Motif 495 (n=192)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S512 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NKT7 | RGPD3 | S1583 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O14715 | RGPD8 | S1582 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14920 | IKBKB | S692 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15014 | ZNF609 | S433 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15355 | PPM1G | S215 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43182 | ARHGAP6 | S363 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43719 | HTATSF1 | S407 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60239 | SH3BP5 | S372 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
| O60271 | SPAG9 | S265 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60716 | CTNND1 | S879 | psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75037 | KIF21B | S1261 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75376 | NCOR1 | S2355 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75381 | PEX14 | S271 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O95049 | TJP3 | S339 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95359 | TACC2 | S2574 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P00533 | EGFR | S1039 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02545 | LMNA | S426 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02671 | FGA | S294 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04350 | TUBB4A | S95 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04350 | TUBB4A | S335 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | S95 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10636 | MAPT | S730 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S1799 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11274 | BCR | S235 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P11388 | TOP2A | S1374 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P13804 | ETFA | S182 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P14618 | PKM | S97 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P15924 | DSP | S2607 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16144 | ITGB4 | S1518 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P18583 | SON | S160 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19634 | SLC9A1 | S602 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P25054 | APC | S127 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27815 | PDE4A | S166 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P27816 | MAP4 | S896 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29590 | PML | S580 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P36956 | SREBF1 | S450 | ochoa | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. |
| P38398 | BRCA1 | S1483 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P43405 | SYK | S316 | ochoa | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P49023 | PXN | S106 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49792 | RANBP2 | S2558 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S999 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50548 | ERF | S187 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P50851 | LRBA | S1081 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51114 | FXR1 | S406 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P54646 | PRKAA2 | S501 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P54725 | RAD23A | S143 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P55265 | ADAR | S608 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P61978 | HNRNPK | S417 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P68371 | TUBB4B | S95 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78527 | PRKDC | S3018 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P82094 | TMF1 | S316 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P82094 | TMF1 | S333 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q02952 | AKAP12 | S648 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S803 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q04721 | NOTCH2 | S2090 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q07157 | TJP1 | S277 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S297 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S300 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S337 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12767 | TMEM94 | S454 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12789 | GTF3C1 | S1865 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12888 | TP53BP1 | S1037 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13136 | PPFIA1 | S239 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13263 | TRIM28 | S437 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13283 | G3BP1 | S250 | ochoa | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q13480 | GAB1 | S648 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13501 | SQSTM1 | S226 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13761 | RUNX3 | S223 | ochoa | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13796 | SHROOM2 | S177 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13835 | PKP1 | S188 | ochoa|psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q13885 | TUBB2A | S95 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14126 | DSG2 | S700 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14676 | MDC1 | S1214 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1419 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1460 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1501 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1583 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14699 | RFTN1 | S171 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14980 | NUMA1 | S1853 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15004 | PCLAF | S28 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15021 | NCAPD2 | S1330 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15398 | DLGAP5 | S627 | ochoa|psp | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15527 | SURF2 | S163 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q15555 | MAPRE2 | S229 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q16625 | OCLN | S341 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q16637 | SMN1 | S28 | ochoa|psp | Survival motor neuron protein (Component of gems 1) (Gemin-1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9845364). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (PubMed:17178713, PubMed:21816274, PubMed:22101937). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:17178713, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:22101937, ECO:0000269|PubMed:23063131, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9845364}. |
| Q16643 | DBN1 | S342 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q2KJY2 | KIF26B | S1141 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M2I8 | AAK1 | S690 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q32P44 | EML3 | S204 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q53GG5 | PDLIM3 | S148 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5JSZ5 | PRRC2B | S1486 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5M775 | SPECC1 | S151 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T200 | ZC3H13 | S338 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T8I3 | EEIG2 | S244 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5THJ4 | VPS13D | S2861 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5W0B1 | OBI1 | S571 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q63ZY3 | KANK2 | S175 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q6P2E9 | EDC4 | S705 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PJG2 | MIDEAS | S645 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6UUV7 | CRTC3 | S329 | ochoa|psp | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q71F23 | CENPU | S136 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z2W4 | ZC3HAV1 | S387 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3J3 | RGPD4 | S1583 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6L1 | TECPR1 | S409 | ochoa | Tectonin beta-propeller repeat-containing protein 1 | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
| Q7Z6Z7 | HUWE1 | S2907 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86SQ0 | PHLDB2 | S934 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86U44 | METTL3 | S64 | ochoa | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86V48 | LUZP1 | S531 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86YS7 | C2CD5 | S304 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q8IZ21 | PHACTR4 | S147 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N0Z3 | SPICE1 | S317 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N1G2 | CMTR1 | S46 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N3F8 | MICALL1 | S513 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S555 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S559 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3V7 | SYNPO | S718 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N488 | RYBP | S200 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8N6H7 | ARFGAP2 | S337 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N7R7 | CCNYL1 | S121 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8N8S7 | ENAH | S528 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8ND82 | ZNF280C | S114 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
| Q8TB45 | DEPTOR | S283 | ochoa|psp | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8WUY3 | PRUNE2 | S2345 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WUZ0 | BCL7C | S100 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
| Q8WWI1 | LMO7 | S991 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXG6 | MADD | S833 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q92625 | ANKS1A | S663 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92667 | AKAP1 | S583 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q969V6 | MRTFA | S133 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q969V6 | MRTFA | S136 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96AP7 | ESAM | S368 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
| Q96EC8 | YIPF6 | S24 | ochoa | Protein YIPF6 (YIP1 family member 6) | May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}. |
