Motif 494 (n=203)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1583 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A7KAX9 | ARHGAP32 | S706 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A7KAX9 | ARHGAP32 | S709 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| O00165 | HAX1 | S192 | ochoa | HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1) | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16857965, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:18319618, ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:26997484, ECO:0000269|PubMed:9058808}. |
| O14715 | RGPD8 | S1582 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14920 | IKBKB | S692 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15055 | PER2 | S668 | psp | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15085 | ARHGEF11 | S242 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15164 | TRIM24 | S770 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O43182 | ARHGAP6 | S332 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43865 | AHCYL1 | S74 | psp | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}. |
| O60563 | CCNT1 | S566 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O75037 | KIF21B | S1261 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75128 | COBL | S284 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75164 | KDM4A | S517 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75473 | LGR5 | S854 | ochoa|psp | Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}. |
| O75940 | SMNDC1 | S63 | ochoa | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
| O94875 | SORBS2 | S245 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95235 | KIF20A | S44 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95251 | KAT7 | S99 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95251 | KAT7 | S164 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95696 | BRD1 | S505 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95772 | STARD3NL | S27 | ochoa | STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog) | Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}. |
| P00533 | EGFR | S1039 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02545 | LMNA | S426 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P04075 | ALDOA | S36 | ochoa|psp | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P07949 | RET | S832 | ochoa | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P09972 | ALDOC | S36 | ochoa | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P10636 | MAPT | S730 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S1799 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11388 | TOP2A | S1374 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12830 | CDH1 | S850 | psp | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
| P14921 | ETS1 | S282 | ochoa|psp | Protein C-ets-1 (p54) | Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000303|PubMed:20378371}.; FUNCTION: [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A. {ECO:0000269|PubMed:19377509}. |
| P16144 | ITGB4 | S1518 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P18846 | ATF1 | S47 | psp | Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| P22670 | RFX1 | S123 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P22681 | CBL | S648 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23677 | ITPKA | S127 | ochoa | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}. |
| P25054 | APC | S969 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25054 | APC | S1507 | psp | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P38398 | BRCA1 | S398 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41236 | PPP1R2 | S20 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P42685 | FRK | S40 | ochoa | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P45974 | USP5 | S159 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46937 | YAP1 | S403 | ochoa|psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P48634 | PRRC2A | S166 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48681 | NES | S1451 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49023 | PXN | S143 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49792 | RANBP2 | S2558 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P61925 | PKIA | S32 | ochoa | cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) | Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. |
| P78337 | PITX1 | S48 | ochoa | Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) | Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}. |
| P78527 | PRKDC | S3018 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q02952 | AKAP12 | S648 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S52 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04656 | ATP7A | S1466 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q04656 | ATP7A | S1473 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q05397 | PTK2 | S890 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q07157 | TJP1 | S300 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S834 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08AD1 | CAMSAP2 | S473 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S5860 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5867 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12767 | TMEM94 | S454 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12802 | AKAP13 | S1906 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13129 | RLF | S1236 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13428 | TCOF1 | S156 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13470 | TNK1 | S508 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q13615 | MTMR3 | S909 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q13796 | SHROOM2 | S180 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13835 | PKP1 | S229 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14005 | IL16 | S1080 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14160 | SCRIB | S1226 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14161 | GIT2 | S421 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14161 | GIT2 | S565 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14289 | PTK2B | S396 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14687 | GSE1 | S84 | ochoa | Genetic suppressor element 1 | None |
| Q14699 | RFTN1 | S171 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14980 | NUMA1 | S1853 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15036 | SNX17 | S437 | ochoa|psp | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15057 | ACAP2 | S581 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15398 | DLGAP5 | S627 | ochoa|psp | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15751 | HERC1 | S2726 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q15911 | ZFHX3 | S2804 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q2KJY2 | KIF26B | S1141 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q52LW3 | ARHGAP29 | S179 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53T59 | HS1BP3 | S150 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q59EK9 | RUNDC3A | S378 | ochoa | RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) | May act as an effector of RAP2A in neuronal cells. {ECO:0000250}. |
| Q5HYJ3 | FAM76B | S154 | ochoa | Protein FAM76B | Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448). {ECO:0000269|PubMed:37643469, ECO:0000269|PubMed:38421448}. |
| Q5JSH3 | WDR44 | S574 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5TGY3 | AHDC1 | S849 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VZ89 | DENND4C | S1553 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6IBW4 | NCAPH2 | S325 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6NXS1 | PPP1R2B | S20 | ochoa | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6PJG2 | MIDEAS | S645 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6Q0C0 | TRAF7 | S100 | ochoa | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). {ECO:0000250|UniProtKB:Q922B6, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:29961569, ECO:0000269|PubMed:37086853}. |
| Q6UUV7 | CRTC3 | S329 | ochoa|psp | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6VY07 | PACS1 | S423 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZS30 | NBEAL1 | S1336 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q7LBC6 | KDM3B | S1262 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z2W4 | ZC3HAV1 | S498 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z309 | PABIR2 | S33 | ochoa | PABIR family member 2 | None |
| Q7Z3J3 | RGPD4 | S1583 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86SQ0 | PHLDB2 | S934 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86TP1 | PRUNE1 | S399 | ochoa | Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}. |
| Q86UE8 | TLK2 | S35 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86UE8 | TLK2 | S38 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86UE8 | TLK2 | S41 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86UE8 | TLK2 | S44 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86VP3 | PACS2 | S340 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86YV5 | PRAG1 | S495 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q86YW5 | TREML1 | S205 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q86YW5 | TREML1 | S239 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IVT2 | MISP | S284 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8N3F8 | MICALL1 | S559 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8NDI1 | EHBP1 | S177 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFC6 | BOD1L1 | S1283 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHM5 | KDM2B | S480 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8NI77 | KIF18A | S687 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8NI77 | KIF18A | S838 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TBZ3 | WDR20 | S357 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TDJ6 | DMXL2 | S1140 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TDM6 | DLG5 | S938 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEV9 | SMCR8 | S489 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WUZ0 | BCL7C | S103 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
