Motif 498 (n=139)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S464 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| F5H5P2 | None | S381 | ochoa | 2-oxoisovalerate dehydrogenase subunit alpha (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) | Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000256|ARBA:ARBA00037052, ECO:0000256|RuleBase:RU365014}. |
| H0YHG0 | None | S475 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| H0YJW9 | None | S22 | ochoa | Uncharacterized protein | None |
| H3BTX0 | None | S64 | ochoa | PAXIP1-associated glutamate-rich protein 1 | None |
| O00571 | DDX3X | S28 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14490 | DLGAP1 | S419 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14523 | C2CD2L | S613 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14523 | C2CD2L | S623 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O15055 | PER2 | S662 | psp | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15516 | CLOCK | S431 | psp | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O43815 | STRN | S373 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60664 | PLIN3 | S375 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60716 | CTNND1 | S346 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60716 | CTNND1 | S899 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75473 | LGR5 | S848 | ochoa|psp | Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}. |
| O94875 | SORBS2 | S239 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95251 | KAT7 | S158 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| P02765 | AHSG | S325 | ochoa | Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B] | Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. |
| P04004 | VTN | S364 | ochoa | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. |
| P04004 | VTN | S403 | ochoa | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. |
| P07949 | RET | Y826 | psp | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P10451 | SPP1 | S228 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P12694 | BCKDHA | S347 | ochoa|psp | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) | Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:7883996, ECO:0000269|PubMed:9582350}. |
| P12830 | CDH1 | S844 | psp | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
| P16144 | ITGB4 | S1209 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16144 | ITGB4 | S1515 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16220 | CREB1 | S94 | psp | Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}. |
| P19174 | PLCG1 | S1227 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P20700 | LMNB1 | S395 | ochoa|psp | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P22670 | RFX1 | S117 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P26045 | PTPN3 | S367 | ochoa | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P42229 | STAT5A | S774 | ochoa | Signal transducer and activator of transcription 5A | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:15534001}. |
| P42704 | LRPPRC | S1026 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P45974 | USP5 | S779 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46013 | MKI67 | S1980 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2463 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49810 | PSEN2 | S19 | ochoa|psp | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}. |
| P51114 | FXR1 | S423 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P53667 | LIMK1 | S307 | ochoa|psp | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. |
| P55196 | AFDN | S561 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55265 | ADAR | S605 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P78527 | PRKDC | S3015 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P82979 | SARNP | S162 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| Q00536 | CDK16 | S86 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q03188 | CENPC | S46 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04656 | ATP7A | S1460 | psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q04656 | ATP7A | S1473 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q05519 | SRSF11 | S209 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q07157 | TJP1 | S294 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S828 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S831 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12888 | TP53BP1 | S330 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1025 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13127 | REST | S1024 | psp | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q13136 | PPFIA1 | S688 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13177 | PAK2 | S36 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13426 | XRCC4 | S260 | ochoa|psp | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q13464 | ROCK1 | S1102 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13501 | SQSTM1 | S355 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13523 | PRP4K | S569 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13526 | PIN1 | S38 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13796 | SHROOM2 | S174 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13835 | PKP1 | S229 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q13950 | RUNX2 | S240 | ochoa | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14005 | IL16 | S1074 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14149 | MORC3 | S540 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14161 | GIT2 | S394 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14161 | GIT2 | S559 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q16825 | PTPN21 | S610 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q27J81 | INF2 | S586 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q4KMP7 | TBC1D10B | S282 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q5SW79 | CEP170 | S627 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SW79 | CEP170 | S1216 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5VT06 | CEP350 | S2484 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q6DN90 | IQSEC1 | S358 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6GQQ9 | OTUD7B | S57 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6IQ55 | TTBK2 | S419 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6P2E9 | EDC4 | S887 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P996 | PDXDC1 | S718 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q7Z2W4 | ZC3HAV1 | S498 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z6B7 | SRGAP1 | S407 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6B7 | SRGAP1 | S410 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z7G8 | VPS13B | S1812 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86T90 | KIAA1328 | S490 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86TC9 | MYPN | S613 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86V48 | LUZP1 | S381 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8IVT2 | MISP | S278 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8N163 | CCAR2 | S675 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N3U4 | STAG2 | S1058 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
| Q8N488 | RYBP | S127 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8N4S9 | MARVELD2 | S387 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8NDI1 | EHBP1 | S171 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8WUM0 | NUP133 | S489 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WWI1 | LMO7 | S873 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXG6 | MADD | S830 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q92614 | MYO18A | S98 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92614 | MYO18A | S2014 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92997 | DVL3 | S137 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96B97 | SH3KBP1 | S82 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96BY6 | DOCK10 | S1289 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96CC6 | RHBDF1 | S188 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96HC4 | PDLIM5 | S319 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JM2 | ZNF462 | S292 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96KP1 | EXOC2 | S426 | ochoa | Exocyst complex component 2 (Exocyst complex component Sec5) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000269|PubMed:12459492, ECO:0000269|PubMed:32639540}. |
| Q96RG2 | PASK | S953 | ochoa|psp | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RG2 | PASK | S1277 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96TC7 | RMDN3 | S221 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99661 | KIF2C | S106 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q9BSQ5 | CCM2 | S245 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BTA9 | WAC | S436 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BTK6 | PAGR1 | S234 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BUH8 | BEGAIN | S194 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BWF3 | RBM4 | S334 | ochoa | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9BXF6 | RAB11FIP5 | S361 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BZ29 | DOCK9 | S1252 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9BZL6 | PRKD2 | S200 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9C0D6 | FHDC1 | S654 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H3Q1 | CDC42EP4 | S309 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H8V3 | ECT2 | S883 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NRF8 | CTPS2 | S568 | ochoa|psp | CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2) | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339}. |
