Motif 516 (n=179)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQJ8 | ATRIP | S34 | ochoa | ATR interacting protein | None |
| A1KXE4 | FAM168B | S64 | ochoa | Myelin-associated neurite-outgrowth inhibitor (Mani) (p20) | Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. {ECO:0000250|UniProtKB:D4AEP3}. |
| A6H8Y1 | BDP1 | S2451 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A8CG34 | POM121C | S246 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| D6RIA3 | C4orf54 | S895 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| O00515 | LAD1 | S123 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14917 | PCDH17 | S1038 | ochoa | Protocadherin-17 (Protocadherin-68) | Potential calcium-dependent cell-adhesion protein. |
| O15085 | ARHGEF11 | S549 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15151 | MDM4 | S342 | ochoa|psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O43353 | RIPK2 | S357 | ochoa | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| O43707 | ACTN4 | S608 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60673 | REV3L | S402 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O75175 | CNOT3 | S299 | ochoa | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}. |
| O75376 | NCOR1 | S992 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94967 | WDR47 | Y294 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95071 | UBR5 | S2028 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95436 | SLC34A2 | S55 | ochoa | Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) | Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}. |
| O95674 | CDS2 | S37 | ochoa | Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) | Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}. |
| O95758 | PTBP3 | S454 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| P02724 | GYPA | S123 | ochoa | Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:15331714}.; FUNCTION: (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. {ECO:0000269|PubMed:8009226}. |
| P04049 | RAF1 | S289 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P08581 | MET | S990 | ochoa | Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}. |
| P08631 | HCK | S45 | ochoa | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P08670 | VIM | S49 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P15923 | TCF3 | S352 | ochoa|psp | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P17302 | GJA1 | S330 | ochoa|psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P23497 | SP100 | S191 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P25054 | APC | S2330 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27816 | MAP4 | S179 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30291 | WEE1 | S123 | psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P30414 | NKTR | S613 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30622 | CLIP1 | S160 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P31150 | GDI1 | S215 | ochoa | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}. |
| P35269 | GTF2F1 | S433 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35611 | ADD1 | S483 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P41212 | ETV6 | S323 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P46821 | MAP1B | S1389 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S1646 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49023 | PXN | S322 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P50395 | GDI2 | S215 | ochoa | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P50570 | DNM2 | S742 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
| P55201 | BRPF1 | S77 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P57682 | KLF3 | S101 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P61978 | HNRNPK | S216 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P78312 | FAM193A | S270 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78411 | IRX5 | S385 | ochoa | Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) | Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}. |
| P78559 | MAP1A | S2085 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q06413 | MEF2C | S183 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q06455 | RUNX1T1 | S410 | ochoa | Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:10688654, PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| Q08495 | DMTN | S87 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q08AD1 | CAMSAP2 | S963 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12802 | AKAP13 | S783 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12851 | MAP4K2 | S387 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q13137 | CALCOCO2 | S390 | ochoa | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}. |
| Q13428 | TCOF1 | S1201 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13469 | NFATC2 | S801 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13796 | SHROOM2 | S415 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13873 | BMPR2 | S515 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q14004 | CDK13 | S342 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14202 | ZMYM3 | S774 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14202 | ZMYM3 | S1049 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14244 | MAP7 | S202 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14680 | MELK | S338 | ochoa | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q15139 | PRKD1 | S397 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15599 | NHERF2 | S254 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15678 | PTPN14 | S314 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q16594 | TAF9 | S196 | ochoa | Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}. |
| Q16666 | IFI16 | S168 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q2KJY2 | KIF26B | S1773 | ochoa|psp | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q3KQU3 | MAP7D1 | S273 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3KR16 | PLEKHG6 | S537 | ochoa | Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) | Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}. |
| Q5H9R7 | PPP6R3 | S853 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JSZ5 | PRRC2B | S1224 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T200 | ZC3H13 | S318 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5P2 | KIAA1217 | S1704 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T5Y3 | CAMSAP1 | S722 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TH69 | ARFGEF3 | S288 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5U5Q3 | MEX3C | S320 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q5VT52 | RPRD2 | S438 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q63HN8 | RNF213 | S69 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q641Q2 | WASHC2A | S787 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q659A1 | ICE2 | S418 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q68DQ2 | CRYBG3 | S629 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6IBW4 | NCAPH2 | S284 | ochoa|psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6KC79 | NIPBL | S150 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NUJ5 | PWWP2B | S458 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6P9H4 | CNKSR3 | S479 | ochoa | Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) | Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}. |
| Q6PIJ6 | FBXO38 | S717 | ochoa | F-box only protein 38 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
| Q6PIY7 | TENT2 | S62 | ochoa|psp | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
| Q6R327 | RICTOR | S1346 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6T4R5 | NHS | S993 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6W2J9 | BCOR | S367 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6YHK3 | CD109 | S1129 | ochoa | CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) | Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269|PubMed:16754747}. |
| Q6ZSR9 | None | S287 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q6ZV73 | FGD6 | S228 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q76L83 | ASXL2 | S139 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7KZI7 | MARK2 | S479 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7LBC6 | KDM3B | S727 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z3C6 | ATG9A | S656 | ochoa|psp | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q7Z3K3 | POGZ | S256 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z422 | SZRD1 | S107 | ochoa | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | None |
| Q7Z589 | EMSY | S213 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q7Z591 | AKNA | S316 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z739 | YTHDF3 | S385 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