| Q96HC4 | PDLIM5 | S214 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JM3 | CHAMP1 | S328 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JQ0 | DCHS1 | S3055 | ochoa | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}. |
| Q96JY6 | PDLIM2 | S206 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96K76 | USP47 | S917 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96QD8 | SLC38A2 | S39 | ochoa | Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) | Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity). {ECO:0000250|UniProtKB:Q8CFE6, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15774260, ECO:0000269|PubMed:15922329, ECO:0000269|PubMed:16621798}. |
| Q96S38 | RPS6KC1 | S664 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96S90 | LYSMD1 | S23 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q96SU4 | OSBPL9 | S341 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q96T37 | RBM15 | S179 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99081 | TCF12 | S69 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99666 | RGPD5 | S1582 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQ89 | FAM110A | S249 | ochoa | Protein FAM110A | None |
| Q9BSQ5 | CCM2 | S248 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BSQ5 | CCM2 | S289 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BVA1 | TUBB2B | S95 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BX66 | SORBS1 | S481 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BZ29 | DOCK9 | S1255 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C0B5 | ZDHHC5 | S395 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0B5 | ZDHHC5 | S445 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S1158 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1178 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H089 | LSG1 | S625 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H0D6 | XRN2 | S448 | ochoa | 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) | Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}. |
| Q9H1K0 | RBSN | S235 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H3Q1 | CDC42EP4 | S312 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4A3 | WNK1 | S31 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H4L5 | OSBPL3 | S320 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H6W3 | RIOX1 | S63 | ochoa | Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}. |
| Q9HAW4 | CLSPN | S830 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HCK8 | CHD8 | S2220 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NQ84 | GPRC5C | S403 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9P0J7 | KCMF1 | S186 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P107 | GMIP | T457 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9UBC2 | EPS15L1 | S734 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UGU0 | TCF20 | S524 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UI08 | EVL | S338 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UIF9 | BAZ2A | S1747 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UJK0 | TSR3 | S264 | ochoa | 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}. |
| Q9UKI8 | TLK1 | S97 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKI8 | TLK1 | S100 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9ULT8 | HECTD1 | S1530 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UPN3 | MACF1 | S7342 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPN4 | CEP131 | S450 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPQ0 | LIMCH1 | S226 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ35 | SRRM2 | S2141 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQC2 | GAB2 | S445 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y2L9 | LRCH1 | S390 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81) | Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}. |
| Q9Y2W1 | THRAP3 | S237 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2W6 | TDRKH | S275 | ochoa | Tudor and KH domain-containing protein (Tudor domain-containing protein 2) | Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. {ECO:0000250|UniProtKB:Q80VL1}. |
| Q9Y4F5 | CEP170B | S951 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9C0C2 | TNKS1BP1 | S1051 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| O60566 | BUB1B | S694 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| P08684 | CYP3A4 | S116 | EPSD|PSP | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P51617 | IRAK1 | S568 | Sugiyama | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P51617 | IRAK1 | S588 | Sugiyama | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| Q9H4A4 | RNPEP | S27 | Sugiyama | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
| Q7RTN6 | STRADA | S49 | Sugiyama | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.303899e-09 | 8.638 |
| R-HSA-75153 | Apoptotic execution phase | 4.567277e-08 | 7.340 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.652234e-07 | 6.437 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 3.905912e-07 | 6.408 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 4.096885e-06 | 5.388 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.115284e-05 | 4.953 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.378540e-05 | 4.861 |
| R-HSA-68877 | Mitotic Prometaphase | 2.266449e-05 | 4.645 |
| R-HSA-9833482 | PKR-mediated signaling | 2.138920e-05 | 4.670 |
| R-HSA-983189 | Kinesins | 3.244370e-05 | 4.489 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.228238e-05 | 4.374 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 6.051501e-05 | 4.218 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.318646e-05 | 4.080 |
| R-HSA-437239 | Recycling pathway of L1 | 8.742738e-05 | 4.058 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 9.605244e-05 | 4.017 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.167908e-04 | 3.933 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.060640e-04 | 3.974 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.638310e-04 | 3.786 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.592165e-04 | 3.798 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.912282e-04 | 3.718 |
| R-HSA-190861 | Gap junction assembly | 2.060871e-04 | 3.686 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.309300e-04 | 3.637 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.687840e-04 | 3.571 |
| R-HSA-9663891 | Selective autophagy | 2.859381e-04 | 3.544 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.297779e-04 | 3.482 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.947626e-04 | 3.404 |
| R-HSA-9646399 | Aggrephagy | 3.835536e-04 | 3.416 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.246428e-04 | 3.372 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.628023e-04 | 3.335 |
| R-HSA-1640170 | Cell Cycle | 4.870905e-04 | 3.312 |
| R-HSA-9609690 | HCMV Early Events | 5.129347e-04 | 3.290 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.738510e-04 | 3.241 |
| R-HSA-190828 | Gap junction trafficking | 6.040306e-04 | 3.219 |
| R-HSA-109581 | Apoptosis | 5.861066e-04 | 3.232 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 6.507031e-04 | 3.187 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.020417e-04 | 3.154 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.160532e-04 | 3.145 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 7.753436e-04 | 3.111 |
| R-HSA-9609646 | HCMV Infection | 8.067843e-04 | 3.093 |
| R-HSA-68886 | M Phase | 7.737980e-04 | 3.111 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 9.226095e-04 | 3.035 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.007704e-03 | 2.997 |
| R-HSA-1632852 | Macroautophagy | 1.084920e-03 | 2.965 |
| R-HSA-68882 | Mitotic Anaphase | 1.035575e-03 | 2.985 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.068576e-03 | 2.971 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.404716e-03 | 2.852 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.408672e-03 | 2.851 |
| R-HSA-373760 | L1CAM interactions | 1.562959e-03 | 2.806 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.592303e-03 | 2.798 |
| R-HSA-9612973 | Autophagy | 1.976650e-03 | 2.704 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.220951e-03 | 2.653 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.243763e-03 | 2.649 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.599363e-03 | 2.585 |
| R-HSA-199991 | Membrane Trafficking | 2.582495e-03 | 2.588 |
| R-HSA-5357801 | Programmed Cell Death | 2.681982e-03 | 2.572 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.748203e-03 | 2.561 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.151720e-03 | 2.501 |
| R-HSA-180292 | GAB1 signalosome | 3.371046e-03 | 2.472 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.709786e-03 | 2.431 |
| R-HSA-69275 | G2/M Transition | 5.266287e-03 | 2.278 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.571410e-03 | 2.254 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.112658e-03 | 2.214 |
| R-HSA-5620924 | Intraflagellar transport | 6.112658e-03 | 2.214 |
| R-HSA-913531 | Interferon Signaling | 6.266884e-03 | 2.203 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 8.272366e-03 | 2.082 |
| R-HSA-177929 | Signaling by EGFR | 9.641907e-03 | 2.016 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.644509e-03 | 2.016 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 8.983418e-03 | 2.047 |
| R-HSA-391251 | Protein folding | 1.054200e-02 | 1.977 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.145666e-02 | 1.941 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.145666e-02 | 1.941 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.271156e-02 | 1.896 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.289517e-02 | 1.890 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.363939e-02 | 1.865 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.363939e-02 | 1.865 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.494824e-02 | 1.825 |
| R-HSA-162582 | Signal Transduction | 1.538974e-02 | 1.813 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.563136e-02 | 1.806 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.823098e-02 | 1.739 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.823098e-02 | 1.739 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.096349e-02 | 1.679 |
| R-HSA-5617833 | Cilium Assembly | 1.887740e-02 | 1.724 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 2.041089e-02 | 1.690 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.069742e-02 | 1.684 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.027583e-02 | 1.693 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.179674e-02 | 1.662 |