| Q9NRX5 | SERINC1 | S361 | ochoa | Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) | Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250|UniProtKB:Q7TNK0}. |
| Q9NW97 | TMEM51 | S157 | ochoa | Transmembrane protein 51 | None |
| Q9NYV4 | CDK12 | S253 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P278 | FNIP2 | S723 | ochoa | Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein) | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913, PubMed:36103527). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913, PubMed:36103527). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). {ECO:0000250|UniProtKB:Q80TD3, ECO:0000250|UniProtKB:Q8TF40, ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36103527}. |
| Q9P2D1 | CHD7 | S2272 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBC2 | EPS15L1 | S587 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UDT6 | CLIP2 | S170 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UID3 | VPS51 | S643 | ochoa | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}. |
| Q9ULD4 | BRPF3 | S959 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9UMX1 | SUFU | S346 | ochoa|psp | Suppressor of fused homolog (SUFUH) | Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:27234298, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24217340, PubMed:24311597). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:24311597, PubMed:28965847). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:24311597, PubMed:28965847). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:24311597, PubMed:28965847). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:24311597, PubMed:28965847). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z0P7, ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:10564661, ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:12068298, ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:15367681, ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:28965847}. |
| Q9Y294 | ASF1A | S172 | ochoa | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}. |
| Q9Y4G8 | RAPGEF2 | S1156 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y5S2 | CDC42BPB | S1677 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y6D5 | ARFGEF2 | S1511 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6R1 | SLC4A4 | S223 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| P17174 | GOT1 | S82 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| Q13163 | MAP2K5 | S139 | Sugiyama | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:Q62862, ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}. |
| P14598 | NCF1 | S288 | SIGNOR|EPSD|PSP | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-75153 | Apoptotic execution phase | 7.013525e-07 | 6.154 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.456419e-06 | 5.837 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.184814e-05 | 4.926 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.445400e-04 | 3.840 |
| R-HSA-109581 | Apoptosis | 2.387561e-04 | 3.622 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.615380e-04 | 3.118 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.615380e-04 | 3.118 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 9.421658e-04 | 3.026 |
| R-HSA-5357801 | Programmed Cell Death | 1.018828e-03 | 2.992 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 1.379972e-03 | 2.860 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.591144e-03 | 2.798 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.740603e-03 | 2.759 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 1.867335e-03 | 2.729 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.925801e-03 | 2.715 |
| R-HSA-9909396 | Circadian clock | 2.285094e-03 | 2.641 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.188193e-03 | 2.660 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 2.424746e-03 | 2.615 |
| R-HSA-177929 | Signaling by EGFR | 2.756185e-03 | 2.560 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 3.744655e-03 | 2.427 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 3.744655e-03 | 2.427 |
| R-HSA-162582 | Signal Transduction | 3.552212e-03 | 2.450 |
| R-HSA-182971 | EGFR downregulation | 4.644832e-03 | 2.333 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 4.504667e-03 | 2.346 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.387031e-03 | 2.358 |
| R-HSA-73887 | Death Receptor Signaling | 4.736022e-03 | 2.325 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 6.218710e-03 | 2.206 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.337776e-03 | 2.198 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 7.170352e-03 | 2.144 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 7.170352e-03 | 2.144 |
| R-HSA-9020591 | Interleukin-12 signaling | 7.135818e-03 | 2.147 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 8.183508e-03 | 2.087 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 8.421703e-03 | 2.075 |
| R-HSA-194138 | Signaling by VEGF | 8.832500e-03 | 2.054 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.072205e-03 | 2.042 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 9.984434e-03 | 2.001 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.038976e-02 | 1.983 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.158059e-02 | 1.936 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.158059e-02 | 1.936 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.158059e-02 | 1.936 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.122063e-02 | 1.950 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.282840e-02 | 1.892 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.373039e-02 | 1.862 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.294063e-02 | 1.888 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.424828e-02 | 1.846 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 1.772697e-02 | 1.751 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.772697e-02 | 1.751 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 1.772697e-02 | 1.751 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.836786e-02 | 1.736 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 1.836786e-02 | 1.736 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.708107e-02 | 1.767 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.145173e-02 | 1.669 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.988448e-02 | 1.701 |
| R-HSA-75893 | TNF signaling | 2.020616e-02 | 1.695 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.145173e-02 | 1.669 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.452577e-02 | 1.610 |
| R-HSA-373755 | Semaphorin interactions | 2.638224e-02 | 1.579 |
| R-HSA-186797 | Signaling by PDGF | 2.544483e-02 | 1.594 |
| R-HSA-9707616 | Heme signaling | 2.544483e-02 | 1.594 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.644730e-02 | 1.578 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.647308e-02 | 1.577 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 2.647308e-02 | 1.577 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 2.647308e-02 | 1.577 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 3.514184e-02 | 1.454 |
| R-HSA-167021 | PLC-gamma1 signalling | 4.373395e-02 | 1.359 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 4.373395e-02 | 1.359 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 4.373395e-02 | 1.359 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 4.373395e-02 | 1.359 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 5.225007e-02 | 1.282 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.225007e-02 | 1.282 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 5.225007e-02 | 1.282 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 6.905701e-02 | 1.161 |
| R-HSA-176417 | Phosphorylation of Emi1 | 6.905701e-02 | 1.161 |
| R-HSA-9907570 | Loss-of-function mutations in DLD cause MSUD3/DLDD | 6.905701e-02 | 1.161 |
| R-HSA-9865113 | Loss-of-function mutations in DBT cause MSUD2 | 6.905701e-02 | 1.161 |
| R-HSA-9645135 | STAT5 Activation | 7.734915e-02 | 1.112 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 7.734915e-02 | 1.112 |
| R-HSA-9865125 | Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | 7.734915e-02 | 1.112 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 7.734915e-02 | 1.112 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 7.734915e-02 | 1.112 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 8.556794e-02 | 1.068 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 8.556794e-02 | 1.068 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.371402e-02 | 1.028 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 9.371402e-02 | 1.028 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.371402e-02 | 1.028 |
