Motif 499 (n=100)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O14867 | BACH1 | S380 | ochoa | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}. |
| O15504 | NUP42 | S85 | ochoa | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}. |
| O43194 | GPR39 | S256 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O43293 | DAPK3 | S309 | ochoa | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
| O43586 | PSTPIP1 | S327 | ochoa | Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) | Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. {ECO:0000250, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}. |
| O60343 | TBC1D4 | S566 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O75069 | TMCC2 | S75 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75665 | OFD1 | S720 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O94804 | STK10 | S417 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| P05186 | ALPL | S110 | ochoa | Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1) | Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:12162492, PubMed:23688511, PubMed:25982064). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (PubMed:12162492, PubMed:2220817). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:23688511, PubMed:25982064). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (PubMed:20049532, PubMed:2220817). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (PubMed:28448526). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:P09242, ECO:0000269|PubMed:12162492, ECO:0000269|PubMed:20049532, ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064, ECO:0000269|PubMed:28448526}. |
| P05187 | ALPP | S114 | ochoa | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P06733 | ENO1 | S37 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07900 | HSP90AA1 | S50 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S45 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09104 | ENO2 | S37 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
| P09923 | ALPI | S111 | ochoa | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P10696 | ALPG | S111 | ochoa | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| P13929 | ENO3 | S37 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P14625 | HSP90B1 | S106 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P17066 | HSPA6 | S59 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P23193 | TCEA1 | S128 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P30084 | ECHS1 | S186 | ochoa | Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH) | Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity). {ECO:0000250|UniProtKB:P14604, ECO:0000269|PubMed:25125611, ECO:0000269|PubMed:26251176}. |
| P32322 | PYCR1 | S294 | ochoa | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921). {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921, ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:28258219}. |
| P48741 | HSPA7 | S59 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P49748 | ACADVL | S57 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P51955 | NEK2 | S365 | ochoa|psp | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P54132 | BLM | S499 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55265 | ADAR | S481 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P82094 | TMF1 | S320 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01970 | PLCB3 | S926 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q03164 | KMT2A | S996 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q04656 | ATP7A | S1460 | psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q04724 | TLE1 | S286 | ochoa|psp | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000250|UniProtKB:Q62440, ECO:0000269|PubMed:10660609}. |
| Q04726 | TLE3 | S286 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q04727 | TLE4 | S292 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
| Q04759 | PRKCQ | S676 | ochoa|psp | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| Q05655 | PRKCD | S503 | ochoa|psp | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q09666 | AHNAK | S1023 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13422 | IKZF1 | S361 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13492 | PICALM | S308 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q14258 | TRIM25 | S187 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14568 | HSP90AA2P | S50 | ochoa | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q2NKX8 | ERCC6L | S988 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q4KWH8 | PLCH1 | S1247 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q5SRE5 | NUP188 | S1523 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5SSJ5 | HP1BP3 | S176 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5SW79 | CEP170 | S1270 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5VV42 | CDKAL1 | S527 | ochoa | Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) | Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}. |
| Q5VWN6 | TASOR2 | S1530 | ochoa | Protein TASOR 2 | None |
| Q5VZ89 | DENND4C | S1064 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6DN90 | IQSEC1 | S230 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6KC79 | NIPBL | S228 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P2E9 | EDC4 | S771 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P6C2 | ALKBH5 | S305 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6ZSZ6 | TSHZ1 | S827 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q7LBC6 | KDM3B | S455 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z6J0 | SH3RF1 | S315 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q7Z7G8 | VPS13B | S1812 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86SJ2 | AMIGO2 | S438 | ochoa | Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA) | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. |
| Q86SQ0 | PHLDB2 | S309 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86VZ1 | P2RY8 | S332 | ochoa | S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8) | G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed:25274307, PubMed:30842656, PubMed:34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed:25274307, PubMed:30842656, PubMed:34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed:30842656, PubMed:34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed:25274307). {ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:30842656, ECO:0000269|PubMed:34088745}. |
| Q86X29 | LSR | S382 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86YP4 | GATAD2A | S340 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8ND25 | ZNRF1 | S123 | ochoa | E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) | E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:28593998, ECO:0000269|PubMed:29626159, ECO:0000269|PubMed:33996800, ECO:0000269|PubMed:37158982, ECO:0000305|PubMed:14561866}. |
| Q8WUM0 | NUP133 | S489 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q96HC4 | PDLIM5 | S257 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96L73 | NSD1 | S483 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96MF7 | NSMCE2 | S116 | ochoa | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316). Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316). The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850). Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526). SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526). Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785). {ECO:0000269|PubMed:16055714, ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:31400850}. |
| Q96N64 | PWWP2A | S578 | ochoa | PWWP domain-containing protein 2A | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}. |
| Q96TC7 | RMDN3 | S221 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99466 | NOTCH4 | S125 | ochoa | Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain] | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). {ECO:0000250}. |
