Motif 517 (n=112)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J1V8 | PPAN-P2RY11 | S359 | ochoa | HCG2039996 (PPAN-P2RY11 readthrough) | None |
| H0YC42 | None | S151 | ochoa | Tumor protein D52 | None |
| O75122 | CLASP2 | S22 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75369 | FLNB | S2127 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75533 | SF3B1 | S322 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75563 | SKAP2 | S101 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O75781 | PALM | S138 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O95235 | KIF20A | S61 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95436 | SLC34A2 | S671 | ochoa | Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) | Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}. |
| O95613 | PCNT | S2318 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95671 | ASMTL | S246 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| P11362 | FGFR1 | S447 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P11388 | TOP2A | S1387 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12270 | TPR | S646 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P16949 | STMN1 | S31 | ochoa | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P22626 | HNRNPA2B1 | S85 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23634 | ATP2B4 | S1162 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P25054 | APC | S1044 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P31942 | HNRNPH3 | S56 | ochoa | Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) | Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. |
| P38398 | BRCA1 | S889 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P46013 | MKI67 | S1291 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49916 | LIG3 | S472 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P61266 | STX1B | S58 | ochoa | Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2) | Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). {ECO:0000250}. |
| Q01814 | ATP2B2 | S1163 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q03164 | KMT2A | S504 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05084 | ICA1 | S291 | ochoa | Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) | May play a role in neurotransmitter secretion. {ECO:0000250}. |
| Q05209 | PTPN12 | S719 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q12888 | TP53BP1 | S119 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S623 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12972 | PPP1R8 | S249 | ochoa | Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)] | Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; FUNCTION: Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. |
| Q13112 | CHAF1B | S451 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13207 | TBX2 | S379 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13415 | ORC1 | S196 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13428 | TCOF1 | S1190 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14151 | SAFB2 | S195 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14151 | SAFB2 | S276 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14247 | CTTN | S432 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14511 | NEDD9 | S312 | ochoa | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q14596 | NBR1 | S673 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q15303 | ERBB4 | S1129 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q15424 | SAFB | S277 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15652 | JMJD1C | S1982 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q16512 | PKN1 | S301 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q16623 | STX1A | S59 | ochoa | Syntaxin-1A (Neuron-specific antigen HPC-1) | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}. |
| Q2NKX8 | ERCC6L | S1134 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2TB10 | ZNF800 | S174 | ochoa | Zinc finger protein 800 | May be involved in transcriptional regulation. |
| Q32MZ4 | LRRFIP1 | S536 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q5BKX6 | SLC45A4 | S333 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5JRA6 | MIA3 | S1702 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5TCZ1 | SH3PXD2A | Y553 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VST9 | OBSCN | S6942 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q68EM7 | ARHGAP17 | S551 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q69YH5 | CDCA2 | S955 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6IBW4 | NCAPH2 | S284 | ochoa|psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6IC98 | GRAMD4 | S33 | ochoa | GRAM domain-containing protein 4 (Death-inducing protein) | Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity). {ECO:0000250|UniProtKB:Q8CB44, ECO:0000269|PubMed:15565177}. |
| Q6VY07 | PACS1 | S423 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZRV2 | FAM83H | S942 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZS11 | RINL | S218 | ochoa | Ras and Rab interactor-like protein | Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity). {ECO:0000250}. |
| Q6ZW31 | SYDE1 | S59 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q71U36 | TUBA1A | S165 | psp | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z5J4 | RAI1 | S873 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86U44 | METTL3 | S64 | ochoa | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86VP1 | TAX1BP1 | S138 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q8IWE5 | PLEKHM2 | S441 | ochoa | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) | Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}. |
| Q8N344 | MIER2 | S181 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N3K9 | CMYA5 | S362 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N3R9 | PALS1 | S245 | ochoa | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}. |
| Q8N8A6 | DDX51 | S103 | ochoa | ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51) | ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. {ECO:0000250}. |
| Q8N8E2 | ZNF513 | S96 | ochoa | Zinc finger protein 513 | Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}. |
| Q8NDI1 | EHBP1 | S302 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NF50 | DOCK8 | S2077 | ochoa|psp | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8NFJ5 | GPRC5A | S336 | ochoa | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}. |
| Q8TD26 | CHD6 | S2680 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8WUB8 | PHF10 | S270 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WUZ0 | BCL7C | S156 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
| Q8WXA9 | SREK1 | S171 | ochoa | Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) | Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}. |
| Q96EH3 | MALSU1 | S82 | ochoa | Mitochondrial assembly of ribosomal large subunit protein 1 | Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable). {ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22238376, ECO:0000269|PubMed:23171548, ECO:0000305|PubMed:22829778, ECO:0000305|PubMed:28892042}. |
| Q96I25 | RBM17 | S169 | ochoa | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96KM6 | ZNF512B | S679 | ochoa | Zinc finger protein 512B | Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}. |
