Motif 508 (n=154)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A8CG34 | POM121C | S165 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| B8ZZF3 | None | S330 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| E7EW31 | PROB1 | T823 | ochoa | Proline-rich basic protein 1 | None |
| O00221 | NFKBIE | S180 | ochoa | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}. |
| O00267 | SUPT5H | S866 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00423 | EML1 | S113 | ochoa | Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) | Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}. |
| O00499 | BIN1 | S286 | ochoa | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). {ECO:0000250|UniProtKB:O08839, ECO:0000269|PubMed:24755653, ECO:0000269|PubMed:27179792, ECO:0000269|PubMed:28893863, ECO:0000269|PubMed:8782822}. |
| O00512 | BCL9 | S157 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14497 | ARID1A | S381 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14523 | C2CD2L | S380 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14686 | KMT2D | S2239 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15117 | FYB1 | S52 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15357 | INPPL1 | S1011 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O15357 | INPPL1 | S1160 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O15438 | ABCC3 | S281 | ochoa | ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000305|PubMed:35307651}. |
| O43237 | DYNC1LI2 | S389 | ochoa | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}. |
| O43561 | LAT | S131 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O60934 | NBN | S343 | ochoa|psp | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75146 | HIP1R | S1027 | ochoa | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}. |
| O75533 | SF3B1 | S217 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75665 | OFD1 | S774 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75674 | TOM1L1 | S311 | ochoa | TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) | Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}. |
| O76021 | RSL1D1 | S400 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O94868 | FCHSD2 | S652 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94885 | SASH1 | S1054 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95402 | MED26 | S322 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95782 | AP2A1 | S657 | ochoa | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| O95997 | PTTG1 | S171 | ochoa|psp | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}. |
| O96013 | PAK4 | S258 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P10398 | ARAF | S259 | ochoa|psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P12259 | F5 | S912 | ochoa | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| P12524 | MYCL | S38 | psp | Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) | None |
| P12931 | SRC | S39 | psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P15822 | HIVEP1 | S698 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P19634 | SLC9A1 | S787 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P27708 | CAD | S1823 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P29353 | SHC1 | S388 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P29590 | PML | S30 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P35611 | ADD1 | S613 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P40222 | TXLNA | S514 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P43243 | MATR3 | S275 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46821 | MAP1B | S1324 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47974 | ZFP36L2 | S414 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48681 | NES | S358 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49006 | MARCKSL1 | S177 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49418 | AMPH | S272 | ochoa|psp | Amphiphysin | May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. |
| P50616 | TOB1 | S154 | ochoa|psp | Protein Tob1 (Transducer of erbB-2 1) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}. |
| P51610 | HCFC1 | S419 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P51610 | HCFC1 | S1497 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P56945 | BCAR1 | S260 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P57086 | SCAND1 | S51 | ochoa | SCAN domain-containing protein 1 | May regulate transcriptional activity. |
| P78559 | MAP1A | S1812 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78559 | MAP1A | S2237 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q02078 | MEF2A | S201 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q03164 | KMT2A | S3517 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q12802 | AKAP13 | S2699 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13835 | PKP1 | S205 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14451 | GRB7 | S66 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14511 | NEDD9 | S182 | ochoa | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q14676 | MDC1 | S1130 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1171 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1212 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1335 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1376 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1417 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1458 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1499 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1540 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1581 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1622 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15428 | SF3A2 | S222 | ochoa | Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310}. |
| Q15648 | MED1 | S795 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q3KQU3 | MAP7D1 | S34 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q5SYE7 | NHSL1 | S1181 | ochoa | NHS-like protein 1 | None |
| Q5T5P2 | KIAA1217 | S316 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q68EM7 | ARHGAP17 | S560 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6F5E8 | CARMIL2 | S1395 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6NV74 | CRACDL | S333 | ochoa | CRACD-like protein | None |
| Q6NXT4 | SLC30A6 | S381 | ochoa | Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) | Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15994300, PubMed:19759014, PubMed:35525268). {ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:19759014, ECO:0000269|PubMed:35525268}. |
| Q6PJ61 | FBXO46 | S280 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6PKG0 | LARP1 | S761 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZU65 | UBN2 | S1058 | ochoa | Ubinuclein-2 | None |
| Q6ZW31 | SYDE1 | S244 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q7KZI7 | MARK2 | S559 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L591 | DOK3 | S333 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7RTP6 | MICAL3 | S1300 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z434 | MAVS | S139 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q86YV5 | PRAG1 | S798 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IVF2 | AHNAK2 | S5515 | ochoa | Protein AHNAK2 | None |
| Q8IWU2 | LMTK2 | S1126 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IXI1 | RHOT2 | S538 | ochoa | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8IYB3 | SRRM1 | S717 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZL8 | PELP1 | S1033 | ochoa|psp | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N137 | CNTROB | S743 | ochoa | Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}. |
| Q8NC96 | NECAP1 | S201 | ochoa | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | Involved in endocytosis. {ECO:0000250}. |
| Q8ND04 | SMG8 | S656 | ochoa | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}. |
| Q8NDX1 | PSD4 | S447 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8TD08 | MAPK15 | S379 | psp | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q8TDZ2 | MICAL1 | S774 | ochoa | [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250|UniProtKB:Q8VDP3, ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000269|PubMed:26845023, ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:32344433, ECO:0000305|PubMed:27552051}. |
| Q8WUF5 | PPP1R13L | S65 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WVT3 | TRAPPC12 | S109 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q8WXE0 | CASKIN2 | S358 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WXH0 | SYNE2 | S6779 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WYP5 | AHCTF1 | S1647 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q96AP7 | ESAM | S344 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
| Q96EZ8 | MCRS1 | S90 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
| Q96II8 | LRCH3 | S582 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96IZ7 | RSRC1 | S278 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