| Q8WWI1 | LMO7 | S252 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWI1 | LMO7 | S255 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WYL5 | SSH1 | S984 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92613 | JADE3 | S703 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92667 | AKAP1 | S592 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92997 | DVL3 | S570 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96BY6 | DOCK10 | S1295 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96JB2 | COG3 | S533 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96JM3 | CHAMP1 | S468 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JY6 | PDLIM2 | S206 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96JY6 | PDLIM2 | S266 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96KP1 | EXOC2 | S432 | ochoa | Exocyst complex component 2 (Exocyst complex component Sec5) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000269|PubMed:12459492, ECO:0000269|PubMed:32639540}. |
| Q96L91 | EP400 | S934 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96RL1 | UIMC1 | S139 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96SU4 | OSBPL9 | S344 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q96T23 | RSF1 | S1249 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99666 | RGPD5 | S1582 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99683 | MAP3K5 | S1231 | ochoa | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q9BR39 | JPH2 | S168 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BRR8 | GPATCH1 | S200 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BRX2 | PELO | S55 | ochoa | Protein pelota homolog (hPelota) (Protein Dom34 homolog) | Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}. |
| Q9BSQ5 | CCM2 | S248 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BSQ5 | CCM2 | S251 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BUH8 | BEGAIN | S200 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BXF6 | RAB11FIP5 | S367 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BZ29 | DOCK9 | S1261 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9BZL6 | PRKD2 | S206 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9C0B0 | UNK | S608 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0C7 | AMBRA1 | S639 | ochoa | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
| Q9C0D0 | PHACTR1 | S183 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9C0D5 | TANC1 | S1665 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H0D6 | XRN2 | S448 | ochoa | 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) | Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}. |
| Q9H4L5 | OSBPL3 | S197 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H6U6 | BCAS3 | S712 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H6W3 | RIOX1 | S63 | ochoa | Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}. |
| Q9H992 | MARCHF7 | S365 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9H9C1 | VIPAS39 | S93 | ochoa | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
| Q9HAW4 | CLSPN | S771 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HB20 | PLEKHA3 | S221 | ochoa | Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) | Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}. |
| Q9HDC5 | JPH1 | S171 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NRX5 | SERINC1 | S351 | ochoa | Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) | Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250|UniProtKB:Q7TNK0}. |
| Q9NW97 | TMEM51 | S163 | ochoa | Transmembrane protein 51 | None |
| Q9NZM3 | ITSN2 | S219 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9NZM3 | ITSN2 | S222 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P0J7 | KCMF1 | S186 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P2Q2 | FRMD4A | S374 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UBC2 | EPS15L1 | S241 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBC2 | EPS15L1 | S244 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBC2 | EPS15L1 | S250 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UGV2 | NDRG3 | S341 | ochoa | Protein NDRG3 (N-myc downstream-regulated gene 3 protein) | None |
| Q9UHC7 | MKRN1 | S133 | ochoa | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}. |
| Q9UJZ1 | STOML2 | S336 | ochoa | Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7) | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}. |
| Q9UKI8 | TLK1 | S100 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKV3 | ACIN1 | S895 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULH0 | KIDINS220 | S1365 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULH7 | MRTFB | S547 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9UMX1 | SUFU | S352 | ochoa|psp | Suppressor of fused homolog (SUFUH) | Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:27234298, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24217340, PubMed:24311597). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:24311597, PubMed:28965847). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:24311597, PubMed:28965847). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:24311597, PubMed:28965847). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:24311597, PubMed:28965847). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z0P7, ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:10564661, ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:12068298, ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:15367681, ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:28965847}. |
| Q9UQ84 | EXO1 | S607 | ochoa | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9Y294 | ASF1A | S175 | ochoa | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}. |
| Q9Y446 | PKP3 | S92 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4F3 | MARF1 | S953 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y4W2 | LAS1L | S520 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y520 | PRRC2C | S2032 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5P4 | CERT1 | S132 | ochoa|psp | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y5P4 | CERT1 | S141 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y5P4 | CERT1 | S147 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y6D5 | ARFGEF2 | S620 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6D6 | ARFGEF1 | S670 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6D6 | ARFGEF1 | S673 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6Q9 | NCOA3 | S863 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q15007 | WTAP | S278 | Sugiyama | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). {ECO:0000269|PubMed:12444081, ECO:0000269|PubMed:17088532, ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| P60174 | TPI1 | S198 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P08238 | HSP90AB1 | S474 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| O60566 | BUB1B | S697 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q9NZV7 | ZIM2 | S155 | Sugiyama | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| O15055 | PER2 | S671 | iPTMNet | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| P56645 | PER3 | S628 | SIGNOR|iPTMNet | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
| P53667 | LIMK1 | S313 | Sugiyama | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. |
| Q9BYP7 | WNK3 | S44 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 9.713197e-11 | 10.013 |
| R-HSA-75153 | Apoptotic execution phase | 2.738381e-09 | 8.563 |
| R-HSA-109581 | Apoptosis | 1.175359e-04 | 3.930 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.646058e-04 | 3.784 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.322309e-04 | 3.634 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 4.010550e-04 | 3.397 |
| R-HSA-5357801 | Programmed Cell Death | 6.722623e-04 | 3.172 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 7.964779e-04 | 3.099 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.106789e-03 | 2.956 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.557649e-03 | 2.341 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 4.781056e-03 | 2.320 |
| R-HSA-1640170 | Cell Cycle | 5.629782e-03 | 2.250 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.977969e-03 | 2.223 |
| R-HSA-3214842 | HDMs demethylate histones | 7.461154e-03 | 2.127 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.258893e-02 | 1.900 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.502014e-02 | 1.602 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.502014e-02 | 1.602 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 3.729561e-02 | 1.428 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.729561e-02 | 1.428 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 3.729561e-02 | 1.428 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.138704e-02 | 1.212 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 7.320682e-02 | 1.135 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.211332e-02 | 1.917 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 8.487847e-02 | 1.071 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.586347e-02 | 1.800 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.790115e-02 | 1.747 |
| R-HSA-176417 | Phosphorylation of Emi1 | 9.640385e-02 | 1.016 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 9.640385e-02 | 1.016 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 9.640385e-02 | 1.016 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.004323e-02 | 1.698 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.077848e-01 | 0.967 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.077848e-01 | 0.967 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.301205e-01 | 0.886 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.301205e-01 | 0.886 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.772244e-02 | 1.423 |
| R-HSA-170984 | ARMS-mediated activation | 1.410787e-01 | 0.851 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.410787e-01 | 0.851 |
| R-HSA-182971 | EGFR downregulation | 1.200685e-02 | 1.921 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 4.059909e-02 | 1.391 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.059909e-02 | 1.391 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 4.059909e-02 | 1.391 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.059909e-02 | 1.391 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.969954e-02 | 1.304 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.625849e-01 | 0.789 |
