Motif 512 (n=104)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WV96 | CYP3A7-CYP3A51P | S139 | ochoa | Cytochrome P450 3A (EC 1.14.14.-) | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. {ECO:0000256|RuleBase:RU368049}. |
| A3KN83 | SBNO1 | S817 | ochoa | Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) | Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250|UniProtKB:Q689Z5}. |
| A5YKK6 | CNOT1 | S1008 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| A6NKT7 | RGPD3 | S1481 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H7BY64 | ZNF511-PRAP1 | S151 | ochoa | ZNF511-PRAP1 readthrough | None |
| M0R2C6 | None | S196 | ochoa | serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase) | None |
| O14654 | IRS4 | S1107 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14715 | RGPD8 | S1480 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43609 | SPRY1 | S50 | ochoa | Protein sprouty homolog 1 (Spry-1) | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9QXV9}. |
| O75044 | SRGAP2 | S427 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75150 | RNF40 | S528 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75410 | TACC1 | S228 | psp | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O94953 | KDM4B | S1041 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| P08684 | CYP3A4 | S139 | ochoa | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P08708 | RPS17 | S115 | ochoa | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P0DJD0 | RGPD1 | S1465 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1473 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DJJ0 | SRGAP2C | S427 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1) | Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}. |
| P0DMP2 | SRGAP2B | S426 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2) | May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). {ECO:0000269|PubMed:31822692, ECO:0000305|PubMed:22559944, ECO:0000305|PubMed:31822692}. |
| P10809 | HSPD1 | S252 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P20815 | CYP3A5 | S139 | ochoa | Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:2732228}. |
| P21333 | FLNA | S204 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23193 | TCEA1 | S137 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P24462 | CYP3A7 | S139 | ochoa | Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:17178770, PubMed:9555064). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:12865317, PubMed:14559847). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:17178770, ECO:0000269|PubMed:9555064}. |
| P24534 | EEF1B2 | S141 | ochoa | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
| P29374 | ARID4A | S673 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P29966 | MARCKS | S52 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P35222 | CTNNB1 | S680 | ochoa | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35269 | GTF2F1 | S391 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P38159 | RBMX | S249 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38398 | BRCA1 | S1460 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P48634 | PRRC2A | S761 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49792 | RANBP2 | S2456 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51153 | RAB13 | S178 | ochoa | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
| P52272 | HNRNPM | S452 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P57078 | RIPK4 | S359 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P60891 | PRPS1 | S285 | psp | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P61018 | RAB4B | S193 | ochoa | Ras-related protein Rab-4B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed:20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:Q91ZR1, ECO:0000269|PubMed:20534812}. |
| P63244 | RACK1 | S276 | ochoa | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
| Q01826 | SATB1 | S465 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q03188 | CENPC | S168 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03252 | LMNB2 | S553 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q04637 | EIF4G1 | S1098 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q04637 | EIF4G1 | S1194 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q10586 | DBP | S159 | ochoa | D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) | This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. |
| Q12767 | TMEM94 | S454 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12893 | TMEM115 | S266 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
| Q13428 | TCOF1 | S227 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S375 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14204 | DYNC1H1 | S4370 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14207 | NPAT | S377 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q15398 | DLGAP5 | S720 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15642 | TRIP10 | S482 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q16825 | PTPN21 | S616 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q16891 | IMMT | S192 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2KJY2 | KIF26B | S1144 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q5T1R4 | HIVEP3 | S1019 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5VSL9 | STRIP1 | S59 | ochoa | Striatin-interacting protein 1 (Protein FAM40A) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}. |
| Q6DN90 | IQSEC1 | S262 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6DT37 | CDC42BPG | S1514 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q7Z3J3 | RGPD4 | S1481 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z403 | TMC6 | S63 | ochoa | Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:30068544, PubMed:32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q7TN60, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q7Z5J4 | RAI1 | S683 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6B7 | SRGAP1 | S416 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q8IX01 | SUGP2 | S572 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IX03 | WWC1 | S150 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IXJ6 | SIRT2 | S366 | ochoa | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24177535, PubMed:24681946, PubMed:24769394, PubMed:24940000). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24177535, PubMed:24681946, PubMed:24769394, PubMed:24940000). Plays a major role in the control of cell cycle progression and genomic stability (PubMed:12697818, PubMed:16909107, PubMed:17488717, PubMed:17726514, PubMed:19282667, PubMed:23468428). Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes (PubMed:12697818, PubMed:16909107, PubMed:17488717, PubMed:17726514, PubMed:19282667, PubMed:23468428). Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis (PubMed:22014574). Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes (PubMed:23468428). Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis (PubMed:23468428). Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression (PubMed:23468428). Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response (PubMed:23468428). Also deacetylates histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition (PubMed:20587414). Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection (PubMed:23908241). During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function (PubMed:24940000). Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis (PubMed:24940000). Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells (PubMed:18332217, PubMed:18995842). Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation (PubMed:17488717). Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination (PubMed:21949390). Involved in several cellular metabolic pathways (PubMed:20543840, PubMed:21726808, PubMed:24769394). Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability (PubMed:21726808). Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage (PubMed:24769394). Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis (PubMed:20543840). Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity (PubMed:20543840). Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells (PubMed:20543840). Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (PubMed:20543840). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia (PubMed:24681946). Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation (PubMed:21081649). Inhibits transcriptional activation by deacetylating p53/TP53 and EP300 (PubMed:18249187, PubMed:18995842). Also deacetylates EIF5A (PubMed:22771473). Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions (PubMed:24769394). Plays a role as tumor suppressor (PubMed:22014574). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes (PubMed:25704306, PubMed:29239724, PubMed:32103017). {ECO:0000250|UniProtKB:Q8VDQ8, ECO:0000269|PubMed:12620231, ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17574768, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:18249187, ECO:0000269|PubMed:18332217, ECO:0000269|PubMed:18640115, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:19282667, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:20587414, ECO:0000269|PubMed:21081649, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:21949390, ECO:0000269|PubMed:22014574, ECO:0000269|PubMed:22771473, ECO:0000269|PubMed:22819792, ECO:0000269|PubMed:23468428, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:24177535, ECO:0000269|PubMed:24681946, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25704306, ECO:0000269|PubMed:29239724, ECO:0000269|PubMed:32103017}.; FUNCTION: [Isoform 1]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 2]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 5]: Lacks deacetylation activity, at least toward known SIRT2 targets. {ECO:0000269|PubMed:24177535}. |
| Q8N3D4 | EHBP1L1 | S239 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8NB15 | ZNF511 | S208 | ochoa | Zinc finger protein 511 | May be involved in transcriptional regulation. {ECO:0000305}. |
| Q8NHV4 | NEDD1 | S338 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TC90 | CCER1 | S230 | ochoa | Coiled-coil domain-containing glutamate-rich protein 1 | Regulator of histone epigenetic modifications and chromatin compaction into the sperm head, required for histone-to-protamine (HTP) transition. HTP is a key event in which somatic histones are first replaced by testis-specific histone variants, then transition proteins (TNPs) are incorporated into the spermatid nucleus, and finally protamines (PRMs) replace the TNPs to promote chromatin condensation. {ECO:0000250|UniProtKB:Q9CQL2}. |
| Q8TD55 | PLEKHO2 | S433 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TEW0 | PARD3 | S803 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WUA7 | TBC1D22A | S145 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q8WXI7 | MUC16 | S6969 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q92854 | SEMA4D | S800 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q96B33 | CLDN23 | S206 | ochoa | Claudin-23 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S249 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96EA4 | SPDL1 | S546 | ochoa | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}. |
| Q96RL1 | UIMC1 | S410 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96TC7 | RMDN3 | S233 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99666 | RGPD5 | S1480 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BVA0 | KATNB1 | S400 | ochoa | Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:10751153}. |
| Q9H8Y8 | GORASP2 | S432 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9NP81 | SARS2 | S126 | ochoa | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}. |
| Q9NR09 | BIRC6 | S797 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NXX6 | NSMCE4A | S63 | ochoa | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}. |
| Q9NYF8 | BCLAF1 | S525 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P0Z9 | PIPOX | S300 | ochoa | Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) | Metabolizes sarcosine and L-pipecolic acid. {ECO:0000269|PubMed:10642506}. |
| Q9UBE0 | SAE1 | S185 | ochoa | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
| Q9UBP0 | SPAST | S92 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
| Q9UHC7 | MKRN1 | S133 | ochoa | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}. |
| Q9UNZ2 | NSFL1C | S60 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9Y2H5 | PLEKHA6 | S961 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y4F5 | CEP170B | S1362 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y597 | KCTD3 | S602 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y6M5 | SLC30A1 | S199 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y5X1 | SNX9 | S122 | Sugiyama | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| O75676 | RPS6KA4 | S396 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| P47224 | RABIF | S39 | Sugiyama | Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) | Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein (PubMed:31540829). Might play a general role in vesicular transport. {ECO:0000269|PubMed:31540829}. |
| Q13526 | PIN1 | S126 | Sugiyama | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q12851 | MAP4K2 | S475 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q99627 | COPS8 | S157 | Sugiyama | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q9HBH9 | MKNK2 | S431 | Sugiyama | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.000091 | 4.040 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.000132 | 3.878 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000378 | 3.423 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.001075 | 2.969 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.001897 | 2.722 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.002808 | 2.552 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.002909 | 2.536 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.004514 | 2.345 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.004514 | 2.345 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.004858 | 2.314 |
| R-HSA-68882 | Mitotic Anaphase | 0.006609 | 2.180 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.006741 | 2.171 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.008019 | 2.096 |
