Motif 50 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYK5 | None | S218 | ochoa | Uncharacterized protein | None |
| A0A1W2PP11 | None | S376 | ochoa | Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) | None |
| A1L390 | PLEKHG3 | S962 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NJZ7 | RIMBP3C | S1228 | ochoa | RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A6NNM3 | RIMBP3B | S1228 | ochoa | RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| K7ENP7 | None | S26 | ochoa | INO80 complex subunit C | None |
| O15014 | ZNF609 | S358 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O43156 | TTI1 | S459 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43166 | SIPA1L1 | S193 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O60333 | KIF1B | S893 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60861 | GAS7 | S111 | ochoa | Growth arrest-specific protein 7 (GAS-7) | May play a role in promoting maturation and morphological differentiation of cerebellar neurons. |
| O75128 | COBL | S815 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75143 | ATG13 | S361 | ochoa | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75369 | FLNB | S2083 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1472 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75382 | TRIM3 | S437 | ochoa | Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}. |
| O75781 | PALM | S162 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O94826 | TOMM70 | S91 | ochoa | Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). {ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:32728199, ECO:0000269|PubMed:35025629}. |
| O94929 | ABLIM3 | S373 | ochoa | Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| O94979 | SEC31A | S188 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95785 | WIZ | S968 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P02730 | SLC4A1 | S350 | ochoa | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P07203 | GPX1 | S153 | ochoa | Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402). {ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:36608588}. |
| P15884 | TCF4 | S198 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P21333 | FLNA | S2128 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23258 | TUBG1 | S284 | ochoa | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P27816 | MAP4 | S787 | ochoa|psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29475 | NOS1 | S292 | ochoa | Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1) | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. {ECO:0000269|PubMed:35772285}. |
| P35611 | ADD1 | S431 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P41212 | ETV6 | S323 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P42684 | ABL2 | S275 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P48169 | GABRA4 | S474 | psp | Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:35355020). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:35355020). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:35355020). {ECO:0000250|UniProtKB:Q9D6F4, ECO:0000269|PubMed:35355020}. |
| P49116 | NR2C2 | S19 | ochoa | Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
| P49146 | NPY2R | S251 | ochoa | Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. |
| P50747 | HLCS | S299 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P55210 | CASP7 | S234 | ochoa | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:15314233, PubMed:17697120, PubMed:19581639, PubMed:20566630, PubMed:23650375, PubMed:23897474, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:27889207, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}. |
| Q00653 | NFKB2 | S222 | ochoa|psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01970 | PLCB3 | S474 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q03468 | ERCC6 | S158 | ochoa|psp | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q12769 | NUP160 | S349 | ochoa | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport. {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}. |
| Q13098 | GPS1 | S468 | ochoa|psp | COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q13363 | CTBP1 | S422 | psp | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
| Q14137 | BOP1 | S573 | ochoa | Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. |
| Q14687 | GSE1 | S850 | ochoa | Genetic suppressor element 1 | None |
| Q15742 | NAB2 | S147 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15853 | USF2 | S155 | psp | Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2) | Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. |
| Q15911 | ZFHX3 | S2625 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q32MK0 | MYLK3 | S408 | ochoa | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q52LD8 | RFTN2 | S453 | ochoa | Raftlin-2 (Raft-linking protein 2) | Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}. |
| Q52LR7 | EPC2 | S688 | ochoa | Enhancer of polycomb homolog 2 (EPC-like) | May play a role in transcription or DNA repair. {ECO:0000250}. |
| Q58EX2 | SDK2 | S2019 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5FBB7 | SGO1 | S507 | psp | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5SXM2 | SNAPC4 | S702 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5VU43 | PDE4DIP | S1156 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VWQ8 | DAB2IP | S957 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q5VYS8 | TUT7 | S960 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q676U5 | ATG16L1 | S70 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q68CJ9 | CREB3L3 | S395 | psp | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704, ECO:0000269|PubMed:21666694}. |
| Q6GYQ0 | RALGAPA1 | S740 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6IE81 | JADE1 | S703 | ochoa | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
| Q6IQ26 | DENND5A | S52 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Q6P0N0 | MIS18BP1 | S1042 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P995 | FAM171B | S779 | ochoa | Protein FAM171B | None |
| Q6PGQ7 | BORA | S183 | ochoa | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6PI98 | INO80C | S26 | ochoa | INO80 complex subunit C (IES6 homolog) (hIes6) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q6W2J9 | BCOR | S294 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q7L3V2 | RTL10 | S34 | ochoa | Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) | Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}. |
| Q7Z2K8 | GPRIN1 | S452 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z589 | EMSY | S1213 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q7Z5L9 | IRF2BP2 | S457 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q86U44 | METTL3 | S525 | psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86YN6 | PPARGC1B | S384 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q8IVD9 | NUDCD3 | S340 | ochoa | NudC domain-containing protein 3 | None |
| Q8IWT3 | CUL9 | S976 | ochoa | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (PubMed:38605244). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (PubMed:12526791, PubMed:17332328). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (PubMed:38605244). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (PubMed:38605244). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:38605244}. |
| Q8N108 | MIER1 | S488 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8N201 | INTS1 | S1327 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q8N5D0 | WDTC1 | S227 | ochoa | WD and tetratricopeptide repeats protein 1 | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16964240}. |
