HSA-9658195 Leishmania infection 0.833439 0.079
R-HSA-9824443 Parasitic Infection Pathways 0.833439 0.079
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.834815 0.078
R-HSA-9856651 MITF-M-dependent gene expression 0.835340 0.078
R-HSA-446652 Interleukin-1 family signaling 0.838857 0.076
R-HSA-69306 DNA Replication 0.840587 0.075
R-HSA-5693532 DNA Double-Strand Break Repair 0.840587 0.075
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.843993 0.074
R-HSA-9610379 HCMV Late Events 0.847326 0.072
R-HSA-162587 HIV Life Cycle 0.847326 0.072
R-HSA-877300 Interferon gamma signaling 0.850588 0.070
R-HSA-1483257 Phospholipid metabolism 0.851793 0.070
R-HSA-5633007 Regulation of TP53 Activity 0.852193 0.069
R-HSA-422475 Axon guidance 0.857535 0.067
R-HSA-2467813 Separation of Sister Chromatids 0.858443 0.066
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.862958 0.064
R-HSA-5619102 SLC transporter disorders 0.862958 0.064
R-HSA-72306 tRNA processing 0.868756 0.061
R-HSA-5621481 C-type lectin receptors (CLRs) 0.870167 0.060
R-HSA-9664433 Leishmania parasite growth and survival 0.872943 0.059
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.872943 0.059
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.874309 0.058
R-HSA-168255 Influenza Infection 0.880924 0.055
R-HSA-112315 Transmission across Chemical Synapses 0.883107 0.054
R-HSA-8957322 Metabolism of steroids 0.884104 0.053
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.885940 0.053
R-HSA-201681 TCF dependent signaling in response to WNT 0.885966 0.053
R-HSA-3781865 Diseases of glycosylation 0.887193 0.052
R-HSA-1630316 Glycosaminoglycan metabolism 0.897661 0.047
R-HSA-72163 mRNA Splicing - Major Pathway 0.898762 0.046
R-HSA-428157 Sphingolipid metabolism 0.906151 0.043
R-HSA-376176 Signaling by ROBO receptors 0.908162 0.042
R-HSA-72172 mRNA Splicing 0.910130 0.041
R-HSA-73894 DNA Repair 0.915176 0.038
R-HSA-196854 Metabolism of vitamins and cofactors 0.918103 0.037
R-HSA-68882 Mitotic Anaphase 0.921088 0.036
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.921939 0.035
R-HSA-9824446 Viral Infection Pathways 0.928734 0.032
R-HSA-199991 Membrane Trafficking 0.929665 0.032
R-HSA-162906 HIV Infection 0.929961 0.032
R-HSA-388396 GPCR downstream signalling 0.930213 0.031
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.931370 0.031