| R-HSA-68886 | M Phase | 0.007723 | 2.112 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.007536 | 2.123 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.010739 | 1.969 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.012006 | 1.921 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.013937 | 1.856 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.013937 | 1.856 |
| R-HSA-211981 | Xenobiotics | 0.014531 | 1.838 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.013975 | 1.855 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.016839 | 1.774 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.016179 | 1.791 |
| R-HSA-68877 | Mitotic Prometaphase | 0.017239 | 1.763 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.015455 | 1.811 |
| R-HSA-429947 | Deadenylation of mRNA | 0.019156 | 1.718 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.022867 | 1.641 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.022867 | 1.641 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.024164 | 1.617 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.024164 | 1.617 |
| R-HSA-420029 | Tight junction interactions | 0.020362 | 1.691 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.021599 | 1.666 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.022867 | 1.641 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.021599 | 1.666 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.020560 | 1.687 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.054605 | 1.263 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.067788 | 1.169 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.067788 | 1.169 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 0.080789 | 1.093 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.080789 | 1.093 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.093610 | 1.029 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.099954 | 1.000 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.099954 | 1.000 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.106253 | 0.974 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.106253 | 0.974 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.106253 | 0.974 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.106253 | 0.974 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.106253 | 0.974 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.106253 | 0.974 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.124892 | 0.903 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.124892 | 0.903 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.131019 | 0.883 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.131019 | 0.883 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.143145 | 0.844 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.043555 | 1.361 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.155104 | 0.809 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.155104 | 0.809 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.161021 | 0.793 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.161021 | 0.793 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.161021 | 0.793 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.161021 | 0.793 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.184281 | 0.735 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.184281 | 0.735 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.184281 | 0.735 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.066981 | 1.174 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.068925 | 1.162 |
| R-HSA-72649 | Translation initiation complex formation | 0.070888 | 1.149 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.195671 | 0.708 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.074868 | 1.126 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.212460 | 0.673 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.212460 | 0.673 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.217979 | 0.662 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.089331 | 1.049 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.089331 | 1.049 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.223460 | 0.651 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.095763 | 1.019 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.228902 | 0.640 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.228902 | 0.640 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.239674 | 0.620 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.239674 | 0.620 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.245004 | 0.611 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.111259 | 0.954 |
| R-HSA-380287 | Centrosome maturation | 0.115800 | 0.936 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.255552 | 0.593 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.148783 | 0.827 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.158530 | 0.800 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.206190 | 0.686 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.216429 | 0.665 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.216429 | 0.665 |
| R-HSA-167172 | Transcription of the HIV genome | 0.100124 | 0.999 |
| R-HSA-72172 | mRNA Splicing | 0.208624 | 0.681 |
| R-HSA-167169 | HIV Transcription Elongation | 0.043555 | 1.361 |
| R-HSA-72086 | mRNA Capping | 0.217979 | 0.662 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.188971 | 0.724 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.153641 | 0.813 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.043555 | 1.361 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.078918 | 1.103 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.159404 | 0.798 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.047945 | 1.319 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.087222 | 1.059 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.041908 | 1.378 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.265955 | 0.575 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.250296 | 0.602 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.115800 | 0.936 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.155104 | 0.809 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.231871 | 0.635 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.129697 | 0.887 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.195671 | 0.708 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.041237 | 1.385 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.239674 | 0.620 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.160986 | 0.793 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.231871 | 0.635 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.113524 | 0.945 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.221567 | 0.654 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.245004 | 0.611 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.103309 | 0.986 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.239674 | 0.620 |
| R-HSA-525793 | Myogenesis | 0.201306 | 0.696 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.239674 | 0.620 |
| R-HSA-5693538 | Homology Directed Repair | 0.237035 | 0.625 |
| R-HSA-8875656 | MET receptor recycling | 0.074311 | 1.129 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.155104 | 0.809 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.076884 | 1.114 |
