Motif 511 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1A5D9 | BICDL2 | S21 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| O00571 | DDX3X | S34 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14513 | NCKAP5 | S1282 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14545 | TRAFD1 | S409 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14654 | IRS4 | S1061 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15047 | SETD1A | S534 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O43303 | CCP110 | S366 | ochoa|psp | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}. |
| O43432 | EIF4G3 | S1110 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43609 | SPRY1 | S50 | ochoa | Protein sprouty homolog 1 (Spry-1) | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9QXV9}. |
| O43663 | PRC1 | S472 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O60239 | SH3BP5 | S356 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
| O60716 | CTNND1 | S252 | ochoa|psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60716 | CTNND1 | S352 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75044 | SRGAP2 | S427 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75376 | NCOR1 | S2380 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75385 | ULK1 | S758 | ochoa|psp | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75410 | TACC1 | S228 | psp | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75533 | SF3B1 | S322 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75581 | LRP6 | Y1562 | ochoa | Low-density lipoprotein receptor-related protein 6 (LRP-6) | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}. |
| O95425 | SVIL | S620 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| P07910 | HNRNPC | Y139 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P0C7U0 | ELFN1 | S759 | ochoa | Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) | Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}. |
| P0DJJ0 | SRGAP2C | S427 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1) | Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}. |
| P0DMP2 | SRGAP2B | S426 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2) | May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). {ECO:0000269|PubMed:31822692, ECO:0000305|PubMed:22559944, ECO:0000305|PubMed:31822692}. |
| P11274 | BCR | S222 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P12956 | XRCC6 | S306 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P17252 | PRKCA | S226 | ochoa|psp | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P29375 | KDM5A | S198 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P30260 | CDC27 | S364 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P38159 | RBMX | S91 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P46013 | MKI67 | S634 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46087 | NOP2 | S786 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46937 | YAP1 | S94 | psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P50747 | HLCS | S141 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P51116 | FXR2 | S533 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P56373 | P2RX3 | S269 | psp | P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) | Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity). {ECO:0000250|UniProtKB:Q3UR32, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:27626375, ECO:0000269|PubMed:29674445, ECO:0000269|PubMed:31232692}. |
| P60709 | ACTB | S300 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61160 | ACTR2 | S307 | ochoa | Actin-related protein 2 (Actin-like protein 2) | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}. |
| P63261 | ACTG1 | S300 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| Q02952 | AKAP12 | S612 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | S2361 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05397 | PTK2 | S705 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q06710 | PAX8 | S212 | ochoa | Paired box protein Pax-8 | Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. |
| Q07157 | TJP1 | S300 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07352 | ZFP36L1 | S70 | ochoa | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}. |
| Q08999 | RBL2 | Y667 | ochoa | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q12767 | TMEM94 | S454 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12774 | ARHGEF5 | S892 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13370 | PDE3B | S280 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13415 | ORC1 | S182 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q14493 | SLBP | S59 | ochoa | Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) | RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}. |
| Q14966 | ZNF638 | S1490 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14999 | CUL7 | S1129 | ochoa | Cullin-7 (CUL-7) | Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. {ECO:0000269|PubMed:12481031, ECO:0000269|PubMed:12904573, ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:21737058, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:35982156}. |
| Q14CZ8 | HEPACAM | S318 | ochoa | Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) | Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205). {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256, ECO:0000269|PubMed:22405205}. |
| Q15021 | NCAPD2 | S1333 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15527 | SURF2 | S166 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q16513 | PKN2 | S952 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16666 | IFI16 | S145 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q16825 | PTPN21 | S616 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q32MQ0 | ZNF750 | S360 | ochoa | Zinc finger protein 750 | Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. {ECO:0000269|PubMed:22364861}. |
| Q4VC05 | BCL7A | S186 | ochoa | B-cell CLL/lymphoma 7 protein family member A | None |
| Q5GLZ8 | HERC4 | S379 | ochoa | Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) | Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000250|UniProtKB:Q6PAV2}. |
| Q5T5Y3 | CAMSAP1 | S431 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5VUB5 | FAM171A1 | S544 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VWQ0 | RSBN1 | S104 | ochoa | Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) | Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}. |
| Q63ZY3 | KANK2 | S158 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q6P4Q7 | CNNM4 | S649 | ochoa | Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}. |
| Q6PJG2 | MIDEAS | S709 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6PKG0 | LARP1 | S143 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6R327 | RICTOR | S1370 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q7KZI7 | MARK2 | S551 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L3V2 | RTL10 | S290 | ochoa | Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) | Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}. |
| Q7L576 | CYFIP1 | S1228 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7L590 | MCM10 | S95 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z417 | NUFIP2 | S333 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z4S6 | KIF21A | S1231 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6B7 | SRGAP1 | S416 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86SQ0 | PHLDB2 | S58 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86VM9 | ZC3H18 | S836 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86X10 | RALGAPB | S373 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q86YS7 | C2CD5 | S637 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q8IWE2 | FAM114A1 | S36 | ochoa | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | May play a role in neuronal cell development. {ECO:0000250}. |
| Q8IX15 | HOMEZ | S429 | ochoa | Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor) | May function as a transcriptional regulator. |
| Q8IY92 | SLX4 | S1309 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N328 | PGBD3 | S92 | ochoa | PiggyBac transposable element-derived protein 3 | Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:22483866}. |