| Q96JM3 | CHAMP1 | S177 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96MG2 | JSRP1 | S166 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96PK6 | RBM14 | S242 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PK6 | RBM14 | S254 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PU5 | NEDD4L | S377 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96RG2 | PASK | S849 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96T58 | SPEN | S3433 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99459 | CDC5L | S417 | ochoa|psp | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99700 | ATXN2 | S560 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99704 | DOK1 | S281 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q9BRG2 | SH2D3A | S218 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
| Q9BRK4 | LZTS2 | S249 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BTA9 | WAC | S265 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BXH1 | BBC3 | S96 | psp | Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis) | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99ML1, ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}. |
| Q9C0E8 | LNPK | S217 | ochoa | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}. |
| Q9H0F6 | SHARPIN | S146 | ochoa|psp | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9H1K0 | RBSN | S601 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H201 | EPN3 | S448 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H2F5 | EPC1 | S347 | ochoa | Enhancer of polycomb homolog 1 | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
| Q9H3S7 | PTPN23 | S1091 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9H6S0 | YTHDC2 | S1269 | ochoa | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}. |
| Q9HAH7 | FBRS | S351 | ochoa | Probable fibrosin-1 | None |
| Q9HC35 | EML4 | S150 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HCM7 | FBRSL1 | S131 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NQC3 | RTN4 | S111 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQC3 | RTN4 | S171 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQG1 | MANBAL | S55 | ochoa | Protein MANBAL | None |
| Q9NZM4 | BICRA | T921 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
| Q9P206 | NHSL3 | S981 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P246 | STIM2 | S522 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9UBF8 | PI4KB | S256 | ochoa | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}. |
| Q9UER7 | DAXX | S690 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UGP4 | LIMD1 | S210 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHV7 | MED13 | S553 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9UHY1 | NRBP1 | S428 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9ULD4 | BRPF3 | S792 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9UMN6 | KMT2B | S500 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMS4 | PRPF19 | S148 | ochoa | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). {ECO:0000250|UniProtKB:Q99KP6, ECO:0000250|UniProtKB:Q9JMJ4, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO:0000269|PubMed:15660529, ECO:0000269|PubMed:16223718, ECO:0000269|PubMed:16332694, ECO:0000269|PubMed:16388800, ECO:0000269|PubMed:17349974, ECO:0000269|PubMed:18263876, ECO:0000269|PubMed:21536736, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154, ECO:0000303|PubMed:17981804, ECO:0000303|PubMed:20595234}. |
| Q9UPN9 | TRIM33 | S634 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UPT8 | ZC3H4 | S165 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UPT8 | ZC3H4 | S1069 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9Y490 | TLN1 | S45 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4F5 | CEP170B | S1057 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4U1 | MMACHC | S244 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
| Q8TD08 | MAPK15 | S311 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q9UM73 | ALK | S1427 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.000206 | 3.686 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.000206 | 3.686 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.000206 | 3.686 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.000206 | 3.686 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.000206 | 3.686 |
| R-HSA-354192 | Integrin signaling | 0.000058 | 4.237 |
| R-HSA-201556 | Signaling by ALK | 0.000125 | 3.904 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000082 | 4.087 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.000239 | 3.621 |
| R-HSA-4839726 | Chromatin organization | 0.000506 | 3.296 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.000485 | 3.314 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.000639 | 3.194 |
| R-HSA-9842663 | Signaling by LTK | 0.000639 | 3.194 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.000666 | 3.177 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.000736 | 3.133 |
| R-HSA-8853659 | RET signaling | 0.001076 | 2.968 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.001337 | 2.874 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.001589 | 2.799 |
| R-HSA-166520 | Signaling by NTRKs | 0.001747 | 2.758 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.002129 | 2.672 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.002830 | 2.548 |
| R-HSA-9634597 | GPER1 signaling | 0.002793 | 2.554 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.003030 | 2.519 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.004879 | 2.312 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.004942 | 2.306 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.005726 | 2.242 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.006274 | 2.202 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.006932 | 2.159 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.006932 | 2.159 |
| R-HSA-186763 | Downstream signal transduction | 0.006762 | 2.170 |
| R-HSA-9833110 | RSV-host interactions | 0.007197 | 2.143 |
| R-HSA-9700649 | Drug resistance of ALK mutants | 0.010195 | 1.992 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 0.010195 | 1.992 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 0.010195 | 1.992 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 0.010195 | 1.992 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 0.010195 | 1.992 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 0.010195 | 1.992 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 0.010195 | 1.992 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 0.010195 | 1.992 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.009310 | 2.031 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.010616 | 1.974 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.008932 | 2.049 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.010797 | 1.967 |
| R-HSA-74160 | Gene expression (Transcription) | 0.011365 | 1.944 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.010797 | 1.967 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.011382 | 1.944 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.012283 | 1.911 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.012003 | 1.921 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.012487 | 1.904 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.014372 | 1.842 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.014372 | 1.842 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.013610 | 1.866 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.014985 | 1.824 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.018256 | 1.739 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.018541 | 1.732 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.018541 | 1.732 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.018541 | 1.732 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.018541 | 1.732 |
| R-HSA-75153 | Apoptotic execution phase | 0.018541 | 1.732 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.015968 | 1.797 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.017659 | 1.753 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.021869 | 1.660 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.023219 | 1.634 |
| R-HSA-210993 | Tie2 Signaling | 0.023668 | 1.626 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.023668 | 1.626 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.025827 | 1.588 |
| R-HSA-72172 | mRNA Splicing | 0.028711 | 1.542 |
| R-HSA-3214847 | HATs acetylate histones | 0.027296 | 1.564 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.028886 | 1.539 |
| R-HSA-177929 | Signaling by EGFR | 0.028685 | 1.542 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.028685 | 1.542 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.029651 | 1.528 |
| R-HSA-167044 | Signalling to RAS | 0.029651 | 1.528 |