| R-HSA-8949613 | Cristae formation | 0.206903 | 0.684 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.085118 | 1.070 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.250296 | 0.602 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.260772 | 0.584 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.265955 | 0.575 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.119574 | 0.922 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.161021 | 0.793 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.055724 | 1.254 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.245004 | 0.611 |
| R-HSA-4641258 | Degradation of DVL | 0.265955 | 0.575 |
| R-HSA-162587 | HIV Life Cycle | 0.125711 | 0.901 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.080968 | 1.092 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.083035 | 1.081 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.245004 | 0.611 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.104749 | 0.980 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.172732 | 0.763 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.198547 | 0.702 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.122628 | 0.911 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.112510 | 0.949 |
| R-HSA-9754706 | Atorvastatin ADME | 0.131019 | 0.883 |
| R-HSA-9834899 | Specification of the neural plate border | 0.155104 | 0.809 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.250296 | 0.602 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.136786 | 0.864 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.173365 | 0.761 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.206190 | 0.686 |
| R-HSA-9609690 | HCMV Early Events | 0.192508 | 0.716 |
| R-HSA-162906 | HIV Infection | 0.251031 | 0.600 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.234307 | 0.630 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.206903 | 0.684 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.217979 | 0.662 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.250296 | 0.602 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.255552 | 0.593 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.239674 | 0.620 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.112510 | 0.949 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.113524 | 0.945 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.039902 | 1.399 |
| R-HSA-416700 | Other semaphorin interactions | 0.124892 | 0.903 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.127354 | 0.895 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.054605 | 1.263 |
| R-HSA-9766229 | Degradation of CDH1 | 0.061263 | 1.213 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.206903 | 0.684 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.245004 | 0.611 |
| R-HSA-73894 | DNA Repair | 0.129811 | 0.887 |
| R-HSA-182971 | EGFR downregulation | 0.228902 | 0.640 |
| R-HSA-421270 | Cell-cell junction organization | 0.123982 | 0.907 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.072549 | 1.139 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.045225 | 1.345 |
| R-HSA-446728 | Cell junction organization | 0.059496 | 1.226 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.161021 | 0.793 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.228902 | 0.640 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.172732 | 0.763 |
| R-HSA-1500931 | Cell-Cell communication | 0.088535 | 1.053 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.047945 | 1.319 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.137103 | 0.863 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.137103 | 0.863 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.172732 | 0.763 |
| R-HSA-199991 | Membrane Trafficking | 0.190838 | 0.719 |
| R-HSA-168255 | Influenza Infection | 0.163038 | 0.788 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.112510 | 0.949 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.178527 | 0.748 |
| R-HSA-69481 | G2/M Checkpoints | 0.262931 | 0.580 |
| R-HSA-3214842 | HDMs demethylate histones | 0.195671 | 0.708 |
| R-HSA-68875 | Mitotic Prophase | 0.242206 | 0.616 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.143958 | 0.842 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.080789 | 1.093 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.106253 | 0.974 |
| R-HSA-9830364 | Formation of the nephric duct | 0.195671 | 0.708 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.074311 | 1.129 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.124892 | 0.903 |
| R-HSA-1640170 | Cell Cycle | 0.032707 | 1.485 |
| R-HSA-392499 | Metabolism of proteins | 0.254248 | 0.595 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.093460 | 1.029 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.127354 | 0.895 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.055090 | 1.259 |
| R-HSA-435354 | Zinc transporters | 0.118722 | 0.925 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.059396 | 1.226 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.184281 | 0.735 |
| R-HSA-9733709 | Cardiogenesis | 0.239674 | 0.620 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.178527 | 0.748 |
| R-HSA-9757110 | Prednisone ADME | 0.212460 | 0.673 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.239674 | 0.620 |
| R-HSA-8983711 | OAS antiviral response | 0.106253 | 0.974 |
| R-HSA-71064 | Lysine catabolism | 0.265955 | 0.575 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.115047 | 0.939 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.041908 | 1.378 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.225033 | 0.648 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.260772 | 0.584 |
| R-HSA-422475 | Axon guidance | 0.104009 | 0.983 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.029645 | 1.528 |
| R-HSA-9675108 | Nervous system development | 0.132211 | 0.879 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.141535 | 0.849 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.052136 | 1.283 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.203639 | 0.691 |
| R-HSA-162582 | Signal Transduction | 0.029484 | 1.530 |
| R-HSA-9909396 | Circadian clock | 0.086679 | 1.062 |
| R-HSA-75153 | Apoptotic execution phase | 0.055724 | 1.254 |
| R-HSA-2028269 | Signaling by Hippo | 0.143145 | 0.844 |
| R-HSA-913531 | Interferon Signaling | 0.155454 | 0.808 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.203639 | 0.691 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.055745 | 1.254 |
| R-HSA-190236 | Signaling by FGFR | 0.178359 | 0.749 |
| R-HSA-157118 | Signaling by NOTCH | 0.111107 | 0.954 |
| R-HSA-8939211 | ESR-mediated signaling | 0.269872 | 0.569 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.271102 | 0.567 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.271102 | 0.567 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.276214 | 0.559 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.276214 | 0.559 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.276214 | 0.559 |
