Motif 493 (n=142)

Position-wise Probabilities
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uniprot genes site source protein function
A6NCI8 C2orf78 S819 ochoa Uncharacterized protein C2orf78 None
H7C1W4 None T341 ochoa Uncharacterized protein None
O00560 SDCBP S33 ochoa Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}.
O14492 SH2B2 S115 ochoa SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.
O14544 SOCS6 S105 ochoa Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.
O15042 U2SURP S24 ochoa U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) None
O15119 TBX3 S703 ochoa T-box transcription factor TBX3 (T-box protein 3) Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}.
O15164 TRIM24 S768 ochoa|psp Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}.
O15381 NVL T146 ochoa Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}.
O43182 ARHGAP6 S928 ochoa Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.
O43597 SPRY2 S139 ochoa Protein sprouty homolog 2 (Spry-2) Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}.
O60292 SIPA1L3 S1383 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60307 MAST3 Y708 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60307 MAST3 S1099 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60508 CDC40 S43 ochoa Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}.
O75152 ZC3H11A S735 ochoa Zinc finger CCCH domain-containing protein 11A Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.
O75179 ANKRD17 S2451 ochoa Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
O95487 SEC24B S322 ochoa Protein transport protein Sec24B (SEC24-related protein B) Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.
O95936 EOMES S648 ochoa Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}.
P08648 ITGA5 S124 ochoa Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.
P08727 KRT19 S55 ochoa Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19) Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.
P16070 CD44 S180 ochoa CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}.
P16383 GCFC2 S117 ochoa Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}.
P21333 FLNA S1921 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P25054 APC S2765 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P29375 KDM5A S1327 ochoa Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}.
P29590 PML S580 ochoa Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}.
P35408 PTGER4 S374 psp Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
P35414 APLNR S345 ochoa Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11090199, PubMed:22810587, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G-protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy (PubMed:22810587, PubMed:38428423). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587, PubMed:38428423). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:22810587, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936, ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199). {ECO:0000269|PubMed:11090199}.
P41212 ETV6 Y27 ochoa|psp Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.
P42166 TMPO S293 ochoa Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P42694 HELZ S1738 ochoa Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
P42695 NCAPD3 S517 ochoa Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.
P50616 TOB1 S148 ochoa Protein Tob1 (Transducer of erbB-2 1) Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}.
P50851 LRBA S1785 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
P51608 MECP2 S357 ochoa Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.
P52594 AGFG1 S147 ochoa Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}.
P52594 AGFG1 S150 ochoa Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}.
P52701 MSH6 S328 ochoa DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.
P54296 MYOM2 S59 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54646 PRKAA2 S481 ochoa 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
P55197 MLLT10 S364 ochoa Protein AF-10 (ALL1-fused gene from chromosome 10 protein) Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.
P57768 SNX16 S66 ochoa Sorting nexin-16 May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}.
P78312 FAM193A S266 ochoa Protein FAM193A (Protein IT14) None
P78362 SRPK2 S494 ochoa|psp SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}.
P85299 PRR5 T336 ochoa Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}.
Q07157 TJP1 S1397 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q12948 FOXC1 S269 ochoa Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}.
Q13263 TRIM28 S437 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13905 RAPGEF1 S311 ochoa Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.
Q14004 CDK13 S1343 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14157 UBAP2L S605 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14315 FLNC S2624 ochoa|psp Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q15032 R3HDM1 S394 ochoa R3H domain-containing protein 1 None
Q155Q3 DIXDC1 S590 ochoa Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}.
Q15648 MED1 S1138 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15714 TSC22D1 T265 ochoa TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}.
Q15714 TSC22D1 S268 ochoa TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}.
Q16625 OCLN S341 ochoa Occludin May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}.
Q2M2I3 FAM83E S384 ochoa Protein FAM83E May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}.
Q3L8U1 CHD9 S2009 ochoa Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Q53HC9 EIPR1 S304 ochoa EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). {ECO:0000250|UniProtKB:Q5PPK9, ECO:0000269|PubMed:27440922}.
Q5FWE3 PRRT3 S925 ochoa Proline-rich transmembrane protein 3 None
Q5SNT2 TMEM201 S441 ochoa Transmembrane protein 201 (Spindle-associated membrane protein 1) Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
Q5T481 RBM20 S657 ochoa RNA-binding protein 20 (RNA-binding motif protein 20) RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}.
Q5T5P2 KIAA1217 S1702 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5T5Y3 CAMSAP1 S1398 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5T8I3 EEIG2 S224 ochoa EEIG family member 2 (EEIG2) None
Q5U5Q3 MEX3C S537 ochoa RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.
Q5VT52 RPRD2 S1134 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q68EM7 ARHGAP17 S703 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6DN14 MCTP1 S165 ochoa Multiple C2 and transmembrane domain-containing protein 1 Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}.
Q6KC79 NIPBL S150 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6P0Q8 MAST2 S1295 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6R327 RICTOR S1231 ochoa Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}.
Q6ZVM7 TOM1L2 S191 ochoa TOM1-like protein 2 (Target of Myb-like protein 2) Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}.
Q70E73 RAPH1 S538 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q7Z3K3 POGZ S254 ochoa Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.
Q7Z3U7 MON2 S646 ochoa Protein MON2 homolog (Protein SF21) Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.
Q7Z591 AKNA S534 ochoa Microtubule organization protein AKNA (AT-hook-containing transcription factor) Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
Q7Z5K2 WAPL S156 ochoa Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.
Q7Z6B7 SRGAP1 S1029 ochoa SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Q7Z6I6 ARHGAP30 S1064 ochoa Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}.
Q86SQ0 PHLDB2 S563 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q8IX03 WWC1 S435 ochoa Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}.
Q8IXZ2 ZC3H3 S877 ochoa Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}.
Q8IXZ2 ZC3H3 S878 ochoa Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}.
Q8IY26 PLPP6 S19 ochoa Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354). {ECO:0000269|PubMed:16464866, ECO:0000269|PubMed:18930839, ECO:0000269|PubMed:19220020, ECO:0000269|PubMed:20110354, ECO:0000269|PubMed:23568778}.