| R-HSA-3359473 | Defective MMADHC causes MMAHCD | 0.030275 | 1.519 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.031765 | 1.498 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.036165 | 1.442 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.038448 | 1.415 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.034882 | 1.457 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.038526 | 1.414 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.031002 | 1.509 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.030835 | 1.511 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.034882 | 1.457 |
| R-HSA-186797 | Signaling by PDGF | 0.035924 | 1.445 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.037213 | 1.429 |
| R-HSA-8848021 | Signaling by PTK6 | 0.037213 | 1.429 |
| R-HSA-1640170 | Cell Cycle | 0.037859 | 1.422 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.037260 | 1.429 |
| R-HSA-212436 | Generic Transcription Pathway | 0.031626 | 1.500 |
| R-HSA-109581 | Apoptosis | 0.038780 | 1.411 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.039863 | 1.399 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.040785 | 1.390 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.040785 | 1.390 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.043174 | 1.365 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.044012 | 1.356 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.040980 | 1.387 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.045248 | 1.344 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.039863 | 1.399 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.043174 | 1.365 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.042116 | 1.376 |
| R-HSA-525793 | Myogenesis | 0.043174 | 1.365 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.045308 | 1.344 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.045613 | 1.341 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.045613 | 1.341 |
| R-HSA-3359474 | Defective MMACHC causes MAHCC | 0.049950 | 1.301 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.049950 | 1.301 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.049950 | 1.301 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.059638 | 1.224 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.053226 | 1.274 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.055858 | 1.253 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.055858 | 1.253 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.061253 | 1.213 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.061253 | 1.213 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.064015 | 1.194 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.069663 | 1.157 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.051384 | 1.289 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.066048 | 1.180 |
| R-HSA-191650 | Regulation of gap junction activity | 0.059638 | 1.224 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 0.059638 | 1.224 |
| R-HSA-2424491 | DAP12 signaling | 0.053226 | 1.274 |
| R-HSA-5673000 | RAF activation | 0.066819 | 1.175 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.069228 | 1.160 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.058534 | 1.233 |
| R-HSA-9930044 | Nuclear RNA decay | 0.061253 | 1.213 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.064015 | 1.194 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.061253 | 1.213 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.066819 | 1.175 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.053226 | 1.274 |
| R-HSA-187687 | Signalling to ERKs | 0.069663 | 1.157 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.050641 | 1.295 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.053226 | 1.274 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.069663 | 1.157 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.069663 | 1.157 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.050326 | 1.298 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.058534 | 1.233 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.062639 | 1.203 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.060527 | 1.218 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.053226 | 1.274 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.058534 | 1.233 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.071318 | 1.147 |
| R-HSA-9609690 | HCMV Early Events | 0.071510 | 1.146 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.072545 | 1.139 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.078721 | 1.104 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.097419 | 1.011 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.106626 | 0.972 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.106626 | 0.972 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.133691 | 0.874 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.142531 | 0.846 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.159941 | 0.796 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.159941 | 0.796 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.168514 | 0.773 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.177000 | 0.752 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.193715 | 0.713 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.081418 | 1.089 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.084446 | 1.073 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.084446 | 1.073 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.218156 | 0.661 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.218156 | 0.661 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.226139 | 0.646 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.226139 | 0.646 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.226139 | 0.646 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.226139 | 0.646 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.226139 | 0.646 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.272360 | 0.565 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.287149 | 0.542 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.287149 | 0.542 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.294431 | 0.531 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.294431 | 0.531 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.220530 | 0.657 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.250656 | 0.601 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.250656 | 0.601 |
| R-HSA-1989781 | PPARA activates gene expression | 0.261735 | 0.582 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.267238 | 0.573 |
| R-HSA-3928664 | Ephrin signaling | 0.210092 | 0.678 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.279792 | 0.553 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.231800 | 0.635 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.124761 | 0.904 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.097419 | 1.011 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.128623 | 0.891 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.142531 | 0.846 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.174295 | 0.759 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.174295 | 0.759 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.177000 | 0.752 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.193715 | 0.713 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.287149 | 0.542 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.179735 | 0.745 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.286595 | 0.543 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.150906 | 0.821 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.174295 | 0.759 |
| R-HSA-202433 | Generation of second messenger molecules | 0.084446 | 1.073 |
| R-HSA-8849473 | PTK6 Expression | 0.097419 | 1.011 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.177000 | 0.752 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.210092 | 0.678 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.109814 | 0.959 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.294431 | 0.531 |
| R-HSA-437239 | Recycling pathway of L1 | 0.109814 | 0.959 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.249603 | 0.603 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.097419 | 1.011 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.168514 | 0.773 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.177000 | 0.752 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.279792 | 0.553 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.287149 | 0.542 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.294431 | 0.531 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.129974 | 0.886 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.193715 | 0.713 |
| R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.287149 | 0.542 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.098249 | 1.008 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.096890 | 1.014 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.106626 | 0.972 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.124761 | 0.904 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.151280 | 0.820 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.151280 | 0.820 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.075466 | 1.122 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.103296 | 0.986 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.264852 | 0.577 |