| Q8N3J3 | HROB | S273 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N4C8 | MINK1 | S682 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NDX5 | PHC3 | S266 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8TC05 | MDM1 | S543 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TC05 | MDM1 | S545 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TEA8 | DTD1 | S181 | psp | D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) | Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}. |
| Q92545 | TMEM131 | S1495 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92625 | ANKS1A | S870 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q96BF3 | TMIGD2 | S220 | ochoa|psp | Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1) | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
| Q96JY6 | PDLIM2 | S189 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96S55 | WRNIP1 | S118 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q99569 | PKP4 | S406 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99569 | PKP4 | S1135 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99733 | NAP1L4 | S53 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q9BR77 | CCDC77 | S36 | ochoa | Coiled-coil domain-containing protein 77 | None |
| Q9BR77 | CCDC77 | S189 | ochoa | Coiled-coil domain-containing protein 77 | None |
| Q9BRD0 | BUD13 | S370 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRR8 | GPATCH1 | S357 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BZD6 | PRRG4 | Y155 | ochoa | Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4) | May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (PubMed:28859078). {ECO:0000269|PubMed:28859078}. |
| Q9H0X9 | OSBPL5 | S66 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H3P2 | NELFA | S233 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H425 | C1orf198 | S281 | ochoa | Uncharacterized protein C1orf198 | None |
| Q9H4B6 | SAV1 | S269 | psp | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}. |
| Q9H4E7 | DEF6 | S565 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H4E7 | DEF6 | S566 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H7M9 | VSIR | S264 | ochoa | V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) | Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}. |
| Q9H992 | MARCHF7 | S388 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9HCD6 | TANC2 | S428 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NYB0 | TERF2IP | S28 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NYF8 | BCLAF1 | S300 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P265 | DIP2B | S75 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P270 | SLAIN2 | S72 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UHJ3 | SFMBT1 | S744 | ochoa | Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1) | Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. {ECO:0000269|PubMed:17599839, ECO:0000269|PubMed:23349461, ECO:0000269|PubMed:23592795}. |
| Q9UHY8 | FEZ2 | S65 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UIS9 | MBD1 | S393 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UKV3 | ACIN1 | S838 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UMS6 | SYNPO2 | S595 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9Y2H0 | DLGAP4 | S611 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y4B6 | DCAF1 | S1006 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y572 | RIPK3 | S410 | ochoa | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y657 | SPIN1 | S38 | ochoa | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| Q99575 | POP1 | S129 | Sugiyama | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| P11310 | ACADM | Y67 | Sugiyama | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH) | Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:1970566, PubMed:21237683, PubMed:2251268, PubMed:8823175). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:2251268). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:15159392, PubMed:25416781). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:1970566, PubMed:21237683, PubMed:2251268, PubMed:8823175). {ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:1970566, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:2251268, ECO:0000269|PubMed:25416781, ECO:0000269|PubMed:8823175}. |
| Q12805 | EFEMP1 | S196 | Sugiyama | EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. {ECO:0000269|PubMed:19804359, ECO:0000269|PubMed:19887559, ECO:0000269|PubMed:20005202}. |
| Q14152 | EIF3A | S907 | Sugiyama | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O75909 | CCNK | S36 | Sugiyama | Cyclin-K | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}. |
| Q92785 | DPF2 | S68 | Sugiyama | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| P56645 | PER3 | S634 | SIGNOR|iPTMNet | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
| Q01844 | EWSR1 | S443 | Sugiyama | RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. {ECO:0000269|PubMed:10767297, ECO:0000269|PubMed:21256132}. |
| Q14671 | PUM1 | S180 | Sugiyama | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| Q96L34 | MARK4 | S496 | Sugiyama | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
| Q14524 | SCN5A | S1998 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.000214 | 3.669 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.000239 | 3.621 |
| R-HSA-194138 | Signaling by VEGF | 0.000390 | 3.409 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.000694 | 3.158 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.000811 | 3.091 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.001080 | 2.967 |
| R-HSA-2028269 | Signaling by Hippo | 0.001233 | 2.909 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.001552 | 2.809 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.001773 | 2.751 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.002661 | 2.575 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.003245 | 2.489 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.003245 | 2.489 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.003347 | 2.475 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.003546 | 2.450 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.003862 | 2.413 |
| R-HSA-196025 | Formation of annular gap junctions | 0.004939 | 2.306 |
| R-HSA-190873 | Gap junction degradation | 0.005842 | 2.233 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.005700 | 2.244 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.006815 | 2.167 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.007422 | 2.129 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.007984 | 2.098 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.008963 | 2.048 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.011373 | 1.944 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.015755 | 1.803 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.016745 | 1.776 |
| R-HSA-9664407 | Parasite infection | 0.016745 | 1.776 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.016745 | 1.776 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.016921 | 1.772 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.014034 | 1.853 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.013974 | 1.855 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.012673 | 1.897 |
| R-HSA-4839726 | Chromatin organization | 0.013991 | 1.854 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.016071 | 1.794 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.014034 | 1.853 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.016761 | 1.776 |
| R-HSA-75153 | Apoptotic execution phase | 0.014681 | 1.833 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.017159 | 1.766 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.018476 | 1.733 |
| R-HSA-72172 | mRNA Splicing | 0.019628 | 1.707 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.021723 | 1.663 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.023350 | 1.632 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.023782 | 1.624 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.023686 | 1.626 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.026687 | 1.574 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.026998 | 1.569 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.072290 | 1.141 |
| R-HSA-165160 | PDE3B signalling | 0.072290 | 1.141 |