| R-HSA-71336 | Pentose phosphate pathway | 0.276214 | 0.559 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.276214 | 0.559 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.278488 | 0.555 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.281289 | 0.551 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.281289 | 0.551 |
| R-HSA-9646399 | Aggrephagy | 0.281289 | 0.551 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.281289 | 0.551 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.281289 | 0.551 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.281289 | 0.551 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.286330 | 0.543 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.286330 | 0.543 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.286330 | 0.543 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.286457 | 0.543 |
| R-HSA-597592 | Post-translational protein modification | 0.289213 | 0.539 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.291336 | 0.536 |
| R-HSA-167161 | HIV Transcription Initiation | 0.291336 | 0.536 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.291336 | 0.536 |
| R-HSA-9609646 | HCMV Infection | 0.294595 | 0.531 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.296306 | 0.528 |
| R-HSA-165159 | MTOR signalling | 0.296306 | 0.528 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.301243 | 0.521 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.311012 | 0.507 |
| R-HSA-774815 | Nucleosome assembly | 0.311012 | 0.507 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.311012 | 0.507 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.311012 | 0.507 |
| R-HSA-9824272 | Somitogenesis | 0.311012 | 0.507 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.311012 | 0.507 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.315846 | 0.501 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.315846 | 0.501 |
| R-HSA-9675135 | Diseases of DNA repair | 0.315846 | 0.501 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.315846 | 0.501 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.315846 | 0.501 |
| R-HSA-437239 | Recycling pathway of L1 | 0.320646 | 0.494 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.322385 | 0.492 |
| R-HSA-425410 | Metal ion SLC transporters | 0.325413 | 0.488 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.334848 | 0.475 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.335190 | 0.475 |
| R-HSA-9609507 | Protein localization | 0.337743 | 0.471 |
| R-HSA-912446 | Meiotic recombination | 0.339516 | 0.469 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.344152 | 0.463 |
| R-HSA-9610379 | HCMV Late Events | 0.347926 | 0.459 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.348206 | 0.458 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.348755 | 0.457 |
| R-HSA-1221632 | Meiotic synapsis | 0.348755 | 0.457 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.348755 | 0.457 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.353327 | 0.452 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.355530 | 0.449 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.357866 | 0.446 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.357866 | 0.446 |
| R-HSA-109581 | Apoptosis | 0.360583 | 0.443 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.362374 | 0.441 |
| R-HSA-177929 | Signaling by EGFR | 0.362374 | 0.441 |
| R-HSA-75893 | TNF signaling | 0.362374 | 0.441 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.363567 | 0.439 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.366851 | 0.436 |
| R-HSA-5621480 | Dectin-2 family | 0.366851 | 0.436 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.366851 | 0.436 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.371296 | 0.430 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.371296 | 0.430 |
| R-HSA-191859 | snRNP Assembly | 0.375711 | 0.425 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.375711 | 0.425 |
| R-HSA-9033241 | Peroxisomal protein import | 0.375711 | 0.425 |
| R-HSA-983189 | Kinesins | 0.380095 | 0.420 |
| R-HSA-379724 | tRNA Aminoacylation | 0.380095 | 0.420 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.384448 | 0.415 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.384448 | 0.415 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.384448 | 0.415 |
| R-HSA-72766 | Translation | 0.388562 | 0.411 |
| R-HSA-1268020 | Mitochondrial protein import | 0.388771 | 0.410 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.388771 | 0.410 |
| R-HSA-9707616 | Heme signaling | 0.388771 | 0.410 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.388771 | 0.410 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.390578 | 0.408 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.390578 | 0.408 |
| R-HSA-373755 | Semaphorin interactions | 0.393064 | 0.406 |
| R-HSA-8953854 | Metabolism of RNA | 0.394785 | 0.404 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.397327 | 0.401 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.401560 | 0.396 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.405764 | 0.392 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.409939 | 0.387 |
| R-HSA-9830369 | Kidney development | 0.409939 | 0.387 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.414084 | 0.383 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.414084 | 0.383 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.415098 | 0.382 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.422289 | 0.374 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.422289 | 0.374 |
| R-HSA-69275 | G2/M Transition | 0.422360 | 0.374 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.426348 | 0.370 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.426348 | 0.370 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.427176 | 0.369 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.427676 | 0.369 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.430380 | 0.366 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.430380 | 0.366 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.430380 | 0.366 |
| R-HSA-5617833 | Cilium Assembly | 0.431972 | 0.365 |
| R-HSA-6798695 | Neutrophil degranulation | 0.432788 | 0.364 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.434383 | 0.362 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.434383 | 0.362 |
| R-HSA-4086398 | Ca2+ pathway | 0.434383 | 0.362 |
| R-HSA-9749641 | Aspirin ADME | 0.434383 | 0.362 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.438358 | 0.358 |
| R-HSA-8852135 | Protein ubiquitination | 0.442306 | 0.354 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.446231 | 0.350 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.455627 | 0.341 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.460292 | 0.337 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.461635 | 0.336 |
| R-HSA-6806834 | Signaling by MET | 0.461635 | 0.336 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.465420 | 0.332 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.469179 | 0.329 |
| R-HSA-5357801 | Programmed Cell Death | 0.469551 | 0.328 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.476619 | 0.322 |
| R-HSA-1500620 | Meiosis | 0.480300 | 0.318 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.483955 | 0.315 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.487585 | 0.312 |