| Q8N612 | FHIP1B | S467 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8NB78 | KDM1B | S247 | ochoa | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244). {ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23357850, ECO:0000269|PubMed:30970244}. |
| Q8NBT0 | POC1A | S70 | ochoa | POC1 centriolar protein homolog A (Pix2) (Proteome of centriole protein 1A) (WD repeat-containing protein 51A) | Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation. {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:23015594}. |
| Q8NC26 | ZNF114 | S118 | ochoa | Zinc finger protein 114 | May be involved in transcriptional regulation. |
| Q8NCD3 | HJURP | S473 | ochoa|psp | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NDT2 | RBM15B | S147 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
| Q8NFH5 | NUP35 | S100 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8WWQ0 | PHIP | S1560 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WX93 | PALLD | S1101 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q92917 | GPKOW | S20 | ochoa | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q96A26 | FAM162A | S47 | ochoa | Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P) | Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). {ECO:0000250|UniProtKB:Q9D6U8, ECO:0000269|PubMed:15082785}. |
| Q96BD0 | SLCO4A1 | S34 | ochoa | Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) | Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}. |
| Q96FS4 | SIPA1 | S817 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96QT6 | PHF12 | S769 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96RL1 | UIMC1 | S463 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99708 | RBBP8 | S549 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q9BT81 | SOX7 | S166 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
| Q9C0I3 | CCSER1 | S448 | ochoa | Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) | None |
| Q9H0E3 | SAP130 | S442 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H0H5 | RACGAP1 | S274 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H2X6 | HIPK2 | S668 | psp | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H9H5 | MAP6D1 | S167 | ochoa | MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21) | May have microtubule-stabilizing activity. {ECO:0000250}. |
| Q9HB07 | MYG1 | S120 | ochoa | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
| Q9HB58 | SP110 | S380 | ochoa | Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) | Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). |
| Q9NRH3 | TUBG2 | S284 | ochoa | Tubulin gamma-2 chain (Gamma-2-tubulin) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685). {ECO:0000269|PubMed:38305685}. |
| Q9NSY0 | NRBP2 | S209 | ochoa | Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16) | May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}. |
| Q9NWH9 | SLTM | S800 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9UFD9 | RIMBP3 | S1228 | ochoa | RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| Q9UHB7 | AFF4 | S549 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UJF2 | RASAL2 | S35 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKA4 | AKAP11 | S456 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKA4 | AKAP11 | S1580 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9ULD9 | ZNF608 | S421 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULI3 | HEG1 | S1332 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
| Q9UPN9 | TRIM33 | S644 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UPN9 | TRIM33 | S862 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UQ26 | RIMS2 | S470 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9Y230 | RUVBL2 | S342 | ochoa | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| Q9Y2U8 | LEMD3 | S149 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2U8 | LEMD3 | S180 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y4E6 | WDR7 | S1456 | ochoa | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | None |
| Q9Y4X4 | KLF12 | S202 | ochoa | Krueppel-like factor 12 (Transcriptional repressor AP-2rep) | Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. |
| Q9Y597 | KCTD3 | S791 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q5R3I4 | TTC38 | S362 | Sugiyama | Tetratricopeptide repeat protein 38 (TPR repeat protein 38) | None |
| Q9UHL4 | DPP7 | S213 | Sugiyama | Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) | Plays an important role in the degradation of some oligopeptides. {ECO:0000269|PubMed:15487984}. |
| P30260 | CDC27 | S312 | EPSD|PSP | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P07814 | EPRS1 | S1350 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.000295 | 3.530 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.000325 | 3.488 |
| R-HSA-1640170 | Cell Cycle | 0.000987 | 3.006 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.016262 | 1.789 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.016262 | 1.789 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.016262 | 1.789 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.016262 | 1.789 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.016262 | 1.789 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.024294 | 1.615 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.055777 | 1.254 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.063489 | 1.197 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.063489 | 1.197 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.078726 | 1.104 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.078726 | 1.104 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.078726 | 1.104 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.078726 | 1.104 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.130143 | 0.886 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.035680 | 1.448 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.137252 | 0.862 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.037492 | 1.426 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.037492 | 1.426 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.041220 | 1.385 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.041220 | 1.385 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.043134 | 1.365 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.151297 | 0.820 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.151297 | 0.820 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.047059 | 1.327 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.165116 | 0.782 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.055281 | 1.257 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.171941 | 0.765 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.171941 | 0.765 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.057411 | 1.241 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.178711 | 0.748 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.178711 | 0.748 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.185426 | 0.732 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.185426 | 0.732 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.185426 | 0.732 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.185426 | 0.732 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.192086 | 0.717 |
| R-HSA-774815 | Nucleosome assembly | 0.070758 | 1.150 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.070758 | 1.150 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.198693 | 0.702 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.205246 | 0.688 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.224587 | 0.649 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.097466 | 1.011 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.102590 | 0.989 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.102590 | 0.989 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.237220 | 0.625 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.249650 | 0.603 |