| R-HSA-4839744 | Signaling by APC mutants | 1.625849e-01 | 0.789 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.625849e-01 | 0.789 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.625849e-01 | 0.789 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.625849e-01 | 0.789 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.731362e-01 | 0.762 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 5.945578e-02 | 1.226 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.835552e-01 | 0.736 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.835552e-01 | 0.736 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.835552e-01 | 0.736 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.835552e-01 | 0.736 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.835552e-01 | 0.736 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 7.337921e-02 | 1.134 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.040028e-01 | 0.690 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.140347e-01 | 0.670 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.140347e-01 | 0.670 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.140347e-01 | 0.670 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 9.206654e-02 | 1.036 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.239408e-01 | 0.650 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.239408e-01 | 0.650 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.337226e-01 | 0.631 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.433817e-01 | 0.614 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.252648e-02 | 1.488 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.252648e-02 | 1.488 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.623380e-01 | 0.581 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.658645e-02 | 1.177 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.328326e-01 | 0.877 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.716381e-01 | 0.566 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.808216e-01 | 0.552 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.457499e-01 | 0.836 |
| R-HSA-774815 | Nucleosome assembly | 1.457499e-01 | 0.836 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.898898e-01 | 0.538 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.898898e-01 | 0.538 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.335523e-01 | 0.477 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.419588e-01 | 0.466 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.419588e-01 | 0.466 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.502597e-01 | 0.456 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.502597e-01 | 0.456 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.551957e-01 | 0.593 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 6.284293e-02 | 1.202 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.355579e-02 | 1.361 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.355579e-02 | 1.361 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.598664e-01 | 0.585 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.273414e-01 | 0.643 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.273414e-01 | 0.643 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.221929e-02 | 1.492 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.221929e-02 | 1.492 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.133404e-01 | 0.671 |
| R-HSA-177929 | Signaling by EGFR | 9.327739e-03 | 2.030 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.951454e-02 | 1.710 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.529197e-01 | 0.597 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.380013e-02 | 1.269 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.225973e-01 | 0.652 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.140347e-01 | 0.670 |
| R-HSA-180292 | GAB1 signalosome | 3.492832e-02 | 1.457 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 9.595557e-02 | 1.018 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.659007e-02 | 1.332 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.502083e-02 | 1.456 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.164175e-01 | 0.500 |
| R-HSA-191650 | Regulation of gap junction activity | 7.320682e-02 | 1.135 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.301205e-01 | 0.886 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.938435e-01 | 0.713 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.645381e-01 | 0.578 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.645381e-01 | 0.578 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 6.629396e-02 | 1.179 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.741910e-02 | 1.562 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.907277e-01 | 0.537 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.228678e-02 | 1.652 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.462896e-02 | 1.609 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.835552e-01 | 0.736 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 8.822554e-02 | 1.054 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.239408e-01 | 0.650 |
| R-HSA-9664420 | Killing mechanisms | 2.239408e-01 | 0.650 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.337226e-01 | 0.631 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.433817e-01 | 0.614 |
| R-HSA-1221632 | Meiotic synapsis | 1.813022e-01 | 0.742 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.502597e-01 | 0.456 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.294048e-01 | 0.482 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.529197e-01 | 0.597 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.140347e-01 | 0.670 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.753512e-02 | 1.111 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 9.206654e-02 | 1.036 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 9.640385e-02 | 1.016 |
| R-HSA-6798695 | Neutrophil degranulation | 2.616960e-01 | 0.582 |
| R-HSA-446728 | Cell junction organization | 1.791069e-01 | 0.747 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 8.822554e-02 | 1.054 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.492043e-01 | 0.826 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 2.040028e-01 | 0.690 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.239408e-01 | 0.650 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.458605e-01 | 0.609 |
| R-HSA-1500931 | Cell-Cell communication | 6.584176e-02 | 1.181 |
| R-HSA-5693538 | Homology Directed Repair | 8.827873e-02 | 1.054 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.432100e-02 | 1.265 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.265453e-02 | 1.645 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 4.941727e-02 | 1.306 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 7.320682e-02 | 1.135 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.640385e-02 | 1.016 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.518997e-01 | 0.818 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.518997e-01 | 0.818 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.731362e-01 | 0.762 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.731362e-01 | 0.762 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.731362e-01 | 0.762 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.938435e-01 | 0.713 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.140347e-01 | 0.670 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 9.206654e-02 | 1.036 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 9.595557e-02 | 1.018 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.337226e-01 | 0.631 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 2.433817e-01 | 0.614 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.164175e-01 | 0.500 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.030307e-02 | 1.153 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.866141e-01 | 0.729 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 4.059909e-02 | 1.391 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.433817e-01 | 0.614 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.529197e-01 | 0.597 |
| R-HSA-9620244 | Long-term potentiation | 3.250390e-01 | 0.488 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.093292e-02 | 1.149 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.716381e-01 | 0.566 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.119565e-01 | 0.951 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.049876e-02 | 1.297 |
| R-HSA-68875 | Mitotic Prophase | 2.885240e-02 | 1.540 |
| R-HSA-1500620 | Meiosis | 3.296536e-01 | 0.482 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.502597e-01 | 0.456 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.729561e-02 | 1.428 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 9.640385e-02 | 1.016 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.492832e-02 | 1.457 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.140347e-01 | 0.670 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.337226e-01 | 0.631 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.623380e-01 | 0.581 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.623380e-01 | 0.581 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.285881e-01 | 0.891 |
| R-HSA-4086400 | PCP/CE pathway | 2.972064e-01 | 0.527 |
| R-HSA-68877 | Mitotic Prometaphase | 1.336805e-01 | 0.874 |
| R-HSA-169893 | Prolonged ERK activation events | 2.239408e-01 | 0.650 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.813022e-01 | 0.742 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.390673e-02 | 1.027 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.250390e-01 | 0.488 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.250390e-01 | 0.488 |
| R-HSA-983189 | Kinesins | 1.143622e-02 | 1.942 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 9.989083e-02 | 1.000 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.140347e-01 | 0.670 |
| R-HSA-2028269 | Signaling by Hippo | 3.221929e-02 | 1.492 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.236726e-02 | 1.205 |
| R-HSA-8848021 | Signaling by PTK6 | 6.236726e-02 | 1.205 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.677751e-02 | 1.775 |
| R-HSA-68886 | M Phase | 7.264625e-02 | 1.139 |
