Motif 504 (n=175)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1A5D9 | BICDL2 | S330 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A1L390 | PLEKHG3 | S759 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A2RU67 | FAM234B | S52 | ochoa | Protein FAM234B | None |
| O14686 | KMT2D | S2269 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14939 | PLD2 | S146 | psp | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O15534 | PER1 | S601 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43795 | MYO1B | S60 | ochoa | Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa) | Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. {ECO:0000250}. |
| O60291 | MGRN1 | S471 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O60566 | BUB1B | S288 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60841 | EIF5B | S438 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60936 | NOL3 | S147 | ochoa | Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) | [Isoform 1]: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250|UniProtKB:Q62881, ECO:0000250|UniProtKB:Q9D1X0, ECO:0000269|PubMed:15004034, ECO:0000269|PubMed:15509781}. |
| O60941 | DTNB | S351 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75150 | RNF40 | S600 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75410 | TACC1 | S218 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O94885 | SASH1 | S486 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94885 | SASH1 | S1051 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95490 | ADGRL2 | S1374 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| O95696 | BRD1 | S131 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95817 | BAG3 | S315 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P00533 | EGFR | S1130 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04626 | ERBB2 | S1100 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P04626 | ERBB2 | S1235 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05129 | PRKCG | S321 | ochoa | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P06396 | GSN | S51 | ochoa | Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:19666512, ECO:0000269|PubMed:20393563}. |
| P07910 | HNRNPC | S138 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08588 | ADRB1 | S412 | psp | Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:31473062}. |
| P10636 | MAPT | S427 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11362 | FGFR1 | S794 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P11388 | TOP2A | S1449 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12270 | TPR | S648 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P13498 | CYBA | S153 | ochoa|psp | Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) | Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15824103, PubMed:17140397, PubMed:38355798). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:19948736). Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (PubMed:15824103, PubMed:17140397). {ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17140397, ECO:0000269|PubMed:19948736, ECO:0000269|PubMed:38355798}. |
| P14635 | CCNB1 | S95 | ochoa | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P15822 | HIVEP1 | S2350 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P17752 | TPH1 | S260 | psp | Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) | Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. {ECO:0000250|UniProtKB:P17532}. |
| P19634 | SLC9A1 | S796 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P19971 | TYMP | S23 | ochoa | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}. |
| P21580 | TNFAIP3 | S459 | ochoa | Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] | Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269|PubMed:14748687, ECO:0000269|PubMed:15258597, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17961127, ECO:0000269|PubMed:18164316, ECO:0000269|PubMed:18952128, ECO:0000269|PubMed:19494296, ECO:0000269|PubMed:22099304, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:8692885, ECO:0000269|PubMed:9299557, ECO:0000269|PubMed:9882303}. |
| P21860 | ERBB3 | S982 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P22735 | TGM1 | T21 | ochoa | Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:26220141}. |
| P26358 | DNMT1 | S953 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27816 | MAP4 | S580 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30260 | CDC27 | S192 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P31431 | SDC4 | S97 | ochoa | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}. |
| P31629 | HIVEP2 | S1032 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P33240 | CSTF2 | S310 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P40222 | TXLNA | S499 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P41162 | ETV3 | S365 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P46013 | MKI67 | S1736 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46937 | YAP1 | S149 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P46937 | YAP1 | S276 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P49795 | RGS19 | S65 | ochoa | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| P49848 | TAF6 | S623 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P51116 | FXR2 | S533 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P52943 | CRIP2 | S104 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P54132 | BLM | S580 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54753 | EPHB3 | S795 | ochoa | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
| P55884 | EIF3B | S78 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P56945 | BCAR1 | S407 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P98082 | DAB2 | S262 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| P98171 | ARHGAP4 | S831 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| P98177 | FOXO4 | S30 | ochoa | Forkhead box protein O4 (Fork head domain transcription factor AFX1) | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}. |
| Q01201 | RELB | S472 | psp | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q01484 | ANK2 | S3792 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02388 | COL7A1 | S1966 | ochoa | Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Q04206 | RELA | S269 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q04637 | EIF4G1 | Y311 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q05209 | PTPN12 | S670 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05397 | PTK2 | Y861 | ochoa|psp | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q07157 | TJP1 | S1025 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08881 | ITK | S515 | ochoa | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q12778 | FOXO1 | S22 | psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q12888 | TP53BP1 | S623 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13164 | MAPK7 | S496 | psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q13495 | MAMLD1 | S450 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13501 | SQSTM1 | S226 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13625 | TP53BP2 | S682 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q13895 | BYSL | S167 | ochoa | Bystin | Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}. |
| Q14202 | ZMYM3 | S790 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14315 | FLNC | S1256 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14676 | MDC1 | S1605 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14865 | ARID5B | S963 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
| Q15758 | SLC1A5 | S503 | ochoa|psp | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
| Q16204 | CCDC6 | S406 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q2KHR2 | RFX7 | S424 | ochoa | DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) | Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}. |
| Q5JRA6 | MIA3 | S1706 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5JSZ5 | PRRC2B | S914 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5M775 | SPECC1 | S826 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SXM2 | SNAPC4 | S615 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5SY16 | NOL9 | S93 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5SYE7 | NHSL1 | S1190 | ochoa | NHS-like protein 1 | None |
| Q5TC82 | RC3H1 | S772 | ochoa | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25026078, PubMed:25504471). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250|UniProtKB:Q4VGL6, ECO:0000269|PubMed:25026078, ECO:0000269|PubMed:25504471, ECO:0000269|PubMed:25697406, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:31636267}. |
| Q5TCZ1 | SH3PXD2A | S748 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VY43 | PEAR1 | S976 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q5VZ89 | DENND4C | S1115 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63ZY6 | NSUN5P2 | S253 | ochoa | Putative methyltransferase NSUN5C (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 5C) (Williams-Beuren syndrome chromosomal region 20C protein) | May have S-adenosyl-L-methionine-dependent methyl-transferase activity. {ECO:0000305}. |
| Q66K74 | MAP1S | S603 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6IBW4 | NCAPH2 | S308 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6P1N0 | CC2D1A | S203 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6QNY0 | BLOC1S3 | S65 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
| Q6UUV7 | CRTC3 | S443 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6VMQ6 | ATF7IP | S293 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZNJ1 | NBEAL2 | S2012 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZRV2 | FAM83H | S523 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZVM7 | TOM1L2 | S479 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q76N32 | CEP68 | S238 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7L4E1 | MIGA2 | S203 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7L4E1 | MIGA2 | S220 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7Z2K8 | GPRIN1 | S133 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3K3 | POGZ | S434 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q86U44 | METTL3 | S64 | ochoa | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86WB0 | ZC3HC1 | S358 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q8IYB3 | SRRM1 | S242 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZL8 | PELP1 | S991 | psp | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N3F8 | MICALL1 | S295 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4X5 | AFAP1L2 | S158 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5R6 | CCDC33 | S458 | ochoa | Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) | None |
