Motif 505 (n=176)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2706 | ochoa | Snf2 related CREBBP activator protein | None |
| A4D2B0 | MBLAC1 | S56 | ochoa | Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) | Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}. |
| A6NHQ4 | EPOP | S180 | ochoa | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}. |
| A6NKT7 | RGPD3 | S1232 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00139 | KIF2A | S100 | ochoa|psp | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O14715 | RGPD8 | S1231 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15126 | SCAMP1 | S41 | ochoa | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15156 | ZBTB7B | S475 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15173 | PGRMC2 | S90 | ochoa | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}. |
| O43182 | ARHGAP6 | S927 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43304 | SEC14L5 | S202 | ochoa | SEC14-like protein 5 | None |
| O60244 | MED14 | S1112 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60264 | SMARCA5 | S47 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60271 | SPAG9 | S279 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75376 | NCOR1 | S1164 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S2394 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75533 | SF3B1 | S336 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75925 | PIAS1 | S506 | ochoa | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O76021 | RSL1D1 | S413 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O94826 | TOMM70 | S96 | ochoa | Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). {ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:32728199, ECO:0000269|PubMed:35025629}. |
| P00519 | ABL1 | S828 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P00533 | EGFR | S1130 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04626 | ERBB2 | S1235 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P06396 | GSN | S51 | ochoa | Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:19666512, ECO:0000269|PubMed:20393563}. |
| P08069 | IGF1R | S1339 | ochoa | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P0DJD0 | RGPD1 | S1216 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1224 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P11274 | BCR | S93 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P11274 | BCR | S95 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P12270 | TPR | S648 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12931 | SRC | S35 | ochoa|psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P15336 | ATF2 | S328 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P16144 | ITGB4 | S1432 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17677 | GAP43 | S154 | ochoa | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}. |
| P26378 | ELAVL4 | S228 | ochoa | ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) | RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:7898713). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:Q61701, ECO:0000269|PubMed:10710437, ECO:0000269|PubMed:12034726, ECO:0000269|PubMed:12468554, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:17234598, ECO:0000269|PubMed:18218628, ECO:0000269|PubMed:24857657, ECO:0000269|PubMed:7898713}. |
| P31939 | ATIC | S264 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P35568 | IRS1 | S449 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P36871 | PGM1 | S117 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P48634 | PRRC2A | S119 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S932 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49792 | RANBP2 | S2207 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51610 | HCFC1 | S507 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P51825 | AFF1 | S871 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52948 | NUP98 | S656 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54725 | RAD23A | S99 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P56524 | HDAC4 | S628 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P58012 | FOXL2 | T329 | psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| P68104 | EEF1A1 | S414 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P78559 | MAP1A | S500 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82987 | ADAMTSL3 | S631 | ochoa | ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) | None |
| P98082 | DAB2 | S367 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01970 | PLCB3 | S929 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q02641 | CACNB1 | S416 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q05682 | CALD1 | S691 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q08050 | FOXM1 | S623 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q12802 | AKAP13 | S1618 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12852 | MAP3K12 | S652 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q12968 | NFATC3 | S261 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13233 | MAP3K1 | S34 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13233 | MAP3K1 | S133 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13625 | TP53BP2 | S572 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14126 | DSG2 | S972 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14676 | MDC1 | S1570 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14814 | MEF2D | S242 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14847 | LASP1 | S194 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q15124 | PGM5 | S122 | ochoa | Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) | Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). {ECO:0000269|PubMed:8175905}. |
| Q15717 | ELAVL1 | S197 | ochoa | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q15742 | NAB2 | S205 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q16555 | DPYSL2 | S517 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q16625 | OCLN | S340 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q16825 | PTPN21 | S480 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q2M2I8 | AAK1 | S642 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q2T9J0 | TYSND1 | S112 | ochoa | Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form] | Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids. {ECO:0000269|PubMed:22002062}. |
| Q2TAZ0 | ATG2A | S1327 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q52LW3 | ARHGAP29 | S1185 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5BKZ1 | ZNF326 | S137 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5JSZ5 | PRRC2B | S563 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SYE7 | NHSL1 | S1493 | ochoa | NHS-like protein 1 | None |
| Q5T0Z8 | C6orf132 | S722 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5TGY3 | AHDC1 | S1472 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5U5Q3 | MEX3C | S152 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q5VTE0 | EEF1A1P5 | S414 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q5XKK7 | FAM219B | S35 | ochoa | Protein FAM219B | None |
| Q63ZY3 | KANK2 | S171 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q66K74 | MAP1S | S595 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q66K74 | MAP1S | S603 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68DK7 | MSL1 | S392 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6IA17 | SIGIRR | S346 | ochoa | Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8) | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876, ECO:0000269|PubMed:25963006}. |
| Q6IBW4 | NCAPH2 | S308 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6P1J9 | CDC73 | S345 | ochoa | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6P1N0 | CC2D1A | S203 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6UUV7 | CRTC3 | S169 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6ZRS2 | SRCAP | S2883 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZU35 | CRACD | S878 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZUT6 | CCDC9B | S387 | ochoa | Coiled-coil domain-containing protein 9B | None |
| Q6ZV73 | FGD6 | S44 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q765P7 | MTSS2 | S538 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7L7X3 | TAOK1 | S172 | ochoa | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z2K8 | GPRIN1 | S381 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2K8 | GPRIN1 | S507 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3J3 | RGPD4 | S1232 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3K3 | POGZ | S703 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z5L9 | IRF2BP2 | S409 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q86UW6 | N4BP2 | S1216 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q86X27 | RALGPS2 | S311 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86YV0 | RASAL3 | S377 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8N441 | FGFRL1 | S141 | ochoa | Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5) | Has a negative effect on cell proliferation. {ECO:0000250}. |
| Q8N4L2 | PIP4P2 | Y28 | ochoa | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). {ECO:0000250|UniProtKB:Q9CZX7, ECO:0000269|PubMed:16365287}. |