Q8NF91 SYNE1 S8724 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8TBP0 TBC1D16 S257 ochoa TBC1 domain family member 16 May act as a GTPase-activating protein for Rab family protein(s).
Q8TDW5 SYTL5 T260 ochoa Synaptotagmin-like protein 5 May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
Q8WUI4 HDAC7 S207 ochoa Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}.
Q92574 TSC1 S1039 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q92574 TSC1 S1040 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q92793 CREBBP S90 ochoa CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}.
Q92841 DDX17 S672 ochoa Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}.
Q92994 BRF1 S433 ochoa Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.
Q93075 TATDN2 T398 ochoa 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}.
Q96D71 REPS1 S219 ochoa RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96K76 USP47 S965 ochoa Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.
Q96L34 MARK4 S45 ochoa MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}.
Q96L34 MARK4 S543 ochoa MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}.
Q96QB1 DLC1 S596 ochoa Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}.
Q96RU2 USP28 S518 ochoa Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}.
Q96SD1 DCLRE1C S645 psp Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}.
Q96TA1 NIBAN2 S725 ochoa Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}.
Q99081 TCF12 S301 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q9BRK4 LZTS2 S224 ochoa|psp Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
Q9BW04 SARG S36 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BW04 SARG S310 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BWT7 CARD10 S569 ochoa Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}.
Q9BXB5 OSBPL10 S26 ochoa Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}.
Q9BY89 KIAA1671 S1574 ochoa Uncharacterized protein KIAA1671 None
Q9BZ71 PITPNM3 S295 ochoa Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}.
Q9BZB8 CPEB1 S178 ochoa Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1) Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). {ECO:0000250|UniProtKB:P70166, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195}.
Q9C0B9 ZCCHC2 S764 ochoa Zinc finger CCHC domain-containing protein 2 None
Q9H1A4 ANAPC1 S334 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H3Q1 CDC42EP4 S309 ochoa Cdc42 effector protein 4 (Binder of Rho GTPases 4) Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Q9H7N4 SCAF1 S825 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9HAW4 CLSPN S830 ochoa Claspin (hClaspin) Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
Q9HCD6 TANC2 S1722 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9HCE3 ZNF532 S347 ochoa Zinc finger protein 532 May be involved in transcriptional regulation.
Q9NTI5 PDS5B S1159 ochoa Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}.
Q9NYL2 MAP3K20 S687 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9P0J7 KCMF1 S184 ochoa E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}.
Q9P265 DIP2B S183 ochoa Disco-interacting protein 2 homolog B (DIP2 homolog B) Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}.
Q9P266 JCAD S626 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9P270 SLAIN2 S431 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9P286 PAK5 S223 ochoa Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.
Q9UDT6 CLIP2 S27 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UHB7 AFF4 S176 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UKF7 PITPNC1 S270 ochoa Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}.
Q9ULH1 ASAP1 S817 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9ULJ7 ANKRD50 S1135 ochoa Ankyrin repeat domain-containing protein 50 Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Q9ULK2 ATXN7L1 S840 ochoa Ataxin-7-like protein 1 (Ataxin-7-like protein 4) None
Q9UMS6 SYNPO2 S1061 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UPW6 SATB2 S450 ochoa DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.
Q9Y250 LZTS1 S178 ochoa Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.
Q9Y2H2 INPP5F S907 ochoa Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}.
Q9Y3Q8 TSC22D4 S187 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y4B4 RAD54L2 S1152 ochoa Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}.
Q9Y4G8 RAPGEF2 S1156 ochoa Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.
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reactome_id name p -log10_p
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 2.614421e-07 6.583
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 1.543306e-06 5.812
R-HSA-9022534 Loss of MECP2 binding ability to 5hmC-DNA 1.960871e-04 3.708
R-HSA-2470946 Cohesin Loading onto Chromatin 1.519089e-04 3.818
R-HSA-9022692 Regulation of MECP2 expression and activity 6.855456e-04 3.164
R-HSA-68884 Mitotic Telophase/Cytokinesis 4.942726e-04 3.306
R-HSA-111465 Apoptotic cleavage of cellular proteins 6.226765e-04 3.206
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 1.201645e-03 2.920
R-HSA-9022927 MECP2 regulates transcription of genes involved in GABA signaling 1.719064e-03 2.765
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 1.701661e-03 2.769
R-HSA-73857 RNA Polymerase II Transcription 1.708322e-03 2.767
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 2.324563e-03 2.634
R-HSA-75153 Apoptotic execution phase 2.245033e-03 2.649
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 3.016360e-03 2.521
R-HSA-350054 Notch-HLH transcription pathway 2.924306e-03 2.534