| R-HSA-444821 | Relaxin receptors | 9.640385e-02 | 1.016 |
| R-HSA-199920 | CREB phosphorylation | 1.077848e-01 | 0.967 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.301205e-01 | 0.886 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.518997e-01 | 0.818 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.731362e-01 | 0.762 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.835552e-01 | 0.736 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.835552e-01 | 0.736 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.040028e-01 | 0.690 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.140347e-01 | 0.670 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.239408e-01 | 0.650 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.160593e-01 | 0.935 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.898898e-01 | 0.538 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 8.710780e-02 | 1.060 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.250390e-01 | 0.488 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.502597e-01 | 0.456 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.009956e-01 | 0.697 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.282043e-02 | 1.082 |
| R-HSA-5358508 | Mismatch Repair | 2.529197e-01 | 0.597 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.945578e-02 | 1.226 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.140347e-01 | 0.670 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.414149e-01 | 0.850 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.433817e-01 | 0.614 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.623380e-01 | 0.581 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 2.133404e-01 | 0.671 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.225973e-01 | 0.652 |
| R-HSA-194138 | Signaling by VEGF | 1.036541e-01 | 0.984 |
| R-HSA-9909396 | Circadian clock | 4.129942e-02 | 1.384 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.030621e-02 | 1.220 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.065391e-01 | 0.514 |
| R-HSA-8939211 | ESR-mediated signaling | 2.283018e-01 | 0.641 |
| R-HSA-69481 | G2/M Checkpoints | 1.076783e-01 | 0.968 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.237606e-01 | 0.490 |
| R-HSA-9675135 | Diseases of DNA repair | 1.501122e-01 | 0.824 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 8.817344e-03 | 2.055 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.040699e-02 | 1.983 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 9.640385e-02 | 1.016 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 9.640385e-02 | 1.016 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.228678e-02 | 1.652 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.190231e-01 | 0.924 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.410787e-01 | 0.851 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 4.659007e-02 | 1.332 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.625849e-01 | 0.789 |
| R-HSA-8949664 | Processing of SMDT1 | 1.938435e-01 | 0.713 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.040028e-01 | 0.690 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.140347e-01 | 0.670 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.140347e-01 | 0.670 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.433817e-01 | 0.614 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.433817e-01 | 0.614 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.716381e-01 | 0.566 |
| R-HSA-3214847 | HATs acetylate histones | 5.238142e-02 | 1.281 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.911888e-02 | 1.160 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.419588e-01 | 0.466 |
| R-HSA-6806834 | Signaling by MET | 3.065089e-01 | 0.514 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.552728e-01 | 0.593 |
| R-HSA-73894 | DNA Repair | 3.510432e-01 | 0.455 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.529197e-01 | 0.597 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.825022e-02 | 1.317 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.434418e-01 | 0.464 |
| R-HSA-2559583 | Cellular Senescence | 1.104001e-01 | 0.957 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.460204e-02 | 1.609 |
| R-HSA-449836 | Other interleukin signaling | 2.623380e-01 | 0.581 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.640558e-02 | 1.578 |
| R-HSA-70171 | Glycolysis | 5.380013e-02 | 1.269 |
| R-HSA-373755 | Semaphorin interactions | 6.236726e-02 | 1.205 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.087184e-01 | 0.680 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 9.640385e-02 | 1.016 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.410787e-01 | 0.851 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 4.059909e-02 | 1.391 |
| R-HSA-5689901 | Metalloprotease DUBs | 6.284293e-02 | 1.202 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.040028e-01 | 0.690 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.040028e-01 | 0.690 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.140347e-01 | 0.670 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.433817e-01 | 0.614 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.470590e-01 | 0.833 |
| R-HSA-199991 | Membrane Trafficking | 1.446610e-01 | 0.840 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.743994e-02 | 1.427 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.848651e-01 | 0.545 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.076863e-01 | 0.512 |
| R-HSA-70326 | Glucose metabolism | 8.644027e-02 | 1.063 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 4.659007e-02 | 1.332 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.433817e-01 | 0.614 |
| R-HSA-9830674 | Formation of the ureteric bud | 3.076863e-01 | 0.512 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.949517e-01 | 0.710 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.335523e-01 | 0.477 |
| R-HSA-4839726 | Chromatin organization | 2.229500e-02 | 1.652 |
| R-HSA-622312 | Inflammasomes | 3.502597e-01 | 0.456 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.300243e-01 | 0.638 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.248666e-02 | 1.904 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.988443e-01 | 0.525 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.968198e-02 | 1.224 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.306524e-01 | 0.481 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.040028e-01 | 0.690 |
| R-HSA-196108 | Pregnenolone biosynthesis | 2.716381e-01 | 0.566 |
| R-HSA-977347 | Serine metabolism | 2.898898e-01 | 0.538 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.419588e-01 | 0.466 |
| R-HSA-8852135 | Protein ubiquitination | 2.832200e-01 | 0.548 |
| R-HSA-162582 | Signal Transduction | 1.111715e-01 | 0.954 |
| R-HSA-70263 | Gluconeogenesis | 3.502083e-02 | 1.456 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.808216e-01 | 0.552 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.318855e-01 | 0.635 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.799240e-01 | 0.745 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.959794e-02 | 1.529 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.835552e-01 | 0.736 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.835552e-01 | 0.736 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.201646e-01 | 0.920 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.153027e-01 | 0.938 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.318855e-01 | 0.635 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.681342e-02 | 1.330 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.434696e-02 | 1.353 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.625849e-01 | 0.789 |
| R-HSA-9830364 | Formation of the nephric duct | 5.945578e-02 | 1.226 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.767852e-01 | 0.753 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.140347e-01 | 0.670 |
| R-HSA-9629569 | Protein hydroxylation | 2.716381e-01 | 0.566 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.152543e-01 | 0.667 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.535804e-01 | 0.596 |
| R-HSA-450294 | MAP kinase activation | 2.179645e-01 | 0.662 |
| R-HSA-68882 | Mitotic Anaphase | 8.140024e-02 | 1.089 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 7.700930e-02 | 1.113 |
| R-HSA-445144 | Signal transduction by L1 | 2.716381e-01 | 0.566 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.266442e-02 | 1.083 |
| R-HSA-1483255 | PI Metabolism | 1.736812e-01 | 0.760 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.007368e-02 | 1.522 |
| R-HSA-448424 | Interleukin-17 signaling | 2.598664e-01 | 0.585 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 5.288184e-02 | 1.277 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.250390e-01 | 0.488 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.645381e-01 | 0.578 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.644376e-01 | 0.784 |
| R-HSA-9830369 | Kidney development | 2.458605e-01 | 0.609 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.598664e-01 | 0.585 |
| R-HSA-9823730 | Formation of definitive endoderm | 4.059909e-02 | 1.391 |
| R-HSA-1538133 | G0 and Early G1 | 8.443440e-02 | 1.073 |
| R-HSA-3000170 | Syndecan interactions | 3.076863e-01 | 0.512 |
| R-HSA-3000157 | Laminin interactions | 3.250390e-01 | 0.488 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.972064e-01 | 0.527 |
| R-HSA-5688426 | Deubiquitination | 1.385337e-01 | 0.858 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.160593e-01 | 0.935 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.296536e-01 | 0.482 |
| R-HSA-264876 | Insulin processing | 3.419588e-01 | 0.466 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.738815e-01 | 0.562 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.785517e-01 | 0.555 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 9.595557e-02 | 1.018 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.623380e-01 | 0.581 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.434418e-01 | 0.464 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.938435e-01 | 0.713 |