| Q86TB9 | PATL1 | S278 | ochoa | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| Q86VY9 | TMEM200A | S31 | ochoa | Transmembrane protein 200A | None |
| Q86WB0 | ZC3HC1 | S163 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86YV5 | PRAG1 | S148 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IV63 | VRK3 | S129 | ochoa|psp | Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250|UniProtKB:Q8K3G5, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289, ECO:0000269|PubMed:25899223, ECO:0000269|PubMed:27346674, ECO:0000269|PubMed:27941812}. |
| Q8IXJ9 | ASXL1 | S503 | ochoa | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}. |
| Q8IZ21 | PHACTR4 | S118 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8IZD2 | KMT2E | S1291 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8IZT6 | ASPM | S3428 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N1G0 | ZNF687 | S1184 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N1I0 | DOCK4 | S1620 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N612 | FHIP1B | S516 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8NCD3 | HJURP | S557 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NCP5 | ZBTB44 | S161 | ochoa | Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851) | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q8NEM2 | SHCBP1 | S44 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NEM7 | SUPT20H | S430 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NEN9 | PDZD8 | S521 | ochoa | PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. |
| Q8NFC6 | BOD1L1 | S1318 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHY2 | COP1 | S110 | ochoa | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). {ECO:0000269|PubMed:12466024, ECO:0000269|PubMed:12615916, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15103385, ECO:0000269|PubMed:19805145, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21625211, ECO:0000303|PubMed:27041596}. |
| Q8TD16 | BICD2 | S608 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TE68 | EPS8L1 | S239 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8WX93 | PALLD | S1335 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE1 | ATRIP | S221 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WXI2 | CNKSR2 | S390 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Q92615 | LARP4B | S601 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92619 | ARHGAP45 | S25 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92628 | KIAA0232 | S158 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q969S3 | ZNF622 | S143 | ochoa | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q96BY7 | ATG2B | S495 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96CX2 | KCTD12 | S185 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96GD4 | AURKB | S45 | ochoa | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
| Q96HA1 | POM121 | S269 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96HP0 | DOCK6 | S178 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96JK2 | DCAF5 | S461 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96JM3 | CHAMP1 | S445 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96KR1 | ZFR | S481 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96MM6 | HSPA12B | S46 | ochoa | Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B) | None |
| Q96NU1 | SAMD11 | S171 | ochoa | Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}. |
| Q96PK6 | RBM14 | S620 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96QF0 | RAB3IP | S263 | ochoa | Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (Rabin8) (SSX2-interacting protein) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879, PubMed:31204173). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:31204173}. |
| Q96QT4 | TRPM7 | S1569 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96SD1 | DCLRE1C | S518 | ochoa | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. |
| Q96T37 | RBM15 | S259 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99747 | NAPG | S284 | ochoa | Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. |
| Q9BQ65 | USB1 | S36 | ochoa | U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1) | 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367). {ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23022480, ECO:0000269|PubMed:23190533, ECO:0000269|PubMed:26213367, ECO:0000269|PubMed:28887445, ECO:0000269|PubMed:30215753, ECO:0000269|PubMed:31832688}. |
| Q9BST9 | RTKN | S108 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9BXB5 | OSBPL10 | S507 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BXW9 | FANCD2 | S592 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BY89 | KIAA1671 | S458 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BY89 | KIAA1671 | S1012 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZH6 | WDR11 | S399 | ochoa | WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) | Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). {ECO:0000269|PubMed:29263200, ECO:0000269|PubMed:29426865}. |
| Q9H0H5 | RACGAP1 | S187 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H0L4 | CSTF2T | S563 | ochoa | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| Q9H1B7 | IRF2BPL | S659 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H2P0 | ADNP | S738 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4L5 | OSBPL3 | S766 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H5V7 | IKZF5 | S309 | ochoa | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}. |
| Q9H6K5 | PRR36 | S1109 | ochoa | Proline-rich protein 36 | None |
| Q9H8M2 | BRD9 | S568 | ochoa | Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) | Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}. |
| Q9H8W4 | PLEKHF2 | S226 | ochoa | Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18) | May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}. |
| Q9NQG5 | RPRD1B | S166 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q9NQW6 | ANLN | S99 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR19 | ACSS2 | S267 | ochoa|psp | Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (PubMed:28552616). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (PubMed:28552616). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (PubMed:28552616). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity). {ECO:0000250|UniProtKB:Q9QXG4, ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429, ECO:0000269|PubMed:28552616}. |
| Q9NYL2 | MAP3K20 | S720 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P0U4 | CXXC1 | S138 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P2F8 | SIPA1L2 | S1554 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UHF7 | TRPS1 | S90 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UKE5 | TNIK | S574 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9ULD4 | BRPF3 | S19 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULH1 | ASAP1 | S746 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULJ3 | ZBTB21 | S415 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UPW6 | SATB2 | S20 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9Y2V2 | CARHSP1 | S32 | ochoa|psp | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9Y3R5 | DOP1B | S714 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y6Y8 | SEC23IP | S742 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.011914 | 1.924 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.023687 | 1.625 |
| R-HSA-9734091 | Drug-mediated inhibition of MET activation | 0.023687 | 1.625 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.023687 | 1.625 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.023687 | 1.625 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.023687 | 1.625 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.023687 | 1.625 |
| R-HSA-5619045 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | 0.035321 | 1.452 |
| R-HSA-5687583 | Defective SLC34A2 causes PALM | 0.035321 | 1.452 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.058175 | 1.235 |
| R-HSA-8865999 | MET activates PTPN11 | 0.058175 | 1.235 |
| R-HSA-196025 | Formation of annular gap junctions | 0.007929 | 2.101 |
| R-HSA-190873 | Gap junction degradation | 0.009363 | 2.029 |
| R-HSA-191650 | Regulation of gap junction activity | 0.069400 | 1.159 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.080491 | 1.094 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.091451 | 1.039 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.102281 | 0.990 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.112983 | 0.947 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.112983 | 0.947 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.112983 | 0.947 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.112983 | 0.947 |