| Q8N612 | FHIP1B | S532 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8NC56 | LEMD2 | S175 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8NEL9 | DDHD1 | S240 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8TDM6 | DLG5 | S1115 | ochoa|psp | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEW8 | PARD3B | S141 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF72 | SHROOM3 | S734 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WU20 | FRS2 | S234 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WUY9 | DEPDC1B | S445 | ochoa | DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) | None |
| Q8WV41 | SNX33 | S146 | ochoa | Sorting nexin-33 (SH3 and PX domain-containing protein 3) | Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q8WVT3 | TRAPPC12 | S171 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q92540 | SMG7 | S897 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92738 | USP6NL | S549 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q96BF3 | TMIGD2 | S238 | psp | Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1) | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
| Q96F05 | C11orf24 | S278 | ochoa | Uncharacterized protein C11orf24 (Protein DM4E3) | None |
| Q96F46 | IL17RA | S731 | ochoa | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
| Q96FF9 | CDCA5 | S114 | ochoa | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96G27 | WBP1 | S212 | ochoa | WW domain-binding protein 1 (WBP-1) | None |
| Q96G42 | KLHDC7B | S142 | ochoa | Kelch domain-containing protein 7B | None |
| Q96HH9 | GRAMD2B | S234 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96ME7 | ZNF512 | S537 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
| Q96MG2 | JSRP1 | S51 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96N64 | PWWP2A | S119 | ochoa | PWWP domain-containing protein 2A | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}. |
| Q99459 | CDC5L | S427 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99543 | DNAJC2 | S541 | ochoa | DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed] | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}. |
| Q99627 | COPS8 | S175 | ochoa | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q99801 | NKX3-1 | S48 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q9BQE9 | BCL7B | S152 | ochoa | B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}. |
| Q9BTV7 | CABLES2 | S269 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9C0C2 | TNKS1BP1 | S1503 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZY8 | MFF | S74 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H000 | MKRN2 | S132 | ochoa | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). {ECO:0000250|UniProtKB:Q9ERV1}. |
| Q9H2M9 | RAB3GAP2 | S915 | ochoa | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
| Q9H3C7 | GGNBP2 | S588 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
| Q9H7P9 | PLEKHG2 | S437 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H910 | JPT2 | S144 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9NQC3 | RTN4 | S114 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NRM7 | LATS2 | S408 | ochoa|psp | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NRM7 | LATS2 | S446 | psp | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9P0U4 | CXXC1 | S264 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P107 | GMIP | S907 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P2Y4 | ZNF219 | S242 | ochoa | Zinc finger protein 219 | Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}. |
| Q9UBU7 | DBF4 | S413 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UGP4 | LIMD1 | S327 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHY1 | NRBP1 | S428 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UKV3 | ACIN1 | S522 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKY7 | CDV3 | S166 | ochoa | Protein CDV3 homolog | None |
| Q9ULD2 | MTUS1 | S773 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULI4 | KIF26A | S1470 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9UMN6 | KMT2B | S1095 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9Y2H9 | MAST1 | S1242 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y4F5 | CEP170B | S511 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6A5 | TACC3 | S497 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6A5 | TACC3 | S501 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| O14965 | AURKA | S104 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| P07814 | EPRS1 | S1122 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| Q9NZQ3 | NCKIPSD | S256 | Sugiyama | NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
| P56645 | PER3 | S634 | SIGNOR|iPTMNet | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
| P10809 | HSPD1 | S159 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P05362 | ICAM1 | S49 | Sugiyama | Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000022 | 4.662 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000022 | 4.662 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000047 | 4.329 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.000057 | 4.244 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.000055 | 4.262 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.000082 | 4.086 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.000153 | 3.816 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.000153 | 3.816 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000127 | 3.897 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.000280 | 3.554 |
| R-HSA-75153 | Apoptotic execution phase | 0.000626 | 3.204 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.001029 | 2.988 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.001141 | 2.943 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.001141 | 2.943 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.001141 | 2.943 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.001556 | 2.808 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 0.001842 | 2.735 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.001814 | 2.741 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.002064 | 2.685 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.002077 | 2.683 |
| R-HSA-8848021 | Signaling by PTK6 | 0.002077 | 2.683 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.002631 | 2.580 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.002631 | 2.580 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.002741 | 2.562 |
| R-HSA-2028269 | Signaling by Hippo | 0.002741 | 2.562 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.003213 | 2.493 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.003456 | 2.461 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.004601 | 2.337 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.005351 | 2.272 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.005776 | 2.238 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.006464 | 2.189 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.007069 | 2.151 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.007730 | 2.112 |
| R-HSA-74160 | Gene expression (Transcription) | 0.007920 | 2.101 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.009814 | 2.008 |
| R-HSA-1640170 | Cell Cycle | 0.009960 | 2.002 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.010022 | 1.999 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.010022 | 1.999 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.010027 | 1.999 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.010699 | 1.971 |
| R-HSA-9909396 | Circadian clock | 0.011002 | 1.959 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.015283 | 1.816 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.015283 | 1.816 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.017249 | 1.763 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.015926 | 1.798 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.013421 | 1.872 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.017564 | 1.755 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.017564 | 1.755 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.017249 | 1.763 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.015283 | 1.816 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.017249 | 1.763 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.017249 | 1.763 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.017695 | 1.752 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.013099 | 1.883 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.015926 | 1.798 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.015620 | 1.806 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.013400 | 1.873 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.013099 | 1.883 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.015926 | 1.798 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.012925 | 1.889 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.018297 | 1.738 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.019819 | 1.703 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.019819 | 1.703 |
| R-HSA-212436 | Generic Transcription Pathway | 0.020581 | 1.687 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.023743 | 1.624 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.023836 | 1.623 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.048472 | 1.315 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.048472 | 1.315 |
| R-HSA-198765 | Signalling to ERK5 | 0.048472 | 1.315 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.048472 | 1.315 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.048472 | 1.315 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.048472 | 1.315 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.048472 | 1.315 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.048472 | 1.315 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.048472 | 1.315 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.048472 | 1.315 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.048472 | 1.315 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.048472 | 1.315 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.048472 | 1.315 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.026098 | 1.583 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.028543 | 1.545 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.028543 | 1.545 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.031076 | 1.508 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.031076 | 1.508 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.033694 | 1.472 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.036395 | 1.439 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.042036 | 1.376 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.047980 | 1.319 |