| R-HSA-9833482 | PKR-mediated signaling | 3.065089e-01 | 0.514 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.414149e-01 | 0.850 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.164175e-01 | 0.500 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.164175e-01 | 0.500 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.767852e-01 | 0.753 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.419588e-01 | 0.466 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.065089e-01 | 0.514 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.388552e-01 | 0.470 |
| R-HSA-6783589 | Interleukin-6 family signaling | 3.164175e-01 | 0.500 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.388552e-01 | 0.470 |
| R-HSA-9758941 | Gastrulation | 3.547482e-01 | 0.450 |
| R-HSA-418990 | Adherens junctions interactions | 3.561701e-01 | 0.448 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.577696e-01 | 0.446 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.584564e-01 | 0.446 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.584564e-01 | 0.446 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.584564e-01 | 0.446 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.599258e-01 | 0.444 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.662142e-01 | 0.436 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.665503e-01 | 0.436 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.665503e-01 | 0.436 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.665503e-01 | 0.436 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.665503e-01 | 0.436 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.665503e-01 | 0.436 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.695253e-01 | 0.432 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.707334e-01 | 0.431 |
| R-HSA-391251 | Protein folding | 3.707334e-01 | 0.431 |
| R-HSA-73887 | Death Receptor Signaling | 3.718992e-01 | 0.430 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.718992e-01 | 0.430 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.745425e-01 | 0.426 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.745425e-01 | 0.426 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.745425e-01 | 0.426 |
| R-HSA-9612973 | Autophagy | 3.787375e-01 | 0.422 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.824343e-01 | 0.417 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.824343e-01 | 0.417 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.842132e-01 | 0.415 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.847393e-01 | 0.415 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.902271e-01 | 0.409 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.902271e-01 | 0.409 |
| R-HSA-354192 | Integrin signaling | 3.902271e-01 | 0.409 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.902271e-01 | 0.409 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.902271e-01 | 0.409 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.902271e-01 | 0.409 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.902271e-01 | 0.409 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.902271e-01 | 0.409 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.902271e-01 | 0.409 |
| R-HSA-9930044 | Nuclear RNA decay | 3.902271e-01 | 0.409 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.902271e-01 | 0.409 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.923663e-01 | 0.406 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.931310e-01 | 0.405 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.975682e-01 | 0.401 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.975682e-01 | 0.401 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.979220e-01 | 0.400 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.979220e-01 | 0.400 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.979220e-01 | 0.400 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.979220e-01 | 0.400 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.019904e-01 | 0.396 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.019904e-01 | 0.396 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.019904e-01 | 0.396 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.055203e-01 | 0.392 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 4.055203e-01 | 0.392 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.055203e-01 | 0.392 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.055203e-01 | 0.392 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.055203e-01 | 0.392 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 4.063974e-01 | 0.391 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.075641e-01 | 0.390 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.130231e-01 | 0.384 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.130231e-01 | 0.384 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 4.130231e-01 | 0.384 |
| R-HSA-187687 | Signalling to ERKs | 4.130231e-01 | 0.384 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.130231e-01 | 0.384 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.130231e-01 | 0.384 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.151644e-01 | 0.382 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.195238e-01 | 0.377 |
| R-HSA-8853659 | RET signaling | 4.204317e-01 | 0.376 |
| R-HSA-3371511 | HSF1 activation | 4.204317e-01 | 0.376 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.204317e-01 | 0.376 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.204317e-01 | 0.376 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.277473e-01 | 0.369 |
| R-HSA-4641258 | Degradation of DVL | 4.277473e-01 | 0.369 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.277473e-01 | 0.369 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.277473e-01 | 0.369 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.277473e-01 | 0.369 |
| R-HSA-8875878 | MET promotes cell motility | 4.349710e-01 | 0.362 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.349710e-01 | 0.362 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.367940e-01 | 0.360 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.393908e-01 | 0.357 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.421039e-01 | 0.354 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.421039e-01 | 0.354 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.421039e-01 | 0.354 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.421039e-01 | 0.354 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.421039e-01 | 0.354 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.453250e-01 | 0.351 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.453250e-01 | 0.351 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.491472e-01 | 0.348 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.491472e-01 | 0.348 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.491472e-01 | 0.348 |
| R-HSA-167169 | HIV Transcription Elongation | 4.491472e-01 | 0.348 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.491472e-01 | 0.348 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.491472e-01 | 0.348 |
| R-HSA-5260271 | Diseases of Immune System | 4.491472e-01 | 0.348 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.491472e-01 | 0.348 |
| R-HSA-3371568 | Attenuation phase | 4.491472e-01 | 0.348 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.491472e-01 | 0.348 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.491472e-01 | 0.348 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.495636e-01 | 0.347 |
| R-HSA-421270 | Cell-cell junction organization | 4.496743e-01 | 0.347 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.537841e-01 | 0.343 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.561020e-01 | 0.341 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.561020e-01 | 0.341 |
| R-HSA-9607240 | FLT3 Signaling | 4.561020e-01 | 0.341 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.579861e-01 | 0.339 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.579861e-01 | 0.339 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 4.579861e-01 | 0.339 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.629694e-01 | 0.334 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.629694e-01 | 0.334 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.629694e-01 | 0.334 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.629694e-01 | 0.334 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.629694e-01 | 0.334 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.629694e-01 | 0.334 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.697506e-01 | 0.328 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.704796e-01 | 0.327 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.721299e-01 | 0.326 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.764465e-01 | 0.322 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.764465e-01 | 0.322 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.764465e-01 | 0.322 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.828004e-01 | 0.316 |
| R-HSA-373752 | Netrin-1 signaling | 4.830583e-01 | 0.316 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.895870e-01 | 0.310 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.895870e-01 | 0.310 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.895870e-01 | 0.310 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.895870e-01 | 0.310 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.895870e-01 | 0.310 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.895870e-01 | 0.310 |
| R-HSA-983712 | Ion channel transport | 4.913580e-01 | 0.309 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.960336e-01 | 0.304 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.960336e-01 | 0.304 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.960336e-01 | 0.304 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.960336e-01 | 0.304 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.960336e-01 | 0.304 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.960336e-01 | 0.304 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.973786e-01 | 0.303 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.023992e-01 | 0.299 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.023992e-01 | 0.299 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.029391e-01 | 0.298 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.029391e-01 | 0.298 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.071180e-01 | 0.295 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.086848e-01 | 0.294 |
| R-HSA-3371556 | Cellular response to heat stress | 5.108526e-01 | 0.292 |