| Q96PE2 | ARHGEF17 | S2011 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96QT4 | TRPM7 | S1569 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T17 | MAP7D2 | S653 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q96T58 | SPEN | S2305 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99661 | KIF2C | S115 | ochoa|psp | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99959 | PKP2 | S183 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQE3 | TUBA1C | S165 | psp | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BSJ8 | ESYT1 | S963 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BUR5 | APOO | S65 | ochoa | MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:24743151, ECO:0000269|PubMed:25764979}. |
| Q9BX66 | SORBS1 | S697 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9C0C2 | TNKS1BP1 | S221 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H2Y7 | ZNF106 | S556 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9HBI1 | PARVB | S54 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
| Q9HCM7 | FBRSL1 | S844 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NQ55 | PPAN | S359 | ochoa | Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) | May have a role in cell growth. |
| Q9NRS6 | SNX15 | S194 | ochoa | Sorting nexin-15 | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}. |
| Q9P244 | LRFN1 | S646 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P275 | USP36 | S646 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2Y5 | UVRAG | S522 | ochoa|psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UDY2 | TJP2 | S953 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHY1 | NRBP1 | S428 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UJD0 | RIMS3 | S116 | ochoa | Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) | Regulates synaptic membrane exocytosis. {ECO:0000250}. |
| Q9UK61 | TASOR | S1195 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9ULH0 | KIDINS220 | S1296 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9Y572 | RIPK3 | S241 | ochoa | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y5K6 | CD2AP | S469 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y6I9 | TEX264 | S264 | ochoa | Testis-expressed protein 264 (Putative secreted protein Zsig11) | Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:32152270}. |
| Q9C0C7 | AMBRA1 | S465 | PSP | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
| Q7Z4S6 | KIF21A | S705 | Sugiyama | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| O00267 | SUPT5H | S818 | Sugiyama | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| P62913 | RPL11 | S51 | Sugiyama | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}. |
| Q8N568 | DCLK2 | S143 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q9UK32 | RPS6KA6 | S19 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.000002 | 5.647 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.000051 | 4.293 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.000097 | 4.011 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.000120 | 3.921 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.000201 | 3.696 |
| R-HSA-983189 | Kinesins | 0.000215 | 3.668 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.000201 | 3.696 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.000201 | 3.696 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.000272 | 3.565 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.000287 | 3.542 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.000410 | 3.387 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.000480 | 3.319 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.000640 | 3.194 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.000639 | 3.195 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.000640 | 3.194 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000621 | 3.207 |
| R-HSA-1640170 | Cell Cycle | 0.000607 | 3.216 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 0.000740 | 3.131 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000733 | 3.135 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.000893 | 3.049 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 0.001436 | 2.843 |
| R-HSA-1632852 | Macroautophagy | 0.001613 | 2.792 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.001627 | 2.789 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.001774 | 2.751 |
| R-HSA-9620244 | Long-term potentiation | 0.001946 | 2.711 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.002114 | 2.675 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.002738 | 2.563 |
| R-HSA-9612973 | Autophagy | 0.002603 | 2.585 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.002760 | 2.559 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003474 | 2.459 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.004112 | 2.386 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.004377 | 2.359 |
| R-HSA-68886 | M Phase | 0.004600 | 2.337 |
| R-HSA-5682910 | LGI-ADAM interactions | 0.005541 | 2.256 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.006329 | 2.199 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.006329 | 2.199 |
| R-HSA-9646399 | Aggrephagy | 0.006196 | 2.208 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.006329 | 2.199 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.006401 | 2.194 |
| R-HSA-68877 | Mitotic Prometaphase | 0.006710 | 2.173 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.007794 | 2.108 |
| R-HSA-9663891 | Selective autophagy | 0.007365 | 2.133 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.009337 | 2.030 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.008976 | 2.047 |
| R-HSA-437239 | Recycling pathway of L1 | 0.009492 | 2.023 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.009713 | 2.013 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.009950 | 2.002 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.010172 | 1.993 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.010675 | 1.972 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.013139 | 1.881 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.014288 | 1.845 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.013139 | 1.881 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.014288 | 1.845 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.013139 | 1.881 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.014625 | 1.835 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.015528 | 1.809 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.015528 | 1.809 |
| R-HSA-9692912 | SARS-CoV-1 targets PDZ proteins in cell-cell junction | 0.015528 | 1.809 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.016711 | 1.777 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.016711 | 1.777 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.016711 | 1.777 |
| R-HSA-5619045 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | 0.023203 | 1.634 |
| R-HSA-5687583 | Defective SLC34A2 causes PALM | 0.023203 | 1.634 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.022036 | 1.657 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.023464 | 1.630 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.023464 | 1.630 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.020647 | 1.685 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.023145 | 1.636 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.022625 | 1.645 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.018741 | 1.727 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.019296 | 1.715 |
| R-HSA-373760 | L1CAM interactions | 0.019553 | 1.709 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.020541 | 1.687 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.023145 | 1.636 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.018669 | 1.729 |
