Motif 503 (n=174)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2605 | ochoa | Snf2 related CREBBP activator protein | None |
| A0FGR8 | ESYT2 | S738 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A4FU01 | MTMR11 | S175 | ochoa | Myotubularin-related protein 11 (Cisplatin resistance-associated protein) (hCRA) (Inactive phosphatidylinositol 3-phosphatase 11) | None |
| O00139 | KIF2A | S135 | ochoa|psp | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O00425 | IGF2BP3 | S179 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O00571 | DDX3X | S23 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14827 | RASGRF2 | S793 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O14974 | PPP1R12A | S903 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O14976 | GAK | S1091 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O43166 | SIPA1L1 | S1428 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43303 | CCP110 | S511 | ochoa | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}. |
| O60238 | BNIP3L | S82 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O60271 | SPAG9 | S185 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60716 | CTNND1 | S225 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75381 | PEX14 | S260 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75427 | LRCH4 | S506 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75427 | LRCH4 | S512 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75533 | SF3B1 | S344 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75582 | RPS6KA5 | S376 | ochoa|psp | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| O75815 | BCAR3 | S78 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O75815 | BCAR3 | S353 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O95785 | WIZ | S1122 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95817 | BAG3 | S264 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O95817 | BAG3 | S274 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P05412 | JUN | S58 | ochoa | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
| P08514 | ITGA2B | S427 | ochoa | Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:9111081}. |
| P08581 | MET | S985 | psp | Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}. |
| P10398 | ARAF | S157 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P10451 | SPP1 | S219 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10636 | MAPT | Y514 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P14598 | NCF1 | S283 | psp | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P19634 | SLC9A1 | S766 | psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P23588 | EIF4B | S52 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P26045 | PTPN3 | S454 | ochoa | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P46100 | ATRX | S651 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46379 | BAG6 | S99 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P46821 | MAP1B | S1247 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49023 | PXN | S91 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49790 | NUP153 | S614 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S773 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49916 | LIG3 | S227 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P51608 | MECP2 | S65 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P52948 | NUP98 | S1023 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P52948 | NUP98 | S1055 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P53396 | ACLY | S444 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P55211 | CASP9 | S302 | ochoa | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}. |
| P78559 | MAP1A | S891 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78559 | MAP1A | S1198 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P80723 | BASP1 | S177 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P82094 | TMF1 | S155 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P98175 | RBM10 | S718 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q00536 | CDK16 | S90 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00587 | CDC42EP1 | S62 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q07343 | PDE4B | S140 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}. |
| Q12774 | ARHGEF5 | S978 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12888 | TP53BP1 | S349 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13469 | NFATC2 | S790 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13586 | STIM1 | S595 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q13586 | STIM1 | S613 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14008 | CKAP5 | S825 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14157 | UBAP2L | S462 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14244 | MAP7 | S36 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14244 | MAP7 | S235 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14676 | MDC1 | S981 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14680 | MELK | S400 | ochoa | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14980 | NUMA1 | S1847 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15059 | BRD3 | S254 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15149 | PLEC | Y4615 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15398 | DLGAP5 | S624 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15796 | SMAD2 | S240 | psp | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q4L180 | FILIP1L | S921 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
| Q53ET0 | CRTC2 | S178 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q562E7 | WDR81 | S681 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5R372 | RABGAP1L | S108 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5SXM2 | SNAPC4 | S615 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5T011 | SZT2 | S1194 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T1R4 | HIVEP3 | S1012 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T200 | ZC3H13 | S333 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T200 | ZC3H13 | S341 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5TCZ1 | SH3PXD2A | S1038 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VT25 | CDC42BPA | S1651 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q641Q2 | WASHC2A | S991 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6NV74 | CRACDL | S316 | ochoa | CRACD-like protein | None |
| Q6PJG2 | MIDEAS | S700 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6UWD8 | C16orf54 | S179 | ochoa | Transmembrane protein C16orf54 | None |
| Q6UXY1 | BAIAP2L2 | S220 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6VY07 | PACS1 | S523 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZRS2 | SRCAP | S2782 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZSR9 | None | S285 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q7KZI7 | MARK2 | S387 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7KZI7 | MARK2 | S493 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L7X3 | TAOK1 | S172 | ochoa | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z3B3 | KANSL1 | S979 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z422 | SZRD1 | S68 | ochoa | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | None |
| Q86UE4 | MTDH | S339 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UU0 | BCL9L | S942 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU0 | BCL9L | S949 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU0 | BCL9L | S982 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86X02 | CDR2L | S303 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q86YV5 | PRAG1 | S777 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q86YW5 | TREML1 | S205 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IVJ1 | SLC41A1 | S71 | ochoa | Solute carrier family 41 member 1 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}. |
| Q8IZT6 | ASPM | S420 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N4C8 | MINK1 | S749 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4C8 | MINK1 | S903 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N8K9 | KIAA1958 | S79 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NEM7 | SUPT20H | S376 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NEZ4 | KMT2C | S1878 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TB45 | DEPTOR | S260 | ochoa|psp | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8TER5 | ARHGEF40 | S1469 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8WUA7 | TBC1D22A | S145 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q8WV41 | SNX33 | S72 | ochoa | Sorting nexin-33 (SH3 and PX domain-containing protein 3) | Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q8WXG6 | MADD | S813 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q92609 | TBC1D5 | S539 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92614 | MYO18A | S140 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92729 | PTPRU | S848 | ochoa | Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}. |