| R-HSA-73886 | Chromosome Maintenance | 5.108526e-01 | 0.292 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.147785e-01 | 0.288 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.147785e-01 | 0.288 |
| R-HSA-9766229 | Degradation of CDH1 | 5.148914e-01 | 0.288 |
| R-HSA-157858 | Gap junction trafficking and regulation | 5.148914e-01 | 0.288 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.186837e-01 | 0.285 |
| R-HSA-6809371 | Formation of the cornified envelope | 5.225680e-01 | 0.282 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.270715e-01 | 0.278 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.270715e-01 | 0.278 |
| R-HSA-912446 | Meiotic recombination | 5.270715e-01 | 0.278 |
| R-HSA-9658195 | Leishmania infection | 5.307786e-01 | 0.275 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.307786e-01 | 0.275 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.330469e-01 | 0.273 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.330469e-01 | 0.273 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.330469e-01 | 0.273 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.330469e-01 | 0.273 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.389472e-01 | 0.268 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.389472e-01 | 0.268 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.389472e-01 | 0.268 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.389472e-01 | 0.268 |
| R-HSA-72172 | mRNA Splicing | 5.408758e-01 | 0.267 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.416736e-01 | 0.266 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.447733e-01 | 0.264 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.505261e-01 | 0.259 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.514285e-01 | 0.259 |
| R-HSA-1474165 | Reproduction | 5.528815e-01 | 0.257 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.562066e-01 | 0.255 |
| R-HSA-5578775 | Ion homeostasis | 5.562066e-01 | 0.255 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.562066e-01 | 0.255 |
| R-HSA-75893 | TNF signaling | 5.562066e-01 | 0.255 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.562066e-01 | 0.255 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.562066e-01 | 0.255 |
| R-HSA-2262752 | Cellular responses to stress | 5.588757e-01 | 0.253 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.618156e-01 | 0.250 |
| R-HSA-1483257 | Phospholipid metabolism | 5.666012e-01 | 0.247 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.673541e-01 | 0.246 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.691028e-01 | 0.245 |
| R-HSA-191859 | snRNP Assembly | 5.728229e-01 | 0.242 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.728229e-01 | 0.242 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.728229e-01 | 0.242 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.728229e-01 | 0.242 |
| R-HSA-195721 | Signaling by WNT | 5.740820e-01 | 0.241 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.782229e-01 | 0.238 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.782229e-01 | 0.238 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.782783e-01 | 0.238 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.818195e-01 | 0.235 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.819507e-01 | 0.235 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.835550e-01 | 0.234 |
| R-HSA-112043 | PLC beta mediated events | 5.835550e-01 | 0.234 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.888201e-01 | 0.230 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.888201e-01 | 0.230 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.888201e-01 | 0.230 |
| R-HSA-9707616 | Heme signaling | 5.888201e-01 | 0.230 |
| R-HSA-6807070 | PTEN Regulation | 5.888366e-01 | 0.230 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.888366e-01 | 0.230 |
| R-HSA-1632852 | Macroautophagy | 5.957665e-01 | 0.225 |
| R-HSA-1280218 | Adaptive Immune System | 5.979548e-01 | 0.223 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.026091e-01 | 0.220 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.042346e-01 | 0.219 |
| R-HSA-162906 | HIV Infection | 6.069748e-01 | 0.217 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.092259e-01 | 0.215 |
| R-HSA-112040 | G-protein mediated events | 6.141679e-01 | 0.212 |
| R-HSA-196071 | Metabolism of steroid hormones | 6.141679e-01 | 0.212 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.160324e-01 | 0.210 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.190477e-01 | 0.208 |
| R-HSA-167172 | Transcription of the HIV genome | 6.190477e-01 | 0.208 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.226133e-01 | 0.206 |
| R-HSA-166520 | Signaling by NTRKs | 6.226133e-01 | 0.206 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.286238e-01 | 0.202 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.286238e-01 | 0.202 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.333217e-01 | 0.198 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.333217e-01 | 0.198 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.355145e-01 | 0.197 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.379604e-01 | 0.195 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.379604e-01 | 0.195 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.379604e-01 | 0.195 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.379604e-01 | 0.195 |
| R-HSA-157118 | Signaling by NOTCH | 6.414464e-01 | 0.193 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.418353e-01 | 0.193 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.425407e-01 | 0.192 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.425407e-01 | 0.192 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.425407e-01 | 0.192 |
| R-HSA-9675108 | Nervous system development | 6.447558e-01 | 0.191 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.470633e-01 | 0.189 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.470633e-01 | 0.189 |
| R-HSA-162587 | HIV Life Cycle | 6.511549e-01 | 0.186 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.515290e-01 | 0.186 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.515290e-01 | 0.186 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.542185e-01 | 0.184 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.602817e-01 | 0.180 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.602924e-01 | 0.180 |
| R-HSA-216083 | Integrin cell surface interactions | 6.645915e-01 | 0.177 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.730280e-01 | 0.172 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.749570e-01 | 0.171 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.771667e-01 | 0.169 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.812532e-01 | 0.167 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.812532e-01 | 0.167 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.892726e-01 | 0.162 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.893929e-01 | 0.162 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.921207e-01 | 0.160 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.932066e-01 | 0.159 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.948904e-01 | 0.158 |
| R-HSA-109582 | Hemostasis | 6.951460e-01 | 0.158 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.970911e-01 | 0.157 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.009267e-01 | 0.154 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 7.009267e-01 | 0.154 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.084534e-01 | 0.150 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.084534e-01 | 0.150 |
| R-HSA-1236974 | ER-Phagosome pathway | 7.121457e-01 | 0.147 |
| R-HSA-202424 | Downstream TCR signaling | 7.157916e-01 | 0.145 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.193914e-01 | 0.143 |
| R-HSA-422475 | Axon guidance | 7.252336e-01 | 0.140 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.299211e-01 | 0.137 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.299211e-01 | 0.137 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.333428e-01 | 0.135 |
| R-HSA-1474290 | Collagen formation | 7.333428e-01 | 0.135 |
| R-HSA-69275 | G2/M Transition | 7.340184e-01 | 0.134 |
| R-HSA-168249 | Innate Immune System | 7.379886e-01 | 0.132 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.389017e-01 | 0.131 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.389017e-01 | 0.131 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.433514e-01 | 0.129 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.433514e-01 | 0.129 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.460836e-01 | 0.127 |
| R-HSA-190236 | Signaling by FGFR | 7.498152e-01 | 0.125 |
| R-HSA-422356 | Regulation of insulin secretion | 7.498152e-01 | 0.125 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.561170e-01 | 0.121 |
| R-HSA-9609690 | HCMV Early Events | 7.576787e-01 | 0.121 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.592084e-01 | 0.120 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.622608e-01 | 0.118 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.622608e-01 | 0.118 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.622608e-01 | 0.118 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.634002e-01 | 0.117 |
| R-HSA-1266738 | Developmental Biology | 7.645411e-01 | 0.117 |
| R-HSA-111885 | Opioid Signalling | 7.682505e-01 | 0.114 |
| R-HSA-428157 | Sphingolipid metabolism | 7.688158e-01 | 0.114 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.711889e-01 | 0.113 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.711889e-01 | 0.113 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.731450e-01 | 0.112 |
| R-HSA-69239 | Synthesis of DNA | 7.797833e-01 | 0.108 |
| R-HSA-211000 | Gene Silencing by RNA | 7.797833e-01 | 0.108 |
| R-HSA-6805567 | Keratinization | 7.815927e-01 | 0.107 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.825761e-01 | 0.106 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.825761e-01 | 0.106 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.853336e-01 | 0.105 |
| R-HSA-202403 | TCR signaling | 7.880564e-01 | 0.103 |
| R-HSA-6803157 | Antimicrobial peptides | 7.907448e-01 | 0.102 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.937492e-01 | 0.100 |
| R-HSA-397014 | Muscle contraction | 7.937492e-01 | 0.100 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.061771e-01 | 0.094 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.061771e-01 | 0.094 |