R-HSA-109582 Hemostasis 0.934722 0.029
R-HSA-202733 Cell surface interactions at the vascular wall 0.937164 0.028
R-HSA-1280218 Adaptive Immune System 0.942421 0.026
R-HSA-5619115 Disorders of transmembrane transporters 0.943629 0.025
R-HSA-597592 Post-translational protein modification 0.952825 0.021
R-HSA-416476 G alpha (q) signalling events 0.953138 0.021
R-HSA-211945 Phase I - Functionalization of compounds 0.959757 0.018
R-HSA-372790 Signaling by GPCR 0.960505 0.018
R-HSA-195721 Signaling by WNT 0.967633 0.014
R-HSA-1474244 Extracellular matrix organization 0.977417 0.010
R-HSA-5653656 Vesicle-mediated transport 0.978938 0.009
R-HSA-8953854 Metabolism of RNA 0.983002 0.007
R-HSA-556833 Metabolism of lipids 0.983542 0.007
R-HSA-9824439 Bacterial Infection Pathways 0.988286 0.005
R-HSA-425407 SLC-mediated transmembrane transport 0.989152 0.005
R-HSA-5663205 Infectious disease 0.990203 0.004
R-HSA-418594 G alpha (i) signalling events 0.990279 0.004
R-HSA-168256 Immune System 0.991740 0.004
R-HSA-5668914 Diseases of metabolism 0.992195 0.003
R-HSA-72766 Translation 0.992365 0.003
R-HSA-1643685 Disease 0.994141 0.003
R-HSA-6798695 Neutrophil degranulation 0.994389 0.002
R-HSA-392499 Metabolism of proteins 0.995322 0.002
R-HSA-168249 Innate Immune System 0.996878 0.001
R-HSA-211859 Biological oxidations 0.997291 0.001
R-HSA-382551 Transport of small molecules 0.998774 0.001
R-HSA-381753 Olfactory Signaling Pathway 0.999941 0.000
R-HSA-1430728 Metabolism 0.999996 0.000
R-HSA-9709957 Sensory Perception 0.999999 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDK19CDK19 0.863 0.881 1 0.827
CDK18CDK18 0.860 0.864 1 0.842
HIPK2HIPK2 0.857 0.792 1 0.820
CDK17CDK17 0.856 0.860 1 0.870
CDK8CDK8 0.855 0.877 1 0.792
P38GP38G 0.853 0.875 1 0.874
CDK7CDK7 0.850 0.847 1 0.796
CDK3CDK3 0.849 0.753 1 0.862
ERK1ERK1 0.848 0.878 1 0.819
JNK2JNK2 0.848 0.870 1 0.835
P38DP38D 0.847 0.861 1 0.881
P38BP38B 0.846 0.895 1 0.802
CDK1CDK1 0.845 0.824 1 0.819
CDK16CDK16 0.845 0.824 1 0.859
CDK13CDK13 0.843 0.820 1 0.818
CDK12CDK12 0.843 0.821 1 0.838
CDK5CDK5 0.842 0.813 1 0.770
KISKIS 0.841 0.708 1 0.768
DYRK2DYRK2 0.839 0.763 1 0.733
P38AP38A 0.836 0.876 1 0.736
JNK3JNK3 0.834 0.845 1 0.809
DYRK4DYRK4 0.834 0.754 1 0.828
CDK9CDK9 0.833 0.791 1 0.810
DYRK1BDYRK1B 0.830 0.727 1 0.792
HIPK4HIPK4 0.830 0.569 1 0.526