| R-HSA-9613354 | Lipophagy | 1.017880e-01 | 0.992 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.017880e-01 | 0.992 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.017880e-01 | 0.992 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.097906e-01 | 0.959 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.097906e-01 | 0.959 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.097906e-01 | 0.959 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.255840e-01 | 0.901 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 1.333760e-01 | 0.875 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.333760e-01 | 0.875 |
| R-HSA-9859138 | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | 1.487537e-01 | 0.828 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.487537e-01 | 0.828 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.563407e-01 | 0.806 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.563407e-01 | 0.806 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.563407e-01 | 0.806 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.638605e-01 | 0.786 |
| R-HSA-8853659 | RET signaling | 5.723549e-02 | 1.242 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.787010e-01 | 0.748 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.932799e-01 | 0.714 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 7.436829e-02 | 1.129 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 2.004727e-01 | 0.698 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.239091e-02 | 1.490 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.675990e-02 | 1.435 |
| R-HSA-9766229 | Degradation of CDH1 | 9.289856e-02 | 1.032 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.763219e-02 | 1.322 |
| R-HSA-72187 | mRNA 3'-end processing | 1.012101e-01 | 0.995 |
| R-HSA-1221632 | Meiotic synapsis | 1.040252e-01 | 0.983 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.291660e-02 | 1.276 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.291660e-02 | 1.276 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.154931e-01 | 0.937 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.689883e-01 | 0.570 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.393052e-01 | 0.856 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.549110e-01 | 0.594 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.174833e-01 | 0.930 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.546835e-01 | 0.811 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.457079e-02 | 1.024 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.457079e-02 | 1.024 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.375734e-02 | 1.472 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 1.713137e-01 | 0.766 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.242953e-01 | 0.906 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.723549e-02 | 1.242 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.767373e-02 | 1.424 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.255840e-01 | 0.901 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.713137e-01 | 0.766 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.097906e-01 | 0.959 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.279305e-01 | 0.893 |
| R-HSA-191650 | Regulation of gap junction activity | 5.225007e-02 | 1.282 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 6.069087e-02 | 1.217 |
| R-HSA-199920 | CREB phosphorylation | 7.734915e-02 | 1.112 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.609243e-01 | 0.793 |
| R-HSA-418990 | Adherens junctions interactions | 6.355044e-02 | 1.197 |
| R-HSA-421270 | Cell-cell junction organization | 9.711557e-02 | 1.013 |
| R-HSA-164843 | 2-LTR circle formation | 1.097906e-01 | 0.959 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.638605e-01 | 0.786 |
| R-HSA-9664420 | Killing mechanisms | 1.638605e-01 | 0.786 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.787010e-01 | 0.748 |
| R-HSA-446728 | Cell junction organization | 5.225057e-02 | 1.282 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.373803e-02 | 1.472 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.490698e-01 | 0.604 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 9.354024e-02 | 1.029 |
| R-HSA-1500931 | Cell-Cell communication | 8.225577e-02 | 1.085 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.557685e-01 | 0.592 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.830922e-02 | 1.106 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.354923e-01 | 0.628 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 3.514184e-02 | 1.454 |
| R-HSA-75102 | C6 deamination of adenosine | 3.514184e-02 | 1.454 |
| R-HSA-198765 | Signalling to ERK5 | 3.514184e-02 | 1.454 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 4.373395e-02 | 1.359 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.225007e-02 | 1.282 |
| R-HSA-8866376 | Reelin signalling pathway | 6.069087e-02 | 1.217 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 6.905701e-02 | 1.161 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.017880e-01 | 0.992 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.097906e-01 | 0.959 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.255840e-01 | 0.901 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.255840e-01 | 0.901 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.333760e-01 | 0.875 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.969409e-02 | 1.401 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.787010e-01 | 0.748 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.860229e-01 | 0.730 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.860229e-01 | 0.730 |
| R-HSA-202433 | Generation of second messenger molecules | 6.684028e-02 | 1.175 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.563407e-01 | 0.806 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.723549e-02 | 1.242 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 2.490698e-01 | 0.604 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.333760e-01 | 0.875 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.146677e-01 | 0.668 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.689883e-01 | 0.570 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.286124e-01 | 0.641 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.260039e-02 | 1.371 |
| R-HSA-9020958 | Interleukin-21 signaling | 1.017880e-01 | 0.992 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.216711e-01 | 0.654 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.557685e-01 | 0.592 |
| R-HSA-68877 | Mitotic Prometaphase | 1.233256e-01 | 0.909 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.154931e-01 | 0.937 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.154840e-02 | 1.089 |
| R-HSA-1500620 | Meiosis | 2.024477e-01 | 0.694 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.216711e-01 | 0.654 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.816965e-02 | 1.317 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.423113e-01 | 0.616 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 9.371402e-02 | 1.028 |
| R-HSA-75072 | mRNA Editing | 1.017880e-01 | 0.992 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.097906e-01 | 0.959 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.177224e-01 | 0.929 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.713137e-01 | 0.766 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.860229e-01 | 0.730 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.076017e-01 | 0.683 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.076017e-01 | 0.683 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.354923e-01 | 0.628 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.423113e-01 | 0.616 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.648128e-01 | 0.577 |
| R-HSA-68882 | Mitotic Anaphase | 6.176583e-02 | 1.209 |
| R-HSA-8985947 | Interleukin-9 signaling | 9.371402e-02 | 1.028 |
| R-HSA-9664873 | Pexophagy | 1.097906e-01 | 0.959 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.186311e-02 | 1.497 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.265451e-02 | 1.203 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 8.747545e-02 | 1.058 |
| R-HSA-9031628 | NGF-stimulated transcription | 9.017479e-02 | 1.045 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.333760e-01 | 0.875 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.609243e-01 | 0.793 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.863085e-01 | 0.730 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.076017e-01 | 0.683 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.689883e-01 | 0.570 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.681140e-01 | 0.572 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.816965e-02 | 1.317 |
| R-HSA-3928664 | Ephrin signaling | 1.860229e-01 | 0.730 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.491655e-02 | 1.260 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 6.931995e-02 | 1.159 |
| R-HSA-3214847 | HATs acetylate histones | 7.668999e-02 | 1.115 |
| R-HSA-2586552 | Signaling by Leptin | 1.097906e-01 | 0.959 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.177224e-01 | 0.929 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.017880e-01 | 0.992 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.097906e-01 | 0.959 |
| R-HSA-425381 | Bicarbonate transporters | 1.177224e-01 | 0.929 |
| R-HSA-428540 | Activation of RAC1 | 1.255840e-01 | 0.901 |