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 3.016360e-03 2.521
R-HSA-9022707 MECP2 regulates transcription factors 4.651852e-03 2.332
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 4.651852e-03 2.332
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 5.864916e-03 2.232
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 5.592113e-03 2.252
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 5.864916e-03 2.232
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 7.709273e-03 2.113
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 7.709273e-03 2.113
R-HSA-9924644 Developmental Lineages of the Mammary Gland 8.864946e-03 2.052
R-HSA-8941332 RUNX2 regulates genes involved in cell migration 8.882890e-03 2.051
R-HSA-74160 Gene expression (Transcription) 8.017660e-03 2.096
R-HSA-212436 Generic Transcription Pathway 7.443667e-03 2.128
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 8.356193e-03 2.078
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 9.948629e-03 2.002
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 1.145218e-02 1.941
R-HSA-9005895 Pervasive developmental disorders 1.145218e-02 1.941
R-HSA-9697154 Disorders of Nervous System Development 1.145218e-02 1.941
R-HSA-428540 Activation of RAC1 1.013105e-02 1.994
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 1.138338e-02 1.944
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.175644e-02 1.930
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 1.274878e-02 1.895
R-HSA-9816359 Maternal to zygotic transition (MZT) 1.267586e-02 1.897
R-HSA-8878171 Transcriptional regulation by RUNX1 1.238537e-02 1.907
R-HSA-9707564 Cytoprotection by HMOX1 1.365145e-02 1.865
R-HSA-1433559 Regulation of KIT signaling 1.430711e-02 1.844
R-HSA-446353 Cell-extracellular matrix interactions 1.583788e-02 1.800
R-HSA-8986944 Transcriptional Regulation by MECP2 1.859570e-02 1.731
R-HSA-9675151 Disorders of Developmental Biology 1.909857e-02 1.719
R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 1.979889e-02 1.703
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 2.001284e-02 1.699
R-HSA-2028269 Signaling by Hippo 2.082560e-02 1.681
R-HSA-9754189 Germ layer formation at gastrulation 2.446589e-02 1.611
R-HSA-9012852 Signaling by NOTCH3 2.588628e-02 1.587
R-HSA-5357801 Programmed Cell Death 2.636950e-02 1.579
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 3.245301e-02 1.489
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 3.316606e-02 1.479
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3.141148e-02 1.503
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3.141148e-02 1.503
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3.141148e-02 1.503
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3.141148e-02 1.503
R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 2.955175e-02 1.529
R-HSA-2644603 Signaling by NOTCH1 in Cancer 3.141148e-02 1.503
R-HSA-9758941 Gastrulation 2.698861e-02 1.569
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 3.458922e-02 1.461
R-HSA-9707616 Heme signaling 3.378100e-02 1.471
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 3.499969e-02 1.456
R-HSA-109581 Apoptosis 3.549020e-02 1.450
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 4.131201e-02 1.384
R-HSA-1592230 Mitochondrial biogenesis 4.337734e-02 1.363
R-HSA-389357 CD28 dependent PI3K/Akt signaling 4.365354e-02 1.360
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 5.096314e-02 1.293
R-HSA-111446 Activation of BIM and translocation to mitochondria 4.876910e-02 1.312
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 4.848027e-02 1.314
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 4.876910e-02 1.312
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.390047e-02 1.358
R-HSA-1980143 Signaling by NOTCH1 5.285861e-02 1.277
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 5.823547e-02 1.235
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 6.402729e-02 1.194
R-HSA-191650 Regulation of gap junction activity 5.823547e-02 1.235
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 5.823547e-02 1.235
R-HSA-165181 Inhibition of TSC complex formation by PKB 5.823547e-02 1.235
R-HSA-1852241 Organelle biogenesis and maintenance 5.582509e-02 1.253
R-HSA-3700989 Transcriptional Regulation by TP53 5.641618e-02 1.249
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 6.069225e-02 1.217
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 6.760821e-02 1.170
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 6.760821e-02 1.170
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 1.130994e-01 0.947
R-HSA-4839744 Signaling by APC mutants 1.306720e-01 0.884
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.306720e-01 0.884
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.306720e-01 0.884
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.306720e-01 0.884
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.393281e-01 0.856
R-HSA-5339716 Signaling by GSK3beta mutants 1.393281e-01 0.856
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.478986e-01 0.830
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.478986e-01 0.830
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.478986e-01 0.830
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.478986e-01 0.830
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.478986e-01 0.830
R-HSA-1295596 Spry regulation of FGF signaling 1.731043e-01 0.762
R-HSA-9027284 Erythropoietin activates RAS 1.731043e-01 0.762
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.731043e-01 0.762
R-HSA-196299 Beta-catenin phosphorylation cascade 1.731043e-01 0.762