| R-HSA-380287 | Centrosome maturation | 2.266793e-02 | 1.645 |
| R-HSA-73887 | Death Receptor Signaling | 2.421317e-02 | 1.616 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.526231e-02 | 1.598 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.526231e-02 | 1.598 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 2.526231e-02 | 1.598 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.562998e-02 | 1.591 |
| R-HSA-165159 | MTOR signalling | 2.698294e-02 | 1.569 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.827711e-02 | 1.549 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.013129e-02 | 1.521 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 3.013129e-02 | 1.521 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.084753e-02 | 1.511 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.136470e-02 | 1.504 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.765428e-02 | 1.424 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 3.765428e-02 | 1.424 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.279729e-02 | 1.484 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.279729e-02 | 1.484 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.555212e-02 | 1.449 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.555212e-02 | 1.449 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.243624e-02 | 1.489 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.279729e-02 | 1.484 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.765428e-02 | 1.424 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.555212e-02 | 1.449 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.276913e-02 | 1.485 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.365231e-02 | 1.473 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 3.555212e-02 | 1.449 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.242491e-02 | 1.489 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.931301e-02 | 1.405 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.020201e-02 | 1.396 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 4.131767e-02 | 1.384 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.432323e-02 | 1.353 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.432323e-02 | 1.353 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 4.988946e-02 | 1.302 |
| R-HSA-8865999 | MET activates PTPN11 | 6.196983e-02 | 1.208 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 7.389734e-02 | 1.131 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 7.389734e-02 | 1.131 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 7.389734e-02 | 1.131 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 7.389734e-02 | 1.131 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 9.730145e-02 | 1.012 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 9.730145e-02 | 1.012 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 9.730145e-02 | 1.012 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 9.730145e-02 | 1.012 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 9.730145e-02 | 1.012 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.087818e-01 | 0.963 |
| R-HSA-9645135 | STAT5 Activation | 1.087818e-01 | 0.963 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.201169e-01 | 0.920 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 1.201169e-01 | 0.920 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.201169e-01 | 0.920 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.313085e-01 | 0.882 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.313085e-01 | 0.882 |
| R-HSA-8875656 | MET receptor recycling | 1.313085e-01 | 0.882 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.313085e-01 | 0.882 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.532685e-01 | 0.815 |
| R-HSA-350054 | Notch-HLH transcription pathway | 5.056734e-02 | 1.296 |
| R-HSA-4839744 | Signaling by APC mutants | 1.640404e-01 | 0.785 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.640404e-01 | 0.785 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.640404e-01 | 0.785 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.640404e-01 | 0.785 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.746759e-01 | 0.758 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.746759e-01 | 0.758 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.851768e-01 | 0.732 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.851768e-01 | 0.732 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.851768e-01 | 0.732 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.851768e-01 | 0.732 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.851768e-01 | 0.732 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.851768e-01 | 0.732 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.851768e-01 | 0.732 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 7.462013e-02 | 1.127 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.057813e-01 | 0.687 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.158883e-01 | 0.666 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.158883e-01 | 0.666 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.158883e-01 | 0.666 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.258673e-01 | 0.646 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.357199e-01 | 0.628 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.454477e-01 | 0.610 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.645352e-01 | 0.578 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.645352e-01 | 0.578 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.645352e-01 | 0.578 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.738979e-01 | 0.562 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.738979e-01 | 0.562 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.738979e-01 | 0.562 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.738979e-01 | 0.562 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.738979e-01 | 0.562 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.738979e-01 | 0.562 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.205488e-01 | 0.919 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.205488e-01 | 0.919 |
| R-HSA-191859 | snRNP Assembly | 2.117570e-01 | 0.674 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.117570e-01 | 0.674 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.304730e-01 | 0.637 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 6.392040e-02 | 1.194 |
| R-HSA-182971 | EGFR downregulation | 8.204712e-02 | 1.086 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.708611e-01 | 0.767 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.532685e-01 | 0.815 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.640404e-01 | 0.785 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 7.462013e-02 | 1.127 |
| R-HSA-191650 | Regulation of gap junction activity | 7.389734e-02 | 1.131 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.423584e-01 | 0.847 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.585134e-01 | 0.800 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.560950e-02 | 1.255 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.851768e-01 | 0.732 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.179240e-01 | 0.928 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.087818e-01 | 0.963 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.851768e-01 | 0.732 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.357199e-01 | 0.628 |
| R-HSA-1221632 | Meiotic synapsis | 1.840132e-01 | 0.735 |
| R-HSA-354192 | Integrin signaling | 8.969018e-02 | 1.047 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.969777e-02 | 1.099 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.011902e-02 | 1.154 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.201169e-01 | 0.920 |
| R-HSA-9613354 | Lipophagy | 1.423584e-01 | 0.847 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.357199e-01 | 0.628 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.568786e-01 | 0.804 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.256657e-02 | 1.139 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 7.830562e-02 | 1.106 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.851768e-01 | 0.732 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.263562e-01 | 0.898 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.480150e-01 | 0.830 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.258673e-01 | 0.646 |
| R-HSA-5693538 | Homology Directed Repair | 9.069380e-02 | 1.042 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.739906e-01 | 0.759 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 7.462013e-02 | 1.127 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 8.969018e-02 | 1.047 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 4.988946e-02 | 1.302 |
| R-HSA-75102 | C6 deamination of adenosine | 4.988946e-02 | 1.302 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 4.988946e-02 | 1.302 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 7.389734e-02 | 1.131 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.730145e-02 | 1.012 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.532685e-01 | 0.815 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.532685e-01 | 0.815 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.746759e-01 | 0.758 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.746759e-01 | 0.758 |
| R-HSA-525793 | Myogenesis | 6.392040e-02 | 1.194 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.955447e-01 | 0.709 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.158883e-01 | 0.666 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 2.258673e-01 | 0.646 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.357199e-01 | 0.628 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.550523e-01 | 0.593 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.164231e-01 | 0.665 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.494435e-01 | 0.826 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.428229e-01 | 0.615 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.428229e-01 | 0.615 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.530225e-01 | 0.597 |
| R-HSA-5260271 | Diseases of Immune System | 1.221220e-01 | 0.913 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.221220e-01 | 0.913 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.645352e-01 | 0.578 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.530225e-01 | 0.597 |