| R-HSA-8875656 | MET receptor recycling | 0.123557 | 0.908 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.123557 | 0.908 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.123557 | 0.908 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.144332 | 0.841 |
| R-HSA-4839744 | Signaling by APC mutants | 0.154534 | 0.811 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.154534 | 0.811 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.154534 | 0.811 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.154534 | 0.811 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.164616 | 0.784 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.164616 | 0.784 |
| R-HSA-8851805 | MET activates RAS signaling | 0.174578 | 0.758 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.174578 | 0.758 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.174578 | 0.758 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.174578 | 0.758 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.174578 | 0.758 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.174578 | 0.758 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.184422 | 0.734 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.066678 | 1.176 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.070006 | 1.155 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.073387 | 1.134 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.073387 | 1.134 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.203761 | 0.691 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.203761 | 0.691 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.080303 | 1.095 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.080303 | 1.095 |
| R-HSA-390522 | Striated Muscle Contraction | 0.083834 | 1.077 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.083834 | 1.077 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.213259 | 0.671 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.091034 | 1.041 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.222644 | 0.652 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.222644 | 0.652 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.231917 | 0.635 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.105944 | 0.975 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.109769 | 0.960 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.109769 | 0.960 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.250136 | 0.602 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.117526 | 0.930 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.117526 | 0.930 |
| R-HSA-167161 | HIV Transcription Initiation | 0.117526 | 0.930 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.117526 | 0.930 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.259083 | 0.587 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.125415 | 0.902 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.133428 | 0.875 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.137477 | 0.862 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.218254 | 0.661 |
| R-HSA-167172 | Transcription of the HIV genome | 0.231425 | 0.636 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.137477 | 0.862 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.137477 | 0.862 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.104475 | 0.981 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.117526 | 0.930 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.240235 | 0.619 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.006071 | 2.217 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.036734 | 1.435 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.222644 | 0.652 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.137477 | 0.862 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.112983 | 0.947 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.276660 | 0.558 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.253477 | 0.596 |
| R-HSA-69541 | Stabilization of p53 | 0.105944 | 0.975 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.040804 | 1.389 |
| R-HSA-4641265 | Repression of WNT target genes | 0.174578 | 0.758 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.149780 | 0.825 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.105944 | 0.975 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.009363 | 2.029 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.098409 | 1.007 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.241081 | 0.618 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.133428 | 0.875 |
| R-HSA-190828 | Gap junction trafficking | 0.129407 | 0.888 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.257896 | 0.589 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.053934 | 1.268 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.276660 | 0.558 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.127395 | 0.895 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.033827 | 1.471 |
| R-HSA-6806942 | MET Receptor Activation | 0.102281 | 0.990 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.112983 | 0.947 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.036734 | 1.435 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.203761 | 0.691 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.113630 | 0.945 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.068273 | 1.166 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.276660 | 0.558 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.208486 | 0.681 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 0.035321 | 1.452 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.046816 | 1.330 |
| R-HSA-8875791 | MET activates STAT3 | 0.058175 | 1.235 |
| R-HSA-427589 | Type II Na+/Pi cotransporters | 0.058175 | 1.235 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.102281 | 0.990 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.112983 | 0.947 |
| R-HSA-202670 | ERKs are inactivated | 0.164616 | 0.784 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.164616 | 0.784 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.164616 | 0.784 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.098409 | 1.007 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.051004 | 1.292 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.250136 | 0.602 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.133428 | 0.875 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.149780 | 0.825 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.149780 | 0.825 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.241081 | 0.618 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.137911 | 0.860 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.094700 | 1.024 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.250136 | 0.602 |
| R-HSA-162587 | HIV Life Cycle | 0.159937 | 0.796 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.009363 | 2.029 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.184422 | 0.734 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.083834 | 1.077 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.047497 | 1.323 |
| R-HSA-9707616 | Heme signaling | 0.205153 | 0.688 |
| R-HSA-199991 | Membrane Trafficking | 0.108629 | 0.964 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.070337 | 1.153 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.105944 | 0.975 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.250136 | 0.602 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.155040 | 0.810 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.124751 | 0.904 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 0.035321 | 1.452 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.091451 | 1.039 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.020104 | 1.697 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.164616 | 0.784 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.194149 | 0.712 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.267924 | 0.572 |
| R-HSA-191859 | snRNP Assembly | 0.192145 | 0.716 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.192145 | 0.716 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.209510 | 0.679 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.257896 | 0.589 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.119212 | 0.924 |
| R-HSA-162906 | HIV Infection | 0.176784 | 0.753 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.274108 | 0.562 |
| R-HSA-9733709 | Cardiogenesis | 0.080303 | 1.095 |
| R-HSA-198753 | ERK/MAPK targets | 0.039426 | 1.404 |
