Motif 507 (n=147)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A7MCY6 | TBKBP1 | S388 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| A8MYZ6 | FOXO6 | S210 | ochoa | Forkhead box protein O6 | Transcriptional activator. {ECO:0000250}. |
| O00204 | SULT2B1 | S347 | ochoa | Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}.; FUNCTION: [Isoform 2]: Sulfonates pregnenolone but not cholesterol. {ECO:0000269|PubMed:12145317}. |
| O00512 | BCL9 | S294 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14686 | KMT2D | S4617 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15085 | ARHGEF11 | S146 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15417 | TNRC18 | S1028 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15530 | PDPK1 | S64 | ochoa|psp | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| O43566 | RGS14 | S40 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60784 | TOM1 | S462 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75081 | CBFA2T3 | Y327 | ochoa | Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665). {ECO:0000250|UniProtKB:O54972, ECO:0000269|PubMed:12183414, ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:16966434, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23840896, ECO:0000269|PubMed:25974097, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.; FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486). {ECO:0000269|PubMed:11823486}. |
| O75533 | SF3B1 | S344 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75952 | CABYR | S141 | ochoa | Calcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Cancer/testis antigen 88) (CT88) (Fibrousheathin II) (Fibrousheathin-2) (FSP-2) (Testis-specific calcium-binding protein CBP86) | May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. |
| O75962 | TRIO | S1740 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O75995 | SASH3 | S108 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O75995 | SASH3 | S153 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O94804 | STK10 | S387 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94868 | FCHSD2 | Y659 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94887 | FARP2 | S457 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95429 | BAG4 | S281 | ochoa | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| O95677 | EYA4 | S134 | ochoa | Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}. |
| O95785 | WIZ | S1129 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P10398 | ARAF | S172 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P11137 | MAP2 | S1611 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P17542 | TAL1 | T90 | psp | T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5) | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}. |
| P18858 | LIG1 | S104 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P20810 | CAST | S544 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P23396 | RPS3 | S224 | ochoa|psp | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| P23588 | EIF4B | S71 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P24928 | POLR2A | S1621 | psp | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P24928 | POLR2A | S1845 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P27987 | ITPKB | S29 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P29590 | PML | T513 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P30260 | CDC27 | S364 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P38159 | RBMX | S91 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P48634 | PRRC2A | S114 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | T1133 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48681 | NES | S346 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49815 | TSC2 | T659 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P54259 | ATN1 | Y734 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P56693 | SOX10 | S232 | psp | Transcription factor SOX-10 | Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}. |
| P78344 | EIF4G2 | S500 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P78524 | DENND2B | S28 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78524 | DENND2B | S413 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q03111 | MLLT1 | S265 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q04206 | RELA | S311 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q08378 | GOLGA3 | S21 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q09472 | EP300 | S2320 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q12789 | GTF3C1 | S1840 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q13424 | SNTA1 | S184 | ochoa | Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}. |
| Q13586 | STIM1 | S616 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q13671 | RIN1 | T253 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14160 | SCRIB | S1330 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14185 | DOCK1 | S1758 | ochoa | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}. |
| Q15648 | MED1 | S1202 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15742 | NAB2 | S157 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q1W6H9 | FAM110C | S174 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q2M1Z3 | ARHGAP31 | S1346 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2NKX8 | ERCC6L | S739 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q3KQU3 | MAP7D1 | S88 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3KQU3 | MAP7D1 | S471 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4KMQ1 | TPRN | S269 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q53ET0 | CRTC2 | S178 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5JRA6 | MIA3 | S1673 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5PRF9 | SAMD4B | S238 | ochoa|psp | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5VT06 | CEP350 | S707 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VZK9 | CARMIL1 | S1249 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q68DK7 | MSL1 | S392 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q68EM7 | ARHGAP17 | Y701 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6A1A2 | PDPK2P | S37 | ochoa | Putative 3-phosphoinositide-dependent protein kinase 2 (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase 2 pseudogene) | Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). {ECO:0000250}. |
| Q6IQ23 | PLEKHA7 | S563 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6P1N0 | CC2D1A | S203 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6PJG9 | LRFN4 | S565 | ochoa | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}. |
| Q6UXY1 | BAIAP2L2 | S457 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6VMQ6 | ATF7IP | S123 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6W2J9 | BCOR | S1405 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZNC4 | ZNF704 | S259 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q70E73 | RAPH1 | S1014 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q76L83 | ASXL2 | S1290 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q76N32 | CEP68 | S237 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7KZI7 | MARK2 | S551 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L2J0 | MEPCE | S340 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z2Z1 | TICRR | S1428 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q86TJ2 | TADA2B | S139 | ochoa | Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) | Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}. |
| Q86TV6 | TTC7B | S673 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
| Q86UU1 | PHLDB1 | T376 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UY5 | FAM83A | S348 | ochoa | Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) | Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}. |
| Q86UY5 | FAM83A | S352 | ochoa | Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) | Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}. |
| Q86VM9 | ZC3H18 | S790 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86X29 | LSR | S332 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86XL3 | ANKLE2 | S259 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YW5 | TREML1 | S247 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IVT2 | MISP | S395 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWY9 | CDAN1 | S265 | ochoa | Codanin-1 | May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}. |
| Q8IZ21 | PHACTR4 | S283 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N1I0 | DOCK4 | S1750 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N4L2 | PIP4P2 | Y28 | ochoa | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). {ECO:0000250|UniProtKB:Q9CZX7, ECO:0000269|PubMed:16365287}. |
| Q8N684 | CPSF7 | S48 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NDV7 | TNRC6A | S1580 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NI27 | THOC2 | S1388 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TCZ2 | CD99L2 | S244 | ochoa | CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) | Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}. |
| Q8TD08 | MAPK15 | S379 | psp | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q8WUM4 | PDCD6IP | S729 | ochoa | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q92793 | CREBBP | S2356 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92797 | SYMPK | S1169 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q96AP7 | ESAM | S366 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