| R-HSA-186763 | Downstream signal transduction | 4.385476e-02 | 1.358 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.563407e-01 | 0.806 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.563407e-01 | 0.806 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.905219e-02 | 1.408 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.012101e-01 | 0.995 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.490698e-01 | 0.604 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.557685e-01 | 0.592 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.272648e-01 | 0.895 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.969409e-02 | 1.401 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.675990e-02 | 1.435 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.017880e-01 | 0.992 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.333760e-01 | 0.875 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.668999e-02 | 1.115 |
| R-HSA-9663891 | Selective autophagy | 2.154715e-01 | 0.667 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.978651e-01 | 0.704 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 6.905701e-02 | 1.161 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 6.905701e-02 | 1.161 |
| R-HSA-164944 | Nef and signal transduction | 7.734915e-02 | 1.112 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.017880e-01 | 0.992 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.017880e-01 | 0.992 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.487537e-01 | 0.828 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.487537e-01 | 0.828 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.563407e-01 | 0.806 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.004727e-01 | 0.698 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.354923e-01 | 0.628 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 9.530325e-02 | 1.021 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.799061e-01 | 0.745 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 1.955960e-01 | 0.709 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.789711e-02 | 1.421 |
| R-HSA-8852135 | Protein ubiquitination | 3.905219e-02 | 1.408 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.624078e-01 | 0.581 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.689883e-01 | 0.570 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.263206e-02 | 1.279 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.787010e-01 | 0.748 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.286124e-01 | 0.641 |
| R-HSA-449836 | Other interleukin signaling | 1.932799e-01 | 0.714 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.026124e-02 | 1.395 |
| R-HSA-422475 | Axon guidance | 3.146523e-02 | 1.502 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.410990e-01 | 0.850 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.410990e-01 | 0.850 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.638605e-01 | 0.786 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.787010e-01 | 0.748 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.787010e-01 | 0.748 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.004727e-01 | 0.698 |
| R-HSA-9675108 | Nervous system development | 4.508198e-02 | 1.346 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.146677e-01 | 0.668 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.097906e-01 | 0.959 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.076017e-01 | 0.683 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.216711e-01 | 0.654 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.354923e-01 | 0.628 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 6.684028e-02 | 1.175 |
| R-HSA-166520 | Signaling by NTRKs | 6.273335e-02 | 1.203 |
| R-HSA-210990 | PECAM1 interactions | 1.177224e-01 | 0.929 |
| R-HSA-162592 | Integration of provirus | 1.255840e-01 | 0.901 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.487537e-01 | 0.828 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.487537e-01 | 0.828 |
| R-HSA-1237112 | Methionine salvage pathway | 1.932799e-01 | 0.714 |
| R-HSA-1489509 | DAG and IP3 signaling | 8.215267e-02 | 1.085 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.146677e-01 | 0.668 |
| R-HSA-9830674 | Formation of the ureteric bud | 2.286124e-01 | 0.641 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.490698e-01 | 0.604 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.490698e-01 | 0.604 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.557685e-01 | 0.592 |
| R-HSA-199991 | Membrane Trafficking | 1.465253e-01 | 0.834 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.453932e-02 | 1.462 |
| R-HSA-168249 | Innate Immune System | 1.512886e-01 | 0.820 |
| R-HSA-3000170 | Syndecan interactions | 2.820716e-02 | 1.550 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.860229e-01 | 0.730 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.216711e-01 | 0.654 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.076017e-01 | 0.683 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.076017e-01 | 0.683 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.689883e-01 | 0.570 |
| R-HSA-74160 | Gene expression (Transcription) | 1.728487e-01 | 0.762 |
| R-HSA-216083 | Integrin cell surface interactions | 4.262396e-02 | 1.370 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.410990e-01 | 0.850 |
| R-HSA-977347 | Serine metabolism | 2.146677e-01 | 0.668 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 2.286124e-01 | 0.641 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.557685e-01 | 0.592 |
| R-HSA-212436 | Generic Transcription Pathway | 2.409169e-01 | 0.618 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.345607e-02 | 1.476 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.689883e-01 | 0.570 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.362718e-01 | 0.866 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.252899e-01 | 0.647 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.934980e-01 | 0.713 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 7.953056e-02 | 1.099 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.638605e-01 | 0.786 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.932799e-01 | 0.714 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.302510e-01 | 0.885 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.024477e-01 | 0.694 |
| R-HSA-9830364 | Formation of the nephric duct | 3.186311e-02 | 1.497 |
| R-HSA-168256 | Immune System | 1.594577e-01 | 0.797 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 9.371402e-02 | 1.028 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.017880e-01 | 0.992 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.490698e-01 | 0.604 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.672107e-01 | 0.777 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.384701e-01 | 0.623 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.515670e-01 | 0.599 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.860229e-01 | 0.730 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.932799e-01 | 0.714 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.354923e-01 | 0.628 |
| R-HSA-2559583 | Cellular Senescence | 2.635364e-01 | 0.579 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.578201e-01 | 0.589 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.949021e-02 | 1.158 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.146677e-01 | 0.668 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.910777e-01 | 0.719 |
| R-HSA-9830369 | Kidney development | 1.454158e-01 | 0.837 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.819807e-01 | 0.740 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.557685e-01 | 0.592 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.490698e-01 | 0.604 |
| R-HSA-449147 | Signaling by Interleukins | 2.225509e-01 | 0.653 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.936828e-01 | 0.713 |
| R-HSA-3000157 | Laminin interactions | 2.423113e-01 | 0.616 |
| R-HSA-2262752 | Cellular responses to stress | 8.244686e-02 | 1.084 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 9.017479e-02 | 1.045 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.703699e-01 | 0.769 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.125962e-01 | 0.948 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.490698e-01 | 0.604 |
| R-HSA-264876 | Insulin processing | 2.557685e-01 | 0.592 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 5.263206e-02 | 1.279 |
| R-HSA-4839726 | Chromatin organization | 2.213721e-01 | 0.655 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.286124e-01 | 0.641 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.938636e-02 | 1.003 |
| R-HSA-8854691 | Interleukin-20 family signaling | 2.286124e-01 | 0.641 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.076017e-01 | 0.683 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.286124e-01 | 0.641 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.354923e-01 | 0.628 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.354923e-01 | 0.628 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.557685e-01 | 0.592 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.910777e-01 | 0.719 |
| R-HSA-2028269 | Signaling by Hippo | 1.787010e-01 | 0.748 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.097780e-02 | 1.149 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.516120e-01 | 0.599 |
| R-HSA-112316 | Neuronal System | 2.738634e-01 | 0.562 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.747160e-01 | 0.561 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.755105e-01 | 0.560 |