| R-HSA-156902 | Peptide chain elongation | 0.494769 | 0.306 |
| R-HSA-9663891 | Selective autophagy | 0.494769 | 0.306 |
| R-HSA-418990 | Adherens junctions interactions | 0.498988 | 0.302 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.505358 | 0.296 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.505376 | 0.296 |
| R-HSA-8951664 | Neddylation | 0.505633 | 0.296 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.519135 | 0.285 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.520919 | 0.283 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.521222 | 0.283 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.522519 | 0.282 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.522519 | 0.282 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.525880 | 0.279 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.525880 | 0.279 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.529218 | 0.276 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.532532 | 0.274 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.532532 | 0.274 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.533772 | 0.273 |
| R-HSA-422356 | Regulation of insulin secretion | 0.535823 | 0.271 |
| R-HSA-70171 | Glycolysis | 0.542336 | 0.266 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.545559 | 0.263 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.548759 | 0.261 |
| R-HSA-1483255 | PI Metabolism | 0.548759 | 0.261 |
| R-HSA-212436 | Generic Transcription Pathway | 0.551067 | 0.259 |
| R-HSA-192823 | Viral mRNA Translation | 0.551936 | 0.258 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.555092 | 0.256 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.555092 | 0.256 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.555092 | 0.256 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.564427 | 0.248 |
| R-HSA-4839726 | Chromatin organization | 0.564872 | 0.248 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.567496 | 0.246 |
| R-HSA-211000 | Gene Silencing by RNA | 0.567496 | 0.246 |
| R-HSA-5688426 | Deubiquitination | 0.576894 | 0.239 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.578256 | 0.238 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.582519 | 0.235 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.588382 | 0.230 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.597025 | 0.224 |
| R-HSA-2262752 | Cellular responses to stress | 0.598842 | 0.223 |
| R-HSA-373760 | L1CAM interactions | 0.599866 | 0.222 |
| R-HSA-70326 | Glucose metabolism | 0.602686 | 0.220 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.602686 | 0.220 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.602686 | 0.220 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.602686 | 0.220 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.608269 | 0.216 |
| R-HSA-73886 | Chromosome Maintenance | 0.613774 | 0.212 |
| R-HSA-3371556 | Cellular response to heat stress | 0.613774 | 0.212 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.619202 | 0.208 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.621888 | 0.206 |
| R-HSA-194138 | Signaling by VEGF | 0.627203 | 0.203 |
| R-HSA-114608 | Platelet degranulation | 0.632444 | 0.199 |
| R-HSA-1474165 | Reproduction | 0.642708 | 0.192 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.650219 | 0.187 |
| R-HSA-195721 | Signaling by WNT | 0.655986 | 0.183 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.659991 | 0.180 |
| R-HSA-163685 | Integration of energy metabolism | 0.659991 | 0.180 |
| R-HSA-5173105 | O-linked glycosylation | 0.662392 | 0.179 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.664775 | 0.177 |
| R-HSA-6807070 | PTEN Regulation | 0.667142 | 0.176 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.668450 | 0.175 |
| R-HSA-1632852 | Macroautophagy | 0.671826 | 0.173 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.676445 | 0.170 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.678731 | 0.168 |
| R-HSA-9758941 | Gastrulation | 0.692110 | 0.160 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.694285 | 0.158 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.696446 | 0.157 |
| R-HSA-9824446 | Viral Infection Pathways | 0.702584 | 0.153 |
| R-HSA-73887 | Death Receptor Signaling | 0.702836 | 0.153 |
| R-HSA-9612973 | Autophagy | 0.707022 | 0.151 |
| R-HSA-9711097 | Cellular response to starvation | 0.711150 | 0.148 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.715220 | 0.146 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.723190 | 0.141 |
| R-HSA-5619102 | SLC transporter disorders | 0.729023 | 0.137 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.734134 | 0.134 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.736610 | 0.133 |
| R-HSA-72306 | tRNA processing | 0.736610 | 0.133 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.738474 | 0.132 |
| R-HSA-211859 | Biological oxidations | 0.738899 | 0.131 |
| R-HSA-1266738 | Developmental Biology | 0.739773 | 0.131 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.740324 | 0.131 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.745799 | 0.127 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.745799 | 0.127 |
| R-HSA-74160 | Gene expression (Transcription) | 0.753629 | 0.123 |
| R-HSA-3781865 | Diseases of glycosylation | 0.761544 | 0.118 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.768229 | 0.115 |
| R-HSA-9679506 | SARS-CoV Infections | 0.773301 | 0.112 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.787187 | 0.104 |
| R-HSA-9748784 | Drug ADME | 0.814108 | 0.089 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.820568 | 0.086 |
| R-HSA-72312 | rRNA processing | 0.831758 | 0.080 |
| R-HSA-168249 | Innate Immune System | 0.844604 | 0.073 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.848827 | 0.071 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.850358 | 0.070 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.858233 | 0.066 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.869878 | 0.061 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.875339 | 0.058 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.882269 | 0.054 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.889300 | 0.051 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.892725 | 0.049 |
| R-HSA-1483257 | Phospholipid metabolism | 0.892725 | 0.049 |
| R-HSA-5663205 | Infectious disease | 0.922871 | 0.035 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.923408 | 0.035 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.941597 | 0.026 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.943367 | 0.025 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.946151 | 0.024 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.948798 | 0.023 |
| R-HSA-5668914 | Diseases of metabolism | 0.958759 | 0.018 |
| R-HSA-109582 | Hemostasis | 0.978865 | 0.009 |
| R-HSA-1280218 | Adaptive Immune System | 0.982338 | 0.008 |
| R-HSA-168256 | Immune System | 0.982921 | 0.007 |
| R-HSA-1643685 | Disease | 0.993901 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 0.999297 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999812 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999996 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.827 | 0.240 | 2 | 0.808 |