| Q99590 | SCAF11 | S393 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BWF3 | RBM4 | S334 | ochoa | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9BZ29 | DOCK9 | S1283 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9HCK8 | CHD8 | S296 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NQW6 | ANLN | S45 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR45 | NANS | S248 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
| Q9NUY8 | TBC1D23 | S466 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
| Q9NYB0 | TERF2IP | S27 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NZ72 | STMN3 | S65 | ochoa | Stathmin-3 (SCG10-like protein) | Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}. |
| Q9P265 | DIP2B | S255 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UBY0 | SLC9A2 | S687 | ochoa | Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). {ECO:0000250|UniProtKB:Q3ZAS0, ECO:0000269|PubMed:10444453}. |
| Q9UHV7 | MED13 | S826 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9UI33 | SCN11A | S524 | ochoa | Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN) | Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:10580103, PubMed:12384689, PubMed:24036948, PubMed:24776970, PubMed:25791876, PubMed:26645915). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948, PubMed:24776970, PubMed:25791876, PubMed:26645915). Also involved in rapid BDNF-evoked neuronal depolarization (PubMed:12384689). {ECO:0000269|PubMed:10580103, ECO:0000269|PubMed:12384689, ECO:0000269|PubMed:24036948, ECO:0000269|PubMed:24776970, ECO:0000269|PubMed:25791876, ECO:0000269|PubMed:26645915}. |
| Q9UJD0 | RIMS3 | S104 | ochoa | Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) | Regulates synaptic membrane exocytosis. {ECO:0000250}. |
| Q9ULD6 | INTU | S450 | ochoa | Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) | Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Required for recruitment of CPLANE2 to the mother centriole (By similarity). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity). {ECO:0000250|UniProtKB:Q059U7, ECO:0000250|UniProtKB:Q2I0E5, ECO:0000305|PubMed:27158779}. |
| Q9UMZ2 | SYNRG | S1006 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UQ26 | RIMS2 | S1205 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9UQ35 | SRRM2 | S142 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y5S2 | CDC42BPB | S1527 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| P17174 | GOT1 | S82 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| Q9NYU2 | UGGT1 | S445 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| P24752 | ACAT1 | S69 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| P43403 | ZAP70 | S260 | Sugiyama | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| O60563 | CCNT1 | S369 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| P34896 | SHMT1 | S381 | Sugiyama | Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Interconversion of serine and glycine (PubMed:24698160, PubMed:8505317). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}. |
| Q14164 | IKBKE | S479 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| O15355 | PPM1G | S354 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| Q5SW79 | CEP170 | S551 | Sugiyama | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q9P227 | ARHGAP23 | S127 | EPSD|PSP | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371556 | Cellular response to heat stress | 0.000007 | 5.159 |
| R-HSA-4641265 | Repression of WNT target genes | 0.000229 | 3.641 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.000183 | 3.737 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.000173 | 3.761 |
| R-HSA-70171 | Glycolysis | 0.000167 | 3.778 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000313 | 3.505 |
| R-HSA-70326 | Glucose metabolism | 0.000401 | 3.397 |
| R-HSA-2262752 | Cellular responses to stress | 0.001275 | 2.895 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.002346 | 2.630 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.002533 | 2.596 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.002533 | 2.596 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.002936 | 2.532 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.002936 | 2.532 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.003151 | 2.501 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.003196 | 2.495 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.003151 | 2.501 |
| R-HSA-157118 | Signaling by NOTCH | 0.002888 | 2.539 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.002454 | 2.610 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.002142 | 2.669 |
| R-HSA-1640170 | Cell Cycle | 0.002356 | 2.628 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.002226 | 2.653 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.001741 | 2.759 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.003610 | 2.442 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.004646 | 2.333 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.004930 | 2.307 |
| R-HSA-3371568 | Attenuation phase | 0.004930 | 2.307 |
| R-HSA-3371511 | HSF1 activation | 0.003854 | 2.414 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.004108 | 2.386 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.003376 | 2.472 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.004089 | 2.388 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.004930 | 2.307 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.004930 | 2.307 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.003501 | 2.456 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.004372 | 2.359 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.004646 | 2.333 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.005224 | 2.282 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.005394 | 2.268 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.006252 | 2.204 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.006853 | 2.164 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.006863 | 2.163 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.007211 | 2.142 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.007259 | 2.139 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.008493 | 2.071 |
| R-HSA-68886 | M Phase | 0.008985 | 2.046 |
| R-HSA-162587 | HIV Life Cycle | 0.008996 | 2.046 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.008391 | 2.076 |
| R-HSA-913531 | Interferon Signaling | 0.009111 | 2.040 |
| R-HSA-70263 | Gluconeogenesis | 0.007959 | 2.099 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.008350 | 2.078 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.009165 | 2.038 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.009367 | 2.028 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.010279 | 1.988 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.012216 | 1.913 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.011881 | 1.925 |
| R-HSA-211000 | Gene Silencing by RNA | 0.011098 | 1.955 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.012374 | 1.907 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.013239 | 1.878 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.014299 | 1.845 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.014299 | 1.845 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.014299 | 1.845 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.014299 | 1.845 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.012879 | 1.890 |