| Q92738 | USP6NL | S631 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q92750 | TAF4B | S59 | ochoa | Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) | Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}. |
| Q92793 | CREBBP | S78 | psp | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92945 | KHSRP | S120 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96CP6 | GRAMD1A | S252 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96EC8 | YIPF6 | S24 | ochoa | Protein YIPF6 (YIP1 family member 6) | May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}. |
| Q96FS4 | SIPA1 | S834 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96HC4 | PDLIM5 | S372 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JM3 | CHAMP1 | S367 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96N21 | TEPSIN | S351 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96PU5 | NEDD4L | S335 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q99081 | TCF12 | S348 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99501 | GAS2L1 | S595 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99590 | SCAF11 | S333 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99640 | PKMYT1 | S89 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q99700 | ATXN2 | S669 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99856 | ARID3A | S357 | ochoa | AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) | Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}. |
| Q9BQE9 | BCL7B | S107 | ochoa | B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}. |
| Q9BRK4 | LZTS2 | S296 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BT25 | HAUS8 | S124 | psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BTA9 | WAC | S520 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BZL4 | PPP1R12C | S399 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0B5 | ZDHHC5 | S679 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9H0D6 | XRN2 | S470 | ochoa | 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) | Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}. |
| Q9H2K8 | TAOK3 | S168 | ochoa | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
| Q9H910 | JPT2 | S92 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HCE1 | MOV10 | S966 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9NQS7 | INCENP | S291 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NRA0 | SPHK2 | S399 | ochoa | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
| Q9NWH9 | SLTM | S1014 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NYF8 | BCLAF1 | S643 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYV4 | CDK12 | S288 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P206 | NHSL3 | S322 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P206 | NHSL3 | S526 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P2G1 | ANKIB1 | S438 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9UBW5 | BIN2 | S364 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UER7 | DAXX | S683 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UK32 | RPS6KA6 | S389 | ochoa|psp | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9UMD9 | COL17A1 | S62 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UPQ0 | LIMCH1 | S518 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPU5 | USP24 | S1136 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UQ35 | SRRM2 | Y1049 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1436 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2421 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB8 | BAIAP2 | S256 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y2H0 | DLGAP4 | S603 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2H0 | DLGAP4 | S724 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2H5 | PLEKHA6 | S461 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2R2 | PTPN22 | S414 | ochoa | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}. |
| Q9Y4F5 | CEP170B | S706 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y520 | PRRC2C | S2665 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5X2 | SNX8 | S441 | ochoa | Sorting nexin-8 | May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. {ECO:0000269|PubMed:19782049}. |
| Q9Y608 | LRRFIP2 | S309 | ochoa | Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}. |
| Q5VT52 | RPRD2 | S1180 | Sugiyama | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| O60566 | BUB1B | S686 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| P51617 | IRAK1 | S596 | Sugiyama | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| Q9C0C2 | TNKS1BP1 | S1046 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| Q9NQU5 | PAK6 | S231 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.000003 | 5.549 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000026 | 4.582 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000067 | 4.176 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000076 | 4.121 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000076 | 4.121 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000097 | 4.014 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000097 | 4.014 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000109 | 3.963 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.000119 | 3.926 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.000119 | 3.926 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000097 | 4.014 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000109 | 3.963 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000122 | 3.914 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.000256 | 3.592 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.000256 | 3.592 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.000256 | 3.592 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.000256 | 3.592 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000256 | 3.592 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.000256 | 3.592 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000136 | 3.865 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000207 | 3.684 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000229 | 3.641 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000169 | 3.772 |
| R-HSA-68877 | Mitotic Prometaphase | 0.000188 | 3.726 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000229 | 3.641 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.000229 | 3.641 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.000252 | 3.599 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000187 | 3.727 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000207 | 3.684 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.000323 | 3.491 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.000394 | 3.404 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.000429 | 3.367 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000542 | 3.266 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.000537 | 3.270 |
| R-HSA-1640170 | Cell Cycle | 0.000753 | 3.123 |
| R-HSA-68886 | M Phase | 0.000821 | 3.085 |
| R-HSA-212436 | Generic Transcription Pathway | 0.000968 | 3.014 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000981 | 3.008 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.001013 | 2.995 |
| R-HSA-3371556 | Cellular response to heat stress | 0.001013 | 2.995 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.001028 | 2.988 |
| R-HSA-191859 | snRNP Assembly | 0.001121 | 2.951 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.001121 | 2.951 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.001275 | 2.895 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.001357 | 2.867 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.001486 | 2.828 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.001520 | 2.818 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.001563 | 2.806 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.002051 | 2.688 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.002234 | 2.651 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.002548 | 2.594 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.002627 | 2.581 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.002416 | 2.617 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.002627 | 2.581 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.002826 | 2.549 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.003018 | 2.520 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.003257 | 2.487 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.003285 | 2.484 |
| R-HSA-73887 | Death Receptor Signaling | 0.003892 | 2.410 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.003913 | 2.407 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.003976 | 2.401 |
| R-HSA-162587 | HIV Life Cycle | 0.004271 | 2.369 |
| R-HSA-68875 | Mitotic Prophase | 0.004695 | 2.328 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.005262 | 2.279 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.005397 | 2.268 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.006024 | 2.220 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.006024 | 2.220 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.006672 | 2.176 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.007234 | 2.141 |