| R-HSA-72649 | Translation initiation complex formation | 0.042887 | 1.368 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.044600 | 1.351 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.046347 | 1.334 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.046347 | 1.334 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.033694 | 1.472 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.033694 | 1.472 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.049941 | 1.302 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.044972 | 1.347 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.046347 | 1.334 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.028543 | 1.545 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.044600 | 1.351 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.048127 | 1.318 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.033694 | 1.472 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.036395 | 1.439 |
| R-HSA-69481 | G2/M Checkpoints | 0.033153 | 1.479 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.044972 | 1.347 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.049380 | 1.306 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.047980 | 1.319 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.028543 | 1.545 |
| R-HSA-445144 | Signal transduction by L1 | 0.039176 | 1.407 |
| R-HSA-1483166 | Synthesis of PA | 0.048127 | 1.318 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.039176 | 1.407 |
| R-HSA-109704 | PI3K Cascade | 0.036374 | 1.439 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.033694 | 1.472 |
| R-HSA-112399 | IRS-mediated signalling | 0.048127 | 1.318 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.044972 | 1.347 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.048127 | 1.318 |
| R-HSA-109581 | Apoptosis | 0.025873 | 1.587 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.038247 | 1.417 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.044393 | 1.353 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.051061 | 1.292 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.051061 | 1.292 |
| R-HSA-4839726 | Chromatin organization | 0.052194 | 1.282 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.054210 | 1.266 |
| R-HSA-429947 | Deadenylation of mRNA | 0.054210 | 1.266 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.054210 | 1.266 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.055579 | 1.255 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.060220 | 1.220 |
| R-HSA-8941237 | Invadopodia formation | 0.060220 | 1.220 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.060220 | 1.220 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.060220 | 1.220 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.071824 | 1.144 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.083286 | 1.079 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.094606 | 1.024 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.094606 | 1.024 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.094606 | 1.024 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.105787 | 0.976 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.105787 | 0.976 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.105787 | 0.976 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.105787 | 0.976 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.116831 | 0.932 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.127740 | 0.894 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.127740 | 0.894 |
| R-HSA-196025 | Formation of annular gap junctions | 0.127740 | 0.894 |
| R-HSA-190873 | Gap junction degradation | 0.138514 | 0.859 |
| R-HSA-2214320 | Anchoring fibril formation | 0.170048 | 0.769 |
| R-HSA-202670 | ERKs are inactivated | 0.170048 | 0.769 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.180302 | 0.744 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.180302 | 0.744 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.180302 | 0.744 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.180302 | 0.744 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.064051 | 1.193 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.200434 | 0.698 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.210314 | 0.677 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.220073 | 0.657 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.220073 | 0.657 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.096643 | 1.015 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.229712 | 0.639 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.229712 | 0.639 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.239233 | 0.621 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.239233 | 0.621 |
| R-HSA-3928664 | Ephrin signaling | 0.248636 | 0.604 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.248636 | 0.604 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.257924 | 0.589 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.267097 | 0.573 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.267097 | 0.573 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.267097 | 0.573 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.267097 | 0.573 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.267097 | 0.573 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.285107 | 0.545 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.293946 | 0.532 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.063741 | 1.196 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.171491 | 0.766 |
| R-HSA-72187 | mRNA 3'-end processing | 0.171491 | 0.766 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.175898 | 0.755 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.175898 | 0.755 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.319816 | 0.495 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.328228 | 0.484 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.336537 | 0.473 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.234438 | 0.630 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.248147 | 0.605 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.266462 | 0.574 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.307604 | 0.512 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.325768 | 0.487 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.325768 | 0.487 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.273402 | 0.563 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.328228 | 0.484 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.276158 | 0.559 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.276158 | 0.559 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.239233 | 0.621 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.239233 | 0.621 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.124537 | 0.905 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.330290 | 0.481 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.276158 | 0.559 |
| R-HSA-182971 | EGFR downregulation | 0.078012 | 1.108 |
| R-HSA-177929 | Signaling by EGFR | 0.189222 | 0.723 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.210314 | 0.677 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.257924 | 0.589 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.267097 | 0.573 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.319816 | 0.495 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.160844 | 0.794 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.081106 | 1.091 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.210314 | 0.677 |
| R-HSA-180292 | GAB1 signalosome | 0.248636 | 0.604 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.229712 | 0.639 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.145490 | 0.837 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.141242 | 0.850 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.285107 | 0.545 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.293946 | 0.532 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.137021 | 0.863 |
| R-HSA-191650 | Regulation of gap junction activity | 0.071824 | 1.144 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.190430 | 0.720 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.180302 | 0.744 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.180302 | 0.744 |
| R-HSA-72172 | mRNA Splicing | 0.303736 | 0.518 |
| R-HSA-8849473 | PTK6 Expression | 0.116831 | 0.932 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.180302 | 0.744 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.190430 | 0.720 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.239233 | 0.621 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.248636 | 0.604 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.128667 | 0.891 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.080054 | 1.097 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.276158 | 0.559 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.191812 | 0.717 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.080054 | 1.097 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.073300 | 1.135 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.202678 | 0.693 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.100168 | 0.999 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.239004 | 0.622 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.120441 | 0.919 |
| R-HSA-198753 | ERK/MAPK targets | 0.276158 | 0.559 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.323220 | 0.491 |
| R-HSA-190236 | Signaling by FGFR | 0.154926 | 0.810 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.200434 | 0.698 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.088916 | 1.051 |
| R-HSA-68875 | Mitotic Prophase | 0.087107 | 1.060 |
| R-HSA-5693538 | Homology Directed Repair | 0.083544 | 1.078 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.071824 | 1.144 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.094606 | 1.024 |