| Q96D71 | REPS1 | S540 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96HA1 | POM121 | S174 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96MY1 | NOL4L | S386 | ochoa | Nucleolar protein 4-like | None |
| Q96N21 | TEPSIN | S413 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96QT6 | PHF12 | S657 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96ST3 | SIN3A | Y272 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q9BRD0 | BUD13 | S402 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRK4 | LZTS2 | S306 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BTA9 | WAC | S261 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BTC0 | DIDO1 | T1255 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUL5 | PHF23 | S153 | ochoa | PHD finger protein 23 (PDH-containing protein JUNE-1) | Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}. |
| Q9BX66 | SORBS1 | S235 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9C0E8 | LNPK | S177 | ochoa | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}. |
| Q9C0K0 | BCL11B | S256 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H201 | EPN3 | S444 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H2G4 | TSPYL2 | S18 | ochoa | Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79) | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}. |
| Q9H330 | TMEM245 | S325 | ochoa | Transmembrane protein 245 (Protein CG-2) | None |
| Q9H792 | PEAK1 | S856 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7D0 | DOCK5 | S1780 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9HA65 | TBC1D17 | S608 | ochoa | TBC1 domain family member 17 | Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}. |
| Q9NQS7 | INCENP | S476 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NR12 | PDLIM7 | S203 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NYV6 | RRN3 | S635 | ochoa|psp | RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) | Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}. |
| Q9P0U4 | CXXC1 | S263 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P242 | NYAP2 | S464 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P246 | STIM2 | S518 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9UBP9 | GULP1 | S206 | ochoa | PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) | May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}. |
| Q9UET6 | FTSJ1 | S258 | ochoa | tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) | Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). Requisite for faithful cytoplasmic translation (PubMed:32393790). Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Promotes translation efficiency of the UUU codon (PubMed:32558197). Plays a role in neurogenesis (PubMed:36720500). Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis (PubMed:33771871, PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:36720500). May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). {ECO:0000269|PubMed:25404562, ECO:0000269|PubMed:26310293, ECO:0000269|PubMed:32198346, ECO:0000269|PubMed:32393790, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36720500}. |
| Q9UKS6 | PACSIN3 | S327 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9ULJ3 | ZBTB21 | T979 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULM3 | YEATS2 | S463 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9ULV3 | CIZ1 | S573 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMN6 | KMT2B | S500 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMN6 | KMT2B | T2283 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPT8 | ZC3H4 | S165 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQ35 | SRRM2 | S353 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S890 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1616 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2J4 | AMOTL2 | S179 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y4U1 | MMACHC | S240 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
| Q9Y520 | PRRC2C | S2680 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.000114 | 3.945 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.000104 | 3.985 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.000153 | 3.814 |
| R-HSA-4839726 | Chromatin organization | 0.000342 | 3.466 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.000459 | 3.338 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.000515 | 3.289 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000756 | 3.121 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000821 | 3.086 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.000945 | 3.025 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.001146 | 2.941 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.001338 | 2.873 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.001636 | 2.786 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.001607 | 2.794 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.002213 | 2.655 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.002213 | 2.655 |
| R-HSA-162582 | Signal Transduction | 0.002036 | 2.691 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.002840 | 2.547 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.003005 | 2.522 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.003304 | 2.481 |
| R-HSA-3214847 | HATs acetylate histones | 0.004709 | 2.327 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.005472 | 2.262 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005326 | 2.274 |
| R-HSA-9707616 | Heme signaling | 0.005136 | 2.289 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.006299 | 2.201 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.006299 | 2.201 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.008265 | 2.083 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.009656 | 2.015 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.009443 | 2.025 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.010917 | 1.962 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.010917 | 1.962 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.010917 | 1.962 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.012246 | 1.912 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.011920 | 1.924 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.011920 | 1.924 |
| R-HSA-165159 | MTOR signalling | 0.013285 | 1.877 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.015105 | 1.821 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.015105 | 1.821 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.015105 | 1.821 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.015105 | 1.821 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.014473 | 1.839 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 0.028828 | 1.540 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 0.028828 | 1.540 |
| R-HSA-3359473 | Defective MMADHC causes MMAHCD | 0.028828 | 1.540 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.018221 | 1.739 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.021583 | 1.666 |
| R-HSA-72187 | mRNA 3'-end processing | 0.021406 | 1.669 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.022338 | 1.651 |
| R-HSA-72649 | Translation initiation complex formation | 0.023292 | 1.633 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.025265 | 1.597 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.025265 | 1.597 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.027325 | 1.563 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.027064 | 1.568 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.027565 | 1.560 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.027565 | 1.560 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.021319 | 1.671 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.017635 | 1.754 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.017897 | 1.747 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.018221 | 1.739 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.027064 | 1.568 |
| R-HSA-8953854 | Metabolism of RNA | 0.020675 | 1.685 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.018221 | 1.739 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.016631 | 1.779 |
| R-HSA-74160 | Gene expression (Transcription) | 0.017409 | 1.759 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.019871 | 1.702 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.023293 | 1.633 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.019871 | 1.702 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.021583 | 1.666 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.025265 | 1.597 |
| R-HSA-5358508 | Mismatch Repair | 0.021583 | 1.666 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.027064 | 1.568 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.027064 | 1.568 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.025115 | 1.600 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.023293 | 1.633 |
| R-HSA-73887 | Death Receptor Signaling | 0.027406 | 1.562 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.017690 | 1.752 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.029003 | 1.538 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.029086 | 1.536 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.030579 | 1.515 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.030996 | 1.509 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.031707 | 1.499 |