R-HSA-176412 Phosphorylation of the APC/C 1.813405e-01 0.742
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 1.813405e-01 0.742
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 2.134778e-01 0.671
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 2.290730e-01 0.640
R-HSA-72187 mRNA 3'-end processing 1.216178e-01 0.915
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.884404e-01 0.540
R-HSA-1989781 PPARA activates gene expression 2.502395e-01 0.602
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 1.563842e-01 0.806
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 2.555756e-01 0.592
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 2.604818e-01 0.584
R-HSA-5620916 VxPx cargo-targeting to cilium 2.213142e-01 0.655
R-HSA-5654732 Negative regulation of FGFR3 signaling 2.884404e-01 0.540
R-HSA-5654733 Negative regulation of FGFR4 signaling 2.955343e-01 0.529
R-HSA-5654727 Negative regulation of FGFR2 signaling 3.366459e-01 0.473
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.740388e-01 0.562
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 1.130994e-01 0.947
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 1.894951e-01 0.722
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 2.367551e-01 0.626
R-HSA-2467813 Separation of Sister Chromatids 1.107918e-01 0.955
R-HSA-5654726 Negative regulation of FGFR1 signaling 3.232141e-01 0.491
R-HSA-8941856 RUNX3 regulates NOTCH signaling 1.478986e-01 0.830
R-HSA-69618 Mitotic Spindle Checkpoint 3.046928e-01 0.516
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1.975690e-01 0.704
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1.975690e-01 0.704
R-HSA-9823730 Formation of definitive endoderm 2.213142e-01 0.655
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.538435e-01 0.813
R-HSA-9703465 Signaling by FLT3 fusion proteins 2.740388e-01 0.562
R-HSA-9613354 Lipophagy 1.130994e-01 0.947
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 2.443610e-01 0.612
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1.393281e-01 0.856
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 3.299634e-01 0.482
R-HSA-4791275 Signaling by WNT in cancer 3.163972e-01 0.500
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 9.296741e-02 1.032
R-HSA-428543 Inactivation of CDC42 and RAC1 1.130994e-01 0.947
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1.219294e-01 0.914
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 1.393281e-01 0.856
R-HSA-4839748 Signaling by AMER1 mutants 1.393281e-01 0.856
R-HSA-4839735 Signaling by AXIN mutants 1.393281e-01 0.856
R-HSA-1566977 Fibronectin matrix formation 1.894951e-01 0.722
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.894951e-01 0.722
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 1.802180e-01 0.744
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.945786e-01 0.711
R-HSA-76046 RNA Polymerase III Transcription Initiation 3.025580e-01 0.519
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1.478986e-01 0.830
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 1.041812e-01 0.982
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 2.055630e-01 0.687
R-HSA-5358508 Mismatch Repair 2.055630e-01 0.687
R-HSA-9734767 Developmental Cell Lineages 3.142816e-01 0.503
R-HSA-8875555 MET activates RAP1 and RAC1 1.219294e-01 0.914
R-HSA-9761174 Formation of intermediate mesoderm 1.219294e-01 0.914
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 2.134778e-01 0.671
R-HSA-1483226 Synthesis of PI 1.306720e-01 0.884
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.894951e-01 0.722
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 3.025580e-01 0.519
R-HSA-9006335 Signaling by Erythropoietin 2.955343e-01 0.529
R-HSA-9711123 Cellular response to chemical stress 1.632681e-01 0.787
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3.366459e-01 0.473
R-HSA-68886 M Phase 1.110921e-01 0.954
R-HSA-9843745 Adipogenesis 1.829854e-01 0.738
R-HSA-9818749 Regulation of NFE2L2 gene expression 8.607648e-02 1.065
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.812754e-01 0.551
R-HSA-9909396 Circadian clock 1.854785e-01 0.732
R-HSA-918233 TRAF3-dependent IRF activation pathway 1.894951e-01 0.722
R-HSA-8948747 Regulation of PTEN localization 9.517383e-02 1.021
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 1.130994e-01 0.947
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 1.813405e-01 0.742
R-HSA-429947 Deadenylation of mRNA 2.593476e-01 0.586
R-HSA-9839394 TGFBR3 expression 2.667298e-01 0.574
R-HSA-73856 RNA Polymerase II Transcription Termination 1.520605e-01 0.818
R-HSA-9855142 Cellular responses to mechanical stimuli 1.330671e-01 0.876
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 1.873786e-01 0.727
R-HSA-165159 MTOR signalling 8.993932e-02 1.046
R-HSA-1839124 FGFR1 mutant receptor activation 3.232141e-01 0.491
R-HSA-176187 Activation of ATR in response to replication stress 3.232141e-01 0.491
R-HSA-68882 Mitotic Anaphase 8.938417e-02 1.049
R-HSA-9860931 Response of endothelial cells to shear stress 1.091699e-01 0.962
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 3.232141e-01 0.491
R-HSA-2555396 Mitotic Metaphase and Anaphase 9.060057e-02 1.043
R-HSA-1632852 Macroautophagy 2.108738e-01 0.676
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 6.760821e-02 1.170
R-HSA-9614657 FOXO-mediated transcription of cell death genes 2.055630e-01 0.687
R-HSA-9675126 Diseases of mitotic cell cycle 3.163972e-01 0.500
R-HSA-9930044 Nuclear RNA decay 3.232141e-01 0.491
R-HSA-2142845 Hyaluronan metabolism 3.366459e-01 0.473