| R-HSA-191859 | snRNP Assembly | 0.012879 | 1.890 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.013923 | 1.856 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.013239 | 1.878 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.014305 | 1.845 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.014462 | 1.840 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.015014 | 1.824 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.015014 | 1.824 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.016738 | 1.776 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.017947 | 1.746 |
| R-HSA-8964038 | LDL clearance | 0.017688 | 1.752 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.017782 | 1.750 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.018107 | 1.742 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.021381 | 1.670 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 0.021381 | 1.670 |
| R-HSA-9916720 | Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 | 0.021381 | 1.670 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.021381 | 1.670 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.021177 | 1.674 |
| R-HSA-380287 | Centrosome maturation | 0.022552 | 1.647 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.022678 | 1.644 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.021177 | 1.674 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.022678 | 1.644 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.021381 | 1.670 |
| R-HSA-68877 | Mitotic Prometaphase | 0.019082 | 1.719 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.019203 | 1.717 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.020507 | 1.688 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.022678 | 1.644 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.028407 | 1.547 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.028407 | 1.547 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.028407 | 1.547 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.028407 | 1.547 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.028407 | 1.547 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.028407 | 1.547 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.028407 | 1.547 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.028407 | 1.547 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.028407 | 1.547 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.028407 | 1.547 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.028407 | 1.547 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.024006 | 1.620 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.024006 | 1.620 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.024006 | 1.620 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.025365 | 1.596 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.025365 | 1.596 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.026755 | 1.573 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.027742 | 1.557 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.028407 | 1.547 |
| R-HSA-75102 | C6 deamination of adenosine | 0.028407 | 1.547 |
| R-HSA-622312 | Inflammasomes | 0.025365 | 1.596 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.026428 | 1.578 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.025231 | 1.598 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.025758 | 1.589 |
| R-HSA-162582 | Signal Transduction | 0.024991 | 1.602 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.023258 | 1.633 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.026832 | 1.571 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.029331 | 1.533 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.029624 | 1.528 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.031103 | 1.507 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.042309 | 1.374 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.033512 | 1.475 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.035267 | 1.453 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.034147 | 1.467 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.032611 | 1.487 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.032611 | 1.487 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.035710 | 1.447 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.040563 | 1.392 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.035710 | 1.447 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.042233 | 1.374 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.037301 | 1.428 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.042309 | 1.374 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.036162 | 1.442 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.037040 | 1.431 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.032611 | 1.487 |
| R-HSA-162906 | HIV Infection | 0.033722 | 1.472 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.034147 | 1.467 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.043928 | 1.357 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.043928 | 1.357 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.043928 | 1.357 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.045648 | 1.341 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.045648 | 1.341 |
| R-HSA-167169 | HIV Transcription Elongation | 0.045648 | 1.341 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.047393 | 1.324 |
| R-HSA-72306 | tRNA processing | 0.048434 | 1.315 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.049162 | 1.308 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.051315 | 1.290 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.052042 | 1.284 |
| R-HSA-168255 | Influenza Infection | 0.055605 | 1.255 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.056013 | 1.252 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.056471 | 1.248 |
| R-HSA-9679506 | SARS-CoV Infections | 0.057094 | 1.243 |
| R-HSA-73894 | DNA Repair | 0.057544 | 1.240 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.058355 | 1.234 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.058355 | 1.234 |
| R-HSA-9675135 | Diseases of DNA repair | 0.058355 | 1.234 |
| R-HSA-75153 | Apoptotic execution phase | 0.058355 | 1.234 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.058967 | 1.229 |
| R-HSA-69275 | G2/M Transition | 0.061559 | 1.211 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.062186 | 1.206 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.062224 | 1.206 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.069524 | 1.158 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.082842 | 1.082 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.070095 | 1.154 |
| R-HSA-180786 | Extension of Telomeres | 0.084664 | 1.072 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.072121 | 1.142 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.069524 | 1.158 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 0.089430 | 1.049 |
| R-HSA-8964046 | VLDL clearance | 0.069524 | 1.158 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.076207 | 1.118 |
| R-HSA-75072 | mRNA Editing | 0.082842 | 1.082 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.076207 | 1.118 |
| R-HSA-418597 | G alpha (z) signalling events | 0.076231 | 1.118 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.086815 | 1.061 |
| R-HSA-112043 | PLC beta mediated events | 0.088983 | 1.051 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.063320 | 1.198 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.082842 | 1.082 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.082842 | 1.082 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.091167 | 1.040 |
| R-HSA-195721 | Signaling by WNT | 0.080688 | 1.093 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.068088 | 1.167 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.070095 | 1.154 |
| R-HSA-68875 | Mitotic Prophase | 0.073259 | 1.135 |
| R-HSA-373755 | Semaphorin interactions | 0.093366 | 1.030 |