| R-HSA-109703 | PKB-mediated events | 0.072290 | 1.141 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.072290 | 1.141 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 0.072290 | 1.141 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.080953 | 1.092 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.080953 | 1.092 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.089536 | 1.048 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.089536 | 1.048 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.098039 | 1.009 |
| R-HSA-164843 | 2-LTR circle formation | 0.114809 | 0.940 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.114809 | 0.940 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.131270 | 0.882 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.038897 | 1.410 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.041043 | 1.387 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.041043 | 1.387 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.155392 | 0.809 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.163284 | 0.787 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.171103 | 0.767 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.171103 | 0.767 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.171103 | 0.767 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.171103 | 0.767 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.186523 | 0.729 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.194126 | 0.712 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.072561 | 1.139 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.201659 | 0.695 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.201659 | 0.695 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.209121 | 0.680 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.216514 | 0.665 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.223839 | 0.650 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.238284 | 0.623 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.109493 | 0.961 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.112509 | 0.949 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.259454 | 0.586 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.266379 | 0.574 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.266379 | 0.574 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.266379 | 0.574 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.163266 | 0.787 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.194126 | 0.712 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.237818 | 0.624 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.163284 | 0.787 |
| R-HSA-1538133 | G0 and Early G1 | 0.300054 | 0.523 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.163284 | 0.787 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.077935 | 1.108 |
| R-HSA-157579 | Telomere Maintenance | 0.268939 | 0.570 |
| R-HSA-180786 | Extension of Telomeres | 0.131034 | 0.883 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.114809 | 0.940 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.123078 | 0.910 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.273240 | 0.563 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.150197 | 0.823 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.045464 | 1.342 |
| R-HSA-191650 | Regulation of gap junction activity | 0.054719 | 1.262 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.139386 | 0.856 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.147426 | 0.831 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.163284 | 0.787 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.112509 | 0.949 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.266379 | 0.574 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.106463 | 0.973 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.034741 | 1.459 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.064740 | 1.189 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.186523 | 0.729 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.194126 | 0.712 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.077935 | 1.108 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.293444 | 0.532 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.216514 | 0.665 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.054719 | 1.262 |
| R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 0.131270 | 0.882 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.213755 | 0.670 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.077935 | 1.108 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.091887 | 1.037 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.091887 | 1.037 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.091887 | 1.037 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.155392 | 0.809 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.105978 | 0.975 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.179872 | 0.745 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.217180 | 0.663 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.054719 | 1.262 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.072290 | 1.141 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.163284 | 0.787 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.178849 | 0.748 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.186523 | 0.729 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.231095 | 0.636 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.245407 | 0.610 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.273240 | 0.563 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.293444 | 0.532 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.176530 | 0.753 |
| R-HSA-167172 | Transcription of the HIV genome | 0.159980 | 0.796 |
| R-HSA-9909396 | Circadian clock | 0.051532 | 1.288 |
| R-HSA-69190 | DNA strand elongation | 0.300054 | 0.523 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.089536 | 1.048 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.091887 | 1.037 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.286772 | 0.542 |
| R-HSA-69239 | Synthesis of DNA | 0.102131 | 0.991 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.155567 | 0.808 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.251637 | 0.599 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.098039 | 1.009 |
| R-HSA-3295583 | TRP channels | 0.259454 | 0.586 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.169876 | 0.770 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.047887 | 1.320 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.114809 | 0.940 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.273240 | 0.563 |
| R-HSA-69306 | DNA Replication | 0.078262 | 1.106 |
| R-HSA-196780 | Biotin transport and metabolism | 0.163284 | 0.787 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.059697 | 1.224 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.069506 | 1.158 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.159980 | 0.796 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.054719 | 1.262 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.089536 | 1.048 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.114809 | 0.940 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.114809 | 0.940 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.131270 | 0.882 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.163284 | 0.787 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.178849 | 0.748 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.194126 | 0.712 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.201659 | 0.695 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.252463 | 0.598 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.273240 | 0.563 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.137357 | 0.862 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.286772 | 0.542 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.259454 | 0.586 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.192972 | 0.715 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.223839 | 0.650 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.245407 | 0.610 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.293444 | 0.532 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.114809 | 0.940 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.178849 | 0.748 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.280038 | 0.553 |