| Q8N5H7 | SH2D3C | S411 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8NEY1 | NAV1 | S1377 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NI35 | PATJ | S333 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TEM1 | NUP210 | Y1855 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8WUF5 | PPP1R13L | S489 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WUI4 | HDAC7 | S482 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WUI4 | HDAC7 | S493 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WVT3 | TRAPPC12 | S171 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q8WWY3 | PRPF31 | S450 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q92547 | TOPBP1 | S1216 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92734 | TFG | S193 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q92793 | CREBBP | S281 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92934 | BAD | S71 | ochoa | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q92945 | KHSRP | S670 | ochoa|psp | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q92966 | SNAPC3 | S69 | ochoa | snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}. |
| Q92993 | KAT5 | S90 | ochoa|psp | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}. |
| Q96BD5 | PHF21A | S450 | ochoa | PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269|PubMed:16140033}. |
| Q96BF3 | TMIGD2 | S193 | ochoa | Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1) | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
| Q96ER9 | CCDC51 | S284 | ochoa | Mitochondrial potassium channel (MITOK) (Coiled-coil domain-containing protein 51) | Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume (PubMed:31435016). {ECO:0000269|PubMed:31435016}. |
| Q96F05 | C11orf24 | S278 | ochoa | Uncharacterized protein C11orf24 (Protein DM4E3) | None |
| Q96G42 | KLHDC7B | S142 | ochoa | Kelch domain-containing protein 7B | None |
| Q96HP0 | DOCK6 | S1230 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96NA2 | RILP | S377 | ochoa | Rab-interacting lysosomal protein | Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11179213, PubMed:11696325, PubMed:12944476, PubMed:14668488, PubMed:27113757). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:27113757}. |
| Q96Q45 | TMEM237 | S47 | ochoa | Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein) | Component of the transition zone in primary cilia. Required for ciliogenesis. {ECO:0000269|PubMed:22152675}. |
| Q96R06 | SPAG5 | S954 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RK0 | CIC | S1294 | ochoa | Protein capicua homolog | Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}. |
| Q96TA1 | NIBAN2 | S641 | ochoa|psp | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99611 | SEPHS2 | S97 | ochoa | Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) | Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}. |
| Q99666 | RGPD5 | S1231 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99684 | GFI1 | S101 | ochoa | Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163) | Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020). {ECO:0000250|UniProtKB:P70338, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12778173, ECO:0000269|PubMed:16287849, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:19026687, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:29651020, ECO:0000269|PubMed:8754800}. |
| Q99700 | ATXN2 | S736 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BR39 | JPH2 | S182 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BR76 | CORO1B | S423 | ochoa | Coronin-1B (Coronin-2) | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}. |
| Q9BWG6 | SCNM1 | S173 | ochoa | Sodium channel modifier 1 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}. |
| Q9BY89 | KIAA1671 | S1007 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9GZY8 | MFF | S74 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H0X9 | OSBPL5 | S67 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H1K0 | RBSN | S583 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H2D6 | TRIOBP | S1995 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2K8 | TAOK3 | S168 | ochoa | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
| Q9H3T3 | SEMA6B | S812 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H910 | JPT2 | S144 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HDC5 | JPH1 | S533 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NPD3 | EXOSC4 | S61 | ochoa | Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}. |
| Q9NQX7 | ITM2C | S22 | ochoa | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}. |
| Q9NR12 | PDLIM7 | S29 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NR12 | PDLIM7 | S203 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRR5 | UBQLN4 | S106 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9NU19 | TBC1D22B | S116 | ochoa | TBC1 domain family member 22B | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q9NW82 | WDR70 | S616 | ochoa | WD repeat-containing protein 70 | None |
| Q9NZM4 | BICRA | S752 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
| Q9P219 | CCDC88C | S1444 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9UBY9 | HSPB7 | S60 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
| Q9UJY4 | GGA2 | S334 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9UKV3 | ACIN1 | S522 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UQ35 | SRRM2 | S2335 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2T7 | YBX2 | S74 | ochoa | Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog) | Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250|UniProtKB:Q9Z2C8}. |
| Q9Y4B5 | MTCL1 | S1536 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F5 | CEP170B | S483 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F5 | CEP170B | S1551 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4H2 | IRS2 | S523 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6I3 | EPN1 | S442 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| P07814 | EPRS1 | S1122 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P49750 | YLPM1 | S1088 | PSP | YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113) | Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. {ECO:0000250}. |
| P00540 | MOS | S25 | Sugiyama | Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos) | Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation. {ECO:0000269|PubMed:34779126, ECO:0000269|PubMed:34997960, ECO:0000269|PubMed:35670744}. |
| P35568 | IRS1 | S315 | SIGNOR | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| Q9H6Y2 | WDR55 | S42 | Sugiyama | WD repeat-containing protein 55 | Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}. |
| Q9NQU5 | PAK6 | S146 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000005 | 5.315 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000006 | 5.248 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000006 | 5.248 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000008 | 5.119 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000008 | 5.119 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000009 | 5.057 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000009 | 5.057 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000010 | 4.997 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000012 | 4.939 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000022 | 4.656 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000019 | 4.718 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000022 | 4.666 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000015 | 4.826 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000022 | 4.666 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.000022 | 4.666 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000017 | 4.771 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000019 | 4.718 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.000024 | 4.616 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.000042 | 4.378 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.000046 | 4.334 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000062 | 4.210 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.000118 | 3.928 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000127 | 3.896 |
| R-HSA-191859 | snRNP Assembly | 0.000150 | 3.825 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.000150 | 3.825 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.000175 | 3.757 |
| R-HSA-9707616 | Heme signaling | 0.000189 | 3.724 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.000189 | 3.724 |
| R-HSA-3371556 | Cellular response to heat stress | 0.000206 | 3.686 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000223 | 3.651 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.000383 | 3.417 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000409 | 3.389 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.000390 | 3.409 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.000464 | 3.333 |
| R-HSA-525793 | Myogenesis | 0.000576 | 3.240 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.000589 | 3.230 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000706 | 3.151 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.000666 | 3.176 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.000682 | 3.166 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.000629 | 3.201 |
| R-HSA-166520 | Signaling by NTRKs | 0.000797 | 3.099 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.000802 | 3.096 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000830 | 3.081 |
| R-HSA-9609690 | HCMV Early Events | 0.001020 | 2.991 |
| R-HSA-68875 | Mitotic Prophase | 0.001066 | 2.972 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.001085 | 2.964 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.001284 | 2.891 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.001284 | 2.891 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.001284 | 2.891 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.001284 | 2.891 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.001284 | 2.891 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.001541 | 2.812 |