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.593476e-01 0.586
R-HSA-182971 EGFR downregulation 3.095120e-01 0.509
R-HSA-9612973 Autophagy 2.529054e-01 0.597
R-HSA-1640170 Cell Cycle 3.069662e-01 0.513
R-HSA-9706369 Negative regulation of FLT3 1.813405e-01 0.742
R-HSA-4419969 Depolymerization of the Nuclear Lamina 2.055630e-01 0.687
R-HSA-2160916 Hyaluronan degradation 2.667298e-01 0.574
R-HSA-9833109 Evasion by RSV of host interferon responses 3.095120e-01 0.509
R-HSA-5694530 Cargo concentration in the ER 3.095120e-01 0.509
R-HSA-170968 Frs2-mediated activation 1.563842e-01 0.806
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.273524e-01 0.643
R-HSA-5628897 TP53 Regulates Metabolic Genes 1.375951e-01 0.861
R-HSA-447043 Neurofascin interactions 8.607648e-02 1.065
R-HSA-912631 Regulation of signaling by CBL 2.134778e-01 0.671
R-HSA-8854214 TBC/RABGAPs 9.298388e-02 1.032
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.367551e-01 0.626
R-HSA-525793 Myogenesis 2.740388e-01 0.562
R-HSA-9663891 Selective autophagy 2.531052e-01 0.597
R-HSA-157118 Signaling by NOTCH 1.208889e-01 0.918
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 3.193474e-01 0.496
R-HSA-110357 Displacement of DNA glycosylase by APEX1 9.517383e-02 1.021
R-HSA-1482801 Acyl chain remodelling of PS 2.667298e-01 0.574
R-HSA-8953854 Metabolism of RNA 1.505193e-01 0.822
R-HSA-9819196 Zygotic genome activation (ZGA) 2.290730e-01 0.640
R-HSA-3214842 HDMs demethylate histones 2.667298e-01 0.574
R-HSA-430116 GP1b-IX-V activation signalling 1.130994e-01 0.947
R-HSA-391908 Prostanoid ligand receptors 1.306720e-01 0.884
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 2.290730e-01 0.640
R-HSA-9833110 RSV-host interactions 3.230003e-01 0.491
R-HSA-169893 Prolonged ERK activation events 1.813405e-01 0.742
R-HSA-1433557 Signaling by SCF-KIT 9.298388e-02 1.032
R-HSA-200425 Carnitine shuttle 2.518916e-01 0.599
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 3.366459e-01 0.473
R-HSA-1266738 Developmental Biology 1.773223e-01 0.751
R-HSA-3928664 Ephrin signaling 2.055630e-01 0.687
R-HSA-445144 Signal transduction by L1 2.213142e-01 0.655
R-HSA-216083 Integrin cell surface interactions 2.127225e-01 0.672
R-HSA-69242 S Phase 2.317099e-01 0.635
R-HSA-877300 Interferon gamma signaling 1.028110e-01 0.988
R-HSA-9671555 Signaling by PDGFR in disease 2.367551e-01 0.626
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.812754e-01 0.551
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 2.667298e-01 0.574
R-HSA-9733709 Cardiogenesis 3.232141e-01 0.491
R-HSA-9694631 Maturation of nucleoprotein 2.134778e-01 0.671
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 2.443610e-01 0.612
R-HSA-9830674 Formation of the ureteric bud 2.518916e-01 0.599
R-HSA-8983711 OAS antiviral response 1.478986e-01 0.830
R-HSA-5218920 VEGFR2 mediated vascular permeability 8.394287e-02 1.076
R-HSA-391903 Eicosanoid ligand-binding receptors 2.213142e-01 0.655
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 1.086345e-01 0.964
R-HSA-186763 Downstream signal transduction 3.095120e-01 0.509
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 7.519377e-02 1.124
R-HSA-9827857 Specification of primordial germ cells 1.975690e-01 0.704
R-HSA-389356 Co-stimulation by CD28 1.086345e-01 0.964
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 2.740388e-01 0.562
R-HSA-114452 Activation of BH3-only proteins 3.025580e-01 0.519
R-HSA-5633007 Regulation of TP53 Activity 1.043852e-01 0.981
R-HSA-162582 Signal Transduction 3.362586e-01 0.473
R-HSA-5689880 Ub-specific processing proteases 3.014511e-01 0.521
R-HSA-5675482 Regulation of necroptotic cell death 3.232141e-01 0.491
R-HSA-388841 Regulation of T cell activation by CD28 family 2.985937e-01 0.525
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 2.884404e-01 0.540
R-HSA-5688426 Deubiquitination 2.963604e-01 0.528
R-HSA-8878166 Transcriptional regulation by RUNX2 1.491399e-01 0.826
R-HSA-6804757 Regulation of TP53 Degradation 6.953593e-02 1.158
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 2.200269e-01 0.658
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 3.339290e-01 0.476
R-HSA-6806003 Regulation of TP53 Expression and Degradation 7.807613e-02 1.107
R-HSA-9768919 NPAS4 regulates expression of target genes 3.366459e-01 0.473
R-HSA-9700206 Signaling by ALK in cancer 3.339290e-01 0.476
R-HSA-8957322 Metabolism of steroids 2.620103e-01 0.582
R-HSA-381038 XBP1(S) activates chaperone genes 2.457342e-01 0.610
R-HSA-381070 IRE1alpha activates chaperones 2.678608e-01 0.572
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 3.432621e-01 0.464
R-HSA-187687 Signalling to ERKs 3.432621e-01 0.464
R-HSA-6798695 Neutrophil degranulation 3.447453e-01 0.463
R-HSA-5617833 Cilium Assembly 3.477176e-01 0.459
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 3.498128e-01 0.456
R-HSA-74158 RNA Polymerase III Transcription 3.498128e-01 0.456
R-HSA-9682385 FLT3 signaling in disease 3.498128e-01 0.456
R-HSA-8941326 RUNX2 regulates bone development 3.498128e-01 0.456
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 3.503741e-01 0.455
R-HSA-199991 Membrane Trafficking 3.540081e-01 0.451
R-HSA-68877 Mitotic Prometaphase 3.558705e-01 0.449
R-HSA-933541 TRAF6 mediated IRF7 activation 3.562985e-01 0.448
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.562985e-01 0.448
R-HSA-5689896 Ovarian tumor domain proteases 3.562985e-01 0.448
R-HSA-72163 mRNA Splicing - Major Pathway 3.585855e-01 0.445
R-HSA-8875878 MET promotes cell motility 3.627199e-01 0.440
R-HSA-5213460 RIPK1-mediated regulated necrosis 3.627199e-01 0.440
R-HSA-1566948 Elastic fibre formation 3.627199e-01 0.440