| R-HSA-5689603 | UCH proteinases | 0.213043 | 0.672 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.280896 | 0.551 |
| R-HSA-68877 | Mitotic Prometaphase | 0.174148 | 0.759 |
| R-HSA-74749 | Signal attenuation | 0.124761 | 0.904 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.218156 | 0.661 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.106626 | 0.972 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.133691 | 0.874 |
| R-HSA-8851805 | MET activates RAS signaling | 0.151280 | 0.820 |
| R-HSA-171007 | p38MAPK events | 0.177000 | 0.752 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.185400 | 0.732 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.201945 | 0.695 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.226139 | 0.646 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.115740 | 0.937 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.168514 | 0.773 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.083373 | 1.079 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.218156 | 0.661 |
| R-HSA-2172127 | DAP12 interactions | 0.100078 | 1.000 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.151280 | 0.820 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.234040 | 0.631 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.150906 | 0.821 |
| R-HSA-191859 | snRNP Assembly | 0.150906 | 0.821 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.158025 | 0.801 |
| R-HSA-68882 | Mitotic Anaphase | 0.224177 | 0.649 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.113113 | 0.946 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.264852 | 0.577 |
| R-HSA-9843745 | Adipogenesis | 0.192148 | 0.716 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.226340 | 0.645 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.257266 | 0.590 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.087509 | 1.058 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.249603 | 0.603 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.210092 | 0.678 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.097419 | 1.011 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.097419 | 1.011 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.106626 | 0.972 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.106626 | 0.972 |
| R-HSA-428540 | Activation of RAC1 | 0.142531 | 0.846 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.084446 | 1.073 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.084446 | 1.073 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.087509 | 1.058 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.129974 | 0.886 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.272360 | 0.565 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.205582 | 0.687 |
| R-HSA-162587 | HIV Life Cycle | 0.106551 | 0.972 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.226139 | 0.646 |
| R-HSA-68886 | M Phase | 0.121943 | 0.914 |
| R-HSA-162906 | HIV Infection | 0.111436 | 0.953 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.084446 | 1.073 |
| R-HSA-8953854 | Metabolism of RNA | 0.102269 | 0.990 |
| R-HSA-9609646 | HCMV Infection | 0.145545 | 0.837 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.115740 | 0.937 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.201945 | 0.695 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.201945 | 0.695 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.272360 | 0.565 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.093732 | 1.028 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.198151 | 0.703 |
| R-HSA-199991 | Membrane Trafficking | 0.249053 | 0.604 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.169285 | 0.771 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.106626 | 0.972 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.115740 | 0.937 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.078424 | 1.106 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.106541 | 0.972 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.257266 | 0.590 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.257266 | 0.590 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.198151 | 0.703 |
| R-HSA-422475 | Axon guidance | 0.226027 | 0.646 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.279792 | 0.553 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.084873 | 1.071 |
| R-HSA-1500620 | Meiosis | 0.246880 | 0.608 |
| R-HSA-73887 | Death Receptor Signaling | 0.258990 | 0.587 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.279792 | 0.553 |
| R-HSA-114608 | Platelet degranulation | 0.179347 | 0.746 |
| R-HSA-9675108 | Nervous system development | 0.278707 | 0.555 |
| R-HSA-418555 | G alpha (s) signalling events | 0.132312 | 0.878 |
| R-HSA-449836 | Other interleukin signaling | 0.218156 | 0.661 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.234040 | 0.631 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.234040 | 0.631 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.083373 | 1.079 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.193715 | 0.713 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.081418 | 1.089 |
| R-HSA-2160916 | Hyaluronan degradation | 0.272360 | 0.565 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.228038 | 0.642 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.231800 | 0.635 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.241861 | 0.616 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.143853 | 0.842 |
| R-HSA-8964038 | LDL clearance | 0.249603 | 0.603 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.106626 | 0.972 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.124761 | 0.904 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.124761 | 0.904 |
| R-HSA-210990 | PECAM1 interactions | 0.133691 | 0.874 |
| R-HSA-198753 | ERK/MAPK targets | 0.234040 | 0.631 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.249603 | 0.603 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.264852 | 0.577 |
| R-HSA-9620244 | Long-term potentiation | 0.272360 | 0.565 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.161609 | 0.792 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.197333 | 0.705 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.135523 | 0.868 |
| R-HSA-6806834 | Signaling by MET | 0.228038 | 0.642 |
| R-HSA-109582 | Hemostasis | 0.125092 | 0.903 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.097419 | 1.011 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.185400 | 0.732 |
| R-HSA-190236 | Signaling by FGFR | 0.102391 | 0.990 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.250478 | 0.601 |
| R-HSA-162582 | Signal Transduction | 0.108594 | 0.964 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.205582 | 0.687 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.140354 | 0.853 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.161609 | 0.792 |
| R-HSA-9663891 | Selective autophagy | 0.261994 | 0.582 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.255485 | 0.593 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.133691 | 0.874 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.106626 | 0.972 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.115740 | 0.937 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.159941 | 0.796 |
| R-HSA-5357801 | Programmed Cell Death | 0.082989 | 1.081 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.177000 | 0.752 |
| R-HSA-180292 | GAB1 signalosome | 0.210092 | 0.678 |
| R-HSA-9824446 | Viral Infection Pathways | 0.199662 | 0.700 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.272360 | 0.565 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.294431 | 0.531 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.140354 | 0.853 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.294431 | 0.531 |
| R-HSA-8939211 | ESR-mediated signaling | 0.125746 | 0.901 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.209309 | 0.679 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.270622 | 0.568 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.275516 | 0.560 |
| R-HSA-201451 | Signaling by BMP | 0.287149 | 0.542 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.193715 | 0.713 |
| R-HSA-2262752 | Cellular responses to stress | 0.180178 | 0.744 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.258990 | 0.587 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.241861 | 0.616 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.209309 | 0.679 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.301639 | 0.521 |
| R-HSA-72086 | mRNA Capping | 0.301639 | 0.521 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.301639 | 0.521 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.301639 | 0.521 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.301639 | 0.521 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.301639 | 0.521 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.301639 | 0.521 |