| R-HSA-429947 | Deadenylation of mRNA | 0.035138 | 1.454 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.035138 | 1.454 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.036434 | 1.438 |
| R-HSA-195721 | Signaling by WNT | 0.037229 | 1.429 |
| R-HSA-9839394 | TGFBR3 expression | 0.037285 | 1.428 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.047587 | 1.323 |
| R-HSA-3359474 | Defective MMACHC causes MAHCC | 0.047587 | 1.323 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.047587 | 1.323 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.047587 | 1.323 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.041726 | 1.380 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.048309 | 1.316 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.044163 | 1.355 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.049080 | 1.309 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.049080 | 1.309 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.049080 | 1.309 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.044008 | 1.356 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.039482 | 1.404 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.042822 | 1.368 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.047587 | 1.323 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.039482 | 1.404 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.042822 | 1.368 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.044163 | 1.355 |
| R-HSA-8939211 | ESR-mediated signaling | 0.041057 | 1.387 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.042822 | 1.368 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.046000 | 1.337 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.051161 | 1.291 |
| R-HSA-2262752 | Cellular responses to stress | 0.047495 | 1.323 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.040174 | 1.396 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.048736 | 1.312 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.048309 | 1.316 |
| R-HSA-3371556 | Cellular response to heat stress | 0.044008 | 1.356 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.048818 | 1.311 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.042363 | 1.373 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.052640 | 1.279 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.041503 | 1.382 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.045525 | 1.342 |
| R-HSA-69190 | DNA strand elongation | 0.053629 | 1.271 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.056831 | 1.245 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.058695 | 1.231 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.058593 | 1.232 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.065985 | 1.181 |
| R-HSA-165158 | Activation of AKT2 | 0.065985 | 1.181 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.058687 | 1.231 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.058687 | 1.231 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.056138 | 1.251 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.056138 | 1.251 |
| R-HSA-9909396 | Circadian clock | 0.057837 | 1.238 |
| R-HSA-9930044 | Nuclear RNA decay | 0.056138 | 1.251 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.055628 | 1.255 |
| R-HSA-9843745 | Adipogenesis | 0.056700 | 1.246 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.064067 | 1.193 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.056138 | 1.251 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.065985 | 1.181 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.056138 | 1.251 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.063183 | 1.199 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.057152 | 1.243 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.061276 | 1.213 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.060258 | 1.220 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.067376 | 1.171 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.075052 | 1.125 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.092923 | 1.032 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.101729 | 0.993 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.101729 | 0.993 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.101729 | 0.993 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.110451 | 0.957 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.127642 | 0.894 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.136114 | 0.866 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.161041 | 0.793 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.169190 | 0.772 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.177261 | 0.751 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.177261 | 0.751 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.193169 | 0.714 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.074779 | 1.126 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.077585 | 1.110 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.208771 | 0.680 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.208771 | 0.680 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.216460 | 0.665 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.216460 | 0.665 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.224074 | 0.650 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.098092 | 1.008 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.231615 | 0.635 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.231615 | 0.635 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.231615 | 0.635 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.239082 | 0.621 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.246478 | 0.608 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.246478 | 0.608 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.246478 | 0.608 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.116729 | 0.933 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.116729 | 0.933 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.119917 | 0.921 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.136168 | 0.866 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.275354 | 0.560 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.275354 | 0.560 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.113404 | 0.945 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.187329 | 0.727 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.233460 | 0.632 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.233460 | 0.632 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.258602 | 0.587 |
| R-HSA-1989781 | PPARA activates gene expression | 0.238821 | 0.622 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.093054 | 1.031 |
| R-HSA-72172 | mRNA Splicing | 0.069411 | 1.159 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.239082 | 0.621 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.268239 | 0.571 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.144504 | 0.840 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.185253 | 0.732 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.275354 | 0.560 |
| R-HSA-202424 | Downstream TCR signaling | 0.251410 | 0.600 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.134788 | 0.870 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.095398 | 1.020 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.161041 | 0.793 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.193169 | 0.714 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.134788 | 0.870 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.190835 | 0.719 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.205781 | 0.687 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.262201 | 0.581 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.107300 | 0.969 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.231615 | 0.635 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.204942 | 0.688 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.107265 | 0.970 |
| R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.275354 | 0.560 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.142800 | 0.845 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.142800 | 0.845 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.142800 | 0.845 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.142800 | 0.845 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 0.075052 | 1.125 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.136114 | 0.866 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.169190 | 0.772 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.177261 | 0.751 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.185253 | 0.732 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.201008 | 0.697 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.208771 | 0.680 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.083293 | 1.079 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.086194 | 1.065 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.239082 | 0.621 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.253802 | 0.596 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.253802 | 0.596 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.146142 | 0.835 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.197873 | 0.704 |