| R-HSA-9707616 | Heme signaling | 2.257821e-01 | 0.646 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.170537e-02 | 1.286 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 6.392040e-02 | 1.194 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.259860e-01 | 0.646 |
| R-HSA-75072 | mRNA Editing | 1.423584e-01 | 0.847 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.746759e-01 | 0.758 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.158883e-01 | 0.666 |
| R-HSA-9754706 | Atorvastatin ADME | 2.258673e-01 | 0.646 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.645352e-01 | 0.578 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.645352e-01 | 0.578 |
| R-HSA-6809371 | Formation of the cornified envelope | 2.598569e-01 | 0.585 |
| R-HSA-9664873 | Pexophagy | 1.532685e-01 | 0.815 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.560950e-02 | 1.255 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.057813e-01 | 0.687 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.357199e-01 | 0.628 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.003822e-01 | 0.998 |
| R-HSA-1226099 | Signaling by FGFR in disease | 8.906214e-02 | 1.050 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.159980e-01 | 0.666 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.824660e-01 | 0.549 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 7.389734e-02 | 1.131 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.201169e-01 | 0.920 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.201169e-01 | 0.920 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.313085e-01 | 0.882 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.057813e-01 | 0.687 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.158883e-01 | 0.666 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 8.906214e-02 | 1.050 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.794416e-01 | 0.746 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.840132e-01 | 0.735 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.995750e-01 | 0.700 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.728738e-01 | 0.564 |
| R-HSA-73894 | DNA Repair | 2.158693e-01 | 0.666 |
| R-HSA-157118 | Signaling by NOTCH | 5.124215e-02 | 1.290 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.391840e-02 | 1.268 |
| R-HSA-8848021 | Signaling by PTK6 | 2.304730e-01 | 0.637 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.304730e-01 | 0.637 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.874791e-01 | 0.727 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.096428e-01 | 0.960 |
| R-HSA-9607240 | FLT3 Signaling | 1.263562e-01 | 0.898 |
| R-HSA-69481 | G2/M Checkpoints | 1.105291e-01 | 0.957 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 9.730145e-02 | 1.012 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 9.730145e-02 | 1.012 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 9.730145e-02 | 1.012 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.640404e-01 | 0.785 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.851768e-01 | 0.732 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.851768e-01 | 0.732 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.851768e-01 | 0.732 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.057813e-01 | 0.687 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.057813e-01 | 0.687 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.158883e-01 | 0.666 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.158883e-01 | 0.666 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.168294e-01 | 0.932 |
| R-HSA-9945266 | Differentiation of T cells | 2.258673e-01 | 0.646 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 2.258673e-01 | 0.646 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.550523e-01 | 0.593 |
| R-HSA-68875 | Mitotic Prophase | 9.451298e-02 | 1.025 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.801403e-02 | 1.167 |
| R-HSA-1989781 | PPARA activates gene expression | 1.823911e-01 | 0.739 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 9.730145e-02 | 1.012 |
| R-HSA-5689877 | Josephin domain DUBs | 1.532685e-01 | 0.815 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.057813e-01 | 0.687 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.158883e-01 | 0.666 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.258673e-01 | 0.646 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.357199e-01 | 0.628 |
| R-HSA-8853659 | RET signaling | 1.055631e-01 | 0.976 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.454477e-01 | 0.610 |
| R-HSA-109704 | PI3K Cascade | 1.703537e-01 | 0.769 |
| R-HSA-9909396 | Circadian clock | 1.232832e-01 | 0.909 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.349267e-01 | 0.870 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 4.740727e-02 | 1.324 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 2.357199e-01 | 0.628 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.738979e-01 | 0.562 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.823044e-01 | 0.549 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.007108e-01 | 0.997 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.834747e-01 | 0.736 |
| R-HSA-70171 | Glycolysis | 1.708611e-01 | 0.767 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.505409e-01 | 0.822 |
| R-HSA-450294 | MAP kinase activation | 2.210984e-01 | 0.655 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.723583e-01 | 0.764 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.221220e-01 | 0.913 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.851768e-01 | 0.732 |
| R-HSA-448424 | Interleukin-17 signaling | 2.634389e-01 | 0.579 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.851768e-01 | 0.732 |
| R-HSA-112399 | IRS-mediated signalling | 2.024567e-01 | 0.694 |
| R-HSA-109582 | Hemostasis | 2.330669e-01 | 0.633 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.794015e-02 | 1.319 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.640404e-01 | 0.785 |
| R-HSA-74160 | Gene expression (Transcription) | 1.433829e-01 | 0.844 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.423584e-01 | 0.847 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.158883e-01 | 0.666 |
| R-HSA-9629569 | Protein hydroxylation | 2.738979e-01 | 0.562 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 9.657193e-02 | 1.015 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.069380e-02 | 1.042 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.164231e-01 | 0.665 |
| R-HSA-212436 | Generic Transcription Pathway | 1.062209e-01 | 0.974 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 7.830562e-02 | 1.106 |
| R-HSA-445144 | Signal transduction by L1 | 2.738979e-01 | 0.562 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.075123e-01 | 0.683 |
| R-HSA-597592 | Post-translational protein modification | 2.414318e-01 | 0.617 |
| R-HSA-75893 | TNF signaling | 4.980526e-02 | 1.303 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.210984e-01 | 0.655 |
| R-HSA-112316 | Neuronal System | 9.935095e-02 | 1.003 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.376265e-01 | 0.861 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.634389e-01 | 0.579 |
| R-HSA-202403 | TCR signaling | 2.061083e-01 | 0.686 |
| R-HSA-70326 | Glucose metabolism | 2.360619e-01 | 0.627 |
| R-HSA-1538133 | G0 and Early G1 | 8.584263e-02 | 1.066 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.634389e-01 | 0.579 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.610636e-02 | 1.180 |
| R-HSA-1266738 | Developmental Biology | 1.299190e-01 | 0.886 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.616779e-02 | 1.179 |
| R-HSA-5688426 | Deubiquitination | 2.771594e-01 | 0.557 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.537381e-02 | 1.257 |
| R-HSA-202433 | Generation of second messenger molecules | 1.221220e-01 | 0.913 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.306250e-01 | 0.884 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.351704e-01 | 0.629 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.642953e-02 | 1.016 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 9.753379e-02 | 1.011 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.360619e-01 | 0.627 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.802546e-01 | 0.744 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.645352e-01 | 0.578 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.398732e-01 | 0.620 |
| R-HSA-9824446 | Viral Infection Pathways | 1.508857e-01 | 0.821 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.961451e-01 | 0.707 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.436232e-01 | 0.843 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.180044e-01 | 0.662 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.351704e-01 | 0.629 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.376265e-01 | 0.861 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.496154e-01 | 0.603 |
| R-HSA-422475 | Axon guidance | 1.126022e-01 | 0.948 |
| R-HSA-2028269 | Signaling by Hippo | 2.454477e-01 | 0.610 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.963275e-01 | 0.707 |
| R-HSA-9675108 | Nervous system development | 1.527365e-01 | 0.816 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.963275e-01 | 0.707 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.389136e-01 | 0.857 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.351704e-01 | 0.629 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.831421e-01 | 0.548 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.831421e-01 | 0.548 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.831421e-01 | 0.548 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.831421e-01 | 0.548 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.831421e-01 | 0.548 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.831421e-01 | 0.548 |
| R-HSA-8852135 | Protein ubiquitination | 2.870162e-01 | 0.542 |