| R-HSA-157579 | Telomere Maintenance | 0.303526 | 0.518 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.303526 | 0.518 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.308645 | 0.511 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.308774 | 0.510 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.308774 | 0.510 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.308774 | 0.510 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.311045 | 0.507 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.311045 | 0.507 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.314799 | 0.502 |
| R-HSA-70171 | Glycolysis | 0.314799 | 0.502 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.315836 | 0.501 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.315836 | 0.501 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.315836 | 0.501 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.315836 | 0.501 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.315836 | 0.501 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.318577 | 0.497 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.322292 | 0.492 |
| R-HSA-1483255 | PI Metabolism | 0.322292 | 0.492 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.329747 | 0.482 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.329747 | 0.482 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.329747 | 0.482 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.329747 | 0.482 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.329747 | 0.482 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.329747 | 0.482 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.329747 | 0.482 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.329766 | 0.482 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.336596 | 0.473 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.336596 | 0.473 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.336596 | 0.473 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.336596 | 0.473 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.337216 | 0.472 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.342325 | 0.466 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.343376 | 0.464 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.343376 | 0.464 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.343376 | 0.464 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.343376 | 0.464 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.343376 | 0.464 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.343376 | 0.464 |
| R-HSA-392518 | Signal amplification | 0.343376 | 0.464 |
| R-HSA-5205647 | Mitophagy | 0.343376 | 0.464 |
| R-HSA-211000 | Gene Silencing by RNA | 0.344643 | 0.463 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.350087 | 0.456 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.350087 | 0.456 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.350087 | 0.456 |
| R-HSA-73894 | DNA Repair | 0.350144 | 0.456 |
| R-HSA-202403 | TCR signaling | 0.355732 | 0.449 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.356213 | 0.448 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.356730 | 0.448 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.356730 | 0.448 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.356730 | 0.448 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.363088 | 0.440 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.363305 | 0.440 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.363305 | 0.440 |
| R-HSA-1266738 | Developmental Biology | 0.365417 | 0.437 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.369814 | 0.432 |
| R-HSA-8875878 | MET promotes cell motility | 0.369814 | 0.432 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.370413 | 0.431 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.376256 | 0.425 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.376256 | 0.425 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.376256 | 0.425 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.376256 | 0.425 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.376256 | 0.425 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.377704 | 0.423 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.381337 | 0.419 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.381337 | 0.419 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.382633 | 0.417 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.382633 | 0.417 |
| R-HSA-167169 | HIV Transcription Elongation | 0.382633 | 0.417 |
| R-HSA-9646399 | Aggrephagy | 0.382633 | 0.417 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.382633 | 0.417 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.382633 | 0.417 |
| R-HSA-373760 | L1CAM interactions | 0.384961 | 0.415 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.388576 | 0.411 |
| R-HSA-70326 | Glucose metabolism | 0.388576 | 0.411 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.388945 | 0.410 |
| R-HSA-5693538 | Homology Directed Repair | 0.392182 | 0.407 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.395193 | 0.403 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.395778 | 0.403 |
| R-HSA-913531 | Interferon Signaling | 0.398752 | 0.399 |
| R-HSA-68875 | Mitotic Prophase | 0.399365 | 0.399 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.401377 | 0.396 |
| R-HSA-73928 | Depyrimidination | 0.401377 | 0.396 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.402941 | 0.395 |
| R-HSA-73886 | Chromosome Maintenance | 0.402941 | 0.395 |
| R-HSA-3371556 | Cellular response to heat stress | 0.402941 | 0.395 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.402941 | 0.395 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.407499 | 0.390 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.410064 | 0.387 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.410064 | 0.387 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.410064 | 0.387 |
| R-HSA-195721 | Signaling by WNT | 0.411022 | 0.386 |
| R-HSA-373752 | Netrin-1 signaling | 0.413558 | 0.383 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.413558 | 0.383 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.413558 | 0.383 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.413558 | 0.383 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.413558 | 0.383 |
| R-HSA-69236 | G1 Phase | 0.413558 | 0.383 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.419556 | 0.377 |
| R-HSA-194138 | Signaling by VEGF | 0.420671 | 0.376 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.425493 | 0.371 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.425493 | 0.371 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.425493 | 0.371 |
| R-HSA-9675135 | Diseases of DNA repair | 0.425493 | 0.371 |
| R-HSA-69481 | G2/M Checkpoints | 0.427689 | 0.369 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.431369 | 0.365 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.437186 | 0.359 |
| R-HSA-425410 | Metal ion SLC transporters | 0.437186 | 0.359 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.438132 | 0.358 |
| R-HSA-1474165 | Reproduction | 0.441590 | 0.355 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.442944 | 0.354 |
| R-HSA-9766229 | Degradation of CDH1 | 0.442944 | 0.354 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.447863 | 0.349 |
| R-HSA-9909396 | Circadian clock | 0.448471 | 0.348 |
| R-HSA-1500931 | Cell-Cell communication | 0.451997 | 0.345 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.454284 | 0.343 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.454284 | 0.343 |
| R-HSA-912446 | Meiotic recombination | 0.454284 | 0.343 |
| R-HSA-72187 | mRNA 3'-end processing | 0.459867 | 0.337 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.459867 | 0.337 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.459867 | 0.337 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.459867 | 0.337 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.459867 | 0.337 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.465394 | 0.332 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.465394 | 0.332 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.465394 | 0.332 |
| R-HSA-1221632 | Meiotic synapsis | 0.465394 | 0.332 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.465394 | 0.332 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.470865 | 0.327 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.476280 | 0.322 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.476280 | 0.322 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.476280 | 0.322 |
| R-HSA-9753281 | Paracetamol ADME | 0.476280 | 0.322 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.477912 | 0.321 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.481640 | 0.317 |
| R-HSA-75893 | TNF signaling | 0.481640 | 0.317 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.481640 | 0.317 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.481640 | 0.317 |