| R-HSA-390696 | Adrenoceptors | 0.127740 | 0.894 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.127740 | 0.894 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.149155 | 0.826 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.149155 | 0.826 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.190430 | 0.720 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.210314 | 0.677 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.057523 | 1.240 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.124537 | 0.905 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.293946 | 0.532 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.311300 | 0.507 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.311300 | 0.507 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.211708 | 0.674 |
| R-HSA-68877 | Mitotic Prometaphase | 0.270670 | 0.568 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.239004 | 0.622 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.255394 | 0.593 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.164986 | 0.783 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.200434 | 0.698 |
| R-HSA-68886 | M Phase | 0.131264 | 0.882 |
| R-HSA-9694614 | Attachment and Entry | 0.285107 | 0.545 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.271042 | 0.567 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.180302 | 0.744 |
| R-HSA-68882 | Mitotic Anaphase | 0.075664 | 1.121 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.267097 | 0.573 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.076853 | 1.114 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.107806 | 0.967 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.102689 | 0.988 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.064725 | 1.189 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.116831 | 0.932 |
| R-HSA-3000170 | Syndecan interactions | 0.302677 | 0.519 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.311300 | 0.507 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.336537 | 0.473 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.202678 | 0.693 |
| R-HSA-170968 | Frs2-mediated activation | 0.190430 | 0.720 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.138514 | 0.859 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.298486 | 0.525 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.243573 | 0.613 |
| R-HSA-69275 | G2/M Transition | 0.251692 | 0.599 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.257086 | 0.590 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.149155 | 0.826 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.078012 | 1.108 |
| R-HSA-354192 | Integrin signaling | 0.085318 | 1.069 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.124537 | 0.905 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.276158 | 0.559 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.145490 | 0.837 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.336537 | 0.473 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.172880 | 0.762 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.188269 | 0.725 |
| R-HSA-180786 | Extension of Telomeres | 0.202678 | 0.693 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.328228 | 0.484 |
| R-HSA-9664873 | Pexophagy | 0.149155 | 0.826 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.154065 | 0.812 |
| R-HSA-418597 | G alpha (z) signalling events | 0.184765 | 0.733 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.275622 | 0.560 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.319816 | 0.495 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.319816 | 0.495 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.141242 | 0.850 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.275622 | 0.560 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.158389 | 0.800 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.105787 | 0.976 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.200434 | 0.698 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.200434 | 0.698 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.078012 | 1.108 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.216239 | 0.665 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.166830 | 0.778 |
| R-HSA-169893 | Prolonged ERK activation events | 0.220073 | 0.657 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.216239 | 0.665 |
| R-HSA-199991 | Membrane Trafficking | 0.075482 | 1.122 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.094606 | 1.024 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.105787 | 0.976 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.116831 | 0.932 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.127740 | 0.894 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.138514 | 0.859 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.170048 | 0.769 |
| R-HSA-69091 | Polymerase switching | 0.180302 | 0.744 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.180302 | 0.744 |
| R-HSA-69109 | Leading Strand Synthesis | 0.180302 | 0.744 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.220073 | 0.657 |
| R-HSA-209931 | Serotonin and melatonin biosynthesis | 0.220073 | 0.657 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.229712 | 0.639 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.257924 | 0.589 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.316699 | 0.499 |
| R-HSA-422475 | Axon guidance | 0.168897 | 0.772 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.216790 | 0.664 |
| R-HSA-8953854 | Metabolism of RNA | 0.180164 | 0.744 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.319816 | 0.495 |
| R-HSA-9675108 | Nervous system development | 0.132723 | 0.877 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.232739 | 0.633 |
| R-HSA-9664420 | Killing mechanisms | 0.220073 | 0.657 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.220073 | 0.657 |
| R-HSA-194138 | Signaling by VEGF | 0.252749 | 0.597 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.242846 | 0.615 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.083286 | 1.079 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.094606 | 1.024 |
| R-HSA-448706 | Interleukin-1 processing | 0.138514 | 0.859 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.138514 | 0.859 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.190430 | 0.720 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.200434 | 0.698 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.210314 | 0.677 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.220073 | 0.657 |
| R-HSA-1483148 | Synthesis of PG | 0.229712 | 0.639 |
| R-HSA-448424 | Interleukin-17 signaling | 0.252723 | 0.597 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.210314 | 0.677 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.248636 | 0.604 |
| R-HSA-449836 | Other interleukin signaling | 0.257924 | 0.589 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.092759 | 1.033 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.266462 | 0.574 |
| R-HSA-73887 | Death Receptor Signaling | 0.064756 | 1.189 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.190430 | 0.720 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.200434 | 0.698 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.229712 | 0.639 |
| R-HSA-2160916 | Hyaluronan degradation | 0.319816 | 0.495 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.319816 | 0.495 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.234438 | 0.630 |
| R-HSA-162582 | Signal Transduction | 0.117027 | 0.932 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.336537 | 0.473 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.120441 | 0.919 |
| R-HSA-186712 | Regulation of beta-cell development | 0.202678 | 0.693 |
| R-HSA-1266738 | Developmental Biology | 0.320677 | 0.494 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.192866 | 0.715 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.064051 | 1.193 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.276158 | 0.559 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.113021 | 0.947 |
| R-HSA-3371556 | Cellular response to heat stress | 0.236280 | 0.627 |
| R-HSA-3000157 | Laminin interactions | 0.319816 | 0.495 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.336537 | 0.473 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.104028 | 0.983 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.078670 | 1.104 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.085590 | 1.068 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.293946 | 0.532 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.276158 | 0.559 |
| R-HSA-3214842 | HDMs demethylate histones | 0.319816 | 0.495 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.172880 | 0.762 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.115664 | 0.937 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.239233 | 0.621 |
| R-HSA-373760 | L1CAM interactions | 0.220015 | 0.658 |
| R-HSA-166520 | Signaling by NTRKs | 0.153276 | 0.815 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.162619 | 0.789 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.098676 | 1.006 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.293946 | 0.532 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.127740 | 0.894 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.190430 | 0.720 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.200434 | 0.698 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.210314 | 0.677 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.239233 | 0.621 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.207178 | 0.684 |
| R-HSA-201556 | Signaling by ALK | 0.112353 | 0.949 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.148684 | 0.828 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.223250 | 0.651 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.083251 | 1.080 |
| R-HSA-8853659 | RET signaling | 0.100508 | 0.998 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.072580 | 1.139 |
| R-HSA-2262752 | Cellular responses to stress | 0.311349 | 0.507 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.060707 | 1.217 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.083255 | 1.080 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.281740 | 0.550 |
| R-HSA-1538133 | G0 and Early G1 | 0.081640 | 1.088 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.074438 | 1.128 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.293946 | 0.532 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.211708 | 0.674 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.289350 | 0.539 |
| R-HSA-186797 | Signaling by PDGF | 0.216239 | 0.665 |
| R-HSA-5358508 | Mismatch Repair | 0.248636 | 0.604 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.061507 | 1.211 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.257924 | 0.589 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.154065 | 0.812 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.063546 | 1.197 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.236280 | 0.627 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.328828 | 0.483 |