| R-HSA-5357801 | Programmed Cell Death | 0.080342 | 1.095 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.070095 | 1.154 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.095581 | 1.020 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.095581 | 1.020 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.095972 | 1.018 |
| R-HSA-192905 | vRNP Assembly | 0.095972 | 1.018 |
| R-HSA-77108 | Utilization of Ketone Bodies | 0.095972 | 1.018 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.102466 | 0.989 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.108915 | 0.963 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.146652 | 0.834 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.146652 | 0.834 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.146652 | 0.834 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.152786 | 0.816 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.158876 | 0.799 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.170926 | 0.767 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.170926 | 0.767 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.170926 | 0.767 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.170926 | 0.767 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.194515 | 0.711 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.147572 | 0.831 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.147572 | 0.831 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.104587 | 0.981 |
| R-HSA-157579 | Telomere Maintenance | 0.183050 | 0.737 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.127986 | 0.893 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.140475 | 0.852 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.200307 | 0.698 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.170111 | 0.769 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.102314 | 0.990 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.190814 | 0.719 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.108915 | 0.963 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.152786 | 0.816 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.182805 | 0.738 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.194515 | 0.711 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.135282 | 0.869 |
| R-HSA-167172 | Transcription of the HIV genome | 0.104587 | 0.981 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.118504 | 0.926 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.102466 | 0.989 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.102466 | 0.989 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.134253 | 0.872 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.140475 | 0.852 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.140475 | 0.852 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.152786 | 0.816 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.170926 | 0.767 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.200307 | 0.698 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.194515 | 0.711 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.108915 | 0.963 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.140475 | 0.852 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.152786 | 0.816 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.102466 | 0.989 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.108915 | 0.963 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 0.121674 | 0.915 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 0.121674 | 0.915 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 0.121674 | 0.915 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 0.127986 | 0.893 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.188681 | 0.724 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.132853 | 0.877 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 0.140475 | 0.852 |
| R-HSA-1500620 | Meiosis | 0.145096 | 0.838 |
| R-HSA-74182 | Ketone body metabolism | 0.188681 | 0.724 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.128026 | 0.893 |
| R-HSA-416476 | G alpha (q) signalling events | 0.149661 | 0.825 |
| R-HSA-71262 | Carnitine synthesis | 0.134253 | 0.872 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.146652 | 0.834 |
| R-HSA-5617833 | Cilium Assembly | 0.191730 | 0.717 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.121674 | 0.915 |
| R-HSA-1237112 | Methionine salvage pathway | 0.158876 | 0.799 |
| R-HSA-877300 | Interferon gamma signaling | 0.136264 | 0.866 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.175336 | 0.756 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 0.164922 | 0.783 |
| R-HSA-112040 | G-protein mediated events | 0.102314 | 0.990 |
| R-HSA-3214842 | HDMs demethylate histones | 0.200307 | 0.698 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.111998 | 0.951 |
| R-HSA-9610379 | HCMV Late Events | 0.133005 | 0.876 |
| R-HSA-8939211 | ESR-mediated signaling | 0.115552 | 0.937 |
| R-HSA-4839726 | Chromatin organization | 0.130254 | 0.885 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.123400 | 0.909 |
| R-HSA-111885 | Opioid Signalling | 0.201232 | 0.696 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.118504 | 0.926 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.108915 | 0.963 |
| R-HSA-9833482 | PKR-mediated signaling | 0.132853 | 0.877 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.163272 | 0.787 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.155018 | 0.810 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.200307 | 0.698 |
| R-HSA-73942 | DNA Damage Reversal | 0.127986 | 0.893 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.190814 | 0.719 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.121825 | 0.914 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.195374 | 0.709 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.150057 | 0.824 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.167678 | 0.776 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.165866 | 0.780 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.150057 | 0.824 |
| R-HSA-109581 | Apoptosis | 0.141203 | 0.850 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.137903 | 0.860 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.165138 | 0.782 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.130095 | 0.886 |
| R-HSA-5619102 | SLC transporter disorders | 0.149567 | 0.825 |
| R-HSA-9609690 | HCMV Early Events | 0.202713 | 0.693 |
| R-HSA-9833110 | RSV-host interactions | 0.203848 | 0.691 |
| R-HSA-9824446 | Viral Infection Pathways | 0.204860 | 0.689 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.206058 | 0.686 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.206058 | 0.686 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.209090 | 0.680 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.211716 | 0.674 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.211716 | 0.674 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.211769 | 0.674 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.211769 | 0.674 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.211769 | 0.674 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.216979 | 0.664 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.217438 | 0.663 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.217438 | 0.663 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.217438 | 0.663 |
| R-HSA-202403 | TCR signaling | 0.219615 | 0.658 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.223067 | 0.652 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.223067 | 0.652 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.228656 | 0.641 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.228656 | 0.641 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.228656 | 0.641 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.228656 | 0.641 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.228656 | 0.641 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.230185 | 0.638 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.234205 | 0.630 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.234205 | 0.630 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.238136 | 0.623 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.238136 | 0.623 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.239715 | 0.620 |