| R-HSA-2424491 | DAP12 signaling | 2.755105e-01 | 0.560 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.755105e-01 | 0.560 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.755105e-01 | 0.560 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.755105e-01 | 0.560 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.794552e-01 | 0.554 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.813156e-01 | 0.551 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.819749e-01 | 0.550 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.819749e-01 | 0.550 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.819749e-01 | 0.550 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 2.819749e-01 | 0.550 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.819749e-01 | 0.550 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.819749e-01 | 0.550 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.883820e-01 | 0.540 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.912060e-01 | 0.536 |
| R-HSA-68886 | M Phase | 2.933105e-01 | 0.533 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.944994e-01 | 0.531 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.947323e-01 | 0.531 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.947323e-01 | 0.531 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.947323e-01 | 0.531 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.947323e-01 | 0.531 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.947323e-01 | 0.531 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.947323e-01 | 0.531 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.947323e-01 | 0.531 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.947323e-01 | 0.531 |
| R-HSA-913531 | Interferon Signaling | 2.950405e-01 | 0.530 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.977909e-01 | 0.526 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.977909e-01 | 0.526 |
| R-HSA-202403 | TCR signaling | 2.977909e-01 | 0.526 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.010264e-01 | 0.521 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.010264e-01 | 0.521 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.010264e-01 | 0.521 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.010264e-01 | 0.521 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 3.043667e-01 | 0.517 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.043667e-01 | 0.517 |
| R-HSA-1266738 | Developmental Biology | 3.056976e-01 | 0.515 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.072647e-01 | 0.512 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.072647e-01 | 0.512 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.072647e-01 | 0.512 |
| R-HSA-5205647 | Mitophagy | 3.072647e-01 | 0.512 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.076507e-01 | 0.512 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.119817e-01 | 0.506 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.134477e-01 | 0.504 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.134477e-01 | 0.504 |
| R-HSA-169911 | Regulation of Apoptosis | 3.134477e-01 | 0.504 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.134477e-01 | 0.504 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.134477e-01 | 0.504 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.142098e-01 | 0.503 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.174844e-01 | 0.498 |
| R-HSA-111933 | Calmodulin induced events | 3.195759e-01 | 0.495 |
| R-HSA-111997 | CaM pathway | 3.195759e-01 | 0.495 |
| R-HSA-163560 | Triglyceride catabolism | 3.195759e-01 | 0.495 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.207555e-01 | 0.494 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.239820e-01 | 0.489 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.256497e-01 | 0.487 |
| R-HSA-4641258 | Degradation of DVL | 3.256497e-01 | 0.487 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.256497e-01 | 0.487 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.272864e-01 | 0.485 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.305458e-01 | 0.481 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.316697e-01 | 0.479 |
| R-HSA-1566948 | Elastic fibre formation | 3.316697e-01 | 0.479 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.316697e-01 | 0.479 |
| R-HSA-68875 | Mitotic Prophase | 3.370515e-01 | 0.472 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.376364e-01 | 0.472 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.376364e-01 | 0.472 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.376364e-01 | 0.472 |
| R-HSA-201556 | Signaling by ALK | 3.376364e-01 | 0.472 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.376364e-01 | 0.472 |
| R-HSA-3371556 | Cellular response to heat stress | 3.402975e-01 | 0.468 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.402975e-01 | 0.468 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.435501e-01 | 0.464 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.435501e-01 | 0.464 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.435501e-01 | 0.464 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.435501e-01 | 0.464 |
| R-HSA-5260271 | Diseases of Immune System | 3.435501e-01 | 0.464 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.435501e-01 | 0.464 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.460958e-01 | 0.461 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.494114e-01 | 0.457 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.494114e-01 | 0.457 |
| R-HSA-9607240 | FLT3 Signaling | 3.494114e-01 | 0.457 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.500059e-01 | 0.456 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.552207e-01 | 0.450 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.552207e-01 | 0.450 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.552207e-01 | 0.450 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.552207e-01 | 0.450 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.552207e-01 | 0.450 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 3.596664e-01 | 0.444 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.609785e-01 | 0.443 |
| R-HSA-111996 | Ca-dependent events | 3.609785e-01 | 0.443 |
| R-HSA-114608 | Platelet degranulation | 3.628752e-01 | 0.440 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.666853e-01 | 0.436 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.666853e-01 | 0.436 |
| R-HSA-8854214 | TBC/RABGAPs | 3.666853e-01 | 0.436 |
| R-HSA-2172127 | DAP12 interactions | 3.723414e-01 | 0.429 |
| R-HSA-373752 | Netrin-1 signaling | 3.723414e-01 | 0.429 |
| R-HSA-1474165 | Reproduction | 3.756494e-01 | 0.425 |
| R-HSA-774815 | Nucleosome assembly | 3.779474e-01 | 0.423 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.779474e-01 | 0.423 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.779474e-01 | 0.423 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.779474e-01 | 0.423 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.779474e-01 | 0.423 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.779474e-01 | 0.423 |
| R-HSA-162906 | HIV Infection | 3.800690e-01 | 0.420 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 3.819980e-01 | 0.418 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.835036e-01 | 0.416 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.835036e-01 | 0.416 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.835036e-01 | 0.416 |
| R-HSA-1474244 | Extracellular matrix organization | 3.841661e-01 | 0.415 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.851622e-01 | 0.414 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.890106e-01 | 0.410 |
| R-HSA-437239 | Recycling pathway of L1 | 3.890106e-01 | 0.410 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.944687e-01 | 0.404 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.998784e-01 | 0.398 |
| R-HSA-8939211 | ESR-mediated signaling | 4.041189e-01 | 0.393 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.052401e-01 | 0.392 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.063358e-01 | 0.391 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 4.105542e-01 | 0.387 |
| R-HSA-1632852 | Macroautophagy | 4.133136e-01 | 0.384 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.163680e-01 | 0.381 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.210414e-01 | 0.376 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.210414e-01 | 0.376 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.210414e-01 | 0.376 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.225580e-01 | 0.374 |
| R-HSA-6798695 | Neutrophil degranulation | 4.254184e-01 | 0.371 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.262152e-01 | 0.370 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.284744e-01 | 0.368 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.313432e-01 | 0.365 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.313432e-01 | 0.365 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.364257e-01 | 0.360 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.364257e-01 | 0.360 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.377986e-01 | 0.359 |
| R-HSA-69242 | S Phase | 4.377986e-01 | 0.359 |
| R-HSA-9758941 | Gastrulation | 4.408208e-01 | 0.356 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.468388e-01 | 0.350 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.514040e-01 | 0.345 |