CDK10CDK10 0.830 0.751 1 0.821
HIPK1HIPK1 0.829 0.697 1 0.715
CDK14CDK14 0.828 0.793 1 0.804
CDK4CDK4 0.825 0.809 1 0.847
DYRK1ADYRK1A 0.825 0.663 1 0.701
ERK2ERK2 0.824 0.826 1 0.773
MAKMAK 0.823 0.663 -2 0.921
CLK3CLK3 0.823 0.511 1 0.501
CDK6CDK6 0.822 0.782 1 0.823
HIPK3HIPK3 0.821 0.685 1 0.686
JNK1JNK1 0.814 0.756 1 0.836
NLKNLK 0.813 0.715 1 0.528
SRPK1SRPK1 0.809 0.342 -3 0.714
CDK2CDK2 0.809 0.612 1 0.694
ERK5ERK5 0.808 0.449 1 0.439
ICKICK 0.806 0.514 -3 0.802
DYRK3DYRK3 0.806 0.536 1 0.678
MOKMOK 0.803 0.572 1 0.604
CDKL5CDKL5 0.803 0.301 -3 0.752
CLK2CLK2 0.798 0.382 -3 0.711
CLK1CLK1 0.795 0.378 -3 0.713
MTORMTOR 0.794 0.259 1 0.319
SRPK2SRPK2 0.793 0.261 -3 0.626
CDKL1CDKL1 0.792 0.238 -3 0.755
PRP4PRP4 0.790 0.477 -3 0.770
CLK4CLK4 0.788 0.332 -3 0.729
COTCOT 0.787 -0.049 2 0.846
TBK1TBK1 0.781 -0.073 1 0.118
SRPK3SRPK3 0.779 0.229 -3 0.668
PRKD1PRKD1 0.779 0.008 -3 0.805
NDR2NDR2 0.779 0.006 -3 0.817
CDC7CDC7 0.778 -0.053 1 0.143
MOSMOS 0.778 0.020 1 0.188
ERK7ERK7 0.777 0.291 2 0.545
CHAK2CHAK2 0.776 0.028 -1 0.824
PRPKPRPK 0.776 -0.032 -1 0.848
PIM3PIM3 0.775 -0.021 -3 0.801
IKKEIKKE 0.774 -0.121 1 0.117
MPSK1MPSK1 0.773 0.216 1 0.216
ATRATR 0.773 -0.010 1 0.195
PRKD2PRKD2 0.773 -0.002 -3 0.754
WNK1WNK1 0.772 -0.036 -2 0.763
NUAK2NUAK2 0.770 0.004 -3 0.810
PDHK4PDHK4 0.769 -0.120 1 0.202
NEK6NEK6 0.768 -0.073 -2 0.663
MST4MST4 0.768 -0.043 2 0.809
RAF1RAF1 0.768 -0.159 1 0.136
ULK2ULK2 0.768 -0.176 2 0.782
MLK2MLK2 0.768 -0.000 2 0.808
IKKBIKKB 0.766 -0.180 -2 0.606
MARK4MARK4 0.766 -0.044 4 0.834
NDR1NDR1 0.766 -0.058 -3 0.799
PKN3PKN3 0.766 -0.058 -3 0.782
PDHK1PDHK1 0.766 -0.143 1 0.180
CAMK1BCAMK1B 0.766 -0.064 -3 0.820
SKMLCKSKMLCK 0.765 -0.046 -2 0.721
PKCDPKCD 0.765 -0.023 2 0.760
AURCAURC 0.765 -0.006 -2 0.513
GCN2GCN2 0.765 -0.214 2 0.775
AMPKA1AMPKA1 0.765 -0.048 -3 0.825
IRE1IRE1 0.765 -0.038 1 0.146
TSSK1TSSK1 0.764 -0.026 -3 0.848
NIKNIK 0.764 -0.065 -3 0.839
BMPR2BMPR2 0.763 -0.195 -2 0.704
MAPKAPK3MAPKAPK3 0.763 -0.062 -3 0.745
PIM1PIM1 0.763 -0.001 -3 0.747
AMPKA2AMPKA2 0.762 -0.031 -3 0.792
IKKAIKKA 0.762 -0.087 -2 0.614
MNK2MNK2 0.762 -0.025 -2 0.642
RIPK3RIPK3 0.761 -0.106 3 0.753
GRK1GRK1 0.761 -0.033 -2 0.662
PKCZPKCZ 0.760 -0.010 2 0.773
PKN2PKN2 0.760 -0.081 -3 0.801
TSSK2TSSK2 0.760 -0.068 -5 0.846
DSTYKDSTYK 0.760 -0.189 2 0.841
CAMLCKCAMLCK 0.760 -0.044 -2 0.689