| R-HSA-525793 | Myogenesis | 0.057031 | 1.244 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.080303 | 1.095 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.087412 | 1.058 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.259083 | 0.587 |
| R-HSA-114608 | Platelet degranulation | 0.092613 | 1.033 |
| R-HSA-68875 | Mitotic Prophase | 0.217774 | 0.662 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.006604 | 2.180 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.069400 | 1.159 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.069400 | 1.159 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.091451 | 1.039 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.004387 | 2.358 |
| R-HSA-429947 | Deadenylation of mRNA | 0.050900 | 1.293 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.164616 | 0.784 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.109769 | 0.960 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.109769 | 0.960 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.113630 | 0.945 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.249060 | 0.604 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.006036 | 2.219 |
| R-HSA-73886 | Chromosome Maintenance | 0.220889 | 0.656 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.004021 | 2.396 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.134006 | 0.873 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.098409 | 1.007 |
| R-HSA-983189 | Kinesins | 0.196469 | 0.707 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.105539 | 0.977 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.091451 | 1.039 |
| R-HSA-164944 | Nef and signal transduction | 0.102281 | 0.990 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.174578 | 0.758 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.174578 | 0.758 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.174578 | 0.758 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.203761 | 0.691 |
| R-HSA-1483148 | Synthesis of PG | 0.222644 | 0.652 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.102157 | 0.991 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.137477 | 0.862 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.276660 | 0.558 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.249060 | 0.604 |
| R-HSA-373755 | Semaphorin interactions | 0.209510 | 0.679 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.028255 | 1.549 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.225116 | 0.648 |
| R-HSA-5689603 | UCH proteinases | 0.266737 | 0.574 |
| R-HSA-3371556 | Cellular response to heat stress | 0.220889 | 0.656 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.091034 | 1.041 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.222644 | 0.652 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.105944 | 0.975 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.183536 | 0.736 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.184422 | 0.734 |
| R-HSA-9635465 | Suppression of apoptosis | 0.154534 | 0.811 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.174578 | 0.758 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.080303 | 1.095 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.098409 | 1.007 |
| R-HSA-392517 | Rap1 signalling | 0.250136 | 0.602 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.179254 | 0.747 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.205153 | 0.688 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.059470 | 1.226 |
| R-HSA-9834899 | Specification of the neural plate border | 0.250136 | 0.602 |
| R-HSA-3214847 | HATs acetylate histones | 0.044363 | 1.353 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.240235 | 0.619 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.011114 | 1.954 |
| R-HSA-1640170 | Cell Cycle | 0.100935 | 0.996 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.066678 | 1.176 |
| R-HSA-450294 | MAP kinase activation | 0.051004 | 1.292 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.155040 | 0.810 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.085508 | 1.068 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.080303 | 1.095 |
| R-HSA-448424 | Interleukin-17 signaling | 0.068273 | 1.166 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.174578 | 0.758 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.083834 | 1.077 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.230288 | 0.638 |
| R-HSA-74160 | Gene expression (Transcription) | 0.033458 | 1.475 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.002368 | 2.626 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.057170 | 1.243 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.250136 | 0.602 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.203761 | 0.691 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.031576 | 1.501 |
| R-HSA-180292 | GAB1 signalosome | 0.241081 | 0.618 |
| R-HSA-75153 | Apoptotic execution phase | 0.027786 | 1.556 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.241081 | 0.618 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.276660 | 0.558 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.175299 | 0.756 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.001419 | 2.848 |
| R-HSA-5688426 | Deubiquitination | 0.235561 | 0.628 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.057031 | 1.244 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.203761 | 0.691 |
| R-HSA-373753 | Nephrin family interactions | 0.259083 | 0.587 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.001000 | 3.000 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.045026 | 1.347 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.143818 | 0.842 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.143818 | 0.842 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.143818 | 0.842 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.241081 | 0.618 |
| R-HSA-4839726 | Chromatin organization | 0.044650 | 1.350 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.178253 | 0.749 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.275577 | 0.560 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.181220 | 0.742 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.214668 | 0.668 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.181220 | 0.742 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.214668 | 0.668 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.224013 | 0.650 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.166525 | 0.779 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.094700 | 1.024 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.072428 | 1.140 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.092462 | 1.034 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.262316 | 0.581 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.224013 | 0.650 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.052930 | 1.276 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.253477 | 0.596 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.190200 | 0.721 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.086831 | 1.061 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.199292 | 0.701 |
| R-HSA-212436 | Generic Transcription Pathway | 0.131260 | 0.882 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.208486 | 0.681 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.140055 | 0.854 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.149798 | 0.824 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.028255 | 1.549 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.146597 | 0.834 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.246111 | 0.609 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.034193 | 1.466 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.245361 | 0.610 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.183536 | 0.736 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.055126 | 1.259 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.119238 | 0.924 |
| R-HSA-449147 | Signaling by Interleukins | 0.248863 | 0.604 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.278195 | 0.556 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.285292 | 0.545 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.285292 | 0.545 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.285292 | 0.545 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.285292 | 0.545 |
| R-HSA-71384 | Ethanol oxidation | 0.285292 | 0.545 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.289677 | 0.538 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.292706 | 0.534 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.293238 | 0.533 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.293822 | 0.532 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.293822 | 0.532 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.293822 | 0.532 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.293822 | 0.532 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.300934 | 0.522 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.302251 | 0.520 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.302251 | 0.520 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.306447 | 0.514 |