| R-HSA-9843745 | Adipogenesis | 2.908732e-01 | 0.536 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.922691e-01 | 0.534 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.922691e-01 | 0.534 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.922691e-01 | 0.534 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.922691e-01 | 0.534 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.922691e-01 | 0.534 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.922691e-01 | 0.534 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.012805e-01 | 0.521 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.012805e-01 | 0.521 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.012805e-01 | 0.521 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.012805e-01 | 0.521 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.012805e-01 | 0.521 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.058246e-01 | 0.515 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.091906e-01 | 0.510 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.101777e-01 | 0.508 |
| R-HSA-200425 | Carnitine shuttle | 3.101777e-01 | 0.508 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.101777e-01 | 0.508 |
| R-HSA-9018682 | Biosynthesis of maresins | 3.101777e-01 | 0.508 |
| R-HSA-3000170 | Syndecan interactions | 3.101777e-01 | 0.508 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.101777e-01 | 0.508 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.151964e-01 | 0.501 |
| R-HSA-9679506 | SARS-CoV Infections | 3.184755e-01 | 0.497 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.188472e-01 | 0.496 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.189621e-01 | 0.496 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.189621e-01 | 0.496 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.189621e-01 | 0.496 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.189621e-01 | 0.496 |
| R-HSA-429947 | Deadenylation of mRNA | 3.189621e-01 | 0.496 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.189621e-01 | 0.496 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.189621e-01 | 0.496 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 3.276352e-01 | 0.485 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.276352e-01 | 0.485 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.276352e-01 | 0.485 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.276352e-01 | 0.485 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.276352e-01 | 0.485 |
| R-HSA-9839394 | TGFBR3 expression | 3.276352e-01 | 0.485 |
| R-HSA-2160916 | Hyaluronan degradation | 3.276352e-01 | 0.485 |
| R-HSA-3000157 | Laminin interactions | 3.276352e-01 | 0.485 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.278667e-01 | 0.484 |
| R-HSA-1500620 | Meiosis | 3.338510e-01 | 0.476 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.338510e-01 | 0.476 |
| R-HSA-446728 | Cell junction organization | 3.341814e-01 | 0.476 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.361984e-01 | 0.473 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.361984e-01 | 0.473 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.361984e-01 | 0.473 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.366921e-01 | 0.473 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.395342e-01 | 0.469 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.431251e-01 | 0.465 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.431251e-01 | 0.465 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.446531e-01 | 0.463 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.446531e-01 | 0.463 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 3.446531e-01 | 0.463 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.446531e-01 | 0.463 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.446531e-01 | 0.463 |
| R-HSA-70268 | Pyruvate metabolism | 3.477470e-01 | 0.459 |
| R-HSA-2262752 | Cellular responses to stress | 3.523949e-01 | 0.453 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.530006e-01 | 0.452 |
| R-HSA-9757110 | Prednisone ADME | 3.530006e-01 | 0.452 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.569025e-01 | 0.447 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.569580e-01 | 0.447 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.612422e-01 | 0.442 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.612422e-01 | 0.442 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.612422e-01 | 0.442 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.612422e-01 | 0.442 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.612422e-01 | 0.442 |
| R-HSA-180024 | DARPP-32 events | 3.612422e-01 | 0.442 |
| R-HSA-112310 | Neurotransmitter release cycle | 3.615463e-01 | 0.442 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.693794e-01 | 0.433 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.693794e-01 | 0.433 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.693794e-01 | 0.433 |
| R-HSA-2424491 | DAP12 signaling | 3.693794e-01 | 0.433 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.693794e-01 | 0.433 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.693794e-01 | 0.433 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.706860e-01 | 0.431 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.707557e-01 | 0.431 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.752366e-01 | 0.426 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.774134e-01 | 0.423 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.774134e-01 | 0.423 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.774134e-01 | 0.423 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.853456e-01 | 0.414 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.853456e-01 | 0.414 |
| R-HSA-1280218 | Adaptive Immune System | 3.911647e-01 | 0.408 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.931772e-01 | 0.405 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.931772e-01 | 0.405 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.931772e-01 | 0.405 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.931772e-01 | 0.405 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.931772e-01 | 0.405 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.931772e-01 | 0.405 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.931772e-01 | 0.405 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.931772e-01 | 0.405 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.931772e-01 | 0.405 |
| R-HSA-9930044 | Nuclear RNA decay | 3.931772e-01 | 0.405 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.931772e-01 | 0.405 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.977811e-01 | 0.400 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.977811e-01 | 0.400 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.982855e-01 | 0.400 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.009094e-01 | 0.397 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.009094e-01 | 0.397 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.009094e-01 | 0.397 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.009094e-01 | 0.397 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.009094e-01 | 0.397 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.066947e-01 | 0.391 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.066947e-01 | 0.391 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.066947e-01 | 0.391 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.085436e-01 | 0.389 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.085436e-01 | 0.389 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.085436e-01 | 0.389 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.085436e-01 | 0.389 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.085436e-01 | 0.389 |
| R-HSA-2142845 | Hyaluronan metabolism | 4.085436e-01 | 0.389 |
| R-HSA-5205647 | Mitophagy | 4.085436e-01 | 0.389 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 4.085436e-01 | 0.389 |
| R-HSA-9614085 | FOXO-mediated transcription | 4.111279e-01 | 0.386 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 4.111279e-01 | 0.386 |
| R-HSA-6798695 | Neutrophil degranulation | 4.124117e-01 | 0.385 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.138980e-01 | 0.383 |
| R-HSA-8953854 | Metabolism of RNA | 4.146316e-01 | 0.382 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.160811e-01 | 0.381 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 4.160811e-01 | 0.381 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.160811e-01 | 0.381 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.160811e-01 | 0.381 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.160811e-01 | 0.381 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.160811e-01 | 0.381 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.229526e-01 | 0.374 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.235229e-01 | 0.373 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.235229e-01 | 0.373 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.235229e-01 | 0.373 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.235229e-01 | 0.373 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.235229e-01 | 0.373 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.243288e-01 | 0.372 |
| R-HSA-1500931 | Cell-Cell communication | 4.298434e-01 | 0.367 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.308703e-01 | 0.366 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.308703e-01 | 0.366 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.308703e-01 | 0.366 |
| R-HSA-8875878 | MET promotes cell motility | 4.381245e-01 | 0.358 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.381245e-01 | 0.358 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.381245e-01 | 0.358 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.416895e-01 | 0.355 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.452867e-01 | 0.351 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.452867e-01 | 0.351 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.452867e-01 | 0.351 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.456073e-01 | 0.351 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.456073e-01 | 0.351 |
| R-HSA-8957322 | Metabolism of steroids | 4.497716e-01 | 0.347 |
| R-HSA-211000 | Gene Silencing by RNA | 4.502620e-01 | 0.347 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.523580e-01 | 0.345 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.523580e-01 | 0.345 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.523580e-01 | 0.345 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.523580e-01 | 0.345 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.523580e-01 | 0.345 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.523580e-01 | 0.345 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.545205e-01 | 0.342 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.545205e-01 | 0.342 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.587601e-01 | 0.338 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.593397e-01 | 0.338 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 4.593397e-01 | 0.338 |