P90RSKP90RSK 0.760 -0.038 -3 0.736
MLK3MLK3 0.760 -0.004 2 0.706
ULK1ULK1 0.759 -0.166 -3 0.772
MLK1MLK1 0.759 -0.117 2 0.780
LATS2LATS2 0.759 -0.059 -5 0.742
BCKDKBCKDK 0.759 -0.136 -1 0.785
DAPK2DAPK2 0.758 -0.060 -3 0.827
DNAPKDNAPK 0.758 -0.024 1 0.192
MAPKAPK2MAPKAPK2 0.758 -0.045 -3 0.700
PKCBPKCB 0.757 -0.024 2 0.710
NEK7NEK7 0.757 -0.199 -3 0.803
RSK2RSK2 0.757 -0.049 -3 0.738
CAMK2GCAMK2G 0.757 -0.127 2 0.760
PRKD3PRKD3 0.757 -0.030 -3 0.713
WNK3WNK3 0.756 -0.173 1 0.142
IRE2IRE2 0.756 -0.043 2 0.751
PKACGPKACG 0.756 -0.066 -2 0.586
NIM1NIM1 0.756 -0.090 3 0.783
PKCGPKCG 0.756 -0.029 2 0.702
PKCAPKCA 0.756 -0.015 2 0.700
QSKQSK 0.756 -0.032 4 0.810
NUAK1NUAK1 0.756 -0.048 -3 0.748
PAK1PAK1 0.755 -0.049 -2 0.661
TGFBR2TGFBR2 0.755 -0.147 -2 0.586
NEK9NEK9 0.755 -0.167 2 0.817
MNK1MNK1 0.755 -0.022 -2 0.646
P70S6KBP70S6KB 0.755 -0.049 -3 0.752
PHKG1PHKG1 0.754 -0.070 -3 0.794
RSK3RSK3 0.754 -0.062 -3 0.721
MASTLMASTL 0.754 -0.164 -2 0.687
LATS1LATS1 0.754 0.003 -3 0.826
HUNKHUNK 0.754 -0.167 2 0.769
PAK3PAK3 0.754 -0.076 -2 0.648
CHAK1CHAK1 0.754 -0.077 2 0.791
MELKMELK 0.754 -0.082 -3 0.772
CAMK2DCAMK2D 0.754 -0.120 -3 0.805
GRK5GRK5 0.753 -0.167 -3 0.819
GRK7GRK7 0.753 -0.001 1 0.158
GSK3AGSK3A 0.753 0.200 4 0.432
ATMATM 0.752 -0.079 1 0.162
VRK2VRK2 0.752 0.079 1 0.238
RIPK1RIPK1 0.751 -0.178 1 0.129
PAK6PAK6 0.751 -0.038 -2 0.568
QIKQIK 0.750 -0.103 -3 0.799
PKACBPKACB 0.750 -0.021 -2 0.513
SGK3SGK3 0.750 -0.032 -3 0.730
NEK2NEK2 0.750 -0.123 2 0.807
PKG2PKG2 0.749 -0.043 -2 0.524
DLKDLK 0.749 -0.178 1 0.141
SIKSIK 0.749 -0.058 -3 0.722
PKRPKR 0.748 -0.086 1 0.163
BRSK2BRSK2 0.748 -0.079 -3 0.782
PINK1PINK1 0.748 0.124 1 0.362
AURBAURB 0.748 -0.047 -2 0.504
SMG1SMG1 0.747 -0.076 1 0.184
YSK4YSK4 0.747 -0.151 1 0.120
MARK3MARK3 0.747 -0.044 4 0.770
BMPR1BBMPR1B 0.746 -0.086 1 0.106
PRKXPRKX 0.746 -0.003 -3 0.662
BRSK1BRSK1 0.746 -0.068 -3 0.752
AKT2AKT2 0.746 -0.014 -3 0.654
CAMK4CAMK4 0.746 -0.147 -3 0.784
RSK4RSK4 0.746 -0.033 -3 0.710
MSK2MSK2 0.746 -0.080 -3 0.699
FAM20CFAM20C 0.745 -0.019 2 0.578
SSTKSSTK 0.745 -0.037 4 0.814
PKCHPKCH 0.745 -0.074 2 0.699
ANKRD3ANKRD3 0.744 -0.215 1 0.152
IRAK4IRAK4 0.744 -0.087 1 0.127
TTBK2TTBK2 0.744 -0.189 2 0.683
MLK4MLK4 0.744 -0.077 2 0.699
ALK4ALK4 0.743 -0.114 -2 0.630
WNK4WNK4 0.743 -0.081 -2 0.761
PAK2PAK2 0.743 -0.093 -2 0.641