| R-HSA-68882 | Mitotic Anaphase | 0.242199 | 0.616 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.244113 | 0.612 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.245185 | 0.611 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.245185 | 0.611 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.245185 | 0.611 |
| R-HSA-5693538 | Homology Directed Repair | 0.246101 | 0.609 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.250616 | 0.601 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.250616 | 0.601 |
| R-HSA-73886 | Chromosome Maintenance | 0.254077 | 0.595 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.254077 | 0.595 |
| R-HSA-203615 | eNOS activation | 0.256008 | 0.592 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.256008 | 0.592 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.256008 | 0.592 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.261362 | 0.583 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.261362 | 0.583 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.261442 | 0.583 |
| R-HSA-6798695 | Neutrophil degranulation | 0.262303 | 0.581 |
| R-HSA-111933 | Calmodulin induced events | 0.266678 | 0.574 |
| R-HSA-111997 | CaM pathway | 0.266678 | 0.574 |
| R-HSA-194138 | Signaling by VEGF | 0.267382 | 0.573 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.271956 | 0.566 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.271956 | 0.566 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.271956 | 0.566 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.271956 | 0.566 |
| R-HSA-69481 | G2/M Checkpoints | 0.272705 | 0.564 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.273265 | 0.563 |
| R-HSA-168256 | Immune System | 0.273884 | 0.562 |
| R-HSA-8953854 | Metabolism of RNA | 0.275921 | 0.559 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.277196 | 0.557 |
| R-HSA-73927 | Depurination | 0.277196 | 0.557 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.277196 | 0.557 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.282399 | 0.549 |
| R-HSA-9648002 | RAS processing | 0.282399 | 0.549 |
| R-HSA-1474165 | Reproduction | 0.283347 | 0.548 |
| R-HSA-9843745 | Adipogenesis | 0.286006 | 0.544 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.287564 | 0.541 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.287564 | 0.541 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.287564 | 0.541 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.287564 | 0.541 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.287564 | 0.541 |
| R-HSA-202433 | Generation of second messenger molecules | 0.287564 | 0.541 |
| R-HSA-9646399 | Aggrephagy | 0.287564 | 0.541 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.287564 | 0.541 |
| R-HSA-9909396 | Circadian clock | 0.288664 | 0.540 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.292693 | 0.534 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.292693 | 0.534 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.292693 | 0.534 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.297785 | 0.526 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.297785 | 0.526 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.298294 | 0.525 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.302412 | 0.519 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.302841 | 0.519 |
| R-HSA-111996 | Ca-dependent events | 0.302841 | 0.519 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.302841 | 0.519 |
| R-HSA-73928 | Depyrimidination | 0.302841 | 0.519 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.307234 | 0.513 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.307861 | 0.512 |
| R-HSA-9609646 | HCMV Infection | 0.308302 | 0.511 |
| R-HSA-373752 | Netrin-1 signaling | 0.312845 | 0.505 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.315168 | 0.501 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.317793 | 0.498 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.317793 | 0.498 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.317793 | 0.498 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.322706 | 0.491 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.322706 | 0.491 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.322706 | 0.491 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.327584 | 0.485 |
| R-HSA-425410 | Metal ion SLC transporters | 0.332427 | 0.478 |
| R-HSA-73893 | DNA Damage Bypass | 0.337235 | 0.472 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.337235 | 0.472 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.341455 | 0.467 |
| R-HSA-912446 | Meiotic recombination | 0.346749 | 0.460 |
| R-HSA-2514856 | The phototransduction cascade | 0.346749 | 0.460 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.349285 | 0.457 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.351456 | 0.454 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.351888 | 0.454 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.356128 | 0.448 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.356128 | 0.448 |
| R-HSA-1221632 | Meiotic synapsis | 0.356128 | 0.448 |
| R-HSA-9612973 | Autophagy | 0.357084 | 0.447 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.360767 | 0.443 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.365373 | 0.437 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.365373 | 0.437 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.365373 | 0.437 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.369947 | 0.432 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.369947 | 0.432 |
| R-HSA-75893 | TNF signaling | 0.369947 | 0.432 |
| R-HSA-8935690 | Digestion | 0.369947 | 0.432 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.369947 | 0.432 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.369947 | 0.432 |
| R-HSA-1483166 | Synthesis of PA | 0.374487 | 0.427 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.377714 | 0.423 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.378995 | 0.421 |
| R-HSA-168249 | Innate Immune System | 0.380970 | 0.419 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.383471 | 0.416 |
| R-HSA-4085001 | Sialic acid metabolism | 0.383471 | 0.416 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.387915 | 0.411 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.387915 | 0.411 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.387915 | 0.411 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.389010 | 0.410 |
| R-HSA-9707616 | Heme signaling | 0.396707 | 0.402 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.396707 | 0.402 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.396707 | 0.402 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.400595 | 0.397 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.401057 | 0.397 |
| R-HSA-8963743 | Digestion and absorption | 0.401057 | 0.397 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.408136 | 0.389 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.413919 | 0.383 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.413919 | 0.383 |
| R-HSA-5218859 | Regulated Necrosis | 0.422341 | 0.374 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.430643 | 0.366 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.430643 | 0.366 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.434750 | 0.362 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.434750 | 0.362 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.434750 | 0.362 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.434750 | 0.362 |