| R-HSA-9694548 | Maturation of spike protein | 4.593397e-01 | 0.338 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.593397e-01 | 0.338 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.593397e-01 | 0.338 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.629807e-01 | 0.334 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.629807e-01 | 0.334 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 4.629807e-01 | 0.334 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.662327e-01 | 0.331 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.662327e-01 | 0.331 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.755263e-01 | 0.323 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.785039e-01 | 0.320 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.797576e-01 | 0.319 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.797576e-01 | 0.319 |
| R-HSA-8854214 | TBC/RABGAPs | 4.797576e-01 | 0.319 |
| R-HSA-2172127 | DAP12 interactions | 4.863915e-01 | 0.313 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.878939e-01 | 0.312 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.919760e-01 | 0.308 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.919760e-01 | 0.308 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.929413e-01 | 0.307 |
| R-HSA-774815 | Nucleosome assembly | 4.929413e-01 | 0.307 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.929413e-01 | 0.307 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.929413e-01 | 0.307 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.929413e-01 | 0.307 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.994080e-01 | 0.302 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.994080e-01 | 0.302 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.994080e-01 | 0.302 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.994080e-01 | 0.302 |
| R-HSA-9675135 | Diseases of DNA repair | 4.994080e-01 | 0.302 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.994080e-01 | 0.302 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.994080e-01 | 0.302 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.994080e-01 | 0.302 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.000788e-01 | 0.301 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.010591e-01 | 0.300 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.057926e-01 | 0.296 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.120961e-01 | 0.291 |
| R-HSA-425410 | Metal ion SLC transporters | 5.120961e-01 | 0.291 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.136138e-01 | 0.289 |
| R-HSA-9766229 | Degradation of CDH1 | 5.183196e-01 | 0.285 |
| R-HSA-73893 | DNA Damage Bypass | 5.183196e-01 | 0.285 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.183196e-01 | 0.285 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.198638e-01 | 0.284 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.238864e-01 | 0.281 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 5.244641e-01 | 0.280 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.305307e-01 | 0.275 |
| R-HSA-912446 | Meiotic recombination | 5.305307e-01 | 0.275 |
| R-HSA-194138 | Signaling by VEGF | 5.355029e-01 | 0.271 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.365202e-01 | 0.270 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.365202e-01 | 0.270 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.365202e-01 | 0.270 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.410442e-01 | 0.267 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.413930e-01 | 0.266 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.424336e-01 | 0.266 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.424336e-01 | 0.266 |
| R-HSA-72172 | mRNA Splicing | 5.474424e-01 | 0.262 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.482720e-01 | 0.261 |
| R-HSA-6805567 | Keratinization | 5.534453e-01 | 0.257 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.540362e-01 | 0.256 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.540362e-01 | 0.256 |
| R-HSA-1474165 | Reproduction | 5.581497e-01 | 0.253 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.597272e-01 | 0.252 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.597272e-01 | 0.252 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.597272e-01 | 0.252 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.653459e-01 | 0.248 |
| R-HSA-5621480 | Dectin-2 family | 5.653459e-01 | 0.248 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.653459e-01 | 0.248 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.654368e-01 | 0.248 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.708933e-01 | 0.243 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.708933e-01 | 0.243 |
| R-HSA-9033241 | Peroxisomal protein import | 5.763702e-01 | 0.239 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.763702e-01 | 0.239 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.763702e-01 | 0.239 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.817776e-01 | 0.235 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.817776e-01 | 0.235 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.817776e-01 | 0.235 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.817776e-01 | 0.235 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.817776e-01 | 0.235 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.817776e-01 | 0.235 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.871163e-01 | 0.231 |
| R-HSA-418990 | Adherens junctions interactions | 5.884557e-01 | 0.230 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.923871e-01 | 0.227 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.923871e-01 | 0.227 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.923871e-01 | 0.227 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.941309e-01 | 0.226 |
| R-HSA-8951664 | Neddylation | 5.969309e-01 | 0.224 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.975910e-01 | 0.224 |
| R-HSA-211981 | Xenobiotics | 6.027287e-01 | 0.220 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.177536e-01 | 0.209 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.177536e-01 | 0.209 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.213156e-01 | 0.207 |
| R-HSA-166520 | Signaling by NTRKs | 6.278897e-01 | 0.202 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.322129e-01 | 0.199 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.322129e-01 | 0.199 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.322129e-01 | 0.199 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.343753e-01 | 0.198 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.369106e-01 | 0.196 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.369106e-01 | 0.196 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.369106e-01 | 0.196 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 6.369106e-01 | 0.196 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.410513e-01 | 0.193 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.415487e-01 | 0.193 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.415487e-01 | 0.193 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.415487e-01 | 0.193 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.415487e-01 | 0.193 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.461278e-01 | 0.190 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.461278e-01 | 0.190 |
| R-HSA-9749641 | Aspirin ADME | 6.461278e-01 | 0.190 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.506486e-01 | 0.187 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.551120e-01 | 0.184 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.551120e-01 | 0.184 |
| R-HSA-9610379 | HCMV Late Events | 6.563820e-01 | 0.183 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.594385e-01 | 0.181 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.595186e-01 | 0.181 |
| R-HSA-877300 | Interferon gamma signaling | 6.624732e-01 | 0.179 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.638692e-01 | 0.178 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.654862e-01 | 0.177 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.681645e-01 | 0.175 |
| R-HSA-216083 | Integrin cell surface interactions | 6.681645e-01 | 0.175 |
| R-HSA-191273 | Cholesterol biosynthesis | 6.681645e-01 | 0.175 |
| R-HSA-421270 | Cell-cell junction organization | 6.753047e-01 | 0.171 |
| R-HSA-6806834 | Signaling by MET | 6.765919e-01 | 0.170 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.765919e-01 | 0.170 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.765919e-01 | 0.170 |
| R-HSA-977225 | Amyloid fiber formation | 6.807254e-01 | 0.167 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 6.807254e-01 | 0.167 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.848062e-01 | 0.164 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.888352e-01 | 0.162 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.928129e-01 | 0.159 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.928129e-01 | 0.159 |
| R-HSA-5663205 | Infectious disease | 6.989198e-01 | 0.156 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.999770e-01 | 0.155 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.006172e-01 | 0.155 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.006172e-01 | 0.155 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.033539e-01 | 0.153 |
| R-HSA-1643685 | Disease | 7.037523e-01 | 0.153 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 7.044451e-01 | 0.152 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.054313e-01 | 0.152 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.119552e-01 | 0.148 |
| R-HSA-202424 | Downstream TCR signaling | 7.192754e-01 | 0.143 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.239315e-01 | 0.140 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.299100e-01 | 0.137 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.333650e-01 | 0.135 |
| R-HSA-2029481 | FCGR activation | 7.333650e-01 | 0.135 |
| R-HSA-1474290 | Collagen formation | 7.367761e-01 | 0.133 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.401437e-01 | 0.131 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.437590e-01 | 0.129 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.499914e-01 | 0.125 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.499914e-01 | 0.125 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.531907e-01 | 0.123 |