| R-HSA-390522 | Striated Muscle Contraction | 0.279851 | 0.553 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.143093 | 0.844 |
| R-HSA-380287 | Centrosome maturation | 0.148725 | 0.828 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.157255 | 0.803 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.180418 | 0.744 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.180418 | 0.744 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.189235 | 0.723 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.165875 | 0.780 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.168767 | 0.773 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.183350 | 0.737 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.031397 | 1.503 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.144303 | 0.841 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.143093 | 0.844 |
| R-HSA-5693538 | Homology Directed Repair | 0.095240 | 1.021 |
| R-HSA-4641265 | Repression of WNT target genes | 0.007835 | 2.106 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.073073 | 1.136 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.063866 | 1.195 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.085718 | 1.067 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.093717 | 1.028 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.165116 | 0.782 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.273909 | 0.562 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.285745 | 0.544 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.174577 | 0.758 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.100479 | 0.998 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.192086 | 0.717 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.188393 | 0.725 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.279851 | 0.553 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.230929 | 0.637 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.028792 | 1.541 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.039339 | 1.405 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.273909 | 0.562 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.285745 | 0.544 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.126496 | 0.898 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.016163 | 1.791 |
| R-HSA-373756 | SDK interactions | 0.016262 | 1.789 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.063489 | 1.197 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.144303 | 0.841 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.158235 | 0.801 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.051110 | 1.291 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.171941 | 0.765 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.070758 | 1.150 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.205246 | 0.688 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.218192 | 0.661 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.218192 | 0.661 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.285745 | 0.544 |
| R-HSA-73886 | Chromosome Maintenance | 0.005322 | 2.274 |
| R-HSA-69190 | DNA strand elongation | 0.267918 | 0.572 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.255789 | 0.592 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.166142 | 0.780 |
| R-HSA-157579 | Telomere Maintenance | 0.059851 | 1.223 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.043134 | 1.365 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.082569 | 1.083 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.273909 | 0.562 |
| R-HSA-196780 | Biotin transport and metabolism | 0.144303 | 0.841 |
| R-HSA-68882 | Mitotic Anaphase | 0.045656 | 1.341 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.178711 | 0.748 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.046339 | 1.334 |
| R-HSA-180786 | Extension of Telomeres | 0.105179 | 0.978 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.055777 | 1.254 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.063489 | 1.197 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.115750 | 0.936 |
| R-HSA-2142712 | Synthesis of 12-eicosatetraenoic acid derivatives | 0.144303 | 0.841 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.151297 | 0.820 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.158235 | 0.801 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.105179 | 0.978 |
| R-HSA-191859 | snRNP Assembly | 0.105179 | 0.978 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.110411 | 0.957 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.255789 | 0.592 |
| R-HSA-68877 | Mitotic Prometaphase | 0.097635 | 1.010 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.230929 | 0.637 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.016752 | 1.776 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.255789 | 0.592 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.004502 | 2.347 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.063489 | 1.197 |
| R-HSA-69239 | Synthesis of DNA | 0.255183 | 0.593 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.036348 | 1.440 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.005880 | 2.231 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.045081 | 1.346 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.158235 | 0.801 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.291591 | 0.535 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.077775 | 1.109 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.055777 | 1.254 |
| R-HSA-425381 | Bicarbonate transporters | 0.108465 | 0.965 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.122976 | 0.910 |
| R-HSA-69091 | Polymerase switching | 0.122976 | 0.910 |
| R-HSA-69109 | Leading Strand Synthesis | 0.122976 | 0.910 |
| R-HSA-2142770 | Synthesis of 15-eicosatetraenoic acid derivatives | 0.165116 | 0.782 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.057411 | 1.241 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.057411 | 1.241 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.059568 | 1.225 |
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | 0.178711 | 0.748 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.211745 | 0.674 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.218192 | 0.661 |
| R-HSA-429947 | Deadenylation of mRNA | 0.218192 | 0.661 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.040580 | 1.392 |
| R-HSA-9839394 | TGFBR3 expression | 0.224587 | 0.649 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.145903 | 0.836 |
| R-HSA-68886 | M Phase | 0.048937 | 1.310 |
| R-HSA-9609690 | HCMV Early Events | 0.258902 | 0.587 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.085466 | 1.068 |
| R-HSA-73894 | DNA Repair | 0.093497 | 1.029 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.059568 | 1.225 |
| R-HSA-69275 | G2/M Transition | 0.007148 | 2.146 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.007478 | 2.126 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.249650 | 0.603 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.165875 | 0.780 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.134736 | 0.871 |
| R-HSA-983189 | Kinesins | 0.107787 | 0.967 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.009208 | 2.036 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.140295 | 0.853 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.055777 | 1.254 |