| R-HSA-162906 | HIV Infection | 0.007966 | 2.099 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.008545 | 2.068 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.008449 | 2.073 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.009051 | 2.043 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.008545 | 2.068 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.009099 | 2.041 |
| R-HSA-70171 | Glycolysis | 0.009385 | 2.028 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.009955 | 2.002 |
| R-HSA-162582 | Signal Transduction | 0.010570 | 1.976 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.011459 | 1.941 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.011725 | 1.931 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.012367 | 1.908 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.012367 | 1.908 |
| R-HSA-211000 | Gene Silencing by RNA | 0.012367 | 1.908 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.012769 | 1.894 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.014525 | 1.838 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.013324 | 1.875 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.014746 | 1.831 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.014746 | 1.831 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.014746 | 1.831 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.014746 | 1.831 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.014791 | 1.830 |
| R-HSA-70326 | Glucose metabolism | 0.017952 | 1.746 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.018389 | 1.735 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.018407 | 1.735 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.022476 | 1.648 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.020337 | 1.692 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.021914 | 1.659 |
| R-HSA-68882 | Mitotic Anaphase | 0.019577 | 1.708 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.019979 | 1.699 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.022368 | 1.650 |
| R-HSA-9734091 | Drug-mediated inhibition of MET activation | 0.022595 | 1.646 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.023853 | 1.622 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.024479 | 1.611 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.024779 | 1.606 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.025936 | 1.586 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.026982 | 1.569 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.028934 | 1.539 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.032121 | 1.493 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 0.033702 | 1.472 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 0.033702 | 1.472 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 0.033702 | 1.472 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.038715 | 1.412 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.041332 | 1.384 |
| R-HSA-9609690 | HCMV Early Events | 0.038100 | 1.419 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.041628 | 1.381 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.037734 | 1.423 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.036286 | 1.440 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.038715 | 1.412 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.039210 | 1.407 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.042250 | 1.374 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.044682 | 1.350 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.055539 | 1.255 |
| R-HSA-8865999 | MET activates PTPN11 | 0.055539 | 1.255 |
| R-HSA-8941237 | Invadopodia formation | 0.055539 | 1.255 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.066273 | 1.179 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.066273 | 1.179 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.076886 | 1.114 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.076886 | 1.114 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.076886 | 1.114 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.087379 | 1.059 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.087379 | 1.059 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.087379 | 1.059 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.108010 | 0.967 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.108010 | 0.967 |
| R-HSA-444257 | RSK activation | 0.118150 | 0.928 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.118150 | 0.928 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.118150 | 0.928 |
| R-HSA-8875656 | MET receptor recycling | 0.118150 | 0.928 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.118150 | 0.928 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.128177 | 0.892 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.138089 | 0.860 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.147890 | 0.830 |
| R-HSA-429947 | Deadenylation of mRNA | 0.046756 | 1.330 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.157580 | 0.802 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.157580 | 0.802 |
| R-HSA-8851805 | MET activates RAS signaling | 0.167160 | 0.777 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.167160 | 0.777 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.167160 | 0.777 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.167160 | 0.777 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.195256 | 0.709 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.195256 | 0.709 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.073997 | 1.131 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.204410 | 0.689 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.204410 | 0.689 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.213460 | 0.671 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.222408 | 0.653 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.101425 | 0.994 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.048673 | 1.313 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.048673 | 1.313 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.053786 | 1.269 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.066667 | 1.176 |
| R-HSA-380287 | Centrosome maturation | 0.070584 | 1.151 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.203388 | 0.692 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.176632 | 0.753 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.105395 | 0.977 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.108665 | 0.964 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.138089 | 0.860 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.157580 | 0.802 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.108665 | 0.964 |
| R-HSA-111458 | Formation of apoptosome | 0.138089 | 0.860 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.138089 | 0.860 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.147890 | 0.830 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.118150 | 0.928 |
| R-HSA-9839394 | TGFBR3 expression | 0.049561 | 1.305 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.213460 | 0.671 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.070763 | 1.150 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.166563 | 0.778 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.167160 | 0.777 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.127325 | 0.895 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.127325 | 0.895 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.127325 | 0.895 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.076886 | 1.114 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.185997 | 0.730 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.213460 | 0.671 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.090836 | 1.042 |
| R-HSA-6806942 | MET Receptor Activation | 0.097753 | 1.010 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.128177 | 0.892 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.213460 | 0.671 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.178714 | 0.748 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.148221 | 0.829 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.148221 | 0.829 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.097753 | 1.010 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.157580 | 0.802 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.105028 | 0.979 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.154567 | 0.811 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.128177 | 0.892 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.127325 | 0.895 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.135689 | 0.867 |
| R-HSA-8875791 | MET activates STAT3 | 0.055539 | 1.255 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.076886 | 1.114 |
| R-HSA-199920 | CREB phosphorylation | 0.097753 | 1.010 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.097753 | 1.010 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.157580 | 0.802 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.157580 | 0.802 |