| R-HSA-190236 | Signaling by FGFR | 7.531907e-01 | 0.123 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.625462e-01 | 0.118 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.655857e-01 | 0.116 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.715488e-01 | 0.113 |
| R-HSA-111885 | Opioid Signalling | 7.715488e-01 | 0.113 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.744735e-01 | 0.111 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.744735e-01 | 0.111 |
| R-HSA-195721 | Signaling by WNT | 7.746152e-01 | 0.111 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.773610e-01 | 0.109 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.777553e-01 | 0.109 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.858045e-01 | 0.105 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.965688e-01 | 0.099 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.965688e-01 | 0.099 |
| R-HSA-397014 | Muscle contraction | 7.981784e-01 | 0.098 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.017473e-01 | 0.096 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.042872e-01 | 0.095 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.092701e-01 | 0.092 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.092701e-01 | 0.092 |
| R-HSA-73886 | Chromosome Maintenance | 8.234740e-01 | 0.084 |
| R-HSA-3371556 | Cellular response to heat stress | 8.234740e-01 | 0.084 |
| R-HSA-168249 | Innate Immune System | 8.278113e-01 | 0.082 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.301761e-01 | 0.081 |
| R-HSA-168256 | Immune System | 8.318067e-01 | 0.080 |
| R-HSA-72312 | rRNA processing | 8.341140e-01 | 0.079 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.345029e-01 | 0.079 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.345029e-01 | 0.079 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.345029e-01 | 0.079 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.366249e-01 | 0.077 |
| R-HSA-114608 | Platelet degranulation | 8.387199e-01 | 0.076 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.407882e-01 | 0.075 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.423915e-01 | 0.074 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.526549e-01 | 0.069 |
| R-HSA-4839726 | Chromatin organization | 8.600237e-01 | 0.065 |
| R-HSA-163685 | Integration of energy metabolism | 8.600728e-01 | 0.065 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.605174e-01 | 0.065 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.618684e-01 | 0.065 |
| R-HSA-392499 | Metabolism of proteins | 8.627224e-01 | 0.064 |
| R-HSA-6807070 | PTEN Regulation | 8.653912e-01 | 0.063 |
| R-HSA-9664407 | Parasite infection | 8.671189e-01 | 0.062 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.671189e-01 | 0.062 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.671189e-01 | 0.062 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.688246e-01 | 0.061 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.721708e-01 | 0.059 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 8.738119e-01 | 0.059 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.754320e-01 | 0.058 |
| R-HSA-9758941 | Gastrulation | 8.832274e-01 | 0.054 |
| R-HSA-9609507 | Protein localization | 8.891127e-01 | 0.051 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.905372e-01 | 0.050 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.914719e-01 | 0.050 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.919436e-01 | 0.050 |
| R-HSA-162587 | HIV Life Cycle | 8.947026e-01 | 0.048 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.070668e-01 | 0.042 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.074808e-01 | 0.042 |
| R-HSA-5619102 | SLC transporter disorders | 9.074808e-01 | 0.042 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.121488e-01 | 0.040 |
| R-HSA-72306 | tRNA processing | 9.121488e-01 | 0.040 |
| R-HSA-418555 | G alpha (s) signalling events | 9.132787e-01 | 0.039 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.136072e-01 | 0.039 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.143942e-01 | 0.039 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.154953e-01 | 0.038 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.154953e-01 | 0.038 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.165824e-01 | 0.038 |
| R-HSA-449147 | Signaling by Interleukins | 9.188251e-01 | 0.037 |
| R-HSA-611105 | Respiratory electron transport | 9.207933e-01 | 0.036 |
| R-HSA-168255 | Influenza Infection | 9.218125e-01 | 0.035 |
| R-HSA-2559583 | Cellular Senescence | 9.228187e-01 | 0.035 |
| R-HSA-3781865 | Diseases of glycosylation | 9.267162e-01 | 0.033 |
| R-HSA-983712 | Ion channel transport | 9.313137e-01 | 0.031 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.347841e-01 | 0.029 |
| R-HSA-1474244 | Extracellular matrix organization | 9.403255e-01 | 0.027 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.404426e-01 | 0.027 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.497434e-01 | 0.022 |
| R-HSA-9748784 | Drug ADME | 9.534568e-01 | 0.021 |
| R-HSA-162906 | HIV Infection | 9.585915e-01 | 0.018 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.621919e-01 | 0.017 |
| R-HSA-8939211 | ESR-mediated signaling | 9.636379e-01 | 0.016 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.636379e-01 | 0.016 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.680720e-01 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.712097e-01 | 0.013 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.716004e-01 | 0.013 |
| R-HSA-416476 | G alpha (q) signalling events | 9.744094e-01 | 0.011 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.786760e-01 | 0.009 |
| R-HSA-9658195 | Leishmania infection | 9.794938e-01 | 0.009 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.794938e-01 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.951367e-01 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 9.961099e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.961099e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.970096e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.977372e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.990575e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.991578e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.996544e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998759e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.804 | 0.184 | 1 | 0.915 |
COT |
0.803 | 0.102 | 2 | 0.844 |
GRK1 |
0.802 | 0.206 | -2 | 0.772 |
NDR2 |
0.801 | 0.100 | -3 | 0.765 |
MOS |
0.798 | 0.179 | 1 | 0.910 |
CLK3 |
0.797 | 0.095 | 1 | 0.776 |
PIM3 |
0.796 | 0.099 | -3 | 0.770 |
RSK2 |
0.794 | 0.124 | -3 | 0.714 |
CAMK2B |
0.791 | 0.169 | 2 | 0.790 |
CAMK2A |
0.790 | 0.185 | 2 | 0.818 |
GRK6 |
0.790 | 0.197 | 1 | 0.885 |
PRKD1 |
0.789 | 0.094 | -3 | 0.727 |
CK1E |
0.788 | 0.216 | -3 | 0.725 |
CAMK1B |
0.788 | 0.087 | -3 | 0.764 |
SKMLCK |
0.787 | 0.076 | -2 | 0.832 |
CAMK2G |
0.787 | 0.121 | 2 | 0.813 |
PIM1 |
0.786 | 0.098 | -3 | 0.735 |
GRK7 |
0.786 | 0.171 | 1 | 0.820 |
MTOR |
0.786 | 0.088 | 1 | 0.755 |
BMPR1B |
0.786 | 0.164 | 1 | 0.919 |
GRK5 |
0.785 | 0.125 | -3 | 0.785 |
MAPKAPK2 |
0.784 | 0.080 | -3 | 0.669 |
IKKB |
0.784 | -0.012 | -2 | 0.690 |
NDR1 |
0.784 | 0.027 | -3 | 0.745 |
P90RSK |
0.784 | 0.078 | -3 | 0.713 |
KIS |
0.783 | 0.038 | 1 | 0.629 |
NUAK2 |
0.782 | 0.034 | -3 | 0.758 |
RSK4 |
0.782 | 0.110 | -3 | 0.702 |
CAMK2D |
0.782 | 0.093 | -3 | 0.730 |
CK2A2 |
0.781 | 0.155 | 1 | 0.871 |
PRKD2 |
0.781 | 0.068 | -3 | 0.695 |
PRPK |
0.781 | -0.054 | -1 | 0.814 |
CK1A2 |
0.781 | 0.221 | -3 | 0.694 |
CLK2 |
0.780 | 0.099 | -3 | 0.708 |
LATS2 |
0.780 | 0.043 | -5 | 0.758 |
GRK4 |
0.780 | 0.095 | -2 | 0.787 |
MSK1 |
0.780 | 0.108 | -3 | 0.685 |
PASK |
0.780 | 0.265 | -3 | 0.786 |
CK1D |
0.779 | 0.218 | -3 | 0.691 |
RAF1 |
0.779 | -0.056 | 1 | 0.832 |
PKN3 |
0.778 | 0.014 | -3 | 0.732 |
DSTYK |
0.778 | -0.031 | 2 | 0.858 |
SRPK1 |
0.778 | 0.028 | -3 | 0.710 |
PRKX |
0.778 | 0.105 | -3 | 0.655 |
AMPKA1 |
0.777 | 0.013 | -3 | 0.756 |
PDHK4 |
0.777 | -0.045 | 1 | 0.824 |
CDKL1 |
0.777 | 0.032 | -3 | 0.734 |
RSK3 |
0.777 | 0.055 | -3 | 0.695 |
PKACG |
0.776 | 0.041 | -2 | 0.721 |
CK2A1 |
0.775 | 0.159 | 1 | 0.859 |
IKKA |
0.775 | 0.018 | -2 | 0.678 |
ATR |
0.775 | 0.018 | 1 | 0.763 |
MSK2 |
0.775 | 0.058 | -3 | 0.695 |
MST4 |
0.775 | -0.008 | 2 | 0.842 |
AURC |
0.775 | 0.043 | -2 | 0.641 |
RIPK3 |
0.775 | -0.066 | 3 | 0.257 |
WNK1 |
0.774 | -0.006 | -2 | 0.839 |
HUNK |
0.774 | -0.061 | 2 | 0.805 |
PKACB |
0.774 | 0.073 | -2 | 0.663 |
DAPK2 |
0.774 | 0.043 | -3 | 0.764 |
GCN2 |
0.774 | -0.129 | 2 | 0.806 |
CAMLCK |
0.773 | 0.016 | -2 | 0.800 |
PKN2 |
0.773 | 0.015 | -3 | 0.737 |
AMPKA2 |
0.773 | 0.010 | -3 | 0.732 |
HIPK4 |
0.773 | 0.008 | 1 | 0.699 |
TGFBR1 |
0.772 | 0.069 | -2 | 0.744 |
P70S6KB |
0.772 | 0.032 | -3 | 0.717 |
TSSK2 |
0.772 | 0.028 | -5 | 0.893 |
ERK5 |
0.772 | -0.015 | 1 | 0.788 |
MARK4 |
0.772 | -0.034 | 4 | 0.826 |
NIK |
0.772 | -0.015 | -3 | 0.764 |
BMPR2 |
0.771 | -0.107 | -2 | 0.808 |
CK1G1 |
0.771 | 0.157 | -3 | 0.707 |
TSSK1 |
0.771 | 0.022 | -3 | 0.770 |
NLK |
0.771 | -0.050 | 1 | 0.776 |
MASTL |
0.771 | -0.038 | -2 | 0.758 |
DLK |
0.771 | 0.094 | 1 | 0.837 |
CDKL5 |
0.771 | 0.014 | -3 | 0.726 |
TBK1 |
0.770 | -0.114 | 1 | 0.708 |
FAM20C |
0.770 | 0.030 | 2 | 0.536 |
GRK2 |
0.770 | 0.100 | -2 | 0.673 |
LATS1 |
0.770 | 0.079 | -3 | 0.765 |
MAPKAPK3 |
0.769 | -0.000 | -3 | 0.687 |
GSK3A |
0.769 | 0.185 | 4 | 0.566 |
CAMK4 |
0.768 | 0.010 | -3 | 0.730 |
MYLK4 |
0.768 | 0.043 | -2 | 0.747 |
IKKE |
0.768 | -0.104 | 1 | 0.702 |
ACVR2B |
0.768 | 0.088 | -2 | 0.722 |
ICK |
0.768 | 0.012 | -3 | 0.759 |
ALK2 |
0.768 | 0.082 | -2 | 0.758 |
GSK3B |
0.767 | 0.176 | 4 | 0.556 |
ALK4 |
0.767 | 0.042 | -2 | 0.761 |
GRK3 |
0.767 | 0.112 | -2 | 0.646 |
BMPR1A |
0.767 | 0.114 | 1 | 0.902 |
SRPK3 |
0.767 | 0.010 | -3 | 0.688 |
SRPK2 |
0.767 | 0.020 | -3 | 0.647 |
AURA |
0.766 | 0.050 | -2 | 0.615 |
QSK |
0.766 | 0.001 | 4 | 0.795 |
NEK6 |
0.766 | -0.104 | -2 | 0.795 |
CDK1 |
0.766 | 0.037 | 1 | 0.594 |
CLK4 |
0.765 | 0.042 | -3 | 0.716 |
TGFBR2 |
0.765 | -0.084 | -2 | 0.728 |
PDHK1 |
0.765 | -0.153 | 1 | 0.799 |
ACVR2A |
0.765 | 0.064 | -2 | 0.699 |
NUAK1 |
0.764 | 0.000 | -3 | 0.702 |
NEK7 |
0.764 | -0.133 | -3 | 0.702 |
MLK1 |
0.764 | -0.074 | 2 | 0.783 |
CHAK2 |
0.764 | -0.078 | -1 | 0.791 |
NIM1 |
0.763 | -0.052 | 3 | 0.248 |
RIPK1 |