| R-HSA-6807070 | PTEN Regulation | 0.195839 | 0.708 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.084498 | 1.073 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.075182 | 1.124 |
| R-HSA-162587 | HIV Life Cycle | 0.093054 | 1.031 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.101729 | 0.993 |
| R-HSA-9620244 | Long-term potentiation | 0.261056 | 0.583 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.075052 | 1.125 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.169190 | 0.772 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.193169 | 0.714 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.139476 | 0.856 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.089246 | 1.049 |
| R-HSA-68882 | Mitotic Anaphase | 0.082390 | 1.084 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.219161 | 0.659 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.083526 | 1.078 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.123926 | 0.907 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.238821 | 0.622 |
| R-HSA-162906 | HIV Infection | 0.222023 | 0.654 |
| R-HSA-8964046 | VLDL clearance | 0.092923 | 1.032 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.092923 | 1.032 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.185253 | 0.732 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.201008 | 0.697 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.216460 | 0.665 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.275354 | 0.560 |
| R-HSA-69239 | Synthesis of DNA | 0.111343 | 0.953 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.113404 | 0.945 |
| R-HSA-180786 | Extension of Telomeres | 0.139476 | 0.856 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.069270 | 1.159 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.136114 | 0.866 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.268239 | 0.571 |
| R-HSA-157579 | Telomere Maintenance | 0.089680 | 1.047 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.144045 | 0.842 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.212040 | 0.674 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.080423 | 1.095 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.216460 | 0.665 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.117766 | 0.929 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.142800 | 0.845 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.197873 | 0.704 |
| R-HSA-73886 | Chromosome Maintenance | 0.145966 | 0.836 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.166915 | 0.778 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.075052 | 1.125 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.092923 | 1.032 |
| R-HSA-444257 | RSK activation | 0.101729 | 0.993 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.110451 | 0.957 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.119088 | 0.924 |
| R-HSA-69091 | Polymerase switching | 0.144504 | 0.840 |
| R-HSA-69109 | Leading Strand Synthesis | 0.144504 | 0.840 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.152812 | 0.816 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.231615 | 0.635 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.246478 | 0.608 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.261056 | 0.583 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.136168 | 0.866 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.083293 | 1.079 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.144504 | 0.840 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.098092 | 1.008 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.172599 | 0.763 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.261056 | 0.583 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.134059 | 0.873 |
| R-HSA-448706 | Interleukin-1 processing | 0.110451 | 0.957 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.110451 | 0.957 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.127642 | 0.894 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.144504 | 0.840 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.144504 | 0.840 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.144504 | 0.840 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.169190 | 0.772 |
| R-HSA-3371568 | Attenuation phase | 0.077585 | 1.110 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.113563 | 0.945 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.159663 | 0.797 |
| R-HSA-211000 | Gene Silencing by RNA | 0.111343 | 0.953 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.226302 | 0.645 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.139222 | 0.856 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.163354 | 0.787 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.185253 | 0.732 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.193169 | 0.714 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.201008 | 0.697 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.084113 | 1.075 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.255005 | 0.593 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.261056 | 0.583 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.268239 | 0.571 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.201404 | 0.696 |
| R-HSA-69242 | S Phase | 0.220905 | 0.656 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.116144 | 0.935 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.121559 | 0.915 |
| R-HSA-1640170 | Cell Cycle | 0.101342 | 0.994 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.169190 | 0.772 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.261056 | 0.583 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.268239 | 0.571 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.240633 | 0.619 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.261056 | 0.583 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.261056 | 0.583 |
| R-HSA-373752 | Netrin-1 signaling | 0.092086 | 1.036 |
| R-HSA-373755 | Semaphorin interactions | 0.152872 | 0.816 |
| R-HSA-8854214 | TBC/RABGAPs | 0.089125 | 1.050 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.233460 | 0.632 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.164450 | 0.784 |
| R-HSA-69306 | DNA Replication | 0.233675 | 0.631 |
| R-HSA-2028269 | Signaling by Hippo | 0.193169 | 0.714 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.201008 | 0.697 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.190835 | 0.719 |
| R-HSA-73884 | Base Excision Repair | 0.073450 | 1.134 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.092923 | 1.032 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.113563 | 0.945 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.261056 | 0.583 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.251769 | 0.599 |
| R-HSA-201556 | Signaling by ALK | 0.074779 | 1.126 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.144504 | 0.840 |
| R-HSA-9833110 | RSV-host interactions | 0.105248 | 0.978 |
| R-HSA-1266738 | Developmental Biology | 0.147011 | 0.833 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.197958 | 0.703 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.193169 | 0.714 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.231615 | 0.635 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.229879 | 0.639 |
| R-HSA-9675108 | Nervous system development | 0.072007 | 1.143 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.253802 | 0.596 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.253802 | 0.596 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.224077 | 0.650 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.154563 | 0.811 |
| R-HSA-166520 | Signaling by NTRKs | 0.220905 | 0.656 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.261056 | 0.583 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.275354 | 0.560 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.126358 | 0.898 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.275354 | 0.560 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.152872 | 0.816 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.146142 | 0.835 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.261056 | 0.583 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.116729 | 0.933 |
| R-HSA-177929 | Signaling by EGFR | 0.129609 | 0.887 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.208488 | 0.681 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.208771 | 0.680 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.136999 | 0.863 |
| R-HSA-422475 | Axon guidance | 0.189460 | 0.722 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.168007 | 0.775 |
| R-HSA-8964038 | LDL clearance | 0.239082 | 0.621 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.190835 | 0.719 |
| R-HSA-186712 | Regulation of beta-cell development | 0.139476 | 0.856 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.190914 | 0.719 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.236246 | 0.627 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.224074 | 0.650 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.122691 | 0.911 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.092086 | 1.036 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.280188 | 0.553 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.282399 | 0.549 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.282399 | 0.549 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.282399 | 0.549 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.282399 | 0.549 |