| R-HSA-525793 | Myogenesis | 0.052425 | 1.280 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.176632 | 0.753 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.176632 | 0.753 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.204410 | 0.689 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.107761 | 0.968 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.211699 | 0.674 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.167160 | 0.777 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.061357 | 1.212 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.118150 | 0.928 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.061357 | 1.212 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.108665 | 0.964 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.070763 | 1.150 |
| R-HSA-1502540 | Signaling by Activin | 0.195256 | 0.709 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.222408 | 0.653 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.148056 | 0.830 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.073997 | 1.131 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.172836 | 0.762 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.200587 | 0.698 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.116038 | 0.935 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.076886 | 1.114 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.138089 | 0.860 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.138089 | 0.860 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.213460 | 0.671 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.176249 | 0.754 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.161752 | 0.791 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.134988 | 0.870 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.174648 | 0.758 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.129948 | 0.886 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.129948 | 0.886 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.129948 | 0.886 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.097753 | 1.010 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.172836 | 0.762 |
| R-HSA-450294 | MAP kinase activation | 0.045405 | 1.343 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.181287 | 0.742 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.053786 | 1.269 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.195612 | 0.709 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.046756 | 1.330 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.213460 | 0.671 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.195612 | 0.709 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.204338 | 0.690 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.159016 | 0.799 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.204338 | 0.690 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.127325 | 0.895 |
| R-HSA-448424 | Interleukin-17 signaling | 0.060987 | 1.215 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.076886 | 1.114 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.118150 | 0.928 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.128177 | 0.892 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.128177 | 0.892 |
| R-HSA-428540 | Activation of RAC1 | 0.157580 | 0.802 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.176632 | 0.753 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.195256 | 0.709 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.204410 | 0.689 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.131143 | 0.882 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.150607 | 0.822 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.129408 | 0.888 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.098424 | 1.007 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.207267 | 0.683 |
| R-HSA-157118 | Signaling by NOTCH | 0.178464 | 0.748 |
| R-HSA-446728 | Cell junction organization | 0.128205 | 0.892 |
| R-HSA-8953854 | Metabolism of RNA | 0.114092 | 0.943 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.076886 | 1.114 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.087379 | 1.059 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.087379 | 1.059 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.087379 | 1.059 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.185997 | 0.730 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.195256 | 0.709 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.222408 | 0.653 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.097858 | 1.009 |
| R-HSA-3214847 | HATs acetylate histones | 0.132507 | 0.878 |
| R-HSA-9609646 | HCMV Infection | 0.091016 | 1.041 |
| R-HSA-1500931 | Cell-Cell communication | 0.188438 | 0.725 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.222408 | 0.653 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.091649 | 1.038 |
| R-HSA-69275 | G2/M Transition | 0.087504 | 1.058 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.090266 | 1.044 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.185997 | 0.730 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.195256 | 0.709 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.087383 | 1.059 |
| R-HSA-2262752 | Cellular responses to stress | 0.139103 | 0.857 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.176632 | 0.753 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.164502 | 0.784 |
| R-HSA-2559583 | Cellular Senescence | 0.194444 | 0.711 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.049619 | 1.304 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.164502 | 0.784 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.150896 | 0.821 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.180719 | 0.743 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.224225 | 0.649 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.127407 | 0.895 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.140289 | 0.853 |
| R-HSA-69481 | G2/M Checkpoints | 0.222049 | 0.654 |
| R-HSA-4839726 | Chromatin organization | 0.195919 | 0.708 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.061672 | 1.210 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.167160 | 0.777 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.204410 | 0.689 |
| R-HSA-9664420 | Killing mechanisms | 0.204410 | 0.689 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.080603 | 1.094 |
| R-HSA-9610379 | HCMV Late Events | 0.051634 | 1.287 |
| R-HSA-194138 | Signaling by VEGF | 0.077928 | 1.108 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.195256 | 0.709 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.191266 | 0.718 |
| R-HSA-168255 | Influenza Infection | 0.078197 | 1.107 |
| R-HSA-9707616 | Heme signaling | 0.190997 | 0.719 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.174018 | 0.759 |
| R-HSA-5693538 | Homology Directed Repair | 0.192725 | 0.715 |
| R-HSA-437239 | Recycling pathway of L1 | 0.131143 | 0.882 |
| R-HSA-425410 | Metal ion SLC transporters | 0.134988 | 0.870 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.076649 | 1.115 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.150607 | 0.822 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.066667 | 1.176 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.070763 | 1.150 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.070584 | 1.151 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.199247 | 0.701 |
| R-HSA-177929 | Signaling by EGFR | 0.166563 | 0.778 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.178714 | 0.748 |
| R-HSA-373760 | L1CAM interactions | 0.186983 | 0.728 |
| R-HSA-75153 | Apoptotic execution phase | 0.127325 | 0.895 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.127325 | 0.895 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.062837 | 1.202 |
| R-HSA-72306 | tRNA processing | 0.067062 | 1.174 |
| R-HSA-75893 | TNF signaling | 0.166563 | 0.778 |
| R-HSA-5619102 | SLC transporter disorders | 0.062418 | 1.205 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.191989 | 0.717 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.231255 | 0.636 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.231255 | 0.636 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.231255 | 0.636 |
| R-HSA-180292 | GAB1 signalosome | 0.231255 | 0.636 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.231255 | 0.636 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.232607 | 0.633 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.232607 | 0.633 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.232607 | 0.633 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.240002 | 0.620 |
| R-HSA-392517 | Rap1 signalling | 0.240002 | 0.620 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.240002 | 0.620 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.240002 | 0.620 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.241009 | 0.618 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.242200 | 0.616 |