| R-HSA-449147 | Signaling by Interleukins | 0.182357 | 0.739 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.225324 | 0.647 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.286878 | 0.542 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.267942 | 0.572 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.167366 | 0.776 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.061507 | 1.211 |
| R-HSA-216083 | Integrin cell surface interactions | 0.289350 | 0.539 |
| R-HSA-5357801 | Programmed Cell Death | 0.063285 | 1.199 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.089057 | 1.050 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.134793 | 0.870 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.330290 | 0.481 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.092460 | 1.034 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.100913 | 0.996 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.336734 | 0.473 |
| R-HSA-69242 | S Phase | 0.340111 | 0.468 |
| R-HSA-9758941 | Gastrulation | 0.343487 | 0.464 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.344743 | 0.463 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.344743 | 0.463 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.344743 | 0.463 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.344743 | 0.463 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.344743 | 0.463 |
| R-HSA-73614 | Pyrimidine salvage | 0.344743 | 0.463 |
| R-HSA-622312 | Inflammasomes | 0.344743 | 0.463 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.346861 | 0.460 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.350234 | 0.456 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.352768 | 0.453 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.352848 | 0.452 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.352848 | 0.452 |
| R-HSA-5334118 | DNA methylation | 0.352848 | 0.452 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.352848 | 0.452 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.352848 | 0.452 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.352848 | 0.452 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.352848 | 0.452 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.353606 | 0.451 |
| R-HSA-69306 | DNA Replication | 0.356975 | 0.447 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.357234 | 0.447 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.360342 | 0.443 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.360854 | 0.443 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.360854 | 0.443 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.360854 | 0.443 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.360854 | 0.443 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.360854 | 0.443 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.360854 | 0.443 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.360854 | 0.443 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.361689 | 0.442 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.368761 | 0.433 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.368761 | 0.433 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.368761 | 0.433 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.368761 | 0.433 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.368761 | 0.433 |
| R-HSA-186763 | Downstream signal transduction | 0.368761 | 0.433 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.374982 | 0.426 |
| R-HSA-69190 | DNA strand elongation | 0.376570 | 0.424 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.376570 | 0.424 |
| R-HSA-2024096 | HS-GAG degradation | 0.376570 | 0.424 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.379389 | 0.421 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.383782 | 0.416 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.384284 | 0.415 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.384284 | 0.415 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.384284 | 0.415 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.384284 | 0.415 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.384284 | 0.415 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.384284 | 0.415 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.384284 | 0.415 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.384284 | 0.415 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.384284 | 0.415 |
| R-HSA-9733709 | Cardiogenesis | 0.384284 | 0.415 |
| R-HSA-913531 | Interferon Signaling | 0.387175 | 0.412 |
| R-HSA-157579 | Telomere Maintenance | 0.388162 | 0.411 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.388162 | 0.411 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.391902 | 0.407 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.391902 | 0.407 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.391902 | 0.407 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.391902 | 0.407 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.391902 | 0.407 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.391902 | 0.407 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.392529 | 0.406 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.392529 | 0.406 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.392529 | 0.406 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.396882 | 0.401 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.399427 | 0.399 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.399427 | 0.399 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.399427 | 0.399 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.399427 | 0.399 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.399427 | 0.399 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.399427 | 0.399 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.399427 | 0.399 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.399427 | 0.399 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.399427 | 0.399 |
| R-HSA-5205647 | Mitophagy | 0.399427 | 0.399 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.399427 | 0.399 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.405544 | 0.392 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.405544 | 0.392 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.406859 | 0.391 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.406859 | 0.391 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.406859 | 0.391 |
| R-HSA-187687 | Signalling to ERKs | 0.406859 | 0.391 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.409853 | 0.387 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.414200 | 0.383 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.414200 | 0.383 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.414200 | 0.383 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.414200 | 0.383 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.414200 | 0.383 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.414200 | 0.383 |
| R-HSA-111933 | Calmodulin induced events | 0.414200 | 0.383 |
| R-HSA-111997 | CaM pathway | 0.414200 | 0.383 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.417026 | 0.380 |
| R-HSA-72306 | tRNA processing | 0.417026 | 0.380 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.421450 | 0.375 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.421450 | 0.375 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.421450 | 0.375 |
| R-HSA-8948216 | Collagen chain trimerization | 0.421450 | 0.375 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.423601 | 0.373 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.426933 | 0.370 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.426933 | 0.370 |
| R-HSA-8875878 | MET promotes cell motility | 0.428611 | 0.368 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.428611 | 0.368 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.428611 | 0.368 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.430150 | 0.366 |
| R-HSA-69239 | Synthesis of DNA | 0.435377 | 0.361 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.435683 | 0.361 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.435683 | 0.361 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.435683 | 0.361 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.435683 | 0.361 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.439574 | 0.357 |
| R-HSA-1474244 | Extracellular matrix organization | 0.441784 | 0.355 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.442669 | 0.354 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.442669 | 0.354 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.442669 | 0.354 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.442669 | 0.354 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.442669 | 0.354 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.442669 | 0.354 |
| R-HSA-5260271 | Diseases of Immune System | 0.442669 | 0.354 |
| R-HSA-202433 | Generation of second messenger molecules | 0.442669 | 0.354 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.442669 | 0.354 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.443754 | 0.353 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.443754 | 0.353 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.443754 | 0.353 |
| R-HSA-202403 | TCR signaling | 0.447916 | 0.349 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.447916 | 0.349 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.447916 | 0.349 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.449568 | 0.347 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.449568 | 0.347 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.449568 | 0.347 |
| R-HSA-9694548 | Maturation of spike protein | 0.449568 | 0.347 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.449568 | 0.347 |
| R-HSA-2559583 | Cellular Senescence | 0.449634 | 0.347 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.456189 | 0.341 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.456189 | 0.341 |
| R-HSA-167161 | HIV Transcription Initiation | 0.456383 | 0.341 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.456383 | 0.341 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.456383 | 0.341 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.460299 | 0.337 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.463113 | 0.334 |
| R-HSA-111996 | Ca-dependent events | 0.463113 | 0.334 |
| R-HSA-165159 | MTOR signalling | 0.463113 | 0.334 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.469761 | 0.328 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.469761 | 0.328 |