| R-HSA-8848021 | Signaling by PTK6 | 0.018669 | 1.729 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.020647 | 1.685 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.024928 | 1.603 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.024928 | 1.603 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.024928 | 1.603 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.027966 | 1.553 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.027966 | 1.553 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.029537 | 1.530 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.029537 | 1.530 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.030757 | 1.512 |
| R-HSA-3295583 | TRP channels | 0.026429 | 1.578 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.029537 | 1.530 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.027629 | 1.559 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.027712 | 1.557 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.029477 | 1.531 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.031143 | 1.507 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.038374 | 1.416 |
| R-HSA-8941237 | Invadopodia formation | 0.038374 | 1.416 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.038124 | 1.419 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.038124 | 1.419 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.034457 | 1.463 |
| R-HSA-427589 | Type II Na+/Pi cotransporters | 0.038374 | 1.416 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.037900 | 1.421 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.037900 | 1.421 |
| R-HSA-112316 | Neuronal System | 0.038934 | 1.410 |
| R-HSA-68882 | Mitotic Anaphase | 0.038660 | 1.413 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.039249 | 1.406 |
| R-HSA-1538133 | G0 and Early G1 | 0.036162 | 1.442 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.032783 | 1.484 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.036926 | 1.433 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.036162 | 1.442 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.040583 | 1.392 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.041202 | 1.385 |
| R-HSA-190861 | Gap junction assembly | 0.041470 | 1.382 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.043300 | 1.364 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.045160 | 1.345 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.045871 | 1.338 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.045871 | 1.338 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.045871 | 1.338 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.046866 | 1.329 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.050913 | 1.293 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.050913 | 1.293 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.053311 | 1.273 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.068018 | 1.167 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.052886 | 1.277 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.052886 | 1.277 |
| R-HSA-167169 | HIV Transcription Elongation | 0.052886 | 1.277 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.053311 | 1.273 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.053311 | 1.273 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.057155 | 1.243 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.060693 | 1.217 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.060693 | 1.217 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.060693 | 1.217 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.060693 | 1.217 |
| R-HSA-190828 | Gap junction trafficking | 0.063146 | 1.200 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.056913 | 1.245 |
| R-HSA-75153 | Apoptotic execution phase | 0.067424 | 1.171 |
| R-HSA-444257 | RSK activation | 0.082498 | 1.084 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.082498 | 1.084 |
| R-HSA-170984 | ARMS-mediated activation | 0.089654 | 1.047 |
| R-HSA-4839744 | Signaling by APC mutants | 0.103801 | 0.984 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.103801 | 0.984 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.103801 | 0.984 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.103801 | 0.984 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.110792 | 0.955 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.110792 | 0.955 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.117729 | 0.929 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.117729 | 0.929 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.117729 | 0.929 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.117729 | 0.929 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.117729 | 0.929 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.138220 | 0.859 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.171328 | 0.766 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.171328 | 0.766 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.177797 | 0.750 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.177797 | 0.750 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.177797 | 0.750 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.177797 | 0.750 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.069598 | 1.157 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.080802 | 1.093 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.107178 | 0.970 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.107178 | 0.970 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.114727 | 0.940 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.132838 | 0.877 |
| R-HSA-380287 | Centrosome maturation | 0.138127 | 0.860 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.086966 | 1.061 |
| R-HSA-72172 | mRNA Splicing | 0.099868 | 1.001 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.181872 | 0.740 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.083106 | 1.080 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.082498 | 1.084 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.151618 | 0.819 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.177797 | 0.750 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.154258 | 0.812 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.090137 | 1.045 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.124613 | 0.904 |
| R-HSA-5693538 | Homology Directed Repair | 0.085684 | 1.067 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.089654 | 1.047 |
| R-HSA-167172 | Transcription of the HIV genome | 0.119834 | 0.921 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.135477 | 0.868 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.110792 | 0.955 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.110792 | 0.955 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.124613 | 0.904 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.138220 | 0.859 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.164809 | 0.783 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.164809 | 0.783 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.190584 | 0.720 |
| R-HSA-5620924 | Intraflagellar transport | 0.071795 | 1.144 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.164809 | 0.783 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.075286 | 1.123 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.164809 | 0.783 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.150894 | 0.821 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.096755 | 1.014 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.196903 | 0.706 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.097336 | 1.012 |