| R-HSA-8852135 | Protein ubiquitination | 0.245215 | 0.610 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.248650 | 0.604 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.248650 | 0.604 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.248650 | 0.604 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.248650 | 0.604 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.248650 | 0.604 |
| R-HSA-1181150 | Signaling by NODAL | 0.248650 | 0.604 |
| R-HSA-445144 | Signal transduction by L1 | 0.248650 | 0.604 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.255241 | 0.593 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.257199 | 0.590 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.257199 | 0.590 |
| R-HSA-198753 | ERK/MAPK targets | 0.257199 | 0.590 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.257199 | 0.590 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.257199 | 0.590 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.257199 | 0.590 |
| R-HSA-216083 | Integrin cell surface interactions | 0.257850 | 0.589 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.265652 | 0.576 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.265652 | 0.576 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.265652 | 0.576 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.265652 | 0.576 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.265652 | 0.576 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.270494 | 0.568 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.270494 | 0.568 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.274010 | 0.562 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.274010 | 0.562 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.274010 | 0.562 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.274010 | 0.562 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.279505 | 0.554 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.282273 | 0.549 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.282273 | 0.549 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.282273 | 0.549 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.287343 | 0.542 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.287343 | 0.542 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.290442 | 0.537 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.290442 | 0.537 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.290442 | 0.537 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.292666 | 0.534 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.294870 | 0.530 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.295266 | 0.530 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.295754 | 0.529 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.298519 | 0.525 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-2160916 | Hyaluronan degradation | 0.298519 | 0.525 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.306504 | 0.514 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.306504 | 0.514 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.306504 | 0.514 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.306504 | 0.514 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.306504 | 0.514 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.306504 | 0.514 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.306504 | 0.514 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.310784 | 0.508 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.314399 | 0.503 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.314399 | 0.503 |
| R-HSA-913531 | Interferon Signaling | 0.316194 | 0.500 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.322205 | 0.492 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.322205 | 0.492 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.326329 | 0.486 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.329922 | 0.482 |
| R-HSA-180024 | DARPP-32 events | 0.329922 | 0.482 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.330715 | 0.481 |
| R-HSA-1474290 | Collagen formation | 0.333378 | 0.477 |
| R-HSA-1280218 | Adaptive Immune System | 0.335826 | 0.474 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.337551 | 0.472 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.337551 | 0.472 |
| R-HSA-9679506 | SARS-CoV Infections | 0.338067 | 0.471 |
| R-HSA-109581 | Apoptosis | 0.338766 | 0.470 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.345095 | 0.462 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.345095 | 0.462 |
| R-HSA-182971 | EGFR downregulation | 0.345095 | 0.462 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.345802 | 0.461 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.348458 | 0.458 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.349927 | 0.456 |
| R-HSA-157579 | Telomere Maintenance | 0.349927 | 0.456 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.358151 | 0.446 |
| R-HSA-354192 | Integrin signaling | 0.359926 | 0.444 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.359926 | 0.444 |
| R-HSA-9930044 | Nuclear RNA decay | 0.359926 | 0.444 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.359926 | 0.444 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.367216 | 0.435 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.367216 | 0.435 |
| R-HSA-1474244 | Extracellular matrix organization | 0.373265 | 0.428 |
| R-HSA-5673000 | RAF activation | 0.374423 | 0.427 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.374423 | 0.427 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.374423 | 0.427 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.374423 | 0.427 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.375954 | 0.425 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.375954 | 0.425 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.375954 | 0.425 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.381549 | 0.418 |
| R-HSA-381042 | PERK regulates gene expression | 0.381549 | 0.418 |
| R-HSA-9833110 | RSV-host interactions | 0.382586 | 0.417 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.387451 | 0.412 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.388594 | 0.411 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.388594 | 0.411 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.388594 | 0.411 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.388594 | 0.411 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.395559 | 0.403 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.395559 | 0.403 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.395559 | 0.403 |
| R-HSA-8948216 | Collagen chain trimerization | 0.395559 | 0.403 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.398081 | 0.400 |
| R-HSA-8875878 | MET promotes cell motility | 0.402445 | 0.395 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.402445 | 0.395 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.409254 | 0.388 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.409254 | 0.388 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.415985 | 0.381 |
| R-HSA-3371568 | Attenuation phase | 0.415985 | 0.381 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.422394 | 0.374 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.422639 | 0.374 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.422639 | 0.374 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.422639 | 0.374 |
| R-HSA-9694548 | Maturation of spike protein | 0.422639 | 0.374 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.422639 | 0.374 |
| R-HSA-5617833 | Cilium Assembly | 0.427848 | 0.369 |
| R-HSA-167161 | HIV Transcription Initiation | 0.429219 | 0.367 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.429219 | 0.367 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.429219 | 0.367 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.429219 | 0.367 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.429219 | 0.367 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.430858 | 0.366 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.434082 | 0.362 |
| R-HSA-165159 | MTOR signalling | 0.435724 | 0.361 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.439854 | 0.357 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.441804 | 0.355 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.442155 | 0.354 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.442155 | 0.354 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.445643 | 0.351 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.445822 | 0.351 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.448513 | 0.348 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.454799 | 0.342 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.454799 | 0.342 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.454799 | 0.342 |
| R-HSA-73886 | Chromosome Maintenance | 0.457073 | 0.340 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.457681 | 0.339 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.461014 | 0.336 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.461727 | 0.336 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.464618 | 0.333 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.466506 | 0.331 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.467158 | 0.331 |