TAO3TAO3 0.743 -0.009 1 0.168
PIM2PIM2 0.743 -0.015 -3 0.707
CAMK2ACAMK2A 0.742 -0.059 2 0.734
TGFBR1TGFBR1 0.742 -0.106 -2 0.605
MARK2MARK2 0.742 -0.067 4 0.734
DCAMKL1DCAMKL1 0.741 -0.062 -3 0.761
CAMK2BCAMK2B 0.741 -0.097 2 0.729
MEK1MEK1 0.741 -0.161 2 0.825
GRK6GRK6 0.740 -0.185 1 0.126
CHK1CHK1 0.740 -0.083 -3 0.787
PLK4PLK4 0.740 -0.132 2 0.624
PKCTPKCT 0.740 -0.071 2 0.714
MST3MST3 0.740 -0.056 2 0.799
AKT1AKT1 0.739 -0.031 -3 0.677
TLK2TLK2 0.738 -0.147 1 0.138
CK1ECK1E 0.738 -0.008 -3 0.558
NEK5NEK5 0.738 -0.124 1 0.142
MEK5MEK5 0.738 -0.135 2 0.811
MEKK1MEKK1 0.737 -0.143 1 0.148
MSK1MSK1 0.737 -0.073 -3 0.701
GRK4GRK4 0.737 -0.204 -2 0.651
PKCIPKCI 0.737 -0.048 2 0.737
PHKG2PHKG2 0.737 -0.090 -3 0.766
MARK1MARK1 0.736 -0.092 4 0.799
ZAKZAK 0.736 -0.153 1 0.124
MEKK2MEKK2 0.736 -0.116 2 0.795
MYLK4MYLK4 0.736 -0.088 -2 0.607
PLK1PLK1 0.736 -0.194 -2 0.594
SNRKSNRK 0.736 -0.171 2 0.679
PAK5PAK5 0.735 -0.061 -2 0.527
LKB1LKB1 0.735 -0.022 -3 0.806
BUB1BUB1 0.735 0.034 -5 0.770
HASPINHASPIN 0.735 0.070 -1 0.733
MAP3K15MAP3K15 0.734 -0.025 1 0.139
CAMK1GCAMK1G 0.734 -0.095 -3 0.712
PKACAPKACA 0.733 -0.042 -2 0.470
HRIHRI 0.732 -0.184 -2 0.659
ACVR2AACVR2A 0.732 -0.157 -2 0.578
GCKGCK 0.732 -0.039 1 0.152
PERKPERK 0.732 -0.192 -2 0.646
ACVR2BACVR2B 0.732 -0.153 -2 0.591
TAO2TAO2 0.732 -0.044 2 0.818
AURAAURA 0.732 -0.076 -2 0.474
BRAFBRAF 0.731 -0.150 -4 0.795
PAK4PAK4 0.731 -0.054 -2 0.532
HGKHGK 0.731 -0.040 3 0.911
KHS1KHS1 0.731 0.002 1 0.148
NEK11NEK11 0.731 -0.117 1 0.163
MAPKAPK5MAPKAPK5 0.731 -0.134 -3 0.655
DCAMKL2DCAMKL2 0.731 -0.081 -3 0.782
GSK3BGSK3B 0.731 0.037 4 0.424
GRK2GRK2 0.731 -0.114 -2 0.560
PBKPBK 0.730 -0.012 1 0.183
DRAK1DRAK1 0.730 -0.170 1 0.104
ALK2ALK2 0.730 -0.140 -2 0.605
PDK1PDK1 0.730 -0.068 1 0.178
TNIKTNIK 0.730 -0.025 3 0.907
PKN1PKN1 0.729 -0.060 -3 0.685
MEKK3MEKK3 0.729 -0.198 1 0.138
SBKSBK 0.729 0.073 -3 0.538
PKCEPKCE 0.729 -0.031 2 0.688
LRRK2LRRK2 0.728 0.007 2 0.826
KHS2KHS2 0.728 0.010 1 0.161
MEKK6MEKK6 0.728 -0.074 1 0.145
SMMLCKSMMLCK 0.728 -0.083 -3 0.771
CAMKK2CAMKK2 0.728 -0.123 -2 0.635
NEK4NEK4 0.728 -0.134 1 0.131
AKT3AKT3 0.728 -0.024 -3 0.597
CK1DCK1D 0.727 -0.008 -3 0.514
TLK1TLK1 0.727 -0.179 -2 0.624
MINKMINK 0.727 -0.091 1 0.129
HPK1HPK1 0.726 -0.065 1 0.152
PASKPASK 0.726 -0.062 -3 0.824
EEF2KEEF2K 0.726 -0.024 3 0.886
LOKLOK 0.726 -0.072 -2 0.646