| R-HSA-70171 | Glycolysis | 0.002036 | 2.691 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.002224 | 2.653 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.002306 | 2.637 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.002866 | 2.543 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.002866 | 2.543 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.002669 | 2.574 |
| R-HSA-211000 | Gene Silencing by RNA | 0.002866 | 2.543 |
| R-HSA-74713 | IRS activation | 0.003115 | 2.507 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.003186 | 2.497 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.004038 | 2.394 |
| R-HSA-75153 | Apoptotic execution phase | 0.003836 | 2.416 |
| R-HSA-9609646 | HCMV Infection | 0.004626 | 2.335 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.004358 | 2.361 |
| R-HSA-9610379 | HCMV Late Events | 0.004661 | 2.332 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.004556 | 2.341 |
| R-HSA-74160 | Gene expression (Transcription) | 0.004582 | 2.339 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.004724 | 2.326 |
| R-HSA-70326 | Glucose metabolism | 0.004556 | 2.341 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.005633 | 2.249 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.005829 | 2.234 |
| R-HSA-112412 | SOS-mediated signalling | 0.006214 | 2.207 |
| R-HSA-177929 | Signaling by EGFR | 0.006923 | 2.160 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.006214 | 2.207 |
| R-HSA-72306 | tRNA processing | 0.006988 | 2.156 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.007345 | 2.134 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.007463 | 2.127 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.007710 | 2.113 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.008097 | 2.092 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.010945 | 1.961 |
| R-HSA-198203 | PI3K/AKT activation | 0.010266 | 1.989 |
| R-HSA-74749 | Signal attenuation | 0.010266 | 1.989 |
| R-HSA-3214847 | HATs acetylate histones | 0.009660 | 2.015 |
| R-HSA-2586552 | Signaling by Leptin | 0.010266 | 1.989 |
| R-HSA-1640170 | Cell Cycle | 0.011453 | 1.941 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.011520 | 1.939 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.011844 | 1.927 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.011956 | 1.922 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.013621 | 1.866 |
| R-HSA-4839726 | Chromatin organization | 0.013991 | 1.854 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.014187 | 1.848 |
| R-HSA-8853659 | RET signaling | 0.014187 | 1.848 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.014670 | 1.834 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.014670 | 1.834 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.016713 | 1.777 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.017034 | 1.769 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.016304 | 1.788 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.015894 | 1.799 |
| R-HSA-162587 | HIV Life Cycle | 0.017145 | 1.766 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.018581 | 1.731 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.018953 | 1.722 |
| R-HSA-109581 | Apoptosis | 0.019379 | 1.713 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.020959 | 1.679 |
| R-HSA-5619102 | SLC transporter disorders | 0.021803 | 1.661 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.023049 | 1.637 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.024720 | 1.607 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.024720 | 1.607 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.025222 | 1.598 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.027474 | 1.561 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.029804 | 1.526 |
| R-HSA-180292 | GAB1 signalosome | 0.029804 | 1.526 |
| R-HSA-168255 | Influenza Infection | 0.029045 | 1.537 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.026526 | 1.576 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.029460 | 1.531 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.029878 | 1.525 |
| R-HSA-9909396 | Circadian clock | 0.030133 | 1.521 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 0.034241 | 1.465 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.045394 | 1.343 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.045394 | 1.343 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.045394 | 1.343 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.045394 | 1.343 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.045394 | 1.343 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.045394 | 1.343 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.045394 | 1.343 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.045394 | 1.343 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.045394 | 1.343 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.045394 | 1.343 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.045394 | 1.343 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.042550 | 1.371 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.041425 | 1.383 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.042373 | 1.373 |
| R-HSA-8953854 | Metabolism of RNA | 0.042130 | 1.375 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.039861 | 1.399 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.039280 | 1.406 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.044864 | 1.348 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.042383 | 1.373 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.045304 | 1.344 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.045585 | 1.341 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.046094 | 1.336 |
| R-HSA-68886 | M Phase | 0.046969 | 1.328 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.047236 | 1.326 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.048123 | 1.318 |
| R-HSA-5357801 | Programmed Cell Death | 0.048741 | 1.312 |
| R-HSA-9675108 | Nervous system development | 0.050040 | 1.301 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.050423 | 1.297 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.051004 | 1.292 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.051450 | 1.289 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.067317 | 1.172 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.067317 | 1.172 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.063113 | 1.200 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.063113 | 1.200 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.066279 | 1.179 |
| R-HSA-182971 | EGFR downregulation | 0.069496 | 1.158 |
| R-HSA-191650 | Regulation of gap junction activity | 0.067317 | 1.172 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.060379 | 1.219 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.066279 | 1.179 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.054125 | 1.267 |
| R-HSA-5693538 | Homology Directed Repair | 0.069053 | 1.161 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.052360 | 1.281 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.066279 | 1.179 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.066279 | 1.179 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.067264 | 1.172 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.056419 | 1.249 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.066279 | 1.179 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.067317 | 1.172 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.056945 | 1.245 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.053624 | 1.271 |
| R-HSA-422475 | Axon guidance | 0.067436 | 1.171 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.060002 | 1.222 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.069496 | 1.158 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.060002 | 1.222 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.063806 | 1.195 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.053945 | 1.268 |
| R-HSA-212436 | Generic Transcription Pathway | 0.067033 | 1.174 |
| R-HSA-373760 | L1CAM interactions | 0.066094 | 1.180 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.058677 | 1.232 |
| R-HSA-162906 | HIV Infection | 0.069716 | 1.157 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.071262 | 1.147 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.071262 | 1.147 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.073619 | 1.133 |
| R-HSA-9679506 | SARS-CoV Infections | 0.074215 | 1.130 |
| R-HSA-354192 | Integrin signaling | 0.076080 | 1.119 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.078089 | 1.107 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.088738 | 1.052 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.088738 | 1.052 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.088738 | 1.052 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.088738 | 1.052 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.099265 | 1.003 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.099265 | 1.003 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.109670 | 0.960 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.119956 | 0.921 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.119956 | 0.921 |
| R-HSA-196025 | Formation of annular gap junctions | 0.119956 | 0.921 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.130124 | 0.886 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.130124 | 0.886 |