| R-HSA-622312 | Inflammasomes | 0.282399 | 0.549 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.283784 | 0.547 |
| R-HSA-72086 | mRNA Capping | 0.289376 | 0.539 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.289376 | 0.539 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.289376 | 0.539 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.289376 | 0.539 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.296286 | 0.528 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.296286 | 0.528 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.296286 | 0.528 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.296286 | 0.528 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.301731 | 0.520 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.301731 | 0.520 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.303129 | 0.518 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.303129 | 0.518 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.303129 | 0.518 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.303129 | 0.518 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.303129 | 0.518 |
| R-HSA-168255 | Influenza Infection | 0.304385 | 0.517 |
| R-HSA-2559583 | Cellular Senescence | 0.307037 | 0.513 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.308890 | 0.510 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.309906 | 0.509 |
| R-HSA-73894 | DNA Repair | 0.313032 | 0.504 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.316618 | 0.499 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.316618 | 0.499 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.316618 | 0.499 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.316618 | 0.499 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.316618 | 0.499 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.316618 | 0.499 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.316618 | 0.499 |
| R-HSA-354192 | Integrin signaling | 0.316618 | 0.499 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.316618 | 0.499 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.323264 | 0.490 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.323264 | 0.490 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.323264 | 0.490 |
| R-HSA-5673000 | RAF activation | 0.329847 | 0.482 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.329847 | 0.482 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.329847 | 0.482 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.329847 | 0.482 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.329847 | 0.482 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.329847 | 0.482 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.329847 | 0.482 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.329847 | 0.482 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.330275 | 0.481 |
| R-HSA-202403 | TCR signaling | 0.333823 | 0.476 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.336366 | 0.473 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.336366 | 0.473 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.336366 | 0.473 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.336366 | 0.473 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.336366 | 0.473 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.340902 | 0.467 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.340902 | 0.467 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.340902 | 0.467 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.342821 | 0.465 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.342821 | 0.465 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.342821 | 0.465 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.342821 | 0.465 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.342821 | 0.465 |
| R-HSA-8853659 | RET signaling | 0.342821 | 0.465 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.342821 | 0.465 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.347958 | 0.458 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.349215 | 0.457 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.349215 | 0.457 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.349215 | 0.457 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.354989 | 0.450 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.355546 | 0.449 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.355546 | 0.449 |
| R-HSA-68886 | M Phase | 0.357136 | 0.447 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.358495 | 0.446 |
| R-HSA-913531 | Interferon Signaling | 0.359063 | 0.445 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.361817 | 0.442 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.361817 | 0.442 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.361817 | 0.442 |
| R-HSA-71336 | Pentose phosphate pathway | 0.361817 | 0.442 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.361817 | 0.442 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.361817 | 0.442 |
| R-HSA-212436 | Generic Transcription Pathway | 0.364985 | 0.438 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.368026 | 0.434 |
| R-HSA-167169 | HIV Transcription Elongation | 0.368026 | 0.434 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.368026 | 0.434 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.368026 | 0.434 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.368026 | 0.434 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.368026 | 0.434 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.368026 | 0.434 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.368026 | 0.434 |
| R-HSA-5260271 | Diseases of Immune System | 0.368026 | 0.434 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.368026 | 0.434 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.374176 | 0.427 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.374176 | 0.427 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.374176 | 0.427 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.379380 | 0.421 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.380266 | 0.420 |
| R-HSA-167161 | HIV Transcription Initiation | 0.380266 | 0.420 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.380266 | 0.420 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.380266 | 0.420 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.380266 | 0.420 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.380266 | 0.420 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.380266 | 0.420 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.380266 | 0.420 |
| R-HSA-109582 | Hemostasis | 0.385741 | 0.414 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.386298 | 0.413 |
| R-HSA-73928 | Depyrimidination | 0.386298 | 0.413 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.392271 | 0.406 |
| R-HSA-194138 | Signaling by VEGF | 0.396567 | 0.402 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.398186 | 0.400 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.398186 | 0.400 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.404044 | 0.394 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.404044 | 0.394 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.404044 | 0.394 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.404044 | 0.394 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.404044 | 0.394 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.404044 | 0.394 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.409845 | 0.387 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.409845 | 0.387 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.409845 | 0.387 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.409845 | 0.387 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.409845 | 0.387 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.409845 | 0.387 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.409845 | 0.387 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.409845 | 0.387 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.409845 | 0.387 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.409845 | 0.387 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.415590 | 0.381 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.415590 | 0.381 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.421280 | 0.375 |
| R-HSA-73893 | DNA Damage Bypass | 0.426915 | 0.370 |
| R-HSA-109704 | PI3K Cascade | 0.432495 | 0.364 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.432495 | 0.364 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.438021 | 0.359 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.440183 | 0.356 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.443494 | 0.353 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.443494 | 0.353 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.443494 | 0.353 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.443494 | 0.353 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.448913 | 0.348 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.448913 | 0.348 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.448913 | 0.348 |