| R-HSA-373760 | L1CAM interactions | 8.086367e-01 | 0.092 |
| R-HSA-8951664 | Neddylation | 8.108683e-01 | 0.091 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.110653e-01 | 0.091 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.110653e-01 | 0.091 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.110653e-01 | 0.091 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.113378e-01 | 0.091 |
| R-HSA-8957322 | Metabolism of steroids | 8.128879e-01 | 0.090 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.134632e-01 | 0.090 |
| R-HSA-168256 | Immune System | 8.157975e-01 | 0.088 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.158307e-01 | 0.088 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.250058e-01 | 0.084 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.250058e-01 | 0.084 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.250146e-01 | 0.084 |
| R-HSA-72312 | rRNA processing | 8.300709e-01 | 0.081 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.315872e-01 | 0.080 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.315872e-01 | 0.080 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.315872e-01 | 0.080 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.337258e-01 | 0.079 |
| R-HSA-114608 | Platelet degranulation | 8.358374e-01 | 0.078 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.420134e-01 | 0.075 |
| R-HSA-9843745 | Adipogenesis | 8.460017e-01 | 0.073 |
| R-HSA-5576891 | Cardiac conduction | 8.460017e-01 | 0.073 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.479581e-01 | 0.072 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.498898e-01 | 0.071 |
| R-HSA-212436 | Generic Transcription Pathway | 8.528763e-01 | 0.069 |
| R-HSA-8953854 | Metabolism of RNA | 8.535693e-01 | 0.069 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.554407e-01 | 0.068 |
| R-HSA-163685 | Integration of energy metabolism | 8.573754e-01 | 0.067 |
| R-HSA-9609646 | HCMV Infection | 8.577435e-01 | 0.067 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.609777e-01 | 0.065 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.609777e-01 | 0.065 |
| R-HSA-9664407 | Parasite infection | 8.644894e-01 | 0.063 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.644894e-01 | 0.063 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.644894e-01 | 0.063 |
| R-HSA-112316 | Neuronal System | 8.693098e-01 | 0.061 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.728873e-01 | 0.059 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.776753e-01 | 0.057 |
| R-HSA-69242 | S Phase | 8.792311e-01 | 0.056 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.812571e-01 | 0.055 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.822838e-01 | 0.054 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.837813e-01 | 0.054 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.852598e-01 | 0.053 |
| R-HSA-69306 | DNA Replication | 8.867195e-01 | 0.052 |
| R-HSA-913531 | Interferon Signaling | 8.880282e-01 | 0.052 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.882647e-01 | 0.051 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.895839e-01 | 0.051 |
| R-HSA-1989781 | PPARA activates gene expression | 8.895839e-01 | 0.051 |
| R-HSA-74160 | Gene expression (Transcription) | 8.907089e-01 | 0.050 |
| R-HSA-9610379 | HCMV Late Events | 8.923761e-01 | 0.049 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.923761e-01 | 0.049 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.947683e-01 | 0.048 |
| R-HSA-5619102 | SLC transporter disorders | 9.053178e-01 | 0.043 |
| R-HSA-72306 | tRNA processing | 9.100497e-01 | 0.041 |
| R-HSA-418555 | G alpha (s) signalling events | 9.111955e-01 | 0.040 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.123267e-01 | 0.040 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.134436e-01 | 0.039 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.134436e-01 | 0.039 |
| R-HSA-449147 | Signaling by Interleukins | 9.148237e-01 | 0.039 |
| R-HSA-168255 | Influenza Infection | 9.198537e-01 | 0.036 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.263788e-01 | 0.033 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.267373e-01 | 0.033 |
| R-HSA-5617833 | Cilium Assembly | 9.304033e-01 | 0.031 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.305371e-01 | 0.031 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.326917e-01 | 0.030 |
| R-HSA-9679506 | SARS-CoV Infections | 9.358413e-01 | 0.029 |
| R-HSA-1474244 | Extracellular matrix organization | 9.381336e-01 | 0.028 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.387890e-01 | 0.027 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.403414e-01 | 0.027 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.411028e-01 | 0.026 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.669863e-01 | 0.015 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.706012e-01 | 0.013 |
| R-HSA-416476 | G alpha (q) signalling events | 9.734823e-01 | 0.012 |
| R-HSA-388396 | GPCR downstream signalling | 9.747537e-01 | 0.011 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.778644e-01 | 0.010 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.870453e-01 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 9.878825e-01 | 0.005 |
| R-HSA-9824446 | Viral Infection Pathways | 9.916815e-01 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 9.917873e-01 | 0.004 |
| R-HSA-5663205 | Infectious disease | 9.935169e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.937911e-01 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.951382e-01 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 9.958946e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.961958e-01 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.966230e-01 | 0.001 |
| R-HSA-72766 | Translation | 9.969174e-01 | 0.001 |
| R-HSA-1643685 | Disease | 9.988700e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.990979e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.993821e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.996210e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.997414e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1E |
0.764 | 0.323 | -3 | 0.735 |
COT |
0.762 | 0.082 | 2 | 0.860 |
CK1D |
0.762 | 0.339 | -3 | 0.725 |
CK1A2 |
0.759 | 0.335 | -3 | 0.725 |
GRK1 |
0.759 | 0.183 | -2 | 0.830 |
CK1G1 |
0.753 | 0.280 | -3 | 0.725 |
CDC7 |
0.753 | 0.125 | 1 | 0.885 |
GRK6 |
0.749 | 0.206 | 1 | 0.879 |
NDR2 |
0.749 | 0.001 | -3 | 0.528 |
MOS |
0.748 | 0.115 | 1 | 0.873 |
PRKD1 |
0.746 | 0.169 | -3 | 0.467 |
CLK3 |
0.745 | 0.038 | 1 | 0.789 |
GRK4 |
0.745 | 0.154 | -2 | 0.837 |
CK1A |
0.744 | 0.296 | -3 | 0.703 |
BMPR1B |
0.744 | 0.155 | 1 | 0.873 |
KIS |
0.744 | 0.072 | 1 | 0.635 |
CAMK2B |
0.744 | 0.139 | 2 | 0.811 |
GRK5 |
0.743 | 0.150 | -3 | 0.594 |
GRK7 |
0.743 | 0.147 | 1 | 0.790 |
IKKB |
0.741 | 0.004 | -2 | 0.706 |
CAMK2A |
0.741 | 0.138 | 2 | 0.824 |
CAMK2G |
0.741 | 0.086 | 2 | 0.820 |
DSTYK |
0.739 | -0.000 | 2 | 0.871 |
MAPKAPK2 |
0.739 | 0.038 | -3 | 0.442 |
PIM3 |
0.738 | -0.022 | -3 | 0.523 |
IKKA |
0.738 | 0.024 | -2 | 0.703 |
RSK2 |
0.738 | 0.025 | -3 | 0.447 |
PRKD2 |
0.737 | 0.086 | -3 | 0.446 |
RAF1 |
0.737 | -0.008 | 1 | 0.862 |
MTOR |
0.737 | 0.027 | 1 | 0.766 |
CAMK1B |
0.736 | 0.060 | -3 | 0.510 |
FAM20C |
0.735 | 0.053 | 2 | 0.594 |
GRK3 |
0.735 | 0.151 | -2 | 0.706 |
NUAK2 |
0.734 | 0.036 | -3 | 0.511 |
PRPK |
0.733 | -0.067 | -1 | 0.829 |
PDHK4 |
0.733 | -0.022 | 1 | 0.850 |
GCN2 |
0.732 | -0.085 | 2 | 0.794 |
CAMK2D |
0.732 | 0.077 | -3 | 0.475 |
LATS2 |
0.732 | -0.032 | -5 | 0.312 |
PIM1 |
0.732 | 0.016 | -3 | 0.504 |
GRK2 |
0.731 | 0.120 | -2 | 0.726 |
ATR |
0.731 | 0.021 | 1 | 0.825 |
P90RSK |
0.730 | 0.005 | -3 | 0.445 |
TSSK2 |
0.730 | 0.155 | -5 | 0.539 |
SKMLCK |
0.730 | -0.007 | -2 | 0.801 |
IKKE |
0.730 | -0.039 | 1 | 0.767 |
BMPR1A |
0.730 | 0.124 | 1 | 0.857 |
TBK1 |
0.730 | -0.051 | 1 | 0.760 |
BMPR2 |
0.730 | -0.029 | -2 | 0.836 |
NDR1 |
0.729 | -0.059 | -3 | 0.506 |
PKN3 |
0.728 | -0.011 | -3 | 0.479 |
RIPK3 |
0.728 | -0.028 | 3 | 0.448 |
MLK1 |
0.728 | -0.002 | 2 | 0.789 |
ATM |
0.728 | 0.032 | 1 | 0.780 |
RSK4 |
0.727 | 0.007 | -3 | 0.450 |
TSSK1 |
0.727 | 0.104 | -3 | 0.517 |
TGFBR2 |
0.727 | -0.029 | -2 | 0.787 |
CDKL1 |
0.727 | -0.024 | -3 | 0.467 |
MST4 |
0.727 | -0.011 | 2 | 0.845 |
ACVR2B |
0.727 | 0.094 | -2 | 0.779 |
ACVR2A |
0.727 | 0.103 | -2 | 0.765 |
DLK |
0.726 | 0.096 | 1 | 0.853 |
TGFBR1 |
0.726 | 0.060 | -2 | 0.789 |
CK2A2 |
0.726 | 0.110 | 1 | 0.770 |
PKN2 |
0.726 | 0.010 | -3 | 0.504 |
NLK |
0.726 | -0.024 | 1 | 0.797 |
NEK7 |
0.726 | -0.074 | -3 | 0.491 |
BCKDK |
0.725 | -0.035 | -1 | 0.836 |
AMPKA1 |
0.725 | 0.013 | -3 | 0.515 |
ALK2 |
0.725 | 0.087 | -2 | 0.810 |
WNK1 |
0.724 | -0.004 | -2 | 0.812 |
MSK1 |
0.724 | 0.028 | -3 | 0.442 |
MAPKAPK3 |
0.724 | -0.009 | -3 | 0.449 |
PASK |
0.724 | 0.151 | -3 | 0.534 |
SRPK1 |
0.724 | -0.027 | -3 | 0.450 |
PDHK1 |
0.724 | -0.084 | 1 | 0.839 |
MARK4 |
0.723 | -0.019 | 4 | 0.872 |
ERK5 |
0.723 | -0.013 | 1 | 0.753 |
NEK6 |
0.723 | -0.080 | -2 | 0.820 |
CK1G3 |
0.723 | 0.278 | -3 | 0.681 |
NIK |
0.722 | -0.014 | -3 | 0.527 |
PRKD3 |
0.722 | 0.088 | -3 | 0.427 |
ALK4 |
0.722 | 0.051 | -2 | 0.807 |
PKACG |
0.722 | -0.025 | -2 | 0.683 |
RSK3 |
0.722 | -0.030 | -3 | 0.432 |
CLK2 |
0.722 | 0.017 | -3 | 0.469 |
PRKX |
0.722 | 0.014 | -3 | 0.435 |
MSK2 |
0.721 | -0.010 | -3 | 0.450 |
LATS1 |
0.721 | -0.003 | -3 | 0.515 |
CAMK4 |
0.720 | 0.023 | -3 | 0.501 |
DAPK2 |
0.720 | -0.019 | -3 | 0.503 |
HUNK |
0.720 | -0.074 | 2 | 0.779 |
AMPKA2 |
0.720 | -0.002 | -3 | 0.492 |
CK2A1 |
0.720 | 0.115 | 1 | 0.755 |
CHK1 |
0.720 | 0.114 | -3 | 0.469 |
CAMLCK |
0.719 | -0.038 | -2 | 0.782 |
SRPK3 |
0.719 | -0.026 | -3 | 0.441 |
GSK3A |
0.719 | 0.134 | 4 | 0.607 |
CDK1 |
0.719 | 0.034 | 1 | 0.597 |
MASTL |
0.718 | -0.072 | -2 | 0.761 |
PLK1 |
0.718 | 0.001 | -2 | 0.777 |
PKACB |
0.718 | -0.008 | -2 | 0.617 |
SRPK2 |
0.718 | -0.037 | -3 | 0.402 |
NUAK1 |
0.717 | 0.014 | -3 | 0.466 |
P70S6KB |
0.717 | -0.054 | -3 | 0.466 |
ULK2 |
0.716 | -0.163 | 2 | 0.753 |
CDKL5 |
0.716 | -0.037 | -3 | 0.453 |
MYLK4 |
0.716 | 0.011 | -2 | 0.706 |
GSK3B |
0.716 | 0.136 | 4 | 0.599 |
ANKRD3 |
0.716 | -0.034 | 1 | 0.853 |
QSK |
0.716 | 0.005 | 4 | 0.842 |
TTBK2 |
0.715 | -0.032 | 2 | 0.673 |
ICK |
0.715 | -0.029 | -3 | 0.492 |