| R-HSA-190873 | Gap junction degradation | 0.130124 | 0.886 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.140175 | 0.853 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.150111 | 0.824 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.150111 | 0.824 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.159932 | 0.796 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.169640 | 0.770 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.169640 | 0.770 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.179237 | 0.747 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.198101 | 0.703 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.198101 | 0.703 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.198101 | 0.703 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.207370 | 0.683 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.225591 | 0.647 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.158528 | 0.800 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.225591 | 0.647 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.225591 | 0.647 |
| R-HSA-72172 | mRNA Splicing | 0.121362 | 0.916 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.081560 | 1.089 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.081560 | 1.089 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.179237 | 0.747 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.103971 | 0.983 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.086062 | 1.065 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.081560 | 1.089 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.216533 | 0.664 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.169640 | 0.770 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.126812 | 0.897 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.129307 | 0.888 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.130124 | 0.886 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.169640 | 0.770 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.198101 | 0.703 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.216533 | 0.664 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.115355 | 0.938 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.119197 | 0.924 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.169640 | 0.770 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.188723 | 0.724 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.104187 | 0.982 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.166675 | 0.778 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.159932 | 0.796 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.082853 | 1.082 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.216798 | 0.664 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.140175 | 0.853 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.159932 | 0.796 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.082853 | 1.082 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.169640 | 0.770 |
| R-HSA-112399 | IRS-mediated signalling | 0.174894 | 0.757 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.119956 | 0.921 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.109670 | 0.960 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.119956 | 0.921 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.130124 | 0.886 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.150111 | 0.824 |
| R-HSA-171007 | p38MAPK events | 0.198101 | 0.703 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.096918 | 1.014 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.204111 | 0.690 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.188723 | 0.724 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.106677 | 0.972 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.159932 | 0.796 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.159932 | 0.796 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.188723 | 0.724 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.207370 | 0.683 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.138523 | 0.858 |
| R-HSA-9842663 | Signaling by LTK | 0.169640 | 0.770 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.142479 | 0.846 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.099265 | 1.003 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.188723 | 0.724 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.086307 | 1.064 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.216533 | 0.664 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.170776 | 0.768 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.216533 | 0.664 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.078089 | 1.107 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.109670 | 0.960 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.130124 | 0.886 |
| R-HSA-428540 | Activation of RAC1 | 0.159932 | 0.796 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.169640 | 0.770 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.169640 | 0.770 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.169640 | 0.770 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.198101 | 0.703 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.207370 | 0.683 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.162957 | 0.788 |
| R-HSA-73894 | DNA Repair | 0.155576 | 0.808 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.142468 | 0.846 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.130124 | 0.886 |
| R-HSA-8876725 | Protein methylation | 0.198101 | 0.703 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.131903 | 0.880 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.124171 | 0.906 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.104187 | 0.982 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.078089 | 1.107 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.088738 | 1.052 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.119956 | 0.921 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.130124 | 0.886 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.169640 | 0.770 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.169640 | 0.770 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.169640 | 0.770 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.183175 | 0.737 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.187338 | 0.727 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.077141 | 1.113 |
| R-HSA-5689877 | Josephin domain DUBs | 0.140175 | 0.853 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.198101 | 0.703 |
| R-HSA-70370 | Galactose catabolism | 0.216533 | 0.664 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.216533 | 0.664 |
| R-HSA-109704 | PI3K Cascade | 0.146458 | 0.834 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.152394 | 0.817 |
| R-HSA-2262752 | Cellular responses to stress | 0.153099 | 0.815 |
| R-HSA-9659379 | Sensory processing of sound | 0.081708 | 1.088 |
| R-HSA-8848021 | Signaling by PTK6 | 0.199901 | 0.699 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.199901 | 0.699 |
| R-HSA-9675135 | Diseases of DNA repair | 0.130689 | 0.884 |
| R-HSA-373755 | Semaphorin interactions | 0.199901 | 0.699 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.163720 | 0.786 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.119956 | 0.921 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.140175 | 0.853 |
| R-HSA-210990 | PECAM1 interactions | 0.150111 | 0.824 |
| R-HSA-437239 | Recycling pathway of L1 | 0.134593 | 0.871 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.170776 | 0.768 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.221043 | 0.656 |
| R-HSA-162582 | Signal Transduction | 0.220052 | 0.657 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.133312 | 0.875 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.166675 | 0.778 |
| R-HSA-157118 | Signaling by NOTCH | 0.084228 | 1.075 |
| R-HSA-8939211 | ESR-mediated signaling | 0.080741 | 1.093 |
| R-HSA-1266738 | Developmental Biology | 0.106197 | 0.974 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.169640 | 0.770 |
| R-HSA-5635838 | Activation of SMO | 0.207370 | 0.683 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.130124 | 0.886 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.188723 | 0.724 |
| R-HSA-201556 | Signaling by ALK | 0.100534 | 0.998 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.159938 | 0.796 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.198101 | 0.703 |
| R-HSA-381042 | PERK regulates gene expression | 0.086307 | 1.064 |
| R-HSA-5205647 | Mitophagy | 0.082853 | 1.082 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.195702 | 0.708 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.195702 | 0.708 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.209166 | 0.680 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.205102 | 0.688 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.159854 | 0.796 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.170776 | 0.768 |
| R-HSA-69236 | G1 Phase | 0.122963 | 0.910 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.122963 | 0.910 |
| R-HSA-195721 | Signaling by WNT | 0.167022 | 0.777 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.216533 | 0.664 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.201919 | 0.695 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.201919 | 0.695 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.210853 | 0.676 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.210853 | 0.676 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.201919 | 0.695 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.187240 | 0.728 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.105915 | 0.975 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.111672 | 0.952 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.154206 | 0.812 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.228616 | 0.641 |