| R-HSA-8978934 | Metabolism of cofactors | 0.434750 | 0.362 |
| R-HSA-597592 | Post-translational protein modification | 0.436256 | 0.360 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.438827 | 0.358 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.438827 | 0.358 |
| R-HSA-983712 | Ion channel transport | 0.442708 | 0.354 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.442875 | 0.354 |
| R-HSA-4086398 | Ca2+ pathway | 0.442875 | 0.354 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.444339 | 0.352 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.446894 | 0.350 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.447558 | 0.349 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.449992 | 0.347 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.450885 | 0.346 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.450885 | 0.346 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.454847 | 0.342 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.462686 | 0.335 |
| R-HSA-5663205 | Infectious disease | 0.464089 | 0.333 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.469089 | 0.329 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.469089 | 0.329 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.481798 | 0.317 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.485538 | 0.314 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.489252 | 0.310 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.489638 | 0.310 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.492940 | 0.307 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.492940 | 0.307 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.496600 | 0.304 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.496600 | 0.304 |
| R-HSA-9663891 | Selective autophagy | 0.503844 | 0.298 |
| R-HSA-202424 | Downstream TCR signaling | 0.510984 | 0.292 |
| R-HSA-73884 | Base Excision Repair | 0.510984 | 0.292 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.528392 | 0.277 |
| R-HSA-199991 | Membrane Trafficking | 0.530393 | 0.275 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.538540 | 0.269 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.538540 | 0.269 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.541875 | 0.266 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.545185 | 0.263 |
| R-HSA-422356 | Regulation of insulin secretion | 0.545185 | 0.263 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.554975 | 0.256 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.558192 | 0.253 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.564556 | 0.248 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.564556 | 0.248 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.570766 | 0.244 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.570830 | 0.243 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.570830 | 0.243 |
| R-HSA-74160 | Gene expression (Transcription) | 0.579818 | 0.237 |
| R-HSA-422475 | Axon guidance | 0.585172 | 0.233 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.586124 | 0.232 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.586124 | 0.232 |
| R-HSA-6803157 | Antimicrobial peptides | 0.589117 | 0.230 |
| R-HSA-1643685 | Disease | 0.591957 | 0.228 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.593117 | 0.227 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.597969 | 0.223 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.600878 | 0.221 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.606632 | 0.217 |
| R-HSA-373760 | L1CAM interactions | 0.609478 | 0.215 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.612304 | 0.213 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.623407 | 0.205 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.623407 | 0.205 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.627581 | 0.202 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.628839 | 0.201 |
| R-HSA-5668914 | Diseases of metabolism | 0.629327 | 0.201 |
| R-HSA-9675108 | Nervous system development | 0.635222 | 0.197 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.636842 | 0.196 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.636842 | 0.196 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.636842 | 0.196 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.640366 | 0.194 |
| R-HSA-9658195 | Leishmania infection | 0.640366 | 0.194 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.642164 | 0.192 |
| R-HSA-5576891 | Cardiac conduction | 0.654857 | 0.184 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.654857 | 0.184 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.669591 | 0.174 |
| R-HSA-163685 | Integration of energy metabolism | 0.669591 | 0.174 |
| R-HSA-6807070 | PTEN Regulation | 0.676723 | 0.170 |
| R-HSA-1632852 | Macroautophagy | 0.681392 | 0.167 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.688271 | 0.162 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.690531 | 0.161 |
| R-HSA-2187338 | Visual phototransduction | 0.697214 | 0.157 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.699410 | 0.155 |
| R-HSA-212436 | Generic Transcription Pathway | 0.706599 | 0.151 |
| R-HSA-73887 | Death Receptor Signaling | 0.712257 | 0.147 |
| R-HSA-1989781 | PPARA activates gene expression | 0.714345 | 0.146 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.718475 | 0.144 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.718475 | 0.144 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.724560 | 0.140 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.736209 | 0.133 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.737607 | 0.132 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.745768 | 0.127 |
| R-HSA-418555 | G alpha (s) signalling events | 0.747622 | 0.126 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.747622 | 0.126 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.751275 | 0.124 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.751275 | 0.124 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.754876 | 0.122 |
| R-HSA-611105 | Respiratory electron transport | 0.760180 | 0.119 |
| R-HSA-2559583 | Cellular Senescence | 0.763653 | 0.117 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.766800 | 0.115 |
| R-HSA-3781865 | Diseases of glycosylation | 0.770449 | 0.113 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.786605 | 0.104 |
| R-HSA-1280218 | Adaptive Immune System | 0.787721 | 0.104 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.789698 | 0.103 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.790874 | 0.102 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.800179 | 0.097 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.800179 | 0.097 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.802157 | 0.096 |
| R-HSA-72172 | mRNA Splicing | 0.803077 | 0.095 |
| R-HSA-397014 | Muscle contraction | 0.814258 | 0.089 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.814258 | 0.089 |
| R-HSA-418594 | G alpha (i) signalling events | 0.816876 | 0.088 |
| R-HSA-8978868 | Fatty acid metabolism | 0.816876 | 0.088 |
| R-HSA-418990 | Adherens junctions interactions | 0.822229 | 0.085 |
| R-HSA-388396 | GPCR downstream signalling | 0.829696 | 0.081 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.831636 | 0.080 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.837167 | 0.077 |
| R-HSA-449147 | Signaling by Interleukins | 0.848527 | 0.071 |
| R-HSA-392499 | Metabolism of proteins | 0.851485 | 0.070 |
| R-HSA-382551 | Transport of small molecules | 0.854460 | 0.068 |
| R-HSA-421270 | Cell-cell junction organization | 0.860375 | 0.065 |
| R-HSA-5688426 | Deubiquitination | 0.864408 | 0.063 |
| R-HSA-112316 | Neuronal System | 0.870488 | 0.060 |