| R-HSA-391251 | Protein folding | 0.190297 | 0.721 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.131125 | 0.882 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.075286 | 1.123 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.138220 | 0.859 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.171328 | 0.766 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.184215 | 0.735 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.162456 | 0.789 |
| R-HSA-169893 | Prolonged ERK activation events | 0.144945 | 0.839 |
| R-HSA-9664873 | Pexophagy | 0.096755 | 1.014 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.071795 | 1.144 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.138220 | 0.859 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.104693 | 0.980 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.117274 | 0.931 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.087774 | 1.057 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.119834 | 0.921 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.075286 | 1.123 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.110792 | 0.955 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.124613 | 0.904 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.171328 | 0.766 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.135477 | 0.868 |
| R-HSA-5578775 | Ion homeostasis | 0.090137 | 1.045 |
| R-HSA-162587 | HIV Life Cycle | 0.158308 | 0.800 |
| R-HSA-8953854 | Metabolism of RNA | 0.134381 | 0.872 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.173506 | 0.761 |
| R-HSA-69481 | G2/M Checkpoints | 0.101025 | 0.996 |
| R-HSA-162906 | HIV Infection | 0.129493 | 0.888 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.103801 | 0.984 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.131443 | 0.881 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.131443 | 0.881 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.158239 | 0.801 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.203174 | 0.692 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.203174 | 0.692 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.164809 | 0.783 |
| R-HSA-109704 | PI3K Cascade | 0.076255 | 1.118 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.204452 | 0.689 |
| R-HSA-373753 | Nephrin family interactions | 0.177797 | 0.750 |
| R-HSA-9659379 | Sensory processing of sound | 0.148840 | 0.827 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.165206 | 0.782 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.203174 | 0.692 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.089654 | 1.047 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.117729 | 0.929 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.090137 | 1.045 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.139993 | 0.854 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.117729 | 0.929 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.074014 | 1.131 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.138127 | 0.860 |
| R-HSA-199991 | Membrane Trafficking | 0.154693 | 0.811 |
| R-HSA-112399 | IRS-mediated signalling | 0.092518 | 1.034 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.082498 | 1.084 |
| R-HSA-2028269 | Signaling by Hippo | 0.158239 | 0.801 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.124996 | 0.903 |
| R-HSA-445144 | Signal transduction by L1 | 0.177797 | 0.750 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.102224 | 0.990 |
| R-HSA-983712 | Ion channel transport | 0.081389 | 1.089 |
| R-HSA-162582 | Signal Transduction | 0.145919 | 0.836 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.196903 | 0.706 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.127598 | 0.894 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.171328 | 0.766 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.132838 | 0.877 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.146146 | 0.835 |
| R-HSA-449836 | Other interleukin signaling | 0.171328 | 0.766 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.109679 | 0.960 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.109679 | 0.960 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.132838 | 0.877 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.112196 | 0.950 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.119834 | 0.921 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.151544 | 0.819 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.109679 | 0.960 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.194936 | 0.710 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.164809 | 0.783 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.190297 | 0.721 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.196903 | 0.706 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.112196 | 0.950 |
| R-HSA-73887 | Death Receptor Signaling | 0.152737 | 0.816 |
| R-HSA-9833482 | PKR-mediated signaling | 0.151544 | 0.819 |
| R-HSA-109582 | Hemostasis | 0.100529 | 0.998 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.182111 | 0.740 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.140789 | 0.851 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.080802 | 1.093 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.096162 | 1.017 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.103191 | 0.986 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.173506 | 0.761 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.161545 | 0.792 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.209396 | 0.679 |
| R-HSA-429947 | Deadenylation of mRNA | 0.209396 | 0.679 |
| R-HSA-190236 | Signaling by FGFR | 0.210147 | 0.677 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.213001 | 0.672 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.215569 | 0.666 |
| R-HSA-420029 | Tight junction interactions | 0.215569 | 0.666 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.215859 | 0.666 |
| R-HSA-69275 | G2/M Transition | 0.217026 | 0.663 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.221099 | 0.655 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.221585 | 0.654 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.221695 | 0.654 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.221695 | 0.654 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.221695 | 0.654 |
| R-HSA-70635 | Urea cycle | 0.221695 | 0.654 |
| R-HSA-5617833 | Cilium Assembly | 0.225188 | 0.647 |
| R-HSA-8949613 | Cristae formation | 0.227774 | 0.642 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.227774 | 0.642 |
| R-HSA-264876 | Insulin processing | 0.227774 | 0.642 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.233782 | 0.631 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.233805 | 0.631 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.233805 | 0.631 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.235950 | 0.627 |
| R-HSA-418346 | Platelet homeostasis | 0.235950 | 0.627 |
| R-HSA-9609690 | HCMV Early Events | 0.237542 | 0.624 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.239790 | 0.620 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.239790 | 0.620 |
| R-HSA-72086 | mRNA Capping | 0.239790 | 0.620 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.241713 | 0.617 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.245728 | 0.610 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.245728 | 0.610 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.245728 | 0.610 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.250013 | 0.602 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.251620 | 0.599 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.251620 | 0.599 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.251620 | 0.599 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.251620 | 0.599 |