| R-HSA-191859 | snRNP Assembly | 4.514040e-01 | 0.345 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.514040e-01 | 0.345 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.514040e-01 | 0.345 |
| R-HSA-8979227 | Triglyceride metabolism | 4.514040e-01 | 0.345 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.514040e-01 | 0.345 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.557982e-01 | 0.341 |
| R-HSA-983189 | Kinesins | 4.563083e-01 | 0.341 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.563083e-01 | 0.341 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.563083e-01 | 0.341 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.563083e-01 | 0.341 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.563083e-01 | 0.341 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.563083e-01 | 0.341 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.563083e-01 | 0.341 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.563083e-01 | 0.341 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.563083e-01 | 0.341 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.611692e-01 | 0.336 |
| R-HSA-450294 | MAP kinase activation | 4.611692e-01 | 0.336 |
| R-HSA-112043 | PLC beta mediated events | 4.611692e-01 | 0.336 |
| R-HSA-9612973 | Autophagy | 4.617252e-01 | 0.336 |
| R-HSA-162587 | HIV Life Cycle | 4.646747e-01 | 0.333 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.659869e-01 | 0.332 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.659869e-01 | 0.332 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.659869e-01 | 0.332 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.659869e-01 | 0.332 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.734664e-01 | 0.325 |
| R-HSA-1640170 | Cell Cycle | 4.783569e-01 | 0.320 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.894411e-01 | 0.310 |
| R-HSA-112040 | G-protein mediated events | 4.894411e-01 | 0.310 |
| R-HSA-1643685 | Disease | 4.924705e-01 | 0.308 |
| R-HSA-5619102 | SLC transporter disorders | 4.936409e-01 | 0.307 |
| R-HSA-448424 | Interleukin-17 signaling | 5.030195e-01 | 0.298 |
| R-HSA-9658195 | Leishmania infection | 5.059355e-01 | 0.296 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.059355e-01 | 0.296 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.074655e-01 | 0.295 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.074655e-01 | 0.295 |
| R-HSA-3000178 | ECM proteoglycans | 5.074655e-01 | 0.295 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.074655e-01 | 0.295 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.074655e-01 | 0.295 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.118720e-01 | 0.291 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.118720e-01 | 0.291 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 5.118720e-01 | 0.291 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.133253e-01 | 0.290 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.133253e-01 | 0.290 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.160964e-01 | 0.287 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.162393e-01 | 0.287 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.162393e-01 | 0.287 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.205678e-01 | 0.284 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.205678e-01 | 0.284 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 5.205678e-01 | 0.284 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.235126e-01 | 0.281 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.291098e-01 | 0.276 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.364721e-01 | 0.270 |
| R-HSA-4086400 | PCP/CE pathway | 5.375007e-01 | 0.270 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.375007e-01 | 0.270 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.386128e-01 | 0.269 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.405664e-01 | 0.267 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.457430e-01 | 0.263 |
| R-HSA-9833482 | PKR-mediated signaling | 5.457430e-01 | 0.263 |
| R-HSA-6806834 | Signaling by MET | 5.457430e-01 | 0.263 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.498093e-01 | 0.260 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.498093e-01 | 0.260 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.538395e-01 | 0.257 |
| R-HSA-983712 | Ion channel transport | 5.564027e-01 | 0.255 |
| R-HSA-5617833 | Cilium Assembly | 5.590046e-01 | 0.253 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.615957e-01 | 0.251 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.657162e-01 | 0.247 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.693041e-01 | 0.245 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.696049e-01 | 0.244 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.734591e-01 | 0.241 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 5.734591e-01 | 0.241 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.734591e-01 | 0.241 |
| R-HSA-9609690 | HCMV Early Events | 5.743889e-01 | 0.241 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.772789e-01 | 0.239 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.772789e-01 | 0.239 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.810648e-01 | 0.236 |
| R-HSA-428157 | Sphingolipid metabolism | 5.869109e-01 | 0.231 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.882609e-01 | 0.230 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.885359e-01 | 0.230 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.885359e-01 | 0.230 |
| R-HSA-9679506 | SARS-CoV Infections | 5.891330e-01 | 0.230 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.918436e-01 | 0.228 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.918436e-01 | 0.228 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.958746e-01 | 0.225 |
| R-HSA-72172 | mRNA Splicing | 5.967327e-01 | 0.224 |
| R-HSA-391251 | Protein folding | 5.994951e-01 | 0.222 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.030833e-01 | 0.220 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.030833e-01 | 0.220 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.066397e-01 | 0.217 |
| R-HSA-1474290 | Collagen formation | 6.066397e-01 | 0.217 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.101644e-01 | 0.215 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.171199e-01 | 0.210 |
| R-HSA-190236 | Signaling by FGFR | 6.239522e-01 | 0.205 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.239522e-01 | 0.205 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.239522e-01 | 0.205 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.239522e-01 | 0.205 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.306634e-01 | 0.200 |
| R-HSA-70171 | Glycolysis | 6.306634e-01 | 0.200 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.339743e-01 | 0.198 |
| R-HSA-8951664 | Neddylation | 6.365316e-01 | 0.196 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.372557e-01 | 0.196 |
| R-HSA-111885 | Opioid Signalling | 6.437311e-01 | 0.191 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.469256e-01 | 0.189 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.469256e-01 | 0.189 |
| R-HSA-8953854 | Metabolism of RNA | 6.486697e-01 | 0.188 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.520099e-01 | 0.186 |
| R-HSA-69239 | Synthesis of DNA | 6.563395e-01 | 0.183 |
| R-HSA-211000 | Gene Silencing by RNA | 6.563395e-01 | 0.183 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.594217e-01 | 0.181 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.624765e-01 | 0.179 |
| R-HSA-73894 | DNA Repair | 6.631211e-01 | 0.178 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.683227e-01 | 0.175 |
| R-HSA-6803157 | Antimicrobial peptides | 6.685047e-01 | 0.175 |
| R-HSA-157118 | Signaling by NOTCH | 6.773276e-01 | 0.169 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.773470e-01 | 0.169 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.773470e-01 | 0.169 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.859551e-01 | 0.164 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.859551e-01 | 0.164 |
| R-HSA-373760 | L1CAM interactions | 6.887735e-01 | 0.162 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.913977e-01 | 0.160 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.915667e-01 | 0.160 |
| R-HSA-70326 | Glucose metabolism | 6.915667e-01 | 0.160 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.915667e-01 | 0.160 |
| R-HSA-5693538 | Homology Directed Repair | 6.943351e-01 | 0.158 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.970787e-01 | 0.157 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.970787e-01 | 0.157 |
| R-HSA-9609646 | HCMV Infection | 6.972727e-01 | 0.157 |
| R-HSA-73886 | Chromosome Maintenance | 7.024929e-01 | 0.153 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.031079e-01 | 0.153 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.051639e-01 | 0.152 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.051639e-01 | 0.152 |
| R-HSA-5688426 | Deubiquitination | 7.068601e-01 | 0.151 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.078110e-01 | 0.150 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.078110e-01 | 0.150 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.104346e-01 | 0.148 |