| R-HSA-913531 | Interferon Signaling | 0.191967 | 0.717 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.092687 | 1.033 |
| R-HSA-69481 | G2/M Checkpoints | 0.228972 | 0.640 |
| R-HSA-68877 | Mitotic Prometaphase | 0.233549 | 0.632 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.233776 | 0.631 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.233817 | 0.631 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.233817 | 0.631 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.233817 | 0.631 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.234544 | 0.630 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.234544 | 0.630 |
| R-HSA-3928664 | Ephrin signaling | 0.234544 | 0.630 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.234544 | 0.630 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.234544 | 0.630 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.234544 | 0.630 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.234544 | 0.630 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.242358 | 0.616 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.243395 | 0.614 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.243395 | 0.614 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.243395 | 0.614 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.243395 | 0.614 |
| R-HSA-9843745 | Adipogenesis | 0.244287 | 0.612 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.250913 | 0.600 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.252144 | 0.598 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.252144 | 0.598 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.252144 | 0.598 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.252144 | 0.598 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.252144 | 0.598 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.252144 | 0.598 |
| R-HSA-445144 | Signal transduction by L1 | 0.252144 | 0.598 |
| R-HSA-3322077 | Glycogen synthesis | 0.252144 | 0.598 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.255599 | 0.592 |
| R-HSA-9824446 | Viral Infection Pathways | 0.260575 | 0.584 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.260792 | 0.584 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.260792 | 0.584 |
| R-HSA-167044 | Signalling to RAS | 0.260792 | 0.584 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.260792 | 0.584 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.260792 | 0.584 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.262874 | 0.580 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.269340 | 0.570 |
| R-HSA-977225 | Amyloid fiber formation | 0.276609 | 0.558 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.277790 | 0.556 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.277790 | 0.556 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.277790 | 0.556 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.277790 | 0.556 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.277790 | 0.556 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.277790 | 0.556 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.285169 | 0.545 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.286143 | 0.543 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.286143 | 0.543 |
| R-HSA-3000170 | Syndecan interactions | 0.286143 | 0.543 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.286143 | 0.543 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.289446 | 0.538 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.294400 | 0.531 |
| R-HSA-429947 | Deadenylation of mRNA | 0.294400 | 0.531 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.294400 | 0.531 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.294400 | 0.531 |
| R-HSA-68882 | Mitotic Anaphase | 0.294450 | 0.531 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.297039 | 0.527 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.302257 | 0.520 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.302562 | 0.519 |
| R-HSA-420029 | Tight junction interactions | 0.302562 | 0.519 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.302562 | 0.519 |
| R-HSA-9620244 | Long-term potentiation | 0.302562 | 0.519 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.302562 | 0.519 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.302562 | 0.519 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.302562 | 0.519 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.302562 | 0.519 |
| R-HSA-3000157 | Laminin interactions | 0.302562 | 0.519 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.302562 | 0.519 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.303663 | 0.518 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.310630 | 0.508 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.310630 | 0.508 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.310630 | 0.508 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.310630 | 0.508 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.310630 | 0.508 |
| R-HSA-9663891 | Selective autophagy | 0.310777 | 0.508 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.317179 | 0.499 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.318605 | 0.497 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.318605 | 0.497 |
| R-HSA-1989781 | PPARA activates gene expression | 0.325771 | 0.487 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.326489 | 0.486 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.326489 | 0.486 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.326489 | 0.486 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.326489 | 0.486 |
| R-HSA-9612973 | Autophagy | 0.328932 | 0.483 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.331975 | 0.479 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.331975 | 0.479 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.332092 | 0.479 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.334281 | 0.476 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.334281 | 0.476 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.334281 | 0.476 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.341984 | 0.466 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.341984 | 0.466 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.341984 | 0.466 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.341984 | 0.466 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.349599 | 0.456 |
| R-HSA-186763 | Downstream signal transduction | 0.349599 | 0.456 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.352988 | 0.452 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.357125 | 0.447 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.361331 | 0.442 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.361331 | 0.442 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.361331 | 0.442 |
| R-HSA-190236 | Signaling by FGFR | 0.361331 | 0.442 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.364566 | 0.438 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.364566 | 0.438 |
| R-HSA-9930044 | Nuclear RNA decay | 0.364566 | 0.438 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.364566 | 0.438 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.364566 | 0.438 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.364566 | 0.438 |
| R-HSA-9733709 | Cardiogenesis | 0.364566 | 0.438 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.364566 | 0.438 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.364566 | 0.438 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.364566 | 0.438 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.364566 | 0.438 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.365488 | 0.437 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.371920 | 0.430 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.371920 | 0.430 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.371920 | 0.430 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.371920 | 0.430 |
| R-HSA-199991 | Membrane Trafficking | 0.374523 | 0.427 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.379190 | 0.421 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.379190 | 0.421 |
| R-HSA-5673000 | RAF activation | 0.379190 | 0.421 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.379190 | 0.421 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.379190 | 0.421 |
| R-HSA-392518 | Signal amplification | 0.379190 | 0.421 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.379190 | 0.421 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.379334 | 0.421 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.386376 | 0.413 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.386376 | 0.413 |
| R-HSA-187687 | Signalling to ERKs | 0.386376 | 0.413 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.390201 | 0.409 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.390201 | 0.409 |
| R-HSA-9833110 | RSV-host interactions | 0.390201 | 0.409 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.393479 | 0.405 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.393479 | 0.405 |
| R-HSA-3371511 | HSF1 activation | 0.393479 | 0.405 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.394280 | 0.404 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.398346 | 0.400 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.400500 | 0.397 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.400500 | 0.397 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.400500 | 0.397 |