| R-HSA-182971 | EGFR downregulation | 0.251620 | 0.599 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.257466 | 0.589 |
| R-HSA-5357801 | Programmed Cell Death | 0.258382 | 0.588 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.259033 | 0.587 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.263268 | 0.580 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.263268 | 0.580 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.263268 | 0.580 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.263268 | 0.580 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.263268 | 0.580 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.263268 | 0.580 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.263268 | 0.580 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.263268 | 0.580 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.269024 | 0.570 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.269024 | 0.570 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.269024 | 0.570 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.269024 | 0.570 |
| R-HSA-1500931 | Cell-Cell communication | 0.269470 | 0.569 |
| R-HSA-397014 | Muscle contraction | 0.273117 | 0.564 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.274736 | 0.561 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.274736 | 0.561 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.274736 | 0.561 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.274736 | 0.561 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.276383 | 0.558 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.280403 | 0.552 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.280403 | 0.552 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.280403 | 0.552 |
| R-HSA-187687 | Signalling to ERKs | 0.280403 | 0.552 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.281587 | 0.550 |
| R-HSA-68875 | Mitotic Prophase | 0.282149 | 0.550 |
| R-HSA-422475 | Axon guidance | 0.283181 | 0.548 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.286026 | 0.544 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.291606 | 0.535 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.291606 | 0.535 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.291606 | 0.535 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.293692 | 0.532 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.297143 | 0.527 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.297143 | 0.527 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.297143 | 0.527 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.297143 | 0.527 |
| R-HSA-69206 | G1/S Transition | 0.299454 | 0.524 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.302636 | 0.519 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.302636 | 0.519 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.302636 | 0.519 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.307095 | 0.513 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.308087 | 0.511 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.308087 | 0.511 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.308087 | 0.511 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.313496 | 0.504 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.313496 | 0.504 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.313496 | 0.504 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.313496 | 0.504 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.313496 | 0.504 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.314868 | 0.502 |
| R-HSA-5576891 | Cardiac conduction | 0.319560 | 0.495 |
| R-HSA-9909396 | Circadian clock | 0.322423 | 0.492 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.323242 | 0.490 |
| R-HSA-9675108 | Nervous system development | 0.333769 | 0.477 |
| R-HSA-5683826 | Surfactant metabolism | 0.334715 | 0.475 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.336688 | 0.473 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.339917 | 0.469 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.339917 | 0.469 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.342370 | 0.466 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.345079 | 0.462 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.345079 | 0.462 |
| R-HSA-9675135 | Diseases of DNA repair | 0.345079 | 0.462 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.345079 | 0.462 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.345079 | 0.462 |
| R-HSA-4839726 | Chromatin organization | 0.351905 | 0.454 |
| R-HSA-9609646 | HCMV Infection | 0.354035 | 0.451 |
| R-HSA-912446 | Meiotic recombination | 0.370293 | 0.431 |
| R-HSA-1266738 | Developmental Biology | 0.370509 | 0.431 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.375219 | 0.426 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.375219 | 0.426 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.375219 | 0.426 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.380107 | 0.420 |
| R-HSA-1221632 | Meiotic synapsis | 0.380107 | 0.420 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.380107 | 0.420 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.381677 | 0.418 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.384449 | 0.415 |
| R-HSA-69306 | DNA Replication | 0.387216 | 0.412 |
| R-HSA-913531 | Interferon Signaling | 0.389270 | 0.410 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.392733 | 0.406 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.394544 | 0.404 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.394544 | 0.404 |
| R-HSA-75893 | TNF signaling | 0.394544 | 0.404 |
| R-HSA-177929 | Signaling by EGFR | 0.394544 | 0.404 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.399282 | 0.399 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.399282 | 0.399 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.403983 | 0.394 |
| R-HSA-191859 | snRNP Assembly | 0.408648 | 0.389 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.408648 | 0.389 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.408648 | 0.389 |
| R-HSA-9824446 | Viral Infection Pathways | 0.410163 | 0.387 |
| R-HSA-109581 | Apoptosis | 0.411865 | 0.385 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.413276 | 0.384 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.417869 | 0.379 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.417869 | 0.379 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.422426 | 0.374 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.422426 | 0.374 |
| R-HSA-9707616 | Heme signaling | 0.422426 | 0.374 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.422426 | 0.374 |
| R-HSA-186797 | Signaling by PDGF | 0.422426 | 0.374 |
| R-HSA-5619102 | SLC transporter disorders | 0.425351 | 0.371 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.440302 | 0.356 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.444684 | 0.352 |
| R-HSA-5218859 | Regulated Necrosis | 0.449033 | 0.348 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.449033 | 0.348 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.457628 | 0.339 |
| R-HSA-168255 | Influenza Infection | 0.459647 | 0.338 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.461876 | 0.335 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.466091 | 0.332 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.466091 | 0.332 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.470273 | 0.328 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.470273 | 0.328 |