R-HSA-9609690 HCMV Early Events 3.640109e-01 0.439
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 3.690776e-01 0.433
R-HSA-4420097 VEGFA-VEGFR2 Pathway 3.699576e-01 0.432
R-HSA-69278 Cell Cycle, Mitotic 3.722378e-01 0.429
R-HSA-373760 L1CAM interactions 3.735208e-01 0.428
R-HSA-9646399 Aggrephagy 3.753723e-01 0.426
R-HSA-3371568 Attenuation phase 3.753723e-01 0.426
R-HSA-9007101 Rab regulation of trafficking 3.770759e-01 0.424
R-HSA-913531 Interferon Signaling 3.789178e-01 0.421
R-HSA-2219528 PI3K/AKT Signaling in Cancer 3.806227e-01 0.420
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 3.816046e-01 0.418
R-HSA-8853884 Transcriptional Regulation by VENTX 3.816046e-01 0.418
R-HSA-9607240 FLT3 Signaling 3.816046e-01 0.418
R-HSA-73933 Resolution of Abasic Sites (AP sites) 3.816046e-01 0.418
R-HSA-376176 Signaling by ROBO receptors 3.829388e-01 0.417
R-HSA-1257604 PIP3 activates AKT signaling 3.865266e-01 0.413
R-HSA-68875 Mitotic Prophase 3.876910e-01 0.412
R-HSA-5655302 Signaling by FGFR1 in disease 3.877751e-01 0.411
R-HSA-72172 mRNA Splicing 3.883257e-01 0.411
R-HSA-9759194 Nuclear events mediated by NFE2L2 3.912120e-01 0.408
R-HSA-110329 Cleavage of the damaged pyrimidine 3.938844e-01 0.405
R-HSA-73928 Depyrimidination 3.938844e-01 0.405
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 3.938844e-01 0.405
R-HSA-2132295 MHC class II antigen presentation 3.982270e-01 0.400
R-HSA-5654743 Signaling by FGFR4 3.999331e-01 0.398
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 4.059218e-01 0.392
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 4.086793e-01 0.389
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 4.086793e-01 0.389
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 4.086793e-01 0.389
R-HSA-194138 Signaling by VEGF 4.086793e-01 0.389
R-HSA-5654741 Signaling by FGFR3 4.118511e-01 0.385
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 4.177216e-01 0.379
R-HSA-2299718 Condensation of Prophase Chromosomes 4.177216e-01 0.379
R-HSA-9839373 Signaling by TGFBR3 4.177216e-01 0.379
R-HSA-9675135 Diseases of DNA repair 4.177216e-01 0.379
R-HSA-187037 Signaling by NTRK1 (TRKA) 4.190436e-01 0.378
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 4.235339e-01 0.373
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 4.292885e-01 0.367
R-HSA-5620924 Intraflagellar transport 4.292885e-01 0.367
R-HSA-9634597 GPER1 signaling 4.292885e-01 0.367
R-HSA-9031628 NGF-stimulated transcription 4.292885e-01 0.367
R-HSA-1474165 Reproduction 4.293161e-01 0.367
R-HSA-157858 Gap junction trafficking and regulation 4.349860e-01 0.362
R-HSA-3371571 HSF1-dependent transactivation 4.462120e-01 0.350
R-HSA-9864848 Complex IV assembly 4.462120e-01 0.350
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 4.490243e-01 0.348
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 4.517416e-01 0.345
R-HSA-112382 Formation of RNA Pol II elongation complex 4.517416e-01 0.345
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 4.517416e-01 0.345
R-HSA-9634815 Transcriptional Regulation by NPAS4 4.517416e-01 0.345
R-HSA-9705683 SARS-CoV-2-host interactions 4.518848e-01 0.345
R-HSA-9018519 Estrogen-dependent gene expression 4.529079e-01 0.344
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 4.562333e-01 0.341
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 4.572163e-01 0.340
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 4.572163e-01 0.340
R-HSA-75955 RNA Polymerase II Transcription Elongation 4.572163e-01 0.340
R-HSA-1221632 Meiotic synapsis 4.572163e-01 0.340
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 4.626367e-01 0.335
R-HSA-73929 Base-Excision Repair, AP Site Formation 4.626367e-01 0.335
R-HSA-6807070 PTEN Regulation 4.628494e-01 0.335
R-HSA-381119 Unfolded Protein Response (UPR) 4.628494e-01 0.335
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 4.680033e-01 0.330
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 4.680033e-01 0.330
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 4.733166e-01 0.325
R-HSA-5654736 Signaling by FGFR1 4.733166e-01 0.325
R-HSA-177929 Signaling by EGFR 4.733166e-01 0.325
R-HSA-109606 Intrinsic Pathway for Apoptosis 4.733166e-01 0.325
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 4.759400e-01 0.322
R-HSA-2980766 Nuclear Envelope Breakdown 4.785772e-01 0.320
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 4.785772e-01 0.320
R-HSA-8856828 Clathrin-mediated endocytosis 4.791826e-01 0.319
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 4.837856e-01 0.315
R-HSA-429914 Deadenylation-dependent mRNA decay 4.889422e-01 0.311
R-HSA-186712 Regulation of beta-cell development 4.889422e-01 0.311
R-HSA-9006925 Intracellular signaling by second messengers 4.903740e-01 0.309
R-HSA-199977 ER to Golgi Anterograde Transport 4.920306e-01 0.308
R-HSA-8943724 Regulation of PTEN gene transcription 4.940477e-01 0.306
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 4.940477e-01 0.306
R-HSA-166520 Signaling by NTRKs 4.952116e-01 0.305
R-HSA-9793380 Formation of paraxial mesoderm 4.991025e-01 0.302
R-HSA-8953897 Cellular responses to stimuli 5.016623e-01 0.300
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 5.041070e-01 0.297
R-HSA-9616222 Transcriptional regulation of granulopoiesis 5.041070e-01 0.297
R-HSA-186797 Signaling by PDGF 5.041070e-01 0.297
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.046790e-01 0.297
R-HSA-9694516 SARS-CoV-2 Infection 5.052850e-01 0.296
R-HSA-9609646 HCMV Infection 5.077014e-01 0.294
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 5.078094e-01 0.294
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 5.090619e-01 0.293