PLK3PLK3 0.726 -0.176 2 0.725
P70S6KP70S6K 0.725 -0.085 -3 0.655
GAKGAK 0.725 -0.073 1 0.196
CAMKK1CAMKK1 0.725 -0.186 -2 0.619
SGK1SGK1 0.725 -0.008 -3 0.571
BMPR1ABMPR1A 0.724 -0.119 1 0.097
SLKSLK 0.722 -0.061 -2 0.615
CK1G1CK1G1 0.722 -0.070 -3 0.539
CAMK1DCAMK1D 0.722 -0.079 -3 0.653
MST2MST2 0.722 -0.136 1 0.133
NEK8NEK8 0.721 -0.191 2 0.797
NEK1NEK1 0.720 -0.130 1 0.123
ROCK2ROCK2 0.720 -0.037 -3 0.756
VRK1VRK1 0.720 -0.107 2 0.837
DAPK3DAPK3 0.718 -0.081 -3 0.764
CK1A2CK1A2 0.718 -0.038 -3 0.510
YSK1YSK1 0.717 -0.101 2 0.789
MRCKBMRCKB 0.717 -0.047 -3 0.699
TTBK1TTBK1 0.716 -0.185 2 0.598
MRCKAMRCKA 0.716 -0.058 -3 0.713
MST1MST1 0.715 -0.137 1 0.126
CK2A2CK2A2 0.715 -0.082 1 0.093
IRAK1IRAK1 0.715 -0.239 -1 0.740
CHK2CHK2 0.715 -0.063 -3 0.604
CAMK1ACAMK1A 0.715 -0.065 -3 0.621
BIKEBIKE 0.714 -0.024 1 0.191
PDHK3_TYRPDHK3_TYR 0.714 0.211 4 0.898
GRK3GRK3 0.713 -0.124 -2 0.515
AAK1AAK1 0.712 0.010 1 0.202
NEK3NEK3 0.712 -0.130 1 0.149
TAO1TAO1 0.711 -0.058 1 0.141
TAK1TAK1 0.711 -0.207 1 0.129
DMPK1DMPK1 0.711 -0.016 -3 0.730
LIMK2_TYRLIMK2_TYR 0.710 0.163 -3 0.862
PKG1PKG1 0.709 -0.076 -2 0.441
DAPK1DAPK1 0.709 -0.095 -3 0.744
STK33STK33 0.709 -0.141 2 0.584
MYO3BMYO3B 0.708 -0.058 2 0.809
MEK2MEK2 0.707 -0.198 2 0.812
ASK1ASK1 0.707 -0.087 1 0.137
CK2A1CK2A1 0.707 -0.089 1 0.084
OSR1OSR1 0.707 -0.076 2 0.797
TESK1_TYRTESK1_TYR 0.706 0.077 3 0.894
ROCK1ROCK1 0.706 -0.054 -3 0.713
RIPK2RIPK2 0.705 -0.235 1 0.111
PKMYT1_TYRPKMYT1_TYR 0.704 0.135 3 0.856
CRIKCRIK 0.704 -0.035 -3 0.679
PDHK4_TYRPDHK4_TYR 0.704 0.081 2 0.846
MYO3AMYO3A 0.703 -0.082 1 0.153
MAP2K4_TYRMAP2K4_TYR 0.699 0.006 -1 0.865
MAP2K7_TYRMAP2K7_TYR 0.697 -0.060 2 0.827
TTKTTK 0.696 -0.131 -2 0.618
MAP2K6_TYRMAP2K6_TYR 0.696 0.003 -1 0.867
LIMK1_TYRLIMK1_TYR 0.696 0.029 2 0.836
ALPHAK3ALPHAK3 0.695 -0.083 -1 0.766
PLK2PLK2 0.695 -0.131 -3 0.707
NEK10_TYRNEK10_TYR 0.694 -0.050 1 0.145
PDHK1_TYRPDHK1_TYR 0.694 -0.013 -1 0.860
TNNI3K_TYRTNNI3K_TYR 0.693 0.012 1 0.176
JAK2JAK2 0.693 -0.071 1 0.166
PINK1_TYRPINK1_TYR 0.692 -0.137 1 0.190
BMPR2_TYRBMPR2_TYR 0.692 -0.027 -1 0.860
RETRET 0.692 -0.108 1 0.159
TYK2TYK2 0.691 -0.151 1 0.148
JAK1JAK1 0.689 -0.043 1 0.138
CSF1RCSF1R 0.689 -0.046 3 0.815
MST1RMST1R 0.689 -0.079 3 0.826
ROS1ROS1 0.688 -0.083 3 0.803
JAK3JAK3 0.688 -0.084 1 0.147
STLK3STLK3 0.687 -0.171 1 0.112