DNAPK |
0.715 | 0.057 | 1 | 0.721 |
RIPK1 |
0.715 | -0.036 | 1 | 0.797 |
HIPK4 |
0.715 | -0.034 | 1 | 0.758 |
CK1G2 |
0.715 | 0.243 | -3 | 0.709 |
AURA |
0.715 | 0.010 | -2 | 0.590 |
AURC |
0.715 | -0.017 | -2 | 0.606 |
SIK |
0.715 | 0.000 | -3 | 0.458 |
MEKK3 |
0.714 | 0.077 | 1 | 0.815 |
CLK4 |
0.714 | -0.008 | -3 | 0.471 |
TLK2 |
0.713 | 0.006 | 1 | 0.826 |
CHAK2 |
0.713 | -0.080 | -1 | 0.805 |
PKCD |
0.712 | -0.064 | 2 | 0.758 |
ULK1 |
0.712 | -0.132 | -3 | 0.467 |
PLK3 |
0.712 | -0.001 | 2 | 0.757 |
CAMK1G |
0.711 | 0.028 | -3 | 0.444 |
MEK1 |
0.711 | 0.035 | 2 | 0.807 |
MARK3 |
0.711 | 0.012 | 4 | 0.828 |
MLK4 |
0.711 | -0.016 | 2 | 0.697 |
WNK3 |
0.711 | -0.154 | 1 | 0.811 |
SMG1 |
0.710 | 0.024 | 1 | 0.769 |
YSK4 |
0.710 | -0.025 | 1 | 0.793 |
MLK3 |
0.710 | -0.042 | 2 | 0.713 |
NEK9 |
0.710 | -0.119 | 2 | 0.817 |
BRSK1 |
0.710 | -0.050 | -3 | 0.467 |
CDK8 |
0.709 | -0.029 | 1 | 0.629 |
TLK1 |
0.709 | 0.038 | -2 | 0.813 |
MARK2 |
0.709 | 0.005 | 4 | 0.792 |
DRAK1 |
0.709 | 0.007 | 1 | 0.823 |
QIK |
0.708 | -0.022 | -3 | 0.481 |
CLK1 |
0.707 | -0.023 | -3 | 0.437 |
NIM1 |
0.707 | -0.086 | 3 | 0.447 |
AKT2 |
0.707 | -0.026 | -3 | 0.410 |
MNK2 |
0.707 | -0.031 | -2 | 0.711 |
PLK2 |
0.707 | 0.052 | -3 | 0.487 |
PKR |
0.706 | -0.043 | 1 | 0.817 |
CDK2 |
0.706 | -0.002 | 1 | 0.687 |
CAMK1D |
0.706 | 0.034 | -3 | 0.413 |
PKCB |
0.706 | -0.057 | 2 | 0.711 |
MLK2 |
0.705 | -0.129 | 2 | 0.793 |
PAK1 |
0.704 | -0.066 | -2 | 0.709 |
MNK1 |
0.704 | -0.040 | -2 | 0.719 |
MELK |
0.704 | -0.041 | -3 | 0.464 |
DYRK2 |
0.704 | -0.031 | 1 | 0.663 |
IRE1 |
0.703 | -0.085 | 1 | 0.758 |
CDK19 |
0.703 | -0.032 | 1 | 0.586 |
AURB |
0.703 | -0.029 | -2 | 0.603 |
MARK1 |
0.703 | -0.014 | 4 | 0.837 |
MAPKAPK5 |
0.703 | -0.045 | -3 | 0.393 |
JNK3 |
0.703 | -0.005 | 1 | 0.609 |
PKCG |
0.703 | -0.069 | 2 | 0.703 |
JNK2 |
0.702 | 0.010 | 1 | 0.578 |
BRSK2 |
0.702 | -0.063 | -3 | 0.474 |
MST3 |
0.702 | 0.027 | 2 | 0.812 |
PHKG1 |
0.701 | -0.062 | -3 | 0.504 |
PKACA |
0.701 | -0.019 | -2 | 0.564 |
GAK |
0.701 | 0.093 | 1 | 0.800 |
PKCH |
0.700 | -0.065 | 2 | 0.689 |
VRK2 |
0.700 | -0.145 | 1 | 0.846 |
PKCA |
0.700 | -0.063 | 2 | 0.697 |
P38B |
0.699 | 0.016 | 1 | 0.582 |
BRAF |
0.699 | -0.056 | -4 | 0.817 |
TAO3 |
0.699 | -0.020 | 1 | 0.798 |
CDK18 |
0.699 | -0.000 | 1 | 0.548 |
PKG2 |
0.699 | -0.049 | -2 | 0.615 |
CDK5 |
0.699 | -0.037 | 1 | 0.644 |
ZAK |
0.699 | -0.035 | 1 | 0.798 |
SGK3 |
0.698 | -0.059 | -3 | 0.442 |
P38A |
0.698 | -0.001 | 1 | 0.648 |
DCAMKL1 |
0.698 | -0.051 | -3 | 0.477 |
MEKK2 |
0.698 | -0.016 | 2 | 0.780 |
HIPK2 |
0.698 | -0.019 | 1 | 0.568 |
CDK3 |
0.697 | -0.005 | 1 | 0.524 |
YANK3 |
0.697 | 0.105 | 2 | 0.386 |
PIM2 |
0.697 | -0.063 | -3 | 0.433 |
DAPK1 |
0.697 | 0.015 | -3 | 0.485 |
MEK5 |
0.697 | -0.073 | 2 | 0.795 |
GCK |
0.696 | 0.046 | 1 | 0.835 |
PAK3 |
0.696 | -0.104 | -2 | 0.698 |
SMMLCK |
0.696 | -0.032 | -3 | 0.470 |
CDK7 |
0.696 | -0.049 | 1 | 0.628 |
CAMK1A |
0.696 | 0.052 | -3 | 0.388 |
ERK1 |
0.696 | -0.012 | 1 | 0.569 |
PKCZ |
0.696 | -0.089 | 2 | 0.749 |
PRP4 |
0.696 | -0.042 | -3 | 0.430 |
MEKK1 |
0.695 | -0.111 | 1 | 0.809 |
DAPK3 |
0.695 | -0.010 | -3 | 0.493 |
PERK |
0.695 | -0.076 | -2 | 0.812 |
PAK2 |
0.695 | -0.081 | -2 | 0.696 |
CHK2 |
0.695 | 0.021 | -3 | 0.370 |
IRE2 |
0.694 | -0.130 | 2 | 0.706 |
HIPK1 |
0.694 | -0.031 | 1 | 0.670 |
CDK13 |
0.694 | -0.039 | 1 | 0.596 |
P38G |
0.694 | -0.010 | 1 | 0.504 |
PLK4 |
0.693 | -0.079 | 2 | 0.584 |
CDK17 |
0.693 | -0.009 | 1 | 0.504 |
ERK2 |
0.693 | -0.025 | 1 | 0.613 |
P70S6K |
0.693 | -0.065 | -3 | 0.393 |
CHAK1 |
0.692 | -0.145 | 2 | 0.721 |
SSTK |
0.692 | -0.019 | 4 | 0.826 |
PAK6 |
0.692 | -0.038 | -2 | 0.624 |
NEK2 |
0.691 | -0.134 | 2 | 0.783 |
WNK4 |
0.691 | -0.077 | -2 | 0.802 |
AKT1 |
0.691 | -0.042 | -3 | 0.419 |
NEK11 |
0.691 | -0.024 | 1 | 0.805 |
MST2 |
0.691 | -0.002 | 1 | 0.832 |
DCAMKL2 |
0.691 | -0.028 | -3 | 0.477 |
DYRK4 |
0.691 | -0.017 | 1 | 0.583 |
HRI |
0.690 | -0.109 | -2 | 0.794 |
JNK1 |
0.690 | 0.003 | 1 | 0.568 |
TAK1 |
0.690 | 0.070 | 1 | 0.857 |
NEK5 |
0.690 | -0.108 | 1 | 0.809 |
SBK |
0.689 | 0.010 | -3 | 0.330 |
BUB1 |
0.688 | 0.186 | -5 | 0.634 |
TTBK1 |
0.688 | -0.049 | 2 | 0.590 |
SNRK |
0.687 | -0.156 | 2 | 0.636 |
DYRK1A |
0.686 | -0.052 | 1 | 0.686 |
HPK1 |
0.686 | 0.023 | 1 | 0.817 |
SGK1 |
0.686 | -0.033 | -3 | 0.366 |
P38D |
0.686 | 0.002 | 1 | 0.506 |
CDK12 |
0.686 | -0.041 | 1 | 0.571 |
CDK14 |
0.686 | -0.012 | 1 | 0.596 |
CDK16 |
0.686 | -0.002 | 1 | 0.518 |
EEF2K |
0.685 | -0.022 | 3 | 0.512 |
MPSK1 |
0.684 | -0.038 | 1 | 0.731 |
CDK10 |
0.684 | -0.018 | 1 | 0.579 |
PINK1 |
0.684 | -0.146 | 1 | 0.780 |
NEK8 |
0.683 | -0.096 | 2 | 0.784 |
CDK9 |
0.683 | -0.063 | 1 | 0.600 |
AKT3 |
0.683 | -0.042 | -3 | 0.377 |
DYRK1B |
0.683 | -0.048 | 1 | 0.608 |
PHKG2 |
0.682 | -0.081 | -3 | 0.465 |
MINK |
0.682 | -0.025 | 1 | 0.808 |
CAMKK1 |
0.682 | -0.110 | -2 | 0.718 |
PKCE |
0.681 | -0.045 | 2 | 0.685 |
PKCT |
0.681 | -0.093 | 2 | 0.700 |
DYRK3 |
0.681 | -0.046 | 1 | 0.678 |
MRCKA |
0.680 | -0.039 | -3 | 0.448 |
TAO2 |
0.679 | -0.106 | 2 | 0.815 |
PKCI |
0.679 | -0.064 | 2 | 0.715 |
PKN1 |
0.679 | -0.032 | -3 | 0.403 |
HIPK3 |
0.679 | -0.059 | 1 | 0.668 |
KHS2 |
0.679 | -0.009 | 1 | 0.817 |
IRAK4 |
0.678 | -0.147 | 1 | 0.765 |
PAK5 |
0.678 | -0.061 | -2 | 0.567 |
MST1 |
0.677 | -0.041 | 1 | 0.807 |
CAMKK2 |
0.677 | -0.113 | -2 | 0.704 |
PDK1 |
0.676 | -0.097 | 1 | 0.779 |
TNIK |
0.676 | -0.075 | 3 | 0.513 |
PAK4 |
0.676 | -0.053 | -2 | 0.579 |
IRAK1 |
0.675 | -0.156 | -1 | 0.710 |
TTK |
0.675 | 0.010 | -2 | 0.807 |
MAK |
0.675 | -0.019 | -2 | 0.681 |
LKB1 |
0.675 | -0.133 | -3 | 0.472 |
MAP3K15 |
0.675 | -0.086 | 1 | 0.772 |
HGK |
0.674 | -0.082 | 3 | 0.518 |
MRCKB |
0.674 | -0.057 | -3 | 0.433 |
SLK |
0.674 | -0.065 | -2 | 0.651 |
KHS1 |
0.673 | -0.048 | 1 | 0.798 |
DMPK1 |
0.673 | -0.018 | -3 | 0.460 |
YANK2 |
0.672 | 0.108 | 2 | 0.401 |
ROCK2 |
0.672 | -0.067 | -3 | 0.477 |
LRRK2 |
0.671 | -0.101 | 2 | 0.816 |
PDHK4_TYR |
0.671 | 0.150 | 2 | 0.864 |
OSR1 |
0.671 | -0.036 | 2 | 0.782 |
PDHK3_TYR |
0.671 | 0.128 | 4 | 0.898 |
MEKK6 |
0.671 | -0.119 | 1 | 0.801 |
ERK7 |
0.671 | -0.027 | 2 | 0.541 |
CRIK |
0.670 | -0.027 | -3 | 0.412 |
ALPHAK3 |
0.670 | 0.049 | -1 | 0.745 |
NEK4 |
0.670 | -0.142 | 1 | 0.783 |
VRK1 |
0.669 | -0.131 | 2 | 0.800 |
STK33 |
0.669 | -0.077 | 2 | 0.581 |
MAP2K6_TYR |
0.669 | 0.128 | -1 | 0.870 |
RIPK2 |
0.667 | -0.129 | 1 | 0.747 |
BMPR2_TYR |
0.667 | 0.094 | -1 | 0.863 |
PDHK1_TYR |
0.667 | 0.128 | -1 | 0.876 |
NEK1 |
0.665 | -0.138 | 1 | 0.780 |
LOK |
0.664 | -0.120 | -2 | 0.689 |
MAP2K4_TYR |
0.663 | 0.053 | -1 | 0.859 |
CDK6 |
0.663 | -0.056 | 1 | 0.567 |
YSK1 |
0.662 | -0.100 | 2 | 0.791 |
MOK |
0.661 | -0.051 | 1 | 0.678 |
PKG1 |
0.659 | -0.071 | -2 | 0.533 |
ROCK1 |
0.659 | -0.072 | -3 | 0.447 |
CDK4 |
0.658 | -0.063 | 1 | 0.557 |
PBK |
0.657 | -0.081 | 1 | 0.705 |
MEK2 |
0.657 | -0.192 | 2 | 0.776 |
TESK1_TYR |
0.655 | -0.091 | 3 | 0.528 |
MAP2K7_TYR |
0.654 | -0.100 | 2 | 0.831 |
TXK |
0.653 | 0.017 | 1 | 0.876 |
SYK |
0.652 | 0.125 | -1 | 0.781 |
FGR |
0.651 | 0.022 | 1 | 0.834 |
INSRR |
0.651 | -0.030 | 3 | 0.424 |
PKMYT1_TYR |
0.651 | -0.112 | 3 | 0.506 |
PINK1_TYR |
0.649 | -0.134 | 1 | 0.821 |
MYO3A |
0.649 | -0.087 | 1 | 0.780 |
HASPIN |
0.649 | -0.064 | -1 | 0.641 |
BIKE |
0.648 | -0.032 | 1 | 0.652 |
FER |
0.647 | -0.024 | 1 | 0.880 |
EPHA6 |
0.647 | -0.058 | -1 | 0.851 |
ASK1 |
0.647 | -0.126 | 1 | 0.759 |
EPHA4 |
0.647 | 0.004 | 2 | 0.752 |
EPHB4 |
0.647 | -0.057 | -1 | 0.831 |
MYO3B |
0.646 | -0.103 | 2 | 0.789 |
NEK3 |
0.645 | -0.178 | 1 | 0.744 |
TAO1 |
0.645 | -0.123 | 1 | 0.727 |
STLK3 |
0.644 | -0.100 | 1 | 0.765 |
FLT1 |
0.643 | 0.015 | -1 | 0.837 |
PTK2 |
0.643 | 0.077 | -1 | 0.790 |
RET |
0.642 | -0.144 | 1 | 0.798 |
EPHB1 |
0.642 | -0.038 | 1 | 0.877 |
FYN |
0.642 | 0.021 | -1 | 0.764 |
SRMS |
0.642 | -0.041 | 1 | 0.883 |
CSF1R |
0.641 | -0.110 | 3 | 0.434 |
DDR1 |
0.641 | -0.127 | 4 | 0.841 |
MST1R |
0.641 | -0.129 | 3 | 0.452 |
YES1 |
0.641 | -0.081 | -1 | 0.793 |
KIT |
0.640 | -0.055 | 3 | 0.446 |
ABL2 |
0.640 | -0.080 | -1 | 0.779 |
EPHB2 |
0.640 | -0.036 | -1 | 0.813 |
JAK3 |
0.639 | -0.092 | 1 | 0.784 |
MET |
0.639 | -0.044 | 3 | 0.434 |
TYK2 |
0.639 | -0.161 | 1 | 0.798 |
ROS1 |
0.639 | -0.163 | 3 | 0.423 |
BLK |
0.638 | -0.048 | -1 | 0.795 |
LIMK2_TYR |
0.638 | -0.172 | -3 | 0.506 |
HCK |
0.638 | -0.064 | -1 | 0.787 |
TYRO3 |
0.638 | -0.162 | 3 | 0.443 |
ABL1 |
0.637 | -0.057 | -1 | 0.766 |
EPHB3 |
0.637 | -0.065 | -1 | 0.819 |
ITK |
0.637 | -0.086 | -1 | 0.758 |
FGFR2 |
0.637 | -0.077 | 3 | 0.475 |
LCK |
0.637 | -0.061 | -1 | 0.789 |
BMX |
0.636 | -0.029 | -1 | 0.679 |
KDR |
0.636 | -0.088 | 3 | 0.422 |
JAK2 |
0.636 | -0.154 | 1 | 0.794 |
LIMK1_TYR |
0.636 | -0.215 | 2 | 0.814 |
ERBB2 |
0.634 | -0.028 | 1 | 0.777 |
FLT3 |
0.634 | -0.105 | 3 | 0.438 |
FGFR3 |
0.634 | -0.053 | 3 | 0.454 |
EPHA5 |
0.634 | -0.013 | 2 | 0.737 |
EPHA7 |
0.633 | -0.046 | 2 | 0.748 |
AAK1 |
0.633 | -0.009 | 1 | 0.534 |
EPHA3 |
0.633 | -0.034 | 2 | 0.723 |
TEC |
0.633 | -0.070 | -1 | 0.681 |
ERBB4 |
0.631 | 0.035 | 1 | 0.731 |
NTRK1 |
0.630 | -0.103 | -1 | 0.822 |
PDGFRB |
0.630 | -0.157 | 3 | 0.451 |
MERTK |
0.630 | -0.084 | 3 | 0.421 |
DDR2 |
0.629 | -0.079 | 3 | 0.430 |
EGFR |
0.629 | -0.007 | 1 | 0.693 |
INSR |
0.629 | -0.089 | 3 | 0.403 |
EPHA8 |
0.629 | -0.038 | -1 | 0.794 |
TNK2 |
0.629 | -0.141 | 3 | 0.426 |
FRK |
0.628 | -0.057 | -1 | 0.806 |
LYN |
0.628 | -0.066 | 3 | 0.399 |
TEK |
0.628 | -0.151 | 3 | 0.412 |
SRC |
0.627 | -0.036 | -1 | 0.751 |
WEE1_TYR |
0.627 | -0.049 | -1 | 0.716 |
FGFR1 |
0.626 | -0.140 | 3 | 0.424 |
MATK |
0.626 | -0.049 | -1 | 0.712 |
BTK |
0.626 | -0.134 | -1 | 0.724 |
ALK |
0.625 | -0.132 | 3 | 0.395 |
FLT4 |
0.625 | -0.098 | 3 | 0.433 |
FGFR4 |
0.625 | -0.018 | -1 | 0.751 |
NTRK3 |
0.625 | -0.083 | -1 | 0.779 |
JAK1 |
0.624 | -0.120 | 1 | 0.750 |
TNNI3K_TYR |
0.624 | -0.103 | 1 | 0.783 |
NEK10_TYR |
0.623 | -0.128 | 1 | 0.686 |
LTK |
0.623 | -0.124 | 3 | 0.413 |
AXL |
0.623 | -0.145 | 3 | 0.429 |
NTRK2 |
0.623 | -0.138 | 3 | 0.422 |
PTK2B |
0.623 | -0.055 | -1 | 0.717 |
EPHA2 |
0.622 | -0.036 | -1 | 0.775 |
IGF1R |
0.621 | -0.060 | 3 | 0.373 |
ZAP70 |
0.620 | 0.040 | -1 | 0.695 |
PDGFRA |
0.620 | -0.180 | 3 | 0.449 |
CSK |
0.620 | -0.064 | 2 | 0.749 |
EPHA1 |
0.619 | -0.126 | 3 | 0.409 |
PTK6 |
0.619 | -0.128 | -1 | 0.676 |
TNK1 |
0.616 | -0.193 | 3 | 0.430 |
FES |
0.608 | -0.041 | -1 | 0.650 |
MUSK |
0.601 | -0.111 | 1 | 0.675 |