| R-HSA-977606 | Regulation of Complement cascade | 7.130347e-01 | 0.147 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.140735e-01 | 0.146 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.156117e-01 | 0.145 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.156117e-01 | 0.145 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.156117e-01 | 0.145 |
| R-HSA-69481 | G2/M Checkpoints | 7.206968e-01 | 0.142 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.281557e-01 | 0.138 |
| R-HSA-109582 | Hemostasis | 7.307315e-01 | 0.136 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.354168e-01 | 0.133 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.410217e-01 | 0.130 |
| R-HSA-1280218 | Adaptive Immune System | 7.445671e-01 | 0.128 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.470930e-01 | 0.127 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.470930e-01 | 0.127 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.516189e-01 | 0.124 |
| R-HSA-6807070 | PTEN Regulation | 7.538516e-01 | 0.123 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.538516e-01 | 0.123 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.543652e-01 | 0.122 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.582574e-01 | 0.120 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.625848e-01 | 0.118 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.625848e-01 | 0.118 |
| R-HSA-166658 | Complement cascade | 7.689322e-01 | 0.114 |
| R-HSA-195721 | Signaling by WNT | 7.792930e-01 | 0.108 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.830948e-01 | 0.106 |
| R-HSA-69306 | DNA Replication | 7.850464e-01 | 0.105 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.888974e-01 | 0.103 |
| R-HSA-1989781 | PPARA activates gene expression | 7.888974e-01 | 0.103 |
| R-HSA-9610379 | HCMV Late Events | 7.926799e-01 | 0.101 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.926799e-01 | 0.101 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.945458e-01 | 0.100 |
| R-HSA-9711097 | Cellular response to starvation | 7.945458e-01 | 0.100 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.982278e-01 | 0.098 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.127272e-01 | 0.090 |
| R-HSA-9824446 | Viral Infection Pathways | 8.127485e-01 | 0.090 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.138393e-01 | 0.089 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.138393e-01 | 0.089 |
| R-HSA-72306 | tRNA processing | 8.173378e-01 | 0.088 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.189832e-01 | 0.087 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.222301e-01 | 0.085 |
| R-HSA-611105 | Respiratory electron transport | 8.300964e-01 | 0.081 |
| R-HSA-597592 | Post-translational protein modification | 8.312608e-01 | 0.080 |
| R-HSA-168255 | Influenza Infection | 8.316276e-01 | 0.080 |
| R-HSA-69275 | G2/M Transition | 8.419696e-01 | 0.075 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.446005e-01 | 0.073 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.448068e-01 | 0.073 |
| R-HSA-5663205 | Infectious disease | 8.494846e-01 | 0.071 |
| R-HSA-6805567 | Keratinization | 8.693595e-01 | 0.061 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.762800e-01 | 0.057 |
| R-HSA-397014 | Muscle contraction | 8.762800e-01 | 0.057 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.939729e-01 | 0.049 |
| R-HSA-15869 | Metabolism of nucleotides | 9.005057e-01 | 0.046 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.014057e-01 | 0.045 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.170492e-01 | 0.038 |
| R-HSA-416476 | G alpha (q) signalling events | 9.228739e-01 | 0.035 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.279762e-01 | 0.032 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.618013e-01 | 0.017 |
| R-HSA-388396 | GPCR downstream signalling | 9.752850e-01 | 0.011 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.773435e-01 | 0.010 |
| R-HSA-392499 | Metabolism of proteins | 9.776106e-01 | 0.010 |
| R-HSA-418594 | G alpha (i) signalling events | 9.793315e-01 | 0.009 |
| R-HSA-5668914 | Diseases of metabolism | 9.828025e-01 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 9.864290e-01 | 0.006 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.867105e-01 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 9.946353e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.995332e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.795 | 0.112 | 2 | 0.771 |
CLK3 |
0.790 | 0.105 | 1 | 0.634 |
GRK1 |
0.789 | 0.157 | -2 | 0.835 |
CDC7 |
0.786 | 0.085 | 1 | 0.648 |
IKKB |
0.785 | 0.115 | -2 | 0.797 |
MTOR |
0.783 | 0.138 | 1 | 0.649 |
KIS |
0.783 | 0.059 | 1 | 0.554 |
MOS |
0.782 | 0.093 | 1 | 0.653 |
IKKE |
0.782 | 0.181 | 1 | 0.711 |
IKKA |
0.781 | 0.130 | -2 | 0.790 |
GRK7 |
0.780 | 0.166 | 1 | 0.589 |
TBK1 |
0.779 | 0.139 | 1 | 0.689 |
DSTYK |
0.777 | 0.057 | 2 | 0.799 |
GRK5 |
0.777 | 0.098 | -3 | 0.823 |
GRK6 |
0.777 | 0.134 | 1 | 0.658 |
BMPR1B |
0.775 | 0.123 | 1 | 0.631 |
GRK4 |
0.775 | 0.105 | -2 | 0.890 |
RAF1 |
0.774 | 0.084 | 1 | 0.729 |
CAMK2G |
0.773 | 0.068 | 2 | 0.716 |
NDR2 |
0.772 | 0.014 | -3 | 0.743 |
PIM3 |
0.771 | -0.003 | -3 | 0.737 |
CDK1 |
0.771 | 0.068 | 1 | 0.507 |
PDHK4 |
0.770 | 0.037 | 1 | 0.696 |
PRPK |
0.769 | -0.062 | -1 | 0.868 |
GCN2 |
0.769 | -0.086 | 2 | 0.716 |
ATR |
0.768 | 0.025 | 1 | 0.619 |
CK1G1 |
0.768 | 0.123 | -3 | 0.609 |
FAM20C |
0.766 | 0.020 | 2 | 0.488 |
MLK1 |
0.766 | -0.000 | 2 | 0.738 |
GSK3A |
0.766 | 0.193 | 4 | 0.579 |
NEK6 |
0.766 | -0.021 | -2 | 0.899 |
BMPR2 |
0.765 | -0.028 | -2 | 0.909 |
HIPK4 |
0.765 | 0.013 | 1 | 0.615 |
PDHK1 |
0.765 | 0.024 | 1 | 0.725 |
MST4 |
0.765 | 0.023 | 2 | 0.792 |
SRPK1 |
0.765 | -0.001 | -3 | 0.629 |
NLK |
0.764 | -0.018 | 1 | 0.664 |
RSK2 |
0.764 | 0.043 | -3 | 0.641 |
NEK7 |
0.764 | -0.034 | -3 | 0.763 |
CDK8 |
0.763 | 0.010 | 1 | 0.545 |
TGFBR2 |
0.763 | -0.006 | -2 | 0.835 |
TTBK2 |
0.763 | 0.040 | 2 | 0.679 |
CHAK2 |
0.762 | -0.002 | -1 | 0.866 |
CK2A2 |
0.762 | 0.082 | 1 | 0.533 |
BCKDK |
0.761 | 0.013 | -1 | 0.784 |
ERK5 |
0.761 | -0.040 | 1 | 0.631 |
CAMK1B |
0.761 | -0.032 | -3 | 0.742 |
ULK2 |
0.761 | -0.109 | 2 | 0.690 |
TLK2 |
0.761 | 0.100 | 1 | 0.648 |
SKMLCK |
0.760 | -0.011 | -2 | 0.890 |
MARK4 |
0.760 | -0.027 | 4 | 0.817 |
HUNK |
0.760 | -0.065 | 2 | 0.728 |
BMPR1A |
0.760 | 0.094 | 1 | 0.621 |
TGFBR1 |
0.759 | 0.053 | -2 | 0.845 |
CAMK2B |
0.759 | 0.058 | 2 | 0.687 |
DLK |
0.759 | 0.056 | 1 | 0.663 |
CAMK2A |
0.759 | 0.075 | 2 | 0.712 |
RIPK3 |
0.759 | -0.079 | 3 | 0.320 |
ACVR2B |
0.758 | 0.071 | -2 | 0.845 |
CDK19 |
0.758 | 0.004 | 1 | 0.520 |
MLK3 |
0.758 | 0.003 | 2 | 0.692 |
ALK4 |
0.757 | 0.046 | -2 | 0.872 |
NDR1 |
0.757 | -0.035 | -3 | 0.717 |
YSK4 |
0.757 | 0.110 | 1 | 0.681 |
CAMK2D |
0.757 | 0.022 | -3 | 0.695 |
CK1E |
0.757 | 0.071 | -3 | 0.597 |
ACVR2A |
0.757 | 0.054 | -2 | 0.826 |
GSK3B |
0.757 | 0.164 | 4 | 0.576 |
CLK2 |
0.757 | 0.047 | -3 | 0.630 |
GRK2 |
0.756 | 0.056 | -2 | 0.794 |
SRPK3 |
0.756 | -0.002 | -3 | 0.611 |
JNK3 |
0.756 | 0.038 | 1 | 0.528 |
PRKD1 |
0.756 | -0.001 | -3 | 0.680 |
CDK3 |
0.756 | 0.029 | 1 | 0.461 |
PLK3 |
0.756 | 0.070 | 2 | 0.668 |
DNAPK |
0.755 | 0.096 | 1 | 0.625 |
NIK |
0.755 | -0.057 | -3 | 0.773 |
NUAK2 |
0.755 | -0.058 | -3 | 0.713 |
JNK2 |
0.755 | 0.043 | 1 | 0.519 |
CDKL1 |
0.755 | -0.046 | -3 | 0.686 |
WNK1 |
0.755 | -0.032 | -2 | 0.881 |
SRPK2 |
0.754 | -0.009 | -3 | 0.547 |
ULK1 |
0.754 | -0.094 | -3 | 0.741 |
PIM1 |
0.754 | -0.015 | -3 | 0.664 |
ALK2 |
0.754 | 0.055 | -2 | 0.854 |
PLK1 |
0.754 | 0.020 | -2 | 0.853 |
ATM |
0.753 | -0.026 | 1 | 0.577 |
GRK3 |
0.753 | 0.071 | -2 | 0.759 |
ANKRD3 |
0.753 | -0.017 | 1 | 0.678 |
CK1D |
0.753 | 0.090 | -3 | 0.545 |
LATS2 |
0.753 | -0.010 | -5 | 0.754 |
LATS1 |
0.753 | 0.068 | -3 | 0.771 |
P90RSK |
0.753 | -0.010 | -3 | 0.646 |
CDK5 |
0.753 | 0.004 | 1 | 0.548 |
CK2A1 |
0.753 | 0.076 | 1 | 0.519 |
PKCD |
0.753 | -0.024 | 2 | 0.712 |
PKN2 |
0.753 | -0.026 | -3 | 0.703 |
MLK4 |
0.752 | -0.002 | 2 | 0.651 |
CK1A2 |
0.752 | 0.095 | -3 | 0.539 |
PKN3 |
0.752 | -0.065 | -3 | 0.703 |
PLK2 |
0.752 | 0.163 | -3 | 0.882 |
AMPKA1 |
0.752 | -0.052 | -3 | 0.723 |
DYRK2 |
0.752 | -0.003 | 1 | 0.570 |
CAMLCK |
0.752 | -0.048 | -2 | 0.875 |
HIPK2 |
0.751 | 0.024 | 1 | 0.499 |
PKACG |
0.751 | 0.004 | -2 | 0.767 |
ICK |
0.751 | -0.023 | -3 | 0.718 |
MASTL |
0.751 | -0.097 | -2 | 0.847 |
RSK3 |
0.751 | -0.010 | -3 | 0.637 |
ERK1 |
0.751 | 0.020 | 1 | 0.517 |
P38G |
0.750 | 0.026 | 1 | 0.455 |
AURC |
0.750 | 0.030 | -2 | 0.671 |
DAPK2 |
0.750 | -0.064 | -3 | 0.747 |
RSK4 |
0.749 | 0.028 | -3 | 0.626 |
P38B |
0.749 | 0.037 | 1 | 0.520 |
NEK9 |
0.749 | -0.080 | 2 | 0.766 |
CDKL5 |
0.749 | -0.051 | -3 | 0.668 |
QSK |
0.748 | -0.019 | 4 | 0.799 |
CDK13 |
0.748 | -0.018 | 1 | 0.521 |
PRKD2 |
0.748 | -0.016 | -3 | 0.617 |
CDK18 |
0.748 | 0.013 | 1 | 0.480 |
MEK1 |
0.748 | -0.004 | 2 | 0.756 |
MEKK3 |
0.748 | 0.049 | 1 | 0.667 |
CLK4 |
0.747 | 0.008 | -3 | 0.633 |
CDK2 |
0.747 | -0.008 | 1 | 0.566 |
TSSK1 |
0.747 | -0.030 | -3 | 0.748 |
PKR |
0.747 | -0.013 | 1 | 0.648 |
TLK1 |
0.747 | 0.039 | -2 | 0.891 |
MLK2 |
0.746 | -0.089 | 2 | 0.749 |
TSSK2 |
0.746 | -0.050 | -5 | 0.847 |
PASK |
0.746 | 0.118 | -3 | 0.760 |
AMPKA2 |
0.746 | -0.056 | -3 | 0.684 |
CLK1 |
0.745 | 0.009 | -3 | 0.595 |
P38A |
0.745 | 0.012 | 1 | 0.567 |
NIM1 |
0.745 | -0.081 | 3 | 0.350 |
WNK3 |
0.745 | -0.135 | 1 | 0.662 |
PAK6 |
0.745 | 0.096 | -2 | 0.714 |
SMG1 |
0.745 | 0.000 | 1 | 0.582 |
JNK1 |
0.745 | 0.039 | 1 | 0.494 |
MAPKAPK2 |
0.744 | -0.040 | -3 | 0.593 |
PKCA |