| R-HSA-72172 | mRNA Splicing | 0.472355 | 0.326 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.473232 | 0.325 |
| R-HSA-5357801 | Programmed Cell Death | 0.475268 | 0.323 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.475819 | 0.323 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.475819 | 0.323 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.475819 | 0.323 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.479238 | 0.319 |
| R-HSA-9766229 | Degradation of CDH1 | 0.479238 | 0.319 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.486877 | 0.313 |
| R-HSA-112316 | Neuronal System | 0.487560 | 0.312 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.491046 | 0.309 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.494169 | 0.306 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.495452 | 0.305 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.496850 | 0.304 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.502588 | 0.299 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.502588 | 0.299 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.502588 | 0.299 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.502588 | 0.299 |
| R-HSA-9909396 | Circadian clock | 0.504984 | 0.297 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.504984 | 0.297 |
| R-HSA-72649 | Translation initiation complex formation | 0.508261 | 0.294 |
| R-HSA-418990 | Adherens junctions interactions | 0.512444 | 0.290 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.513869 | 0.289 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.519414 | 0.284 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.519414 | 0.284 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.519414 | 0.284 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.519414 | 0.284 |
| R-HSA-5578775 | Ion homeostasis | 0.519414 | 0.284 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.519414 | 0.284 |
| R-HSA-163685 | Integration of energy metabolism | 0.522675 | 0.282 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.524896 | 0.280 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.526162 | 0.279 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.530316 | 0.275 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.530316 | 0.275 |
| R-HSA-6807070 | PTEN Regulation | 0.533086 | 0.273 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.533086 | 0.273 |
| R-HSA-9033241 | Peroxisomal protein import | 0.535674 | 0.271 |
| R-HSA-186712 | Regulation of beta-cell development | 0.535674 | 0.271 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.540972 | 0.267 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.540972 | 0.267 |
| R-HSA-983189 | Kinesins | 0.540972 | 0.267 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.540972 | 0.267 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.540972 | 0.267 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.540972 | 0.267 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.546209 | 0.263 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.546209 | 0.263 |
| R-HSA-1442490 | Collagen degradation | 0.546209 | 0.263 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.551387 | 0.259 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.551387 | 0.259 |
| R-HSA-186797 | Signaling by PDGF | 0.551387 | 0.259 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.551387 | 0.259 |
| R-HSA-9824446 | Viral Infection Pathways | 0.554288 | 0.256 |
| R-HSA-373755 | Semaphorin interactions | 0.556506 | 0.255 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.556506 | 0.255 |
| R-HSA-8848021 | Signaling by PTK6 | 0.556506 | 0.255 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.556506 | 0.255 |
| R-HSA-8939211 | ESR-mediated signaling | 0.564180 | 0.249 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.566571 | 0.247 |
| R-HSA-166520 | Signaling by NTRKs | 0.566660 | 0.247 |
| R-HSA-9758941 | Gastrulation | 0.569921 | 0.244 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.581243 | 0.236 |
| R-HSA-167172 | Transcription of the HIV genome | 0.581243 | 0.236 |
| R-HSA-9609507 | Protein localization | 0.582788 | 0.234 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.590750 | 0.229 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.590750 | 0.229 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.590750 | 0.229 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.595422 | 0.225 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.595422 | 0.225 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.595422 | 0.225 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.595422 | 0.225 |
| R-HSA-3000178 | ECM proteoglycans | 0.595422 | 0.225 |
| R-HSA-421270 | Cell-cell junction organization | 0.600111 | 0.222 |
| R-HSA-4086398 | Ca2+ pathway | 0.604608 | 0.219 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.604623 | 0.219 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.609123 | 0.215 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.609123 | 0.215 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.609123 | 0.215 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.609123 | 0.215 |
| R-HSA-5688426 | Deubiquitination | 0.610016 | 0.215 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.613587 | 0.212 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.617999 | 0.209 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.622362 | 0.206 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.622362 | 0.206 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.630940 | 0.200 |
| R-HSA-6806834 | Signaling by MET | 0.635156 | 0.197 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.635156 | 0.197 |
| R-HSA-9833482 | PKR-mediated signaling | 0.635156 | 0.197 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.643444 | 0.191 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.647518 | 0.189 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.651545 | 0.186 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.651545 | 0.186 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.659463 | 0.181 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.663355 | 0.178 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.663355 | 0.178 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.667203 | 0.176 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.671006 | 0.173 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.672913 | 0.172 |
| R-HSA-73884 | Base Excision Repair | 0.678484 | 0.168 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.685794 | 0.164 |
| R-HSA-391251 | Protein folding | 0.689386 | 0.162 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.689386 | 0.162 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.692937 | 0.159 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.696449 | 0.157 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.699920 | 0.155 |
| R-HSA-195721 | Signaling by WNT | 0.705999 | 0.151 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.706744 | 0.151 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.706744 | 0.151 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.713414 | 0.147 |
| R-HSA-428157 | Sphingolipid metabolism | 0.717643 | 0.144 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.723137 | 0.141 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.726305 | 0.139 |
| R-HSA-1483255 | PI Metabolism | 0.726305 | 0.139 |
| R-HSA-111885 | Opioid Signalling | 0.732532 | 0.135 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.738618 | 0.132 |
| R-HSA-418346 | Platelet homeostasis | 0.741610 | 0.130 |
| R-HSA-397014 | Muscle contraction | 0.744536 | 0.128 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.747491 | 0.126 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.747491 | 0.126 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.747491 | 0.126 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.747491 | 0.126 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.747491 | 0.126 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.752973 | 0.123 |
| R-HSA-202403 | TCR signaling | 0.753239 | 0.123 |
| R-HSA-6803157 | Antimicrobial peptides | 0.756064 | 0.121 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.758856 | 0.120 |
| R-HSA-5663205 | Infectious disease | 0.763517 | 0.117 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.764347 | 0.117 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.767045 | 0.115 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.769713 | 0.114 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.774957 | 0.111 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.774957 | 0.111 |
| R-HSA-168249 | Innate Immune System | 0.777508 | 0.109 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.777535 | 0.109 |
| R-HSA-422475 | Axon guidance | 0.777643 | 0.109 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.778877 | 0.109 |