| R-HSA-1632852 | Macroautophagy | 0.482148 | 0.317 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.486945 | 0.313 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.492197 | 0.308 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.502540 | 0.299 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.504963 | 0.297 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.507633 | 0.294 |
| R-HSA-450294 | MAP kinase activation | 0.507633 | 0.294 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.512674 | 0.290 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.512674 | 0.290 |
| R-HSA-9707616 | Heme signaling | 0.512674 | 0.290 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.512674 | 0.290 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.514541 | 0.289 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.517663 | 0.286 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.517663 | 0.286 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.517663 | 0.286 |
| R-HSA-373755 | Semaphorin interactions | 0.517663 | 0.286 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.517707 | 0.286 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.520859 | 0.283 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.522602 | 0.282 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.523998 | 0.281 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.524475 | 0.280 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.527491 | 0.278 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.530233 | 0.276 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.532330 | 0.274 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.532330 | 0.274 |
| R-HSA-9612973 | Autophagy | 0.533330 | 0.273 |
| R-HSA-9610379 | HCMV Late Events | 0.536414 | 0.271 |
| R-HSA-5688426 | Deubiquitination | 0.536449 | 0.270 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.537119 | 0.270 |
| R-HSA-9679506 | SARS-CoV Infections | 0.541140 | 0.267 |
| R-HSA-167172 | Transcription of the HIV genome | 0.541860 | 0.266 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.541860 | 0.266 |
| R-HSA-877300 | Interferon gamma signaling | 0.542538 | 0.266 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.551197 | 0.259 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.551197 | 0.259 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.551197 | 0.259 |
| R-HSA-448424 | Interleukin-17 signaling | 0.551197 | 0.259 |
| R-HSA-1643685 | Disease | 0.551684 | 0.258 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.555795 | 0.255 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.555795 | 0.255 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.555795 | 0.255 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.555795 | 0.255 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.560345 | 0.252 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.564850 | 0.248 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.564850 | 0.248 |
| R-HSA-9749641 | Aspirin ADME | 0.564850 | 0.248 |
| R-HSA-5619102 | SLC transporter disorders | 0.566476 | 0.247 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.567698 | 0.246 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.569308 | 0.245 |
| R-HSA-380287 | Centrosome maturation | 0.573721 | 0.241 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.573721 | 0.241 |
| R-HSA-8852135 | Protein ubiquitination | 0.573721 | 0.241 |
| R-HSA-72306 | tRNA processing | 0.578105 | 0.238 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.586677 | 0.232 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.586677 | 0.232 |
| R-HSA-4086400 | PCP/CE pathway | 0.586693 | 0.232 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.586693 | 0.232 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.590929 | 0.228 |
| R-HSA-5663205 | Infectious disease | 0.591616 | 0.228 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.592320 | 0.227 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.595121 | 0.225 |
| R-HSA-9833482 | PKR-mediated signaling | 0.595121 | 0.225 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.595121 | 0.225 |
| R-HSA-168255 | Influenza Infection | 0.603435 | 0.219 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.607445 | 0.216 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.611470 | 0.214 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.611470 | 0.214 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.611470 | 0.214 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.615453 | 0.211 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.619396 | 0.208 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.623299 | 0.205 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.623299 | 0.205 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.627162 | 0.203 |
| R-HSA-1483257 | Phospholipid metabolism | 0.628344 | 0.202 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.628344 | 0.202 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.630986 | 0.200 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.635410 | 0.197 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.638516 | 0.195 |
| R-HSA-73884 | Base Excision Repair | 0.638516 | 0.195 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.648129 | 0.188 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.649527 | 0.187 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.649527 | 0.187 |
| R-HSA-449147 | Signaling by Interleukins | 0.652750 | 0.185 |
| R-HSA-2029481 | FCGR activation | 0.653122 | 0.185 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.656681 | 0.183 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.660204 | 0.180 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.662928 | 0.179 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.665346 | 0.177 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.665346 | 0.177 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.667142 | 0.176 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.667142 | 0.176 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.667142 | 0.176 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.670558 | 0.174 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.673939 | 0.171 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.673939 | 0.171 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.673939 | 0.171 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.673939 | 0.171 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.679098 | 0.168 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.680598 | 0.167 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.680598 | 0.167 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.687122 | 0.163 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.687122 | 0.163 |
| R-HSA-397014 | Muscle contraction | 0.688764 | 0.162 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.688764 | 0.162 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.693513 | 0.159 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.696660 | 0.157 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.696660 | 0.157 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.696660 | 0.157 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.699774 | 0.155 |
| R-HSA-418990 | Adherens junctions interactions | 0.702163 | 0.154 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.702857 | 0.153 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.708929 | 0.149 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.708929 | 0.149 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.711919 | 0.148 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.714878 | 0.146 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.714878 | 0.146 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.714878 | 0.146 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.719400 | 0.143 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.720705 | 0.142 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.720705 | 0.142 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.723575 | 0.141 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.726415 | 0.139 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.729226 | 0.137 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.740185 | 0.131 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.742855 | 0.129 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.745499 | 0.128 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.745499 | 0.128 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.753267 | 0.123 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.753267 | 0.123 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.758314 | 0.120 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.760337 | 0.119 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.765693 | 0.116 |
| R-HSA-421270 | Cell-cell junction organization | 0.767544 | 0.115 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.776290 | 0.110 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.782052 | 0.107 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.793037 | 0.101 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.793037 | 0.101 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.797275 | 0.098 |