| R-HSA-9710421 | Defective pyroptosis | 0.469761 | 0.328 |
| R-HSA-73621 | Pyrimidine catabolism | 0.469761 | 0.328 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.472520 | 0.326 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.475186 | 0.323 |
| R-HSA-373752 | Netrin-1 signaling | 0.476327 | 0.322 |
| R-HSA-190828 | Gap junction trafficking | 0.476327 | 0.322 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.476327 | 0.322 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.480992 | 0.318 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.482812 | 0.316 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.482812 | 0.316 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.482812 | 0.316 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.482812 | 0.316 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.482812 | 0.316 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.482812 | 0.316 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.484843 | 0.314 |
| R-HSA-72766 | Translation | 0.487692 | 0.312 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.489217 | 0.310 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.489217 | 0.310 |
| R-HSA-9675135 | Diseases of DNA repair | 0.489217 | 0.310 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.489217 | 0.310 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.489217 | 0.310 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.489217 | 0.310 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.489217 | 0.310 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.492515 | 0.308 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.492515 | 0.308 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.492515 | 0.308 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.495543 | 0.305 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.495543 | 0.305 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.495543 | 0.305 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.495543 | 0.305 |
| R-HSA-73886 | Chromosome Maintenance | 0.500379 | 0.301 |
| R-HSA-425410 | Metal ion SLC transporters | 0.501791 | 0.299 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.504282 | 0.297 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.504282 | 0.297 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.507962 | 0.294 |
| R-HSA-73893 | DNA Damage Bypass | 0.507962 | 0.294 |
| R-HSA-73894 | DNA Repair | 0.510598 | 0.292 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.512461 | 0.290 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.512461 | 0.290 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.514057 | 0.289 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.515283 | 0.288 |
| R-HSA-9658195 | Leishmania infection | 0.515283 | 0.288 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.518539 | 0.285 |
| R-HSA-69206 | G1/S Transition | 0.519695 | 0.284 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.520076 | 0.284 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.520076 | 0.284 |
| R-HSA-912446 | Meiotic recombination | 0.520076 | 0.284 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.521562 | 0.283 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.526022 | 0.279 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.526022 | 0.279 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.531894 | 0.274 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.537694 | 0.269 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.543423 | 0.265 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.549081 | 0.260 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.549081 | 0.260 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.549081 | 0.260 |
| R-HSA-75893 | TNF signaling | 0.549081 | 0.260 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.549081 | 0.260 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 0.549081 | 0.260 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.549081 | 0.260 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.549554 | 0.260 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.560188 | 0.252 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.560188 | 0.252 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.560188 | 0.252 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.565639 | 0.247 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.565639 | 0.247 |
| R-HSA-191859 | snRNP Assembly | 0.565639 | 0.247 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.565639 | 0.247 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.565639 | 0.247 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.571023 | 0.243 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.571023 | 0.243 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.571023 | 0.243 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.571023 | 0.243 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.571023 | 0.243 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.571023 | 0.243 |
| R-HSA-379724 | tRNA Aminoacylation | 0.571023 | 0.243 |
| R-HSA-983189 | Kinesins | 0.571023 | 0.243 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.571084 | 0.243 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.576340 | 0.239 |
| R-HSA-450294 | MAP kinase activation | 0.576340 | 0.239 |
| R-HSA-1442490 | Collagen degradation | 0.576340 | 0.239 |
| R-HSA-112043 | PLC beta mediated events | 0.576340 | 0.239 |
| R-HSA-8956321 | Nucleotide salvage | 0.576340 | 0.239 |
| R-HSA-8951664 | Neddylation | 0.576974 | 0.239 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.578094 | 0.238 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.581568 | 0.235 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.581568 | 0.235 |
| R-HSA-9664407 | Parasite infection | 0.581568 | 0.235 |
| R-HSA-1268020 | Mitochondrial protein import | 0.581592 | 0.235 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.581592 | 0.235 |
| R-HSA-9707616 | Heme signaling | 0.581592 | 0.235 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.585021 | 0.233 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.586779 | 0.232 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.586779 | 0.232 |
| R-HSA-373755 | Semaphorin interactions | 0.586779 | 0.232 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.591863 | 0.228 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.591863 | 0.228 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.596358 | 0.224 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.596962 | 0.224 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.601960 | 0.220 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.606895 | 0.217 |
| R-HSA-112040 | G-protein mediated events | 0.606895 | 0.217 |
| R-HSA-72312 | rRNA processing | 0.607173 | 0.217 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.611770 | 0.213 |
| R-HSA-167172 | Transcription of the HIV genome | 0.611770 | 0.213 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.611887 | 0.213 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.621340 | 0.207 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.621340 | 0.207 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.621340 | 0.207 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.621340 | 0.207 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.626037 | 0.203 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.626037 | 0.203 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.626037 | 0.203 |
| R-HSA-157118 | Signaling by NOTCH | 0.628225 | 0.202 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.630676 | 0.200 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.630676 | 0.200 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.630676 | 0.200 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.635257 | 0.197 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.635257 | 0.197 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.639782 | 0.194 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.639782 | 0.194 |
| R-HSA-162587 | HIV Life Cycle | 0.640511 | 0.193 |
| R-HSA-380287 | Centrosome maturation | 0.644251 | 0.191 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.644251 | 0.191 |
| R-HSA-8852135 | Protein ubiquitination | 0.644251 | 0.191 |
| R-HSA-877300 | Interferon gamma signaling | 0.646642 | 0.189 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.648665 | 0.188 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.653024 | 0.185 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.657330 | 0.182 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.657330 | 0.182 |
| R-HSA-4086400 | PCP/CE pathway | 0.657330 | 0.182 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.661582 | 0.179 |
| R-HSA-9659379 | Sensory processing of sound | 0.661582 | 0.179 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.665782 | 0.177 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.665782 | 0.177 |
| R-HSA-6806834 | Signaling by MET | 0.665782 | 0.177 |
| R-HSA-9833482 | PKR-mediated signaling | 0.665782 | 0.177 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.667971 | 0.175 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.669930 | 0.174 |
| R-HSA-977225 | Amyloid fiber formation | 0.669930 | 0.174 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.669930 | 0.174 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.678073 | 0.169 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.682069 | 0.166 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.684503 | 0.165 |
| R-HSA-1500620 | Meiosis | 0.686016 | 0.164 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.686016 | 0.164 |
| R-HSA-416476 | G alpha (q) signalling events | 0.686655 | 0.163 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.689914 | 0.161 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.695467 | 0.158 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.697566 | 0.156 |
| R-HSA-597592 | Post-translational protein modification | 0.700325 | 0.155 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.701322 | 0.154 |
| R-HSA-9663891 | Selective autophagy | 0.701322 | 0.154 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.701322 | 0.154 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.708694 | 0.150 |
| R-HSA-202424 | Downstream TCR signaling | 0.708694 | 0.150 |
| R-HSA-73884 | Base Excision Repair | 0.708694 | 0.150 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.708897 | 0.149 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.712312 | 0.147 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.715885 | 0.145 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.719414 | 0.143 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.722899 | 0.141 |