| R-HSA-199991 | Membrane Trafficking | 0.779797 | 0.108 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.782602 | 0.106 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.787555 | 0.104 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.792395 | 0.101 |
| R-HSA-168256 | Immune System | 0.803459 | 0.095 |
| R-HSA-114608 | Platelet degranulation | 0.804022 | 0.095 |
| R-HSA-73894 | DNA Repair | 0.811279 | 0.091 |
| R-HSA-597592 | Post-translational protein modification | 0.812079 | 0.090 |
| R-HSA-1266738 | Developmental Biology | 0.813931 | 0.089 |
| R-HSA-9843745 | Adipogenesis | 0.815000 | 0.089 |
| R-HSA-5576891 | Cardiac conduction | 0.815000 | 0.089 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.815457 | 0.089 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.817121 | 0.088 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.819218 | 0.087 |
| R-HSA-9675108 | Nervous system development | 0.821995 | 0.085 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.827370 | 0.082 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.835156 | 0.078 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.835156 | 0.078 |
| R-HSA-9664407 | Parasite infection | 0.835156 | 0.078 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.837047 | 0.077 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.842592 | 0.074 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.842802 | 0.074 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.856479 | 0.067 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.858127 | 0.066 |
| R-HSA-69306 | DNA Replication | 0.859756 | 0.066 |
| R-HSA-9658195 | Leishmania infection | 0.860089 | 0.065 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.860089 | 0.065 |
| R-HSA-1989781 | PPARA activates gene expression | 0.862958 | 0.064 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.866088 | 0.062 |
| R-HSA-9711097 | Cellular response to starvation | 0.867626 | 0.062 |
| R-HSA-1643685 | Disease | 0.882872 | 0.054 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.884323 | 0.053 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.886093 | 0.053 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.891242 | 0.050 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.892492 | 0.049 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.907506 | 0.042 |
| R-HSA-983712 | Ion channel transport | 0.908570 | 0.042 |
| R-HSA-6798695 | Neutrophil degranulation | 0.912502 | 0.040 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.912708 | 0.040 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.915812 | 0.038 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.922255 | 0.035 |
| R-HSA-72312 | rRNA processing | 0.945099 | 0.025 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.946527 | 0.024 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.950017 | 0.022 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.953289 | 0.021 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.961705 | 0.017 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.966305 | 0.015 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.969302 | 0.014 |
| R-HSA-1483257 | Phospholipid metabolism | 0.973616 | 0.012 |
| R-HSA-449147 | Signaling by Interleukins | 0.979626 | 0.009 |
| R-HSA-8957322 | Metabolism of steroids | 0.981189 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.982091 | 0.008 |
| R-HSA-392499 | Metabolism of proteins | 0.986701 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 0.990582 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 0.991281 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992964 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.992964 | 0.003 |
| R-HSA-72766 | Translation | 0.994566 | 0.002 |
| R-HSA-109582 | Hemostasis | 0.995428 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.999909 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.850 | 0.135 | 2 | 0.855 |
CDC7 |
0.846 | 0.155 | 1 | 0.852 |
MOS |
0.844 | 0.214 | 1 | 0.855 |
PIM3 |
0.843 | 0.188 | -3 | 0.930 |
CLK3 |
0.842 | 0.182 | 1 | 0.800 |
PRKD1 |
0.838 | 0.296 | -3 | 0.900 |
NDR2 |
0.837 | 0.107 | -3 | 0.926 |
CDKL1 |
0.836 | 0.223 | -3 | 0.894 |
MTOR |
0.835 | 0.046 | 1 | 0.738 |
CDKL5 |
0.834 | 0.222 | -3 | 0.887 |
SKMLCK |
0.834 | 0.159 | -2 | 0.819 |
CAMK1B |
0.834 | 0.191 | -3 | 0.921 |
RSK2 |
0.832 | 0.190 | -3 | 0.888 |
PIM1 |
0.831 | 0.207 | -3 | 0.905 |
PKN3 |
0.831 | 0.170 | -3 | 0.903 |
NUAK2 |
0.831 | 0.190 | -3 | 0.927 |
PRKD2 |
0.830 | 0.240 | -3 | 0.892 |
ATR |
0.830 | 0.068 | 1 | 0.795 |
PRPK |
0.829 | -0.074 | -1 | 0.830 |
ERK5 |
0.829 | 0.093 | 1 | 0.801 |
GRK1 |
0.829 | 0.109 | -2 | 0.788 |
SRPK1 |
0.829 | 0.173 | -3 | 0.870 |
MAPKAPK2 |
0.828 | 0.206 | -3 | 0.871 |
IKKB |
0.828 | -0.068 | -2 | 0.719 |
RAF1 |
0.828 | -0.026 | 1 | 0.788 |
P90RSK |
0.828 | 0.176 | -3 | 0.884 |
KIS |
0.827 | 0.073 | 1 | 0.654 |
PKN2 |
0.827 | 0.157 | -3 | 0.912 |
NLK |
0.827 | 0.056 | 1 | 0.777 |
HIPK4 |
0.826 | 0.141 | 1 | 0.730 |
CAMK2D |
0.826 | 0.150 | -3 | 0.905 |
CAMK2B |
0.825 | 0.175 | 2 | 0.736 |
PDHK4 |
0.825 | -0.130 | 1 | 0.791 |
CAMK2G |
0.825 | -0.020 | 2 | 0.768 |
CAMK2A |
0.825 | 0.199 | 2 | 0.753 |
DSTYK |
0.825 | -0.031 | 2 | 0.868 |
BMPR1B |
0.825 | 0.168 | 1 | 0.817 |
ICK |
0.824 | 0.174 | -3 | 0.914 |
DAPK2 |
0.824 | 0.148 | -3 | 0.919 |
RIPK3 |
0.823 | 0.018 | 3 | 0.717 |
LATS2 |
0.823 | 0.063 | -5 | 0.649 |
NDR1 |
0.823 | 0.052 | -3 | 0.924 |
WNK1 |
0.823 | 0.093 | -2 | 0.843 |
NIK |
0.823 | 0.112 | -3 | 0.919 |
RSK3 |
0.822 | 0.138 | -3 | 0.880 |
BMPR2 |
0.822 | -0.117 | -2 | 0.846 |
GRK5 |
0.822 | -0.052 | -3 | 0.840 |
MAPKAPK3 |
0.822 | 0.157 | -3 | 0.890 |
TBK1 |
0.821 | -0.095 | 1 | 0.670 |
CAMLCK |
0.820 | 0.073 | -2 | 0.785 |
GCN2 |
0.820 | -0.168 | 2 | 0.793 |
MARK4 |
0.820 | 0.042 | 4 | 0.784 |
GRK6 |
0.819 | 0.021 | 1 | 0.803 |
LATS1 |
0.819 | 0.146 | -3 | 0.927 |
GRK7 |
0.819 | 0.105 | 1 | 0.746 |
MST4 |
0.819 | 0.039 | 2 | 0.854 |
TSSK1 |
0.819 | 0.193 | -3 | 0.935 |
AMPKA1 |
0.819 | 0.105 | -3 | 0.928 |
IKKA |
0.819 | -0.039 | -2 | 0.724 |
SRPK2 |
0.818 | 0.157 | -3 | 0.816 |
FAM20C |
0.818 | 0.033 | 2 | 0.561 |
RSK4 |
0.818 | 0.159 | -3 | 0.872 |
TGFBR2 |
0.818 | -0.015 | -2 | 0.772 |
NUAK1 |
0.817 | 0.164 | -3 | 0.900 |
CDK18 |
0.817 | 0.108 | 1 | 0.590 |
CLK2 |
0.817 | 0.200 | -3 | 0.881 |
IKKE |
0.817 | -0.124 | 1 | 0.662 |
P70S6KB |
0.817 | 0.088 | -3 | 0.901 |
NEK6 |
0.817 | -0.063 | -2 | 0.841 |
TSSK2 |
0.816 | 0.174 | -5 | 0.820 |
MLK1 |
0.816 | -0.060 | 2 | 0.817 |
PDHK1 |
0.816 | -0.158 | 1 | 0.764 |
CHAK2 |
0.816 | -0.035 | -1 | 0.817 |
PKCD |
0.816 | 0.073 | 2 | 0.785 |
SRPK3 |
0.816 | 0.139 | -3 | 0.844 |
MASTL |
0.815 | -0.098 | -2 | 0.786 |
PKACG |
0.815 | 0.046 | -2 | 0.675 |
CDK1 |
0.815 | 0.074 | 1 | 0.619 |
DYRK2 |
0.815 | 0.102 | 1 | 0.662 |
MSK1 |
0.814 | 0.136 | -3 | 0.871 |
AURC |
0.814 | 0.058 | -2 | 0.583 |
CAMK4 |
0.814 | 0.091 | -3 | 0.906 |
AMPKA2 |
0.814 | 0.115 | -3 | 0.917 |
PASK |
0.814 | 0.240 | -3 | 0.926 |
PRKD3 |
0.813 | 0.223 | -3 | 0.864 |
HUNK |
0.813 | -0.093 | 2 | 0.795 |
DLK |
0.813 | -0.021 | 1 | 0.762 |
NEK7 |
0.813 | -0.145 | -3 | 0.822 |
ATM |
0.813 | 0.016 | 1 | 0.752 |
BCKDK |
0.812 | -0.107 | -1 | 0.802 |
ULK2 |
0.812 | -0.200 | 2 | 0.775 |
MSK2 |
0.812 | 0.098 | -3 | 0.867 |
CLK4 |
0.811 | 0.134 | -3 | 0.883 |
PKCB |
0.811 | 0.084 | 2 | 0.746 |
ANKRD3 |
0.811 | -0.030 | 1 | 0.792 |
QSK |
0.811 | 0.092 | 4 | 0.757 |
GRK4 |
0.811 | -0.085 | -2 | 0.819 |
CDK8 |
0.811 | 0.018 | 1 | 0.625 |
TGFBR1 |
0.810 | 0.058 | -2 | 0.797 |
JNK2 |
0.810 | 0.085 | 1 | 0.595 |
PKACB |
0.810 | 0.107 | -2 | 0.602 |
CLK1 |
0.810 | 0.151 | -3 | 0.866 |
ALK4 |
0.810 | 0.032 | -2 | 0.815 |
RIPK1 |
0.810 | -0.053 | 1 | 0.743 |
CHK1 |
0.809 | 0.198 | -3 | 0.900 |
MYLK4 |
0.809 | 0.098 | -2 | 0.700 |
PKCA |
0.809 | 0.078 | 2 | 0.741 |
ACVR2B |
0.809 | 0.067 | -2 | 0.773 |
MELK |
0.809 | 0.118 | -3 | 0.900 |
NIM1 |
0.808 | -0.010 | 3 | 0.728 |
MLK2 |
0.808 | -0.064 | 2 | 0.807 |
AKT2 |
0.808 | 0.158 | -3 | 0.832 |
JNK3 |
0.808 | 0.057 | 1 | 0.629 |
MLK3 |
0.808 | -0.010 | 2 | 0.749 |
CDK19 |
0.808 | 0.029 | 1 | 0.592 |
DRAK1 |
0.808 | 0.082 | 1 | 0.785 |
PHKG1 |
0.808 | 0.086 | -3 | 0.920 |
PRKX |
0.808 | 0.135 | -3 | 0.837 |
IRE1 |
0.808 | -0.038 | 1 | 0.723 |
HIPK2 |
0.807 | 0.121 | 1 | 0.580 |
PKCG |
0.807 | 0.042 | 2 | 0.746 |
SGK3 |
0.807 | 0.126 | -3 | 0.880 |
PLK1 |
0.806 | -0.032 | -2 | 0.769 |
CDK7 |
0.806 | 0.025 | 1 | 0.650 |
SIK |
0.806 | 0.108 | -3 | 0.878 |
CAMK1G |
0.806 | 0.143 | -3 | 0.875 |
PAK1 |
0.806 | 0.001 | -2 | 0.712 |
WNK3 |
0.806 | -0.171 | 1 | 0.741 |
P38B |
0.806 | 0.084 | 1 | 0.625 |
CDK5 |
0.806 | 0.048 | 1 | 0.671 |
P38A |
0.805 | 0.074 | 1 | 0.687 |
QIK |
0.805 | 0.033 | -3 | 0.895 |
PIM2 |
0.805 | 0.142 | -3 | 0.867 |
BMPR1A |
0.805 | 0.112 | 1 | 0.796 |
SMG1 |
0.805 | 0.002 | 1 | 0.748 |
ACVR2A |
0.805 | 0.035 | -2 | 0.756 |
DNAPK |
0.805 | 0.055 | 1 | 0.692 |
MNK2 |
0.805 | 0.038 | -2 | 0.719 |
DCAMKL1 |
0.804 | 0.134 | -3 | 0.903 |
CDK17 |
0.804 | 0.059 | 1 | 0.543 |
ALK2 |
0.804 | 0.051 | -2 | 0.806 |
NEK9 |
0.804 | -0.137 | 2 | 0.826 |
GRK2 |
0.804 | 0.016 | -2 | 0.721 |
PKR |
0.804 | -0.002 | 1 | 0.774 |
BRSK1 |
0.803 | 0.051 | -3 | 0.901 |
MARK3 |
0.803 | 0.048 | 4 | 0.711 |