| R-HSA-9839394 | TGFBR3 expression | 0.310579 | 0.508 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.310579 | 0.508 |
| R-HSA-3214842 | HDMs demethylate histones | 0.310579 | 0.508 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.310579 | 0.508 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.310579 | 0.508 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.310841 | 0.507 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.310841 | 0.507 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.318809 | 0.496 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.318809 | 0.496 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.318809 | 0.496 |
| R-HSA-3295583 | TRP channels | 0.318809 | 0.496 |
| R-HSA-166520 | Signaling by NTRKs | 0.320483 | 0.494 |
| R-HSA-9663891 | Selective autophagy | 0.323985 | 0.489 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.326941 | 0.486 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.326941 | 0.486 |
| R-HSA-201451 | Signaling by BMP | 0.326941 | 0.486 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.326941 | 0.486 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.326941 | 0.486 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.334303 | 0.476 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.334976 | 0.475 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.334976 | 0.475 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.334976 | 0.475 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.334976 | 0.475 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.334976 | 0.475 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.334976 | 0.475 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.334976 | 0.475 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.340046 | 0.468 |
| R-HSA-73887 | Death Receptor Signaling | 0.340046 | 0.468 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.342916 | 0.465 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.342916 | 0.465 |
| R-HSA-72086 | mRNA Capping | 0.342916 | 0.465 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.342916 | 0.465 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.343305 | 0.464 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.346524 | 0.460 |
| R-HSA-9610379 | HCMV Late Events | 0.349818 | 0.456 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.350486 | 0.455 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.350762 | 0.455 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.350762 | 0.455 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.350762 | 0.455 |
| R-HSA-68886 | M Phase | 0.353867 | 0.451 |
| R-HSA-877300 | Interferon gamma signaling | 0.356324 | 0.448 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.359575 | 0.444 |
| R-HSA-109581 | Apoptosis | 0.366068 | 0.436 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.366174 | 0.436 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.366174 | 0.436 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.366174 | 0.436 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.367275 | 0.435 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.367275 | 0.435 |
| R-HSA-157579 | Telomere Maintenance | 0.371549 | 0.430 |
| R-HSA-109582 | Hemostasis | 0.371875 | 0.430 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.373744 | 0.427 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.373744 | 0.427 |
| R-HSA-5619102 | SLC transporter disorders | 0.382253 | 0.418 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.384301 | 0.415 |
| R-HSA-70171 | Glycolysis | 0.384301 | 0.415 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.388613 | 0.410 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.388613 | 0.410 |
| R-HSA-5673000 | RAF activation | 0.388613 | 0.410 |
| R-HSA-190861 | Gap junction assembly | 0.388613 | 0.410 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.388613 | 0.410 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.388613 | 0.410 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.388613 | 0.410 |
| R-HSA-5205647 | Mitophagy | 0.388613 | 0.410 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.395916 | 0.402 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.395916 | 0.402 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.398346 | 0.400 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.403132 | 0.395 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.403132 | 0.395 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.403132 | 0.395 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.403132 | 0.395 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.403132 | 0.395 |
| R-HSA-9609646 | HCMV Infection | 0.405935 | 0.392 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.406642 | 0.391 |
| R-HSA-8875878 | MET promotes cell motility | 0.417307 | 0.380 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.417307 | 0.380 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.417307 | 0.380 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.417307 | 0.380 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.417739 | 0.379 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.417739 | 0.379 |
| R-HSA-211000 | Gene Silencing by RNA | 0.417739 | 0.379 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.421855 | 0.375 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.421855 | 0.375 |
| R-HSA-168255 | Influenza Infection | 0.423852 | 0.373 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.424269 | 0.372 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.425957 | 0.371 |
| R-HSA-2559583 | Cellular Senescence | 0.427015 | 0.370 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.431148 | 0.365 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.431148 | 0.365 |
| R-HSA-167169 | HIV Transcription Elongation | 0.431148 | 0.365 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.431148 | 0.365 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.431148 | 0.365 |
| R-HSA-9646399 | Aggrephagy | 0.431148 | 0.365 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.437945 | 0.359 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.437945 | 0.359 |
| R-HSA-9607240 | FLT3 Signaling | 0.437945 | 0.359 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.438171 | 0.358 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.444661 | 0.352 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.444661 | 0.352 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.446235 | 0.350 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.451298 | 0.346 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.457855 | 0.339 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.458210 | 0.339 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.458210 | 0.339 |
| R-HSA-5617833 | Cilium Assembly | 0.458297 | 0.339 |
| R-HSA-5683826 | Surfactant metabolism | 0.464335 | 0.333 |
| R-HSA-70326 | Glucose metabolism | 0.466110 | 0.332 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.470035 | 0.328 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.470738 | 0.327 |
| R-HSA-774815 | Nucleosome assembly | 0.470738 | 0.327 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.473943 | 0.324 |
| R-HSA-9609690 | HCMV Early Events | 0.476721 | 0.322 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.477064 | 0.321 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.477064 | 0.321 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.477064 | 0.321 |
| R-HSA-9675135 | Diseases of DNA repair | 0.477064 | 0.321 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.481705 | 0.317 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.483315 | 0.316 |
| R-HSA-437239 | Recycling pathway of L1 | 0.483315 | 0.316 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.483315 | 0.316 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.489398 | 0.310 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.489398 | 0.310 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.489492 | 0.310 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.489492 | 0.310 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.489492 | 0.310 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.489492 | 0.310 |
| R-HSA-73893 | DNA Damage Bypass | 0.495595 | 0.305 |
| R-HSA-9766229 | Degradation of CDH1 | 0.495595 | 0.305 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.495595 | 0.305 |