| R-HSA-1640170 | Cell Cycle | 0.148380 | 0.829 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.173197 | 0.761 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.102061 | 0.991 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.265478 | 0.576 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.059697 | 1.224 |
| R-HSA-1462054 | Alpha-defensins | 0.098039 | 1.009 |
| R-HSA-69109 | Leading Strand Synthesis | 0.139386 | 0.856 |
| R-HSA-69091 | Polymerase switching | 0.139386 | 0.856 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 0.155392 | 0.809 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.201659 | 0.695 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.273240 | 0.563 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.213755 | 0.670 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.300046 | 0.523 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.036154 | 1.442 |
| R-HSA-69242 | S Phase | 0.071953 | 1.143 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.072561 | 1.139 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.146965 | 0.833 |
| R-HSA-69206 | G1/S Transition | 0.043636 | 1.360 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.052406 | 1.281 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.201659 | 0.695 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.280038 | 0.553 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.153445 | 0.814 |
| R-HSA-162587 | HIV Life Cycle | 0.226773 | 0.644 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.219429 | 0.659 |
| R-HSA-162592 | Integration of provirus | 0.131270 | 0.882 |
| R-HSA-437239 | Recycling pathway of L1 | 0.094759 | 1.023 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.150197 | 0.823 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.072290 | 1.141 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.139386 | 0.856 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.139386 | 0.856 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.139386 | 0.856 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.171103 | 0.767 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 0.178849 | 0.748 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.186523 | 0.729 |
| R-HSA-190828 | Gap junction trafficking | 0.086222 | 1.064 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.300054 | 0.523 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.300054 | 0.523 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.047737 | 1.321 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.178849 | 0.748 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.194126 | 0.712 |
| R-HSA-182971 | EGFR downregulation | 0.293444 | 0.532 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.029223 | 1.534 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.043780 | 1.359 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.178849 | 0.748 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 0.178849 | 0.748 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.286772 | 0.542 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.031586 | 1.501 |
| R-HSA-8953854 | Metabolism of RNA | 0.059847 | 1.223 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.179872 | 0.745 |
| R-HSA-9659379 | Sensory processing of sound | 0.196721 | 0.706 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.106463 | 0.973 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.159980 | 0.796 |
| R-HSA-5357801 | Programmed Cell Death | 0.162027 | 0.790 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.075232 | 1.124 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.075232 | 1.124 |
| R-HSA-2559583 | Cellular Senescence | 0.040340 | 1.394 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.226773 | 0.644 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.200115 | 0.699 |
| R-HSA-199991 | Membrane Trafficking | 0.178069 | 0.749 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.155392 | 0.809 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.252463 | 0.598 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.121683 | 0.915 |
| R-HSA-70635 | Urea cycle | 0.259454 | 0.586 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.280038 | 0.553 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.156705 | 0.805 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.090941 | 1.041 |
| R-HSA-73894 | DNA Repair | 0.285552 | 0.544 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.216514 | 0.665 |
| R-HSA-3214842 | HDMs demethylate histones | 0.252463 | 0.598 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.090941 | 1.041 |
| R-HSA-73884 | Base Excision Repair | 0.237818 | 0.624 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.216992 | 0.664 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.186523 | 0.729 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.094759 | 1.023 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.266379 | 0.574 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.300054 | 0.523 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.138670 | 0.858 |
| R-HSA-422475 | Axon guidance | 0.086290 | 1.064 |
| R-HSA-9675108 | Nervous system development | 0.058560 | 1.232 |
| R-HSA-9830364 | Formation of the nephric duct | 0.034741 | 1.459 |
| R-HSA-9658195 | Leishmania infection | 0.154089 | 0.812 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.154089 | 0.812 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.098039 | 1.009 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.155392 | 0.809 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.186523 | 0.729 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.037678 | 1.424 |
| R-HSA-74160 | Gene expression (Transcription) | 0.236381 | 0.626 |
| R-HSA-373760 | L1CAM interactions | 0.123967 | 0.907 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.043914 | 1.357 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.238284 | 0.623 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.156714 | 0.805 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.092000 | 1.036 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.121683 | 0.915 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.216514 | 0.665 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.269164 | 0.570 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.269164 | 0.570 |
| R-HSA-1266738 | Developmental Biology | 0.297597 | 0.526 |
| R-HSA-1989781 | PPARA activates gene expression | 0.221871 | 0.654 |
| R-HSA-162582 | Signal Transduction | 0.206261 | 0.686 |
| R-HSA-3000170 | Syndecan interactions | 0.238284 | 0.623 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.300054 | 0.523 |
| R-HSA-5358508 | Mismatch Repair | 0.194126 | 0.712 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.238284 | 0.623 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.086222 | 1.064 |
| R-HSA-9830369 | Kidney development | 0.156705 | 0.805 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.268939 | 0.570 |
| R-HSA-9758941 | Gastrulation | 0.207305 | 0.683 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.209717 | 0.678 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.275860 | 0.559 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.224044 | 0.650 |
| R-HSA-109581 | Apoptosis | 0.239115 | 0.621 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.244724 | 0.611 |
| R-HSA-212436 | Generic Transcription Pathway | 0.305819 | 0.515 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.306602 | 0.513 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.306602 | 0.513 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.306602 | 0.513 |
| R-HSA-354192 | Integrin signaling | 0.306602 | 0.513 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.306602 | 0.513 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.306602 | 0.513 |
| R-HSA-9930044 | Nuclear RNA decay | 0.306602 | 0.513 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.306602 | 0.513 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.306602 | 0.513 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.306602 | 0.513 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.313090 | 0.504 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.313090 | 0.504 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.313090 | 0.504 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.313090 | 0.504 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.319517 | 0.496 |