| R-HSA-1221632 | Meiotic synapsis | 0.448913 | 0.348 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.454281 | 0.343 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.454281 | 0.343 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.454281 | 0.343 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.459596 | 0.338 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.462954 | 0.334 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.464860 | 0.333 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.464860 | 0.333 |
| R-HSA-5578775 | Ion homeostasis | 0.464860 | 0.333 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.464860 | 0.333 |
| R-HSA-75893 | TNF signaling | 0.464860 | 0.333 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.466163 | 0.331 |
| R-HSA-157118 | Signaling by NOTCH | 0.466224 | 0.331 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.469361 | 0.328 |
| R-HSA-112399 | IRS-mediated signalling | 0.470073 | 0.328 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.470073 | 0.328 |
| R-HSA-1483166 | Synthesis of PA | 0.470073 | 0.328 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.470073 | 0.328 |
| R-HSA-199991 | Membrane Trafficking | 0.478767 | 0.320 |
| R-HSA-191859 | snRNP Assembly | 0.480348 | 0.318 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.480348 | 0.318 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.480348 | 0.318 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.481554 | 0.317 |
| R-HSA-9758941 | Gastrulation | 0.485178 | 0.314 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.485411 | 0.314 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.485757 | 0.314 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.490424 | 0.309 |
| R-HSA-9679506 | SARS-CoV Infections | 0.492726 | 0.307 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.494529 | 0.306 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.495390 | 0.305 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.495390 | 0.305 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.497622 | 0.303 |
| R-HSA-8848021 | Signaling by PTK6 | 0.500307 | 0.301 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.500307 | 0.301 |
| R-HSA-5688426 | Deubiquitination | 0.503198 | 0.298 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.505177 | 0.297 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.505177 | 0.297 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.505177 | 0.297 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.510000 | 0.292 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.510000 | 0.292 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.510000 | 0.292 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.510438 | 0.292 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.512907 | 0.290 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.514775 | 0.288 |
| R-HSA-877300 | Interferon gamma signaling | 0.515927 | 0.287 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.518935 | 0.285 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.519505 | 0.284 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.519505 | 0.284 |
| R-HSA-167172 | Transcription of the HIV genome | 0.524189 | 0.281 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.524189 | 0.281 |
| R-HSA-5218859 | Regulated Necrosis | 0.524189 | 0.281 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.533421 | 0.273 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.533421 | 0.273 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.537970 | 0.269 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.537970 | 0.269 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.542475 | 0.266 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.546936 | 0.262 |
| R-HSA-4086398 | Ca2+ pathway | 0.546936 | 0.262 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.546936 | 0.262 |
| R-HSA-72306 | tRNA processing | 0.551199 | 0.259 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.555729 | 0.255 |
| R-HSA-8852135 | Protein ubiquitination | 0.555729 | 0.255 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.555729 | 0.255 |
| R-HSA-5689603 | UCH proteinases | 0.560062 | 0.252 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.560062 | 0.252 |
| R-HSA-9824446 | Viral Infection Pathways | 0.568102 | 0.246 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.568602 | 0.245 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.568602 | 0.245 |
| R-HSA-4086400 | PCP/CE pathway | 0.568602 | 0.245 |
| R-HSA-9659379 | Sensory processing of sound | 0.572810 | 0.242 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.576977 | 0.239 |
| R-HSA-6806834 | Signaling by MET | 0.576977 | 0.239 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.576977 | 0.239 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.593246 | 0.227 |
| R-HSA-69275 | G2/M Transition | 0.595374 | 0.225 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.597216 | 0.224 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.597216 | 0.224 |
| R-HSA-1500620 | Meiosis | 0.597216 | 0.224 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.600663 | 0.221 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.605039 | 0.218 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.608894 | 0.215 |
| R-HSA-156902 | Peptide chain elongation | 0.612711 | 0.213 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.612711 | 0.213 |
| R-HSA-68877 | Mitotic Prometaphase | 0.613660 | 0.212 |
| R-HSA-9609690 | HCMV Early Events | 0.621303 | 0.207 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.621303 | 0.207 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.623943 | 0.205 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.631250 | 0.200 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.631250 | 0.200 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.631250 | 0.200 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.631250 | 0.200 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.634850 | 0.197 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.634850 | 0.197 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.638686 | 0.195 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.638686 | 0.195 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.638686 | 0.195 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.641947 | 0.193 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.645444 | 0.190 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.645444 | 0.190 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.646361 | 0.190 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.648907 | 0.188 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.652336 | 0.186 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.655732 | 0.183 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.655732 | 0.183 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.655732 | 0.183 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.655732 | 0.183 |
| R-HSA-190236 | Signaling by FGFR | 0.655732 | 0.183 |
| R-HSA-70171 | Glycolysis | 0.662425 | 0.179 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.662431 | 0.179 |
| R-HSA-397014 | Muscle contraction | 0.662431 | 0.179 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.665723 | 0.177 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.665723 | 0.177 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.665723 | 0.177 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.668989 | 0.175 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.668989 | 0.175 |
| R-HSA-192823 | Viral mRNA Translation | 0.672223 | 0.172 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.675426 | 0.170 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.675426 | 0.170 |
| R-HSA-418990 | Adherens junctions interactions | 0.676071 | 0.170 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.681739 | 0.166 |
| R-HSA-418346 | Platelet homeostasis | 0.684849 | 0.164 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.687930 | 0.162 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.690980 | 0.161 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.690980 | 0.161 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.694001 | 0.159 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.694001 | 0.159 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.696992 | 0.157 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.696992 | 0.157 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.703196 | 0.153 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.705793 | 0.151 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.708670 | 0.150 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.711519 | 0.148 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.714340 | 0.146 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.716341 | 0.145 |
| R-HSA-1280218 | Adaptive Immune System | 0.719208 | 0.143 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.720327 | 0.142 |
| R-HSA-70326 | Glucose metabolism | 0.722640 | 0.141 |
| R-HSA-5693538 | Homology Directed Repair | 0.725353 | 0.139 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.728040 | 0.138 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.728040 | 0.138 |
| R-HSA-68875 | Mitotic Prophase | 0.730700 | 0.136 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.735944 | 0.133 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.735944 | 0.133 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.741087 | 0.130 |
| R-HSA-9609646 | HCMV Infection | 0.741423 | 0.130 |
| R-HSA-421270 | Cell-cell junction organization | 0.743273 | 0.129 |
| R-HSA-1474165 | Reproduction | 0.760680 | 0.119 |