| R-HSA-448706 | Interleukin-1 processing | 0.093717 | 1.028 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.122976 | 0.910 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.122976 | 0.910 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.122976 | 0.910 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.043134 | 1.365 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.053181 | 1.274 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.073073 | 1.136 |
| R-HSA-3214847 | HATs acetylate histones | 0.062514 | 1.204 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.140295 | 0.853 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.291591 | 0.535 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.261235 | 0.583 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.291489 | 0.535 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.071139 | 1.148 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.285745 | 0.544 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.039339 | 1.405 |
| R-HSA-4086398 | Ca2+ pathway | 0.143093 | 0.844 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.039339 | 1.405 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.171941 | 0.765 |
| R-HSA-5689603 | UCH proteinases | 0.151558 | 0.819 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.219000 | 0.660 |
| R-HSA-195721 | Signaling by WNT | 0.121545 | 0.915 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.122976 | 0.910 |
| R-HSA-5578768 | Physiological factors | 0.137252 | 0.862 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.158235 | 0.801 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.055281 | 1.257 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.171941 | 0.765 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.224587 | 0.649 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.230929 | 0.637 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.243460 | 0.614 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.123777 | 0.907 |
| R-HSA-1632852 | Macroautophagy | 0.140972 | 0.851 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.185426 | 0.732 |
| R-HSA-397014 | Muscle contraction | 0.296556 | 0.528 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.198693 | 0.702 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.222001 | 0.654 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.041220 | 1.385 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.171941 | 0.765 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.178711 | 0.748 |
| R-HSA-392517 | Rap1 signalling | 0.178711 | 0.748 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.198693 | 0.702 |
| R-HSA-525793 | Myogenesis | 0.230929 | 0.637 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.113052 | 0.947 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.249650 | 0.603 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.082640 | 1.083 |
| R-HSA-9612973 | Autophagy | 0.172131 | 0.764 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.273909 | 0.562 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.079566 | 1.099 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.178711 | 0.748 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.031397 | 1.503 |
| R-HSA-75153 | Apoptotic execution phase | 0.073073 | 1.136 |
| R-HSA-3214842 | HDMs demethylate histones | 0.224587 | 0.649 |
| R-HSA-68875 | Mitotic Prophase | 0.098507 | 1.007 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.183350 | 0.737 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.093717 | 1.028 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.137252 | 0.862 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.165116 | 0.782 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.211745 | 0.674 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.279851 | 0.553 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.144303 | 0.841 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.165116 | 0.782 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.102590 | 0.989 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.243460 | 0.614 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.154401 | 0.811 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.097466 | 1.011 |
| R-HSA-74160 | Gene expression (Transcription) | 0.196746 | 0.706 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.103491 | 0.985 |
| R-HSA-70171 | Glycolysis | 0.231023 | 0.636 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.144756 | 0.839 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.115750 | 0.936 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.144303 | 0.841 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.151297 | 0.820 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.198693 | 0.702 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.273909 | 0.562 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.018777 | 1.726 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.028792 | 1.541 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.213009 | 0.672 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.279851 | 0.553 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.237052 | 0.625 |
| R-HSA-8983711 | OAS antiviral response | 0.122976 | 0.910 |
| R-HSA-4839726 | Chromatin organization | 0.024031 | 1.619 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.039339 | 1.405 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.243460 | 0.614 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.267711 | 0.572 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.055281 | 1.257 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.009582 | 2.019 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.019619 | 1.707 |
| R-HSA-5358508 | Mismatch Repair | 0.171941 | 0.765 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.178711 | 0.748 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.009583 | 2.018 |
| R-HSA-5688426 | Deubiquitination | 0.190117 | 0.721 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.222001 | 0.654 |
| R-HSA-70326 | Glucose metabolism | 0.291489 | 0.535 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.180211 | 0.744 |
| R-HSA-5205647 | Mitophagy | 0.285745 | 0.544 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.008052 | 2.094 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.053876 | 1.269 |
| R-HSA-913531 | Interferon Signaling | 0.115922 | 0.936 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.009911 | 2.004 |
| R-HSA-622312 | Inflammasomes | 0.243460 | 0.614 |
| R-HSA-72306 | tRNA processing | 0.202936 | 0.693 |
| R-HSA-5619102 | SLC transporter disorders | 0.194592 | 0.711 |
| R-HSA-211000 | Gene Silencing by RNA | 0.255183 | 0.593 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.297389 | 0.527 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.297389 | 0.527 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.297389 | 0.527 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.303559 | 0.518 |
| R-HSA-3371556 | Cellular response to heat stress | 0.303559 | 0.518 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.308845 | 0.510 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.308845 | 0.510 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.309581 | 0.509 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.310192 | 0.508 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.312588 | 0.505 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.314504 | 0.502 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.314504 | 0.502 |
| R-HSA-8951664 | Neddylation | 0.316646 | 0.499 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.318595 | 0.497 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.318595 | 0.497 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.318595 | 0.497 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.320116 | 0.495 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.320116 | 0.495 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.320116 | 0.495 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.320116 | 0.495 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.320116 | 0.495 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.320116 | 0.495 |