| R-HSA-5205647 | Mitophagy | 0.319517 | 0.496 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.319517 | 0.496 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.325885 | 0.487 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.327702 | 0.485 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.329359 | 0.482 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.330940 | 0.480 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.332193 | 0.479 |
| R-HSA-111933 | Calmodulin induced events | 0.332193 | 0.479 |
| R-HSA-111997 | CaM pathway | 0.332193 | 0.479 |
| R-HSA-8853659 | RET signaling | 0.332193 | 0.479 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.332193 | 0.479 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.338443 | 0.471 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.338443 | 0.471 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.343222 | 0.464 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.344634 | 0.463 |
| R-HSA-8875878 | MET promotes cell motility | 0.344634 | 0.463 |
| R-HSA-73927 | Depurination | 0.344634 | 0.463 |
| R-HSA-1566948 | Elastic fibre formation | 0.344634 | 0.463 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.350768 | 0.455 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.350768 | 0.455 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.350768 | 0.455 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.350768 | 0.455 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.350768 | 0.455 |
| R-HSA-5693538 | Homology Directed Repair | 0.351334 | 0.454 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.356845 | 0.448 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.356845 | 0.448 |
| R-HSA-167169 | HIV Transcription Elongation | 0.356845 | 0.448 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.356845 | 0.448 |
| R-HSA-73886 | Chromosome Maintenance | 0.361453 | 0.442 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.362866 | 0.440 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.362866 | 0.440 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.362866 | 0.440 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.362866 | 0.440 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.362866 | 0.440 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.368830 | 0.433 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.368830 | 0.433 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.373586 | 0.428 |
| R-HSA-111996 | Ca-dependent events | 0.374739 | 0.426 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.374739 | 0.426 |
| R-HSA-73928 | Depyrimidination | 0.374739 | 0.426 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.375014 | 0.426 |
| R-HSA-1461973 | Defensins | 0.380593 | 0.420 |
| R-HSA-8854214 | TBC/RABGAPs | 0.380593 | 0.420 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.380593 | 0.420 |
| R-HSA-69481 | G2/M Checkpoints | 0.384830 | 0.415 |
| R-HSA-418990 | Adherens junctions interactions | 0.386248 | 0.413 |
| R-HSA-373752 | Netrin-1 signaling | 0.386393 | 0.413 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.386393 | 0.413 |
| R-HSA-69236 | G1 Phase | 0.386393 | 0.413 |
| R-HSA-1500931 | Cell-Cell communication | 0.386842 | 0.412 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.388688 | 0.410 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.392138 | 0.407 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.392138 | 0.407 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.392138 | 0.407 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.392138 | 0.407 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.397830 | 0.400 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.397830 | 0.400 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.397830 | 0.400 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.397830 | 0.400 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.397830 | 0.400 |
| R-HSA-9843745 | Adipogenesis | 0.401303 | 0.397 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.403470 | 0.394 |
| R-HSA-162906 | HIV Infection | 0.408884 | 0.388 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.409056 | 0.388 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.409056 | 0.388 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.412464 | 0.385 |
| R-HSA-9766229 | Degradation of CDH1 | 0.414591 | 0.382 |
| R-HSA-73893 | DNA Damage Bypass | 0.414591 | 0.382 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.414591 | 0.382 |
| R-HSA-1474244 | Extracellular matrix organization | 0.418461 | 0.378 |
| R-HSA-109704 | PI3K Cascade | 0.420075 | 0.377 |
| R-HSA-2514856 | The phototransduction cascade | 0.425507 | 0.371 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.430422 | 0.366 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.430888 | 0.366 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.430888 | 0.366 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.430888 | 0.366 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.430888 | 0.366 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.436220 | 0.360 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.436220 | 0.360 |
| R-HSA-1221632 | Meiotic synapsis | 0.436220 | 0.360 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.436220 | 0.360 |
| R-HSA-72649 | Translation initiation complex formation | 0.441502 | 0.355 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.441502 | 0.355 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.441502 | 0.355 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.443125 | 0.353 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.446735 | 0.350 |
| R-HSA-418597 | G alpha (z) signalling events | 0.446735 | 0.350 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.446735 | 0.350 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.451919 | 0.345 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.451919 | 0.345 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.451919 | 0.345 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.451919 | 0.345 |
| R-HSA-177929 | Signaling by EGFR | 0.451919 | 0.345 |
| R-HSA-75893 | TNF signaling | 0.451919 | 0.345 |
| R-HSA-112399 | IRS-mediated signalling | 0.457055 | 0.340 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.457055 | 0.340 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.457055 | 0.340 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.462143 | 0.335 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.462143 | 0.335 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.462143 | 0.335 |
| R-HSA-421270 | Cell-cell junction organization | 0.467879 | 0.330 |
| R-HSA-983189 | Kinesins | 0.472178 | 0.326 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.472178 | 0.326 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.472178 | 0.326 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.472178 | 0.326 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.472178 | 0.326 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.472178 | 0.326 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.472178 | 0.326 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.472178 | 0.326 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.474186 | 0.324 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.477125 | 0.321 |
| R-HSA-112043 | PLC beta mediated events | 0.477125 | 0.321 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.479855 | 0.319 |
| R-HSA-73887 | Death Receptor Signaling | 0.480273 | 0.319 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.480342 | 0.318 |
| R-HSA-9707616 | Heme signaling | 0.482026 | 0.317 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.482026 | 0.317 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.482026 | 0.317 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.482026 | 0.317 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.482026 | 0.317 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.482026 | 0.317 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.484611 | 0.315 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.486882 | 0.313 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.486882 | 0.313 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.486882 | 0.313 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.491692 | 0.308 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.498276 | 0.303 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.501179 | 0.300 |