| R-HSA-1643685 | Disease | 0.474295 | 0.324 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.478541 | 0.320 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.488953 | 0.311 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.490702 | 0.309 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.506480 | 0.295 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.514186 | 0.289 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.514186 | 0.289 |
| R-HSA-1500620 | Meiosis | 0.517995 | 0.286 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.519743 | 0.284 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.521773 | 0.283 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.525523 | 0.279 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.525523 | 0.279 |
| R-HSA-156902 | Peptide chain elongation | 0.532934 | 0.273 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.532934 | 0.273 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.540230 | 0.267 |
| R-HSA-73884 | Base Excision Repair | 0.540230 | 0.267 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.543836 | 0.265 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.547413 | 0.262 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.550963 | 0.259 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.553480 | 0.257 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.554485 | 0.256 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.561448 | 0.251 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.561448 | 0.251 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.564888 | 0.248 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.564888 | 0.248 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.564888 | 0.248 |
| R-HSA-449147 | Signaling by Interleukins | 0.572808 | 0.242 |
| R-HSA-73894 | DNA Repair | 0.573443 | 0.242 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.575050 | 0.240 |
| R-HSA-422356 | Regulation of insulin secretion | 0.575050 | 0.240 |
| R-HSA-70171 | Glycolysis | 0.581694 | 0.235 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.584977 | 0.233 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.588234 | 0.230 |
| R-HSA-192823 | Viral mRNA Translation | 0.591466 | 0.228 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.591466 | 0.228 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.594673 | 0.226 |
| R-HSA-8939211 | ESR-mediated signaling | 0.599133 | 0.222 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.601012 | 0.221 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.601012 | 0.221 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.607253 | 0.217 |
| R-HSA-69239 | Synthesis of DNA | 0.607253 | 0.217 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.607253 | 0.217 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.607253 | 0.217 |
| R-HSA-211000 | Gene Silencing by RNA | 0.607253 | 0.217 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.610336 | 0.214 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.610336 | 0.214 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.613396 | 0.212 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.616432 | 0.210 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.616432 | 0.210 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.619948 | 0.208 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.622434 | 0.206 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.622434 | 0.206 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.622434 | 0.206 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.631261 | 0.200 |
| R-HSA-5688426 | Deubiquitination | 0.636000 | 0.197 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.639884 | 0.194 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.639884 | 0.194 |
| R-HSA-70326 | Glucose metabolism | 0.642714 | 0.192 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.642714 | 0.192 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.642714 | 0.192 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.642714 | 0.192 |
| R-HSA-3371556 | Cellular response to heat stress | 0.653814 | 0.185 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.653814 | 0.185 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.659234 | 0.181 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.660956 | 0.180 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.661913 | 0.179 |
| R-HSA-9679506 | SARS-CoV Infections | 0.663505 | 0.178 |
| R-HSA-114608 | Platelet degranulation | 0.672421 | 0.172 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.674997 | 0.171 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.676713 | 0.170 |
| R-HSA-446728 | Cell junction organization | 0.679214 | 0.168 |
| R-HSA-1474165 | Reproduction | 0.682604 | 0.166 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.690035 | 0.161 |
| R-HSA-5663205 | Infectious disease | 0.698629 | 0.156 |
| R-HSA-163685 | Integration of energy metabolism | 0.699676 | 0.155 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.704383 | 0.152 |
| R-HSA-5368287 | Mitochondrial translation | 0.704383 | 0.152 |
| R-HSA-2262752 | Cellular responses to stress | 0.710627 | 0.148 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.715835 | 0.145 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.718072 | 0.144 |
| R-HSA-69242 | S Phase | 0.728998 | 0.137 |
| R-HSA-166520 | Signaling by NTRKs | 0.728998 | 0.137 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.728998 | 0.137 |
| R-HSA-9758941 | Gastrulation | 0.731132 | 0.136 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.737435 | 0.132 |
| R-HSA-9609507 | Protein localization | 0.739504 | 0.131 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.741556 | 0.130 |
| R-HSA-9610379 | HCMV Late Events | 0.747616 | 0.126 |
| R-HSA-9711097 | Cellular response to starvation | 0.749605 | 0.125 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.753536 | 0.123 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.761215 | 0.118 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.774086 | 0.111 |
| R-HSA-72306 | tRNA processing | 0.774086 | 0.111 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.777636 | 0.109 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.796191 | 0.099 |
| R-HSA-382551 | Transport of small molecules | 0.802511 | 0.096 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.803961 | 0.095 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.804109 | 0.095 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.808713 | 0.092 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.814430 | 0.089 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.821890 | 0.085 |
| R-HSA-6805567 | Keratinization | 0.831512 | 0.080 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.834540 | 0.079 |
| R-HSA-8951664 | Neddylation | 0.850430 | 0.070 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.856255 | 0.067 |
| R-HSA-72312 | rRNA processing | 0.862948 | 0.064 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.865110 | 0.063 |
| R-HSA-74160 | Gene expression (Transcription) | 0.866972 | 0.062 |
| R-HSA-72766 | Translation | 0.870013 | 0.060 |
| R-HSA-421270 | Cell-cell junction organization | 0.882171 | 0.054 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.886768 | 0.052 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.901893 | 0.045 |
| R-HSA-597592 | Post-translational protein modification | 0.918537 | 0.037 |
| R-HSA-195721 | Signaling by WNT | 0.918986 | 0.037 |
| R-HSA-1280218 | Adaptive Immune System | 0.925631 | 0.034 |
| R-HSA-212436 | Generic Transcription Pathway | 0.933167 | 0.030 |