| R-HSA-372790 | Signaling by GPCR | 0.882450 | 0.054 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.885456 | 0.053 |
| R-HSA-446728 | Cell junction organization | 0.885456 | 0.053 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.894343 | 0.048 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.898898 | 0.046 |
| R-HSA-1483257 | Phospholipid metabolism | 0.898898 | 0.046 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.899639 | 0.046 |
| R-HSA-1500931 | Cell-Cell communication | 0.913363 | 0.039 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.917713 | 0.037 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.931047 | 0.031 |
| R-HSA-109582 | Hemostasis | 0.933286 | 0.030 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.945497 | 0.024 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.951622 | 0.022 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.952683 | 0.021 |
| R-HSA-1430728 | Metabolism | 0.974476 | 0.011 |
| R-HSA-1266738 | Developmental Biology | 0.978092 | 0.010 |
| R-HSA-211859 | Biological oxidations | 0.981435 | 0.008 |
| R-HSA-556833 | Metabolism of lipids | 0.986938 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 0.988662 | 0.005 |
| R-HSA-9709957 | Sensory Perception | 0.999920 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.799 | 0.134 | -3 | 0.843 |
RSK2 |
0.798 | 0.155 | -3 | 0.795 |
HIPK4 |
0.797 | 0.155 | 1 | 0.832 |
NDR2 |
0.796 | 0.093 | -3 | 0.823 |
CLK3 |
0.795 | 0.130 | 1 | 0.828 |
COT |
0.793 | 0.019 | 2 | 0.541 |
PIM3 |
0.793 | 0.103 | -3 | 0.831 |
CDC7 |
0.792 | 0.104 | 1 | 0.771 |
PRKD2 |
0.791 | 0.107 | -3 | 0.796 |
CDKL5 |
0.791 | 0.123 | -3 | 0.814 |
P90RSK |
0.789 | 0.103 | -3 | 0.790 |
NDR1 |
0.788 | 0.086 | -3 | 0.830 |
CAMK1B |
0.788 | 0.078 | -3 | 0.869 |
RSK3 |
0.788 | 0.102 | -3 | 0.788 |
PAK6 |
0.787 | 0.254 | -2 | 0.687 |
PIM1 |
0.786 | 0.111 | -3 | 0.798 |
CDKL1 |
0.786 | 0.096 | -3 | 0.819 |
SRPK1 |
0.785 | 0.079 | -3 | 0.773 |
ERK5 |
0.783 | 0.065 | 1 | 0.831 |
WNK1 |
0.782 | 0.046 | -2 | 0.866 |
ICK |
0.782 | 0.129 | -3 | 0.846 |
PRPK |
0.782 | -0.054 | -1 | 0.790 |
NLK |
0.782 | 0.037 | 1 | 0.831 |
CAMK2D |
0.782 | 0.059 | -3 | 0.854 |
CAMK2G |
0.781 | 0.012 | 2 | 0.501 |
MOS |
0.781 | 0.037 | 1 | 0.838 |
LATS2 |
0.781 | 0.050 | -5 | 0.697 |
MAPKAPK2 |
0.780 | 0.068 | -3 | 0.763 |
MTOR |
0.780 | 0.013 | 1 | 0.765 |
P70S6KB |
0.780 | 0.078 | -3 | 0.814 |
CAMK2A |
0.780 | 0.101 | 2 | 0.492 |
RSK4 |
0.779 | 0.113 | -3 | 0.752 |
MAPKAPK3 |
0.779 | 0.050 | -3 | 0.801 |
SKMLCK |
0.778 | 0.024 | -2 | 0.830 |
NUAK2 |
0.778 | 0.019 | -3 | 0.839 |
CAMK2B |
0.777 | 0.072 | 2 | 0.490 |
GCN2 |
0.777 | -0.109 | 2 | 0.519 |
PKACG |
0.777 | 0.063 | -2 | 0.717 |
ATR |
0.777 | 0.034 | 1 | 0.804 |
PKN3 |
0.777 | 0.008 | -3 | 0.820 |
TBK1 |
0.777 | -0.045 | 1 | 0.701 |
PDHK4 |
0.777 | -0.095 | 1 | 0.817 |
DYRK2 |
0.776 | 0.095 | 1 | 0.740 |
TSSK1 |
0.776 | 0.052 | -3 | 0.860 |
AURC |
0.776 | 0.061 | -2 | 0.630 |
SRPK2 |
0.776 | 0.067 | -3 | 0.712 |
FAM20C |
0.776 | 0.006 | 2 | 0.378 |
TSSK2 |
0.776 | 0.030 | -5 | 0.792 |
NIM1 |
0.776 | 0.007 | 3 | 0.499 |
AMPKA1 |
0.776 | 0.053 | -3 | 0.850 |
PRKD3 |
0.775 | 0.074 | -3 | 0.783 |
RIPK3 |
0.775 | -0.062 | 3 | 0.498 |
CAMLCK |
0.775 | 0.027 | -2 | 0.820 |
MARK4 |
0.775 | -0.009 | 4 | 0.820 |
CHAK2 |
0.775 | 0.036 | -1 | 0.803 |
IKKB |
0.774 | -0.082 | -2 | 0.731 |
CDK8 |
0.774 | 0.087 | 1 | 0.703 |
PAK1 |
0.774 | 0.041 | -2 | 0.763 |
RAF1 |
0.774 | -0.108 | 1 | 0.791 |
AMPKA2 |
0.774 | 0.062 | -3 | 0.825 |
HUNK |
0.773 | -0.034 | 2 | 0.578 |
KIS |
0.773 | 0.038 | 1 | 0.733 |
NIK |
0.772 | -0.014 | -3 | 0.871 |
IKKE |
0.772 | -0.051 | 1 | 0.692 |
CDK19 |
0.772 | 0.088 | 1 | 0.667 |
PKN2 |
0.771 | -0.004 | -3 | 0.839 |
ULK2 |
0.771 | -0.140 | 2 | 0.495 |
PAK3 |
0.771 | 0.015 | -2 | 0.762 |
MSK1 |
0.771 | 0.068 | -3 | 0.774 |
PDHK1 |
0.771 | -0.133 | 1 | 0.814 |
JNK2 |
0.770 | 0.103 | 1 | 0.643 |
MASTL |
0.770 | -0.051 | -2 | 0.797 |
DAPK2 |
0.770 | 0.011 | -3 | 0.865 |
CLK2 |
0.770 | 0.104 | -3 | 0.766 |
MSK2 |
0.769 | 0.029 | -3 | 0.776 |
HIPK2 |
0.769 | 0.113 | 1 | 0.663 |
PKACB |
0.769 | 0.074 | -2 | 0.646 |
MST4 |
0.769 | -0.048 | 2 | 0.497 |
P38A |
0.768 | 0.117 | 1 | 0.745 |
CLK1 |
0.768 | 0.078 | -3 | 0.776 |
CDK7 |
0.768 | 0.066 | 1 | 0.710 |
DSTYK |
0.768 | -0.068 | 2 | 0.566 |
BMPR2 |
0.768 | -0.159 | -2 | 0.842 |
SRPK3 |
0.768 | 0.040 | -3 | 0.748 |
GRK6 |
0.768 | 0.028 | 1 | 0.749 |
GRK5 |
0.768 | -0.009 | -3 | 0.827 |
MELK |
0.767 | 0.008 | -3 | 0.821 |
PKCD |
0.767 | -0.033 | 2 | 0.454 |
CDK18 |
0.767 | 0.084 | 1 | 0.640 |
CLK4 |
0.767 | 0.065 | -3 | 0.787 |
LATS1 |
0.766 | 0.064 | -3 | 0.819 |
DYRK1A |
0.766 | 0.093 | 1 | 0.767 |
DYRK4 |
0.766 | 0.086 | 1 | 0.664 |
P38B |
0.766 | 0.122 | 1 | 0.669 |
PIM2 |
0.766 | 0.083 | -3 | 0.777 |
MLK1 |
0.766 | -0.099 | 2 | 0.501 |
WNK3 |
0.766 | -0.122 | 1 | 0.800 |
HIPK1 |
0.766 | 0.098 | 1 | 0.757 |
GRK1 |
0.765 | 0.012 | -2 | 0.732 |
PRKX |
0.765 | 0.094 | -3 | 0.693 |
NEK6 |
0.765 | -0.062 | -2 | 0.811 |
TTBK2 |
0.765 | -0.020 | 2 | 0.536 |
AKT2 |
0.765 | 0.071 | -3 | 0.725 |
MNK2 |
0.765 | 0.005 | -2 | 0.770 |
MLK2 |
0.765 | -0.037 | 2 | 0.521 |
PAK4 |
0.764 | 0.171 | -2 | 0.627 |
SGK3 |
0.764 | 0.067 | -3 | 0.777 |
QSK |
0.764 | 0.013 | 4 | 0.789 |
NEK7 |
0.764 | -0.111 | -3 | 0.813 |
IKKA |
0.764 | -0.036 | -2 | 0.725 |
JNK3 |
0.764 | 0.076 | 1 | 0.681 |
CAMK4 |
0.764 | -0.035 | -3 | 0.831 |
PKG2 |
0.763 | 0.049 | -2 | 0.657 |
BCKDK |
0.763 | -0.105 | -1 | 0.730 |
CHK1 |
0.763 | 0.036 | -3 | 0.820 |
CDK5 |
0.763 | 0.060 | 1 | 0.727 |
SIK |
0.763 | 0.017 | -3 | 0.792 |
GSK3B |
0.763 | 0.153 | 4 | 0.585 |
RIPK1 |
0.763 | -0.111 | 1 | 0.786 |
AURB |
0.762 | 0.021 | -2 | 0.625 |
IRE1 |
0.762 | -0.085 | 1 | 0.803 |
PKCB |
0.762 | -0.017 | 2 | 0.446 |
ERK1 |
0.762 | 0.086 | 1 | 0.667 |
CDK1 |
0.762 | 0.082 | 1 | 0.641 |
NEK9 |
0.761 | -0.085 | 2 | 0.542 |
BRSK1 |
0.761 | -0.025 | -3 | 0.807 |
NUAK1 |
0.761 | -0.014 | -3 | 0.800 |
QIK |
0.761 | -0.038 | -3 | 0.845 |
GSK3A |
0.761 | 0.163 | 4 | 0.594 |
TGFBR2 |
0.761 | -0.078 | -2 | 0.719 |
MNK1 |
0.761 | -0.007 | -2 | 0.773 |
BRSK2 |
0.761 | -0.044 | -3 | 0.830 |
DCAMKL1 |
0.761 | 0.045 | -3 | 0.799 |
CAMK1G |
0.761 | 0.023 | -3 | 0.791 |
DNAPK |
0.761 | 0.047 | 1 | 0.686 |
HIPK3 |
0.761 | 0.078 | 1 | 0.758 |
ULK1 |
0.760 | -0.151 | -3 | 0.780 |
PKR |
0.760 | -0.016 | 1 | 0.835 |
GRK4 |
0.759 | -0.031 | -2 | 0.756 |
PAK2 |
0.759 | -0.022 | -2 | 0.743 |
MPSK1 |
0.759 | 0.185 | 1 | 0.854 |
PKCG |
0.759 | -0.039 | 2 | 0.442 |
DLK |
0.758 | -0.075 | 1 | 0.767 |
PHKG1 |
0.758 | -0.044 | -3 | 0.836 |
MYLK4 |
0.758 | -0.004 | -2 | 0.735 |
ANKRD3 |
0.757 | -0.115 | 1 | 0.824 |
PAK5 |
0.757 | 0.124 | -2 | 0.619 |
SMG1 |
0.757 | 0.024 | 1 | 0.767 |
PKACA |
0.757 | 0.065 | -2 | 0.605 |
PKCZ |
0.757 | -0.034 | 2 | 0.486 |
MLK3 |
0.757 | -0.066 | 2 | 0.449 |
PKCA |
0.756 | -0.039 | 2 | 0.425 |
MEK1 |
0.756 | -0.043 | 2 | 0.552 |
PASK |
0.756 | 0.122 | -3 | 0.839 |
PKCH |
0.755 | -0.045 | 2 | 0.437 |
P70S6K |
0.755 | 0.041 | -3 | 0.744 |
CDK3 |
0.755 | 0.067 | 1 | 0.596 |
P38G |
0.755 | 0.079 | 1 | 0.567 |
DCAMKL2 |
0.755 | 0.012 | -3 | 0.824 |
CDK14 |
0.755 | 0.059 | 1 | 0.675 |
MARK3 |
0.755 | -0.024 | 4 | 0.747 |
DYRK1B |
0.755 | 0.071 | 1 | 0.681 |
P38D |
0.755 | 0.090 | 1 | 0.622 |
PLK3 |
0.754 | -0.025 | 2 | 0.504 |
VRK2 |
0.754 | -0.079 | 1 | 0.857 |
ERK2 |
0.754 | 0.038 | 1 | 0.696 |
CDK16 |
0.754 | 0.081 | 1 | 0.599 |
DYRK3 |
0.754 | 0.063 | 1 | 0.764 |
CDK10 |
0.754 | 0.070 | 1 | 0.665 |
MAPKAPK5 |
0.754 | -0.011 | -3 | 0.756 |
MAK |
0.754 | 0.165 | -2 | 0.849 |
CHAK1 |
0.754 | -0.060 | 2 | 0.507 |
AURA |
0.754 | 0.010 | -2 | 0.588 |
ATM |
0.754 | -0.044 | 1 | 0.734 |
CDK17 |
0.754 | 0.056 | 1 | 0.574 |
CDK9 |
0.753 | 0.020 | 1 | 0.687 |
SSTK |
0.753 | -0.021 | 4 | 0.780 |
SNRK |
0.753 | -0.128 | 2 | 0.428 |
WNK4 |
0.752 | -0.032 | -2 | 0.854 |
CAMK1D |
0.752 | 0.040 | -3 | 0.730 |
MARK2 |
0.752 | -0.040 | 4 | 0.714 |
CDK13 |
0.752 | 0.015 | 1 | 0.682 |
CDK2 |