| R-HSA-9679506 | SARS-CoV Infections | 0.723310 | 0.141 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.725810 | 0.139 |
| R-HSA-1474290 | Collagen formation | 0.726341 | 0.139 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.726341 | 0.139 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.736222 | 0.133 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.736415 | 0.133 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.736415 | 0.133 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.736415 | 0.133 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.740978 | 0.130 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.741019 | 0.130 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.742925 | 0.129 |
| R-HSA-3214847 | HATs acetylate histones | 0.746120 | 0.127 |
| R-HSA-9609690 | HCMV Early Events | 0.747974 | 0.126 |
| R-HSA-70171 | Glycolysis | 0.749275 | 0.125 |
| R-HSA-1483257 | Phospholipid metabolism | 0.751651 | 0.124 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.755469 | 0.122 |
| R-HSA-111885 | Opioid Signalling | 0.761510 | 0.118 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.763673 | 0.117 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.763673 | 0.117 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.764475 | 0.117 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.764475 | 0.117 |
| R-HSA-9833110 | RSV-host interactions | 0.764475 | 0.117 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.770295 | 0.113 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.773152 | 0.112 |
| R-HSA-211000 | Gene Silencing by RNA | 0.773152 | 0.112 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.775973 | 0.110 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.784632 | 0.105 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.786911 | 0.104 |
| R-HSA-1500931 | Cell-Cell communication | 0.789250 | 0.103 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.789562 | 0.103 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.794765 | 0.100 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.799840 | 0.097 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.799840 | 0.097 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.802475 | 0.096 |
| R-HSA-70326 | Glucose metabolism | 0.804790 | 0.094 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.804790 | 0.094 |
| R-HSA-162906 | HIV Infection | 0.813020 | 0.090 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.818922 | 0.087 |
| R-HSA-1643685 | Disease | 0.819402 | 0.087 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.821176 | 0.086 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.821176 | 0.086 |
| R-HSA-392499 | Metabolism of proteins | 0.821667 | 0.085 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.825601 | 0.083 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.825601 | 0.083 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.825601 | 0.083 |
| R-HSA-8939211 | ESR-mediated signaling | 0.830051 | 0.081 |
| R-HSA-168256 | Immune System | 0.833563 | 0.079 |
| R-HSA-8956319 | Nucleotide catabolism | 0.834127 | 0.079 |
| R-HSA-1474165 | Reproduction | 0.838233 | 0.077 |
| R-HSA-9843745 | Adipogenesis | 0.840248 | 0.076 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.842238 | 0.075 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.844203 | 0.074 |
| R-HSA-6798695 | Neutrophil degranulation | 0.847117 | 0.072 |
| R-HSA-9609646 | HCMV Infection | 0.850107 | 0.071 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.851824 | 0.070 |
| R-HSA-5688426 | Deubiquitination | 0.857233 | 0.067 |
| R-HSA-1280218 | Adaptive Immune System | 0.859011 | 0.066 |
| R-HSA-1632852 | Macroautophagy | 0.860830 | 0.065 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.867641 | 0.062 |
| R-HSA-2187338 | Visual phototransduction | 0.872531 | 0.059 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.880284 | 0.055 |
| R-HSA-9609507 | Protein localization | 0.881777 | 0.055 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.884709 | 0.053 |
| R-HSA-9612973 | Autophagy | 0.886147 | 0.052 |
| R-HSA-446728 | Cell junction organization | 0.886199 | 0.052 |
| R-HSA-9610379 | HCMV Late Events | 0.887568 | 0.052 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.888971 | 0.051 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.897030 | 0.047 |
| R-HSA-5619102 | SLC transporter disorders | 0.900839 | 0.045 |
| R-HSA-418555 | G alpha (s) signalling events | 0.906878 | 0.042 |
| R-HSA-195721 | Signaling by WNT | 0.906878 | 0.042 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.909189 | 0.041 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.909189 | 0.041 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.909189 | 0.041 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.911444 | 0.040 |
| R-HSA-168255 | Influenza Infection | 0.915788 | 0.038 |
| R-HSA-168249 | Innate Immune System | 0.916182 | 0.038 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.919919 | 0.036 |
| R-HSA-3781865 | Diseases of glycosylation | 0.920920 | 0.036 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.925556 | 0.034 |
| R-HSA-5617833 | Cilium Assembly | 0.926670 | 0.033 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.927812 | 0.033 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.932003 | 0.031 |
| R-HSA-388396 | GPCR downstream signalling | 0.932858 | 0.030 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.936722 | 0.028 |
| R-HSA-109582 | Hemostasis | 0.937589 | 0.028 |
| R-HSA-6805567 | Keratinization | 0.940799 | 0.027 |
| R-HSA-418990 | Adherens junctions interactions | 0.949107 | 0.023 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.952358 | 0.021 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.955699 | 0.020 |
| R-HSA-15869 | Metabolism of nucleotides | 0.959444 | 0.018 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.959953 | 0.018 |
| R-HSA-372790 | Signaling by GPCR | 0.964065 | 0.016 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.964703 | 0.016 |
| R-HSA-421270 | Cell-cell junction organization | 0.966442 | 0.015 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.967119 | 0.015 |
| R-HSA-418594 | G alpha (i) signalling events | 0.970458 | 0.013 |
| R-HSA-9824446 | Viral Infection Pathways | 0.976472 | 0.010 |
| R-HSA-112316 | Neuronal System | 0.984772 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.991990 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.994603 | 0.002 |
| R-HSA-5663205 | Infectious disease | 0.996266 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 0.996458 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.997183 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999558 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999962 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999998 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.854 | 0.233 | 1 | 0.864 |
COT |
0.853 | 0.090 | 2 | 0.642 |
CDC7 |
0.852 | 0.244 | 1 | 0.891 |
PIM3 |
0.849 | 0.180 | -3 | 0.846 |
HIPK4 |
0.849 | 0.294 | 1 | 0.774 |
CDKL5 |
0.847 | 0.245 | -3 | 0.819 |
MOS |
0.847 | 0.228 | 1 | 0.893 |
PRKD1 |
0.843 | 0.187 | -3 | 0.840 |
CDKL1 |
0.842 | 0.188 | -3 | 0.825 |
NDR2 |
0.841 | 0.098 | -3 | 0.839 |
ICK |
0.840 | 0.266 | -3 | 0.853 |
ERK5 |
0.839 | 0.125 | 1 | 0.836 |
RSK2 |
0.838 | 0.116 | -3 | 0.789 |
NLK |
0.838 | 0.086 | 1 | 0.827 |
PRKD2 |
0.836 | 0.155 | -3 | 0.783 |
SKMLCK |
0.835 | 0.114 | -2 | 0.853 |
MTOR |
0.835 | 0.018 | 1 | 0.779 |
AURC |
0.835 | 0.141 | -2 | 0.690 |
PRPK |
0.834 | -0.040 | -1 | 0.816 |
RAF1 |
0.834 | 0.013 | 1 | 0.825 |
CHAK2 |
0.833 | 0.182 | -1 | 0.808 |
PIM1 |
0.833 | 0.134 | -3 | 0.791 |
SRPK1 |
0.833 | 0.122 | -3 | 0.783 |
P90RSK |
0.832 | 0.088 | -3 | 0.797 |
KIS |
0.832 | 0.111 | 1 | 0.707 |
RSK3 |
0.832 | 0.090 | -3 | 0.786 |
ATR |
0.832 | 0.066 | 1 | 0.811 |
CDK18 |
0.831 | 0.159 | 1 | 0.638 |
CAMK1B |
0.831 | 0.025 | -3 | 0.853 |
NDR1 |
0.830 | 0.039 | -3 | 0.826 |
GRK1 |
0.830 | 0.073 | -2 | 0.746 |
IKKB |
0.829 | -0.060 | -2 | 0.710 |
HIPK2 |
0.829 | 0.197 | 1 | 0.621 |
CDK7 |
0.829 | 0.145 | 1 | 0.702 |
DAPK2 |
0.829 | 0.101 | -3 | 0.860 |
TBK1 |
0.828 | -0.028 | 1 | 0.695 |
DYRK2 |
0.828 | 0.137 | 1 | 0.702 |
CAMLCK |
0.828 | 0.066 | -2 | 0.847 |
ULK2 |
0.827 | -0.115 | 2 | 0.590 |
GCN2 |
0.827 | -0.156 | 2 | 0.605 |
PKN3 |
0.827 | 0.013 | -3 | 0.831 |
MST4 |
0.827 | 0.028 | 2 | 0.678 |
RSK4 |
0.827 | 0.122 | -3 | 0.765 |
PKCD |
0.826 | 0.061 | 2 | 0.601 |
P70S6KB |
0.826 | 0.068 | -3 | 0.795 |
CDK8 |
0.826 | 0.120 | 1 | 0.684 |
WNK1 |
0.825 | -0.014 | -2 | 0.875 |
CDK19 |
0.825 | 0.141 | 1 | 0.650 |
NEK6 |
0.825 | -0.009 | -2 | 0.795 |
BMPR2 |
0.825 | -0.097 | -2 | 0.837 |
P38A |
0.825 | 0.179 | 1 | 0.733 |
PKACG |
0.825 | 0.069 | -2 | 0.770 |
MAK |
0.825 | 0.336 | -2 | 0.934 |
PKN2 |
0.824 | 0.006 | -3 | 0.826 |
NIK |
0.824 | -0.007 | -3 | 0.860 |
IKKE |
0.824 | -0.067 | 1 | 0.693 |
RIPK3 |
0.823 | -0.039 | 3 | 0.733 |
BMPR1B |
0.823 | 0.134 | 1 | 0.870 |
TGFBR2 |
0.823 | -0.023 | -2 | 0.738 |
P38B |
0.823 | 0.178 | 1 | 0.667 |
HIPK1 |
0.823 | 0.165 | 1 | 0.718 |
SRPK2 |
0.822 | 0.096 | -3 | 0.708 |
DSTYK |
0.822 | -0.114 | 2 | 0.648 |
AMPKA1 |
0.822 | 0.052 | -3 | 0.843 |
CDK1 |
0.822 | 0.117 | 1 | 0.666 |
GRK5 |
0.821 | -0.080 | -3 | 0.836 |
MLK3 |
0.821 | 0.046 | 2 | 0.559 |
MAPKAPK2 |
0.821 | 0.081 | -3 | 0.745 |
PKACB |
0.821 | 0.120 | -2 | 0.703 |
CAMK2G |
0.821 | -0.132 | 2 | 0.588 |
PAK1 |
0.821 | 0.049 | -2 | 0.816 |
NUAK2 |
0.821 | -0.014 | -3 | 0.838 |
PDHK4 |
0.820 | -0.255 | 1 | 0.825 |
MLK2 |
0.820 | 0.046 | 2 | 0.620 |
IKKA |
0.820 | -0.003 | -2 | 0.698 |
DYRK1A |
0.820 | 0.169 | 1 | 0.742 |
MLK1 |
0.820 | -0.080 | 2 | 0.605 |
CDK5 |
0.820 | 0.100 | 1 | 0.725 |
LATS2 |
0.819 | 0.004 | -5 | 0.728 |
CLK2 |
0.819 | 0.137 | -3 | 0.764 |
ERK1 |
0.819 | 0.136 | 1 | 0.653 |
PKCA |
0.819 | 0.063 | 2 | 0.563 |
MAPKAPK3 |
0.819 | 0.043 | -3 | 0.778 |
JNK2 |
0.819 | 0.115 | 1 | 0.640 |
CDK17 |
0.818 | 0.104 | 1 | 0.589 |
PKCB |
0.818 | 0.031 | 2 | 0.557 |
MNK2 |
0.817 | 0.033 | -2 | 0.800 |
PKCG |
0.817 | 0.026 | 2 | 0.561 |
LATS1 |
0.817 | 0.082 | -3 | 0.845 |
PKG2 |
0.817 | 0.091 | -2 | 0.716 |
PDHK1 |
0.817 | -0.183 | 1 | 0.802 |
NEK7 |
0.817 | -0.148 | -3 | 0.829 |
PRKX |
0.817 | 0.143 | -3 | 0.690 |
PRKD3 |
0.817 | 0.076 | -3 | 0.756 |
PAK3 |
0.817 | 0.014 | -2 | 0.805 |
IRE1 |
0.816 | -0.041 | 1 | 0.763 |
CAMK2D |
0.816 | -0.046 | -3 | 0.833 |
AURB |
0.816 | 0.072 | -2 | 0.683 |
CLK4 |
0.816 | 0.088 | -3 | 0.773 |
AMPKA2 |
0.816 | 0.052 | -3 | 0.814 |
TGFBR1 |
0.816 | 0.045 | -2 | 0.742 |
GRK7 |
0.815 | 0.079 | 1 | 0.788 |
MASTL |
0.815 | -0.157 | -2 | 0.790 |
MARK4 |
0.815 | -0.056 | 4 | 0.776 |