| R-HSA-5260271 | Diseases of Immune System | 0.320116 | 0.495 |
| R-HSA-69481 | G2/M Checkpoints | 0.324589 | 0.489 |
| R-HSA-114608 | Platelet degranulation | 0.324589 | 0.489 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.325683 | 0.487 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.325683 | 0.487 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.325683 | 0.487 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.325683 | 0.487 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.325683 | 0.487 |
| R-HSA-9607240 | FLT3 Signaling | 0.325683 | 0.487 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.327581 | 0.485 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.330891 | 0.480 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.331204 | 0.480 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.332295 | 0.478 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.336681 | 0.473 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.336681 | 0.473 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.336681 | 0.473 |
| R-HSA-9843745 | Adipogenesis | 0.339515 | 0.469 |
| R-HSA-5576891 | Cardiac conduction | 0.339515 | 0.469 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.342488 | 0.465 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.345458 | 0.462 |
| R-HSA-2262752 | Cellular responses to stress | 0.347045 | 0.460 |
| R-HSA-373752 | Netrin-1 signaling | 0.347501 | 0.459 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.352845 | 0.452 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.357292 | 0.447 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.358146 | 0.446 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.358146 | 0.446 |
| R-HSA-9675135 | Diseases of DNA repair | 0.358146 | 0.446 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.358146 | 0.446 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.358146 | 0.446 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.358146 | 0.446 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.363404 | 0.440 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.363404 | 0.440 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.363404 | 0.440 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.368618 | 0.433 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.368618 | 0.433 |
| R-HSA-73893 | DNA Damage Bypass | 0.373791 | 0.427 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.373791 | 0.427 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.374663 | 0.426 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.377814 | 0.423 |
| R-HSA-9609646 | HCMV Infection | 0.381317 | 0.419 |
| R-HSA-912446 | Meiotic recombination | 0.384010 | 0.416 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.389057 | 0.410 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.389057 | 0.410 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.389057 | 0.410 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.389057 | 0.410 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.394064 | 0.404 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.394064 | 0.404 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.394064 | 0.404 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.394064 | 0.404 |
| R-HSA-69242 | S Phase | 0.395190 | 0.403 |
| R-HSA-166520 | Signaling by NTRKs | 0.395190 | 0.403 |
| R-HSA-9758941 | Gastrulation | 0.398065 | 0.400 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.399029 | 0.399 |
| R-HSA-8953854 | Metabolism of RNA | 0.403826 | 0.394 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.403955 | 0.394 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.403955 | 0.394 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.408840 | 0.388 |
| R-HSA-5578775 | Ion homeostasis | 0.408840 | 0.388 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.408840 | 0.388 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.408840 | 0.388 |
| R-HSA-69306 | DNA Replication | 0.409502 | 0.388 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.412345 | 0.385 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.415182 | 0.382 |
| R-HSA-1989781 | PPARA activates gene expression | 0.415182 | 0.382 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.420834 | 0.376 |
| R-HSA-9610379 | HCMV Late Events | 0.420834 | 0.376 |
| R-HSA-162587 | HIV Life Cycle | 0.420834 | 0.376 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.423258 | 0.373 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.423258 | 0.373 |
| R-HSA-877300 | Interferon gamma signaling | 0.426459 | 0.370 |
| R-HSA-379724 | tRNA Aminoacylation | 0.427986 | 0.369 |
| R-HSA-977443 | GABA receptor activation | 0.427986 | 0.369 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.427986 | 0.369 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.427986 | 0.369 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.427986 | 0.369 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.427986 | 0.369 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.427986 | 0.369 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.427986 | 0.369 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.429261 | 0.367 |
| R-HSA-112043 | PLC beta mediated events | 0.432676 | 0.364 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.432676 | 0.364 |
| R-HSA-109581 | Apoptosis | 0.434843 | 0.362 |
| R-HSA-9707616 | Heme signaling | 0.437327 | 0.359 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.437327 | 0.359 |
| R-HSA-1268020 | Mitochondrial protein import | 0.437327 | 0.359 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.441941 | 0.355 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.441941 | 0.355 |
| R-HSA-446728 | Cell junction organization | 0.442497 | 0.354 |
| R-HSA-162582 | Signal Transduction | 0.446199 | 0.350 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.446517 | 0.350 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.448883 | 0.348 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.455558 | 0.341 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.455558 | 0.341 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.460023 | 0.337 |
| R-HSA-112040 | G-protein mediated events | 0.460023 | 0.337 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.465013 | 0.333 |
| R-HSA-199991 | Membrane Trafficking | 0.470084 | 0.328 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.473077 | 0.325 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.473202 | 0.325 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.473202 | 0.325 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.473202 | 0.325 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.477523 | 0.321 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.477523 | 0.321 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.477523 | 0.321 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.477523 | 0.321 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.477523 | 0.321 |
| R-HSA-168255 | Influenza Infection | 0.483717 | 0.315 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.486061 | 0.313 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.488407 | 0.311 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.490278 | 0.310 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.490278 | 0.310 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.490278 | 0.310 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.498609 | 0.302 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.498609 | 0.302 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.506805 | 0.295 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.506805 | 0.295 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.514868 | 0.288 |