| R-HSA-419037 | NCAM1 interactions | 0.400500 | 0.397 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.406440 | 0.391 |
| R-HSA-8875878 | MET promotes cell motility | 0.407441 | 0.390 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.410467 | 0.387 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.414302 | 0.383 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.421083 | 0.376 |
| R-HSA-3371568 | Attenuation phase | 0.421083 | 0.376 |
| R-HSA-8982491 | Glycogen metabolism | 0.421083 | 0.376 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.426442 | 0.370 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.427787 | 0.369 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.427787 | 0.369 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.430401 | 0.366 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.434413 | 0.362 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.434413 | 0.362 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.434413 | 0.362 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.440963 | 0.356 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.447438 | 0.349 |
| R-HSA-8854214 | TBC/RABGAPs | 0.447438 | 0.349 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.447438 | 0.349 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.449975 | 0.347 |
| R-HSA-373752 | Netrin-1 signaling | 0.453838 | 0.343 |
| R-HSA-190828 | Gap junction trafficking | 0.453838 | 0.343 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.453838 | 0.343 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.460164 | 0.337 |
| R-HSA-774815 | Nucleosome assembly | 0.460164 | 0.337 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.460164 | 0.337 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.460164 | 0.337 |
| R-HSA-1643685 | Disease | 0.464564 | 0.333 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.466418 | 0.331 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.466418 | 0.331 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.466418 | 0.331 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.466418 | 0.331 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.466418 | 0.331 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.466418 | 0.331 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.472599 | 0.326 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.472957 | 0.325 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.472957 | 0.325 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.477053 | 0.321 |
| R-HSA-9634597 | GPER1 signaling | 0.478709 | 0.320 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.478709 | 0.320 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.478709 | 0.320 |
| R-HSA-9766229 | Degradation of CDH1 | 0.484749 | 0.314 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.490719 | 0.309 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.496620 | 0.304 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.502453 | 0.299 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.502453 | 0.299 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.502453 | 0.299 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.502453 | 0.299 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.508219 | 0.294 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.508219 | 0.294 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.508219 | 0.294 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.525122 | 0.280 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.530626 | 0.275 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.530626 | 0.275 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.531324 | 0.275 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.536067 | 0.271 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.538307 | 0.269 |
| R-HSA-9033241 | Peroxisomal protein import | 0.541446 | 0.266 |
| R-HSA-186712 | Regulation of beta-cell development | 0.541446 | 0.266 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.541446 | 0.266 |
| R-HSA-6807070 | PTEN Regulation | 0.541771 | 0.266 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.541771 | 0.266 |
| R-HSA-9664407 | Parasite infection | 0.545218 | 0.263 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.545218 | 0.263 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.545218 | 0.263 |
| R-HSA-379724 | tRNA Aminoacylation | 0.546762 | 0.262 |
| R-HSA-983189 | Kinesins | 0.546762 | 0.262 |
| R-HSA-1632852 | Macroautophagy | 0.548647 | 0.261 |
| R-HSA-1500931 | Cell-Cell communication | 0.549033 | 0.260 |
| R-HSA-112043 | PLC beta mediated events | 0.552017 | 0.258 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.552017 | 0.258 |
| R-HSA-450294 | MAP kinase activation | 0.552017 | 0.258 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.557212 | 0.254 |
| R-HSA-1268020 | Mitochondrial protein import | 0.557212 | 0.254 |
| R-HSA-186797 | Signaling by PDGF | 0.557212 | 0.254 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.562347 | 0.250 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.568838 | 0.245 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.572439 | 0.242 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.572439 | 0.242 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.577398 | 0.239 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.577398 | 0.239 |
| R-HSA-9758941 | Gastrulation | 0.578689 | 0.238 |
| R-HSA-112040 | G-protein mediated events | 0.582299 | 0.235 |
| R-HSA-597592 | Post-translational protein modification | 0.583645 | 0.234 |
| R-HSA-9609507 | Protein localization | 0.591566 | 0.228 |
| R-HSA-73887 | Death Receptor Signaling | 0.594739 | 0.226 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.596668 | 0.224 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.596668 | 0.224 |
| R-HSA-448424 | Interleukin-17 signaling | 0.596668 | 0.224 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.596668 | 0.224 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.601347 | 0.221 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.601347 | 0.221 |
| R-HSA-4086398 | Ca2+ pathway | 0.610545 | 0.214 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.615064 | 0.211 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.615064 | 0.211 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.615064 | 0.211 |
| R-HSA-5663205 | Infectious disease | 0.617624 | 0.209 |
| R-HSA-8852135 | Protein ubiquitination | 0.619531 | 0.208 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.619531 | 0.208 |
| R-HSA-5688426 | Deubiquitination | 0.620890 | 0.207 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.623829 | 0.205 |
| R-HSA-5689603 | UCH proteinases | 0.623946 | 0.205 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.625465 | 0.204 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.628311 | 0.202 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.628863 | 0.201 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.632625 | 0.199 |
| R-HSA-4086400 | PCP/CE pathway | 0.632625 | 0.199 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.632625 | 0.199 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.636889 | 0.196 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.641104 | 0.193 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.641104 | 0.193 |
| R-HSA-6806834 | Signaling by MET | 0.641104 | 0.193 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.641104 | 0.193 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.657157 | 0.182 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.657484 | 0.182 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.659930 | 0.181 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.661461 | 0.179 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.665392 | 0.177 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.669278 | 0.174 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.673119 | 0.172 |
| R-HSA-446728 | Cell junction organization | 0.674369 | 0.171 |
| R-HSA-156902 | Peptide chain elongation | 0.676916 | 0.169 |
| R-HSA-3781865 | Diseases of glycosylation | 0.684086 | 0.165 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.688045 | 0.162 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.695251 | 0.158 |
| R-HSA-2029481 | FCGR activation | 0.698792 | 0.156 |
| R-HSA-1474290 | Collagen formation | 0.702292 | 0.153 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.712551 | 0.147 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.715892 | 0.145 |
| R-HSA-422356 | Regulation of insulin secretion | 0.719194 | 0.143 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.722458 | 0.141 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.728874 | 0.137 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.730485 | 0.136 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.732026 | 0.135 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.738222 | 0.132 |
| R-HSA-111885 | Opioid Signalling | 0.738222 | 0.132 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.738222 | 0.132 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.744275 | 0.128 |
| R-HSA-397014 | Muscle contraction | 0.752513 | 0.123 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.752513 | 0.123 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.754628 | 0.122 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.758805 | 0.120 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.758805 | 0.120 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.762569 | 0.118 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.764384 | 0.117 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.767126 | 0.115 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.777778 | 0.109 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.777778 | 0.109 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.792853 | 0.101 |