R-HSA-380259 Loss of Nlp from mitotic centrosomes 5.090619e-01 0.293
R-HSA-5693532 DNA Double-Strand Break Repair 5.109270e-01 0.292
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 5.140318e-01 0.289
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.188246e-01 0.285
R-HSA-1234174 Cellular response to hypoxia 5.188246e-01 0.285
R-HSA-8854518 AURKA Activation by TPX2 5.236333e-01 0.281
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 5.236333e-01 0.281
R-HSA-69620 Cell Cycle Checkpoints 5.272689e-01 0.278
R-HSA-73894 DNA Repair 5.283244e-01 0.277
R-HSA-9830369 Kidney development 5.283943e-01 0.277
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 5.331079e-01 0.273
R-HSA-5218859 Regulated Necrosis 5.331079e-01 0.273
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 5.423953e-01 0.266
R-HSA-204005 COPII-mediated vesicle transport 5.423953e-01 0.266
R-HSA-195253 Degradation of beta-catenin by the destruction complex 5.423953e-01 0.266
R-HSA-9764560 Regulation of CDH1 Gene Transcription 5.423953e-01 0.266
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 5.423953e-01 0.266
R-HSA-453276 Regulation of mitotic cell cycle 5.469699e-01 0.262
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 5.469699e-01 0.262
R-HSA-5620920 Cargo trafficking to the periciliary membrane 5.469699e-01 0.262
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.514990e-01 0.258
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 5.514990e-01 0.258
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 5.559832e-01 0.255
R-HSA-69052 Switching of origins to a post-replicative state 5.559832e-01 0.255
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.559832e-01 0.255
R-HSA-674695 RNA Polymerase II Pre-transcription Events 5.604227e-01 0.251
R-HSA-1226099 Signaling by FGFR in disease 5.604227e-01 0.251
R-HSA-9013694 Signaling by NOTCH4 5.604227e-01 0.251
R-HSA-380287 Centrosome maturation 5.648182e-01 0.248
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 5.648182e-01 0.248
R-HSA-418555 G alpha (s) signalling events 5.676680e-01 0.246
R-HSA-9909648 Regulation of PD-L1(CD274) expression 5.705207e-01 0.244
R-HSA-9694635 Translation of Structural Proteins 5.734785e-01 0.241
R-HSA-446728 Cell junction organization 5.742535e-01 0.241
R-HSA-383280 Nuclear Receptor transcription pathway 5.777442e-01 0.238
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 5.777442e-01 0.238
R-HSA-191273 Cholesterol biosynthesis 5.777442e-01 0.238
R-HSA-5654738 Signaling by FGFR2 5.861489e-01 0.232
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 5.861489e-01 0.232
R-HSA-6806834 Signaling by MET 5.861489e-01 0.232
R-HSA-5693607 Processing of DNA double-strand break ends 5.902886e-01 0.229
R-HSA-5653656 Vesicle-mediated transport 5.911114e-01 0.228
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 5.943872e-01 0.226
R-HSA-201681 TCF dependent signaling in response to WNT 6.010045e-01 0.221
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 6.024626e-01 0.220
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 6.024626e-01 0.220
R-HSA-6802957 Oncogenic MAPK signaling 6.064402e-01 0.217
R-HSA-1500620 Meiosis 6.064402e-01 0.217
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 6.103782e-01 0.214
R-HSA-141424 Amplification of signal from the kinetochores 6.103782e-01 0.214
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 6.103782e-01 0.214
R-HSA-1483257 Phospholipid metabolism 6.118542e-01 0.213
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 6.142770e-01 0.212
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 6.142770e-01 0.212
R-HSA-438064 Post NMDA receptor activation events 6.181371e-01 0.209
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 6.219588e-01 0.206
R-HSA-73884 Base Excision Repair 6.294885e-01 0.201
R-HSA-1912408 Pre-NOTCH Transcription and Translation 6.331973e-01 0.198
R-HSA-2682334 EPH-Ephrin signaling 6.405045e-01 0.193
R-HSA-9772573 Late SARS-CoV-2 Infection Events 6.405045e-01 0.193
R-HSA-68867 Assembly of the pre-replicative complex 6.441036e-01 0.191
R-HSA-389948 Co-inhibition by PD-1 6.448817e-01 0.191
R-HSA-948021 Transport to the Golgi and subsequent modification 6.497871e-01 0.187
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 6.511949e-01 0.186
R-HSA-1483206 Glycerophospholipid biosynthesis 6.522198e-01 0.186
R-HSA-1500931 Cell-Cell communication 6.551691e-01 0.184
R-HSA-6807878 COPI-mediated anterograde transport 6.581457e-01 0.182
R-HSA-8878159 Transcriptional regulation by RUNX3 6.615693e-01 0.179
R-HSA-190236 Signaling by FGFR 6.649589e-01 0.177
R-HSA-9614085 FOXO-mediated transcription 6.683147e-01 0.175
R-HSA-3214847 HATs acetylate histones 6.683147e-01 0.175
R-HSA-212165 Epigenetic regulation of gene expression 6.688217e-01 0.175
R-HSA-422475 Axon guidance 6.711328e-01 0.173
R-HSA-9730414 MITF-M-regulated melanocyte development 6.781025e-01 0.169
R-HSA-9842860 Regulation of endogenous retroelements 6.781830e-01 0.169
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 6.781830e-01 0.169
R-HSA-1483255 PI Metabolism 6.781830e-01 0.169
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 6.877594e-01 0.163
R-HSA-5619507 Activation of HOX genes during differentiation 6.877594e-01 0.163
R-HSA-69239 Synthesis of DNA 6.970527e-01 0.157
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 7.030949e-01 0.153
R-HSA-69002 DNA Replication Pre-Initiation 7.030949e-01 0.153
R-HSA-1912422 Pre-NOTCH Expression and Processing 7.148224e-01 0.146
R-HSA-2262752 Cellular responses to stress 7.174124e-01 0.144
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 7.176816e-01 0.144