| R-HSA-194138 | Signaling by VEGF | 0.500803 | 0.300 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.501626 | 0.300 |
| R-HSA-5357801 | Programmed Cell Death | 0.506769 | 0.295 |
| R-HSA-69481 | G2/M Checkpoints | 0.508315 | 0.294 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.513473 | 0.289 |
| R-HSA-72187 | mRNA 3'-end processing | 0.513473 | 0.289 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.519292 | 0.285 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.519292 | 0.285 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.519292 | 0.285 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.519292 | 0.285 |
| R-HSA-397014 | Muscle contraction | 0.527267 | 0.278 |
| R-HSA-9909396 | Circadian clock | 0.530407 | 0.275 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.530721 | 0.275 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.530721 | 0.275 |
| R-HSA-913531 | Interferon Signaling | 0.533309 | 0.273 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.536334 | 0.271 |
| R-HSA-177929 | Signaling by EGFR | 0.536334 | 0.271 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.536802 | 0.270 |
| R-HSA-68882 | Mitotic Anaphase | 0.538768 | 0.269 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.541619 | 0.266 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.541880 | 0.266 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.547360 | 0.262 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.547360 | 0.262 |
| R-HSA-180786 | Extension of Telomeres | 0.552775 | 0.257 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.558125 | 0.253 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.558125 | 0.253 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.558125 | 0.253 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.558125 | 0.253 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.558125 | 0.253 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.558125 | 0.253 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.558125 | 0.253 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.558125 | 0.253 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.563412 | 0.249 |
| R-HSA-1632852 | Macroautophagy | 0.565709 | 0.247 |
| R-HSA-8848021 | Signaling by PTK6 | 0.573798 | 0.241 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.573798 | 0.241 |
| R-HSA-1500931 | Cell-Cell communication | 0.573905 | 0.241 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.578898 | 0.237 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.588917 | 0.230 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.593837 | 0.226 |
| R-HSA-2262752 | Cellular responses to stress | 0.594422 | 0.226 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.608249 | 0.216 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.608249 | 0.216 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.608249 | 0.216 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.608704 | 0.216 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.611874 | 0.213 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.612939 | 0.213 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.612939 | 0.213 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.617573 | 0.209 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.617573 | 0.209 |
| R-HSA-9612973 | Autophagy | 0.618157 | 0.209 |
| R-HSA-4086398 | Ca2+ pathway | 0.622152 | 0.206 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.622209 | 0.206 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.624361 | 0.205 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.626676 | 0.203 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.626676 | 0.203 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.635564 | 0.197 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.639928 | 0.194 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.642509 | 0.192 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.644241 | 0.191 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.647331 | 0.189 |
| R-HSA-6806834 | Signaling by MET | 0.652713 | 0.185 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.652713 | 0.185 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.652713 | 0.185 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.652713 | 0.185 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.656873 | 0.183 |
| R-HSA-72306 | tRNA processing | 0.662805 | 0.179 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.665045 | 0.177 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.669058 | 0.175 |
| R-HSA-73894 | DNA Repair | 0.669880 | 0.174 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.671217 | 0.173 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.671217 | 0.173 |
| R-HSA-446728 | Cell junction organization | 0.694830 | 0.158 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.695843 | 0.157 |
| R-HSA-202424 | Downstream TCR signaling | 0.695843 | 0.157 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.698039 | 0.156 |
| R-HSA-69275 | G2/M Transition | 0.705727 | 0.151 |
| R-HSA-2029481 | FCGR activation | 0.710168 | 0.149 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.710761 | 0.148 |
| R-HSA-983712 | Ion channel transport | 0.713251 | 0.147 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.713644 | 0.147 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.717940 | 0.144 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.720615 | 0.142 |
| R-HSA-68877 | Mitotic Prometaphase | 0.723034 | 0.141 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.723823 | 0.140 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.725435 | 0.139 |
| R-HSA-597592 | Post-translational protein modification | 0.726096 | 0.139 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.727135 | 0.138 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.727135 | 0.138 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.730186 | 0.137 |
| R-HSA-190236 | Signaling by FGFR | 0.730408 | 0.136 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.731932 | 0.136 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.733641 | 0.135 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.739993 | 0.131 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.746269 | 0.127 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.746269 | 0.127 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.749240 | 0.125 |
| R-HSA-72172 | mRNA Splicing | 0.750712 | 0.125 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.752249 | 0.124 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.752249 | 0.124 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.752249 | 0.124 |
| R-HSA-9833110 | RSV-host interactions | 0.752249 | 0.124 |
| R-HSA-162582 | Signal Transduction | 0.768595 | 0.114 |
| R-HSA-202403 | TCR signaling | 0.769563 | 0.114 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.769563 | 0.114 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.779730 | 0.108 |
| R-HSA-418990 | Adherens junctions interactions | 0.779979 | 0.108 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.780432 | 0.108 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.780851 | 0.107 |
| R-HSA-8951664 | Neddylation | 0.785847 | 0.105 |
| R-HSA-373760 | L1CAM interactions | 0.790790 | 0.102 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.795323 | 0.099 |
| R-HSA-5693538 | Homology Directed Repair | 0.795786 | 0.099 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.803057 | 0.095 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.807761 | 0.093 |
| R-HSA-8953854 | Metabolism of RNA | 0.809619 | 0.092 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.814608 | 0.089 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.814608 | 0.089 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.814608 | 0.089 |
| R-HSA-69206 | G1/S Transition | 0.814608 | 0.089 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.816836 | 0.088 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.817971 | 0.087 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.825485 | 0.083 |
| R-HSA-1280218 | Adaptive Immune System | 0.828836 | 0.082 |
| R-HSA-9843745 | Adipogenesis | 0.829656 | 0.081 |
| R-HSA-421270 | Cell-cell junction organization | 0.837359 | 0.077 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.841583 | 0.075 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.841583 | 0.075 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.843488 | 0.074 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.844773 | 0.073 |
| R-HSA-9664407 | Parasite infection | 0.849069 | 0.071 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.849069 | 0.071 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.849069 | 0.071 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.854640 | 0.068 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.856203 | 0.067 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.861332 | 0.065 |