| R-HSA-73886 | Chromosome Maintenance | 0.792853 | 0.101 |
| R-HSA-168249 | Innate Immune System | 0.796153 | 0.099 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.800005 | 0.097 |
| R-HSA-194138 | Signaling by VEGF | 0.804636 | 0.094 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.806912 | 0.093 |
| R-HSA-6798695 | Neutrophil degranulation | 0.808242 | 0.092 |
| R-HSA-5576891 | Cardiac conduction | 0.820021 | 0.086 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.822118 | 0.085 |
| R-HSA-421270 | Cell-cell junction organization | 0.824222 | 0.084 |
| R-HSA-109582 | Hemostasis | 0.830020 | 0.081 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.831934 | 0.080 |
| R-HSA-163685 | Integration of energy metabolism | 0.832244 | 0.080 |
| R-HSA-5173105 | O-linked glycosylation | 0.834199 | 0.079 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.841797 | 0.075 |
| R-HSA-416476 | G alpha (q) signalling events | 0.843643 | 0.074 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.849217 | 0.071 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.854268 | 0.068 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.857242 | 0.067 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.859309 | 0.066 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.860950 | 0.065 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.862573 | 0.064 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.866112 | 0.062 |
| R-HSA-9658195 | Leishmania infection | 0.866112 | 0.062 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.867337 | 0.062 |
| R-HSA-9711097 | Cellular response to starvation | 0.871919 | 0.060 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.871919 | 0.060 |
| R-HSA-877300 | Interferon gamma signaling | 0.873414 | 0.059 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.874892 | 0.058 |
| R-HSA-168256 | Immune System | 0.875774 | 0.058 |
| R-HSA-392499 | Metabolism of proteins | 0.880784 | 0.055 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.890057 | 0.051 |
| R-HSA-418555 | G alpha (s) signalling events | 0.891341 | 0.050 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.892611 | 0.049 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.893865 | 0.049 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.893865 | 0.049 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.893865 | 0.049 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.893865 | 0.049 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.893865 | 0.049 |
| R-HSA-72766 | Translation | 0.896443 | 0.047 |
| R-HSA-2559583 | Cellular Senescence | 0.902249 | 0.045 |
| R-HSA-69275 | G2/M Transition | 0.908909 | 0.041 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.911027 | 0.040 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.911027 | 0.040 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.919020 | 0.037 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.922745 | 0.035 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.922745 | 0.035 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.924543 | 0.034 |
| R-HSA-112316 | Neuronal System | 0.925143 | 0.034 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.925426 | 0.034 |
| R-HSA-6805567 | Keratinization | 0.928858 | 0.032 |
| R-HSA-418990 | Adherens junctions interactions | 0.938238 | 0.028 |
| R-HSA-449147 | Signaling by Interleukins | 0.944434 | 0.025 |
| R-HSA-72312 | rRNA processing | 0.947637 | 0.023 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.949784 | 0.022 |
| R-HSA-15869 | Metabolism of nucleotides | 0.950051 | 0.022 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.950637 | 0.022 |
| R-HSA-418594 | G alpha (i) signalling events | 0.960373 | 0.018 |
| R-HSA-5668914 | Diseases of metabolism | 0.967534 | 0.014 |
| R-HSA-1280218 | Adaptive Immune System | 0.967596 | 0.014 |
| R-HSA-1483257 | Phospholipid metabolism | 0.975134 | 0.011 |
| R-HSA-8957322 | Metabolism of steroids | 0.982369 | 0.008 |
| R-HSA-1474244 | Extracellular matrix organization | 0.983774 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 0.983934 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.992052 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 0.992301 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.994574 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995508 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 0.999965 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999986 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.830 | 0.241 | 1 | 0.821 |
HIPK4 |
0.827 | 0.355 | 1 | 0.820 |
CDKL5 |
0.827 | 0.395 | -3 | 0.789 |
COT |
0.826 | 0.125 | 2 | 0.848 |
ICK |
0.818 | 0.422 | -3 | 0.827 |
PIM3 |
0.818 | 0.129 | -3 | 0.820 |
CDC7 |
0.817 | 0.149 | 1 | 0.846 |
MAK |
0.816 | 0.500 | -2 | 0.923 |
DYRK2 |
0.816 | 0.239 | 1 | 0.749 |
CDKL1 |
0.816 | 0.288 | -3 | 0.796 |
MOS |
0.813 | 0.157 | 1 | 0.864 |
ERK5 |
0.813 | 0.220 | 1 | 0.861 |
KIS |
0.813 | 0.121 | 1 | 0.717 |
SRPK1 |
0.813 | 0.143 | -3 | 0.768 |
P38B |
0.812 | 0.324 | 1 | 0.688 |
HIPK2 |
0.812 | 0.257 | 1 | 0.668 |
SKMLCK |
0.812 | 0.145 | -2 | 0.630 |
NDR2 |
0.810 | 0.088 | -3 | 0.811 |
CDK19 |
0.809 | 0.264 | 1 | 0.642 |
CDK8 |
0.808 | 0.242 | 1 | 0.677 |
MTOR |
0.808 | 0.085 | 1 | 0.759 |
ATR |
0.807 | 0.143 | 1 | 0.829 |
GRK1 |
0.807 | 0.091 | -2 | 0.550 |
CLK2 |
0.807 | 0.164 | -3 | 0.750 |
RSK2 |
0.806 | 0.076 | -3 | 0.767 |
P38A |
0.806 | 0.319 | 1 | 0.749 |
PRPK |
0.805 | 0.056 | -1 | 0.763 |
PRKD1 |
0.803 | 0.085 | -3 | 0.805 |
CDK18 |
0.803 | 0.222 | 1 | 0.641 |
ERK1 |
0.803 | 0.258 | 1 | 0.672 |
DYRK4 |
0.803 | 0.199 | 1 | 0.671 |
IKKB |
0.802 | -0.082 | -2 | 0.492 |
CHAK2 |
0.802 | 0.117 | -1 | 0.697 |
NLK |
0.802 | 0.087 | 1 | 0.826 |
DYRK1A |
0.801 | 0.264 | 1 | 0.752 |
TBK1 |
0.801 | 0.065 | 1 | 0.676 |
GRK5 |
0.801 | 0.013 | -3 | 0.828 |
CDK1 |
0.801 | 0.177 | 1 | 0.675 |
AURC |
0.801 | 0.050 | -2 | 0.482 |
PIM1 |
0.800 | 0.074 | -3 | 0.777 |
P38D |
0.800 | 0.226 | 1 | 0.604 |
RAF1 |
0.799 | -0.025 | 1 | 0.797 |
CDK7 |
0.799 | 0.177 | 1 | 0.702 |
P90RSK |
0.799 | 0.057 | -3 | 0.773 |
JNK2 |
0.798 | 0.178 | 1 | 0.650 |
GRK7 |
0.798 | 0.111 | 1 | 0.753 |
CAMK1B |
0.798 | 0.001 | -3 | 0.829 |
HIPK1 |
0.796 | 0.187 | 1 | 0.754 |
BMPR1B |
0.796 | 0.085 | 1 | 0.817 |
P38G |
0.796 | 0.179 | 1 | 0.588 |
CDK5 |
0.796 | 0.184 | 1 | 0.721 |
IKKE |
0.795 | -0.024 | 1 | 0.671 |
FAM20C |
0.795 | 0.049 | 2 | 0.562 |
PRKD2 |
0.795 | 0.045 | -3 | 0.749 |
DSTYK |
0.794 | -0.082 | 2 | 0.856 |
CAMLCK |
0.794 | 0.033 | -2 | 0.606 |
NDR1 |
0.794 | 0.004 | -3 | 0.799 |
IKKA |
0.794 | -0.023 | -2 | 0.498 |
JNK3 |
0.794 | 0.145 | 1 | 0.682 |
WNK1 |
0.794 | 0.041 | -2 | 0.660 |
GRK6 |
0.794 | 0.013 | 1 | 0.813 |
PKACB |
0.794 | 0.056 | -2 | 0.478 |
PDHK4 |
0.794 | -0.117 | 1 | 0.812 |
GCN2 |
0.793 | -0.129 | 2 | 0.754 |
SRPK2 |
0.793 | 0.087 | -3 | 0.693 |
BMPR2 |
0.793 | -0.112 | -2 | 0.599 |
MARK4 |
0.793 | 0.006 | 4 | 0.774 |
CAMK2G |
0.793 | -0.067 | 2 | 0.747 |
NEK6 |
0.793 | -0.027 | -2 | 0.567 |
CDK13 |
0.792 | 0.108 | 1 | 0.676 |
PKACG |
0.792 | 0.007 | -2 | 0.534 |
MAPKAPK2 |
0.792 | 0.049 | -3 | 0.720 |
NUAK2 |
0.792 | 0.005 | -3 | 0.812 |
MLK2 |
0.792 | 0.146 | 2 | 0.785 |
CLK4 |
0.792 | 0.073 | -3 | 0.766 |
CDK3 |
0.792 | 0.169 | 1 | 0.614 |
RSK3 |
0.792 | 0.033 | -3 | 0.757 |
DAPK2 |
0.792 | 0.031 | -3 | 0.831 |
RIPK3 |
0.792 | 0.035 | 3 | 0.743 |
PAK1 |
0.791 | 0.054 | -2 | 0.598 |
MLK1 |
0.791 | 0.020 | 2 | 0.771 |
PKN3 |
0.790 | -0.005 | -3 | 0.789 |
GSK3A |
0.790 | 0.194 | 4 | 0.648 |
CAMK2D |
0.790 | -0.009 | -3 | 0.795 |
RSK4 |
0.790 | 0.069 | -3 | 0.739 |
MLK3 |
0.790 | 0.106 | 2 | 0.704 |
ULK2 |
0.789 | -0.117 | 2 | 0.741 |
NIK |
0.789 | -0.035 | -3 | 0.830 |
MAPKAPK3 |
0.789 | 0.017 | -3 | 0.750 |
HUNK |
0.788 | -0.051 | 2 | 0.813 |
PRKX |
0.788 | 0.059 | -3 | 0.679 |
SRPK3 |
0.788 | 0.069 | -3 | 0.740 |
CAMK2A |
0.788 | 0.041 | 2 | 0.746 |
GRK4 |
0.788 | -0.052 | -2 | 0.545 |
AMPKA1 |
0.787 | 0.007 | -3 | 0.811 |
HIPK3 |
0.787 | 0.181 | 1 | 0.747 |
MOK |
0.787 | 0.358 | 1 | 0.810 |
PKCD |
0.787 | 0.024 | 2 | 0.739 |
P70S6KB |
0.787 | 0.003 | -3 | 0.770 |
PKN2 |
0.786 | -0.021 | -3 | 0.798 |
CDK17 |
0.786 | 0.151 | 1 | 0.592 |
CDK12 |
0.786 | 0.108 | 1 | 0.650 |
ATM |
0.786 | 0.008 | 1 | 0.777 |
TGFBR2 |
0.786 | -0.093 | -2 | 0.506 |
MSK1 |
0.786 | 0.036 | -3 | 0.745 |
DYRK3 |
0.786 | 0.141 | 1 | 0.762 |
PDHK1 |
0.786 | -0.148 | 1 | 0.782 |
CLK1 |
0.786 | 0.074 | -3 | 0.737 |
LATS1 |
0.786 | 0.066 | -3 | 0.823 |
LATS2 |
0.786 | -0.013 | -5 | 0.681 |
MPSK1 |
0.785 | 0.338 | 1 | 0.780 |
MASTL |
0.785 | -0.092 | -2 | 0.575 |
TGFBR1 |
0.785 | 0.006 | -2 | 0.519 |
CAMK2B |
0.785 | 0.003 | 2 | 0.718 |
DYRK1B |
0.785 | 0.138 | 1 | 0.697 |
MSK2 |
0.784 | 0.005 | -3 | 0.755 |
AMPKA2 |
0.784 | 0.023 | -3 | 0.782 |
GSK3B |
0.784 | 0.148 | 4 | 0.640 |
NEK7 |
0.784 | -0.151 | -3 | 0.792 |
PAK3 |
0.784 | 0.008 | -2 | 0.574 |
CK1E |
0.784 | 0.086 | -3 | 0.650 |
PKCB |
0.784 | 0.046 | 2 | 0.707 |
IRE1 |
0.784 | 0.039 | 1 | 0.782 |
TSSK2 |
0.784 | -0.013 | -5 | 0.755 |
MNK2 |
0.783 | 0.011 | -2 | 0.565 |
MST4 |
0.783 | -0.054 | 2 | 0.776 |
DLK |
0.782 | -0.038 | 1 | 0.788 |
PAK6 |
0.782 | 0.051 | -2 | 0.511 |
ALK4 |
0.781 | -0.028 | -2 | 0.547 |
TSSK1 |
0.781 | 0.011 | -3 | 0.825 |
PKG2 |
0.781 | 0.015 | -2 | 0.492 |
NIM1 |
0.781 | -0.037 | 3 | 0.781 |
DNAPK |