| R-HSA-1474244 | Extracellular matrix organization | 0.937764 | 0.028 |
| R-HSA-392499 | Metabolism of proteins | 0.953493 | 0.021 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.962230 | 0.017 |
| R-HSA-168256 | Immune System | 0.963531 | 0.016 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.963626 | 0.016 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.964506 | 0.016 |
| R-HSA-5668914 | Diseases of metabolism | 0.971422 | 0.013 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.977193 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 0.987205 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 0.992932 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.998731 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999587 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.859 | 0.323 | 1 | 0.832 |
PRKD1 |
0.851 | 0.285 | -3 | 0.838 |
PIM3 |
0.846 | 0.217 | -3 | 0.849 |
NDR2 |
0.846 | 0.176 | -3 | 0.838 |
PRKD2 |
0.845 | 0.251 | -3 | 0.818 |
COT |
0.845 | 0.096 | 2 | 0.830 |
CDC7 |
0.844 | 0.110 | 1 | 0.832 |
RSK2 |
0.844 | 0.252 | -3 | 0.816 |
HIPK4 |
0.843 | 0.248 | 1 | 0.762 |
MOS |
0.841 | 0.166 | 1 | 0.858 |
PIM1 |
0.840 | 0.249 | -3 | 0.825 |
MAPKAPK2 |
0.840 | 0.237 | -3 | 0.793 |
SRPK1 |
0.838 | 0.218 | -3 | 0.793 |
CDKL1 |
0.838 | 0.204 | -3 | 0.825 |
CAMK1B |
0.838 | 0.179 | -3 | 0.859 |
CDKL5 |
0.837 | 0.212 | -3 | 0.827 |
SKMLCK |
0.836 | 0.198 | -2 | 0.863 |
ICK |
0.836 | 0.238 | -3 | 0.845 |
GRK1 |
0.836 | 0.155 | -2 | 0.732 |
CAMK2B |
0.835 | 0.231 | 2 | 0.802 |
PKN3 |
0.835 | 0.149 | -3 | 0.837 |
P90RSK |
0.835 | 0.204 | -3 | 0.810 |
AURC |
0.834 | 0.179 | -2 | 0.698 |
MTOR |
0.834 | -0.004 | 1 | 0.753 |
PRKX |
0.834 | 0.259 | -3 | 0.752 |
PRPK |
0.833 | -0.041 | -1 | 0.867 |
IKKB |
0.833 | -0.008 | -2 | 0.657 |
CAMK2D |
0.833 | 0.168 | -3 | 0.838 |
CLK2 |
0.833 | 0.270 | -3 | 0.803 |
MAPKAPK3 |
0.832 | 0.168 | -3 | 0.816 |
RSK4 |
0.832 | 0.243 | -3 | 0.792 |
LATS2 |
0.831 | 0.116 | -5 | 0.656 |
PKACG |
0.831 | 0.164 | -2 | 0.754 |
NDR1 |
0.831 | 0.111 | -3 | 0.844 |
CAMK2A |
0.831 | 0.208 | 2 | 0.791 |
RSK3 |
0.831 | 0.181 | -3 | 0.808 |
PKACB |
0.831 | 0.223 | -2 | 0.704 |
TSSK1 |
0.830 | 0.190 | -3 | 0.875 |
DYRK2 |
0.830 | 0.187 | 1 | 0.715 |
ATR |
0.830 | 0.049 | 1 | 0.789 |
CAMK2G |
0.829 | 0.021 | 2 | 0.809 |
TSSK2 |
0.829 | 0.172 | -5 | 0.824 |
CAMLCK |
0.829 | 0.149 | -2 | 0.820 |
NLK |
0.829 | 0.036 | 1 | 0.820 |
HIPK2 |
0.828 | 0.214 | 1 | 0.627 |
P70S6KB |
0.828 | 0.155 | -3 | 0.827 |
IKKA |
0.828 | 0.067 | -2 | 0.651 |
SRPK2 |
0.827 | 0.188 | -3 | 0.737 |
CLK4 |
0.827 | 0.212 | -3 | 0.806 |
NUAK2 |
0.827 | 0.095 | -3 | 0.858 |
WNK1 |
0.827 | 0.061 | -2 | 0.866 |
RAF1 |
0.827 | -0.086 | 1 | 0.795 |
AMPKA1 |
0.827 | 0.112 | -3 | 0.861 |
MSK1 |
0.827 | 0.203 | -3 | 0.795 |
ERK5 |
0.827 | 0.053 | 1 | 0.812 |
DAPK2 |
0.827 | 0.150 | -3 | 0.851 |
FAM20C |
0.826 | 0.240 | 2 | 0.727 |
PDHK4 |
0.826 | -0.168 | 1 | 0.813 |
TBK1 |
0.826 | -0.070 | 1 | 0.701 |
CLK1 |
0.825 | 0.213 | -3 | 0.794 |
KIS |
0.825 | 0.081 | 1 | 0.713 |
GRK5 |
0.825 | -0.034 | -3 | 0.785 |
NIK |
0.824 | 0.060 | -3 | 0.852 |
PRKD3 |
0.824 | 0.190 | -3 | 0.786 |
HIPK1 |
0.824 | 0.213 | 1 | 0.727 |
BMPR2 |
0.824 | -0.133 | -2 | 0.801 |
MSK2 |
0.824 | 0.154 | -3 | 0.779 |
CHAK2 |
0.824 | 0.011 | -1 | 0.868 |
AMPKA2 |
0.824 | 0.126 | -3 | 0.847 |
PKCD |
0.823 | 0.108 | 2 | 0.747 |
PKN2 |
0.823 | 0.073 | -3 | 0.843 |
BMPR1B |
0.823 | 0.171 | 1 | 0.784 |
GRK7 |
0.823 | 0.181 | 1 | 0.751 |
CDK8 |
0.823 | 0.094 | 1 | 0.680 |
DSTYK |
0.823 | -0.038 | 2 | 0.860 |
LATS1 |
0.823 | 0.199 | -3 | 0.833 |
MARK4 |
0.823 | 0.036 | 4 | 0.747 |
MST4 |
0.822 | 0.021 | 2 | 0.820 |
GRK6 |
0.821 | 0.056 | 1 | 0.822 |
SRPK3 |
0.821 | 0.152 | -3 | 0.760 |
IKKE |
0.821 | -0.102 | 1 | 0.693 |
PAK1 |
0.820 | 0.101 | -2 | 0.787 |
GCN2 |
0.820 | -0.203 | 2 | 0.779 |
SGK3 |
0.819 | 0.194 | -3 | 0.809 |
AURB |
0.819 | 0.135 | -2 | 0.685 |
TGFBR2 |
0.819 | -0.033 | -2 | 0.730 |
TGFBR1 |
0.819 | 0.136 | -2 | 0.767 |
AKT2 |
0.819 | 0.198 | -3 | 0.756 |
CDK19 |
0.818 | 0.093 | 1 | 0.646 |
PDHK1 |
0.818 | -0.190 | 1 | 0.803 |
NEK6 |
0.818 | -0.063 | -2 | 0.773 |
DYRK1A |
0.817 | 0.194 | 1 | 0.736 |
MNK2 |
0.817 | 0.093 | -2 | 0.796 |
RIPK3 |
0.817 | -0.086 | 3 | 0.698 |
CAMK4 |
0.817 | 0.052 | -3 | 0.834 |
PKG2 |
0.817 | 0.149 | -2 | 0.706 |
ULK2 |
0.817 | -0.195 | 2 | 0.762 |
PKACA |
0.816 | 0.200 | -2 | 0.666 |
ALK4 |
0.816 | 0.089 | -2 | 0.786 |
PAK6 |
0.815 | 0.132 | -2 | 0.689 |
AURA |
0.815 | 0.127 | -2 | 0.656 |
CDK7 |
0.815 | 0.069 | 1 | 0.687 |
QSK |
0.815 | 0.075 | 4 | 0.716 |
CHK1 |
0.815 | 0.139 | -3 | 0.851 |
BCKDK |
0.814 | -0.134 | -1 | 0.806 |
CDK1 |
0.814 | 0.097 | 1 | 0.657 |
MLK1 |
0.814 | -0.126 | 2 | 0.772 |
ATM |
0.814 | 0.015 | 1 | 0.727 |
MNK1 |
0.814 | 0.101 | -2 | 0.795 |
MASTL |
0.814 | -0.162 | -2 | 0.738 |
CDK18 |
0.813 | 0.110 | 1 | 0.629 |
DYRK4 |
0.813 | 0.159 | 1 | 0.649 |
PIM2 |
0.813 | 0.175 | -3 | 0.800 |
PAK3 |
0.813 | 0.041 | -2 | 0.772 |
JNK2 |
0.813 | 0.123 | 1 | 0.642 |
GRK4 |
0.813 | -0.075 | -2 | 0.750 |
DYRK1B |
0.813 | 0.162 | 1 | 0.677 |
HUNK |
0.812 | -0.134 | 2 | 0.764 |
PKCB |
0.812 | 0.063 | 2 | 0.695 |
NUAK1 |
0.812 | 0.060 | -3 | 0.822 |
MYLK4 |
0.812 | 0.111 | -2 | 0.769 |
CDK5 |
0.811 | 0.095 | 1 | 0.703 |
MAK |
0.811 | 0.273 | -2 | 0.788 |
MELK |
0.811 | 0.058 | -3 | 0.833 |
JNK3 |
0.811 | 0.106 | 1 | 0.676 |
WNK3 |
0.811 | -0.193 | 1 | 0.759 |
DYRK3 |
0.811 | 0.189 | 1 | 0.728 |
HIPK3 |
0.810 | 0.160 | 1 | 0.719 |
NEK7 |
0.810 | -0.190 | -3 | 0.742 |
PKCA |
0.810 | 0.052 | 2 | 0.688 |
ALK2 |
0.810 | 0.113 | -2 | 0.761 |
SIK |
0.810 | 0.077 | -3 | 0.792 |
PKCG |
0.810 | 0.034 | 2 | 0.683 |
DLK |
0.809 | -0.140 | 1 | 0.792 |
NIM1 |
0.809 | -0.047 | 3 | 0.745 |
P38A |
0.809 | 0.101 | 1 | 0.718 |
P38B |
0.808 | 0.117 | 1 | 0.670 |
AKT1 |
0.808 | 0.183 | -3 | 0.772 |
CDK13 |
0.808 | 0.044 | 1 | 0.663 |
PAK2 |
0.808 | 0.041 | -2 | 0.763 |
PHKG1 |
0.807 | 0.010 | -3 | 0.834 |
MLK2 |
0.807 | -0.113 | 2 | 0.796 |
ERK1 |
0.807 | 0.087 | 1 | 0.651 |
BRSK1 |
0.807 | 0.047 | -3 | 0.817 |
DCAMKL1 |
0.807 | 0.124 | -3 | 0.820 |
RIPK1 |
0.807 | -0.160 | 1 | 0.765 |
PKCZ |
0.806 | 0.018 | 2 | 0.745 |
DNAPK |
0.806 | 0.042 | 1 | 0.650 |
ANKRD3 |
0.806 | -0.160 | 1 | 0.817 |
PKR |
0.806 | -0.020 | 1 | 0.799 |
ACVR2A |
0.805 | 0.030 | -2 | 0.704 |
BMPR1A |
0.805 | 0.132 | 1 | 0.768 |
MLK3 |
0.805 | -0.064 | 2 | 0.700 |
ACVR2B |
0.805 | 0.044 | -2 | 0.715 |
PASK |
0.805 | 0.151 | -3 | 0.841 |
P38G |
0.805 | 0.095 | 1 | 0.575 |
QIK |
0.805 | -0.042 | -3 | 0.825 |
PKCH |
0.805 | 0.022 | 2 | 0.680 |
CAMK1G |
0.805 | 0.087 | -3 | 0.796 |
CAMK1D |
0.805 | 0.176 | -3 | 0.748 |
IRE1 |
0.804 | -0.111 | 1 | 0.738 |
TTBK2 |
0.804 | -0.164 | 2 | 0.679 |
ULK1 |
0.804 | -0.237 | -3 | 0.731 |
MARK3 |
0.804 | 0.017 | 4 | 0.664 |
CDK12 |
0.803 | 0.054 | 1 | 0.639 |
VRK2 |
0.803 | -0.117 | 1 | 0.842 |
CDK17 |
0.803 | 0.071 | 1 | 0.584 |
MAPKAPK5 |
0.803 | 0.029 | -3 | 0.758 |
CK2A2 |
0.803 | 0.229 | 1 | 0.731 |
CDK3 |
0.802 | 0.095 | 1 | 0.603 |
SGK1 |
0.802 | 0.214 | -3 | 0.699 |
NEK9 |
0.802 | -0.218 | 2 | 0.809 |
PLK1 |
0.802 | -0.090 | -2 | 0.687 |
MARK2 |
0.801 | -0.001 | 4 | 0.629 |
IRE2 |
0.801 | -0.076 | 2 | 0.714 |
TLK2 |
0.801 | -0.035 | 1 | 0.728 |
CDK9 |
0.801 | 0.031 | 1 | 0.671 |
SSTK |
0.801 | 0.055 | 4 | 0.710 |
MEK1 |
0.800 | -0.156 | 2 | 0.812 |
MPSK1 |
0.800 | 0.122 | 1 | 0.740 |
BRSK2 |
0.800 | -0.024 | -3 | 0.827 |
SMMLCK |
0.800 | 0.102 | -3 | 0.832 |
GSK3A |
0.800 | 0.067 | 4 | 0.430 |
GRK2 |
0.799 | -0.034 | -2 | 0.670 |
CDK14 |
0.799 | 0.084 | 1 | 0.670 |
P70S6K |
0.799 | 0.107 | -3 | 0.764 |
MOK |
0.799 | 0.230 | 1 | 0.738 |
DAPK3 |
0.799 | 0.167 | -3 | 0.823 |