0.744 | -0.008 | 2 | 0.671 |
CDK17 |
0.744 | 0.006 | 1 | 0.448 |
MSK1 |
0.744 | 0.026 | -3 | 0.611 |
MARK3 |
0.743 | -0.018 | 4 | 0.767 |
PKCG |
0.743 | -0.024 | 2 | 0.683 |
CDK7 |
0.743 | -0.030 | 1 | 0.544 |
RIPK1 |
0.743 | -0.141 | 1 | 0.607 |
P70S6KB |
0.742 | -0.047 | -3 | 0.659 |
PKCB |
0.742 | -0.037 | 2 | 0.686 |
CDK12 |
0.742 | -0.015 | 1 | 0.506 |
PAK1 |
0.742 | -0.020 | -2 | 0.803 |
MEKK2 |
0.742 | 0.028 | 2 | 0.727 |
IRE1 |
0.742 | -0.127 | 1 | 0.586 |
PKACB |
0.742 | 0.018 | -2 | 0.695 |
AURA |
0.742 | 0.037 | -2 | 0.655 |
MST3 |
0.741 | 0.068 | 2 | 0.783 |
MSK2 |
0.741 | -0.031 | -3 | 0.610 |
PRP4 |
0.741 | 0.017 | -3 | 0.715 |
PRKX |
0.740 | 0.031 | -3 | 0.549 |
HIPK1 |
0.740 | -0.002 | 1 | 0.573 |
VRK2 |
0.740 | -0.130 | 1 | 0.667 |
MARK2 |
0.740 | -0.032 | 4 | 0.740 |
P38D |
0.739 | 0.025 | 1 | 0.464 |
SIK |
0.739 | -0.048 | -3 | 0.614 |
PLK4 |
0.739 | -0.041 | 2 | 0.534 |
GCK |
0.739 | 0.190 | 1 | 0.727 |
NEK2 |
0.739 | -0.038 | 2 | 0.747 |
TAO3 |
0.738 | 0.053 | 1 | 0.662 |
DYRK4 |
0.738 | 0.003 | 1 | 0.515 |
MAPKAPK3 |
0.738 | -0.087 | -3 | 0.621 |
ERK2 |
0.738 | -0.017 | 1 | 0.529 |
MEKK1 |
0.738 | -0.028 | 1 | 0.660 |
CHAK1 |
0.738 | -0.078 | 2 | 0.712 |
ZAK |
0.737 | -0.017 | 1 | 0.651 |
BRSK1 |
0.737 | -0.076 | -3 | 0.647 |
QIK |
0.737 | -0.097 | -3 | 0.690 |
CK1A |
0.737 | 0.095 | -3 | 0.475 |
PAK3 |
0.736 | -0.057 | -2 | 0.801 |
AURB |
0.736 | 0.002 | -2 | 0.675 |
TTBK1 |
0.736 | -0.020 | 2 | 0.587 |
BRAF |
0.735 | -0.031 | -4 | 0.709 |
MST2 |
0.735 | 0.106 | 1 | 0.714 |
MNK2 |
0.735 | -0.042 | -2 | 0.805 |
PKCH |
0.735 | -0.053 | 2 | 0.656 |
MEK5 |
0.735 | -0.074 | 2 | 0.738 |
NUAK1 |
0.734 | -0.089 | -3 | 0.651 |
CDK9 |
0.734 | -0.043 | 1 | 0.531 |
MARK1 |
0.734 | -0.049 | 4 | 0.773 |
IRE2 |
0.733 | -0.136 | 2 | 0.635 |
DRAK1 |
0.733 | -0.079 | 1 | 0.563 |
PHKG1 |
0.733 | -0.092 | -3 | 0.690 |
GAK |
0.733 | 0.065 | 1 | 0.623 |
CAMK4 |
0.733 | -0.112 | -3 | 0.683 |
PERK |
0.732 | -0.095 | -2 | 0.860 |
MNK1 |
0.732 | -0.048 | -2 | 0.817 |
MYLK4 |
0.732 | -0.051 | -2 | 0.803 |
PKCZ |
0.732 | -0.082 | 2 | 0.708 |
PKG2 |
0.731 | -0.014 | -2 | 0.689 |
CDK16 |
0.731 | 0.007 | 1 | 0.452 |
SGK3 |
0.731 | -0.022 | -3 | 0.614 |
PAK2 |
0.731 | -0.060 | -2 | 0.789 |
HPK1 |
0.730 | 0.163 | 1 | 0.735 |
AKT2 |
0.730 | -0.019 | -3 | 0.543 |
HIPK3 |
0.730 | -0.032 | 1 | 0.584 |
BRSK2 |
0.730 | -0.106 | -3 | 0.661 |
NEK5 |
0.729 | -0.064 | 1 | 0.635 |
EEF2K |
0.729 | -0.005 | 3 | 0.413 |
PRKD3 |
0.729 | -0.060 | -3 | 0.585 |
PINK1 |
0.728 | -0.110 | 1 | 0.604 |
CHK1 |
0.728 | -0.065 | -3 | 0.716 |
MINK |
0.728 | 0.119 | 1 | 0.720 |
TNIK |
0.728 | 0.080 | 3 | 0.401 |
TAK1 |
0.728 | 0.132 | 1 | 0.695 |
MPSK1 |
0.728 | -0.007 | 1 | 0.567 |
CDK14 |
0.728 | -0.016 | 1 | 0.520 |
CDK10 |
0.728 | -0.003 | 1 | 0.502 |
NEK11 |
0.728 | 0.017 | 1 | 0.665 |
DYRK1A |
0.727 | -0.038 | 1 | 0.582 |
KHS2 |
0.727 | 0.141 | 1 | 0.749 |
HRI |
0.726 | -0.128 | -2 | 0.877 |
DYRK1B |
0.726 | -0.030 | 1 | 0.524 |
KHS1 |
0.726 | 0.149 | 1 | 0.740 |
HGK |
0.726 | 0.056 | 3 | 0.403 |
PAK4 |
0.725 | 0.060 | -2 | 0.661 |
MST1 |
0.725 | 0.097 | 1 | 0.707 |
MELK |
0.725 | -0.137 | -3 | 0.651 |
WNK4 |
0.725 | -0.098 | -2 | 0.874 |
DCAMKL1 |
0.724 | -0.069 | -3 | 0.644 |
PIM2 |
0.724 | -0.059 | -3 | 0.600 |
NEK8 |
0.723 | -0.083 | 2 | 0.727 |
CAMK1G |
0.723 | -0.083 | -3 | 0.610 |
PKACA |
0.723 | 0.003 | -2 | 0.637 |
PAK5 |
0.722 | 0.030 | -2 | 0.655 |
CK1G3 |
0.722 | 0.123 | -3 | 0.432 |
MAPKAPK5 |
0.722 | -0.106 | -3 | 0.560 |
DYRK3 |
0.722 | -0.035 | 1 | 0.580 |
YANK3 |
0.720 | 0.037 | 2 | 0.370 |
SSTK |
0.720 | -0.080 | 4 | 0.787 |
TAO2 |
0.719 | -0.054 | 2 | 0.766 |
MAP3K15 |
0.719 | -0.020 | 1 | 0.642 |
SNRK |
0.718 | -0.191 | 2 | 0.571 |
PKCT |
0.718 | -0.079 | 2 | 0.665 |
PDK1 |
0.718 | -0.049 | 1 | 0.620 |
SMMLCK |
0.718 | -0.074 | -3 | 0.679 |
NEK4 |
0.717 | -0.024 | 1 | 0.675 |
ERK7 |
0.717 | -0.041 | 2 | 0.486 |
MAK |
0.716 | 0.012 | -2 | 0.724 |
AKT1 |
0.716 | -0.029 | -3 | 0.555 |
SLK |
0.716 | 0.021 | -2 | 0.730 |
DCAMKL2 |
0.716 | -0.072 | -3 | 0.663 |
CAMKK1 |
0.716 | -0.100 | -2 | 0.756 |
PKCE |
0.716 | -0.038 | 2 | 0.669 |
IRAK4 |
0.716 | -0.154 | 1 | 0.600 |
CDK6 |
0.716 | -0.034 | 1 | 0.504 |
LKB1 |
0.715 | -0.076 | -3 | 0.727 |
PHKG2 |
0.715 | -0.089 | -3 | 0.644 |
CAMKK2 |
0.715 | -0.080 | -2 | 0.747 |
PKCI |
0.714 | -0.073 | 2 | 0.676 |
DAPK3 |
0.714 | -0.045 | -3 | 0.667 |
MEKK6 |
0.714 | -0.059 | 1 | 0.664 |
DAPK1 |
0.713 | -0.027 | -3 | 0.649 |
P70S6K |
0.711 | -0.073 | -3 | 0.552 |
STK33 |
0.711 | -0.064 | 2 | 0.556 |
LOK |
0.711 | -0.016 | -2 | 0.778 |
PDHK3_TYR |
0.710 | 0.125 | 4 | 0.840 |
OSR1 |
0.710 | 0.002 | 2 | 0.727 |
LRRK2 |
0.710 | -0.078 | 2 | 0.755 |
TTK |
0.709 | 0.018 | -2 | 0.862 |
CDK4 |
0.709 | -0.044 | 1 | 0.496 |
YSK1 |
0.709 | -0.029 | 2 | 0.749 |
IRAK1 |
0.709 | -0.178 | -1 | 0.754 |
CK1G2 |
0.707 | 0.097 | -3 | 0.525 |
CAMK1D |
0.706 | -0.080 | -3 | 0.525 |
NEK1 |
0.706 | -0.090 | 1 | 0.630 |
VRK1 |
0.706 | -0.143 | 2 | 0.735 |
AKT3 |
0.706 | -0.022 | -3 | 0.480 |
SGK1 |
0.705 | -0.019 | -3 | 0.468 |
PDHK4_TYR |
0.705 | 0.087 | 2 | 0.758 |
BMPR2_TYR |
0.705 | 0.097 | -1 | 0.876 |
MRCKB |
0.705 | -0.020 | -3 | 0.584 |
MAP2K6_TYR |
0.704 | 0.066 | -1 | 0.886 |
MRCKA |
0.704 | -0.018 | -3 | 0.607 |
BUB1 |
0.704 | -0.020 | -5 | 0.822 |
ROCK2 |
0.704 | -0.022 | -3 | 0.648 |
MEK2 |
0.704 | -0.109 | 2 | 0.736 |
MAP2K4_TYR |
0.702 | 0.040 | -1 | 0.882 |
PDHK1_TYR |
0.702 | 0.074 | -1 | 0.892 |
MOK |
0.701 | -0.045 | 1 | 0.564 |
PKN1 |
0.701 | -0.083 | -3 | 0.557 |
RIPK2 |
0.700 | -0.170 | 1 | 0.620 |
HASPIN |
0.700 | -0.010 | -1 | 0.772 |
CHK2 |
0.700 | -0.058 | -3 | 0.473 |
MYO3A |
0.699 | 0.026 | 1 | 0.673 |
PBK |
0.698 | -0.072 | 1 | 0.576 |
ALPHAK3 |
0.697 | -0.008 | -1 | 0.777 |
MAP2K7_TYR |
0.696 | -0.089 | 2 | 0.754 |
YANK2 |
0.696 | 0.044 | 2 | 0.380 |
TESK1_TYR |
0.695 | -0.119 | 3 | 0.427 |
DMPK1 |
0.695 | -0.020 | -3 | 0.615 |
CAMK1A |
0.694 | -0.074 | -3 | 0.496 |
ASK1 |
0.694 | -0.061 | 1 | 0.625 |
PKMYT1_TYR |
0.693 | -0.116 | 3 | 0.399 |
MYO3B |
0.693 | -0.034 | 2 | 0.755 |
SBK |
0.692 | -0.049 | -3 | 0.415 |
NEK3 |
0.688 | -0.152 | 1 | 0.625 |
PKG1 |
0.688 | -0.043 | -2 | 0.600 |
TXK |
0.688 | -0.016 | 1 | 0.641 |
PINK1_TYR |
0.688 | -0.173 | 1 | 0.621 |
FGR |
0.688 | -0.034 | 1 | 0.636 |
EPHA6 |
0.687 | -0.059 | -1 | 0.836 |
TAO1 |
0.687 | -0.072 | 1 | 0.632 |
ROCK1 |
0.687 | -0.040 | -3 | 0.601 |
STLK3 |
0.686 | -0.052 | 1 | 0.637 |
CRIK |
0.685 | -0.036 | -3 | 0.559 |
RET |
0.684 | -0.111 | 1 | 0.650 |
YES1 |
0.684 | -0.057 | -1 | 0.833 |
EPHB4 |
0.684 | -0.089 | -1 | 0.802 |
BIKE |
0.684 | -0.068 | 1 | 0.521 |
FYN |
0.683 | 0.018 | -1 | 0.796 |
JAK2 |
0.683 | -0.111 | 1 | 0.663 |
CSF1R |
0.683 | -0.093 | 3 | 0.310 |
TYK2 |
0.683 | -0.137 | 1 | 0.659 |
LIMK2_TYR |
0.682 | -0.144 | -3 | 0.780 |
FER |
0.682 | -0.084 | 1 | 0.667 |
EPHA4 |
0.682 | -0.040 | 2 | 0.664 |
INSRR |
0.681 | -0.086 | 3 | 0.307 |
MST1R |
0.681 | -0.165 | 3 | 0.328 |
ROS1 |
0.680 | -0.150 | 3 | 0.294 |
BLK |
0.680 | -0.039 | -1 | 0.815 |
LCK |
0.680 | -0.055 | -1 | 0.811 |
ABL2 |
0.679 | -0.086 | -1 | 0.791 |
HCK |
0.679 | -0.096 | -1 | 0.805 |
SRMS |
0.679 | -0.084 | 1 | 0.663 |
KIT |
0.678 | -0.087 | 3 | 0.324 |
LIMK1_TYR |
0.677 | -0.217 | 2 | 0.753 |
JAK1 |
0.677 | -0.036 | 1 | 0.650 |
TYRO3 |
0.677 | -0.201 | 3 | 0.320 |
ABL1 |
0.677 | -0.078 | -1 | 0.784 |
FLT1 |
0.677 | -0.024 | -1 | 0.816 |
EPHB1 |
0.676 | -0.105 | 1 | 0.675 |
SYK |
0.676 | 0.049 | -1 | 0.763 |
JAK3 |
0.676 | -0.134 | 1 | 0.609 |
DDR1 |
0.675 | -0.156 | 4 | 0.780 |
EPHB2 |
0.675 | -0.082 | -1 | 0.778 |
FGFR2 |
0.675 | -0.111 | 3 | 0.363 |
KDR |
0.674 | -0.115 | 3 | 0.300 |
MET |
0.674 | -0.089 | 3 | 0.309 |
ITK |
0.674 | -0.109 | -1 | 0.770 |
TNK2 |
0.672 | -0.139 | 3 | 0.298 |
ERBB2 |
0.672 | -0.080 | 1 | 0.619 |
AAK1 |
0.672 | -0.036 | 1 | 0.443 |
PTK2 |
0.671 | 0.014 | -1 | 0.779 |
NEK10_TYR |
0.671 | -0.074 | 1 | 0.567 |
SRC |
0.671 | -0.042 | -1 | 0.790 |
BMX |
0.670 | -0.081 | -1 | 0.699 |
FLT3 |
0.670 | -0.152 | 3 | 0.319 |
LYN |
0.670 | -0.078 | 3 | 0.280 |
TEC |
0.670 | -0.093 | -1 | 0.699 |
PDGFRB |
0.670 | -0.179 | 3 | 0.325 |
EPHB3 |
0.669 | -0.144 | -1 | 0.775 |
TNNI3K_TYR |
0.669 | -0.109 | 1 | 0.649 |
FGFR3 |
0.669 | -0.091 | 3 | 0.342 |
FRK |
0.669 | -0.085 | -1 | 0.806 |
EGFR |
0.669 | -0.030 | 1 | 0.528 |
EPHA7 |
0.669 | -0.085 | 2 | 0.660 |
MERTK |
0.668 | -0.137 | 3 | 0.308 |
NTRK1 |
0.667 | -0.141 | -1 | 0.799 |
ALK |
0.667 | -0.138 | 3 | 0.274 |
PTK6 |
0.667 | -0.108 | -1 | 0.698 |
FGFR4 |
0.666 | -0.022 | -1 | 0.752 |
FGFR1 |
0.666 | -0.183 | 3 | 0.308 |
BTK |
0.666 | -0.149 | -1 | 0.731 |
EPHA3 |
0.665 | -0.105 | 2 | 0.639 |
TEK |
0.664 | -0.198 | 3 | 0.287 |
LTK |
0.664 | -0.139 | 3 | 0.293 |
WEE1_TYR |
0.664 | -0.111 | -1 | 0.742 |
TNK1 |
0.664 | -0.157 | 3 | 0.311 |
EPHA8 |
0.663 | -0.079 | -1 | 0.764 |
CSK |
0.663 | -0.069 | 2 | 0.672 |
NTRK3 |
0.663 | -0.118 | -1 | 0.750 |
EPHA5 |
0.663 | -0.084 | 2 | 0.636 |
INSR |
0.662 | -0.144 | 3 | 0.282 |
FLT4 |
0.662 | -0.141 | 3 | 0.318 |
NTRK2 |
0.661 | -0.172 | 3 | 0.306 |
MATK |
0.661 | -0.085 | -1 | 0.734 |
AXL |
0.661 | -0.189 | 3 | 0.306 |
PDGFRA |
0.660 | -0.210 | 3 | 0.318 |
ERBB4 |
0.660 | -0.040 | 1 | 0.545 |
PTK2B |
0.659 | -0.118 | -1 | 0.747 |
DDR2 |
0.659 | -0.107 | 3 | 0.306 |
EPHA1 |
0.657 | -0.169 | 3 | 0.282 |
EPHA2 |
0.656 | -0.075 | -1 | 0.734 |
IGF1R |
0.655 | -0.106 | 3 | 0.259 |
ZAP70 |
0.651 | -0.017 | -1 | 0.701 |
FES |
0.641 | -0.122 | -1 | 0.678 |
MUSK |
0.640 | -0.165 | 1 | 0.509 |