| R-HSA-5576891 | Cardiac conduction | 0.763023 | 0.117 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.765344 | 0.116 |
| R-HSA-416476 | G alpha (q) signalling events | 0.766305 | 0.116 |
| R-HSA-163685 | Integration of energy metabolism | 0.776611 | 0.110 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.780966 | 0.107 |
| R-HSA-9664407 | Parasite infection | 0.785237 | 0.105 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.785237 | 0.105 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.785237 | 0.105 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.787341 | 0.104 |
| R-HSA-1632852 | Macroautophagy | 0.787341 | 0.104 |
| R-HSA-446728 | Cell junction organization | 0.789095 | 0.103 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.793718 | 0.100 |
| R-HSA-9658195 | Leishmania infection | 0.793718 | 0.100 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.795239 | 0.100 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.801508 | 0.096 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.803453 | 0.095 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.805614 | 0.094 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.811049 | 0.091 |
| R-HSA-1483257 | Phospholipid metabolism | 0.814135 | 0.089 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.815522 | 0.089 |
| R-HSA-72766 | Translation | 0.817384 | 0.088 |
| R-HSA-9612973 | Autophagy | 0.818352 | 0.087 |
| R-HSA-9610379 | HCMV Late Events | 0.820134 | 0.086 |
| R-HSA-9711097 | Cellular response to starvation | 0.821898 | 0.085 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.832128 | 0.080 |
| R-HSA-5619102 | SLC transporter disorders | 0.837022 | 0.077 |
| R-HSA-1500931 | Cell-Cell communication | 0.841402 | 0.075 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.843328 | 0.074 |
| R-HSA-6798695 | Neutrophil degranulation | 0.847767 | 0.072 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.847897 | 0.072 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.847897 | 0.072 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.847897 | 0.072 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.849391 | 0.071 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.849658 | 0.071 |
| R-HSA-8957322 | Metabolism of steroids | 0.850805 | 0.070 |
| R-HSA-112316 | Neuronal System | 0.858456 | 0.066 |
| R-HSA-1474244 | Extracellular matrix organization | 0.858617 | 0.066 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.868832 | 0.061 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.872662 | 0.059 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.885778 | 0.053 |
| R-HSA-5357801 | Programmed Cell Death | 0.890207 | 0.051 |
| R-HSA-388396 | GPCR downstream signalling | 0.891260 | 0.050 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.906677 | 0.043 |
| R-HSA-1643685 | Disease | 0.910195 | 0.041 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.913417 | 0.039 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.914270 | 0.039 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.914693 | 0.039 |
| R-HSA-72312 | rRNA processing | 0.915951 | 0.038 |
| R-HSA-5663205 | Infectious disease | 0.915996 | 0.038 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.927560 | 0.033 |
| R-HSA-372790 | Signaling by GPCR | 0.933611 | 0.030 |
| R-HSA-5668914 | Diseases of metabolism | 0.934542 | 0.029 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.938191 | 0.028 |
| R-HSA-597592 | Post-translational protein modification | 0.944538 | 0.025 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.944585 | 0.025 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.947976 | 0.023 |
| R-HSA-168249 | Innate Immune System | 0.957086 | 0.019 |
| R-HSA-211859 | Biological oxidations | 0.970559 | 0.013 |
| R-HSA-168256 | Immune System | 0.971722 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.977388 | 0.010 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.982737 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 0.985438 | 0.006 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.987470 | 0.005 |
| R-HSA-449147 | Signaling by Interleukins | 0.987785 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 0.992051 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.997568 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998266 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999958 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999997 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.846 | 0.402 | 1 | 0.868 |
HIPK4 |
0.830 | 0.415 | 1 | 0.817 |
CLK2 |
0.825 | 0.323 | -3 | 0.774 |
COT |
0.823 | 0.152 | 2 | 0.780 |
DYRK2 |
0.823 | 0.315 | 1 | 0.765 |
GRK1 |
0.822 | 0.256 | -2 | 0.798 |
KIS |
0.821 | 0.295 | 1 | 0.763 |
HIPK2 |
0.820 | 0.322 | 1 | 0.696 |
PIM3 |
0.819 | 0.204 | -3 | 0.842 |
DYRK4 |
0.818 | 0.323 | 1 | 0.712 |
SRPK1 |
0.818 | 0.218 | -3 | 0.793 |
MOS |
0.817 | 0.226 | 1 | 0.861 |
SKMLCK |
0.814 | 0.197 | -2 | 0.802 |
NDR2 |
0.813 | 0.206 | -3 | 0.830 |
CDC7 |
0.813 | 0.118 | 1 | 0.849 |
CDKL1 |
0.812 | 0.201 | -3 | 0.823 |
ICK |
0.811 | 0.271 | -3 | 0.848 |
CDKL5 |
0.809 | 0.214 | -3 | 0.817 |
MTOR |
0.809 | 0.098 | 1 | 0.776 |
GRK7 |
0.807 | 0.203 | 1 | 0.768 |
HIPK1 |
0.807 | 0.265 | 1 | 0.778 |
CDK1 |
0.807 | 0.193 | 1 | 0.740 |
NLK |
0.806 | 0.114 | 1 | 0.863 |
CDK18 |
0.806 | 0.227 | 1 | 0.705 |
P38B |
0.805 | 0.257 | 1 | 0.723 |
ERK5 |
0.805 | 0.131 | 1 | 0.832 |
JNK2 |
0.805 | 0.206 | 1 | 0.714 |
RSK2 |
0.805 | 0.153 | -3 | 0.790 |
PRPK |
0.804 | 0.032 | -1 | 0.760 |
IKKB |
0.802 | 0.021 | -2 | 0.704 |
PIM1 |
0.802 | 0.149 | -3 | 0.803 |
CLK4 |
0.802 | 0.197 | -3 | 0.784 |
ATR |
0.802 | 0.073 | 1 | 0.811 |
CDK19 |
0.802 | 0.217 | 1 | 0.713 |
GSK3A |
0.801 | 0.257 | 4 | 0.720 |
SRPK2 |
0.801 | 0.175 | -3 | 0.723 |
P38D |
0.801 | 0.248 | 1 | 0.662 |
CDK8 |
0.801 | 0.187 | 1 | 0.743 |
P90RSK |
0.800 | 0.150 | -3 | 0.797 |
BMPR1B |
0.800 | 0.159 | 1 | 0.837 |
JNK3 |
0.800 | 0.178 | 1 | 0.737 |
MAK |
0.800 | 0.330 | -2 | 0.854 |
DYRK1A |
0.800 | 0.249 | 1 | 0.790 |
PRKD1 |
0.800 | 0.170 | -3 | 0.828 |
IKKA |
0.800 | 0.087 | -2 | 0.712 |
RAF1 |
0.799 | 0.015 | 1 | 0.809 |
P38A |
0.799 | 0.230 | 1 | 0.777 |
ERK1 |
0.799 | 0.206 | 1 | 0.712 |
RSK4 |
0.798 | 0.173 | -3 | 0.771 |
PASK |
0.798 | 0.292 | -3 | 0.863 |
GRK5 |
0.797 | 0.038 | -3 | 0.822 |
CDK7 |
0.797 | 0.165 | 1 | 0.761 |
LATS1 |
0.796 | 0.198 | -3 | 0.827 |
CAMK1B |
0.796 | 0.036 | -3 | 0.841 |
AURC |
0.796 | 0.106 | -2 | 0.560 |
CDK5 |
0.796 | 0.156 | 1 | 0.778 |
CLK1 |
0.796 | 0.185 | -3 | 0.755 |
CHAK2 |
0.796 | 0.050 | -1 | 0.753 |
CDK3 |
0.795 | 0.164 | 1 | 0.682 |
DAPK2 |
0.795 | 0.090 | -3 | 0.845 |
P38G |
0.795 | 0.177 | 1 | 0.657 |
TBK1 |
0.795 | 0.020 | 1 | 0.690 |
SRPK3 |
0.794 | 0.126 | -3 | 0.768 |
DYRK1B |
0.794 | 0.219 | 1 | 0.736 |
CAMLCK |
0.794 | 0.053 | -2 | 0.763 |
CDK17 |
0.794 | 0.180 | 1 | 0.663 |
PRKD2 |
0.794 | 0.142 | -3 | 0.782 |
RIPK3 |
0.793 | -0.014 | 3 | 0.560 |
GRK6 |
0.793 | 0.053 | 1 | 0.832 |
GSK3B |
0.793 | 0.212 | 4 | 0.715 |
BMPR2 |
0.793 | -0.072 | -2 | 0.802 |
NUAK2 |
0.792 | 0.048 | -3 | 0.836 |
NDR1 |
0.792 | 0.052 | -3 | 0.817 |
CAMK2A |
0.792 | 0.139 | 2 | 0.684 |
CAMK2G |
0.791 | -0.064 | 2 | 0.674 |
CDK13 |
0.791 | 0.128 | 1 | 0.734 |
IKKE |
0.791 | -0.011 | 1 | 0.688 |
NIK |
0.790 | -0.010 | -3 | 0.840 |
HIPK3 |
0.790 | 0.219 | 1 | 0.760 |
DYRK3 |
0.790 | 0.198 | 1 | 0.768 |
DSTYK |
0.789 | -0.082 | 2 | 0.773 |
MARK4 |
0.789 | 0.012 | 4 | 0.774 |
MSK1 |
0.789 | 0.123 | -3 | 0.772 |
PDHK4 |
0.789 | -0.167 | 1 | 0.821 |
RSK3 |
0.789 | 0.084 | -3 | 0.784 |
LATS2 |
0.789 | 0.068 | -5 | 0.693 |
MAPKAPK2 |
0.789 | 0.119 | -3 | 0.747 |
CDK14 |
0.789 | 0.172 | 1 | 0.742 |
WNK1 |
0.788 | -0.030 | -2 | 0.841 |
PRP4 |
0.788 | 0.178 | -3 | 0.767 |
DLK |
0.788 | 0.038 | 1 | 0.802 |
MLK1 |
0.788 | -0.066 | 2 | 0.691 |
PKACG |
0.788 | 0.048 | -2 | 0.651 |
PKACB |
0.788 | 0.109 | -2 | 0.571 |
PKN3 |
0.788 | 0.009 | -3 | 0.819 |
JNK1 |
0.787 | 0.160 | 1 | 0.710 |
CDK10 |
0.787 | 0.165 | 1 | 0.731 |
P70S6KB |
0.787 | 0.058 | -3 | 0.792 |
PKN2 |
0.787 | -0.004 | -3 | 0.817 |
MASTL |
0.786 | -0.069 | -2 | 0.767 |
CAMK2B |
0.786 | 0.077 | 2 | 0.659 |
CDK12 |
0.786 | 0.128 | 1 | 0.709 |
TGFBR1 |
0.786 | 0.065 | -2 | 0.729 |
PKCD |
0.786 | 0.024 | 2 | 0.658 |
MST4 |
0.786 | -0.038 | 2 | 0.720 |
HUNK |
0.785 | -0.064 | 2 | 0.737 |
MLK2 |
0.785 | 0.024 | 2 | 0.686 |
CAMK2D |
0.785 | 0.037 | -3 | 0.817 |
MLK3 |
0.785 | 0.023 | 2 | 0.621 |
CDK16 |
0.785 | 0.171 | 1 | 0.676 |
CK1E |
0.784 | 0.087 | -3 | 0.632 |
AMPKA1 |
0.784 | 0.003 | -3 | 0.834 |
GRK2 |
0.784 | 0.066 | -2 | 0.698 |
PRKX |
0.784 | 0.119 | -3 | 0.706 |
GCN2 |
0.784 | -0.105 | 2 | 0.658 |
PAK1 |
0.784 | 0.029 | -2 | 0.723 |
ALK4 |
0.783 | 0.022 | -2 | 0.755 |
ULK2 |
0.783 | -0.170 | 2 | 0.649 |
MAPKAPK3 |
0.783 | 0.067 | -3 | 0.776 |
GRK4 |
0.783 | -0.025 | -2 | 0.790 |
ERK2 |
0.782 | 0.124 | 1 | 0.747 |
MSK2 |
0.782 | 0.065 | -3 | 0.780 |
TGFBR2 |
0.782 | -0.055 | -2 | 0.693 |
AMPKA2 |
0.781 | 0.032 | -3 | 0.808 |
DRAK1 |
0.780 | 0.095 | 1 | 0.794 |
CDK9 |
0.780 | 0.108 | 1 | 0.737 |
PKCB |
0.780 | 0.018 | 2 | 0.614 |
FAM20C |
0.779 | -0.005 | 2 | 0.520 |
QSK |
0.779 | 0.039 | 4 | 0.745 |
NEK6 |
0.779 | -0.094 | -2 | 0.769 |
CK1D |
0.779 | 0.093 | -3 | 0.584 |
MPSK1 |
0.779 | 0.179 | 1 | 0.766 |
ACVR2B |
0.779 | 0.043 | -2 | 0.702 |
AKT2 |
0.778 | 0.088 | -3 | 0.726 |
MYLK4 |
0.778 | 0.038 | -2 | 0.678 |
PKCA |
0.778 | 0.022 | 2 | 0.604 |
PKCG |
0.778 | 0.004 | 2 | 0.624 |
RIPK1 |
0.778 | -0.117 | 1 | 0.759 |