0.763 | -0.075 | 1 | 0.769 |
BCKDK |
0.762 | -0.101 | -1 | 0.770 |
PKCD |
0.762 | -0.038 | 2 | 0.751 |
AKT2 |
0.762 | 0.047 | -3 | 0.654 |
PRKD3 |
0.761 | 0.029 | -3 | 0.676 |
ATM |
0.761 | -0.025 | 1 | 0.700 |
DRAK1 |
0.761 | 0.048 | 1 | 0.850 |
PAK1 |
0.760 | -0.003 | -2 | 0.744 |
MEK1 |
0.760 | 0.027 | 2 | 0.824 |
CLK1 |
0.760 | 0.027 | -3 | 0.683 |
SIK |
0.760 | -0.006 | -3 | 0.691 |
BRSK1 |
0.760 | -0.026 | -3 | 0.707 |
CAMK1G |
0.760 | 0.034 | -3 | 0.691 |
ULK2 |
0.760 | -0.202 | 2 | 0.757 |
DYRK2 |
0.760 | -0.002 | 1 | 0.634 |
CK1A |
0.759 | 0.197 | -3 | 0.629 |
MNK2 |
0.759 | -0.021 | -2 | 0.761 |
PLK1 |
0.759 | -0.013 | -2 | 0.745 |
PKACA |
0.758 | 0.055 | -2 | 0.611 |
TTBK2 |
0.758 | -0.069 | 2 | 0.710 |
AURB |
0.758 | 0.008 | -2 | 0.638 |
MARK3 |
0.757 | -0.011 | 4 | 0.769 |
ANKRD3 |
0.757 | -0.097 | 1 | 0.824 |
PKCB |
0.757 | -0.025 | 2 | 0.709 |
MNK1 |
0.757 | -0.018 | -2 | 0.764 |
DNAPK |
0.756 | 0.048 | 1 | 0.595 |
SGK3 |
0.756 | 0.018 | -3 | 0.688 |
HIPK2 |
0.756 | 0.015 | 1 | 0.545 |
QIK |
0.755 | -0.067 | -3 | 0.732 |
DCAMKL1 |
0.755 | 0.012 | -3 | 0.711 |
PKCG |
0.755 | -0.037 | 2 | 0.707 |
CHK1 |
0.754 | 0.009 | -3 | 0.700 |
WNK3 |
0.754 | -0.195 | 1 | 0.764 |
PLK3 |
0.754 | -0.004 | 2 | 0.760 |
MELK |
0.754 | -0.057 | -3 | 0.709 |
CDK2 |
0.754 | -0.010 | 1 | 0.690 |
MEKK3 |
0.754 | 0.018 | 1 | 0.800 |
MARK2 |
0.754 | -0.028 | 4 | 0.744 |
CDK3 |
0.753 | -0.001 | 1 | 0.531 |
PIM2 |
0.753 | 0.024 | -3 | 0.686 |
YSK4 |
0.753 | -0.043 | 1 | 0.768 |
PKG2 |
0.753 | -0.003 | -2 | 0.655 |
CDK8 |
0.753 | -0.047 | 1 | 0.603 |
PKCA |
0.752 | -0.030 | 2 | 0.697 |
NEK9 |
0.752 | -0.164 | 2 | 0.825 |
GAK |
0.752 | 0.171 | 1 | 0.862 |
ULK1 |
0.752 | -0.169 | -3 | 0.655 |
HIPK1 |
0.752 | 0.008 | 1 | 0.651 |
JNK2 |
0.752 | 0.011 | 1 | 0.566 |
PAK3 |
0.752 | -0.058 | -2 | 0.740 |
DAPK1 |
0.752 | 0.082 | -3 | 0.730 |
CAMK1D |
0.752 | 0.041 | -3 | 0.638 |
PKR |
0.751 | -0.059 | 1 | 0.788 |
CDK18 |
0.751 | -0.004 | 1 | 0.554 |
MST3 |
0.751 | 0.035 | 2 | 0.820 |
PAK6 |
0.751 | 0.014 | -2 | 0.655 |
JNK3 |
0.751 | -0.001 | 1 | 0.599 |
MLK2 |
0.751 | -0.148 | 2 | 0.795 |
MAPKAPK5 |
0.751 | -0.029 | -3 | 0.639 |
BRSK2 |
0.751 | -0.069 | -3 | 0.714 |
CDK5 |
0.750 | -0.039 | 1 | 0.638 |
PHKG1 |
0.750 | -0.075 | -3 | 0.742 |
SMG1 |
0.750 | 0.000 | 1 | 0.693 |
MARK1 |
0.749 | -0.041 | 4 | 0.780 |
CDK7 |
0.749 | -0.050 | 1 | 0.620 |
PAK2 |
0.749 | -0.049 | -2 | 0.725 |
PKCZ |
0.749 | -0.066 | 2 | 0.755 |
IRE1 |
0.749 | -0.137 | 1 | 0.729 |
MLK3 |
0.749 | -0.081 | 2 | 0.713 |
CDK19 |
0.749 | -0.046 | 1 | 0.563 |
DYRK4 |
0.749 | 0.015 | 1 | 0.568 |
CDK13 |
0.748 | -0.046 | 1 | 0.587 |
DAPK3 |
0.748 | 0.050 | -3 | 0.735 |
PKCH |
0.748 | -0.053 | 2 | 0.690 |
VRK2 |
0.748 | -0.165 | 1 | 0.825 |
P38B |
0.748 | 0.008 | 1 | 0.591 |
P38A |
0.747 | -0.014 | 1 | 0.655 |
TLK2 |
0.746 | -0.049 | 1 | 0.721 |
SMMLCK |
0.746 | 0.005 | -3 | 0.726 |
P70S6K |
0.746 | 0.003 | -3 | 0.640 |
MLK4 |
0.746 | -0.075 | 2 | 0.688 |
PLK4 |
0.745 | -0.084 | 2 | 0.616 |
AKT1 |
0.744 | 0.016 | -3 | 0.661 |
CDK17 |
0.744 | -0.015 | 1 | 0.509 |
DCAMKL2 |
0.744 | -0.001 | -3 | 0.719 |
PLK2 |
0.744 | 0.062 | -3 | 0.649 |
TAO3 |
0.744 | -0.015 | 1 | 0.783 |
ERK1 |
0.743 | -0.028 | 1 | 0.573 |
P38G |
0.743 | -0.012 | 1 | 0.504 |
DYRK1A |
0.742 | -0.017 | 1 | 0.664 |
CDK12 |
0.742 | -0.044 | 1 | 0.557 |
MEK5 |
0.742 | -0.122 | 2 | 0.800 |
CDK9 |
0.742 | -0.061 | 1 | 0.594 |
SNRK |
0.741 | -0.149 | 2 | 0.642 |
GCK |
0.741 | 0.065 | 1 | 0.786 |
SSTK |
0.741 | -0.053 | 4 | 0.781 |
MPSK1 |
0.741 | 0.007 | 1 | 0.756 |
BRAF |
0.741 | -0.074 | -4 | 0.843 |
YANK3 |
0.740 | 0.092 | 2 | 0.402 |
CDK14 |
0.740 | -0.015 | 1 | 0.596 |
CHAK1 |
0.740 | -0.169 | 2 | 0.752 |
ZAK |
0.740 | -0.085 | 1 | 0.765 |
CDK10 |
0.740 | -0.003 | 1 | 0.579 |
WNK4 |
0.740 | -0.105 | -2 | 0.824 |
MEKK2 |
0.740 | -0.073 | 2 | 0.780 |
AKT3 |
0.740 | 0.035 | -3 | 0.608 |
SGK1 |
0.739 | 0.050 | -3 | 0.591 |
JNK1 |
0.739 | 0.007 | 1 | 0.568 |
NEK2 |
0.739 | -0.148 | 2 | 0.801 |
MEKK1 |
0.739 | -0.141 | 1 | 0.766 |
PRP4 |
0.739 | -0.029 | -3 | 0.663 |
HIPK3 |
0.738 | -0.036 | 1 | 0.644 |
DYRK1B |
0.738 | -0.021 | 1 | 0.596 |
CAMK1A |
0.738 | 0.036 | -3 | 0.607 |
DYRK3 |
0.737 | -0.006 | 1 | 0.649 |
IRE2 |
0.737 | -0.174 | 2 | 0.690 |
TLK1 |
0.737 | -0.076 | -2 | 0.775 |
NEK11 |
0.737 | -0.036 | 1 | 0.765 |
MAK |
0.735 | 0.037 | -2 | 0.663 |
NEK5 |
0.735 | -0.126 | 1 | 0.774 |
PAK4 |
0.735 | 0.005 | -2 | 0.609 |
CHK2 |
0.735 | 0.024 | -3 | 0.600 |
PAK5 |
0.735 | -0.012 | -2 | 0.600 |
ERK2 |
0.735 | -0.056 | 1 | 0.605 |
HPK1 |
0.735 | 0.030 | 1 | 0.764 |
PKCE |
0.734 | -0.020 | 2 | 0.691 |
SBK |
0.734 | 0.053 | -3 | 0.553 |
CDK16 |
0.733 | -0.013 | 1 | 0.523 |
P38D |
0.733 | -0.009 | 1 | 0.490 |
PKCT |
0.732 | -0.079 | 2 | 0.698 |
PERK |
0.732 | -0.179 | -2 | 0.759 |
PHKG2 |
0.732 | -0.087 | -3 | 0.704 |
PKCI |
0.732 | -0.062 | 2 | 0.719 |
PDK1 |
0.730 | -0.056 | 1 | 0.754 |
LKB1 |
0.730 | -0.080 | -3 | 0.694 |
EEF2K |
0.730 | -0.059 | 3 | 0.303 |
MRCKA |
0.729 | 0.015 | -3 | 0.682 |
IRAK4 |
0.728 | -0.171 | 1 | 0.728 |
CAMKK2 |
0.728 | -0.080 | -2 | 0.701 |
CK1G2 |
0.728 | 0.165 | -3 | 0.653 |
TTBK1 |
0.728 | -0.100 | 2 | 0.622 |
MST2 |
0.728 | -0.055 | 1 | 0.795 |
PKN1 |
0.728 | -0.027 | -3 | 0.655 |
CAMKK1 |
0.728 | -0.115 | -2 | 0.712 |
MAP3K15 |
0.727 | -0.070 | 1 | 0.744 |
TAK1 |
0.727 | 0.027 | 1 | 0.784 |
CK1G3 |
0.727 | 0.164 | -3 | 0.591 |
DMPK1 |
0.727 | 0.050 | -3 | 0.698 |
KHS2 |
0.727 | -0.010 | 1 | 0.747 |
HRI |
0.726 | -0.217 | -2 | 0.754 |
MRCKB |
0.726 | 0.000 | -3 | 0.671 |
MINK |
0.725 | -0.059 | 1 | 0.752 |
TAO2 |
0.725 | -0.125 | 2 | 0.818 |
PINK1 |
0.725 | -0.177 | 1 | 0.751 |
NEK8 |
0.725 | -0.150 | 2 | 0.784 |
ROCK2 |
0.725 | -0.003 | -3 | 0.713 |
BUB1 |
0.725 | 0.033 | -5 | 0.884 |
TNIK |
0.723 | -0.084 | 3 | 0.297 |
MEKK6 |
0.723 | -0.107 | 1 | 0.762 |
KHS1 |
0.722 | -0.043 | 1 | 0.731 |
CRIK |
0.721 | 0.041 | -3 | 0.660 |
LRRK2 |
0.721 | -0.095 | 2 | 0.827 |
STK33 |
0.721 | -0.069 | 2 | 0.609 |
PBK |
0.720 | 0.003 | 1 | 0.787 |
IRAK1 |
0.720 | -0.216 | -1 | 0.660 |
HGK |
0.720 | -0.109 | 3 | 0.305 |
PDHK3_TYR |
0.719 | 0.216 | 4 | 0.868 |
MOK |
0.719 | -0.009 | 1 | 0.671 |
ERK7 |
0.719 | -0.031 | 2 | 0.533 |
NEK4 |
0.719 | -0.164 | 1 | 0.731 |
VRK1 |
0.718 | -0.134 | 2 | 0.797 |
MST1 |
0.717 | -0.085 | 1 | 0.766 |
PDHK4_TYR |
0.715 | 0.192 | 2 | 0.849 |
NEK1 |
0.715 | -0.156 | 1 | 0.752 |
CDK6 |
0.715 | -0.069 | 1 | 0.568 |
SLK |
0.715 | -0.082 | -2 | 0.647 |
MAP2K6_TYR |
0.714 | 0.173 | -1 | 0.849 |
RIPK2 |
0.713 | -0.190 | 1 | 0.728 |
CDK4 |
0.713 | -0.070 | 1 | 0.543 |
LOK |
0.712 | -0.129 | -2 | 0.709 |
PKG1 |
0.711 | -0.031 | -2 | 0.588 |
MAP2K4_TYR |
0.711 | 0.121 | -1 | 0.837 |
YSK1 |
0.711 | -0.114 | 2 | 0.795 |
BMPR2_TYR |
0.710 | 0.137 | -1 | 0.851 |
PDHK1_TYR |
0.710 | 0.142 | -1 | 0.847 |
TTK |
0.709 | -0.062 | -2 | 0.762 |
OSR1 |
0.709 | -0.070 | 2 | 0.789 |
ROCK1 |
0.708 | -0.019 | -3 | 0.680 |
MEK2 |
0.708 | -0.198 | 2 | 0.798 |
YANK2 |
0.708 | 0.078 | 2 | 0.410 |
ALPHAK3 |
0.706 | 0.019 | -1 | 0.735 |
BIKE |
0.704 | 0.012 | 1 | 0.751 |
TESK1_TYR |
0.704 | -0.070 | 3 | 0.315 |
HASPIN |
0.702 | -0.059 | -1 | 0.649 |
PKMYT1_TYR |
0.702 | -0.067 | 3 | 0.296 |
MAP2K7_TYR |
0.701 | -0.093 | 2 | 0.832 |
ASK1 |
0.699 | -0.124 | 1 | 0.737 |
TXK |
0.699 | 0.027 | 1 | 0.938 |
FGR |
0.698 | 0.016 | 1 | 0.879 |
PINK1_TYR |
0.696 | -0.126 | 1 | 0.830 |
EPHA6 |
0.696 | -0.040 | -1 | 0.807 |
MYO3B |
0.695 | -0.114 | 2 | 0.797 |
EPHB4 |
0.693 | -0.073 | -1 | 0.769 |
EPHA4 |
0.693 | 0.003 | 2 | 0.752 |
NEK3 |
0.692 | -0.223 | 1 | 0.704 |
MYO3A |
0.692 | -0.120 | 1 | 0.713 |
FER |
0.691 | -0.047 | 1 | 0.898 |
INSRR |
0.691 | -0.092 | 3 | 0.231 |
FYN |
0.691 | 0.029 | -1 | 0.741 |
TAO1 |
0.690 | -0.158 | 1 | 0.689 |
AAK1 |
0.689 | 0.036 | 1 | 0.651 |
LIMK2_TYR |
0.689 | -0.148 | -3 | 0.747 |
YES1 |
0.688 | -0.078 | -1 | 0.744 |
DDR1 |
0.687 | -0.116 | 4 | 0.792 |
SRMS |
0.687 | -0.057 | 1 | 0.906 |
BLK |
0.687 | -0.040 | -1 | 0.759 |
EPHB1 |
0.687 | -0.083 | 1 | 0.889 |
PTK2 |
0.686 | 0.080 | -1 | 0.767 |
SYK |
0.686 | 0.099 | -1 | 0.759 |
ABL2 |
0.686 | -0.116 | -1 | 0.727 |
EPHB2 |
0.685 | -0.063 | -1 | 0.742 |
HCK |
0.685 | -0.102 | -1 | 0.743 |
RET |
0.685 | -0.216 | 1 | 0.767 |
ROS1 |
0.684 | -0.228 | 3 | 0.222 |
LCK |
0.684 | -0.074 | -1 | 0.752 |
STLK3 |
0.684 | -0.140 | 1 | 0.733 |
EPHB3 |
0.684 | -0.097 | -1 | 0.748 |
ABL1 |
0.683 | -0.098 | -1 | 0.709 |
MST1R |
0.683 | -0.229 | 3 | 0.240 |
ITK |
0.683 | -0.094 | -1 | 0.709 |
LIMK1_TYR |
0.683 | -0.232 | 2 | 0.818 |
TYRO3 |
0.683 | -0.229 | 3 | 0.237 |
TNK2 |
0.683 | -0.133 | 3 | 0.228 |
BMX |
0.682 | -0.057 | -1 | 0.650 |
JAK3 |
0.682 | -0.145 | 1 | 0.768 |
CSF1R |
0.681 | -0.196 | 3 | 0.224 |
TYK2 |
0.681 | -0.274 | 1 | 0.759 |
FLT1 |
0.680 | -0.032 | -1 | 0.790 |
MET |
0.680 | -0.098 | 3 | 0.230 |
FGFR2 |
0.680 | -0.120 | 3 | 0.280 |
MERTK |
0.679 | -0.115 | 3 | 0.226 |
EPHA7 |
0.679 | -0.067 | 2 | 0.750 |
EPHA3 |
0.679 | -0.063 | 2 | 0.724 |
JAK2 |
0.679 | -0.255 | 1 | 0.752 |
KDR |
0.678 | -0.147 | 3 | 0.224 |
KIT |
0.677 | -0.141 | 3 | 0.238 |
EPHA5 |
0.676 | -0.045 | 2 | 0.730 |
DDR2 |
0.676 | -0.072 | 3 | 0.240 |
SRC |
0.676 | -0.043 | -1 | 0.715 |
ERBB2 |
0.675 | -0.095 | 1 | 0.777 |
FGFR3 |
0.674 | -0.101 | 3 | 0.262 |
TEC |
0.674 | -0.120 | -1 | 0.630 |
NTRK1 |
0.674 | -0.155 | -1 | 0.759 |
EPHA8 |
0.673 | -0.063 | -1 | 0.746 |
LYN |
0.673 | -0.107 | 3 | 0.212 |
AXL |
0.673 | -0.180 | 3 | 0.229 |
PTK2B |
0.673 | -0.070 | -1 | 0.656 |
TEK |
0.672 | -0.209 | 3 | 0.220 |
ERBB4 |
0.672 | 0.001 | 1 | 0.744 |
PDGFRB |
0.671 | -0.234 | 3 | 0.240 |
FLT3 |
0.671 | -0.211 | 3 | 0.233 |
JAK1 |
0.670 | -0.177 | 1 | 0.709 |
NTRK3 |
0.670 | -0.123 | -1 | 0.719 |
WEE1_TYR |
0.670 | -0.101 | -1 | 0.684 |
FRK |
0.670 | -0.127 | -1 | 0.758 |
TNK1 |
0.670 | -0.198 | 3 | 0.230 |
TNNI3K_TYR |
0.670 | -0.143 | 1 | 0.751 |
ALK |
0.669 | -0.198 | 3 | 0.204 |
LTK |
0.669 | -0.172 | 3 | 0.220 |
FGFR1 |
0.669 | -0.214 | 3 | 0.228 |
INSR |
0.669 | -0.160 | 3 | 0.215 |
BTK |
0.668 | -0.196 | -1 | 0.661 |
EGFR |
0.668 | -0.040 | 1 | 0.708 |
FLT4 |
0.667 | -0.161 | 3 | 0.246 |
NEK10_TYR |
0.666 | -0.160 | 1 | 0.640 |
EPHA2 |
0.666 | -0.062 | -1 | 0.720 |
IGF1R |
0.666 | -0.104 | 3 | 0.200 |
EPHA1 |
0.665 | -0.186 | 3 | 0.211 |
NTRK2 |
0.665 | -0.213 | 3 | 0.224 |
CSK |
0.665 | -0.099 | 2 | 0.751 |
MATK |
0.663 | -0.098 | -1 | 0.666 |
FGFR4 |
0.663 | -0.068 | -1 | 0.697 |
PTK6 |
0.661 | -0.174 | -1 | 0.619 |
ZAP70 |
0.661 | 0.015 | -1 | 0.693 |
PDGFRA |
0.660 | -0.290 | 3 | 0.237 |
FES |
0.654 | -0.083 | -1 | 0.610 |
MUSK |
0.649 | -0.154 | 1 | 0.700 |