0.781 | 0.052 | 1 | 0.702 |
PKCZ |
0.780 | 0.045 | 2 | 0.745 |
GRK2 |
0.780 | 0.002 | -2 | 0.489 |
NEK9 |
0.780 | -0.077 | 2 | 0.791 |
TLK2 |
0.780 | 0.009 | 1 | 0.774 |
AURB |
0.780 | -0.009 | -2 | 0.474 |
CDK9 |
0.780 | 0.072 | 1 | 0.679 |
PKCA |
0.779 | 0.041 | 2 | 0.685 |
SMG1 |
0.779 | 0.006 | 1 | 0.784 |
MLK4 |
0.779 | 0.048 | 2 | 0.690 |
AKT2 |
0.779 | 0.044 | -3 | 0.697 |
ERK2 |
0.779 | 0.128 | 1 | 0.706 |
BCKDK |
0.779 | -0.131 | -1 | 0.684 |
ULK1 |
0.779 | -0.138 | -3 | 0.752 |
CDK16 |
0.779 | 0.165 | 1 | 0.607 |
QSK |
0.779 | -0.006 | 4 | 0.733 |
SGK3 |
0.778 | 0.037 | -3 | 0.743 |
CDK14 |
0.778 | 0.134 | 1 | 0.677 |
PKCG |
0.778 | 0.018 | 2 | 0.703 |
PRP4 |
0.778 | 0.090 | -3 | 0.739 |
RIPK1 |
0.778 | -0.092 | 1 | 0.792 |
AURA |
0.777 | -0.012 | -2 | 0.448 |
MYLK4 |
0.777 | -0.011 | -2 | 0.532 |
PKACA |
0.776 | 0.033 | -2 | 0.444 |
PLK1 |
0.776 | -0.082 | -2 | 0.502 |
PASK |
0.776 | 0.100 | -3 | 0.840 |
TTBK2 |
0.776 | -0.080 | 2 | 0.694 |
PRKD3 |
0.776 | 0.004 | -3 | 0.741 |
MEK1 |
0.775 | -0.078 | 2 | 0.808 |
VRK2 |
0.775 | 0.019 | 1 | 0.837 |
JNK1 |
0.775 | 0.122 | 1 | 0.640 |
CDK2 |
0.775 | 0.057 | 1 | 0.740 |
WNK3 |
0.775 | -0.147 | 1 | 0.768 |
ACVR2B |
0.775 | -0.033 | -2 | 0.499 |
MNK1 |
0.775 | -0.017 | -2 | 0.563 |
PKR |
0.775 | -0.005 | 1 | 0.816 |
ACVR2A |
0.775 | -0.043 | -2 | 0.491 |
PAK2 |
0.774 | -0.023 | -2 | 0.578 |
PIM2 |
0.774 | 0.031 | -3 | 0.735 |
YSK4 |
0.774 | -0.067 | 1 | 0.722 |
GRK3 |
0.773 | 0.008 | -2 | 0.454 |
ALK2 |
0.773 | -0.041 | -2 | 0.520 |
CDK10 |
0.773 | 0.112 | 1 | 0.669 |
ANKRD3 |
0.772 | -0.184 | 1 | 0.820 |
MARK3 |
0.772 | -0.026 | 4 | 0.693 |
IRE2 |
0.772 | -0.000 | 2 | 0.688 |
DRAK1 |
0.772 | -0.016 | 1 | 0.790 |
BRSK1 |
0.771 | -0.026 | -3 | 0.763 |
CK1D |
0.771 | 0.048 | -3 | 0.606 |
BMPR1A |
0.771 | 0.007 | 1 | 0.781 |
CHAK1 |
0.770 | -0.027 | 2 | 0.749 |
CK1G1 |
0.770 | 0.036 | -3 | 0.647 |
DCAMKL1 |
0.770 | -0.001 | -3 | 0.763 |
CAMK4 |
0.770 | -0.119 | -3 | 0.777 |
QIK |
0.770 | -0.103 | -3 | 0.791 |
MELK |
0.770 | -0.054 | -3 | 0.763 |
SIK |
0.769 | -0.038 | -3 | 0.740 |
NUAK1 |
0.768 | -0.051 | -3 | 0.752 |
PKCH |
0.768 | -0.030 | 2 | 0.683 |
ERK7 |
0.768 | 0.083 | 2 | 0.530 |
PLK3 |
0.768 | -0.080 | 2 | 0.736 |
NEK2 |
0.767 | -0.082 | 2 | 0.773 |
MARK2 |
0.767 | -0.050 | 4 | 0.673 |
CK1A2 |
0.767 | 0.045 | -3 | 0.607 |
CK2A2 |
0.766 | 0.050 | 1 | 0.744 |
MST3 |
0.766 | 0.005 | 2 | 0.804 |
BRSK2 |
0.765 | -0.058 | -3 | 0.771 |
CHK1 |
0.765 | -0.068 | -3 | 0.759 |
PHKG1 |
0.764 | -0.066 | -3 | 0.792 |
MEKK2 |
0.764 | -0.039 | 2 | 0.765 |
PAK4 |
0.764 | 0.028 | -2 | 0.487 |
TAO3 |
0.763 | 0.004 | 1 | 0.754 |
NEK5 |
0.763 | -0.032 | 1 | 0.800 |
WNK4 |
0.762 | -0.020 | -2 | 0.668 |
PAK5 |
0.762 | 0.005 | -2 | 0.481 |
MEKK3 |
0.762 | -0.123 | 1 | 0.767 |
MEK5 |
0.762 | -0.122 | 2 | 0.785 |
MAPKAPK5 |
0.761 | -0.076 | -3 | 0.704 |
PINK1 |
0.761 | -0.124 | 1 | 0.824 |
CK2A1 |
0.761 | 0.059 | 1 | 0.727 |
CDK6 |
0.760 | 0.104 | 1 | 0.654 |
PERK |
0.760 | -0.133 | -2 | 0.538 |
AKT1 |
0.760 | 0.001 | -3 | 0.704 |
CDK4 |
0.760 | 0.117 | 1 | 0.636 |
PLK4 |
0.759 | -0.105 | 2 | 0.588 |
BRAF |
0.759 | -0.110 | -4 | 0.777 |
TLK1 |
0.759 | -0.107 | -2 | 0.525 |
MARK1 |
0.759 | -0.082 | 4 | 0.706 |
CAMK1G |
0.758 | -0.055 | -3 | 0.739 |
DAPK3 |
0.758 | 0.002 | -3 | 0.783 |
MEKK1 |
0.758 | -0.103 | 1 | 0.756 |
LKB1 |
0.757 | 0.017 | -3 | 0.768 |
SMMLCK |
0.757 | -0.048 | -3 | 0.787 |
AKT3 |
0.757 | 0.032 | -3 | 0.650 |
IRAK4 |
0.757 | -0.048 | 1 | 0.770 |
SGK1 |
0.757 | 0.037 | -3 | 0.629 |
SSTK |
0.756 | -0.048 | 4 | 0.717 |
PKCT |
0.756 | -0.038 | 2 | 0.686 |
PKCE |
0.756 | 0.007 | 2 | 0.686 |
ZAK |
0.756 | -0.134 | 1 | 0.719 |
P70S6K |
0.755 | -0.038 | -3 | 0.693 |
CAMKK2 |
0.755 | -0.053 | -2 | 0.512 |
DAPK1 |
0.755 | 0.003 | -3 | 0.775 |
PKCI |
0.755 | -0.035 | 2 | 0.702 |
EEF2K |
0.755 | 0.072 | 3 | 0.850 |
GAK |
0.755 | -0.014 | 1 | 0.825 |
GCK |
0.754 | 0.015 | 1 | 0.770 |
PDK1 |
0.754 | -0.028 | 1 | 0.758 |
HRI |
0.754 | -0.180 | -2 | 0.558 |
CAMKK1 |
0.754 | -0.114 | -2 | 0.494 |
CAMK1D |
0.753 | -0.024 | -3 | 0.674 |
SNRK |
0.752 | -0.174 | 2 | 0.631 |
TNIK |
0.752 | 0.028 | 3 | 0.901 |
DCAMKL2 |
0.752 | -0.070 | -3 | 0.776 |
ROCK2 |
0.751 | 0.031 | -3 | 0.763 |
PLK2 |
0.750 | -0.028 | -3 | 0.740 |
BUB1 |
0.750 | 0.074 | -5 | 0.688 |
NEK11 |
0.750 | -0.097 | 1 | 0.753 |
MST2 |
0.749 | -0.077 | 1 | 0.767 |
HPK1 |
0.749 | -0.019 | 1 | 0.757 |
MEKK6 |
0.749 | 0.010 | 1 | 0.759 |
HGK |
0.749 | -0.007 | 3 | 0.893 |
SBK |
0.748 | 0.033 | -3 | 0.588 |
TAO2 |
0.748 | -0.078 | 2 | 0.796 |
NEK8 |
0.748 | -0.153 | 2 | 0.772 |
MAP3K15 |
0.747 | 0.018 | 1 | 0.708 |
KHS1 |
0.747 | 0.040 | 1 | 0.735 |
VRK1 |
0.747 | 0.011 | 2 | 0.799 |
CK1A |
0.747 | 0.050 | -3 | 0.529 |
PBK |
0.746 | 0.035 | 1 | 0.755 |
MINK |
0.746 | -0.041 | 1 | 0.743 |
LRRK2 |
0.746 | -0.059 | 2 | 0.797 |
NEK4 |
0.746 | -0.080 | 1 | 0.747 |
MRCKB |
0.745 | -0.004 | -3 | 0.716 |
PDHK3_TYR |
0.745 | 0.271 | 4 | 0.867 |
TAK1 |
0.745 | -0.108 | 1 | 0.779 |
KHS2 |
0.744 | 0.019 | 1 | 0.753 |
PKN1 |
0.743 | -0.030 | -3 | 0.710 |
PHKG2 |
0.743 | -0.104 | -3 | 0.755 |
NEK1 |
0.742 | -0.043 | 1 | 0.761 |
TTBK1 |
0.742 | -0.149 | 2 | 0.615 |
MRCKA |
0.742 | -0.027 | -3 | 0.727 |
LOK |
0.741 | -0.070 | -2 | 0.536 |
CHK2 |
0.741 | -0.020 | -3 | 0.644 |
SLK |
0.740 | -0.076 | -2 | 0.513 |
STK33 |
0.740 | -0.101 | 2 | 0.595 |
DMPK1 |
0.740 | 0.018 | -3 | 0.740 |
CAMK1A |
0.740 | -0.023 | -3 | 0.655 |
YANK3 |
0.736 | -0.015 | 2 | 0.399 |
PKG1 |
0.736 | -0.033 | -2 | 0.423 |
MAP2K6_TYR |
0.736 | 0.090 | -1 | 0.766 |
MAP2K4_TYR |
0.735 | 0.097 | -1 | 0.772 |
MST1 |
0.735 | -0.120 | 1 | 0.743 |
HASPIN |
0.735 | 0.016 | -1 | 0.583 |
MEK2 |
0.733 | -0.167 | 2 | 0.767 |
PDHK4_TYR |
0.733 | 0.066 | 2 | 0.827 |
ROCK1 |
0.733 | -0.008 | -3 | 0.726 |
YSK1 |
0.732 | -0.076 | 2 | 0.758 |
OSR1 |
0.732 | -0.043 | 2 | 0.759 |
IRAK1 |
0.732 | -0.263 | -1 | 0.635 |
PDHK1_TYR |
0.730 | 0.078 | -1 | 0.757 |
CRIK |
0.729 | -0.002 | -3 | 0.705 |
TESK1_TYR |
0.729 | 0.006 | 3 | 0.894 |
TTK |
0.729 | -0.069 | -2 | 0.526 |
LIMK2_TYR |
0.729 | 0.112 | -3 | 0.820 |
MYO3B |
0.728 | -0.012 | 2 | 0.771 |
PKMYT1_TYR |
0.728 | 0.015 | 3 | 0.860 |
MAP2K7_TYR |
0.726 | -0.066 | 2 | 0.809 |
EPHB4 |
0.726 | 0.111 | -1 | 0.691 |
BMPR2_TYR |
0.726 | -0.035 | -1 | 0.732 |
ABL2 |
0.726 | 0.117 | -1 | 0.704 |
TXK |
0.725 | 0.129 | 1 | 0.830 |
ALPHAK3 |
0.725 | -0.023 | -1 | 0.667 |
EPHA6 |
0.722 | 0.041 | -1 | 0.709 |
ABL1 |
0.722 | 0.098 | -1 | 0.702 |
ASK1 |
0.722 | -0.066 | 1 | 0.691 |
TNK2 |
0.721 | 0.116 | 3 | 0.770 |
PINK1_TYR |
0.720 | -0.133 | 1 | 0.812 |
RIPK2 |
0.720 | -0.262 | 1 | 0.682 |
NEK3 |
0.720 | -0.153 | 1 | 0.707 |
MYO3A |
0.720 | -0.069 | 1 | 0.745 |
BIKE |
0.718 | -0.028 | 1 | 0.711 |
RET |
0.717 | -0.033 | 1 | 0.756 |
CSF1R |
0.717 | 0.046 | 3 | 0.811 |
TAO1 |
0.717 | -0.088 | 1 | 0.670 |
FGR |
0.716 | -0.012 | 1 | 0.831 |
LIMK1_TYR |
0.715 | -0.075 | 2 | 0.798 |
TYRO3 |
0.715 | -0.027 | 3 | 0.818 |
SRMS |
0.715 | 0.022 | 1 | 0.826 |
DDR1 |
0.714 | -0.026 | 4 | 0.775 |
YES1 |
0.714 | -0.002 | -1 | 0.721 |
ROS1 |
0.714 | -0.001 | 3 | 0.786 |
JAK2 |
0.713 | -0.035 | 1 | 0.740 |
BLK |
0.712 | 0.046 | -1 | 0.697 |
ITK |
0.712 | 0.028 | -1 | 0.667 |
MST1R |
0.712 | -0.066 | 3 | 0.826 |
EPHA4 |
0.711 | 0.005 | 2 | 0.742 |
TYK2 |
0.711 | -0.113 | 1 | 0.749 |
LCK |
0.711 | 0.021 | -1 | 0.696 |
EPHB1 |
0.710 | 0.002 | 1 | 0.819 |
FER |
0.710 | -0.059 | 1 | 0.839 |
INSRR |
0.710 | -0.042 | 3 | 0.752 |
EPHB3 |
0.709 | 0.009 | -1 | 0.676 |
BMX |
0.709 | 0.016 | -1 | 0.602 |
EPHB2 |
0.709 | 0.007 | -1 | 0.669 |
MERTK |
0.709 | 0.016 | 3 | 0.792 |
TNNI3K_TYR |
0.708 | 0.044 | 1 | 0.761 |
KIT |
0.708 | -0.040 | 3 | 0.807 |
HCK |
0.708 | -0.048 | -1 | 0.696 |
CK1G3 |
0.707 | -0.010 | -3 | 0.486 |
JAK3 |
0.707 | -0.081 | 1 | 0.740 |
DDR2 |
0.706 | 0.075 | 3 | 0.729 |
FYN |
0.705 | 0.015 | -1 | 0.668 |
MET |
0.705 | -0.012 | 3 | 0.804 |
AAK1 |
0.704 | 0.006 | 1 | 0.619 |
TNK1 |
0.704 | 0.004 | 3 | 0.800 |
YANK2 |
0.704 | -0.033 | 2 | 0.412 |
JAK1 |
0.704 | -0.004 | 1 | 0.685 |
STLK3 |
0.703 | -0.173 | 1 | 0.688 |
AXL |
0.702 | -0.046 | 3 | 0.784 |
NEK10_TYR |
0.701 | -0.068 | 1 | 0.637 |
PTK2B |
0.701 | 0.024 | -1 | 0.675 |
KDR |
0.701 | -0.082 | 3 | 0.767 |
TEC |
0.701 | -0.051 | -1 | 0.619 |
FGFR2 |
0.701 | -0.108 | 3 | 0.792 |
EPHA7 |
0.699 | -0.012 | 2 | 0.745 |
CK1G2 |
0.699 | -0.011 | -3 | 0.568 |
WEE1_TYR |
0.698 | -0.075 | -1 | 0.635 |
CSK |
0.698 | 0.014 | 2 | 0.746 |
FLT3 |
0.697 | -0.125 | 3 | 0.818 |
PDGFRB |
0.696 | -0.142 | 3 | 0.814 |
LTK |
0.696 | -0.070 | 3 | 0.740 |
FRK |
0.695 | -0.050 | -1 | 0.703 |
ALK |
0.695 | -0.082 | 3 | 0.719 |
BTK |
0.695 | -0.122 | -1 | 0.640 |
MATK |
0.695 | -0.061 | -1 | 0.637 |
EPHA3 |
0.695 | -0.076 | 2 | 0.710 |
FLT1 |
0.695 | -0.102 | -1 | 0.685 |
PTK2 |
0.695 | 0.005 | -1 | 0.622 |
NTRK1 |
0.694 | -0.136 | -1 | 0.696 |
NTRK3 |
0.694 | -0.063 | -1 | 0.665 |
FGFR1 |
0.694 | -0.140 | 3 | 0.767 |
SRC |
0.694 | -0.036 | -1 | 0.677 |
EPHA5 |
0.693 | -0.037 | 2 | 0.726 |
PTK6 |
0.693 | -0.135 | -1 | 0.635 |
EPHA1 |
0.692 | -0.048 | 3 | 0.785 |
LYN |
0.692 | -0.073 | 3 | 0.721 |
FGFR3 |
0.691 | -0.124 | 3 | 0.764 |
INSR |
0.691 | -0.081 | 3 | 0.735 |
TEK |
0.691 | -0.164 | 3 | 0.748 |
EPHA8 |
0.691 | -0.043 | -1 | 0.647 |
SYK |
0.690 | -0.028 | -1 | 0.631 |
PDGFRA |
0.688 | -0.153 | 3 | 0.815 |
ERBB2 |
0.687 | -0.157 | 1 | 0.703 |
FGFR4 |
0.687 | -0.067 | -1 | 0.657 |
EGFR |
0.686 | -0.078 | 1 | 0.612 |
NTRK2 |
0.684 | -0.178 | 3 | 0.759 |
FLT4 |
0.682 | -0.178 | 3 | 0.752 |
EPHA2 |
0.681 | -0.057 | -1 | 0.617 |
ZAP70 |
0.678 | -0.018 | -1 | 0.579 |
IGF1R |
0.678 | -0.095 | 3 | 0.669 |
ERBB4 |
0.677 | -0.061 | 1 | 0.651 |
MUSK |
0.670 | -0.140 | 1 | 0.623 |
FES |
0.668 | -0.086 | -1 | 0.590 |