TNK1TNK1 0.687 -0.019 3 0.799
YANK3YANK3 0.683 -0.077 2 0.359
TYRO3TYRO3 0.683 -0.140 3 0.831
EPHB4EPHB4 0.682 -0.095 -1 0.798
DDR1DDR1 0.682 -0.106 4 0.819
CK1ACK1A 0.682 -0.059 -3 0.425
EPHA6EPHA6 0.681 -0.104 -1 0.827
ABL2ABL2 0.680 -0.102 -1 0.757
TXKTXK 0.679 -0.075 1 0.101
TNK2TNK2 0.678 -0.074 3 0.755
FGFR1FGFR1 0.678 -0.047 3 0.772
INSRRINSRR 0.676 -0.124 3 0.757
DDR2DDR2 0.676 0.002 3 0.736
FGFR2FGFR2 0.676 -0.066 3 0.780
YES1YES1 0.676 -0.110 -1 0.779
ABL1ABL1 0.675 -0.116 -1 0.747
KDRKDR 0.675 -0.094 3 0.766
KITKIT 0.674 -0.118 3 0.809
PDGFRBPDGFRB 0.673 -0.181 3 0.830
LCKLCK 0.673 -0.099 -1 0.774
FGRFGR 0.672 -0.194 1 0.122
TEKTEK 0.672 -0.053 3 0.743
PDGFRAPDGFRA 0.671 -0.167 3 0.829
WEE1_TYRWEE1_TYR 0.670 -0.082 -1 0.730
HCKHCK 0.670 -0.159 -1 0.770
ITKITK 0.670 -0.135 -1 0.750
BLKBLK 0.669 -0.094 -1 0.770
METMET 0.669 -0.100 3 0.793
FLT3FLT3 0.668 -0.182 3 0.824
EPHB1EPHB1 0.667 -0.169 1 0.104
EPHA4EPHA4 0.667 -0.110 2 0.711
FERFER 0.666 -0.219 1 0.129
EPHB3EPHB3 0.665 -0.171 -1 0.774
AXLAXL 0.665 -0.178 3 0.782
EPHB2EPHB2 0.664 -0.156 -1 0.769
BMXBMX 0.664 -0.115 -1 0.671
ALKALK 0.664 -0.149 3 0.737
SRMSSRMS 0.664 -0.200 1 0.100
FGFR3FGFR3 0.663 -0.092 3 0.751
INSRINSR 0.663 -0.134 3 0.738
MERTKMERTK 0.662 -0.171 3 0.773
FYNFYN 0.661 -0.103 -1 0.757
FLT1FLT1 0.658 -0.156 -1 0.810
BTKBTK 0.658 -0.219 -1 0.702
TECTEC 0.657 -0.173 -1 0.678
LTKLTK 0.657 -0.180 3 0.748
ERBB2ERBB2 0.657 -0.186 1 0.125
FLT4FLT4 0.657 -0.167 3 0.748
FRKFRK 0.657 -0.161 -1 0.769
EPHA7EPHA7 0.656 -0.142 2 0.724
EGFREGFR 0.656 -0.119 1 0.094
EPHA1EPHA1 0.656 -0.169 3 0.775
NTRK1NTRK1 0.655 -0.227 -1 0.787
NTRK2NTRK2 0.655 -0.219 3 0.762
PTK6PTK6 0.655 -0.215 -1 0.692
NTRK3NTRK3 0.654 -0.160 -1 0.741
LYNLYN 0.653 -0.158 3 0.730
CK1G3CK1G3 0.653 -0.081 -3 0.378
EPHA3EPHA3 0.652 -0.169 2 0.690
MUSKMUSK 0.651 -0.142 1 0.086
MATKMATK 0.650 -0.124 -1 0.684
SRCSRC 0.650 -0.143 -1 0.744
PTK2BPTK2B 0.649 -0.142 -1 0.722
CSKCSK 0.649 -0.134 2 0.724
YANK2YANK2 0.648 -0.097 2 0.374
FGFR4FGFR4 0.647 -0.125 -1 0.734
EPHA8EPHA8 0.645 -0.148 -1 0.753
EPHA5EPHA5 0.645 -0.174 2 0.700
PTK2PTK2 0.644 -0.087 -1 0.781
SYKSYK 0.643 -0.118 -1 0.755
ERBB4ERBB4 0.642 -0.108 1 0.095
IGF1RIGF1R 0.641 -0.153 3 0.665
EPHA2EPHA2 0.636 -0.152 -1 0.732
ZAP70ZAP70 0.636 -0.082 -1 0.691
CK1G2CK1G2 0.631 -0.088 -3 0.463
FESFES 0.624 -0.163 -1 0.653