| R-HSA-112040 | G-protein mediated events | 0.505856 | 0.296 |
| R-HSA-5218859 | Regulated Necrosis | 0.510489 | 0.292 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.519628 | 0.284 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.524133 | 0.281 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.524133 | 0.281 |
| R-HSA-68886 | M Phase | 0.524236 | 0.280 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.528596 | 0.277 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.528596 | 0.277 |
| R-HSA-446728 | Cell junction organization | 0.530979 | 0.275 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.533018 | 0.273 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.533018 | 0.273 |
| R-HSA-4086398 | Ca2+ pathway | 0.533018 | 0.273 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.535900 | 0.271 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.537399 | 0.270 |
| R-HSA-380287 | Centrosome maturation | 0.541738 | 0.266 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.541738 | 0.266 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.541738 | 0.266 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.544305 | 0.264 |
| R-HSA-5689603 | UCH proteinases | 0.546038 | 0.263 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.546038 | 0.263 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.550297 | 0.259 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.554516 | 0.256 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.554516 | 0.256 |
| R-HSA-4086400 | PCP/CE pathway | 0.554516 | 0.256 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.555481 | 0.255 |
| R-HSA-6806834 | Signaling by MET | 0.562838 | 0.250 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.566940 | 0.246 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.570675 | 0.244 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.571005 | 0.243 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.571005 | 0.243 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.575031 | 0.240 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.579020 | 0.237 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.582972 | 0.234 |
| R-HSA-1500620 | Meiosis | 0.582972 | 0.234 |
| R-HSA-5617833 | Cilium Assembly | 0.584741 | 0.233 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.586887 | 0.231 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.590765 | 0.229 |
| R-HSA-68877 | Mitotic Prometaphase | 0.592506 | 0.227 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.594607 | 0.226 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.598414 | 0.223 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.598414 | 0.223 |
| R-HSA-9663891 | Selective autophagy | 0.598414 | 0.223 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.609621 | 0.215 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.610206 | 0.215 |
| R-HSA-391251 | Protein folding | 0.616919 | 0.210 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.616919 | 0.210 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.620292 | 0.207 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.627614 | 0.202 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.631112 | 0.200 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.634578 | 0.198 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.638011 | 0.195 |
| R-HSA-422356 | Regulation of insulin secretion | 0.641413 | 0.193 |
| R-HSA-3214847 | HATs acetylate histones | 0.644782 | 0.191 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.644782 | 0.191 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.648120 | 0.188 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.651427 | 0.186 |
| R-HSA-6798695 | Neutrophil degranulation | 0.658497 | 0.181 |
| R-HSA-111885 | Opioid Signalling | 0.661164 | 0.180 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.662267 | 0.179 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.664349 | 0.178 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.664349 | 0.178 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.667505 | 0.176 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.670631 | 0.174 |
| R-HSA-418346 | Platelet homeostasis | 0.670631 | 0.174 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.671330 | 0.173 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.676795 | 0.170 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.676795 | 0.170 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.676795 | 0.170 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.676795 | 0.170 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.677327 | 0.169 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.682845 | 0.166 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.682845 | 0.166 |
| R-HSA-6803157 | Antimicrobial peptides | 0.685828 | 0.164 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.705941 | 0.151 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.705941 | 0.151 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.708708 | 0.150 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.708708 | 0.150 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.711449 | 0.148 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.714164 | 0.146 |
| R-HSA-68875 | Mitotic Prophase | 0.716854 | 0.145 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.727365 | 0.138 |
| R-HSA-5688426 | Deubiquitination | 0.731134 | 0.136 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.732474 | 0.135 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.732474 | 0.135 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.732474 | 0.135 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.745554 | 0.128 |
| R-HSA-1474165 | Reproduction | 0.747238 | 0.127 |
| R-HSA-5576891 | Cardiac conduction | 0.749618 | 0.125 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.751977 | 0.124 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.754313 | 0.122 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.763442 | 0.117 |
| R-HSA-163685 | Integration of energy metabolism | 0.763442 | 0.117 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.764304 | 0.117 |
| R-HSA-2262752 | Cellular responses to stress | 0.764589 | 0.117 |
| R-HSA-6807070 | PTEN Regulation | 0.770066 | 0.113 |
| R-HSA-1632852 | Macroautophagy | 0.774380 | 0.111 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.778613 | 0.109 |
| R-HSA-2187338 | Visual phototransduction | 0.788855 | 0.103 |
| R-HSA-1280218 | Adaptive Immune System | 0.789503 | 0.103 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.790846 | 0.102 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.796807 | 0.099 |
| R-HSA-195721 | Signaling by WNT | 0.801114 | 0.096 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.802406 | 0.096 |
| R-HSA-9612973 | Autophagy | 0.806117 | 0.094 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.813332 | 0.090 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.820280 | 0.086 |
| R-HSA-168249 | Innate Immune System | 0.822111 | 0.085 |
| R-HSA-5663205 | Infectious disease | 0.825158 | 0.083 |
| R-HSA-72306 | tRNA processing | 0.831827 | 0.080 |
| R-HSA-418555 | G alpha (s) signalling events | 0.833415 | 0.079 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.836547 | 0.078 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.839620 | 0.076 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.851350 | 0.070 |
| R-HSA-69275 | G2/M Transition | 0.855526 | 0.068 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.858244 | 0.066 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.858244 | 0.066 |
| R-HSA-983712 | Ion channel transport | 0.859585 | 0.066 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.862227 | 0.064 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.862922 | 0.064 |
| R-HSA-9609690 | HCMV Early Events | 0.868620 | 0.061 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.873522 | 0.059 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.876532 | 0.057 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.877078 | 0.057 |
| R-HSA-109582 | Hemostasis | 0.877849 | 0.057 |