| R-HSA-1500931 | Cell-Cell communication | 0.521495 | 0.283 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.522420 | 0.282 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.522800 | 0.282 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.526718 | 0.278 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.526718 | 0.278 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.529466 | 0.276 |
| R-HSA-212436 | Generic Transcription Pathway | 0.530346 | 0.275 |
| R-HSA-1500620 | Meiosis | 0.534458 | 0.272 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.534458 | 0.272 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.537355 | 0.270 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.538280 | 0.269 |
| R-HSA-72172 | mRNA Splicing | 0.549556 | 0.260 |
| R-HSA-9663891 | Selective autophagy | 0.549562 | 0.260 |
| R-HSA-5357801 | Programmed Cell Death | 0.551969 | 0.258 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.556931 | 0.254 |
| R-HSA-73884 | Base Excision Repair | 0.556931 | 0.254 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.567761 | 0.246 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.568608 | 0.245 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.570949 | 0.243 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.571312 | 0.243 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.584979 | 0.233 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.585230 | 0.233 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.585230 | 0.233 |
| R-HSA-422356 | Regulation of insulin secretion | 0.592019 | 0.228 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.592019 | 0.228 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.592019 | 0.228 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.592019 | 0.228 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.601998 | 0.220 |
| R-HSA-162906 | HIV Infection | 0.602760 | 0.220 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.610264 | 0.214 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.611734 | 0.213 |
| R-HSA-111885 | Opioid Signalling | 0.611734 | 0.213 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.614926 | 0.211 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.614926 | 0.211 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.618093 | 0.209 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.621233 | 0.207 |
| R-HSA-418346 | Platelet homeostasis | 0.621233 | 0.207 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.624348 | 0.205 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.624348 | 0.205 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.627438 | 0.202 |
| R-HSA-597592 | Post-translational protein modification | 0.628697 | 0.202 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.630502 | 0.200 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.630502 | 0.200 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.633541 | 0.198 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.633541 | 0.198 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.642511 | 0.192 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.651263 | 0.186 |
| R-HSA-421270 | Cell-cell junction organization | 0.653124 | 0.185 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.659802 | 0.181 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.659802 | 0.181 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.662960 | 0.179 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.665380 | 0.177 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.665380 | 0.177 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.665380 | 0.177 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.673576 | 0.172 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.673576 | 0.172 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.678840 | 0.168 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.681505 | 0.167 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.685659 | 0.164 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.696536 | 0.157 |
| R-HSA-1474165 | Reproduction | 0.699484 | 0.155 |
| R-HSA-9909396 | Circadian clock | 0.704415 | 0.152 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.716395 | 0.145 |
| R-HSA-163685 | Integration of energy metabolism | 0.716395 | 0.145 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.722380 | 0.141 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.733797 | 0.134 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.734568 | 0.134 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.743216 | 0.129 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.745334 | 0.128 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.749518 | 0.125 |
| R-HSA-2142753 | Arachidonate metabolism | 0.753634 | 0.123 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.753634 | 0.123 |
| R-HSA-9609507 | Protein localization | 0.755667 | 0.122 |
| R-HSA-112316 | Neuronal System | 0.767638 | 0.115 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.774185 | 0.111 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.776957 | 0.110 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.789536 | 0.103 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.791274 | 0.102 |
| R-HSA-109582 | Hemostasis | 0.794305 | 0.100 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.794709 | 0.100 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.794709 | 0.100 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.794709 | 0.100 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.798087 | 0.098 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.805526 | 0.094 |
| R-HSA-2559583 | Cellular Senescence | 0.806294 | 0.094 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.815706 | 0.088 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.818741 | 0.087 |
| R-HSA-5617833 | Cilium Assembly | 0.821726 | 0.085 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.823201 | 0.084 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.830394 | 0.081 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.838643 | 0.076 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.839978 | 0.076 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.846343 | 0.072 |
| R-HSA-9679506 | SARS-CoV Infections | 0.854735 | 0.068 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.859659 | 0.066 |
| R-HSA-418990 | Adherens junctions interactions | 0.859914 | 0.066 |
| R-HSA-418594 | G alpha (i) signalling events | 0.868521 | 0.061 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.868937 | 0.061 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.873230 | 0.059 |
| R-HSA-9675108 | Nervous system development | 0.875303 | 0.058 |
| R-HSA-72312 | rRNA processing | 0.875324 | 0.058 |
| R-HSA-1280218 | Adaptive Immune System | 0.876604 | 0.057 |
| R-HSA-8939211 | ESR-mediated signaling | 0.880409 | 0.055 |
| R-HSA-157118 | Signaling by NOTCH | 0.883361 | 0.054 |
| R-HSA-1266738 | Developmental Biology | 0.894890 | 0.048 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.895730 | 0.048 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.904357 | 0.044 |
| R-HSA-416476 | G alpha (q) signalling events | 0.904515 | 0.044 |
| R-HSA-392499 | Metabolism of proteins | 0.910406 | 0.041 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.910582 | 0.041 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.917150 | 0.038 |
| R-HSA-9658195 | Leishmania infection | 0.917150 | 0.038 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.917839 | 0.037 |
| R-HSA-422475 | Axon guidance | 0.948377 | 0.023 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.958658 | 0.018 |
| R-HSA-168256 | Immune System | 0.960599 | 0.017 |