MOS |
0.818 | 0.300 | 1 | 0.797 |
BMPR1B |
0.817 | 0.341 | 1 | 0.862 |
CLK3 |
0.816 | 0.196 | 1 | 0.689 |
CDC7 |
0.816 | 0.174 | 1 | 0.824 |
GRK1 |
0.810 | 0.239 | -2 | 0.778 |
PIM3 |
0.806 | 0.096 | -3 | 0.800 |
SKMLCK |
0.806 | 0.152 | -2 | 0.781 |
KIS |
0.803 | 0.075 | 1 | 0.518 |
RAF1 |
0.803 | 0.012 | 1 | 0.720 |
RIPK3 |
0.802 | 0.066 | 3 | 0.757 |
SRPK1 |
0.801 | 0.126 | -3 | 0.725 |
PRPK |
0.801 | -0.046 | -1 | 0.768 |
DSTYK |
0.800 | 0.033 | 2 | 0.816 |
MST4 |
0.800 | 0.099 | 2 | 0.803 |
AURC |
0.800 | 0.106 | -2 | 0.577 |
IKKB |
0.799 | -0.063 | -2 | 0.663 |
RSK2 |
0.799 | 0.075 | -3 | 0.732 |
TGFBR2 |
0.799 | 0.030 | -2 | 0.728 |
NDR2 |
0.799 | 0.026 | -3 | 0.802 |
WNK1 |
0.799 | 0.077 | -2 | 0.790 |
CAMK1B |
0.798 | 0.027 | -3 | 0.810 |
PRKD1 |
0.797 | 0.088 | -3 | 0.786 |
NLK |
0.797 | 0.008 | 1 | 0.650 |
GRK5 |
0.797 | 0.036 | -3 | 0.828 |
ERK5 |
0.797 | 0.030 | 1 | 0.674 |
NUAK2 |
0.796 | 0.070 | -3 | 0.792 |
CLK2 |
0.796 | 0.186 | -3 | 0.716 |
BMPR2 |
0.796 | -0.008 | -2 | 0.773 |
CDKL1 |
0.795 | 0.037 | -3 | 0.760 |
PRKD2 |
0.795 | 0.081 | -3 | 0.726 |
PKN2 |
0.795 | 0.064 | -3 | 0.784 |
MTOR |
0.795 | -0.084 | 1 | 0.606 |
GCN2 |
0.794 | -0.139 | 2 | 0.702 |
BMPR1A |
0.794 | 0.243 | 1 | 0.844 |
ACVR2B |
0.793 | 0.188 | -2 | 0.726 |
CAMLCK |
0.793 | 0.037 | -2 | 0.734 |
DAPK2 |
0.792 | 0.070 | -3 | 0.815 |
GRK6 |
0.792 | 0.062 | 1 | 0.775 |
TGFBR1 |
0.792 | 0.138 | -2 | 0.749 |
NDR1 |
0.792 | 0.002 | -3 | 0.781 |
CDKL5 |
0.792 | 0.035 | -3 | 0.753 |
PKN3 |
0.792 | -0.005 | -3 | 0.780 |
P90RSK |
0.792 | 0.032 | -3 | 0.736 |
PIM1 |
0.791 | 0.079 | -3 | 0.737 |
NIK |
0.791 | 0.020 | -3 | 0.824 |
MLK1 |
0.791 | -0.026 | 2 | 0.738 |
TBK1 |
0.791 | -0.134 | 1 | 0.578 |
FAM20C |
0.791 | 0.103 | 2 | 0.618 |
CHAK2 |
0.791 | -0.003 | -1 | 0.787 |
PDHK4 |
0.790 | -0.256 | 1 | 0.692 |
ACVR2A |
0.790 | 0.144 | -2 | 0.711 |
HIPK4 |
0.790 | 0.030 | 1 | 0.614 |
CAMK2G |
0.789 | -0.087 | 2 | 0.727 |
IKKE |
0.789 | -0.133 | 1 | 0.575 |
SRPK2 |
0.788 | 0.089 | -3 | 0.639 |
ALK4 |
0.788 | 0.095 | -2 | 0.759 |
ATR |
0.788 | -0.088 | 1 | 0.668 |
MAPKAPK2 |
0.788 | 0.048 | -3 | 0.680 |
ALK2 |
0.788 | 0.160 | -2 | 0.758 |
SRPK3 |
0.788 | 0.102 | -3 | 0.691 |
IRE1 |
0.788 | 0.030 | 1 | 0.652 |
RSK3 |
0.788 | 0.019 | -3 | 0.727 |
TSSK2 |
0.787 | 0.055 | -5 | 0.823 |
ULK2 |
0.787 | -0.164 | 2 | 0.694 |
RIPK1 |
0.787 | -0.028 | 1 | 0.659 |
GRK7 |
0.787 | 0.123 | 1 | 0.692 |
MAPKAPK3 |
0.787 | 0.011 | -3 | 0.717 |
GRK4 |
0.786 | -0.003 | -2 | 0.775 |
HUNK |
0.786 | -0.043 | 2 | 0.751 |
P70S6KB |
0.786 | 0.019 | -3 | 0.742 |
CLK1 |
0.786 | 0.092 | -3 | 0.701 |
CLK4 |
0.786 | 0.067 | -3 | 0.724 |
NEK6 |
0.785 | -0.066 | -2 | 0.758 |
PKCD |
0.785 | 0.023 | 2 | 0.697 |
TSSK1 |
0.785 | 0.055 | -3 | 0.828 |
PKACG |
0.785 | 0.002 | -2 | 0.651 |
MLK3 |
0.785 | 0.031 | 2 | 0.659 |
MARK4 |
0.785 | -0.049 | 4 | 0.767 |
MYLK4 |
0.784 | 0.050 | -2 | 0.686 |
IKKA |
0.784 | -0.045 | -2 | 0.655 |
AURB |
0.784 | 0.043 | -2 | 0.564 |
RSK4 |
0.784 | 0.068 | -3 | 0.709 |
PDHK1 |
0.784 | -0.241 | 1 | 0.670 |
AMPKA1 |
0.784 | -0.014 | -3 | 0.802 |
DRAK1 |
0.784 | 0.143 | 1 | 0.744 |
ANKRD3 |
0.782 | -0.050 | 1 | 0.701 |
DYRK2 |
0.782 | 0.013 | 1 | 0.538 |
GRK2 |
0.782 | 0.091 | -2 | 0.665 |
CAMK2D |
0.782 | -0.047 | -3 | 0.779 |
PKR |
0.781 | 0.073 | 1 | 0.698 |
LATS1 |
0.781 | 0.057 | -3 | 0.807 |
PKACB |
0.781 | 0.052 | -2 | 0.590 |
NEK7 |
0.781 | -0.176 | -3 | 0.755 |
PRKD3 |
0.781 | 0.039 | -3 | 0.703 |
LATS2 |
0.781 | -0.046 | -5 | 0.686 |
DLK |
0.780 | -0.067 | 1 | 0.704 |
CK1E |
0.780 | 0.093 | -3 | 0.568 |
PKCG |
0.780 | 0.037 | 2 | 0.657 |
ICK |
0.780 | -0.025 | -3 | 0.795 |
PKCB |
0.780 | 0.034 | 2 | 0.652 |
PKCA |
0.780 | 0.043 | 2 | 0.646 |
CDK18 |
0.780 | 0.016 | 1 | 0.458 |
MNK2 |
0.779 | 0.020 | -2 | 0.679 |
CAMK2B |
0.779 | 0.020 | 2 | 0.709 |
MASTL |
0.779 | -0.199 | -2 | 0.713 |
PAK1 |
0.779 | -0.018 | -2 | 0.662 |
CAMK2A |
0.778 | 0.033 | 2 | 0.722 |
MSK1 |
0.778 | 0.028 | -3 | 0.700 |
WNK3 |
0.778 | -0.200 | 1 | 0.641 |
CAMK4 |
0.777 | -0.072 | -3 | 0.761 |
CDK1 |
0.777 | 0.003 | 1 | 0.501 |
ATM |
0.777 | -0.055 | 1 | 0.621 |
AKT2 |
0.777 | 0.054 | -3 | 0.650 |
PRKX |
0.777 | 0.070 | -3 | 0.649 |
PKG2 |
0.777 | 0.026 | -2 | 0.588 |
MLK4 |
0.777 | -0.008 | 2 | 0.638 |
MLK2 |
0.776 | -0.107 | 2 | 0.721 |
TTBK2 |
0.776 | -0.119 | 2 | 0.611 |
HIPK1 |
0.776 | 0.049 | 1 | 0.553 |
AURA |
0.776 | 0.012 | -2 | 0.539 |
MELK |
0.776 | -0.020 | -3 | 0.748 |
AMPKA2 |
0.776 | -0.032 | -3 | 0.769 |
NIM1 |
0.775 | -0.096 | 3 | 0.737 |
ULK1 |
0.775 | -0.196 | -3 | 0.735 |
HIPK2 |
0.775 | 0.035 | 1 | 0.458 |
PLK1 |
0.775 | -0.041 | -2 | 0.682 |
PIM2 |
0.775 | 0.069 | -3 | 0.699 |
IRE2 |
0.775 | -0.031 | 2 | 0.672 |
MSK2 |
0.775 | -0.031 | -3 | 0.697 |
MNK1 |
0.774 | 0.020 | -2 | 0.683 |
JNK2 |
0.774 | 0.011 | 1 | 0.460 |
PAK3 |
0.774 | -0.060 | -2 | 0.657 |
CDK7 |
0.774 | -0.052 | 1 | 0.517 |
BCKDK |
0.774 | -0.210 | -1 | 0.729 |
NEK9 |
0.774 | -0.169 | 2 | 0.744 |
MST3 |
0.774 | 0.113 | 2 | 0.779 |
CDK5 |
0.774 | 0.004 | 1 | 0.540 |
MPSK1 |
0.774 | 0.152 | 1 | 0.689 |
YSK4 |
0.774 | -0.072 | 1 | 0.637 |
PASK |
0.773 | 0.131 | -3 | 0.819 |
PHKG1 |
0.772 | -0.058 | -3 | 0.772 |
CDK8 |
0.772 | -0.073 | 1 | 0.495 |
JNK3 |
0.772 | -0.008 | 1 | 0.484 |
SGK3 |
0.772 | 0.025 | -3 | 0.715 |
QSK |
0.772 | -0.038 | 4 | 0.754 |
PAK6 |
0.772 | -0.006 | -2 | 0.582 |
MARK3 |
0.772 | -0.012 | 4 | 0.706 |
VRK2 |
0.772 | -0.101 | 1 | 0.701 |
CK1D |
0.771 | 0.087 | -3 | 0.520 |
QIK |
0.771 | -0.090 | -3 | 0.776 |
MEK1 |
0.771 | -0.110 | 2 | 0.765 |
PKCH |
0.771 | -0.017 | 2 | 0.638 |
CDK13 |
0.771 | -0.027 | 1 | 0.483 |
CDK10 |
0.771 | 0.053 | 1 | 0.487 |
P38A |
0.771 | -0.019 | 1 | 0.545 |
DYRK4 |
0.770 | 0.031 | 1 | 0.474 |
PKCZ |
0.770 | -0.028 | 2 | 0.689 |
CDK19 |
0.770 | -0.059 | 1 | 0.464 |
CAMK1G |
0.770 | -0.006 | -3 | 0.703 |
NUAK1 |
0.770 | -0.056 | -3 | 0.727 |
PRP4 |
0.770 | 0.067 | -3 | 0.779 |
GRK3 |
0.770 | 0.071 | -2 | 0.646 |
CDK17 |
0.769 | -0.023 | 1 | 0.415 |
DCAMKL1 |
0.769 | 0.013 | -3 | 0.742 |
GAK |
0.769 | 0.210 | 1 | 0.771 |
MEKK3 |
0.769 | -0.019 | 1 | 0.668 |
CDK14 |
0.769 | 0.008 | 1 | 0.497 |
CHAK1 |
0.768 | -0.098 | 2 | 0.673 |
ERK1 |
0.768 | -0.030 | 1 | 0.467 |
PERK |
0.768 | -0.072 | -2 | 0.763 |
BRSK1 |
0.768 | -0.047 | -3 | 0.739 |
CK2A2 |
0.767 | 0.102 | 1 | 0.770 |
CK1A2 |
0.767 | 0.062 | -3 | 0.518 |
PAK2 |
0.767 | -0.082 | -2 | 0.644 |
P38B |
0.766 | -0.026 | 1 | 0.482 |
SMG1 |
0.766 | -0.094 | 1 | 0.609 |
P38G |
0.766 | -0.023 | 1 | 0.406 |
TLK2 |
0.766 | -0.107 | 1 | 0.640 |
CDK16 |
0.766 | 0.012 | 1 | 0.427 |
IRAK4 |
0.765 | -0.024 | 1 | 0.639 |
CDK12 |
0.765 | -0.023 | 1 | 0.452 |
SMMLCK |
0.765 | 0.006 | -3 | 0.763 |
HIPK3 |
0.765 | 0.004 | 1 | 0.520 |
SIK |
0.765 | -0.064 | -3 | 0.710 |
WNK4 |
0.765 | -0.034 | -2 | 0.767 |
DAPK3 |
0.764 | 0.062 | -3 | 0.754 |
NEK2 |
0.764 | -0.119 | 2 | 0.719 |
SSTK |
0.764 | 0.010 | 4 | 0.749 |
PKACA |
0.763 | 0.015 | -2 | 0.551 |
MARK2 |
0.763 | -0.069 | 4 | 0.672 |
AKT1 |
0.763 | 0.026 | -3 | 0.663 |
BRSK2 |
0.763 | -0.100 | -3 | 0.752 |
CDK2 |
0.763 | -0.069 | 1 | 0.574 |
MEK5 |
0.763 | -0.133 | 2 | 0.740 |
CDK3 |
0.763 | -0.019 | 1 | 0.438 |
BRAF |
0.763 | -0.058 | -4 | 0.789 |
CDK9 |
0.763 | -0.055 | 1 | 0.487 |