| R-HSA-6805567 | Keratinization | 0.881666 | 0.055 |
| R-HSA-397014 | Muscle contraction | 0.888231 | 0.051 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.888231 | 0.051 |
| R-HSA-68882 | Mitotic Anaphase | 0.892405 | 0.049 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.893424 | 0.049 |
| R-HSA-8951664 | Neddylation | 0.897406 | 0.047 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.905832 | 0.043 |
| R-HSA-72312 | rRNA processing | 0.907609 | 0.042 |
| R-HSA-9679506 | SARS-CoV Infections | 0.909346 | 0.041 |
| R-HSA-8939211 | ESR-mediated signaling | 0.911907 | 0.040 |
| R-HSA-157118 | Signaling by NOTCH | 0.914390 | 0.039 |
| R-HSA-9824446 | Viral Infection Pathways | 0.919042 | 0.037 |
| R-HSA-9609646 | HCMV Infection | 0.922175 | 0.035 |
| R-HSA-416476 | G alpha (q) signalling events | 0.931906 | 0.031 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.934458 | 0.029 |
| R-HSA-112316 | Neuronal System | 0.945575 | 0.024 |
| R-HSA-1483257 | Phospholipid metabolism | 0.949363 | 0.023 |
| R-HSA-168256 | Immune System | 0.955577 | 0.020 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.961269 | 0.017 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.973864 | 0.012 |
| R-HSA-913531 | Interferon Signaling | 0.978435 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.979840 | 0.009 |
| R-HSA-1643685 | Disease | 0.980082 | 0.009 |
| R-HSA-388396 | GPCR downstream signalling | 0.981159 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 0.982884 | 0.007 |
| R-HSA-8978868 | Fatty acid metabolism | 0.982884 | 0.007 |
| R-HSA-5668914 | Diseases of metabolism | 0.985885 | 0.006 |
| R-HSA-72766 | Translation | 0.986154 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 0.990029 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.997789 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 0.998928 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999559 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999732 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999939 | 0.000 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.999976 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999989 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.872 | 0.200 | 2 | 0.891 |
CLK3 |
0.870 | 0.308 | 1 | 0.858 |
CDC7 |
0.865 | 0.158 | 1 | 0.854 |
MOS |
0.863 | 0.260 | 1 | 0.868 |
GRK1 |
0.863 | 0.304 | -2 | 0.848 |
PIM3 |
0.861 | 0.156 | -3 | 0.846 |
NDR2 |
0.861 | 0.154 | -3 | 0.858 |
KIS |
0.855 | 0.196 | 1 | 0.740 |
PRPK |
0.854 | -0.010 | -1 | 0.786 |
MTOR |
0.854 | -0.006 | 1 | 0.776 |
NLK |
0.854 | 0.144 | 1 | 0.836 |
ERK5 |
0.851 | 0.144 | 1 | 0.822 |
IKKB |
0.851 | -0.034 | -2 | 0.756 |
CAMK2G |
0.850 | 0.009 | 2 | 0.847 |
DSTYK |
0.849 | 0.003 | 2 | 0.919 |
SRPK1 |
0.849 | 0.160 | -3 | 0.744 |
GRK5 |
0.848 | 0.042 | -3 | 0.914 |
CDKL5 |
0.848 | 0.104 | -3 | 0.793 |
HIPK4 |
0.847 | 0.153 | 1 | 0.768 |
CDKL1 |
0.847 | 0.062 | -3 | 0.806 |
PKN3 |
0.847 | 0.052 | -3 | 0.834 |
PIM1 |
0.846 | 0.118 | -3 | 0.782 |
PRKD1 |
0.846 | 0.090 | -3 | 0.826 |
ATR |
0.846 | 0.006 | 1 | 0.800 |
PDHK4 |
0.846 | -0.222 | 1 | 0.817 |
RAF1 |
0.846 | -0.116 | 1 | 0.800 |
CAMK1B |
0.845 | -0.018 | -3 | 0.859 |
RSK2 |
0.845 | 0.074 | -3 | 0.760 |
SKMLCK |
0.845 | 0.076 | -2 | 0.854 |
NDR1 |
0.844 | 0.028 | -3 | 0.840 |
TBK1 |
0.844 | -0.086 | 1 | 0.702 |
NUAK2 |
0.844 | 0.051 | -3 | 0.840 |
WNK1 |
0.844 | 0.020 | -2 | 0.884 |
CDK1 |
0.843 | 0.209 | 1 | 0.689 |
BMPR2 |
0.843 | -0.122 | -2 | 0.850 |
GRK6 |
0.843 | 0.074 | 1 | 0.812 |
MST4 |
0.843 | 0.049 | 2 | 0.876 |
GCN2 |
0.843 | -0.166 | 2 | 0.817 |
ICK |
0.843 | 0.102 | -3 | 0.845 |
IKKA |
0.842 | 0.031 | -2 | 0.745 |
LATS2 |
0.842 | 0.057 | -5 | 0.774 |
MARK4 |
0.842 | 0.009 | 4 | 0.856 |
ULK2 |
0.842 | -0.125 | 2 | 0.802 |
PDHK1 |
0.841 | -0.164 | 1 | 0.797 |
SRPK2 |
0.841 | 0.137 | -3 | 0.669 |
PKN2 |
0.841 | 0.040 | -3 | 0.845 |
MLK1 |
0.841 | -0.010 | 2 | 0.845 |
NIK |
0.841 | -0.015 | -3 | 0.889 |
IKKE |
0.841 | -0.097 | 1 | 0.690 |
CHAK2 |
0.841 | 0.013 | -1 | 0.766 |
RIPK3 |
0.841 | -0.045 | 3 | 0.752 |
NEK6 |
0.841 | -0.008 | -2 | 0.806 |
GRK7 |
0.841 | 0.196 | 1 | 0.756 |
CAMK2D |
0.840 | 0.028 | -3 | 0.852 |
AMPKA1 |
0.839 | 0.038 | -3 | 0.854 |
JNK3 |
0.839 | 0.191 | 1 | 0.714 |
LATS1 |
0.839 | 0.162 | -3 | 0.878 |
FAM20C |
0.839 | 0.117 | 2 | 0.659 |
BMPR1B |
0.839 | 0.144 | 1 | 0.790 |
P90RSK |
0.838 | 0.036 | -3 | 0.764 |
CAMLCK |
0.838 | -0.008 | -2 | 0.824 |
CDK5 |
0.838 | 0.202 | 1 | 0.742 |
JNK2 |
0.838 | 0.201 | 1 | 0.682 |
DAPK2 |
0.838 | -0.002 | -3 | 0.877 |
CDK8 |
0.838 | 0.114 | 1 | 0.714 |
CAMK2A |
0.838 | 0.105 | 2 | 0.836 |
HUNK |
0.838 | -0.084 | 2 | 0.825 |
GRK4 |
0.837 | 0.004 | -2 | 0.832 |
CDK7 |
0.837 | 0.127 | 1 | 0.727 |
PKCD |
0.836 | 0.059 | 2 | 0.824 |
MASTL |
0.836 | -0.141 | -2 | 0.823 |
DYRK2 |
0.836 | 0.140 | 1 | 0.722 |
NEK7 |
0.836 | -0.141 | -3 | 0.890 |
PRKD2 |
0.836 | 0.033 | -3 | 0.751 |
AURC |
0.836 | 0.068 | -2 | 0.626 |
PKACG |
0.835 | 0.008 | -2 | 0.718 |
CAMK2B |
0.835 | 0.081 | 2 | 0.816 |
MLK3 |
0.835 | 0.071 | 2 | 0.788 |
RSK3 |
0.835 | 0.010 | -3 | 0.754 |
CLK2 |
0.835 | 0.197 | -3 | 0.730 |
CDK19 |
0.835 | 0.122 | 1 | 0.684 |
BCKDK |
0.835 | -0.128 | -1 | 0.729 |
CDK18 |
0.835 | 0.173 | 1 | 0.668 |
TSSK2 |
0.835 | 0.046 | -5 | 0.863 |
SRPK3 |
0.834 | 0.106 | -3 | 0.731 |
TGFBR2 |
0.834 | -0.080 | -2 | 0.732 |
RSK4 |
0.833 | 0.094 | -3 | 0.736 |
CDK3 |
0.833 | 0.208 | 1 | 0.642 |
MLK2 |
0.833 | 0.001 | 2 | 0.844 |
P70S6KB |
0.833 | -0.003 | -3 | 0.791 |
MAPKAPK2 |
0.833 | 0.039 | -3 | 0.725 |
AMPKA2 |
0.833 | 0.032 | -3 | 0.817 |
CDK13 |
0.833 | 0.130 | 1 | 0.705 |
P38B |
0.832 | 0.174 | 1 | 0.698 |
ATM |
0.831 | -0.000 | 1 | 0.750 |
ULK1 |
0.831 | -0.167 | -3 | 0.846 |
TGFBR1 |
0.831 | 0.037 | -2 | 0.763 |
DLK |
0.831 | -0.108 | 1 | 0.779 |
RIPK1 |
0.830 | -0.122 | 1 | 0.749 |
TSSK1 |
0.830 | 0.035 | -3 | 0.866 |
MAPKAPK3 |
0.830 | -0.034 | -3 | 0.775 |
WNK3 |
0.830 | -0.216 | 1 | 0.757 |
HIPK2 |
0.830 | 0.180 | 1 | 0.646 |
ERK1 |
0.830 | 0.152 | 1 | 0.688 |
PKCA |
0.830 | 0.081 | 2 | 0.769 |
P38A |
0.830 | 0.147 | 1 | 0.749 |
ANKRD3 |
0.830 | -0.109 | 1 | 0.806 |
ALK4 |
0.829 | -0.012 | -2 | 0.794 |
P38G |
0.829 | 0.163 | 1 | 0.613 |
NEK9 |
0.829 | -0.117 | 2 | 0.856 |
CK1E |
0.828 | 0.165 | -3 | 0.687 |
NIM1 |
0.828 | -0.092 | 3 | 0.756 |
CLK4 |
0.828 | 0.077 | -3 | 0.757 |
IRE1 |
0.828 | -0.041 | 1 | 0.720 |
HIPK1 |
0.828 | 0.158 | 1 | 0.736 |
PKCG |
0.828 | 0.030 | 2 | 0.782 |
PKCB |
0.828 | 0.044 | 2 | 0.779 |
CDK2 |
0.827 | 0.104 | 1 | 0.752 |
QSK |
0.827 | -0.001 | 4 | 0.834 |
TTBK2 |
0.827 | -0.110 | 2 | 0.742 |
CDK17 |
0.827 | 0.146 | 1 | 0.622 |
MNK1 |
0.826 | 0.036 | -2 | 0.776 |
DNAPK |
0.826 | 0.045 | 1 | 0.688 |
PKR |
0.826 | 0.005 | 1 | 0.781 |
PAK1 |
0.826 | -0.029 | -2 | 0.765 |
MSK2 |
0.826 | -0.034 | -3 | 0.756 |
MNK2 |
0.825 | 0.004 | -2 | 0.764 |
CLK1 |
0.825 | 0.094 | -3 | 0.721 |
VRK2 |
0.825 | -0.052 | 1 | 0.830 |
CDK12 |
0.824 | 0.120 | 1 | 0.679 |
MSK1 |
0.824 | 0.019 | -3 | 0.755 |
CDK10 |
0.824 | 0.183 | 1 | 0.694 |
SMG1 |
0.824 | -0.019 | 1 | 0.748 |
PKACB |
0.824 | 0.042 | -2 | 0.636 |
YSK4 |
0.824 | -0.059 | 1 | 0.719 |
QIK |
0.824 | -0.096 | -3 | 0.854 |
MPSK1 |
0.824 | 0.203 | 1 | 0.747 |
CDK9 |
0.823 | 0.093 | 1 | 0.712 |
PIM2 |
0.823 | 0.064 | -3 | 0.733 |
CAMK4 |
0.823 | -0.107 | -3 | 0.828 |
ALK2 |
0.823 | 0.040 | -2 | 0.777 |
DYRK4 |
0.823 | 0.149 | 1 | 0.671 |
CDK14 |
0.823 | 0.143 | 1 | 0.705 |
IRE2 |
0.823 | -0.025 | 2 | 0.762 |
MLK4 |
0.822 | -0.023 | 2 | 0.759 |
PKCZ |
0.822 | -0.007 | 2 | 0.810 |
MEK1 |
0.822 | -0.142 | 2 | 0.862 |
MELK |
0.822 | -0.045 | -3 | 0.796 |
MARK3 |
0.822 | -0.003 | 4 | 0.788 |
ERK2 |
0.822 | 0.099 | 1 | 0.715 |
SIK |
0.822 | -0.030 | -3 | 0.769 |
PRKD3 |
0.822 | -0.009 | -3 | 0.729 |
PRKX |
0.822 | 0.067 | -3 | 0.669 |
PASK |
0.822 | 0.114 | -3 | 0.884 |
PAK3 |
0.821 | -0.080 | -2 | 0.763 |
CDK16 |
0.821 | 0.164 | 1 | 0.640 |
PKG2 |
0.821 | 0.019 | -2 | 0.643 |
CK1D |
0.821 | 0.167 | -3 | 0.647 |
AURB |
0.821 | 0.001 | -2 | 0.621 |
SGK3 |
0.820 | 0.027 | -3 | 0.761 |
BRSK1 |
0.820 | -0.032 | -3 | 0.790 |
ACVR2B |
0.820 | -0.016 | -2 | 0.741 |
AKT2 |
0.820 | 0.034 | -3 | 0.674 |
PKCH |
0.820 | -0.014 | 2 | 0.758 |
DRAK1 |
0.820 | -0.056 | 1 | 0.739 |
PHKG1 |
0.819 | -0.045 | -3 | 0.834 |
MYLK4 |
0.819 | -0.032 | -2 | 0.749 |
CHAK1 |
0.819 | -0.103 | 2 | 0.800 |
P38D |
0.819 | 0.162 | 1 | 0.639 |