0.752 | 0.013 | 1 | 0.703 |
IRE2 |
0.751 | -0.123 | 2 | 0.413 |
NEK2 |
0.751 | -0.075 | 2 | 0.526 |
ALK4 |
0.751 | -0.033 | -2 | 0.750 |
TLK2 |
0.750 | -0.039 | 1 | 0.792 |
TGFBR1 |
0.750 | -0.032 | -2 | 0.722 |
MOK |
0.749 | 0.138 | 1 | 0.785 |
BMPR1B |
0.749 | 0.006 | 1 | 0.689 |
MARK1 |
0.749 | -0.049 | 4 | 0.764 |
AKT1 |
0.749 | 0.038 | -3 | 0.737 |
PLK1 |
0.749 | -0.087 | -2 | 0.748 |
GRK7 |
0.749 | 0.027 | 1 | 0.683 |
MLK4 |
0.749 | -0.095 | 2 | 0.442 |
PLK4 |
0.748 | -0.107 | 2 | 0.433 |
PHKG2 |
0.747 | -0.039 | -3 | 0.814 |
JNK1 |
0.746 | 0.065 | 1 | 0.621 |
YSK4 |
0.746 | -0.102 | 1 | 0.723 |
SGK1 |
0.746 | 0.076 | -3 | 0.653 |
ERK7 |
0.746 | -0.007 | 2 | 0.319 |
CDK12 |
0.746 | 0.016 | 1 | 0.653 |
IRAK4 |
0.746 | -0.070 | 1 | 0.805 |
PERK |
0.744 | -0.090 | -2 | 0.786 |
GAK |
0.744 | 0.117 | 1 | 0.850 |
SMMLCK |
0.744 | -0.013 | -3 | 0.833 |
AKT3 |
0.744 | 0.060 | -3 | 0.671 |
MRCKA |
0.744 | 0.078 | -3 | 0.775 |
TTBK1 |
0.743 | -0.067 | 2 | 0.461 |
PKCT |
0.743 | -0.056 | 2 | 0.438 |
SBK |
0.743 | 0.067 | -3 | 0.629 |
PKCI |
0.743 | -0.047 | 2 | 0.449 |
CK1E |
0.743 | -0.013 | -3 | 0.535 |
MRCKB |
0.742 | 0.067 | -3 | 0.765 |
MST3 |
0.742 | -0.017 | 2 | 0.525 |
DRAK1 |
0.742 | -0.088 | 1 | 0.645 |
PRP4 |
0.742 | -0.009 | -3 | 0.692 |
MEK5 |
0.741 | -0.144 | 2 | 0.525 |
PKCE |
0.741 | -0.015 | 2 | 0.430 |
ALK2 |
0.740 | -0.052 | -2 | 0.725 |
HRI |
0.740 | -0.121 | -2 | 0.806 |
CAMK1A |
0.740 | 0.035 | -3 | 0.704 |
TLK1 |
0.740 | -0.080 | -2 | 0.759 |
PINK1 |
0.739 | -0.082 | 1 | 0.874 |
MEKK1 |
0.739 | -0.105 | 1 | 0.791 |
NEK5 |
0.739 | -0.084 | 1 | 0.823 |
PKN1 |
0.739 | -0.004 | -3 | 0.764 |
BRAF |
0.739 | -0.094 | -4 | 0.816 |
DAPK3 |
0.738 | 0.024 | -3 | 0.812 |
MEKK2 |
0.738 | -0.098 | 2 | 0.518 |
CK1G1 |
0.738 | -0.030 | -3 | 0.509 |
ACVR2B |
0.738 | -0.053 | -2 | 0.732 |
ACVR2A |
0.737 | -0.063 | -2 | 0.722 |
ROCK2 |
0.737 | 0.062 | -3 | 0.795 |
CK2A2 |
0.737 | 0.028 | 1 | 0.624 |
ZAK |
0.737 | -0.113 | 1 | 0.733 |
MEKK3 |
0.736 | -0.144 | 1 | 0.748 |
CHK2 |
0.736 | 0.024 | -3 | 0.687 |
PLK2 |
0.736 | 0.030 | -3 | 0.776 |
DAPK1 |
0.735 | 0.024 | -3 | 0.799 |
GRK2 |
0.735 | -0.057 | -2 | 0.654 |
DMPK1 |
0.735 | 0.087 | -3 | 0.783 |
BUB1 |
0.734 | 0.044 | -5 | 0.753 |
CDK6 |
0.733 | 0.019 | 1 | 0.669 |
LKB1 |
0.733 | -0.029 | -3 | 0.801 |
CRIK |
0.733 | 0.083 | -3 | 0.735 |
CAMKK2 |
0.733 | -0.043 | -2 | 0.770 |
CDK4 |
0.732 | 0.025 | 1 | 0.644 |
PDK1 |
0.732 | -0.026 | 1 | 0.776 |
MEKK6 |
0.732 | -0.041 | 1 | 0.772 |
TAO3 |
0.732 | -0.070 | 1 | 0.748 |
PBK |
0.732 | 0.071 | 1 | 0.814 |
CK1A2 |
0.731 | -0.014 | -3 | 0.490 |
IRAK1 |
0.731 | -0.172 | -1 | 0.676 |
BMPR1A |
0.731 | -0.034 | 1 | 0.669 |
STK33 |
0.731 | -0.075 | 2 | 0.419 |
CAMKK1 |
0.731 | -0.085 | -2 | 0.756 |
YANK3 |
0.730 | -0.001 | 2 | 0.284 |
CK2A1 |
0.730 | 0.026 | 1 | 0.591 |
LRRK2 |
0.729 | -0.051 | 2 | 0.534 |
NEK11 |
0.728 | -0.132 | 1 | 0.742 |
PKG1 |
0.727 | 0.019 | -2 | 0.574 |
EEF2K |
0.727 | -0.071 | 3 | 0.500 |
CK1D |
0.727 | -0.033 | -3 | 0.486 |
TAO2 |
0.726 | -0.110 | 2 | 0.513 |
NEK4 |
0.726 | -0.102 | 1 | 0.774 |
MAP3K15 |
0.726 | -0.074 | 1 | 0.727 |
LOK |
0.726 | -0.054 | -2 | 0.777 |
TAK1 |
0.724 | -0.042 | 1 | 0.808 |
TNIK |
0.724 | -0.040 | 3 | 0.516 |
NEK8 |
0.724 | -0.168 | 2 | 0.500 |
GCK |
0.723 | -0.050 | 1 | 0.744 |
HGK |
0.723 | -0.076 | 3 | 0.518 |
VRK1 |
0.723 | -0.090 | 2 | 0.522 |
ROCK1 |
0.722 | 0.034 | -3 | 0.776 |
GRK3 |
0.722 | -0.049 | -2 | 0.594 |
NEK1 |
0.722 | -0.073 | 1 | 0.788 |
MINK |
0.720 | -0.079 | 1 | 0.759 |
PDHK3_TYR |
0.720 | 0.167 | 4 | 0.900 |
HPK1 |
0.719 | -0.051 | 1 | 0.720 |
KHS1 |
0.718 | -0.034 | 1 | 0.744 |
MST2 |
0.718 | -0.130 | 1 | 0.754 |
MEK2 |
0.718 | -0.114 | 2 | 0.544 |
SLK |
0.717 | -0.078 | -2 | 0.720 |
YSK1 |
0.715 | -0.086 | 2 | 0.508 |
BIKE |
0.715 | 0.062 | 1 | 0.769 |
KHS2 |
0.714 | -0.051 | 1 | 0.747 |
RIPK2 |
0.712 | -0.213 | 1 | 0.696 |
MST1 |
0.712 | -0.125 | 1 | 0.743 |
HASPIN |
0.712 | -0.019 | -1 | 0.643 |
NEK3 |
0.708 | -0.147 | 1 | 0.758 |
LIMK2_TYR |
0.706 | 0.010 | -3 | 0.874 |
PKMYT1_TYR |
0.706 | -0.026 | 3 | 0.556 |
MAP2K4_TYR |
0.705 | -0.005 | -1 | 0.811 |
AAK1 |
0.705 | 0.094 | 1 | 0.687 |
TESK1_TYR |
0.704 | -0.095 | 3 | 0.566 |
TTK |
0.704 | -0.083 | -2 | 0.757 |
MAP2K6_TYR |
0.704 | -0.019 | -1 | 0.808 |
PDHK4_TYR |
0.703 | -0.036 | 2 | 0.514 |
MYO3B |
0.702 | -0.081 | 2 | 0.502 |
MAP2K7_TYR |
0.701 | -0.150 | 2 | 0.535 |
ASK1 |
0.701 | -0.110 | 1 | 0.711 |
OSR1 |
0.700 | -0.118 | 2 | 0.507 |
BMPR2_TYR |
0.700 | -0.005 | -1 | 0.804 |
PDHK1_TYR |
0.700 | -0.044 | -1 | 0.820 |
EPHA6 |
0.698 | -0.035 | -1 | 0.802 |
DDR1 |
0.696 | -0.056 | 4 | 0.821 |
PINK1_TYR |
0.696 | -0.160 | 1 | 0.805 |
MYO3A |
0.695 | -0.107 | 1 | 0.757 |
ALPHAK3 |
0.695 | -0.096 | -1 | 0.709 |
CK1A |
0.695 | -0.046 | -3 | 0.392 |
LIMK1_TYR |
0.694 | -0.128 | 2 | 0.527 |
YANK2 |
0.693 | -0.024 | 2 | 0.288 |
EPHB4 |
0.693 | -0.065 | -1 | 0.772 |
TAO1 |
0.693 | -0.136 | 1 | 0.694 |
TNK2 |
0.693 | -0.044 | 3 | 0.465 |
RET |
0.691 | -0.150 | 1 | 0.774 |
YES1 |
0.690 | -0.032 | -1 | 0.803 |
ABL2 |
0.689 | -0.045 | -1 | 0.750 |
ABL1 |
0.689 | -0.031 | -1 | 0.748 |
FGR |
0.687 | -0.050 | 1 | 0.818 |
EPHA4 |
0.687 | -0.064 | 2 | 0.486 |
MST1R |
0.687 | -0.184 | 3 | 0.491 |
TXK |
0.686 | -0.016 | 1 | 0.749 |
DDR2 |
0.686 | -0.024 | 3 | 0.466 |
ROS1 |
0.685 | -0.184 | 3 | 0.450 |
TNK1 |
0.684 | -0.096 | 3 | 0.464 |
TYRO3 |
0.684 | -0.202 | 3 | 0.463 |
JAK2 |
0.684 | -0.188 | 1 | 0.778 |
TYK2 |
0.684 | -0.220 | 1 | 0.781 |
STLK3 |
0.683 | -0.155 | 1 | 0.698 |
CSF1R |
0.683 | -0.156 | 3 | 0.468 |
FGFR2 |
0.682 | -0.143 | 3 | 0.523 |
BLK |
0.681 | -0.018 | -1 | 0.785 |
TNNI3K_TYR |
0.681 | -0.086 | 1 | 0.831 |
INSRR |
0.681 | -0.150 | 3 | 0.456 |
ITK |
0.681 | -0.091 | -1 | 0.734 |
JAK3 |
0.680 | -0.153 | 1 | 0.744 |
FER |
0.680 | -0.133 | 1 | 0.811 |
HCK |
0.680 | -0.101 | -1 | 0.776 |
SRMS |
0.679 | -0.117 | 1 | 0.766 |
EPHB1 |
0.679 | -0.108 | 1 | 0.761 |
EPHB2 |
0.679 | -0.090 | -1 | 0.746 |
EPHB3 |
0.679 | -0.119 | -1 | 0.755 |
LCK |
0.678 | -0.059 | -1 | 0.776 |
AXL |
0.677 | -0.145 | 3 | 0.471 |
MERTK |
0.676 | -0.122 | 3 | 0.475 |
KDR |
0.676 | -0.161 | 3 | 0.459 |
NEK10_TYR |
0.676 | -0.138 | 1 | 0.657 |
FYN |
0.675 | -0.026 | -1 | 0.766 |
LTK |
0.675 | -0.130 | 3 | 0.460 |
TEK |
0.674 | -0.203 | 3 | 0.433 |
EPHA7 |
0.674 | -0.101 | 2 | 0.491 |
PDGFRB |
0.674 | -0.217 | 3 | 0.473 |
EPHA3 |
0.674 | -0.119 | 2 | 0.470 |
FGFR1 |
0.673 | -0.199 | 3 | 0.464 |
JAK1 |
0.673 | -0.121 | 1 | 0.713 |
CK1G3 |
0.673 | -0.053 | -3 | 0.342 |
KIT |
0.672 | -0.180 | 3 | 0.477 |
PTK6 |
0.671 | -0.130 | -1 | 0.666 |
TEC |
0.671 | -0.092 | -1 | 0.704 |
BMX |
0.671 | -0.095 | -1 | 0.668 |
PTK2B |
0.670 | -0.092 | -1 | 0.732 |
ALK |
0.669 | -0.168 | 3 | 0.422 |
FLT3 |
0.669 | -0.221 | 3 | 0.455 |
PDGFRA |
0.668 | -0.234 | 3 | 0.467 |
BTK |
0.668 | -0.166 | -1 | 0.708 |
FGFR3 |
0.668 | -0.170 | 3 | 0.500 |
EPHA1 |
0.668 | -0.148 | 3 | 0.442 |
MET |
0.668 | -0.144 | 3 | 0.472 |
FLT1 |
0.667 | -0.132 | -1 | 0.757 |
SRC |
0.666 | -0.063 | -1 | 0.769 |
FLT4 |
0.666 | -0.190 | 3 | 0.484 |
LYN |
0.665 | -0.112 | 3 | 0.431 |
NTRK1 |
0.665 | -0.214 | -1 | 0.744 |
WEE1_TYR |
0.665 | -0.140 | -1 | 0.668 |
EPHA5 |
0.664 | -0.125 | 2 | 0.475 |
INSR |
0.664 | -0.178 | 3 | 0.440 |
ERBB2 |
0.662 | -0.186 | 1 | 0.697 |
EPHA8 |
0.662 | -0.119 | -1 | 0.741 |
FRK |
0.661 | -0.151 | -1 | 0.782 |
CSK |
0.661 | -0.122 | 2 | 0.498 |
PTK2 |
0.660 | -0.054 | -1 | 0.749 |
CK1G2 |
0.659 | -0.049 | -3 | 0.431 |
NTRK2 |
0.659 | -0.222 | 3 | 0.451 |
NTRK3 |
0.657 | -0.168 | -1 | 0.697 |
EGFR |
0.654 | -0.114 | 1 | 0.598 |
FGFR4 |
0.654 | -0.136 | -1 | 0.694 |
MATK |
0.653 | -0.150 | -1 | 0.663 |
EPHA2 |
0.651 | -0.136 | -1 | 0.705 |
IGF1R |
0.650 | -0.168 | 3 | 0.411 |
SYK |
0.646 | -0.087 | -1 | 0.713 |
ERBB4 |
0.644 | -0.114 | 1 | 0.598 |
MUSK |
0.638 | -0.187 | 1 | 0.592 |
FES |
0.635 | -0.167 | -1 | 0.649 |
ZAP70 |
0.621 | -0.119 | -1 | 0.636 |