CDK14 |
0.815 | 0.113 | 1 | 0.674 |
P38D |
0.815 | 0.146 | 1 | 0.598 |
P38G |
0.815 | 0.102 | 1 | 0.582 |
AKT2 |
0.814 | 0.099 | -3 | 0.709 |
PIM2 |
0.814 | 0.117 | -3 | 0.756 |
CLK1 |
0.814 | 0.092 | -3 | 0.749 |
ULK1 |
0.814 | -0.184 | -3 | 0.797 |
PKCZ |
0.814 | 0.025 | 2 | 0.602 |
SGK3 |
0.814 | 0.078 | -3 | 0.767 |
MNK1 |
0.813 | 0.028 | -2 | 0.806 |
HUNK |
0.813 | -0.180 | 2 | 0.614 |
GRK6 |
0.813 | -0.081 | 1 | 0.849 |
CAMK2A |
0.813 | 0.013 | 2 | 0.575 |
FAM20C |
0.813 | -0.037 | 2 | 0.379 |
ALK4 |
0.813 | 0.017 | -2 | 0.773 |
CDK16 |
0.813 | 0.126 | 1 | 0.603 |
TSSK2 |
0.813 | -0.037 | -5 | 0.816 |
SRPK3 |
0.813 | 0.049 | -3 | 0.755 |
CDK3 |
0.813 | 0.108 | 1 | 0.610 |
TSSK1 |
0.813 | 0.002 | -3 | 0.863 |
HIPK3 |
0.812 | 0.133 | 1 | 0.706 |
JNK3 |
0.812 | 0.074 | 1 | 0.674 |
MSK1 |
0.812 | 0.051 | -3 | 0.765 |
CDK13 |
0.811 | 0.043 | 1 | 0.671 |
WNK3 |
0.811 | -0.202 | 1 | 0.783 |
MSK2 |
0.811 | 0.009 | -3 | 0.767 |
DYRK4 |
0.811 | 0.103 | 1 | 0.642 |
DLK |
0.811 | -0.132 | 1 | 0.813 |
NEK9 |
0.811 | -0.139 | 2 | 0.637 |
NIM1 |
0.810 | -0.083 | 3 | 0.740 |
ANKRD3 |
0.810 | -0.134 | 1 | 0.824 |
PKR |
0.810 | -0.009 | 1 | 0.813 |
IRE2 |
0.810 | -0.039 | 2 | 0.571 |
CAMK2B |
0.810 | -0.033 | 2 | 0.540 |
PAK6 |
0.810 | 0.025 | -2 | 0.729 |
ACVR2B |
0.809 | 0.055 | -2 | 0.735 |
BCKDK |
0.809 | -0.165 | -1 | 0.749 |
PRP4 |
0.809 | 0.105 | -3 | 0.806 |
MPSK1 |
0.809 | 0.220 | 1 | 0.778 |
PHKG1 |
0.809 | -0.017 | -3 | 0.817 |
RIPK1 |
0.808 | -0.150 | 1 | 0.771 |
CAMK4 |
0.808 | -0.067 | -3 | 0.802 |
MELK |
0.808 | -0.021 | -3 | 0.794 |
MLK4 |
0.808 | -0.030 | 2 | 0.532 |
CDK10 |
0.808 | 0.102 | 1 | 0.661 |
PAK2 |
0.808 | -0.007 | -2 | 0.799 |
MYLK4 |
0.808 | 0.019 | -2 | 0.772 |
CHAK1 |
0.807 | -0.017 | 2 | 0.639 |
TTBK2 |
0.807 | -0.165 | 2 | 0.523 |
PKCH |
0.807 | -0.026 | 2 | 0.541 |
CDK12 |
0.807 | 0.050 | 1 | 0.642 |
DYRK1B |
0.806 | 0.103 | 1 | 0.675 |
AURA |
0.806 | 0.035 | -2 | 0.641 |
VRK2 |
0.806 | -0.086 | 1 | 0.840 |
GRK4 |
0.806 | -0.150 | -2 | 0.758 |
QSK |
0.805 | -0.007 | 4 | 0.755 |
DYRK3 |
0.805 | 0.103 | 1 | 0.711 |
ACVR2A |
0.805 | 0.004 | -2 | 0.724 |
BMPR1A |
0.804 | 0.088 | 1 | 0.856 |
NEK2 |
0.804 | -0.071 | 2 | 0.641 |
ERK2 |
0.803 | 0.039 | 1 | 0.686 |
NUAK1 |
0.803 | -0.040 | -3 | 0.778 |
PLK1 |
0.803 | -0.117 | -2 | 0.742 |
MOK |
0.803 | 0.239 | 1 | 0.736 |
YSK4 |
0.803 | -0.104 | 1 | 0.750 |
CDK9 |
0.803 | 0.019 | 1 | 0.678 |
ATM |
0.803 | -0.055 | 1 | 0.757 |
DRAK1 |
0.802 | -0.051 | 1 | 0.789 |
DCAMKL1 |
0.802 | 0.001 | -3 | 0.784 |
PKACA |
0.802 | 0.085 | -2 | 0.659 |
ALK2 |
0.802 | 0.001 | -2 | 0.747 |
PASK |
0.802 | 0.068 | -3 | 0.867 |
SMG1 |
0.802 | -0.031 | 1 | 0.755 |
MEK1 |
0.802 | -0.167 | 2 | 0.628 |
MST3 |
0.802 | 0.023 | 2 | 0.663 |
ERK7 |
0.801 | 0.055 | 2 | 0.456 |
TLK2 |
0.801 | -0.040 | 1 | 0.759 |
DNAPK |
0.800 | -0.011 | 1 | 0.683 |
AKT1 |
0.800 | 0.073 | -3 | 0.721 |
SIK |
0.800 | -0.021 | -3 | 0.759 |
CDK2 |
0.800 | -0.007 | 1 | 0.741 |
CHK1 |
0.798 | -0.025 | -3 | 0.810 |
CK1E |
0.798 | -0.014 | -3 | 0.558 |
QIK |
0.798 | -0.130 | -3 | 0.821 |
PLK4 |
0.798 | -0.115 | 2 | 0.465 |
IRAK4 |
0.798 | -0.056 | 1 | 0.761 |
AKT3 |
0.798 | 0.108 | -3 | 0.660 |
P70S6K |
0.798 | 0.029 | -3 | 0.718 |
BRSK1 |
0.797 | -0.063 | -3 | 0.788 |
PKCT |
0.796 | -0.016 | 2 | 0.549 |
DAPK3 |
0.796 | 0.070 | -3 | 0.800 |
GSK3A |
0.796 | 0.044 | 4 | 0.428 |
BUB1 |
0.795 | 0.176 | -5 | 0.770 |
MARK3 |
0.795 | -0.057 | 4 | 0.699 |
SMMLCK |
0.795 | 0.000 | -3 | 0.816 |
NEK5 |
0.795 | -0.061 | 1 | 0.800 |
GRK2 |
0.795 | -0.063 | -2 | 0.666 |
TAO3 |
0.795 | 0.003 | 1 | 0.776 |
BRSK2 |
0.794 | -0.094 | -3 | 0.796 |
PKCE |
0.794 | 0.030 | 2 | 0.560 |
PKCI |
0.794 | -0.017 | 2 | 0.579 |
BRAF |
0.794 | -0.096 | -4 | 0.802 |
CAMK1G |
0.794 | -0.052 | -3 | 0.765 |
WNK4 |
0.793 | -0.103 | -2 | 0.870 |
LKB1 |
0.793 | 0.099 | -3 | 0.820 |
PERK |
0.792 | -0.140 | -2 | 0.778 |
JNK1 |
0.792 | 0.054 | 1 | 0.636 |
ZAK |
0.792 | -0.144 | 1 | 0.750 |
MEK5 |
0.792 | -0.203 | 2 | 0.617 |
DCAMKL2 |
0.792 | -0.051 | -3 | 0.797 |
PLK3 |
0.792 | -0.138 | 2 | 0.551 |
SNRK |
0.792 | -0.183 | 2 | 0.512 |
GSK3B |
0.792 | -0.003 | 4 | 0.423 |
PAK5 |
0.791 | 0.009 | -2 | 0.682 |
MEKK1 |
0.791 | -0.143 | 1 | 0.770 |
PINK1 |
0.791 | -0.094 | 1 | 0.810 |
MEKK2 |
0.791 | -0.121 | 2 | 0.592 |
CDK6 |
0.791 | 0.059 | 1 | 0.654 |
SGK1 |
0.791 | 0.093 | -3 | 0.638 |
GAK |
0.791 | 0.032 | 1 | 0.867 |
PAK4 |
0.790 | 0.012 | -2 | 0.682 |
DAPK1 |
0.790 | 0.049 | -3 | 0.790 |
SSTK |
0.790 | -0.056 | 4 | 0.755 |
MARK2 |
0.790 | -0.098 | 4 | 0.659 |
ROCK2 |
0.789 | 0.105 | -3 | 0.782 |
MAPKAPK5 |
0.789 | -0.079 | -3 | 0.735 |
PHKG2 |
0.789 | -0.075 | -3 | 0.781 |
CK1D |
0.788 | -0.013 | -3 | 0.505 |
CDK4 |
0.788 | 0.059 | 1 | 0.628 |
MRCKB |
0.787 | 0.072 | -3 | 0.737 |
PBK |
0.787 | 0.128 | 1 | 0.809 |
GCK |
0.786 | 0.030 | 1 | 0.786 |
CAMKK2 |
0.786 | -0.037 | -2 | 0.740 |
HRI |
0.786 | -0.202 | -2 | 0.801 |
MEKK3 |
0.786 | -0.232 | 1 | 0.777 |
NEK11 |
0.786 | -0.121 | 1 | 0.762 |
MEKK6 |
0.786 | -0.045 | 1 | 0.782 |
CK1A2 |
0.785 | -0.026 | -3 | 0.506 |
PDK1 |
0.785 | -0.039 | 1 | 0.760 |
PKN1 |
0.785 | 0.002 | -3 | 0.731 |
TAO2 |
0.784 | -0.076 | 2 | 0.656 |
MARK1 |
0.784 | -0.121 | 4 | 0.721 |
MAP3K15 |
0.784 | -0.022 | 1 | 0.737 |
MRCKA |
0.784 | 0.060 | -3 | 0.743 |
CAMK1D |
0.783 | -0.002 | -3 | 0.682 |
CK2A2 |
0.783 | 0.010 | 1 | 0.773 |
CAMKK1 |
0.783 | -0.132 | -2 | 0.727 |
EEF2K |
0.783 | -0.035 | 3 | 0.790 |
NEK8 |
0.782 | -0.160 | 2 | 0.629 |
TLK1 |
0.782 | -0.161 | -2 | 0.750 |
TNIK |
0.781 | 0.015 | 3 | 0.820 |
GRK3 |
0.781 | -0.067 | -2 | 0.616 |
DMPK1 |
0.781 | 0.097 | -3 | 0.757 |
CHK2 |
0.781 | 0.027 | -3 | 0.653 |
TTBK1 |
0.781 | -0.181 | 2 | 0.467 |
CK1G1 |
0.780 | -0.076 | -3 | 0.535 |
NEK4 |
0.780 | -0.073 | 1 | 0.751 |
LOK |
0.780 | -0.012 | -2 | 0.776 |
HGK |
0.780 | -0.024 | 3 | 0.821 |
MINK |
0.779 | -0.031 | 1 | 0.760 |
HPK1 |
0.779 | -0.015 | 1 | 0.761 |
MST2 |
0.778 | -0.101 | 1 | 0.787 |
KHS1 |
0.777 | 0.031 | 1 | 0.744 |
SBK |
0.777 | 0.062 | -3 | 0.599 |
LRRK2 |
0.777 | -0.107 | 2 | 0.656 |
NEK1 |
0.777 | -0.045 | 1 | 0.766 |
KHS2 |
0.776 | 0.033 | 1 | 0.763 |
TAK1 |
0.776 | -0.101 | 1 | 0.799 |
PDHK3_TYR |
0.776 | 0.262 | 4 | 0.869 |
VRK1 |
0.775 | -0.113 | 2 | 0.636 |
SLK |
0.775 | -0.036 | -2 | 0.724 |
CRIK |
0.774 | 0.095 | -3 | 0.727 |
CAMK1A |
0.773 | 0.004 | -3 | 0.669 |
PLK2 |
0.773 | -0.051 | -3 | 0.786 |
CK2A1 |
0.773 | -0.008 | 1 | 0.752 |
IRAK1 |
0.772 | -0.264 | -1 | 0.693 |
PKG1 |
0.771 | 0.026 | -2 | 0.645 |
STK33 |
0.771 | -0.156 | 2 | 0.466 |
ROCK1 |
0.771 | 0.050 | -3 | 0.746 |
YSK1 |
0.770 | -0.073 | 2 | 0.628 |
YANK3 |
0.769 | -0.053 | 2 | 0.308 |
MST1 |
0.769 | -0.115 | 1 | 0.763 |
TTK |
0.767 | -0.028 | -2 | 0.758 |
LIMK2_TYR |
0.766 | 0.168 | -3 | 0.867 |
TESK1_TYR |
0.765 | 0.074 | 3 | 0.852 |
MEK2 |
0.765 | -0.209 | 2 | 0.607 |
MAP2K4_TYR |
0.764 | 0.099 | -1 | 0.828 |
OSR1 |
0.763 | -0.070 | 2 | 0.612 |
PDHK4_TYR |
0.762 | 0.045 | 2 | 0.669 |
PKMYT1_TYR |
0.762 | 0.049 | 3 | 0.834 |
MYO3B |
0.762 | -0.012 | 2 | 0.657 |
BIKE |
0.762 | 0.051 | 1 | 0.760 |
NEK3 |
0.761 | -0.118 | 1 | 0.720 |
EPHA6 |
0.761 | 0.076 | -1 | 0.820 |
MAP2K6_TYR |
0.761 | 0.006 | -1 | 0.835 |
HASPIN |
0.761 | -0.019 | -1 | 0.659 |
EPHB4 |
0.760 | 0.102 | -1 | 0.786 |
PDHK1_TYR |
0.759 | 0.035 | -1 | 0.847 |
MAP2K7_TYR |
0.757 | -0.144 | 2 | 0.649 |
BMPR2_TYR |
0.757 | -0.024 | -1 | 0.831 |
RIPK2 |
0.756 | -0.289 | 1 | 0.697 |
ASK1 |
0.756 | -0.113 | 1 | 0.721 |
TNK2 |
0.755 | 0.131 | 3 | 0.784 |
MYO3A |
0.755 | -0.067 | 1 | 0.737 |
CK1A |
0.754 | -0.033 | -3 | 0.414 |
TXK |
0.754 | 0.113 | 1 | 0.871 |
TAO1 |
0.753 | -0.089 | 1 | 0.687 |
RET |
0.752 | -0.022 | 1 | 0.768 |
ABL2 |
0.752 | 0.054 | -1 | 0.752 |
ROS1 |
0.752 | 0.018 | 3 | 0.757 |
LCK |
0.751 | 0.124 | -1 | 0.799 |
TYRO3 |
0.751 | -0.040 | 3 | 0.781 |
PINK1_TYR |
0.751 | -0.190 | 1 | 0.818 |
AAK1 |
0.751 | 0.094 | 1 | 0.672 |
ALPHAK3 |
0.751 | -0.057 | -1 | 0.721 |
BLK |
0.750 | 0.114 | -1 | 0.806 |
ABL1 |
0.750 | 0.033 | -1 | 0.746 |
YES1 |
0.749 | 0.008 | -1 | 0.817 |
LIMK1_TYR |
0.749 | -0.101 | 2 | 0.655 |
MST1R |
0.749 | -0.048 | 3 | 0.803 |
EPHA4 |
0.748 | 0.004 | 2 | 0.572 |
FGR |
0.748 | -0.016 | 1 | 0.855 |
CSF1R |
0.747 | -0.018 | 3 | 0.774 |
DDR1 |
0.747 | -0.087 | 4 | 0.814 |
JAK2 |
0.747 | -0.038 | 1 | 0.763 |
EPHB1 |
0.746 | 0.020 | 1 | 0.855 |
HCK |
0.745 | 0.011 | -1 | 0.790 |
TYK2 |
0.745 | -0.110 | 1 | 0.765 |
EPHB3 |
0.745 | 0.016 | -1 | 0.768 |
SRMS |
0.744 | -0.005 | 1 | 0.864 |
FER |
0.744 | -0.052 | 1 | 0.882 |
EPHB2 |
0.744 | 0.021 | -1 | 0.767 |
TNK1 |
0.744 | 0.014 | 3 | 0.762 |
JAK1 |
0.743 | 0.070 | 1 | 0.707 |
INSRR |
0.743 | -0.053 | 3 | 0.747 |
MERTK |
0.742 | -0.015 | 3 | 0.772 |
JAK3 |
0.742 | -0.066 | 1 | 0.757 |
ITK |
0.742 | -0.015 | -1 | 0.738 |
TNNI3K_TYR |
0.741 | 0.006 | 1 | 0.763 |
KDR |
0.739 | -0.065 | 3 | 0.752 |
EPHA7 |
0.739 | 0.004 | 2 | 0.573 |
FYN |
0.739 | 0.035 | -1 | 0.788 |
DDR2 |
0.738 | 0.029 | 3 | 0.752 |
ALK |
0.738 | -0.017 | 3 | 0.733 |
AXL |
0.738 | -0.056 | 3 | 0.768 |
BMX |
0.737 | -0.019 | -1 | 0.659 |
MET |
0.737 | -0.035 | 3 | 0.786 |
FGFR2 |
0.737 | -0.117 | 3 | 0.798 |
PDGFRB |
0.737 | -0.110 | 3 | 0.789 |
KIT |
0.736 | -0.094 | 3 | 0.778 |
LTK |
0.736 | -0.054 | 3 | 0.754 |
NEK10_TYR |
0.735 | -0.030 | 1 | 0.641 |
TEK |
0.734 | -0.111 | 3 | 0.735 |
PTK2B |
0.734 | 0.000 | -1 | 0.728 |
STLK3 |
0.734 | -0.225 | 1 | 0.708 |
TEC |
0.733 | -0.061 | -1 | 0.668 |
EPHA1 |
0.733 | -0.043 | 3 | 0.770 |
FGFR1 |
0.732 | -0.121 | 3 | 0.769 |
FLT3 |
0.732 | -0.134 | 3 | 0.779 |
EPHA3 |
0.731 | -0.092 | 2 | 0.551 |
YANK2 |
0.731 | -0.086 | 2 | 0.305 |
PDGFRA |
0.730 | -0.127 | 3 | 0.789 |
FRK |
0.730 | -0.065 | -1 | 0.785 |
LYN |
0.729 | -0.037 | 3 | 0.703 |
PTK2 |
0.727 | 0.011 | -1 | 0.772 |
PTK6 |
0.727 | -0.114 | -1 | 0.655 |
BTK |
0.727 | -0.161 | -1 | 0.694 |
EPHA5 |
0.726 | -0.052 | 2 | 0.544 |
EPHA8 |
0.726 | -0.038 | -1 | 0.752 |
SRC |
0.726 | -0.037 | -1 | 0.780 |
NTRK1 |
0.726 | -0.169 | -1 | 0.763 |
FLT1 |
0.725 | -0.127 | -1 | 0.780 |
INSR |
0.725 | -0.121 | 3 | 0.721 |
WEE1_TYR |
0.725 | -0.142 | -1 | 0.677 |
FGFR3 |
0.725 | -0.152 | 3 | 0.772 |
ERBB2 |
0.724 | -0.160 | 1 | 0.748 |
MATK |
0.723 | -0.098 | -1 | 0.682 |
NTRK3 |
0.723 | -0.091 | -1 | 0.715 |
NTRK2 |
0.721 | -0.170 | 3 | 0.749 |
FLT4 |
0.720 | -0.193 | 3 | 0.748 |
CSK |
0.719 | -0.101 | 2 | 0.575 |
CK1G3 |
0.718 | -0.087 | -3 | 0.368 |
SYK |
0.718 | -0.023 | -1 | 0.742 |
EPHA2 |
0.718 | -0.051 | -1 | 0.716 |
FGFR4 |
0.716 | -0.104 | -1 | 0.715 |
EGFR |
0.715 | -0.106 | 1 | 0.655 |
IGF1R |
0.710 | -0.137 | 3 | 0.664 |
ERBB4 |
0.707 | -0.076 | 1 | 0.684 |
MUSK |
0.706 | -0.146 | 1 | 0.649 |
FES |
0.705 | -0.084 | -1 | 0.640 |
CK1G2 |
0.704 | -0.079 | -3 | 0.457 |
ZAP70 |
0.701 | -0.041 | -1 | 0.664 |