NUAK1 |
0.819 | -0.061 | -3 | 0.780 |
ACVR2A |
0.819 | -0.042 | -2 | 0.722 |
DYRK1A |
0.819 | 0.088 | 1 | 0.764 |
MARK2 |
0.818 | -0.039 | 4 | 0.763 |
NEK2 |
0.818 | -0.100 | 2 | 0.837 |
DYRK1B |
0.818 | 0.113 | 1 | 0.697 |
PLK1 |
0.817 | -0.148 | -2 | 0.730 |
MST3 |
0.817 | 0.056 | 2 | 0.870 |
BRSK2 |
0.817 | -0.063 | -3 | 0.815 |
PRP4 |
0.817 | 0.045 | -3 | 0.752 |
BMPR1A |
0.817 | 0.070 | 1 | 0.780 |
GRK2 |
0.817 | -0.036 | -2 | 0.713 |
HIPK3 |
0.817 | 0.098 | 1 | 0.732 |
GSK3A |
0.816 | 0.108 | 4 | 0.521 |
CK2A2 |
0.816 | 0.136 | 1 | 0.722 |
PAK6 |
0.816 | 0.006 | -2 | 0.684 |
AURA |
0.815 | -0.015 | -2 | 0.589 |
JNK1 |
0.815 | 0.143 | 1 | 0.675 |
PAK2 |
0.815 | -0.093 | -2 | 0.752 |
CHK1 |
0.815 | -0.045 | -3 | 0.820 |
GSK3B |
0.813 | 0.052 | 4 | 0.513 |
PLK3 |
0.813 | -0.113 | 2 | 0.794 |
MEKK3 |
0.813 | -0.102 | 1 | 0.746 |
BRAF |
0.813 | -0.087 | -4 | 0.763 |
MAK |
0.813 | 0.191 | -2 | 0.743 |
DCAMKL1 |
0.813 | -0.026 | -3 | 0.773 |
CAMK1G |
0.813 | -0.061 | -3 | 0.759 |
CK1G1 |
0.812 | 0.089 | -3 | 0.678 |
MEKK1 |
0.812 | -0.105 | 1 | 0.754 |
CK1A2 |
0.812 | 0.124 | -3 | 0.643 |
MEK5 |
0.812 | -0.182 | 2 | 0.843 |
MARK1 |
0.812 | -0.075 | 4 | 0.806 |
ZAK |
0.812 | -0.096 | 1 | 0.718 |
TLK2 |
0.811 | -0.124 | 1 | 0.725 |
SSTK |
0.811 | 0.005 | 4 | 0.829 |
NEK5 |
0.811 | -0.057 | 1 | 0.776 |
GAK |
0.811 | 0.110 | 1 | 0.830 |
MEKK2 |
0.811 | -0.061 | 2 | 0.825 |
TAO3 |
0.811 | -0.001 | 1 | 0.746 |
WNK4 |
0.810 | -0.104 | -2 | 0.882 |
CDK6 |
0.810 | 0.155 | 1 | 0.688 |
PERK |
0.810 | -0.146 | -2 | 0.798 |
SNRK |
0.809 | -0.198 | 2 | 0.692 |
IRAK4 |
0.809 | -0.076 | 1 | 0.733 |
DYRK3 |
0.809 | 0.066 | 1 | 0.727 |
PINK1 |
0.809 | -0.152 | 1 | 0.793 |
ERK7 |
0.809 | 0.084 | 2 | 0.586 |
AKT1 |
0.807 | 0.018 | -3 | 0.696 |
PKCT |
0.807 | -0.026 | 2 | 0.765 |
HRI |
0.807 | -0.192 | -2 | 0.793 |
PKACA |
0.807 | 0.006 | -2 | 0.585 |
CK2A1 |
0.806 | 0.114 | 1 | 0.695 |
GRK3 |
0.806 | -0.008 | -2 | 0.678 |
SMMLCK |
0.806 | -0.072 | -3 | 0.818 |
GCK |
0.806 | 0.058 | 1 | 0.748 |
P70S6K |
0.806 | -0.032 | -3 | 0.705 |
PKCE |
0.806 | 0.037 | 2 | 0.766 |
EEF2K |
0.805 | 0.080 | 3 | 0.866 |
MAPKAPK5 |
0.805 | -0.160 | -3 | 0.737 |
CDK4 |
0.805 | 0.132 | 1 | 0.667 |
PKCI |
0.805 | -0.029 | 2 | 0.781 |
CAMKK1 |
0.804 | -0.103 | -2 | 0.774 |
CAMKK2 |
0.804 | -0.074 | -2 | 0.772 |
PLK4 |
0.804 | -0.159 | 2 | 0.637 |
LKB1 |
0.803 | -0.033 | -3 | 0.872 |
PDK1 |
0.803 | -0.040 | 1 | 0.772 |
TAO2 |
0.803 | -0.050 | 2 | 0.874 |
TLK1 |
0.803 | -0.140 | -2 | 0.783 |
PDHK3_TYR |
0.803 | 0.280 | 4 | 0.908 |
DAPK3 |
0.803 | -0.005 | -3 | 0.800 |
MST2 |
0.802 | -0.035 | 1 | 0.761 |
DCAMKL2 |
0.802 | -0.081 | -3 | 0.789 |
NEK11 |
0.801 | -0.147 | 1 | 0.747 |
TAK1 |
0.801 | -0.006 | 1 | 0.770 |
TNIK |
0.801 | 0.069 | 3 | 0.863 |
NEK8 |
0.801 | -0.133 | 2 | 0.840 |
HPK1 |
0.801 | 0.023 | 1 | 0.733 |
MINK |
0.801 | 0.014 | 1 | 0.734 |
CAMK1D |
0.800 | -0.034 | -3 | 0.666 |
TTBK1 |
0.800 | -0.157 | 2 | 0.658 |
HGK |
0.800 | 0.014 | 3 | 0.863 |
MOK |
0.800 | 0.121 | 1 | 0.735 |
PHKG2 |
0.799 | -0.088 | -3 | 0.784 |
AKT3 |
0.798 | 0.037 | -3 | 0.611 |
LRRK2 |
0.798 | -0.070 | 2 | 0.867 |
SGK1 |
0.798 | 0.031 | -3 | 0.596 |
PBK |
0.798 | 0.086 | 1 | 0.766 |
KHS1 |
0.798 | 0.074 | 1 | 0.726 |
DAPK1 |
0.797 | -0.020 | -3 | 0.786 |
MAP3K15 |
0.797 | -0.044 | 1 | 0.708 |
PKN1 |
0.797 | -0.017 | -3 | 0.718 |
KHS2 |
0.797 | 0.090 | 1 | 0.738 |
NEK4 |
0.795 | -0.127 | 1 | 0.731 |
PAK5 |
0.795 | -0.064 | -2 | 0.627 |
IRAK1 |
0.794 | -0.273 | -1 | 0.670 |
MEKK6 |
0.794 | -0.111 | 1 | 0.728 |
ROCK2 |
0.794 | 0.031 | -3 | 0.784 |
MRCKA |
0.794 | -0.005 | -3 | 0.749 |
PAK4 |
0.793 | -0.042 | -2 | 0.625 |
PDHK4_TYR |
0.792 | 0.105 | 2 | 0.892 |
TESK1_TYR |
0.792 | 0.060 | 3 | 0.858 |
BUB1 |
0.792 | 0.090 | -5 | 0.790 |
LOK |
0.792 | -0.056 | -2 | 0.761 |
NEK1 |
0.791 | -0.082 | 1 | 0.741 |
MRCKB |
0.791 | -0.005 | -3 | 0.726 |
MST1 |
0.791 | -0.081 | 1 | 0.735 |
MAP2K4_TYR |
0.791 | 0.034 | -1 | 0.811 |
MAP2K6_TYR |
0.791 | 0.055 | -1 | 0.817 |
VRK1 |
0.790 | -0.127 | 2 | 0.853 |
SLK |
0.790 | -0.058 | -2 | 0.717 |
PLK2 |
0.790 | -0.061 | -3 | 0.781 |
STK33 |
0.790 | -0.139 | 2 | 0.642 |
PKMYT1_TYR |
0.790 | 0.024 | 3 | 0.834 |
PDHK1_TYR |
0.788 | 0.030 | -1 | 0.833 |
CHK2 |
0.788 | -0.042 | -3 | 0.613 |
SBK |
0.787 | 0.006 | -3 | 0.543 |
BMPR2_TYR |
0.787 | 0.001 | -1 | 0.805 |
YSK1 |
0.786 | -0.066 | 2 | 0.834 |
MAP2K7_TYR |
0.786 | -0.142 | 2 | 0.878 |
DMPK1 |
0.786 | 0.036 | -3 | 0.741 |
CAMK1A |
0.785 | -0.039 | -3 | 0.631 |
LIMK2_TYR |
0.784 | 0.027 | -3 | 0.896 |
EPHA6 |
0.784 | 0.067 | -1 | 0.802 |
HASPIN |
0.783 | 0.028 | -1 | 0.631 |
YANK3 |
0.782 | -0.005 | 2 | 0.427 |
MEK2 |
0.781 | -0.267 | 2 | 0.826 |
PINK1_TYR |
0.781 | -0.181 | 1 | 0.799 |
CK1A |
0.781 | 0.092 | -3 | 0.561 |
FGR |
0.781 | 0.068 | 1 | 0.823 |
RIPK2 |
0.780 | -0.281 | 1 | 0.690 |
EPHB4 |
0.779 | 0.031 | -1 | 0.785 |
OSR1 |
0.779 | -0.047 | 2 | 0.817 |
CRIK |
0.778 | 0.020 | -3 | 0.694 |
ALPHAK3 |
0.778 | -0.004 | -1 | 0.703 |
BIKE |
0.777 | 0.070 | 1 | 0.735 |
YES1 |
0.776 | 0.011 | -1 | 0.796 |
ROCK1 |
0.776 | -0.024 | -3 | 0.743 |
LIMK1_TYR |
0.775 | -0.157 | 2 | 0.872 |
TXK |
0.775 | 0.066 | 1 | 0.822 |
MYO3B |
0.775 | -0.030 | 2 | 0.848 |
TTK |
0.775 | -0.081 | -2 | 0.752 |
ROS1 |
0.774 | -0.067 | 3 | 0.745 |
RET |
0.774 | -0.135 | 1 | 0.750 |
BLK |
0.773 | 0.090 | -1 | 0.780 |
MST1R |
0.773 | -0.128 | 3 | 0.764 |
TYRO3 |
0.773 | -0.097 | 3 | 0.769 |
NEK3 |
0.773 | -0.195 | 1 | 0.701 |
HCK |
0.773 | -0.003 | -1 | 0.769 |
LCK |
0.772 | 0.060 | -1 | 0.775 |
ASK1 |
0.772 | -0.130 | 1 | 0.701 |
EPHA4 |
0.772 | 0.001 | 2 | 0.796 |
PKG1 |
0.772 | -0.079 | -2 | 0.563 |
DDR1 |
0.771 | -0.158 | 4 | 0.842 |
TNNI3K_TYR |
0.771 | 0.040 | 1 | 0.761 |
ABL2 |
0.771 | -0.020 | -1 | 0.748 |
TYK2 |
0.771 | -0.183 | 1 | 0.750 |
TNK2 |
0.771 | -0.022 | 3 | 0.693 |
MYO3A |
0.771 | -0.065 | 1 | 0.711 |
CSF1R |
0.770 | -0.087 | 3 | 0.757 |
FER |
0.769 | -0.108 | 1 | 0.858 |
SRMS |
0.769 | -0.039 | 1 | 0.832 |
JAK2 |
0.769 | -0.153 | 1 | 0.750 |
ABL1 |
0.769 | -0.035 | -1 | 0.741 |
FYN |
0.768 | 0.065 | -1 | 0.755 |
JAK3 |
0.768 | -0.102 | 1 | 0.736 |
TAO1 |
0.768 | -0.098 | 1 | 0.668 |
EPHB1 |
0.767 | -0.053 | 1 | 0.822 |
ITK |
0.767 | -0.046 | -1 | 0.728 |
EPHB2 |
0.767 | -0.018 | -1 | 0.771 |
INSRR |
0.766 | -0.112 | 3 | 0.713 |
EPHB3 |
0.766 | -0.045 | -1 | 0.768 |
FGFR2 |
0.763 | -0.141 | 3 | 0.758 |
KDR |
0.763 | -0.092 | 3 | 0.727 |
AAK1 |
0.763 | 0.120 | 1 | 0.645 |
BMX |
0.761 | -0.047 | -1 | 0.649 |
JAK1 |
0.761 | -0.061 | 1 | 0.695 |
KIT |
0.761 | -0.138 | 3 | 0.758 |
EPHA7 |
0.761 | -0.039 | 2 | 0.794 |
TEK |
0.761 | -0.142 | 3 | 0.703 |
TNK1 |
0.760 | -0.097 | 3 | 0.749 |
MERTK |
0.760 | -0.088 | 3 | 0.730 |
PDGFRB |
0.760 | -0.195 | 3 | 0.767 |
FLT3 |
0.758 | -0.179 | 3 | 0.769 |
WEE1_TYR |
0.758 | -0.091 | -1 | 0.659 |
FGFR1 |
0.758 | -0.161 | 3 | 0.723 |
LYN |
0.758 | -0.043 | 3 | 0.715 |
BTK |
0.758 | -0.160 | -1 | 0.694 |
TEC |
0.758 | -0.093 | -1 | 0.661 |
NEK10_TYR |
0.758 | -0.154 | 1 | 0.625 |
EPHA3 |
0.757 | -0.102 | 2 | 0.769 |
CK1G3 |
0.757 | 0.068 | -3 | 0.516 |
FLT1 |
0.757 | -0.092 | -1 | 0.794 |
AXL |
0.756 | -0.164 | 3 | 0.727 |
SRC |
0.756 | -0.020 | -1 | 0.753 |
MET |
0.756 | -0.122 | 3 | 0.721 |
FRK |
0.755 | -0.081 | -1 | 0.781 |
PDGFRA |
0.755 | -0.225 | 3 | 0.773 |
ERBB2 |
0.755 | -0.150 | 1 | 0.724 |
DDR2 |
0.754 | -0.044 | 3 | 0.696 |
ALK |
0.754 | -0.157 | 3 | 0.674 |
STLK3 |
0.754 | -0.219 | 1 | 0.685 |
LTK |
0.754 | -0.151 | 3 | 0.704 |
PTK6 |
0.753 | -0.211 | -1 | 0.664 |
NTRK1 |
0.752 | -0.215 | -1 | 0.767 |
EPHA5 |
0.752 | -0.054 | 2 | 0.779 |
FGFR3 |
0.752 | -0.157 | 3 | 0.727 |
PTK2 |
0.752 | 0.012 | -1 | 0.749 |
SYK |
0.751 | 0.043 | -1 | 0.735 |
EPHA1 |
0.751 | -0.134 | 3 | 0.697 |
PTK2B |
0.750 | -0.090 | -1 | 0.710 |
FLT4 |
0.750 | -0.184 | 3 | 0.745 |
INSR |
0.749 | -0.178 | 3 | 0.691 |
NTRK2 |
0.749 | -0.234 | 3 | 0.730 |
EPHA8 |
0.748 | -0.096 | -1 | 0.745 |
EGFR |
0.748 | -0.082 | 1 | 0.643 |
YANK2 |
0.747 | -0.037 | 2 | 0.445 |
MATK |
0.747 | -0.133 | -1 | 0.677 |
NTRK3 |
0.747 | -0.168 | -1 | 0.724 |
CK1G2 |
0.741 | 0.055 | -3 | 0.605 |
CSK |
0.740 | -0.187 | 2 | 0.797 |
ERBB4 |
0.739 | -0.044 | 1 | 0.676 |
FGFR4 |
0.739 | -0.138 | -1 | 0.724 |
EPHA2 |
0.738 | -0.098 | -1 | 0.724 |
IGF1R |
0.734 | -0.180 | 3 | 0.638 |
MUSK |
0.732 | -0.174 | 1 | 0.624 |
ZAP70 |
0.724 | -0.028 | -1 | 0.636 |
FES |
0.723 | -0.179 | -1 | 0.628 |