HIPK1 |
0.803 | 0.117 | 1 | 0.672 |
PKCZ |
0.803 | 0.028 | 2 | 0.788 |
CDK14 |
0.803 | 0.100 | 1 | 0.625 |
TTBK2 |
0.803 | -0.153 | 2 | 0.690 |
MLK4 |
0.802 | -0.038 | 2 | 0.738 |
YSK4 |
0.802 | -0.056 | 1 | 0.706 |
DYRK1A |
0.802 | 0.129 | 1 | 0.690 |
MEK1 |
0.802 | -0.091 | 2 | 0.821 |
ERK1 |
0.802 | 0.046 | 1 | 0.612 |
ULK1 |
0.802 | -0.226 | -3 | 0.778 |
GSK3A |
0.801 | 0.105 | 4 | 0.483 |
CDK13 |
0.801 | 0.010 | 1 | 0.622 |
PKCH |
0.801 | 0.032 | 2 | 0.731 |
AURB |
0.801 | 0.018 | -2 | 0.582 |
MARK2 |
0.800 | 0.029 | 4 | 0.685 |
TLK2 |
0.800 | -0.047 | 1 | 0.728 |
DYRK4 |
0.800 | 0.098 | 1 | 0.599 |
MNK1 |
0.800 | 0.032 | -2 | 0.720 |
CK1E |
0.800 | 0.029 | -3 | 0.552 |
AURA |
0.800 | 0.021 | -2 | 0.561 |
VRK2 |
0.800 | -0.106 | 1 | 0.794 |
P38G |
0.800 | 0.046 | 1 | 0.533 |
GSK3B |
0.800 | 0.082 | 4 | 0.478 |
PAK3 |
0.799 | -0.050 | -2 | 0.703 |
PKG2 |
0.799 | 0.038 | -2 | 0.597 |
BRSK2 |
0.799 | 0.009 | -3 | 0.904 |
CDK3 |
0.799 | 0.052 | 1 | 0.564 |
CDK16 |
0.798 | 0.081 | 1 | 0.557 |
CDK2 |
0.798 | -0.007 | 1 | 0.691 |
DAPK3 |
0.797 | 0.140 | -3 | 0.912 |
DCAMKL2 |
0.797 | 0.102 | -3 | 0.909 |
MAPKAPK5 |
0.797 | 0.058 | -3 | 0.836 |
IRE2 |
0.797 | -0.075 | 2 | 0.757 |
CDK10 |
0.796 | 0.087 | 1 | 0.616 |
MAK |
0.796 | 0.213 | -2 | 0.723 |
CAMK1D |
0.796 | 0.177 | -3 | 0.836 |
P38D |
0.796 | 0.069 | 1 | 0.556 |
MST3 |
0.795 | 0.055 | 2 | 0.848 |
CDK12 |
0.795 | 0.017 | 1 | 0.594 |
CK2A2 |
0.795 | 0.067 | 1 | 0.758 |
GAK |
0.795 | 0.146 | 1 | 0.821 |
MARK1 |
0.795 | 0.014 | 4 | 0.726 |
PKACA |
0.795 | 0.095 | -2 | 0.546 |
DAPK1 |
0.794 | 0.140 | -3 | 0.897 |
PLK3 |
0.794 | -0.091 | 2 | 0.750 |
PAK2 |
0.794 | -0.060 | -2 | 0.694 |
SMMLCK |
0.794 | 0.077 | -3 | 0.899 |
HIPK3 |
0.793 | 0.088 | 1 | 0.660 |
ERK2 |
0.793 | -0.005 | 1 | 0.640 |
AKT1 |
0.793 | 0.119 | -3 | 0.850 |
MEKK3 |
0.793 | -0.087 | 1 | 0.735 |
CDK9 |
0.793 | -0.007 | 1 | 0.629 |
PAK6 |
0.793 | 0.006 | -2 | 0.615 |
CK1D |
0.792 | 0.031 | -3 | 0.503 |
GRK3 |
0.792 | 0.012 | -2 | 0.692 |
MPSK1 |
0.792 | 0.079 | 1 | 0.742 |
PLK4 |
0.791 | -0.086 | 2 | 0.634 |
SNRK |
0.791 | -0.106 | 2 | 0.697 |
CHK2 |
0.791 | 0.207 | -3 | 0.790 |
DYRK3 |
0.791 | 0.093 | 1 | 0.667 |
DYRK1B |
0.791 | 0.060 | 1 | 0.627 |
NEK5 |
0.790 | -0.055 | 1 | 0.768 |
JNK1 |
0.790 | 0.043 | 1 | 0.593 |
P70S6K |
0.790 | 0.073 | -3 | 0.834 |
NEK2 |
0.790 | -0.119 | 2 | 0.814 |
TAO3 |
0.790 | -0.007 | 1 | 0.730 |
PRP4 |
0.790 | 0.008 | -3 | 0.755 |
WNK4 |
0.789 | -0.014 | -2 | 0.844 |
BRAF |
0.789 | -0.097 | -4 | 0.813 |
MEK5 |
0.789 | -0.171 | 2 | 0.813 |
CHAK1 |
0.789 | -0.173 | 2 | 0.755 |
PKCT |
0.788 | 0.026 | 2 | 0.736 |
MEKK2 |
0.787 | -0.099 | 2 | 0.792 |
CAMK1A |
0.787 | 0.199 | -3 | 0.808 |
GCK |
0.787 | 0.064 | 1 | 0.752 |
ZAK |
0.787 | -0.120 | 1 | 0.690 |
CK1A2 |
0.787 | 0.017 | -3 | 0.508 |
TLK1 |
0.787 | -0.103 | -2 | 0.822 |
PKN1 |
0.786 | 0.148 | -3 | 0.848 |
PHKG2 |
0.786 | 0.039 | -3 | 0.890 |
PERK |
0.786 | -0.147 | -2 | 0.799 |
PKCE |
0.785 | 0.077 | 2 | 0.734 |
ERK7 |
0.785 | 0.083 | 2 | 0.620 |
CK2A1 |
0.785 | 0.058 | 1 | 0.738 |
NEK11 |
0.784 | -0.075 | 1 | 0.730 |
SGK1 |
0.784 | 0.146 | -3 | 0.772 |
IRAK4 |
0.784 | -0.096 | 1 | 0.721 |
CK1G1 |
0.784 | -0.038 | -3 | 0.550 |
SSTK |
0.784 | 0.002 | 4 | 0.745 |
AKT3 |
0.784 | 0.131 | -3 | 0.787 |
PKCI |
0.784 | 0.029 | 2 | 0.767 |
MEKK1 |
0.784 | -0.179 | 1 | 0.720 |
PDK1 |
0.783 | 0.015 | 1 | 0.750 |
HRI |
0.782 | -0.178 | -2 | 0.802 |
BUB1 |
0.782 | 0.236 | -5 | 0.846 |
MST2 |
0.781 | -0.040 | 1 | 0.749 |
SBK |
0.780 | 0.190 | -3 | 0.740 |
PINK1 |
0.780 | -0.194 | 1 | 0.767 |
MOK |
0.780 | 0.152 | 1 | 0.703 |
HPK1 |
0.780 | 0.047 | 1 | 0.734 |
NEK8 |
0.779 | -0.116 | 2 | 0.820 |
EEF2K |
0.779 | -0.008 | 3 | 0.767 |
PLK2 |
0.778 | -0.022 | -3 | 0.748 |
TAO2 |
0.777 | -0.075 | 2 | 0.831 |
TAK1 |
0.777 | -0.017 | 1 | 0.765 |
LKB1 |
0.776 | -0.106 | -3 | 0.838 |
LRRK2 |
0.776 | -0.043 | 2 | 0.844 |
MINK |
0.776 | -0.025 | 1 | 0.723 |
CDK6 |
0.775 | 0.018 | 1 | 0.604 |
TNIK |
0.775 | -0.011 | 3 | 0.771 |
MRCKA |
0.774 | 0.067 | -3 | 0.879 |
MEKK6 |
0.774 | -0.057 | 1 | 0.714 |
PAK5 |
0.774 | -0.037 | -2 | 0.560 |
MAP3K15 |
0.773 | -0.073 | 1 | 0.682 |
KHS2 |
0.773 | 0.054 | 1 | 0.734 |
HGK |
0.773 | -0.048 | 3 | 0.780 |
TTBK1 |
0.773 | -0.178 | 2 | 0.605 |
ROCK2 |
0.773 | 0.072 | -3 | 0.898 |
MRCKB |
0.773 | 0.069 | -3 | 0.863 |
PDHK3_TYR |
0.772 | 0.180 | 4 | 0.847 |
IRAK1 |
0.772 | -0.219 | -1 | 0.733 |
KHS1 |
0.772 | 0.024 | 1 | 0.715 |
DMPK1 |
0.771 | 0.122 | -3 | 0.885 |
VRK1 |
0.771 | -0.085 | 2 | 0.829 |
CAMKK1 |
0.771 | -0.214 | -2 | 0.717 |
PBK |
0.770 | 0.044 | 1 | 0.762 |
PAK4 |
0.770 | -0.038 | -2 | 0.569 |
CAMKK2 |
0.770 | -0.180 | -2 | 0.708 |
NEK4 |
0.770 | -0.131 | 1 | 0.716 |
CDK4 |
0.770 | 0.012 | 1 | 0.581 |
MST1 |
0.769 | -0.088 | 1 | 0.724 |
NEK1 |
0.768 | -0.079 | 1 | 0.726 |
PDHK4_TYR |
0.767 | 0.108 | 2 | 0.863 |
SLK |
0.767 | -0.072 | -2 | 0.658 |
MAP2K6_TYR |
0.765 | 0.074 | -1 | 0.858 |
LOK |
0.765 | -0.082 | -2 | 0.698 |
BMPR2_TYR |
0.765 | 0.109 | -1 | 0.869 |
CRIK |
0.764 | 0.114 | -3 | 0.846 |
MAP2K4_TYR |
0.764 | 0.052 | -1 | 0.845 |
TTK |
0.764 | -0.010 | -2 | 0.795 |
PDHK1_TYR |
0.762 | 0.056 | -1 | 0.860 |
YANK3 |
0.761 | -0.028 | 2 | 0.407 |
YSK1 |
0.761 | -0.070 | 2 | 0.810 |
TESK1_TYR |
0.761 | -0.045 | 3 | 0.813 |
STK33 |
0.760 | -0.168 | 2 | 0.613 |
CK1A |
0.759 | 0.003 | -3 | 0.416 |
RIPK2 |
0.758 | -0.208 | 1 | 0.662 |
OSR1 |
0.758 | -0.078 | 2 | 0.803 |
ROCK1 |
0.757 | 0.049 | -3 | 0.875 |
MAP2K7_TYR |
0.757 | -0.146 | 2 | 0.835 |
EPHA6 |
0.756 | 0.049 | -1 | 0.842 |
PKMYT1_TYR |
0.756 | -0.051 | 3 | 0.786 |
MEK2 |
0.756 | -0.261 | 2 | 0.791 |
PKG1 |
0.755 | 0.005 | -2 | 0.505 |
BIKE |
0.755 | 0.061 | 1 | 0.722 |
PINK1_TYR |
0.754 | -0.126 | 1 | 0.780 |
LIMK2_TYR |
0.753 | -0.013 | -3 | 0.902 |
FGR |
0.753 | 0.033 | 1 | 0.817 |
TXK |
0.753 | 0.090 | 1 | 0.825 |
EPHB4 |
0.753 | 0.010 | -1 | 0.808 |
HASPIN |
0.753 | -0.040 | -1 | 0.655 |
MYO3B |
0.751 | -0.044 | 2 | 0.823 |
FER |
0.748 | -0.047 | 1 | 0.839 |
NEK3 |
0.748 | -0.158 | 1 | 0.670 |
LCK |
0.748 | 0.066 | -1 | 0.827 |
BLK |
0.747 | 0.079 | -1 | 0.816 |
ALPHAK3 |
0.747 | -0.079 | -1 | 0.736 |
YES1 |
0.747 | -0.035 | -1 | 0.808 |
DDR1 |
0.747 | -0.113 | 4 | 0.778 |
EPHA4 |
0.746 | 0.004 | 2 | 0.758 |
RET |
0.746 | -0.137 | 1 | 0.720 |
TNK2 |
0.746 | 0.004 | 3 | 0.706 |
MYO3A |
0.746 | -0.093 | 1 | 0.697 |
HCK |
0.746 | 0.008 | -1 | 0.815 |
MST1R |
0.746 | -0.099 | 3 | 0.735 |
TYRO3 |
0.745 | -0.108 | 3 | 0.716 |
SRMS |
0.745 | -0.015 | 1 | 0.817 |
ASK1 |
0.744 | -0.169 | 1 | 0.668 |
ROS1 |
0.744 | -0.096 | 3 | 0.690 |
EPHB1 |
0.744 | -0.011 | 1 | 0.803 |
FYN |
0.744 | 0.083 | -1 | 0.810 |
INSRR |
0.744 | -0.058 | 3 | 0.699 |
LIMK1_TYR |
0.743 | -0.187 | 2 | 0.826 |
AAK1 |
0.743 | 0.106 | 1 | 0.636 |
ITK |
0.743 | -0.009 | -1 | 0.786 |
CSF1R |
0.742 | -0.103 | 3 | 0.711 |
TYK2 |
0.742 | -0.181 | 1 | 0.716 |
TAO1 |
0.741 | -0.111 | 1 | 0.642 |
EPHB3 |
0.741 | -0.026 | -1 | 0.796 |
ABL2 |
0.741 | -0.062 | -1 | 0.765 |
EPHB2 |
0.741 | -0.014 | -1 | 0.788 |
JAK3 |
0.740 | -0.100 | 1 | 0.711 |
PTK2 |
0.739 | 0.109 | -1 | 0.819 |
ABL1 |
0.739 | -0.061 | -1 | 0.756 |
KDR |
0.738 | -0.074 | 3 | 0.702 |
MERTK |
0.738 | -0.044 | 3 | 0.713 |
FGFR2 |
0.738 | -0.122 | 3 | 0.768 |
JAK2 |
0.737 | -0.183 | 1 | 0.708 |
BMX |
0.737 | -0.016 | -1 | 0.689 |
EPHA7 |
0.736 | -0.022 | 2 | 0.759 |
KIT |
0.736 | -0.123 | 3 | 0.730 |
EPHA3 |
0.735 | -0.057 | 2 | 0.733 |
TEC |
0.734 | -0.061 | -1 | 0.688 |
PDGFRB |
0.734 | -0.165 | 3 | 0.732 |
FLT3 |
0.733 | -0.138 | 3 | 0.716 |
MET |
0.733 | -0.091 | 3 | 0.717 |
AXL |
0.733 | -0.105 | 3 | 0.718 |
FLT1 |
0.733 | -0.073 | -1 | 0.825 |
STLK3 |
0.732 | -0.213 | 1 | 0.657 |
TNK1 |
0.732 | -0.100 | 3 | 0.701 |
TEK |
0.732 | -0.145 | 3 | 0.683 |
EPHA5 |
0.732 | -0.020 | 2 | 0.744 |
BTK |
0.731 | -0.148 | -1 | 0.742 |
SYK |
0.731 | 0.071 | -1 | 0.782 |
LYN |
0.731 | -0.042 | 3 | 0.654 |
FGFR3 |
0.730 | -0.122 | 3 | 0.744 |
SRC |
0.730 | -0.020 | -1 | 0.784 |
TNNI3K_TYR |
0.730 | -0.069 | 1 | 0.712 |
FRK |
0.729 | -0.063 | -1 | 0.805 |
PTK2B |
0.729 | -0.029 | -1 | 0.727 |
CK1G3 |
0.729 | -0.037 | -3 | 0.372 |
WEE1_TYR |
0.729 | -0.094 | -1 | 0.721 |
JAK1 |
0.729 | -0.085 | 1 | 0.660 |
EPHA1 |
0.729 | -0.075 | 3 | 0.702 |
ERBB2 |
0.729 | -0.127 | 1 | 0.696 |
FGFR1 |
0.728 | -0.175 | 3 | 0.711 |
PTK6 |
0.728 | -0.163 | -1 | 0.706 |
NEK10_TYR |
0.728 | -0.138 | 1 | 0.608 |
EPHA8 |
0.728 | -0.037 | -1 | 0.789 |
LTK |
0.728 | -0.124 | 3 | 0.680 |
DDR2 |
0.728 | -0.046 | 3 | 0.701 |
YANK2 |
0.728 | -0.061 | 2 | 0.414 |
ALK |
0.728 | -0.135 | 3 | 0.653 |
NTRK1 |
0.728 | -0.175 | -1 | 0.789 |
PDGFRA |
0.727 | -0.190 | 3 | 0.721 |
FLT4 |
0.724 | -0.161 | 3 | 0.709 |
INSR |
0.724 | -0.145 | 3 | 0.670 |
NTRK3 |
0.723 | -0.130 | -1 | 0.741 |
CK1G2 |
0.722 | -0.009 | -3 | 0.468 |
NTRK2 |
0.721 | -0.200 | 3 | 0.692 |
EGFR |
0.720 | -0.088 | 1 | 0.601 |
MATK |
0.718 | -0.140 | -1 | 0.680 |
EPHA2 |
0.717 | -0.045 | -1 | 0.762 |
CSK |
0.716 | -0.144 | 2 | 0.758 |
ERBB4 |
0.716 | -0.033 | 1 | 0.639 |
FGFR4 |
0.714 | -0.124 | -1 | 0.729 |
IGF1R |
0.713 | -0.128 | 3 | 0.626 |
FES |
0.705 | -0.098 | -1 | 0.663 |
MUSK |
0.705 | -0.152 | 1 | 0.603 |
ZAP70 |
0.702 | -0.034 | -1 | 0.702 |