TSSK1 |
0.777 | 0.000 | -3 | 0.849 |
VRK2 |
0.777 | -0.043 | 1 | 0.834 |
PDHK1 |
0.777 | -0.210 | 1 | 0.797 |
MNK1 |
0.777 | 0.040 | -2 | 0.697 |
CDK2 |
0.777 | 0.050 | 1 | 0.802 |
BMPR1A |
0.777 | 0.076 | 1 | 0.808 |
MARK3 |
0.777 | 0.044 | 4 | 0.715 |
NIM1 |
0.776 | -0.073 | 3 | 0.615 |
NEK7 |
0.776 | -0.201 | -3 | 0.809 |
PIM2 |
0.776 | 0.095 | -3 | 0.761 |
AURB |
0.776 | 0.024 | -2 | 0.556 |
MEK1 |
0.776 | -0.074 | 2 | 0.737 |
TSSK2 |
0.776 | -0.049 | -5 | 0.763 |
YSK4 |
0.775 | -0.020 | 1 | 0.734 |
PKR |
0.775 | -0.046 | 1 | 0.800 |
MOK |
0.775 | 0.231 | 1 | 0.778 |
GRK3 |
0.775 | 0.064 | -2 | 0.668 |
PAK3 |
0.775 | -0.024 | -2 | 0.707 |
ULK1 |
0.775 | -0.152 | -3 | 0.765 |
PKCZ |
0.774 | -0.004 | 2 | 0.643 |
ATM |
0.774 | -0.030 | 1 | 0.749 |
ALK2 |
0.774 | 0.019 | -2 | 0.735 |
MST3 |
0.774 | 0.031 | 2 | 0.734 |
MLK4 |
0.774 | -0.056 | 2 | 0.604 |
IRE1 |
0.774 | -0.094 | 1 | 0.743 |
ACVR2A |
0.774 | 0.006 | -2 | 0.683 |
PLK1 |
0.774 | -0.068 | -2 | 0.692 |
CK1A2 |
0.773 | 0.067 | -3 | 0.589 |
TLK2 |
0.773 | -0.010 | 1 | 0.756 |
DNAPK |
0.773 | 0.026 | 1 | 0.686 |
ANKRD3 |
0.773 | -0.184 | 1 | 0.810 |
MNK2 |
0.773 | -0.002 | -2 | 0.694 |
SMG1 |
0.772 | -0.035 | 1 | 0.759 |
SGK3 |
0.772 | 0.045 | -3 | 0.769 |
NEK9 |
0.772 | -0.167 | 2 | 0.682 |
AURA |
0.772 | 0.019 | -2 | 0.532 |
PKG2 |
0.772 | 0.021 | -2 | 0.574 |
PRKD3 |
0.771 | 0.048 | -3 | 0.762 |
GAK |
0.771 | 0.106 | 1 | 0.840 |
WNK3 |
0.771 | -0.230 | 1 | 0.766 |
PAK2 |
0.770 | -0.032 | -2 | 0.703 |
BRSK1 |
0.770 | 0.020 | -3 | 0.787 |
DCAMKL1 |
0.769 | 0.037 | -3 | 0.785 |
TTBK2 |
0.769 | -0.159 | 2 | 0.564 |
SIK |
0.769 | 0.007 | -3 | 0.761 |
BCKDK |
0.768 | -0.176 | -1 | 0.638 |
PKCH |
0.768 | -0.041 | 2 | 0.599 |
CAMK4 |
0.767 | -0.078 | -3 | 0.796 |
QIK |
0.767 | -0.096 | -3 | 0.809 |
MEKK3 |
0.767 | -0.085 | 1 | 0.768 |
GCK |
0.766 | 0.118 | 1 | 0.792 |
CK2A2 |
0.766 | 0.059 | 1 | 0.766 |
MELK |
0.766 | -0.041 | -3 | 0.786 |
TAO3 |
0.766 | 0.007 | 1 | 0.765 |
DAPK3 |
0.766 | 0.060 | -3 | 0.803 |
MARK2 |
0.766 | -0.021 | 4 | 0.678 |
DAPK1 |
0.766 | 0.074 | -3 | 0.800 |
IRE2 |
0.765 | -0.106 | 2 | 0.629 |
CK1G1 |
0.765 | 0.030 | -3 | 0.604 |
NUAK1 |
0.765 | -0.028 | -3 | 0.775 |
CHAK1 |
0.765 | -0.123 | 2 | 0.638 |
PKACA |
0.764 | 0.061 | -2 | 0.514 |
PLK3 |
0.764 | -0.068 | 2 | 0.682 |
CK2A1 |
0.764 | 0.087 | 1 | 0.752 |
BRSK2 |
0.763 | -0.024 | -3 | 0.789 |
BUB1 |
0.763 | 0.206 | -5 | 0.724 |
MEK5 |
0.763 | -0.157 | 2 | 0.703 |
LKB1 |
0.763 | 0.047 | -3 | 0.795 |
SMMLCK |
0.762 | 0.004 | -3 | 0.809 |
PHKG1 |
0.762 | -0.048 | -3 | 0.812 |
NEK5 |
0.762 | -0.075 | 1 | 0.779 |
CDK6 |
0.762 | 0.097 | 1 | 0.717 |
MEKK2 |
0.762 | -0.116 | 2 | 0.671 |
MARK1 |
0.762 | -0.033 | 4 | 0.719 |
CAMK1G |
0.761 | -0.003 | -3 | 0.768 |
NEK11 |
0.761 | -0.045 | 1 | 0.759 |
SSTK |
0.760 | -0.031 | 4 | 0.715 |
NEK2 |
0.760 | -0.146 | 2 | 0.658 |
PAK6 |
0.759 | -0.029 | -2 | 0.615 |
CDK4 |
0.759 | 0.103 | 1 | 0.701 |
BRAF |
0.759 | -0.135 | -4 | 0.746 |
ERK7 |
0.759 | 0.013 | 2 | 0.429 |
WNK4 |
0.758 | -0.110 | -2 | 0.840 |
ROCK2 |
0.758 | 0.087 | -3 | 0.783 |
PKCE |
0.758 | 0.011 | 2 | 0.611 |
CHK1 |
0.757 | -0.045 | -3 | 0.784 |
ZAK |
0.757 | -0.144 | 1 | 0.731 |
SGK1 |
0.757 | 0.087 | -3 | 0.661 |
PLK4 |
0.757 | -0.135 | 2 | 0.540 |
AKT1 |
0.757 | 0.033 | -3 | 0.734 |
HPK1 |
0.756 | 0.033 | 1 | 0.775 |
P70S6K |
0.756 | 0.030 | -3 | 0.723 |
MAPKAPK5 |
0.756 | -0.032 | -3 | 0.740 |
PDK1 |
0.756 | -0.040 | 1 | 0.740 |
MEKK1 |
0.755 | -0.173 | 1 | 0.758 |
DCAMKL2 |
0.754 | -0.036 | -3 | 0.792 |
IRAK4 |
0.754 | -0.139 | 1 | 0.737 |
PKCT |
0.753 | -0.050 | 2 | 0.600 |
PERK |
0.753 | -0.158 | -2 | 0.740 |
MST2 |
0.753 | -0.051 | 1 | 0.778 |
CAMKK2 |
0.753 | -0.061 | -2 | 0.678 |
MAP3K15 |
0.753 | -0.007 | 1 | 0.712 |
CK1A |
0.752 | 0.080 | -3 | 0.502 |
TNIK |
0.752 | -0.007 | 3 | 0.697 |
PINK1 |
0.752 | -0.160 | 1 | 0.828 |
PBK |
0.752 | 0.069 | 1 | 0.759 |
TAK1 |
0.751 | -0.054 | 1 | 0.789 |
AKT3 |
0.751 | 0.060 | -3 | 0.683 |
KHS2 |
0.751 | 0.029 | 1 | 0.775 |
KHS1 |
0.751 | 0.042 | 1 | 0.747 |
SNRK |
0.751 | -0.178 | 2 | 0.575 |
MEKK6 |
0.751 | -0.061 | 1 | 0.753 |
PLK2 |
0.751 | -0.007 | -3 | 0.743 |
CAMKK1 |
0.751 | -0.131 | -2 | 0.683 |
PKCI |
0.750 | -0.063 | 2 | 0.617 |
TLK1 |
0.750 | -0.144 | -2 | 0.754 |
MRCKA |
0.750 | 0.045 | -3 | 0.746 |
MINK |
0.749 | -0.065 | 1 | 0.755 |
EEF2K |
0.749 | -0.079 | 3 | 0.616 |
SLK |
0.748 | 0.012 | -2 | 0.653 |
NEK8 |
0.748 | -0.169 | 2 | 0.684 |
CAMK1D |
0.748 | 0.016 | -3 | 0.699 |
LRRK2 |
0.748 | -0.081 | 2 | 0.701 |
TAO2 |
0.748 | -0.123 | 2 | 0.702 |
DMPK1 |
0.748 | 0.074 | -3 | 0.762 |
VRK1 |
0.748 | -0.092 | 2 | 0.745 |
HGK |
0.747 | -0.071 | 3 | 0.683 |
MRCKB |
0.747 | 0.026 | -3 | 0.741 |
YANK3 |
0.746 | -0.011 | 2 | 0.365 |
HASPIN |
0.746 | 0.059 | -1 | 0.710 |
PDHK3_TYR |
0.745 | 0.286 | 4 | 0.852 |
NEK4 |
0.744 | -0.132 | 1 | 0.744 |
SBK |
0.744 | 0.089 | -3 | 0.622 |
CHK2 |
0.743 | 0.033 | -3 | 0.671 |
LOK |
0.743 | -0.040 | -2 | 0.679 |
PAK4 |
0.743 | -0.040 | -2 | 0.568 |
HRI |
0.742 | -0.270 | -2 | 0.748 |
PAK5 |
0.742 | -0.050 | -2 | 0.565 |
MST1 |
0.742 | -0.071 | 1 | 0.756 |
PDHK4_TYR |
0.742 | 0.245 | 2 | 0.788 |
STK33 |
0.742 | -0.118 | 2 | 0.530 |
NEK1 |
0.741 | -0.099 | 1 | 0.746 |
CRIK |
0.740 | 0.088 | -3 | 0.738 |
TTBK1 |
0.738 | -0.190 | 2 | 0.504 |
MAP2K6_TYR |
0.737 | 0.190 | -1 | 0.760 |
OSR1 |
0.737 | -0.037 | 2 | 0.677 |
ROCK1 |
0.736 | 0.030 | -3 | 0.749 |
PHKG2 |
0.735 | -0.117 | -3 | 0.772 |
IRAK1 |
0.734 | -0.299 | -1 | 0.640 |
PKN1 |
0.734 | -0.045 | -3 | 0.737 |
MAP2K4_TYR |
0.733 | 0.131 | -1 | 0.759 |
BMPR2_TYR |
0.732 | 0.088 | -1 | 0.756 |
ALPHAK3 |
0.732 | -0.023 | -1 | 0.653 |
PDHK1_TYR |
0.732 | 0.097 | -1 | 0.769 |
TESK1_TYR |
0.732 | 0.089 | 3 | 0.713 |
CAMK1A |
0.731 | 0.002 | -3 | 0.682 |
MEK2 |
0.731 | -0.219 | 2 | 0.680 |
PKMYT1_TYR |
0.730 | 0.064 | 3 | 0.688 |
YSK1 |
0.730 | -0.149 | 2 | 0.656 |
TTK |
0.730 | -0.101 | -2 | 0.722 |
LIMK2_TYR |
0.728 | 0.107 | -3 | 0.832 |
TXK |
0.728 | 0.157 | 1 | 0.851 |
ASK1 |
0.727 | -0.074 | 1 | 0.698 |
MAP2K7_TYR |
0.726 | -0.041 | 2 | 0.736 |
EPHB4 |
0.725 | 0.117 | -1 | 0.679 |
MYO3B |
0.724 | -0.080 | 2 | 0.674 |
TNK2 |
0.723 | 0.082 | 3 | 0.638 |
ABL2 |
0.723 | 0.145 | -1 | 0.674 |
BIKE |
0.722 | -0.008 | 1 | 0.728 |
EPHA6 |
0.722 | 0.037 | -1 | 0.716 |
RIPK2 |
0.721 | -0.274 | 1 | 0.680 |
FGR |
0.719 | 0.044 | 1 | 0.831 |
PINK1_TYR |
0.719 | -0.140 | 1 | 0.806 |
PKG1 |
0.719 | -0.050 | -2 | 0.480 |
MYO3A |
0.718 | -0.132 | 1 | 0.742 |
ABL1 |
0.718 | 0.118 | -1 | 0.667 |
SRMS |
0.718 | 0.076 | 1 | 0.831 |
YES1 |
0.718 | 0.003 | -1 | 0.752 |
EPHA4 |
0.717 | 0.070 | 2 | 0.717 |
BLK |
0.716 | 0.053 | -1 | 0.732 |
CK1G3 |
0.716 | 0.012 | -3 | 0.459 |
CK1G2 |
0.716 | 0.041 | -3 | 0.536 |
YANK2 |
0.716 | -0.036 | 2 | 0.373 |
FYN |
0.716 | 0.081 | -1 | 0.734 |
LCK |
0.716 | 0.044 | -1 | 0.728 |
CSF1R |
0.715 | 0.019 | 3 | 0.652 |
RET |
0.715 | -0.035 | 1 | 0.751 |
ITK |
0.715 | 0.058 | -1 | 0.670 |
TYRO3 |
0.714 | -0.060 | 3 | 0.649 |
TAO1 |
0.714 | -0.128 | 1 | 0.671 |
NEK3 |
0.714 | -0.218 | 1 | 0.693 |
BMX |
0.713 | 0.043 | -1 | 0.619 |
MST1R |
0.713 | -0.052 | 3 | 0.677 |
AAK1 |
0.712 | 0.048 | 1 | 0.637 |
PTK2B |
0.712 | 0.125 | -1 | 0.654 |
LIMK1_TYR |
0.712 | -0.128 | 2 | 0.702 |
PTK2 |
0.711 | 0.115 | -1 | 0.671 |
EPHB1 |
0.711 | 0.014 | 1 | 0.813 |
FER |
0.711 | -0.066 | 1 | 0.845 |
DDR1 |
0.711 | -0.096 | 4 | 0.760 |
ROS1 |
0.710 | -0.107 | 3 | 0.606 |
MET |
0.710 | 0.024 | 3 | 0.674 |
HCK |
0.710 | -0.039 | -1 | 0.719 |
EPHB2 |
0.710 | 0.031 | -1 | 0.652 |
KIT |
0.709 | -0.014 | 3 | 0.655 |
INSRR |
0.709 | -0.075 | 3 | 0.590 |
EPHB3 |
0.709 | 0.010 | -1 | 0.656 |
JAK2 |
0.709 | -0.089 | 1 | 0.739 |
MERTK |
0.708 | 0.002 | 3 | 0.647 |
TNK1 |
0.706 | -0.013 | 3 | 0.640 |
DDR2 |
0.706 | 0.051 | 3 | 0.575 |
STLK3 |
0.705 | -0.195 | 1 | 0.699 |
SYK |
0.705 | 0.103 | -1 | 0.654 |
KDR |
0.705 | -0.066 | 3 | 0.604 |
JAK3 |
0.705 | -0.104 | 1 | 0.727 |
TYK2 |
0.703 | -0.230 | 1 | 0.741 |
EPHA7 |
0.703 | -0.000 | 2 | 0.695 |
FGFR2 |
0.702 | -0.111 | 3 | 0.637 |
TEC |
0.702 | -0.046 | -1 | 0.614 |
SRC |
0.701 | -0.008 | -1 | 0.721 |
AXL |
0.701 | -0.085 | 3 | 0.640 |
TEK |
0.700 | -0.114 | 3 | 0.594 |
EPHA3 |
0.700 | -0.032 | 2 | 0.672 |
EPHA5 |
0.699 | 0.027 | 2 | 0.700 |
FLT1 |
0.698 | -0.051 | -1 | 0.673 |
LYN |
0.698 | -0.054 | 3 | 0.563 |
FRK |
0.697 | -0.051 | -1 | 0.711 |
JAK1 |
0.697 | -0.081 | 1 | 0.680 |
FGFR3 |
0.697 | -0.087 | 3 | 0.614 |
NEK10_TYR |
0.697 | -0.083 | 1 | 0.634 |
ZAP70 |
0.696 | 0.105 | -1 | 0.600 |
FLT3 |
0.696 | -0.146 | 3 | 0.646 |
EPHA8 |
0.696 | -0.010 | -1 | 0.657 |
MATK |
0.695 | -0.057 | -1 | 0.612 |
WEE1_TYR |
0.694 | -0.120 | -1 | 0.635 |
FGFR1 |
0.694 | -0.156 | 3 | 0.615 |
PDGFRB |
0.694 | -0.189 | 3 | 0.649 |
EPHA1 |
0.693 | -0.057 | 3 | 0.652 |
TNNI3K_TYR |
0.693 | -0.113 | 1 | 0.749 |
ERBB2 |
0.693 | -0.128 | 1 | 0.722 |
BTK |
0.693 | -0.159 | -1 | 0.638 |
ALK |
0.692 | -0.147 | 3 | 0.570 |
CSK |
0.691 | -0.055 | 2 | 0.688 |
LTK |
0.691 | -0.141 | 3 | 0.588 |
NTRK1 |
0.690 | -0.150 | -1 | 0.667 |
EPHA2 |
0.689 | 0.008 | -1 | 0.613 |
PTK6 |
0.689 | -0.180 | -1 | 0.597 |
INSR |
0.688 | -0.149 | 3 | 0.576 |
NTRK3 |
0.688 | -0.102 | -1 | 0.630 |
ERBB4 |
0.688 | -0.012 | 1 | 0.674 |
FGFR4 |
0.688 | -0.063 | -1 | 0.620 |
EGFR |
0.686 | -0.073 | 1 | 0.632 |
PDGFRA |
0.685 | -0.223 | 3 | 0.651 |
FLT4 |
0.682 | -0.194 | 3 | 0.580 |
NTRK2 |
0.682 | -0.210 | 3 | 0.609 |
IGF1R |
0.678 | -0.133 | 3 | 0.529 |
FES |
0.673 | -0.085 | -1 | 0.591 |
MUSK |
0.666 | -0.150 | 1 | 0.619 |