| R-HSA-6807070 | PTEN Regulation | 0.799362 | 0.097 |
| R-HSA-168256 | Immune System | 0.799715 | 0.097 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.801427 | 0.096 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.801427 | 0.096 |
| R-HSA-9664407 | Parasite infection | 0.801427 | 0.096 |
| R-HSA-446728 | Cell junction organization | 0.811451 | 0.091 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.815305 | 0.089 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.819090 | 0.087 |
| R-HSA-9758941 | Gastrulation | 0.820953 | 0.086 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.822797 | 0.085 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.836888 | 0.077 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.857448 | 0.067 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.858919 | 0.066 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.860374 | 0.065 |
| R-HSA-1280218 | Adaptive Immune System | 0.861251 | 0.065 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.861814 | 0.065 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.861814 | 0.065 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.863240 | 0.064 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.864651 | 0.063 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.868457 | 0.061 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.868513 | 0.061 |
| R-HSA-8957322 | Metabolism of steroids | 0.869524 | 0.061 |
| R-HSA-2559583 | Cellular Senescence | 0.871492 | 0.060 |
| R-HSA-69275 | G2/M Transition | 0.879249 | 0.056 |
| R-HSA-112316 | Neuronal System | 0.880086 | 0.055 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.881730 | 0.055 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.881730 | 0.055 |
| R-HSA-983712 | Ion channel transport | 0.882951 | 0.054 |
| R-HSA-5617833 | Cilium Assembly | 0.884160 | 0.053 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.887712 | 0.052 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.895586 | 0.048 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.895586 | 0.048 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.898790 | 0.046 |
| R-HSA-6805567 | Keratinization | 0.902910 | 0.044 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.909724 | 0.041 |
| R-HSA-388396 | GPCR downstream signalling | 0.913912 | 0.039 |
| R-HSA-9748784 | Drug ADME | 0.914298 | 0.039 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.924357 | 0.034 |
| R-HSA-72312 | rRNA processing | 0.925915 | 0.033 |
| R-HSA-15869 | Metabolism of nucleotides | 0.928937 | 0.032 |
| R-HSA-597592 | Post-translational protein modification | 0.933482 | 0.030 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.943191 | 0.025 |
| R-HSA-372790 | Signaling by GPCR | 0.949518 | 0.022 |
| R-HSA-9658195 | Leishmania infection | 0.955550 | 0.020 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.955550 | 0.020 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.956012 | 0.020 |
| R-HSA-6798695 | Neutrophil degranulation | 0.958094 | 0.019 |
| R-HSA-168249 | Innate Immune System | 0.970685 | 0.013 |
| R-HSA-382551 | Transport of small molecules | 0.978495 | 0.009 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.981358 | 0.008 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.984890 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.985962 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.986959 | 0.006 |
| R-HSA-418594 | G alpha (i) signalling events | 0.988261 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 0.990491 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.995824 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.999251 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.770 | 0.262 | 1 | 0.839 |
HIPK4 |
0.760 | 0.263 | 1 | 0.782 |
PRKD1 |
0.759 | 0.272 | -3 | 0.780 |
NDR2 |
0.752 | 0.206 | -3 | 0.796 |
KIS |
0.752 | 0.190 | 1 | 0.755 |
CDC7 |
0.752 | 0.129 | 1 | 0.824 |
COT |
0.751 | 0.094 | 2 | 0.704 |
PIM3 |
0.750 | 0.174 | -3 | 0.785 |
RSK2 |
0.747 | 0.153 | -3 | 0.723 |
GRK1 |
0.747 | 0.160 | -2 | 0.742 |
HIPK2 |
0.747 | 0.208 | 1 | 0.703 |
ERK5 |
0.746 | 0.151 | 1 | 0.825 |
MAPKAPK2 |
0.745 | 0.143 | -3 | 0.698 |
CLK2 |
0.745 | 0.167 | -3 | 0.698 |
PRKD2 |
0.745 | 0.142 | -3 | 0.729 |
MOS |
0.744 | 0.136 | 1 | 0.812 |
SRPK1 |
0.744 | 0.140 | -3 | 0.708 |
DYRK2 |
0.743 | 0.176 | 1 | 0.763 |
CDK18 |
0.743 | 0.183 | 1 | 0.717 |
P90RSK |
0.742 | 0.169 | -3 | 0.722 |
CDK19 |
0.742 | 0.164 | 1 | 0.722 |
CDK7 |
0.741 | 0.146 | 1 | 0.761 |
CDK8 |
0.740 | 0.146 | 1 | 0.751 |
SKMLCK |
0.740 | 0.138 | -2 | 0.732 |
P38B |
0.739 | 0.191 | 1 | 0.744 |
NLK |
0.738 | 0.116 | 1 | 0.836 |
BMPR1B |
0.738 | 0.125 | 1 | 0.854 |
JNK2 |
0.738 | 0.172 | 1 | 0.727 |
CDK1 |
0.738 | 0.162 | 1 | 0.766 |
LATS2 |
0.737 | 0.134 | -5 | 0.526 |
MTOR |
0.737 | 0.032 | 1 | 0.758 |
ICK |
0.736 | 0.148 | -3 | 0.777 |
P38D |
0.736 | 0.209 | 1 | 0.665 |
RSK4 |
0.735 | 0.153 | -3 | 0.705 |
PIM1 |
0.735 | 0.124 | -3 | 0.730 |
CDKL5 |
0.735 | 0.091 | -3 | 0.733 |
HIPK1 |
0.735 | 0.186 | 1 | 0.771 |
JNK3 |
0.734 | 0.163 | 1 | 0.749 |
PRPK |
0.734 | 0.017 | -1 | 0.287 |
IKKB |
0.733 | -0.004 | -2 | 0.655 |
CDKL1 |
0.733 | 0.064 | -3 | 0.735 |
IKKA |
0.733 | 0.086 | -2 | 0.661 |
ATR |
0.732 | 0.068 | 1 | 0.758 |
CAMK2A |
0.732 | 0.127 | 2 | 0.683 |
DYRK4 |
0.732 | 0.164 | 1 | 0.724 |
ERK1 |
0.732 | 0.152 | 1 | 0.727 |
MAPKAPK3 |
0.731 | 0.083 | -3 | 0.731 |
AURC |
0.731 | 0.053 | -2 | 0.531 |
MAK |
0.730 | 0.210 | -2 | 0.754 |
LATS1 |
0.730 | 0.251 | -3 | 0.815 |
CHAK2 |
0.730 | 0.059 | -1 | 0.266 |
GRK7 |
0.730 | 0.102 | 1 | 0.774 |
CDK17 |
0.729 | 0.156 | 1 | 0.688 |
CAMK2D |
0.729 | 0.081 | -3 | 0.766 |
P38G |
0.728 | 0.147 | 1 | 0.688 |
P38A |
0.728 | 0.157 | 1 | 0.779 |
CDK3 |
0.727 | 0.154 | 1 | 0.703 |
NDR1 |
0.727 | 0.050 | -3 | 0.773 |
GRK5 |
0.727 | 0.003 | -3 | 0.751 |
PASK |
0.727 | 0.257 | -3 | 0.809 |
CAMK1B |
0.726 | 0.010 | -3 | 0.771 |
RSK3 |
0.726 | 0.059 | -3 | 0.708 |
CAMK2B |
0.725 | 0.073 | 2 | 0.662 |
SRPK2 |
0.725 | 0.078 | -3 | 0.629 |
CDK5 |
0.725 | 0.145 | 1 | 0.772 |
CDK13 |
0.725 | 0.106 | 1 | 0.738 |
BMPR2 |
0.725 | -0.102 | -2 | 0.785 |
TGFBR2 |
0.724 | 0.018 | -2 | 0.712 |
RAF1 |
0.724 | -0.069 | 1 | 0.744 |
DYRK1A |
0.723 | 0.155 | 1 | 0.780 |
TGFBR1 |
0.723 | 0.053 | -2 | 0.752 |
CLK4 |
0.723 | 0.068 | -3 | 0.705 |
PKACB |
0.722 | 0.062 | -2 | 0.535 |
NUAK2 |
0.722 | 0.029 | -3 | 0.776 |
SRPK3 |
0.721 | 0.072 | -3 | 0.666 |
TBK1 |
0.721 | -0.024 | 1 | 0.619 |
PRKX |
0.721 | 0.069 | -3 | 0.663 |
CDK16 |
0.721 | 0.150 | 1 | 0.696 |
DAPK2 |
0.721 | 0.046 | -3 | 0.784 |
PDHK4 |
0.721 | -0.169 | 1 | 0.773 |
CLK1 |
0.720 | 0.068 | -3 | 0.685 |
DSTYK |
0.720 | -0.129 | 2 | 0.732 |
IKKE |
0.719 | -0.042 | 1 | 0.614 |
CDK12 |
0.719 | 0.107 | 1 | 0.718 |
CDK10 |
0.719 | 0.133 | 1 | 0.731 |
CAMLCK |
0.718 | 0.003 | -2 | 0.718 |
ALK4 |
0.718 | 0.038 | -2 | 0.766 |
CAMK2G |
0.718 | -0.091 | 2 | 0.664 |
GRK6 |
0.718 | -0.022 | 1 | 0.812 |
CDK14 |
0.718 | 0.146 | 1 | 0.741 |
ACVR2B |
0.717 | 0.038 | -2 | 0.720 |
TSSK1 |
0.717 | 0.102 | -3 | 0.803 |
HIPK3 |
0.717 | 0.138 | 1 | 0.746 |
MSK1 |
0.717 | 0.053 | -3 | 0.702 |
NIK |
0.717 | -0.023 | -3 | 0.785 |
GCN2 |
0.717 | -0.152 | 2 | 0.641 |
P70S6KB |
0.717 | -0.001 | -3 | 0.725 |
JNK1 |
0.717 | 0.140 | 1 | 0.731 |
DYRK1B |
0.717 | 0.134 | 1 | 0.738 |
MLK2 |
0.716 | 0.019 | 2 | 0.658 |
PKN3 |
0.716 | 0.020 | -3 | 0.749 |
PKACG |
0.715 | 0.002 | -2 | 0.602 |
TSSK2 |
0.715 | 0.078 | -5 | 0.622 |
AMPKA1 |
0.715 | 0.025 | -3 | 0.785 |
NEK6 |
0.715 | -0.087 | -2 | 0.729 |
CDK9 |
0.714 | 0.090 | 1 | 0.740 |
ERK2 |
0.714 | 0.094 | 1 | 0.765 |
GRK2 |
0.714 | 0.052 | -2 | 0.653 |
ACVR2A |
0.714 | 0.019 | -2 | 0.709 |
AMPKA2 |
0.713 | 0.047 | -3 | 0.761 |
MASTL |
0.713 | 0.002 | -2 | 0.707 |
MPSK1 |
0.713 | 0.181 | 1 | 0.677 |
PKCD |
0.713 | 0.021 | 2 | 0.608 |
DLK |
0.713 | -0.050 | 1 | 0.784 |
MARK4 |
0.713 | -0.004 | 4 | 0.777 |
RIPK3 |
0.713 | -0.083 | 3 | 0.694 |
PRKD3 |
0.713 | 0.034 | -3 | 0.692 |
MLK3 |
0.713 | 0.005 | 2 | 0.575 |
MLK1 |
0.713 | -0.098 | 2 | 0.636 |
GRK4 |
0.713 | -0.081 | -2 | 0.744 |
HUNK |
0.712 | -0.069 | 2 | 0.652 |
GSK3A |
0.712 | 0.100 | 4 | 0.507 |
PKN2 |
0.712 | -0.022 | -3 | 0.764 |
PDHK1 |
0.712 | -0.170 | 1 | 0.727 |
PRP4 |
0.711 | 0.077 | -3 | 0.708 |
MST4 |
0.711 | -0.076 | 2 | 0.720 |
ALK2 |
0.711 | 0.004 | -2 | 0.757 |
BMPR1A |
0.711 | 0.048 | 1 | 0.819 |
PIM2 |
0.711 | 0.076 | -3 | 0.687 |
MSK2 |
0.711 | 0.004 | -3 | 0.699 |
WNK1 |
0.710 | -0.113 | -2 | 0.763 |
PAK1 |
0.709 | -0.033 | -2 | 0.661 |
MNK1 |
0.709 | 0.059 | -2 | 0.653 |
SMG1 |
0.709 | -0.034 | 1 | 0.699 |
MOK |
0.709 | 0.147 | 1 | 0.768 |
ULK2 |
0.708 | -0.184 | 2 | 0.597 |
DYRK3 |
0.708 | 0.085 | 1 | 0.755 |
ATM |
0.707 | -0.066 | 1 | 0.694 |
AKT2 |
0.706 | 0.028 | -3 | 0.646 |
PKG2 |
0.706 | 0.020 | -2 | 0.542 |
CHK1 |
0.706 | 0.068 | -3 | 0.757 |
PKCA |
0.706 | 0.018 | 2 | 0.560 |
PKCB |
0.705 | -0.006 | 2 | 0.563 |
CK1E |
0.705 | 0.017 | -3 | 0.515 |
NEK7 |
0.705 | -0.203 | -3 | 0.760 |
BCKDK |
0.705 | -0.167 | -1 | 0.202 |
CDK2 |
0.705 | 0.036 | 1 | 0.819 |
QSK |
0.704 | 0.025 | 4 | 0.747 |
BUB1 |