AKT3 |
0.798 | 0.188 | -3 | 0.709 |
MLK4 |
0.798 | -0.093 | 2 | 0.689 |
SMG1 |
0.798 | -0.077 | 1 | 0.733 |
CDK10 |
0.797 | 0.100 | 1 | 0.658 |
CK1E |
0.797 | -0.020 | -3 | 0.473 |
CHAK1 |
0.797 | -0.147 | 2 | 0.752 |
PLK3 |
0.797 | -0.052 | 2 | 0.749 |
WNK4 |
0.796 | -0.026 | -2 | 0.849 |
ERK2 |
0.796 | 0.019 | 1 | 0.682 |
MARK1 |
0.796 | -0.022 | 4 | 0.687 |
PRP4 |
0.796 | 0.020 | -3 | 0.683 |
SBK |
0.795 | 0.204 | -3 | 0.669 |
P38D |
0.795 | 0.106 | 1 | 0.590 |
PKCT |
0.795 | 0.039 | 2 | 0.695 |
YSK4 |
0.795 | -0.166 | 1 | 0.716 |
DCAMKL2 |
0.795 | 0.038 | -3 | 0.834 |
NEK2 |
0.795 | -0.140 | 2 | 0.786 |
PAK5 |
0.794 | 0.079 | -2 | 0.651 |
BRAF |
0.794 | -0.067 | -4 | 0.802 |
DAPK1 |
0.794 | 0.152 | -3 | 0.810 |
CDK2 |
0.793 | -0.025 | 1 | 0.735 |
DRAK1 |
0.793 | -0.073 | 1 | 0.736 |
CDK16 |
0.793 | 0.073 | 1 | 0.600 |
PAK4 |
0.793 | 0.090 | -2 | 0.661 |
GSK3B |
0.793 | 0.002 | 4 | 0.421 |
SNRK |
0.791 | -0.152 | 2 | 0.657 |
GAK |
0.791 | 0.083 | 1 | 0.820 |
CHK2 |
0.791 | 0.146 | -3 | 0.716 |
CAMK1A |
0.791 | 0.158 | -3 | 0.726 |
CK2A1 |
0.791 | 0.190 | 1 | 0.708 |
TAO3 |
0.791 | -0.030 | 1 | 0.746 |
MST3 |
0.790 | -0.042 | 2 | 0.788 |
PKCE |
0.789 | 0.075 | 2 | 0.670 |
MEKK1 |
0.789 | -0.165 | 1 | 0.773 |
GRK3 |
0.789 | -0.021 | -2 | 0.639 |
ROCK2 |
0.788 | 0.170 | -3 | 0.823 |
PHKG2 |
0.788 | -0.015 | -3 | 0.823 |
CK1D |
0.788 | -0.023 | -3 | 0.421 |
MEK5 |
0.788 | -0.251 | 2 | 0.797 |
BUB1 |
0.788 | 0.146 | -5 | 0.807 |
PKN1 |
0.787 | 0.090 | -3 | 0.778 |
PERK |
0.787 | -0.187 | -2 | 0.730 |
MEKK2 |
0.787 | -0.135 | 2 | 0.777 |
PDK1 |
0.787 | 0.000 | 1 | 0.762 |
MRCKA |
0.786 | 0.134 | -3 | 0.795 |
MRCKB |
0.786 | 0.144 | -3 | 0.788 |
MEKK3 |
0.786 | -0.196 | 1 | 0.758 |
ZAK |
0.786 | -0.166 | 1 | 0.739 |
JNK1 |
0.786 | 0.057 | 1 | 0.638 |
PKCI |
0.786 | -0.003 | 2 | 0.704 |
IRAK4 |
0.786 | -0.134 | 1 | 0.749 |
NEK5 |
0.786 | -0.142 | 1 | 0.778 |
PLK4 |
0.785 | -0.150 | 2 | 0.604 |
PINK1 |
0.785 | -0.176 | 1 | 0.786 |
TLK1 |
0.785 | -0.132 | -2 | 0.762 |
CK1A2 |
0.784 | -0.035 | -3 | 0.428 |
HRI |
0.783 | -0.247 | -2 | 0.753 |
DMPK1 |
0.782 | 0.187 | -3 | 0.806 |
CK1G1 |
0.780 | -0.079 | -3 | 0.443 |
CDK4 |
0.779 | 0.048 | 1 | 0.628 |
GCK |
0.779 | -0.050 | 1 | 0.746 |
TAO2 |
0.779 | -0.122 | 2 | 0.815 |
CRIK |
0.779 | 0.177 | -3 | 0.775 |
PKG1 |
0.779 | 0.109 | -2 | 0.640 |
ERK7 |
0.779 | -0.001 | 2 | 0.508 |
PLK2 |
0.778 | 0.017 | -3 | 0.727 |
TNIK |
0.778 | -0.013 | 3 | 0.805 |
EEF2K |
0.778 | -0.055 | 3 | 0.784 |
NEK11 |
0.777 | -0.211 | 1 | 0.749 |
CDK6 |
0.777 | 0.028 | 1 | 0.647 |
CAMKK2 |
0.776 | -0.176 | -2 | 0.657 |
LKB1 |
0.776 | -0.129 | -3 | 0.754 |
LRRK2 |
0.775 | -0.116 | 2 | 0.813 |
NEK8 |
0.775 | -0.205 | 2 | 0.777 |
IRAK1 |
0.775 | -0.254 | -1 | 0.763 |
PDHK3_TYR |
0.774 | 0.250 | 4 | 0.840 |
CAMKK1 |
0.774 | -0.237 | -2 | 0.645 |
KHS1 |
0.774 | -0.001 | 1 | 0.728 |
MAP3K15 |
0.774 | -0.111 | 1 | 0.714 |
HPK1 |
0.774 | -0.060 | 1 | 0.734 |
HGK |
0.773 | -0.088 | 3 | 0.804 |
MINK |
0.773 | -0.093 | 1 | 0.737 |
MST2 |
0.772 | -0.132 | 1 | 0.766 |
MEKK6 |
0.772 | -0.137 | 1 | 0.734 |
PBK |
0.772 | 0.045 | 1 | 0.751 |
ROCK1 |
0.772 | 0.129 | -3 | 0.800 |
TTBK1 |
0.772 | -0.215 | 2 | 0.590 |
KHS2 |
0.771 | -0.001 | 1 | 0.737 |
TAK1 |
0.771 | -0.151 | 1 | 0.753 |
VRK1 |
0.770 | -0.139 | 2 | 0.792 |
LOK |
0.769 | -0.094 | -2 | 0.710 |
NEK4 |
0.768 | -0.221 | 1 | 0.738 |
HASPIN |
0.766 | 0.023 | -1 | 0.719 |
NEK1 |
0.766 | -0.158 | 1 | 0.751 |
SLK |
0.765 | -0.109 | -2 | 0.661 |
MAP2K4_TYR |
0.765 | 0.087 | -1 | 0.890 |
PDHK4_TYR |
0.763 | 0.061 | 2 | 0.852 |
YSK1 |
0.763 | -0.115 | 2 | 0.780 |
MST1 |
0.762 | -0.174 | 1 | 0.744 |
TESK1_TYR |
0.762 | -0.022 | 3 | 0.844 |
MAP2K6_TYR |
0.762 | 0.049 | -1 | 0.896 |
BIKE |
0.761 | 0.055 | 1 | 0.718 |
PDHK1_TYR |
0.761 | 0.060 | -1 | 0.905 |
PKMYT1_TYR |
0.760 | -0.002 | 3 | 0.803 |
OSR1 |
0.760 | -0.082 | 2 | 0.771 |
LIMK2_TYR |
0.759 | 0.065 | -3 | 0.848 |
TTK |
0.758 | -0.087 | -2 | 0.731 |
MEK2 |
0.758 | -0.280 | 2 | 0.794 |
MAP2K7_TYR |
0.758 | -0.119 | 2 | 0.836 |
BMPR2_TYR |
0.757 | -0.003 | -1 | 0.875 |
YANK3 |
0.757 | -0.065 | 2 | 0.368 |
STK33 |
0.757 | -0.213 | 2 | 0.574 |
RIPK2 |
0.756 | -0.288 | 1 | 0.700 |
ALPHAK3 |
0.755 | -0.041 | -1 | 0.794 |
PINK1_TYR |
0.755 | -0.116 | 1 | 0.798 |
CK1A |
0.753 | -0.050 | -3 | 0.329 |
MYO3B |
0.752 | -0.092 | 2 | 0.795 |
ASK1 |
0.751 | -0.153 | 1 | 0.706 |
AAK1 |
0.750 | 0.107 | 1 | 0.622 |
RET |
0.750 | -0.090 | 1 | 0.760 |
NEK3 |
0.750 | -0.215 | 1 | 0.709 |
EPHA6 |
0.749 | -0.015 | -1 | 0.851 |
EPHB4 |
0.749 | -0.035 | -1 | 0.832 |
LIMK1_TYR |
0.748 | -0.136 | 2 | 0.832 |
TXK |
0.747 | 0.043 | 1 | 0.833 |
ROS1 |
0.746 | -0.101 | 3 | 0.713 |
TAO1 |
0.746 | -0.144 | 1 | 0.670 |
FGR |
0.746 | -0.023 | 1 | 0.833 |
ABL2 |
0.745 | -0.018 | -1 | 0.807 |
FER |
0.745 | -0.069 | 1 | 0.854 |
DDR1 |
0.745 | -0.112 | 4 | 0.772 |
MYO3A |
0.745 | -0.147 | 1 | 0.732 |
TYK2 |
0.744 | -0.180 | 1 | 0.759 |
YES1 |
0.743 | -0.041 | -1 | 0.840 |
MST1R |
0.743 | -0.173 | 3 | 0.738 |
TYRO3 |
0.742 | -0.173 | 3 | 0.737 |
JAK2 |
0.742 | -0.160 | 1 | 0.758 |
CSF1R |
0.740 | -0.130 | 3 | 0.717 |
EPHA4 |
0.740 | -0.054 | 2 | 0.742 |
TNK2 |
0.740 | -0.063 | 3 | 0.679 |
INSRR |
0.740 | -0.088 | 3 | 0.695 |
BLK |
0.739 | 0.026 | -1 | 0.824 |
SRMS |
0.739 | -0.077 | 1 | 0.838 |
ABL1 |
0.738 | -0.065 | -1 | 0.796 |
JAK3 |
0.738 | -0.130 | 1 | 0.735 |
LCK |
0.738 | -0.014 | -1 | 0.816 |
TNK1 |
0.738 | -0.065 | 3 | 0.722 |
EPHB1 |
0.738 | -0.090 | 1 | 0.832 |
TNNI3K_TYR |
0.737 | -0.033 | 1 | 0.801 |
EPHB3 |
0.736 | -0.083 | -1 | 0.813 |
HCK |
0.736 | -0.096 | -1 | 0.815 |
EPHB2 |
0.736 | -0.059 | -1 | 0.806 |
ITK |
0.736 | -0.095 | -1 | 0.793 |
FGFR2 |
0.735 | -0.140 | 3 | 0.741 |
STLK3 |
0.734 | -0.215 | 1 | 0.703 |
FYN |
0.734 | 0.013 | -1 | 0.795 |
PDGFRB |
0.733 | -0.185 | 3 | 0.731 |
MERTK |
0.732 | -0.106 | 3 | 0.713 |
AXL |
0.732 | -0.141 | 3 | 0.713 |
NEK10_TYR |
0.731 | -0.133 | 1 | 0.596 |
JAK1 |
0.731 | -0.105 | 1 | 0.699 |
KIT |
0.731 | -0.169 | 3 | 0.718 |
KDR |
0.730 | -0.153 | 3 | 0.682 |
BMX |
0.730 | -0.080 | -1 | 0.705 |
MET |
0.729 | -0.132 | 3 | 0.710 |
FLT3 |
0.729 | -0.195 | 3 | 0.722 |
DDR2 |
0.728 | -0.028 | 3 | 0.670 |
EPHA7 |
0.728 | -0.089 | 2 | 0.744 |
FGFR1 |
0.727 | -0.195 | 3 | 0.704 |
TEK |
0.727 | -0.206 | 3 | 0.676 |
PTK6 |
0.727 | -0.177 | -1 | 0.734 |
TEC |
0.727 | -0.132 | -1 | 0.720 |
WEE1_TYR |
0.726 | -0.141 | -1 | 0.757 |
LTK |
0.726 | -0.145 | 3 | 0.668 |
CK1G3 |
0.726 | -0.081 | -3 | 0.283 |
ALK |
0.726 | -0.169 | 3 | 0.647 |
EPHA3 |
0.724 | -0.155 | 2 | 0.719 |
FLT1 |
0.723 | -0.146 | -1 | 0.854 |
PDGFRA |
0.723 | -0.267 | 3 | 0.726 |
NTRK1 |
0.723 | -0.212 | -1 | 0.821 |
EPHA1 |
0.723 | -0.152 | 3 | 0.684 |
BTK |
0.723 | -0.241 | -1 | 0.759 |
EPHA5 |
0.722 | -0.085 | 2 | 0.735 |
LYN |
0.722 | -0.109 | 3 | 0.649 |
FGFR3 |
0.722 | -0.178 | 3 | 0.710 |
INSR |
0.721 | -0.163 | 3 | 0.672 |
ERBB2 |
0.721 | -0.179 | 1 | 0.736 |
EGFR |
0.720 | -0.063 | 1 | 0.662 |
NTRK3 |
0.720 | -0.142 | -1 | 0.775 |
SRC |
0.720 | -0.079 | -1 | 0.794 |
EPHA8 |
0.719 | -0.092 | -1 | 0.806 |
FRK |
0.719 | -0.150 | -1 | 0.828 |
PTK2 |
0.719 | -0.019 | -1 | 0.780 |
SYK |
0.719 | -0.008 | -1 | 0.783 |
PTK2B |
0.718 | -0.118 | -1 | 0.744 |
MATK |
0.718 | -0.142 | -1 | 0.748 |
YANK2 |
0.717 | -0.115 | 2 | 0.386 |
FLT4 |
0.717 | -0.225 | 3 | 0.689 |
CSK |
0.717 | -0.139 | 2 | 0.746 |
NTRK2 |
0.716 | -0.254 | 3 | 0.683 |
FGFR4 |
0.713 | -0.120 | -1 | 0.779 |
CK1G2 |
0.711 | -0.075 | -3 | 0.367 |
EPHA2 |
0.708 | -0.109 | -1 | 0.771 |
IGF1R |
0.708 | -0.147 | 3 | 0.617 |
ERBB4 |
0.707 | -0.072 | 1 | 0.701 |
MUSK |
0.700 | -0.189 | 1 | 0.642 |
ZAP70 |
0.691 | -0.077 | -1 | 0.696 |
FES |
0.687 | -0.210 | -1 | 0.684 |