| R-HSA-382551 | Transport of small molecules | 0.967362 | 0.014 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.968142 | 0.014 |
| R-HSA-8978868 | Fatty acid metabolism | 0.971444 | 0.013 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.974834 | 0.011 |
| R-HSA-5668914 | Diseases of metabolism | 0.975873 | 0.011 |
| R-HSA-72766 | Translation | 0.976276 | 0.010 |
| R-HSA-6798695 | Neutrophil degranulation | 0.981270 | 0.008 |
| R-HSA-9824446 | Viral Infection Pathways | 0.986672 | 0.006 |
| R-HSA-388396 | GPCR downstream signalling | 0.990167 | 0.004 |
| R-HSA-1643685 | Disease | 0.991442 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.993888 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 0.994740 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995227 | 0.002 |
| R-HSA-449147 | Signaling by Interleukins | 0.995504 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.996438 | 0.002 |
| R-HSA-5663205 | Infectious disease | 0.998852 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999755 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.851 | 0.748 | 1 | 0.820 |
P38G |
0.849 | 0.821 | 1 | 0.870 |
CDK19 |
0.847 | 0.769 | 1 | 0.830 |
CDK3 |
0.846 | 0.720 | 1 | 0.853 |
CDK18 |
0.846 | 0.775 | 1 | 0.831 |
CDK17 |
0.846 | 0.793 | 1 | 0.857 |
CDK12 |
0.845 | 0.801 | 1 | 0.833 |
CDK13 |
0.844 | 0.796 | 1 | 0.813 |
CDK8 |
0.844 | 0.772 | 1 | 0.797 |
CDK1 |
0.843 | 0.776 | 1 | 0.812 |
CDK5 |
0.843 | 0.769 | 1 | 0.765 |
CDK7 |
0.842 | 0.771 | 1 | 0.794 |
JNK2 |
0.842 | 0.822 | 1 | 0.836 |
KIS |
0.841 | 0.686 | 1 | 0.773 |
CDK9 |
0.838 | 0.786 | 1 | 0.809 |
CDK10 |
0.838 | 0.744 | 1 | 0.805 |
CDK16 |
0.836 | 0.752 | 1 | 0.845 |
ERK1 |
0.836 | 0.774 | 1 | 0.821 |
HIPK1 |
0.834 | 0.697 | 1 | 0.723 |
DYRK2 |
0.834 | 0.713 | 1 | 0.743 |
JNK3 |
0.832 | 0.803 | 1 | 0.812 |
P38D |
0.830 | 0.780 | 1 | 0.872 |
CLK3 |
0.829 | 0.491 | 1 | 0.506 |
DYRK4 |
0.829 | 0.713 | 1 | 0.834 |
CDK14 |
0.829 | 0.753 | 1 | 0.791 |
P38B |
0.828 | 0.768 | 1 | 0.805 |
DYRK1B |
0.827 | 0.705 | 1 | 0.784 |
CDK4 |
0.826 | 0.772 | 1 | 0.837 |
HIPK3 |
0.825 | 0.678 | 1 | 0.699 |
HIPK4 |
0.824 | 0.491 | 1 | 0.530 |
P38A |
0.824 | 0.756 | 1 | 0.738 |
CDK6 |
0.823 | 0.746 | 1 | 0.812 |
ERK2 |
0.823 | 0.766 | 1 | 0.769 |
DYRK1A |
0.821 | 0.606 | 1 | 0.705 |
NLK |
0.821 | 0.707 | 1 | 0.539 |
SRPK1 |
0.819 | 0.372 | -3 | 0.790 |
CDK2 |
0.816 | 0.610 | 1 | 0.694 |
DYRK3 |
0.815 | 0.558 | 1 | 0.689 |
CLK1 |
0.815 | 0.439 | -3 | 0.764 |
CLK2 |
0.811 | 0.428 | -3 | 0.776 |
JNK1 |
0.810 | 0.715 | 1 | 0.832 |
CLK4 |
0.808 | 0.404 | -3 | 0.791 |
SRPK2 |
0.808 | 0.302 | -3 | 0.717 |
MAK |
0.805 | 0.514 | -2 | 0.790 |
ICK |
0.804 | 0.391 | -3 | 0.862 |
ERK5 |
0.802 | 0.366 | 1 | 0.454 |
CDKL5 |
0.801 | 0.207 | -3 | 0.829 |
MOK |
0.800 | 0.501 | 1 | 0.609 |
MTOR |
0.799 | 0.217 | 1 | 0.338 |
SRPK3 |
0.796 | 0.278 | -3 | 0.761 |
PRP4 |
0.793 | 0.465 | -3 | 0.834 |
CDKL1 |
0.793 | 0.170 | -3 | 0.833 |
MST4 |
0.790 | 0.075 | 2 | 0.747 |
NDR2 |
0.789 | 0.054 | -3 | 0.858 |
COT |
0.788 | -0.081 | 2 | 0.664 |
PIM3 |
0.787 | 0.016 | -3 | 0.859 |
CDC7 |
0.786 | -0.040 | 1 | 0.178 |
ERK7 |
0.785 | 0.260 | 2 | 0.467 |
NDR1 |
0.785 | 0.031 | -3 | 0.850 |
NUAK2 |
0.785 | 0.066 | -3 | 0.847 |
WNK1 |
0.784 | 0.001 | -2 | 0.916 |
PKCD |
0.783 | 0.032 | 2 | 0.625 |
RSK2 |
0.783 | 0.060 | -3 | 0.800 |
PKN3 |
0.783 | 0.000 | -3 | 0.851 |
PRPK |
0.783 | -0.053 | -1 | 0.839 |
RSK3 |
0.782 | 0.051 | -3 | 0.803 |
PRKD1 |
0.782 | 0.044 | -3 | 0.858 |
CAMK1B |
0.782 | 0.020 | -3 | 0.870 |
MOS |
0.782 | -0.010 | 1 | 0.215 |
NEK6 |
0.781 | -0.014 | -2 | 0.864 |
AURC |
0.781 | 0.088 | -2 | 0.742 |
PRKD2 |
0.781 | 0.059 | -3 | 0.793 |
P90RSK |
0.781 | 0.050 | -3 | 0.812 |
GCN2 |
0.780 | -0.156 | 2 | 0.662 |
ULK2 |
0.780 | -0.141 | 2 | 0.650 |
PKN2 |
0.780 | -0.009 | -3 | 0.847 |
TBK1 |
0.779 | -0.146 | 1 | 0.135 |
TGFBR2 |
0.779 | -0.029 | -2 | 0.815 |
P70S6KB |
0.777 | 0.054 | -3 | 0.817 |
PIM1 |
0.777 | 0.058 | -3 | 0.802 |
NIK |
0.777 | 0.011 | -3 | 0.883 |
TSSK1 |
0.777 | 0.034 | -3 | 0.880 |
PKACG |
0.777 | 0.036 | -2 | 0.814 |
ATR |
0.776 | -0.040 | 1 | 0.203 |
AMPKA1 |
0.776 | -0.015 | -3 | 0.864 |
CAMLCK |
0.776 | 0.043 | -2 | 0.891 |
PHKG1 |
0.776 | -0.008 | -3 | 0.838 |
MNK2 |
0.775 | 0.030 | -2 | 0.860 |
IRE1 |
0.775 | -0.037 | 1 | 0.146 |
PRKD3 |
0.775 | 0.056 | -3 | 0.773 |
PKCA |
0.774 | 0.022 | 2 | 0.596 |
PKCB |
0.774 | 0.010 | 2 | 0.594 |
BMPR2 |
0.774 | -0.129 | -2 | 0.889 |
NEK7 |
0.773 | -0.113 | -3 | 0.838 |
CHAK2 |
0.773 | -0.043 | -1 | 0.810 |
PDHK4 |
0.773 | -0.131 | 1 | 0.222 |
PKCG |
0.773 | 0.001 | 2 | 0.592 |
AMPKA2 |
0.773 | -0.000 | -3 | 0.833 |
MAPKAPK3 |
0.773 | -0.012 | -3 | 0.807 |
RAF1 |
0.772 | -0.174 | 1 | 0.158 |
PDHK1 |
0.772 | -0.084 | 1 | 0.203 |
AKT2 |
0.772 | 0.093 | -3 | 0.718 |
DAPK2 |
0.771 | 0.006 | -3 | 0.880 |
NUAK1 |
0.771 | 0.013 | -3 | 0.804 |
IKKE |
0.771 | -0.178 | 1 | 0.134 |
SKMLCK |
0.771 | -0.033 | -2 | 0.915 |
LATS2 |
0.771 | -0.011 | -5 | 0.745 |
MNK1 |
0.770 | 0.029 | -2 | 0.865 |
MAPKAPK2 |
0.770 | 0.014 | -3 | 0.762 |
WNK3 |
0.770 | -0.134 | 1 | 0.156 |
AURB |
0.770 | 0.057 | -2 | 0.738 |
DSTYK |
0.770 | -0.147 | 2 | 0.677 |
SGK3 |
0.770 | 0.050 | -3 | 0.796 |
ULK1 |
0.770 | -0.149 | -3 | 0.818 |
PAK3 |
0.770 | -0.017 | -2 | 0.841 |
IRE2 |
0.769 | -0.043 | 2 | 0.604 |
RSK4 |
0.769 | 0.053 | -3 | 0.769 |
PKG2 |
0.769 | 0.051 | -2 | 0.760 |
TSSK2 |
0.769 | -0.040 | -5 | 0.835 |
PKCH |
0.768 | -0.014 | 2 | 0.592 |
MARK4 |
0.768 | -0.065 | 4 | 0.784 |
MLK1 |
0.768 | -0.134 | 2 | 0.671 |
PKCZ |
0.768 | -0.004 | 2 | 0.645 |
PAK1 |
0.768 | -0.004 | -2 | 0.850 |
MELK |
0.768 | -0.021 | -3 | 0.822 |
PKACB |
0.767 | 0.068 | -2 | 0.764 |
IKKB |
0.767 | -0.174 | -2 | 0.725 |
RIPK3 |
0.767 | -0.142 | 3 | 0.783 |
NIM1 |
0.766 | -0.067 | 3 | 0.815 |
PIM2 |
0.766 | 0.076 | -3 | 0.774 |
HUNK |
0.765 | -0.147 | 2 | 0.654 |
MLK2 |
0.765 | -0.092 | 2 | 0.676 |
MLK3 |
0.765 | -0.055 | 2 | 0.601 |
CAMK2D |
0.765 | -0.066 | -3 | 0.855 |
PAK6 |
0.764 | 0.018 | -2 | 0.750 |
NEK9 |
0.764 | -0.132 | 2 | 0.706 |
CAMK4 |
0.764 | -0.069 | -3 | 0.823 |
PKCT |
0.764 | 0.005 | 2 | 0.598 |
CAMK2G |
0.764 | -0.137 | 2 | 0.595 |
AKT1 |
0.762 | 0.070 | -3 | 0.734 |
MSK2 |
0.762 | -0.007 | -3 | 0.783 |
PKR |
0.762 | -0.005 | 1 | 0.169 |
BMPR1B |
0.761 | -0.026 | 1 | 0.153 |
QSK |
0.761 | -0.022 | 4 | 0.770 |
VRK2 |
0.761 | 0.105 | 1 | 0.265 |
RIPK1 |
0.761 | -0.158 | 1 | 0.145 |
NEK2 |
0.760 | -0.084 | 2 | 0.695 |
BCKDK |
0.760 | -0.134 | -1 | 0.731 |
SIK |
0.760 | -0.018 | -3 | 0.784 |
CHAK1 |
0.760 | -0.102 | 2 | 0.676 |
DCAMKL1 |
0.760 | 0.006 | -3 | 0.805 |
PAK2 |
0.760 | -0.026 | -2 | 0.830 |
MASTL |
0.759 | -0.174 | -2 | 0.819 |
GRK5 |
0.759 | -0.159 | -3 | 0.857 |
PINK1 |
0.759 | 0.155 | 1 | 0.349 |
PHKG2 |
0.759 | -0.031 | -3 | 0.799 |
QIK |
0.759 | -0.078 | -3 | 0.843 |
TTBK2 |
0.759 | -0.179 | 2 | 0.585 |
BRSK2 |
0.759 | -0.062 | -3 | 0.829 |
AURA |
0.758 | 0.028 | -2 | 0.707 |
WNK4 |
0.758 | -0.027 | -2 | 0.899 |
ALK4 |
0.758 | -0.047 | -2 | 0.848 |
PKCI |
0.758 | 0.025 | 2 | 0.631 |
DLK |
0.758 | -0.187 | 1 | 0.177 |
ANKRD3 |
0.758 | -0.163 | 1 | 0.174 |
PRKX |
0.758 | 0.068 | -3 | 0.703 |
P70S6K |
0.758 | 0.043 | -3 | 0.742 |
MSK1 |
0.758 | 0.013 | -3 | 0.788 |
AKT3 |
0.757 | 0.093 | -3 | 0.666 |
PLK4 |
0.757 | -0.106 | 2 | 0.529 |
PKCE |
0.757 | 0.043 | 2 | 0.590 |
LATS1 |
0.756 | -0.017 | -3 | 0.873 |
MLK4 |
0.756 | -0.098 | 2 | 0.589 |
MYLK4 |
0.756 | -0.002 | -2 | 0.834 |
MPSK1 |
0.756 | 0.058 | 1 | 0.207 |
TGFBR1 |
0.756 | -0.048 | -2 | 0.823 |
MST3 |
0.755 | -0.001 | 2 | 0.707 |
DNAPK |
0.755 | -0.055 | 1 | 0.184 |
GSK3A |
0.755 | 0.165 | 4 | 0.362 |
IKKA |
0.754 | -0.112 | -2 | 0.711 |
GRK7 |
0.754 | -0.021 | 1 | 0.186 |
TLK2 |
0.754 | -0.059 | 1 | 0.140 |
BRSK1 |
0.754 | -0.055 | -3 | 0.816 |
CAMK1G |
0.754 | -0.024 | -3 | 0.776 |
PKN1 |
0.753 | 0.015 | -3 | 0.751 |
YSK4 |