0.704 | 0.164 | -5 | 0.607 |
TLK2 |
0.704 | -0.041 | 1 | 0.683 |
FAM20C |
0.704 | -0.048 | 2 | 0.505 |
GRK3 |
0.704 | 0.039 | -2 | 0.620 |
ERK7 |
0.704 | 0.044 | 2 | 0.439 |
DRAK1 |
0.703 | 0.006 | 1 | 0.826 |
AURB |
0.703 | -0.012 | -2 | 0.525 |
BRSK1 |
0.703 | 0.007 | -3 | 0.728 |
CK1D |
0.703 | 0.039 | -3 | 0.474 |
TTBK2 |
0.703 | -0.114 | 2 | 0.536 |
DNAPK |
0.703 | -0.017 | 1 | 0.607 |
PAK3 |
0.702 | -0.066 | -2 | 0.650 |
YSK4 |
0.702 | -0.043 | 1 | 0.691 |
VRK2 |
0.702 | -0.006 | 1 | 0.783 |
DCAMKL1 |
0.702 | 0.032 | -3 | 0.736 |
GSK3B |
0.702 | 0.048 | 4 | 0.499 |
MYLK4 |
0.702 | -0.028 | -2 | 0.632 |
PKCG |
0.701 | -0.023 | 2 | 0.563 |
PHKG1 |
0.701 | -0.027 | -3 | 0.763 |
MNK2 |
0.701 | -0.060 | -2 | 0.643 |
NEK9 |
0.700 | -0.174 | 2 | 0.659 |
CAMK4 |
0.700 | -0.062 | -3 | 0.741 |
PKACA |
0.700 | 0.020 | -2 | 0.494 |
SGK3 |
0.700 | -0.002 | -3 | 0.720 |
MLK4 |
0.699 | -0.070 | 2 | 0.546 |
RIPK1 |
0.699 | -0.186 | 1 | 0.703 |
PKR |
0.699 | -0.089 | 1 | 0.717 |
MEK1 |
0.699 | -0.111 | 2 | 0.684 |
NUAK1 |
0.699 | -0.003 | -3 | 0.718 |
PLK1 |
0.699 | -0.104 | -2 | 0.683 |
MELK |
0.698 | -0.034 | -3 | 0.738 |
AURA |
0.698 | -0.032 | -2 | 0.505 |
IRE1 |
0.697 | -0.098 | 1 | 0.669 |
CK2A2 |
0.696 | 0.018 | 1 | 0.774 |
NIM1 |
0.696 | -0.110 | 3 | 0.725 |
PAK6 |
0.696 | -0.054 | -2 | 0.569 |
CDK6 |
0.696 | 0.105 | 1 | 0.712 |
MARK3 |
0.696 | 0.000 | 4 | 0.703 |
CHAK1 |
0.696 | -0.067 | 2 | 0.643 |
MST3 |
0.695 | -0.018 | 2 | 0.697 |
ULK1 |
0.695 | -0.212 | -3 | 0.701 |
LKB1 |
0.695 | 0.060 | -3 | 0.754 |
PKCZ |
0.695 | -0.045 | 2 | 0.605 |
BRSK2 |
0.695 | -0.021 | -3 | 0.742 |
PLK3 |
0.695 | -0.070 | 2 | 0.630 |
PAK2 |
0.694 | -0.074 | -2 | 0.641 |
ANKRD3 |
0.694 | -0.218 | 1 | 0.745 |
MAPKAPK5 |
0.694 | -0.071 | -3 | 0.658 |
SIK |
0.694 | -0.023 | -3 | 0.697 |
WNK3 |
0.693 | -0.271 | 1 | 0.694 |
CDK4 |
0.693 | 0.093 | 1 | 0.708 |
P70S6K |
0.691 | -0.004 | -3 | 0.647 |
CK1A2 |
0.691 | 0.003 | -3 | 0.473 |
SBK |
0.691 | 0.072 | -3 | 0.544 |
CK1G1 |
0.691 | -0.006 | -3 | 0.503 |
IRE2 |
0.690 | -0.037 | 2 | 0.534 |
SSTK |
0.690 | 0.045 | 4 | 0.729 |
TAO3 |
0.690 | -0.046 | 1 | 0.729 |
QIK |
0.690 | -0.108 | -3 | 0.758 |
PKCH |
0.690 | -0.060 | 2 | 0.532 |
GAK |
0.689 | 0.013 | 1 | 0.763 |
CK2A1 |
0.689 | 0.017 | 1 | 0.772 |
AKT1 |
0.689 | 0.001 | -3 | 0.671 |
CAMK1D |
0.688 | 0.021 | -3 | 0.635 |
MARK2 |
0.688 | -0.040 | 4 | 0.672 |
GCK |
0.688 | 0.032 | 1 | 0.733 |
PERK |
0.686 | -0.137 | -2 | 0.747 |
CAMK1G |
0.686 | -0.037 | -3 | 0.685 |
DCAMKL2 |
0.686 | -0.037 | -3 | 0.743 |
MEK5 |
0.686 | -0.165 | 2 | 0.655 |
NEK2 |
0.686 | -0.169 | 2 | 0.649 |
DAPK3 |
0.685 | 0.004 | -3 | 0.741 |
AKT3 |
0.685 | 0.023 | -3 | 0.608 |
NEK5 |
0.685 | -0.104 | 1 | 0.706 |
BRAF |
0.683 | -0.147 | -4 | 0.788 |
ZAK |
0.683 | -0.135 | 1 | 0.697 |
SMMLCK |
0.683 | -0.052 | -3 | 0.736 |
PINK1 |
0.682 | -0.132 | 1 | 0.756 |
SGK1 |
0.682 | 0.021 | -3 | 0.585 |
MARK1 |
0.681 | -0.059 | 4 | 0.716 |
CAMKK2 |
0.681 | -0.068 | -2 | 0.685 |
MEKK1 |
0.681 | -0.122 | 1 | 0.690 |
PLK2 |
0.681 | -0.016 | -3 | 0.638 |
MEKK3 |
0.681 | -0.196 | 1 | 0.736 |
MEKK2 |
0.680 | -0.151 | 2 | 0.619 |
DAPK1 |
0.680 | -0.003 | -3 | 0.723 |
PKCE |
0.680 | -0.017 | 2 | 0.551 |
TLK1 |
0.679 | -0.150 | -2 | 0.740 |
MAP3K15 |
0.679 | -0.002 | 1 | 0.679 |
CAMKK1 |
0.679 | -0.128 | -2 | 0.687 |
CK1A |
0.679 | 0.039 | -3 | 0.394 |
CHK2 |
0.679 | 0.006 | -3 | 0.599 |
PDK1 |
0.678 | -0.044 | 1 | 0.683 |
HPK1 |
0.678 | -0.044 | 1 | 0.714 |
PKCT |
0.678 | -0.066 | 2 | 0.541 |
ROCK2 |
0.678 | 0.026 | -3 | 0.736 |
PLK4 |
0.678 | -0.159 | 2 | 0.453 |
IRAK4 |
0.677 | -0.120 | 1 | 0.658 |
SNRK |
0.676 | -0.157 | 2 | 0.509 |
NEK11 |
0.676 | -0.142 | 1 | 0.710 |
KHS1 |
0.676 | 0.037 | 1 | 0.667 |
PAK5 |
0.676 | -0.080 | -2 | 0.512 |
PBK |
0.676 | 0.013 | 1 | 0.660 |
MEKK6 |
0.676 | -0.067 | 1 | 0.711 |
PAK4 |
0.676 | -0.068 | -2 | 0.524 |
TNIK |
0.675 | -0.027 | 3 | 0.819 |
TTBK1 |
0.675 | -0.142 | 2 | 0.464 |
TAK1 |
0.674 | -0.123 | 1 | 0.719 |
HGK |
0.674 | -0.049 | 3 | 0.819 |
HRI |
0.674 | -0.229 | -2 | 0.736 |
CRIK |
0.674 | 0.043 | -3 | 0.676 |
TAO2 |
0.673 | -0.116 | 2 | 0.675 |
MST2 |
0.673 | -0.083 | 1 | 0.720 |
CAMK1A |
0.673 | 0.014 | -3 | 0.613 |
EEF2K |
0.673 | -0.049 | 3 | 0.768 |
KHS2 |
0.672 | -0.010 | 1 | 0.697 |
MRCKA |
0.672 | -0.007 | -3 | 0.692 |
WNK4 |
0.672 | -0.201 | -2 | 0.750 |
PKCI |
0.672 | -0.088 | 2 | 0.566 |
SLK |
0.672 | -0.057 | -2 | 0.596 |
DMPK1 |
0.671 | 0.044 | -3 | 0.702 |
LRRK2 |
0.671 | -0.090 | 2 | 0.677 |
MRCKB |
0.670 | -0.030 | -3 | 0.677 |
PDHK3_TYR |
0.670 | 0.286 | 4 | 0.854 |
LOK |
0.670 | -0.074 | -2 | 0.635 |
NEK8 |
0.670 | -0.181 | 2 | 0.637 |
MINK |
0.670 | -0.085 | 1 | 0.681 |
NEK1 |
0.669 | -0.073 | 1 | 0.674 |
PKN1 |
0.669 | -0.032 | -3 | 0.669 |
NEK4 |
0.669 | -0.135 | 1 | 0.660 |
PHKG2 |
0.668 | -0.086 | -3 | 0.718 |
VRK1 |
0.667 | -0.110 | 2 | 0.633 |
YANK3 |
0.667 | -0.007 | 2 | 0.338 |
MST1 |
0.665 | -0.064 | 1 | 0.692 |
HASPIN |
0.664 | -0.048 | -1 | 0.192 |
PDHK4_TYR |
0.663 | 0.170 | 2 | 0.752 |
OSR1 |
0.661 | -0.061 | 2 | 0.648 |
IRAK1 |
0.661 | -0.259 | -1 | 0.197 |
STK33 |
0.660 | -0.141 | 2 | 0.485 |
AAK1 |
0.660 | 0.078 | 1 | 0.539 |
BIKE |
0.658 | -0.008 | 1 | 0.630 |
MAP2K4_TYR |
0.658 | 0.091 | -1 | 0.273 |
TESK1_TYR |
0.657 | 0.134 | 3 | 0.840 |
MAP2K6_TYR |
0.657 | 0.059 | -1 | 0.267 |
PKG1 |
0.656 | -0.060 | -2 | 0.468 |
YSK1 |
0.656 | -0.120 | 2 | 0.643 |
ASK1 |
0.656 | -0.032 | 1 | 0.669 |
ROCK1 |
0.655 | -0.037 | -3 | 0.690 |
MEK2 |
0.655 | -0.196 | 2 | 0.638 |
TXK |
0.654 | 0.072 | 1 | 0.852 |
TTK |
0.654 | -0.047 | -2 | 0.715 |
LIMK2_TYR |
0.653 | 0.131 | -3 | 0.803 |
PDHK1_TYR |
0.652 | 0.008 | -1 | 0.264 |
PKMYT1_TYR |
0.650 | 0.076 | 3 | 0.812 |
ALPHAK3 |
0.650 | -0.080 | -1 | 0.210 |
BMPR2_TYR |
0.649 | -0.048 | -1 | 0.222 |
MYO3B |
0.648 | -0.073 | 2 | 0.665 |
FGR |
0.647 | 0.143 | 1 | 0.789 |
RIPK2 |
0.646 | -0.239 | 1 | 0.640 |
MAP2K7_TYR |
0.645 | -0.085 | 2 | 0.701 |
NEK3 |
0.644 | -0.198 | 1 | 0.636 |
ABL2 |
0.644 | 0.005 | -1 | 0.229 |
EPHB4 |
0.644 | -0.028 | -1 | 0.224 |
SRMS |
0.642 | -0.021 | 1 | 0.813 |
ABL1 |
0.641 | -0.007 | -1 | 0.232 |
TNK2 |
0.641 | 0.022 | 3 | 0.731 |
TAO1 |
0.640 | -0.125 | 1 | 0.624 |
EPHA6 |
0.640 | -0.071 | -1 | 0.213 |
YES1 |
0.640 | 0.022 | -1 | 0.326 |
ITK |
0.639 | -0.026 | -1 | 0.230 |
PINK1_TYR |
0.639 | -0.146 | 1 | 0.781 |
BMX |
0.638 | -0.024 | -1 | 0.208 |
RET |
0.638 | -0.068 | 1 | 0.709 |
MYO3A |
0.638 | -0.122 | 1 | 0.655 |
CSF1R |
0.637 | -0.001 | 3 | 0.751 |
FER |
0.637 | -0.041 | 1 | 0.808 |
TYRO3 |
0.636 | -0.056 | 3 | 0.747 |
EPHA4 |
0.636 | -0.039 | 2 | 0.659 |
ROS1 |
0.635 | 0.035 | 3 | 0.711 |
LCK |
0.635 | -0.015 | -1 | 0.262 |
FYN |
0.635 | 0.002 | -1 | 0.280 |
PTK2B |
0.635 | 0.006 | -1 | 0.243 |
STLK3 |
0.634 | -0.148 | 1 | 0.663 |
YANK2 |
0.634 | -0.029 | 2 | 0.344 |
MERTK |
0.634 | -0.040 | 3 | 0.739 |
CK1G3 |
0.634 | -0.040 | -3 | 0.355 |
LIMK1_TYR |
0.634 | -0.077 | 2 | 0.676 |
JAK2 |
0.633 | -0.021 | 1 | 0.692 |
HCK |
0.633 | -0.063 | -1 | 0.261 |
BLK |
0.632 | -0.023 | -1 | 0.253 |
EPHB1 |
0.632 | -0.081 | 1 | 0.797 |
MST1R |
0.631 | -0.108 | 3 | 0.764 |
KIT |
0.631 | -0.060 | 3 | 0.752 |
JAK1 |
0.630 | 0.056 | 1 | 0.637 |
TYK2 |
0.630 | -0.077 | 1 | 0.686 |
INSRR |
0.630 | -0.058 | 3 | 0.690 |
EPHB3 |
0.630 | -0.086 | -1 | 0.215 |
TEC |
0.629 | -0.079 | -1 | 0.220 |
EPHB2 |
0.629 | -0.081 | -1 | 0.206 |
DDR1 |
0.629 | -0.099 | 4 | 0.752 |
MET |
0.629 | -0.057 | 3 | 0.749 |
PTK2 |
0.629 | -0.009 | -1 | 0.182 |
JAK3 |
0.628 | -0.108 | 1 | 0.716 |
AXL |
0.628 | -0.083 | 3 | 0.730 |
NEK10_TYR |
0.627 | -0.045 | 1 | 0.611 |
CK1G2 |
0.625 | -0.032 | -3 | 0.432 |
FGFR2 |
0.625 | -0.113 | 3 | 0.749 |
SYK |
0.625 | -0.023 | -1 | 0.190 |
TNK1 |
0.624 | -0.014 | 3 | 0.736 |
NTRK3 |
0.623 | -0.042 | -1 | 0.251 |
SRC |
0.623 | -0.028 | -1 | 0.291 |
BTK |
0.622 | -0.139 | -1 | 0.239 |
EPHA7 |
0.622 | -0.083 | 2 | 0.640 |
TNNI3K_TYR |
0.622 | -0.015 | 1 | 0.685 |
PTK6 |
0.622 | -0.114 | -1 | 0.249 |
EPHA3 |
0.621 | -0.101 | 2 | 0.619 |
KDR |
0.621 | -0.099 | 3 | 0.710 |
DDR2 |
0.620 | 0.040 | 3 | 0.683 |
MATK |
0.619 | -0.083 | -1 | 0.198 |
LYN |
0.619 | -0.074 | 3 | 0.669 |
ALK |
0.619 | -0.063 | 3 | 0.661 |
PDGFRB |
0.619 | -0.141 | 3 | 0.751 |
FGFR1 |
0.619 | -0.109 | 3 | 0.715 |
FGFR3 |
0.618 | -0.107 | 3 | 0.717 |
NTRK1 |
0.618 | -0.110 | -1 | 0.251 |
TEK |
0.618 | -0.110 | 3 | 0.681 |
WEE1_TYR |
0.618 | -0.106 | -1 | 0.221 |
LTK |
0.618 | -0.098 | 3 | 0.688 |
FLT1 |
0.617 | -0.130 | -1 | 0.198 |
EPHA5 |
0.616 | -0.097 | 2 | 0.632 |
EPHA8 |
0.616 | -0.085 | -1 | 0.197 |
FLT3 |
0.616 | -0.153 | 3 | 0.750 |
EGFR |
0.615 | -0.073 | 1 | 0.644 |
FRK |
0.615 | -0.110 | -1 | 0.230 |
FGFR4 |
0.615 | -0.077 | -1 | 0.215 |
EPHA1 |
0.614 | -0.116 | 3 | 0.724 |
ZAP70 |
0.614 | -0.019 | -1 | 0.160 |
CSK |
0.614 | -0.107 | 2 | 0.638 |
INSR |
0.613 | -0.095 | 3 | 0.669 |
ERBB2 |
0.613 | -0.137 | 1 | 0.706 |
PDGFRA |
0.611 | -0.146 | 3 | 0.749 |
NTRK2 |
0.609 | -0.155 | 3 | 0.700 |
EPHA2 |
0.609 | -0.095 | -1 | 0.171 |
ERBB4 |
0.604 | -0.068 | 1 | 0.686 |
FLT4 |
0.604 | -0.190 | 3 | 0.705 |
FES |
0.603 | -0.075 | -1 | 0.216 |
IGF1R |
0.601 | -0.090 | 3 | 0.605 |
MUSK |
0.596 | -0.125 | 1 | 0.627 |