| R-HSA-69242 | S Phase | 0.864650 | 0.063 |
| R-HSA-9758941 | Gastrulation | 0.866280 | 0.062 |
| R-HSA-1989781 | PPARA activates gene expression | 0.875653 | 0.058 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.878614 | 0.056 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.878630 | 0.056 |
| R-HSA-9824446 | Viral Infection Pathways | 0.887622 | 0.052 |
| R-HSA-168249 | Innate Immune System | 0.892117 | 0.050 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.892866 | 0.049 |
| R-HSA-1483257 | Phospholipid metabolism | 0.892866 | 0.049 |
| R-HSA-195721 | Signaling by WNT | 0.895927 | 0.048 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.900030 | 0.046 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.901235 | 0.045 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.901235 | 0.045 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.901235 | 0.045 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.902426 | 0.045 |
| R-HSA-168256 | Immune System | 0.910578 | 0.041 |
| R-HSA-9679506 | SARS-CoV Infections | 0.916929 | 0.038 |
| R-HSA-6798695 | Neutrophil degranulation | 0.927746 | 0.033 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.928838 | 0.032 |
| R-HSA-428157 | Sphingolipid metabolism | 0.929698 | 0.032 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.932438 | 0.030 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.945251 | 0.024 |
| R-HSA-8939211 | ESR-mediated signaling | 0.955179 | 0.020 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.955179 | 0.020 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.955740 | 0.020 |
| R-HSA-157118 | Signaling by NOTCH | 0.956787 | 0.019 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.958789 | 0.018 |
| R-HSA-422475 | Axon guidance | 0.967317 | 0.014 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.969285 | 0.014 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.972815 | 0.012 |
| R-HSA-9658195 | Leishmania infection | 0.973793 | 0.012 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.973793 | 0.012 |
| R-HSA-9675108 | Nervous system development | 0.976885 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.978987 | 0.009 |
| R-HSA-1266738 | Developmental Biology | 0.982163 | 0.008 |
| R-HSA-8957322 | Metabolism of steroids | 0.984511 | 0.007 |
| R-HSA-392499 | Metabolism of proteins | 0.987435 | 0.005 |
| R-HSA-5663205 | Infectious disease | 0.987528 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 0.993710 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.993755 | 0.003 |
| R-HSA-1643685 | Disease | 0.994032 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.995684 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.998683 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.999371 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999758 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999955 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.835 | 0.596 | 1 | 0.912 |
HIPK2 |
0.812 | 0.486 | 1 | 0.940 |
DYRK2 |
0.808 | 0.469 | 1 | 0.907 |
CDK1 |
0.808 | 0.513 | 1 | 0.937 |
DYRK4 |
0.806 | 0.483 | 1 | 0.943 |
CLK3 |
0.805 | 0.338 | 1 | 0.754 |
CDK18 |
0.803 | 0.493 | 1 | 0.934 |
JNK2 |
0.801 | 0.528 | 1 | 0.931 |
CDK17 |
0.800 | 0.506 | 1 | 0.932 |
HIPK1 |
0.799 | 0.454 | 1 | 0.902 |
CDK3 |
0.799 | 0.452 | 1 | 0.937 |
P38G |
0.798 | 0.513 | 1 | 0.936 |
HIPK4 |
0.796 | 0.294 | 1 | 0.792 |
SRPK1 |
0.796 | 0.250 | -3 | 0.785 |
DYRK1B |
0.795 | 0.451 | 1 | 0.926 |
P38B |
0.795 | 0.480 | 1 | 0.915 |
JNK3 |
0.795 | 0.524 | 1 | 0.927 |
CDK7 |
0.795 | 0.460 | 1 | 0.929 |
CDK19 |
0.794 | 0.450 | 1 | 0.923 |
CDK8 |
0.794 | 0.449 | 1 | 0.917 |
CDK10 |
0.794 | 0.468 | 1 | 0.929 |
CLK2 |
0.792 | 0.296 | -3 | 0.768 |
CDK13 |
0.792 | 0.463 | 1 | 0.932 |
CDK16 |
0.792 | 0.481 | 1 | 0.930 |
NLK |
0.792 | 0.445 | 1 | 0.788 |
ERK1 |
0.791 | 0.477 | 1 | 0.920 |
CDK14 |
0.790 | 0.480 | 1 | 0.923 |
P38D |
0.790 | 0.483 | 1 | 0.926 |
CDK12 |
0.790 | 0.468 | 1 | 0.933 |
CDK5 |
0.789 | 0.456 | 1 | 0.916 |
GRK1 |
0.787 | 0.269 | -2 | 0.463 |
P38A |
0.785 | 0.448 | 1 | 0.898 |
DYRK3 |
0.785 | 0.346 | 1 | 0.876 |
CDK9 |
0.785 | 0.453 | 1 | 0.924 |
DYRK1A |
0.784 | 0.369 | 1 | 0.882 |
SRPK2 |
0.784 | 0.201 | -3 | 0.713 |
COT |
0.784 | 0.072 | 2 | 0.851 |
CLK4 |
0.783 | 0.244 | -3 | 0.782 |
MOS |
0.781 | 0.212 | 1 | 0.548 |
ERK2 |
0.781 | 0.478 | 1 | 0.912 |
HIPK3 |
0.781 | 0.409 | 1 | 0.869 |
JNK1 |
0.781 | 0.479 | 1 | 0.930 |
ERK5 |
0.780 | 0.231 | 1 | 0.710 |
CLK1 |
0.779 | 0.256 | -3 | 0.756 |
CDK2 |
0.778 | 0.376 | 1 | 0.874 |
SRPK3 |
0.778 | 0.198 | -3 | 0.752 |
MTOR |
0.777 | 0.135 | 1 | 0.596 |
PIM3 |
0.775 | 0.028 | -3 | 0.842 |
ICK |
0.775 | 0.205 | -3 | 0.854 |
MAK |
0.774 | 0.303 | -2 | 0.204 |
CDKL5 |
0.773 | 0.106 | -3 | 0.822 |
CDKL1 |
0.773 | 0.112 | -3 | 0.823 |
NDR2 |
0.773 | 0.031 | -3 | 0.846 |
PRP4 |
0.770 | 0.322 | -3 | 0.815 |
AURC |
0.769 | -0.003 | -2 | 0.215 |
RSK2 |
0.769 | 0.029 | -3 | 0.797 |
IKKB |
0.769 | -0.073 | -2 | 0.257 |
CDC7 |
0.769 | -0.031 | 1 | 0.493 |
CDK4 |
0.769 | 0.450 | 1 | 0.937 |
GRK7 |
0.768 | 0.179 | 1 | 0.473 |
CDK6 |
0.767 | 0.438 | 1 | 0.921 |
PRPK |
0.765 | -0.053 | -1 | 0.824 |
NDR1 |
0.764 | -0.006 | -3 | 0.833 |
CAMK1B |
0.764 | -0.010 | -3 | 0.849 |
PKACG |
0.764 | -0.010 | -2 | 0.249 |
SKMLCK |
0.764 | 0.008 | -2 | 0.293 |
BMPR1B |
0.763 | 0.080 | 1 | 0.464 |
PIM1 |
0.762 | 0.033 | -3 | 0.797 |
PRKX |
0.761 | 0.040 | -3 | 0.704 |
P90RSK |
0.761 | 0.012 | -3 | 0.805 |
ATR |
0.760 | -0.041 | 1 | 0.503 |
GRK5 |
0.760 | -0.011 | -3 | 0.813 |
DSTYK |
0.760 | -0.020 | 2 | 0.844 |
PKACB |
0.760 | 0.012 | -2 | 0.216 |
NUAK2 |
0.760 | 0.014 | -3 | 0.836 |
CAMK2G |
0.760 | -0.033 | 2 | 0.779 |
MOK |
0.759 | 0.292 | 1 | 0.831 |
RAF1 |
0.759 | -0.108 | 1 | 0.479 |
GSK3A |
0.759 | 0.201 | 4 | 0.588 |
TGFBR2 |
0.759 | -0.050 | -2 | 0.282 |
MST4 |
0.758 | -0.016 | 2 | 0.786 |
CAMLCK |
0.758 | -0.016 | -2 | 0.259 |
WNK1 |
0.758 | -0.049 | -2 | 0.284 |
PRKD2 |
0.757 | -0.014 | -3 | 0.791 |
IKKE |
0.757 | -0.127 | 1 | 0.411 |
PKN2 |
0.757 | -0.024 | -3 | 0.823 |
PDHK4 |
0.757 | -0.164 | 1 | 0.537 |
BMPR2 |
0.756 | -0.125 | -2 | 0.279 |
RSK4 |
0.756 | 0.041 | -3 | 0.779 |
GRK4 |
0.756 | 0.088 | -2 | 0.392 |
TBK1 |
0.756 | -0.134 | 1 | 0.409 |
PKN3 |
0.755 | -0.027 | -3 | 0.830 |
GCN2 |
0.755 | -0.138 | 2 | 0.757 |
GRK2 |
0.755 | 0.053 | -2 | 0.337 |
IKKA |
0.755 | -0.046 | -2 | 0.252 |
PKG2 |
0.755 | -0.019 | -2 | 0.215 |
P70S6KB |
0.755 | 0.001 | -3 | 0.800 |
AURB |
0.755 | -0.030 | -2 | 0.211 |
HUNK |
0.755 | -0.012 | 2 | 0.820 |
RIPK3 |
0.754 | -0.040 | 3 | 0.717 |
NIK |
0.754 | -0.056 | -3 | 0.853 |
PRKD1 |
0.754 | -0.047 | -3 | 0.838 |
RSK3 |
0.754 | -0.013 | -3 | 0.780 |
CK1E |
0.753 | 0.142 | -3 | 0.541 |
CHAK2 |
0.753 | -0.054 | -1 | 0.784 |
NEK6 |
0.753 | -0.089 | -2 | 0.253 |
AURA |
0.753 | -0.032 | -2 | 0.211 |
TGFBR1 |
0.753 | 0.015 | -2 | 0.301 |
DAPK2 |
0.752 | -0.041 | -3 | 0.857 |
AMPKA1 |
0.752 | -0.039 | -3 | 0.843 |
MAPKAPK2 |
0.752 | -0.013 | -3 | 0.749 |
GRK6 |
0.752 | -0.026 | 1 | 0.477 |
LATS2 |
0.751 | -0.031 | -5 | 0.840 |
MSK1 |
0.751 | -0.002 | -3 | 0.762 |
MLK1 |
0.750 | -0.074 | 2 | 0.763 |
ALK4 |
0.750 | 0.005 | -2 | 0.297 |
ULK2 |
0.750 | -0.195 | 2 | 0.745 |
AKT2 |
0.750 | 0.036 | -3 | 0.717 |
NEK7 |
0.750 | -0.130 | -3 | 0.821 |
MASTL |
0.750 | -0.113 | -2 | 0.263 |
CK1D |
0.749 | 0.158 | -3 | 0.493 |
GRK3 |
0.749 | 0.070 | -2 | 0.368 |
PAK1 |
0.749 | -0.049 | -2 | 0.244 |
MAPKAPK3 |
0.748 | -0.059 | -3 | 0.781 |
CAMK2A |
0.748 | 0.004 | 2 | 0.770 |
LATS1 |
0.748 | 0.019 | -3 | 0.861 |
MYLK4 |
0.748 | -0.013 | -2 | 0.260 |
MARK4 |
0.747 | -0.087 | 4 | 0.841 |
MSK2 |
0.747 | -0.024 | -3 | 0.766 |
PDHK1 |
0.747 | -0.230 | 1 | 0.508 |
PAK6 |
0.747 | -0.038 | -2 | 0.192 |
PKCD |
0.747 | -0.046 | 2 | 0.735 |
CAMK2D |
0.747 | -0.094 | -3 | 0.831 |
AMPKA2 |
0.746 | -0.037 | -3 | 0.819 |
PKACA |
0.746 | -0.005 | -2 | 0.196 |
PASK |
0.746 | 0.107 | -3 | 0.860 |
DLK |
0.746 | -0.098 | 1 | 0.487 |
CAMK2B |
0.745 | -0.026 | 2 | 0.758 |
RIPK1 |
0.745 | -0.071 | 1 | 0.468 |
PIM2 |
0.745 | 0.026 | -3 | 0.762 |
ULK1 |
0.744 | -0.159 | -3 | 0.790 |
GSK3B |
0.744 | 0.102 | 4 | 0.584 |
IRE1 |
0.743 | -0.062 | 1 | 0.482 |
MNK2 |
0.743 | -0.068 | -2 | 0.222 |
ALK2 |
0.743 | 0.021 | -2 | 0.326 |
MLK3 |
0.743 | -0.041 | 2 | 0.687 |
PAK3 |
0.743 | -0.085 | -2 | 0.232 |
MPSK1 |
0.743 | 0.110 | 1 | 0.543 |
FAM20C |
0.742 | -0.006 | 2 | 0.582 |
CAMK4 |
0.742 | -0.091 | -3 | 0.802 |
TSSK2 |
0.742 | -0.109 | -5 | 0.885 |
MLK2 |
0.742 | -0.120 | 2 | 0.777 |
PKCG |
0.742 | -0.032 | 2 | 0.684 |
MNK1 |
0.742 | -0.043 | -2 | 0.233 |
TTBK2 |
0.742 | -0.012 | 2 | 0.661 |
PKCB |
0.742 | -0.027 | 2 | 0.684 |
ATM |
0.742 | -0.039 | 1 | 0.438 |
NIM1 |
0.741 | -0.096 | 3 | 0.745 |