MEKK2 |
0.762 | -0.044 | 2 | 0.707 |
HRI |
0.762 | -0.126 | -2 | 0.747 |
SNRK |
0.762 | -0.159 | 2 | 0.605 |
PLK4 |
0.762 | -0.122 | 2 | 0.562 |
DAPK1 |
0.761 | 0.068 | -3 | 0.741 |
DNAPK |
0.761 | -0.072 | 1 | 0.510 |
BUB1 |
0.761 | 0.161 | -5 | 0.775 |
DYRK1A |
0.761 | -0.028 | 1 | 0.545 |
ZAK |
0.761 | -0.094 | 1 | 0.625 |
PLK3 |
0.761 | -0.118 | 2 | 0.711 |
CK2A1 |
0.761 | 0.106 | 1 | 0.754 |
GSK3B |
0.761 | 0.027 | 4 | 0.442 |
DCAMKL2 |
0.760 | -0.032 | -3 | 0.755 |
MAPKAPK5 |
0.760 | -0.099 | -3 | 0.644 |
TLK1 |
0.760 | -0.092 | -2 | 0.771 |
DYRK3 |
0.760 | -0.003 | 1 | 0.551 |
TAO3 |
0.760 | -0.006 | 1 | 0.647 |
GCK |
0.760 | 0.098 | 1 | 0.688 |
GSK3A |
0.760 | 0.045 | 4 | 0.450 |
CHK1 |
0.760 | -0.074 | -3 | 0.760 |
MARK1 |
0.759 | -0.081 | 4 | 0.726 |
ERK2 |
0.759 | -0.070 | 1 | 0.490 |
DYRK1B |
0.759 | -0.016 | 1 | 0.501 |
MEKK1 |
0.759 | -0.132 | 1 | 0.639 |
NEK5 |
0.759 | -0.077 | 1 | 0.670 |
PKCT |
0.759 | -0.028 | 2 | 0.640 |
PKCE |
0.758 | 0.042 | 2 | 0.648 |
HPK1 |
0.758 | 0.092 | 1 | 0.668 |
CK1G1 |
0.757 | -0.022 | -3 | 0.558 |
PKCI |
0.757 | -0.011 | 2 | 0.670 |
P70S6K |
0.757 | -0.023 | -3 | 0.648 |
P38D |
0.756 | -0.026 | 1 | 0.406 |
PHKG2 |
0.756 | -0.060 | -3 | 0.749 |
NEK11 |
0.754 | -0.085 | 1 | 0.640 |
PINK1 |
0.754 | -0.158 | 1 | 0.676 |
MAK |
0.753 | 0.047 | -2 | 0.610 |
AKT3 |
0.753 | 0.033 | -3 | 0.592 |
CHK2 |
0.753 | 0.025 | -3 | 0.593 |
MINK |
0.752 | 0.031 | 1 | 0.650 |
TNIK |
0.752 | 0.066 | 3 | 0.831 |
IRAK1 |
0.752 | -0.161 | -1 | 0.724 |
TAO2 |
0.752 | -0.044 | 2 | 0.756 |
EEF2K |
0.752 | 0.036 | 3 | 0.804 |
JNK1 |
0.752 | -0.026 | 1 | 0.458 |
CAMK1D |
0.751 | -0.019 | -3 | 0.626 |
MST2 |
0.751 | -0.035 | 1 | 0.683 |
TAK1 |
0.751 | 0.011 | 1 | 0.688 |
LKB1 |
0.751 | -0.037 | -3 | 0.763 |
CAMKK1 |
0.750 | -0.119 | -2 | 0.658 |
KHS2 |
0.750 | 0.104 | 1 | 0.654 |
TTBK1 |
0.750 | -0.165 | 2 | 0.539 |
MEKK6 |
0.750 | -0.038 | 1 | 0.634 |
NEK8 |
0.749 | -0.135 | 2 | 0.734 |
HGK |
0.749 | 0.006 | 3 | 0.845 |
CAMKK2 |
0.749 | -0.104 | -2 | 0.656 |
ERK7 |
0.749 | -0.013 | 2 | 0.487 |
PDK1 |
0.749 | -0.084 | 1 | 0.617 |
MRCKB |
0.749 | 0.020 | -3 | 0.688 |
PAK5 |
0.748 | -0.065 | -2 | 0.519 |
CDK6 |
0.748 | -0.007 | 1 | 0.467 |
KHS1 |
0.747 | 0.057 | 1 | 0.631 |
SGK1 |
0.747 | 0.022 | -3 | 0.571 |
LRRK2 |
0.746 | -0.056 | 2 | 0.762 |
ROCK2 |
0.746 | 0.027 | -3 | 0.738 |
PAK4 |
0.746 | -0.056 | -2 | 0.527 |
PBK |
0.746 | 0.091 | 1 | 0.701 |
PKN1 |
0.746 | -0.034 | -3 | 0.666 |
NEK4 |
0.746 | -0.115 | 1 | 0.631 |
MAP3K15 |
0.745 | -0.066 | 1 | 0.595 |
VRK1 |
0.745 | -0.078 | 2 | 0.777 |
HASPIN |
0.745 | 0.139 | -1 | 0.737 |
MOK |
0.744 | 0.013 | 1 | 0.586 |
LOK |
0.744 | -0.045 | -2 | 0.660 |
MRCKA |
0.743 | -0.008 | -3 | 0.692 |
DMPK1 |
0.743 | 0.061 | -3 | 0.713 |
MST1 |
0.742 | -0.054 | 1 | 0.652 |
CAMK1A |
0.742 | -0.013 | -3 | 0.612 |
CDK4 |
0.742 | -0.030 | 1 | 0.441 |
PLK2 |
0.740 | -0.053 | -3 | 0.733 |
SLK |
0.739 | -0.071 | -2 | 0.620 |
NEK1 |
0.739 | -0.104 | 1 | 0.638 |
TTK |
0.739 | 0.008 | -2 | 0.731 |
STK33 |
0.738 | -0.120 | 2 | 0.543 |
BIKE |
0.737 | 0.128 | 1 | 0.688 |
YSK1 |
0.736 | -0.059 | 2 | 0.722 |
RIPK2 |
0.736 | -0.218 | 1 | 0.585 |
CK1A |
0.736 | 0.045 | -3 | 0.438 |
TXK |
0.735 | 0.273 | 1 | 0.814 |
PDHK3_TYR |
0.735 | 0.156 | 4 | 0.826 |
EPHA6 |
0.735 | 0.211 | -1 | 0.827 |
SBK |
0.734 | -0.006 | -3 | 0.529 |
ROCK1 |
0.732 | 0.003 | -3 | 0.697 |
OSR1 |
0.732 | -0.026 | 2 | 0.716 |
BMPR2_TYR |
0.731 | 0.167 | -1 | 0.826 |
CRIK |
0.731 | 0.027 | -3 | 0.662 |
EPHB4 |
0.730 | 0.157 | -1 | 0.783 |
TESK1_TYR |
0.729 | 0.043 | 3 | 0.836 |
MEK2 |
0.728 | -0.257 | 2 | 0.722 |
MYO3B |
0.728 | -0.004 | 2 | 0.737 |
PDHK4_TYR |
0.728 | 0.090 | 2 | 0.813 |
YANK3 |
0.728 | -0.062 | 2 | 0.366 |
ALPHAK3 |
0.728 | -0.005 | -1 | 0.701 |
BLK |
0.728 | 0.218 | -1 | 0.800 |
PKG1 |
0.728 | -0.057 | -2 | 0.509 |
LCK |
0.728 | 0.205 | -1 | 0.802 |
MAP2K6_TYR |
0.727 | 0.090 | -1 | 0.791 |
FYN |
0.725 | 0.210 | -1 | 0.794 |
ITK |
0.725 | 0.163 | -1 | 0.759 |
PKMYT1_TYR |
0.725 | 0.006 | 3 | 0.818 |
MAP2K4_TYR |
0.725 | -0.001 | -1 | 0.789 |
PDHK1_TYR |
0.725 | 0.051 | -1 | 0.814 |
HCK |
0.724 | 0.141 | -1 | 0.794 |
AAK1 |
0.724 | 0.154 | 1 | 0.608 |
YES1 |
0.724 | 0.099 | -1 | 0.784 |
MYO3A |
0.723 | -0.047 | 1 | 0.626 |
SRMS |
0.723 | 0.150 | 1 | 0.790 |
NEK3 |
0.722 | -0.168 | 1 | 0.565 |
FGR |
0.722 | 0.079 | 1 | 0.758 |
EPHA4 |
0.722 | 0.112 | 2 | 0.732 |
ASK1 |
0.721 | -0.112 | 1 | 0.585 |
ABL2 |
0.720 | 0.058 | -1 | 0.738 |
BMX |
0.719 | 0.110 | -1 | 0.678 |
MAP2K7_TYR |
0.719 | -0.194 | 2 | 0.777 |
PINK1_TYR |
0.719 | -0.116 | 1 | 0.692 |
TAO1 |
0.719 | -0.089 | 1 | 0.552 |
LIMK2_TYR |
0.719 | -0.015 | -3 | 0.830 |
EPHB2 |
0.719 | 0.121 | -1 | 0.768 |
EPHB1 |
0.718 | 0.090 | 1 | 0.765 |
TNK2 |
0.717 | 0.057 | 3 | 0.752 |
TYRO3 |
0.717 | -0.019 | 3 | 0.783 |
FER |
0.717 | 0.014 | 1 | 0.781 |
ABL1 |
0.717 | 0.041 | -1 | 0.734 |
EPHB3 |
0.716 | 0.075 | -1 | 0.768 |
PTK2 |
0.715 | 0.198 | -1 | 0.811 |
TEC |
0.715 | 0.083 | -1 | 0.696 |
MERTK |
0.714 | 0.066 | 3 | 0.780 |
EPHA7 |
0.713 | 0.081 | 2 | 0.720 |
RET |
0.713 | -0.129 | 1 | 0.618 |
CSF1R |
0.712 | -0.045 | 3 | 0.789 |
PTK2B |
0.712 | 0.118 | -1 | 0.724 |
MST1R |
0.712 | -0.108 | 3 | 0.793 |
ROS1 |
0.711 | -0.087 | 3 | 0.758 |
LYN |
0.711 | 0.083 | 3 | 0.733 |
SRC |
0.711 | 0.106 | -1 | 0.775 |
INSRR |
0.710 | -0.021 | 3 | 0.738 |
LIMK1_TYR |
0.709 | -0.184 | 2 | 0.758 |
FRK |
0.708 | 0.041 | -1 | 0.788 |
SYK |
0.708 | 0.182 | -1 | 0.756 |
JAK3 |
0.708 | -0.071 | 1 | 0.606 |
KDR |
0.708 | -0.035 | 3 | 0.769 |
DDR1 |
0.707 | -0.152 | 4 | 0.750 |
KIT |
0.707 | -0.053 | 3 | 0.794 |
BTK |
0.706 | -0.037 | -1 | 0.722 |
EPHA3 |
0.706 | -0.002 | 2 | 0.691 |
TYK2 |
0.706 | -0.222 | 1 | 0.616 |
JAK2 |
0.706 | -0.177 | 1 | 0.599 |
EPHA1 |
0.706 | 0.008 | 3 | 0.779 |
MET |
0.706 | -0.011 | 3 | 0.779 |
EPHA5 |
0.706 | 0.074 | 2 | 0.712 |
AXL |
0.705 | -0.051 | 3 | 0.771 |
WEE1_TYR |
0.705 | -0.017 | -1 | 0.690 |
STLK3 |
0.704 | -0.204 | 1 | 0.594 |
FGFR2 |
0.703 | -0.108 | 3 | 0.784 |
TNK1 |
0.703 | -0.054 | 3 | 0.772 |
TEK |
0.703 | -0.087 | 3 | 0.736 |
EPHA8 |
0.702 | 0.038 | -1 | 0.771 |
PDGFRB |
0.701 | -0.148 | 3 | 0.794 |
FLT3 |
0.701 | -0.120 | 3 | 0.800 |
CK1G3 |
0.701 | -0.028 | -3 | 0.398 |
FLT1 |
0.700 | -0.036 | -1 | 0.791 |
CK1G2 |
0.698 | 0.022 | -3 | 0.483 |
ERBB2 |
0.698 | -0.088 | 1 | 0.619 |
ALK |
0.698 | -0.106 | 3 | 0.708 |
LTK |
0.697 | -0.106 | 3 | 0.731 |
TNNI3K_TYR |
0.697 | -0.080 | 1 | 0.629 |
NTRK1 |
0.695 | -0.148 | -1 | 0.739 |
YANK2 |
0.695 | -0.086 | 2 | 0.374 |
FGFR3 |
0.694 | -0.105 | 3 | 0.758 |
JAK1 |
0.694 | -0.135 | 1 | 0.555 |
PTK6 |
0.694 | -0.168 | -1 | 0.672 |
EPHA2 |
0.693 | 0.033 | -1 | 0.752 |
MATK |
0.693 | -0.078 | -1 | 0.654 |
FGFR1 |
0.693 | -0.187 | 3 | 0.754 |
ERBB4 |
0.693 | 0.031 | 1 | 0.609 |
NEK10_TYR |
0.691 | -0.183 | 1 | 0.498 |
DDR2 |
0.691 | -0.073 | 3 | 0.721 |
PDGFRA |
0.690 | -0.239 | 3 | 0.791 |
FLT4 |
0.690 | -0.152 | 3 | 0.763 |
EGFR |
0.689 | -0.069 | 1 | 0.537 |
NTRK3 |
0.689 | -0.119 | -1 | 0.683 |
INSR |
0.688 | -0.142 | 3 | 0.715 |
NTRK2 |
0.688 | -0.185 | 3 | 0.755 |
CSK |
0.685 | -0.130 | 2 | 0.712 |
FGFR4 |
0.684 | -0.099 | -1 | 0.701 |
ZAP70 |
0.683 | 0.047 | -1 | 0.669 |
FES |
0.681 | -0.026 | -1 | 0.658 |
IGF1R |
0.679 | -0.111 | 3 | 0.661 |
MUSK |
0.678 | -0.130 | 1 | 0.536 |