0.753 | -0.146 | 1 | 0.141 |
PKACA |
0.753 | 0.052 | -2 | 0.715 |
CAMK2A |
0.753 | -0.039 | 2 | 0.572 |
IRAK4 |
0.753 | -0.093 | 1 | 0.138 |
SNRK |
0.752 | -0.125 | 2 | 0.581 |
DCAMKL2 |
0.752 | -0.033 | -3 | 0.817 |
SSTK |
0.752 | -0.026 | 4 | 0.761 |
ATM |
0.752 | -0.104 | 1 | 0.173 |
MEK1 |
0.751 | -0.129 | 2 | 0.687 |
GRK1 |
0.751 | -0.089 | -2 | 0.771 |
CAMK2B |
0.751 | -0.076 | 2 | 0.551 |
PERK |
0.751 | -0.090 | -2 | 0.823 |
SMG1 |
0.750 | -0.076 | 1 | 0.184 |
MAPKAPK5 |
0.750 | -0.055 | -3 | 0.761 |
CHK1 |
0.750 | -0.040 | -3 | 0.841 |
ACVR2A |
0.750 | -0.075 | -2 | 0.799 |
MARK3 |
0.750 | -0.057 | 4 | 0.720 |
HRI |
0.749 | -0.117 | -2 | 0.856 |
PAK5 |
0.749 | 0.003 | -2 | 0.702 |
PLK1 |
0.749 | -0.161 | -2 | 0.815 |
GRK6 |
0.749 | -0.176 | 1 | 0.162 |
ZAK |
0.749 | -0.130 | 1 | 0.162 |
SGK1 |
0.748 | 0.086 | -3 | 0.651 |
MEK5 |
0.748 | -0.113 | 2 | 0.686 |
DRAK1 |
0.748 | -0.138 | 1 | 0.123 |
GRK4 |
0.748 | -0.185 | -2 | 0.825 |
ACVR2B |
0.747 | -0.088 | -2 | 0.808 |
SMMLCK |
0.747 | 0.001 | -3 | 0.832 |
MARK2 |
0.746 | -0.071 | 4 | 0.691 |
BUB1 |
0.746 | 0.056 | -5 | 0.846 |
TAO3 |
0.746 | -0.028 | 1 | 0.184 |
MEKK2 |
0.746 | -0.097 | 2 | 0.665 |
PAK4 |
0.745 | 0.003 | -2 | 0.711 |
MRCKB |
0.745 | 0.064 | -3 | 0.760 |
NEK5 |
0.745 | -0.114 | 1 | 0.150 |
BMPR1A |
0.745 | -0.036 | 1 | 0.149 |
ALK2 |
0.744 | -0.073 | -2 | 0.817 |
TLK1 |
0.743 | -0.121 | -2 | 0.842 |
MEKK6 |
0.743 | -0.041 | 1 | 0.170 |
MEKK1 |
0.743 | -0.143 | 1 | 0.171 |
SBK |
0.743 | 0.141 | -3 | 0.603 |
CAMK1D |
0.742 | -0.002 | -3 | 0.712 |
FAM20C |
0.742 | -0.087 | 2 | 0.385 |
MRCKA |
0.741 | 0.048 | -3 | 0.774 |
CHK2 |
0.741 | 0.024 | -3 | 0.665 |
GSK3B |
0.741 | 0.026 | 4 | 0.356 |
TAO2 |
0.740 | -0.039 | 2 | 0.677 |
MEKK3 |
0.740 | -0.182 | 1 | 0.163 |
EEF2K |
0.740 | -0.017 | 3 | 0.930 |
MARK1 |
0.740 | -0.096 | 4 | 0.737 |
HGK |
0.739 | -0.015 | 3 | 0.943 |
MAP3K15 |
0.739 | -0.069 | 1 | 0.172 |
PDK1 |
0.739 | -0.045 | 1 | 0.197 |
CAMK1A |
0.739 | 0.021 | -3 | 0.682 |
LKB1 |
0.738 | -0.012 | -3 | 0.847 |
ROCK2 |
0.738 | 0.046 | -3 | 0.811 |
TNIK |
0.738 | 0.004 | 3 | 0.936 |
NEK8 |
0.737 | -0.132 | 2 | 0.680 |
GAK |
0.737 | -0.022 | 1 | 0.203 |
PKG1 |
0.737 | 0.029 | -2 | 0.691 |
LOK |
0.737 | -0.019 | -2 | 0.784 |
BRAF |
0.737 | -0.147 | -4 | 0.828 |
PLK3 |
0.737 | -0.162 | 2 | 0.573 |
GRK2 |
0.737 | -0.109 | -2 | 0.713 |
PASK |
0.737 | -0.054 | -3 | 0.866 |
HASPIN |
0.736 | 0.027 | -1 | 0.674 |
CRIK |
0.736 | 0.095 | -3 | 0.736 |
DAPK3 |
0.735 | -0.008 | -3 | 0.815 |
PBK |
0.735 | 0.001 | 1 | 0.184 |
NEK11 |
0.735 | -0.141 | 1 | 0.175 |
YSK1 |
0.734 | -0.036 | 2 | 0.698 |
TTBK1 |
0.734 | -0.172 | 2 | 0.513 |
KHS1 |
0.734 | -0.007 | 1 | 0.151 |
KHS2 |
0.734 | 0.020 | 1 | 0.157 |
NEK4 |
0.734 | -0.119 | 1 | 0.134 |
MINK |
0.734 | -0.066 | 1 | 0.137 |
GCK |
0.733 | -0.062 | 1 | 0.154 |
HPK1 |
0.733 | -0.041 | 1 | 0.152 |
LRRK2 |
0.733 | -0.002 | 2 | 0.702 |
DMPK1 |
0.733 | 0.076 | -3 | 0.767 |
CK1E |
0.731 | -0.060 | -3 | 0.513 |
NEK3 |
0.731 | -0.028 | 1 | 0.173 |
CK1G1 |
0.730 | -0.076 | -3 | 0.517 |
NEK1 |
0.729 | -0.106 | 1 | 0.135 |
STK33 |
0.729 | -0.110 | 2 | 0.509 |
DAPK1 |
0.729 | -0.015 | -3 | 0.799 |
ROCK1 |
0.727 | 0.034 | -3 | 0.775 |
MST2 |
0.726 | -0.138 | 1 | 0.150 |
VRK1 |
0.726 | -0.151 | 2 | 0.666 |
IRAK1 |
0.726 | -0.219 | -1 | 0.720 |
CAMKK2 |
0.725 | -0.119 | -2 | 0.713 |
SLK |
0.724 | -0.064 | -2 | 0.724 |
CAMKK1 |
0.723 | -0.196 | -2 | 0.710 |
CK1D |
0.723 | -0.037 | -3 | 0.460 |
OSR1 |
0.723 | -0.025 | 2 | 0.695 |
BIKE |
0.723 | -0.010 | 1 | 0.189 |
TAK1 |
0.722 | -0.166 | 1 | 0.146 |
MST1 |
0.722 | -0.132 | 1 | 0.136 |
GRK3 |
0.722 | -0.107 | -2 | 0.671 |
AAK1 |
0.721 | 0.027 | 1 | 0.191 |
RIPK2 |
0.720 | -0.200 | 1 | 0.141 |
MEK2 |
0.720 | -0.157 | 2 | 0.686 |
MYO3B |
0.720 | -0.018 | 2 | 0.695 |
CK1A2 |
0.720 | -0.058 | -3 | 0.459 |
LIMK2_TYR |
0.719 | 0.187 | -3 | 0.894 |
CK2A2 |
0.716 | -0.099 | 1 | 0.120 |
TAO1 |
0.716 | -0.061 | 1 | 0.156 |
PDHK3_TYR |
0.714 | 0.092 | 4 | 0.829 |
MYO3A |
0.714 | -0.053 | 1 | 0.147 |
PKMYT1_TYR |
0.713 | 0.145 | 3 | 0.885 |
ASK1 |
0.712 | -0.120 | 1 | 0.173 |
TTK |
0.711 | -0.095 | -2 | 0.842 |
TESK1_TYR |
0.711 | 0.055 | 3 | 0.918 |
CK2A1 |
0.707 | -0.109 | 1 | 0.110 |
MAP2K4_TYR |
0.706 | 0.026 | -1 | 0.839 |
TNNI3K_TYR |
0.705 | 0.040 | 1 | 0.215 |
MAP2K7_TYR |
0.705 | -0.074 | 2 | 0.685 |
PLK2 |
0.705 | -0.125 | -3 | 0.778 |
LIMK1_TYR |
0.703 | 0.018 | 2 | 0.690 |
PINK1_TYR |
0.703 | -0.098 | 1 | 0.213 |
PDHK4_TYR |
0.702 | -0.009 | 2 | 0.687 |
MAP2K6_TYR |
0.701 | -0.025 | -1 | 0.835 |
YANK3 |
0.700 | -0.078 | 2 | 0.301 |
ALPHAK3 |
0.700 | -0.101 | -1 | 0.752 |
RET |
0.699 | -0.131 | 1 | 0.188 |
BMPR2_TYR |
0.699 | -0.032 | -1 | 0.813 |
PDHK1_TYR |
0.699 | -0.084 | -1 | 0.836 |
NEK10_TYR |
0.698 | -0.046 | 1 | 0.152 |
STLK3 |
0.698 | -0.146 | 1 | 0.141 |
ROS1 |
0.697 | -0.121 | 3 | 0.835 |
MST1R |
0.696 | -0.106 | 3 | 0.835 |
TYK2 |
0.695 | -0.174 | 1 | 0.178 |
JAK2 |
0.695 | -0.123 | 1 | 0.206 |
TYRO3 |
0.695 | -0.147 | 3 | 0.856 |
TNK1 |
0.693 | -0.052 | 3 | 0.828 |
JAK1 |
0.693 | -0.079 | 1 | 0.173 |
CSF1R |
0.691 | -0.130 | 3 | 0.820 |
TXK |
0.691 | -0.087 | 1 | 0.156 |
JAK3 |
0.691 | -0.136 | 1 | 0.186 |
DDR1 |
0.690 | -0.132 | 4 | 0.745 |
EPHA6 |
0.689 | -0.139 | -1 | 0.792 |
FGFR1 |
0.689 | -0.059 | 3 | 0.790 |
YES1 |
0.688 | -0.112 | -1 | 0.797 |
FGFR2 |
0.688 | -0.082 | 3 | 0.815 |
TEK |
0.687 | -0.039 | 3 | 0.788 |
EPHB4 |
0.687 | -0.169 | -1 | 0.774 |
FGR |
0.686 | -0.157 | 1 | 0.150 |
LCK |
0.686 | -0.094 | -1 | 0.777 |
ITK |
0.685 | -0.139 | -1 | 0.753 |
TNK2 |
0.685 | -0.124 | 3 | 0.770 |
WEE1_TYR |
0.684 | -0.056 | -1 | 0.728 |
ABL2 |
0.684 | -0.147 | -1 | 0.768 |
PDGFRB |
0.683 | -0.196 | 3 | 0.844 |
KDR |
0.683 | -0.110 | 3 | 0.774 |
CK1A |
0.683 | -0.080 | -3 | 0.369 |
BLK |
0.682 | -0.103 | -1 | 0.777 |
ABL1 |
0.681 | -0.151 | -1 | 0.765 |
HCK |
0.681 | -0.160 | -1 | 0.775 |
INSRR |
0.681 | -0.174 | 3 | 0.798 |
FLT3 |
0.680 | -0.196 | 3 | 0.843 |
FER |
0.680 | -0.212 | 1 | 0.173 |
DDR2 |
0.679 | -0.048 | 3 | 0.778 |
KIT |
0.679 | -0.163 | 3 | 0.819 |
PDGFRA |
0.678 | -0.205 | 3 | 0.849 |
AXL |
0.678 | -0.183 | 3 | 0.789 |
BMX |
0.678 | -0.119 | -1 | 0.696 |
TEC |
0.676 | -0.150 | -1 | 0.711 |
EPHB1 |
0.676 | -0.214 | 1 | 0.160 |
MET |
0.675 | -0.143 | 3 | 0.801 |
MERTK |
0.675 | -0.181 | 3 | 0.782 |
ALK |
0.675 | -0.166 | 3 | 0.774 |
EPHA4 |
0.675 | -0.150 | 2 | 0.566 |
EPHB3 |
0.674 | -0.202 | -1 | 0.754 |
SRMS |
0.674 | -0.217 | 1 | 0.151 |
FGFR3 |
0.673 | -0.112 | 3 | 0.784 |
EPHB2 |
0.672 | -0.200 | -1 | 0.752 |
BTK |
0.672 | -0.219 | -1 | 0.719 |
PTK6 |
0.671 | -0.190 | -1 | 0.706 |
FRK |
0.671 | -0.167 | -1 | 0.782 |
FYN |
0.670 | -0.120 | -1 | 0.757 |
LTK |
0.670 | -0.178 | 3 | 0.777 |
FLT1 |
0.669 | -0.167 | -1 | 0.753 |
ERBB2 |
0.669 | -0.184 | 1 | 0.163 |
FLT4 |
0.669 | -0.174 | 3 | 0.775 |
EPHA1 |
0.669 | -0.182 | 3 | 0.776 |
EPHA7 |
0.666 | -0.175 | 2 | 0.576 |
INSR |
0.666 | -0.187 | 3 | 0.780 |
MUSK |
0.666 | -0.135 | 1 | 0.117 |
PTK2B |
0.666 | -0.143 | -1 | 0.754 |
MATK |
0.665 | -0.116 | -1 | 0.703 |
NTRK2 |
0.665 | -0.230 | 3 | 0.773 |
EGFR |
0.664 | -0.136 | 1 | 0.148 |
YANK2 |
0.663 | -0.102 | 2 | 0.305 |
LYN |
0.663 | -0.167 | 3 | 0.760 |
NTRK1 |
0.663 | -0.252 | -1 | 0.755 |
SRC |
0.663 | -0.143 | -1 | 0.759 |
NTRK3 |
0.663 | -0.176 | -1 | 0.717 |
EPHA3 |
0.660 | -0.201 | 2 | 0.550 |
CSK |
0.658 | -0.176 | 2 | 0.585 |
EPHA8 |
0.657 | -0.167 | -1 | 0.731 |
FGFR4 |
0.657 | -0.140 | -1 | 0.724 |
CK1G3 |
0.655 | -0.095 | -3 | 0.322 |
EPHA5 |
0.652 | -0.210 | 2 | 0.542 |
IGF1R |
0.651 | -0.171 | 3 | 0.719 |
PTK2 |
0.651 | -0.118 | -1 | 0.701 |
SYK |
0.649 | -0.133 | -1 | 0.702 |
ERBB4 |
0.648 | -0.133 | 1 | 0.145 |
EPHA2 |
0.647 | -0.178 | -1 | 0.693 |
ZAP70 |
0.640 | -0.091 | -1 | 0.655 |
FES |
0.638 | -0.169 | -1 | 0.680 |
CK1G2 |
0.636 | -0.098 | -3 | 0.423 |