PLK1 |
0.741 | -0.111 | -2 | 0.233 |
ACVR2A |
0.741 | -0.056 | -2 | 0.259 |
PRKD3 |
0.741 | -0.024 | -3 | 0.753 |
WNK3 |
0.741 | -0.180 | 1 | 0.470 |
SGK3 |
0.740 | -0.011 | -3 | 0.770 |
PAK2 |
0.740 | -0.073 | -2 | 0.241 |
ACVR2B |
0.740 | -0.040 | -2 | 0.274 |
BCKDK |
0.740 | -0.150 | -1 | 0.725 |
BMPR1A |
0.740 | 0.008 | 1 | 0.438 |
PKCA |
0.740 | -0.038 | 2 | 0.669 |
ANKRD3 |
0.739 | -0.122 | 1 | 0.493 |
QIK |
0.739 | -0.093 | -3 | 0.814 |
DNAPK |
0.739 | -0.030 | 1 | 0.411 |
CK1A2 |
0.739 | 0.097 | -3 | 0.493 |
YSK4 |
0.739 | -0.116 | 1 | 0.447 |
PINK1 |
0.738 | 0.026 | 1 | 0.674 |
CAMK1G |
0.738 | -0.017 | -3 | 0.770 |
MEKK3 |
0.737 | 0.036 | 1 | 0.474 |
TSSK1 |
0.737 | -0.091 | -3 | 0.865 |
VRK2 |
0.737 | -0.054 | 1 | 0.573 |
QSK |
0.737 | -0.060 | 4 | 0.815 |
PKR |
0.736 | -0.082 | 1 | 0.510 |
MELK |
0.736 | -0.085 | -3 | 0.802 |
MST3 |
0.736 | 0.017 | 2 | 0.785 |
PAK5 |
0.736 | -0.051 | -2 | 0.190 |
PKCZ |
0.736 | -0.066 | 2 | 0.721 |
ERK7 |
0.735 | 0.115 | 2 | 0.451 |
MEK1 |
0.735 | -0.123 | 2 | 0.818 |
PAK4 |
0.735 | -0.036 | -2 | 0.191 |
SMG1 |
0.735 | -0.080 | 1 | 0.469 |
PKCH |
0.735 | -0.058 | 2 | 0.671 |
NEK9 |
0.735 | -0.213 | 2 | 0.782 |
NUAK1 |
0.734 | -0.066 | -3 | 0.786 |
CK2A2 |
0.734 | 0.029 | 1 | 0.434 |
IRE2 |
0.734 | -0.086 | 2 | 0.706 |
AKT1 |
0.734 | -0.000 | -3 | 0.730 |
GAK |
0.733 | 0.085 | 1 | 0.536 |
BRSK1 |
0.733 | -0.062 | -3 | 0.786 |
DRAK1 |
0.733 | -0.072 | 1 | 0.432 |
PHKG1 |
0.732 | -0.087 | -3 | 0.819 |
MARK3 |
0.732 | -0.069 | 4 | 0.773 |
SIK |
0.731 | -0.064 | -3 | 0.757 |
AKT3 |
0.730 | 0.023 | -3 | 0.669 |
CK2A1 |
0.730 | 0.032 | 1 | 0.422 |
SMMLCK |
0.730 | -0.033 | -3 | 0.816 |
MEK5 |
0.730 | -0.086 | 2 | 0.786 |
MAPKAPK5 |
0.730 | -0.077 | -3 | 0.735 |
MLK4 |
0.730 | -0.088 | 2 | 0.671 |
TLK2 |
0.729 | -0.118 | 1 | 0.464 |
TLK1 |
0.729 | -0.043 | -2 | 0.316 |
DCAMKL1 |
0.729 | -0.055 | -3 | 0.785 |
BRSK2 |
0.728 | -0.095 | -3 | 0.801 |
CHAK1 |
0.728 | -0.143 | 2 | 0.725 |
CK1G1 |
0.728 | 0.036 | -3 | 0.527 |
P70S6K |
0.727 | -0.023 | -3 | 0.724 |
SGK1 |
0.727 | 0.036 | -3 | 0.648 |
PLK4 |
0.727 | -0.112 | 2 | 0.634 |
PLK3 |
0.727 | -0.122 | 2 | 0.750 |
SNRK |
0.726 | -0.136 | 2 | 0.649 |
PKCE |
0.726 | -0.008 | 2 | 0.668 |
TAO3 |
0.726 | -0.027 | 1 | 0.492 |
MEKK2 |
0.726 | -0.055 | 2 | 0.763 |
ZAK |
0.725 | -0.100 | 1 | 0.446 |
WNK4 |
0.725 | -0.112 | -2 | 0.265 |
MARK2 |
0.725 | -0.092 | 4 | 0.736 |
NEK2 |
0.724 | -0.186 | 2 | 0.750 |
SSTK |
0.724 | -0.079 | 4 | 0.816 |
DAPK1 |
0.724 | -0.007 | -3 | 0.791 |
PKCI |
0.724 | -0.064 | 2 | 0.680 |
PERK |
0.724 | -0.106 | -2 | 0.291 |
MRCKA |
0.723 | -0.006 | -3 | 0.756 |
DAPK3 |
0.723 | -0.026 | -3 | 0.802 |
MARK1 |
0.723 | -0.100 | 4 | 0.788 |
CHK1 |
0.722 | -0.122 | -3 | 0.803 |
PKCT |
0.722 | -0.072 | 2 | 0.679 |
GCK |
0.721 | 0.001 | 1 | 0.482 |
MRCKB |
0.721 | -0.005 | -3 | 0.743 |
IRAK4 |
0.721 | -0.119 | 1 | 0.453 |
BRAF |
0.721 | -0.113 | -4 | 0.768 |
HRI |
0.721 | -0.164 | -2 | 0.252 |
NEK11 |
0.720 | -0.048 | 1 | 0.476 |
DMPK1 |
0.720 | 0.032 | -3 | 0.763 |
LKB1 |
0.720 | -0.051 | -3 | 0.822 |
CAMK1D |
0.719 | -0.035 | -3 | 0.692 |
SBK |
0.719 | 0.072 | -3 | 0.611 |
HPK1 |
0.719 | -0.017 | 1 | 0.476 |
DCAMKL2 |
0.719 | -0.078 | -3 | 0.799 |
ROCK2 |
0.718 | -0.003 | -3 | 0.790 |
MEKK1 |
0.717 | -0.156 | 1 | 0.469 |
CAMKK1 |
0.717 | -0.168 | -2 | 0.240 |
NEK5 |
0.716 | -0.163 | 1 | 0.471 |
PKG1 |
0.715 | -0.052 | -2 | 0.186 |
NEK8 |
0.715 | -0.122 | 2 | 0.762 |
PDK1 |
0.714 | -0.073 | 1 | 0.478 |
CAMKK2 |
0.714 | -0.149 | -2 | 0.226 |
TAO2 |
0.714 | -0.088 | 2 | 0.796 |
PHKG2 |
0.714 | -0.125 | -3 | 0.782 |
TAK1 |
0.714 | -0.035 | 1 | 0.466 |
TTBK1 |
0.713 | -0.080 | 2 | 0.588 |
LRRK2 |
0.713 | -0.055 | 2 | 0.788 |
CK1A |
0.712 | 0.103 | -3 | 0.405 |
PKN1 |
0.712 | -0.051 | -3 | 0.738 |
BUB1 |
0.711 | -0.022 | -5 | 0.820 |
CHK2 |
0.711 | -0.011 | -3 | 0.659 |
MST2 |
0.711 | -0.092 | 1 | 0.461 |
KHS2 |
0.710 | -0.010 | 1 | 0.479 |
MINK |
0.710 | -0.084 | 1 | 0.453 |
STK33 |
0.710 | -0.093 | 2 | 0.583 |
SLK |
0.709 | -0.087 | -2 | 0.229 |
TNIK |
0.709 | -0.061 | 3 | 0.851 |
HASPIN |
0.709 | 0.026 | -1 | 0.660 |
PBK |
0.709 | -0.039 | 1 | 0.482 |
HGK |
0.709 | -0.100 | 3 | 0.856 |
EEF2K |
0.708 | -0.070 | 3 | 0.832 |
MEKK6 |
0.708 | -0.110 | 1 | 0.473 |
LOK |
0.708 | -0.115 | -2 | 0.219 |
MAP3K15 |
0.708 | -0.093 | 1 | 0.448 |
CRIK |
0.706 | 0.020 | -3 | 0.738 |
CAMK1A |
0.706 | -0.034 | -3 | 0.671 |
PDHK3_TYR |
0.706 | 0.126 | 4 | 0.909 |
KHS1 |
0.706 | -0.057 | 1 | 0.460 |
ROCK1 |
0.705 | -0.017 | -3 | 0.754 |
IRAK1 |
0.705 | -0.190 | -1 | 0.689 |
NEK4 |
0.704 | -0.175 | 1 | 0.448 |
PLK2 |
0.704 | -0.061 | -3 | 0.702 |
VRK1 |
0.704 | -0.134 | 2 | 0.829 |
MST1 |
0.703 | -0.101 | 1 | 0.451 |
PDHK4_TYR |
0.702 | 0.126 | 2 | 0.845 |
BMPR2_TYR |
0.700 | 0.116 | -1 | 0.867 |
RIPK2 |
0.699 | -0.176 | 1 | 0.411 |
MAP2K6_TYR |
0.699 | 0.087 | -1 | 0.851 |
TESK1_TYR |
0.698 | 0.032 | 3 | 0.864 |
NEK1 |
0.696 | -0.196 | 1 | 0.450 |
YSK1 |
0.696 | -0.134 | 2 | 0.742 |
OSR1 |
0.696 | -0.058 | 2 | 0.749 |
YANK3 |
0.696 | -0.027 | 2 | 0.380 |
MAP2K4_TYR |
0.695 | 0.011 | -1 | 0.843 |
PDHK1_TYR |
0.695 | 0.064 | -1 | 0.880 |
TTK |
0.695 | -0.063 | -2 | 0.279 |
PKMYT1_TYR |
0.694 | 0.051 | 3 | 0.826 |
LIMK2_TYR |
0.693 | 0.011 | -3 | 0.866 |
ALPHAK3 |
0.691 | 0.004 | -1 | 0.763 |
BIKE |
0.691 | -0.047 | 1 | 0.473 |
MAP2K7_TYR |
0.691 | -0.088 | 2 | 0.826 |
MEK2 |
0.691 | -0.240 | 2 | 0.783 |
CK1G2 |
0.689 | 0.128 | -3 | 0.446 |
PINK1_TYR |
0.688 | -0.098 | 1 | 0.536 |
MYO3B |
0.687 | -0.104 | 2 | 0.758 |
MYO3A |
0.686 | -0.097 | 1 | 0.474 |
NEK3 |
0.683 | -0.201 | 1 | 0.442 |
ASK1 |
0.683 | -0.138 | 1 | 0.443 |
LIMK1_TYR |
0.682 | -0.091 | 2 | 0.808 |
EPHA6 |
0.681 | -0.039 | -1 | 0.858 |
TAO1 |
0.681 | -0.127 | 1 | 0.432 |
CK1G3 |
0.681 | 0.063 | -3 | 0.358 |
AAK1 |
0.680 | -0.023 | 1 | 0.435 |
FGR |
0.680 | -0.028 | 1 | 0.473 |
RET |
0.677 | -0.156 | 1 | 0.479 |
TXK |
0.676 | -0.006 | 1 | 0.461 |
MST1R |
0.674 | -0.107 | 3 | 0.759 |
JAK3 |
0.674 | -0.076 | 1 | 0.465 |
YES1 |
0.673 | -0.061 | -1 | 0.827 |
DDR1 |
0.673 | -0.137 | 4 | 0.852 |
STLK3 |
0.673 | -0.155 | 1 | 0.425 |
EPHB4 |
0.672 | -0.104 | -1 | 0.807 |
FYN |
0.671 | 0.039 | -1 | 0.848 |
LCK |
0.671 | -0.012 | -1 | 0.846 |
FGFR2 |
0.671 | -0.047 | 3 | 0.762 |
CSF1R |
0.670 | -0.106 | 3 | 0.741 |
JAK2 |
0.670 | -0.169 | 1 | 0.472 |
SYK |
0.670 | 0.124 | -1 | 0.820 |
BLK |
0.670 | 0.003 | -1 | 0.859 |
ABL2 |
0.669 | -0.091 | -1 | 0.790 |
INSRR |
0.669 | -0.076 | 3 | 0.704 |
TYK2 |
0.669 | -0.238 | 1 | 0.463 |
ROS1 |
0.669 | -0.151 | 3 | 0.728 |
KDR |
0.669 | -0.054 | 3 | 0.706 |
EPHA4 |
0.668 | -0.058 | 2 | 0.757 |
YANK2 |
0.668 | -0.035 | 2 | 0.391 |
TYRO3 |
0.668 | -0.175 | 3 | 0.761 |
HCK |
0.667 | -0.078 | -1 | 0.834 |
NEK10_TYR |
0.667 | -0.144 | 1 | 0.438 |
FLT1 |
0.667 | -0.028 | -1 | 0.836 |
MET |
0.666 | -0.004 | 3 | 0.731 |
WEE1_TYR |
0.666 | -0.048 | -1 | 0.699 |
KIT |
0.666 | -0.086 | 3 | 0.751 |
ABL1 |
0.666 | -0.102 | -1 | 0.777 |
FER |
0.666 | -0.130 | 1 | 0.472 |
ITK |
0.665 | -0.084 | -1 | 0.779 |
TEK |
0.664 | -0.060 | 3 | 0.700 |
SRMS |
0.664 | -0.106 | 1 | 0.453 |
TNK2 |
0.664 | -0.100 | 3 | 0.703 |
PTK2 |
0.663 | 0.050 | -1 | 0.822 |
FGFR3 |
0.663 | -0.031 | 3 | 0.728 |
ERBB2 |
0.662 | -0.052 | 1 | 0.434 |
TNNI3K_TYR |
0.662 | -0.103 | 1 | 0.484 |
FGFR1 |
0.662 | -0.088 | 3 | 0.716 |
BMX |
0.662 | -0.063 | -1 | 0.714 |
EPHB1 |
0.661 | -0.140 | 1 | 0.445 |
TNK1 |
0.661 | -0.136 | 3 | 0.739 |
FLT3 |
0.660 | -0.151 | 3 | 0.757 |
EPHB2 |
0.659 | -0.110 | -1 | 0.794 |
JAK1 |
0.659 | -0.138 | 1 | 0.423 |
DDR2 |
0.659 | -0.073 | 3 | 0.690 |
EPHB3 |
0.658 | -0.145 | -1 | 0.791 |
SRC |
0.657 | -0.018 | -1 | 0.824 |
FRK |
0.656 | -0.078 | -1 | 0.849 |
TEC |
0.656 | -0.095 | -1 | 0.715 |
PDGFRB |
0.656 | -0.204 | 3 | 0.759 |
EGFR |
0.656 | -0.046 | 1 | 0.373 |
MERTK |
0.654 | -0.144 | 3 | 0.725 |
EPHA3 |
0.654 | -0.110 | 2 | 0.728 |
LYN |
0.653 | -0.075 | 3 | 0.677 |
ZAP70 |
0.653 | 0.078 | -1 | 0.719 |
EPHA7 |
0.653 | -0.111 | 2 | 0.749 |
ERBB4 |
0.653 | 0.014 | 1 | 0.384 |
FLT4 |
0.653 | -0.118 | 3 | 0.714 |
BTK |
0.652 | -0.173 | -1 | 0.728 |
MATK |
0.652 | -0.070 | -1 | 0.719 |
AXL |
0.651 | -0.187 | 3 | 0.727 |
PDGFRA |
0.650 | -0.227 | 3 | 0.757 |
PTK2B |
0.649 | -0.082 | -1 | 0.738 |
EPHA8 |
0.649 | -0.070 | -1 | 0.808 |
ALK |
0.649 | -0.164 | 3 | 0.664 |
LTK |
0.647 | -0.177 | 3 | 0.688 |
EPHA5 |
0.647 | -0.101 | 2 | 0.746 |
FGFR4 |
0.646 | -0.076 | -1 | 0.750 |
PTK6 |
0.646 | -0.206 | -1 | 0.678 |
NTRK1 |
0.646 | -0.207 | -1 | 0.780 |
INSR |
0.644 | -0.155 | 3 | 0.679 |
EPHA1 |
0.644 | -0.177 | 3 | 0.705 |
NTRK3 |
0.643 | -0.144 | -1 | 0.733 |
NTRK2 |
0.643 | -0.212 | 3 | 0.708 |
CSK |
0.640 | -0.153 | 2 | 0.754 |
EPHA2 |
0.639 | -0.094 | -1 | 0.772 |
MUSK |
0.639 | -0.130 | 1 | 0.374 |
IGF1R |
0.636 | -0.113 | 3 | 0.626 |
FES |
0.622 | -0.117 | -1 | 0.682 |