R-HSA-3247509 Chromatin modifying enzymes 7.231675e-01 0.141
R-HSA-9675108 Nervous system development 7.239217e-01 0.140
R-HSA-202733 Cell surface interactions at the vascular wall 7.291548e-01 0.137
R-HSA-8939211 ESR-mediated signaling 7.291548e-01 0.137
R-HSA-5693538 Homology Directed Repair 7.342483e-01 0.134
R-HSA-3371556 Cellular response to heat stress 7.421657e-01 0.129
R-HSA-6809371 Formation of the cornified envelope 7.498486e-01 0.125
R-HSA-4839726 Chromatin organization 7.520226e-01 0.124
R-HSA-114608 Platelet degranulation 7.597397e-01 0.119
R-HSA-69481 G2/M Checkpoints 7.597397e-01 0.119
R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.713045e-01 0.113
R-HSA-8856688 Golgi-to-ER retrograde transport 7.738521e-01 0.111
R-HSA-1474228 Degradation of the extracellular matrix 7.738521e-01 0.111
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.761228e-01 0.110
R-HSA-163685 Integration of energy metabolism 7.849809e-01 0.105
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.065454e-01 0.093
R-HSA-69306 DNA Replication 8.207231e-01 0.086
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 8.225257e-01 0.085
R-HSA-195721 Signaling by WNT 8.289572e-01 0.081
R-HSA-9679506 SARS-CoV Infections 8.309705e-01 0.080
R-HSA-9006936 Signaling by TGFB family members 8.329693e-01 0.079
R-HSA-1280218 Adaptive Immune System 8.430986e-01 0.074
R-HSA-5621481 C-type lectin receptors (CLRs) 8.520590e-01 0.070
R-HSA-9764265 Regulation of CDH1 Expression and Function 8.550227e-01 0.068
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 8.550227e-01 0.068
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 8.579274e-01 0.067
R-HSA-611105 Respiratory electron transport 8.621763e-01 0.064
R-HSA-2559583 Cellular Senescence 8.649385e-01 0.063
R-HSA-1474244 Extracellular matrix organization 8.679815e-01 0.061
R-HSA-597592 Post-translational protein modification 8.683202e-01 0.061
R-HSA-69275 G2/M Transition 8.728994e-01 0.059
R-HSA-375276 Peptide ligand-binding receptors 8.728994e-01 0.059
R-HSA-453274 Mitotic G2-G2/M phases 8.754480e-01 0.058
R-HSA-1630316 Glycosaminoglycan metabolism 8.815994e-01 0.055
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 8.851443e-01 0.053
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 8.897073e-01 0.051
R-HSA-9824446 Viral Infection Pathways 8.938439e-01 0.049
R-HSA-6805567 Keratinization 8.972632e-01 0.047
R-HSA-9006931 Signaling by Nuclear Receptors 8.978923e-01 0.047
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 9.033288e-01 0.044
R-HSA-418990 Adherens junctions interactions 9.090383e-01 0.041
R-HSA-8951664 Neddylation 9.117661e-01 0.040
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.214242e-01 0.036
R-HSA-1280215 Cytokine Signaling in Immune system 9.263622e-01 0.033
R-HSA-421270 Cell-cell junction organization 9.349470e-01 0.029
R-HSA-446203 Asparagine N-linked glycosylation 9.377525e-01 0.028
R-HSA-76002 Platelet activation, signaling and aggregation 9.485228e-01 0.023
R-HSA-5673001 RAF/MAP kinase cascade 9.558186e-01 0.020
R-HSA-5684996 MAPK1/MAPK3 signaling 9.588620e-01 0.018
R-HSA-109582 Hemostasis 9.624713e-01 0.017
R-HSA-112315 Transmission across Chemical Synapses 9.687711e-01 0.014
R-HSA-556833 Metabolism of lipids 9.703223e-01 0.013
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.740193e-01 0.011
R-HSA-5683057 MAPK family signaling cascades 9.755659e-01 0.011
R-HSA-168256 Immune System 9.793520e-01 0.009
R-HSA-168249 Innate Immune System 9.842325e-01 0.007
R-HSA-1643685 Disease 9.846448e-01 0.007
R-HSA-500792 GPCR ligand binding 9.853627e-01 0.006
R-HSA-418594 G alpha (i) signalling events 9.869256e-01 0.006
R-HSA-8978868 Fatty acid metabolism 9.869256e-01 0.006
R-HSA-388396 GPCR downstream signalling 9.872850e-01 0.006
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.920204e-01 0.003
R-HSA-112316 Neuronal System 9.930211e-01 0.003
R-HSA-372790 Signaling by GPCR 9.936177e-01 0.003
R-HSA-5663205 Infectious disease 9.964928e-01 0.002
R-HSA-392499 Metabolism of proteins 9.973863e-01 0.001
R-HSA-449147 Signaling by Interleukins 9.986286e-01 0.001
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.736 0.147 1 0.770
CLK2CLK2 0.736 0.200 -3 0.802
COTCOT 0.736 0.122 2 0.401
MOSMOS 0.731 0.150 1 0.802
PIM3PIM3 0.730 0.098 -3 0.852
CAMK2ACAMK2A 0.729 0.166 2 0.391
GRK1GRK1 0.729 0.139 -2 0.816
GSK3BGSK3B 0.729 0.236 4 0.750
CAMK2BCAMK2B 0.728 0.132 2 0.357
RSK2RSK2 0.728 0.111 -3 0.817
GSK3AGSK3A 0.728 0.235 4 0.758
SKMLCKSKMLCK 0.727 0.107 -2 0.881
CDC7CDC7 0.727 0.042 1 0.772
CAMK2GCAMK2G 0.727 0.105 2 0.345
CAMK1BCAMK1B 0.723 0.085 -3 0.875
MTORMTOR 0.723 0.121 1 0.714
GRK6GRK6 0.723 0.136 1 0.784
RIPK3RIPK3 0.723 0.025 3 0.227
MSK1MSK1 0.722 0.134 -3 0.795
DYRK4DYRK4 0.722 0.140 1 0.631
FAM20CFAM20C 0.722 0.020 2 0.253
PASKPASK 0.721 0.294 -3 0.856
P90RSKP90RSK 0.719 0.072 -3 0.822
RSK4RSK4 0.719 0.107 -3 0.792
NDR2NDR2 0.718 0.024 -3 0.846
PIM1PIM1 0.718 0.077 -3 0.824
CDKL1CDKL1 0.717 0.049 -3 0.838
RAF1RAF1 0.716 0.022 1 0.763
IKKBIKKB 0.716 0.011 -2 0.743
DYRK2DYRK2 0.716 0.074 1 0.707
SRPK1SRPK1 0.716 0.048 -3 0.801
CAMK2DCAMK2D 0.715 0.055 -3 0.867
PRPKPRPK 0.715 -0.058 -1 0.720
ATRATR 0.715 0.040 1 0.773
DRAK1DRAK1 0.714 0.164 1 0.726
ERK5ERK5 0.714 0.002 1 0.813
CAMLCKCAMLCK 0.714 0.042 -2 0.856
HUNKHUNK 0.713 -0.006 2 0.395
DAPK2DAPK2 0.713 0.055 -3 0.880
CDKL5CDKL5 0.713 0.029 -3 0.835
NLKNLK 0.713 -0.026 1 0.780
DSTYKDSTYK 0.713 0.009 2 0.408
PKN2PKN2 0.712 0.025 -3 0.866
GRK7GRK7 0.712 0.105 1 0.732
PDHK4PDHK4 0.712 -0.041 1 0.771
HIPK4HIPK4 0.712 0.005 1 0.751
WNK1WNK1 0.712 -0.014 -2 0.899
GRK5GRK5 0.712 0.016 -3 0.813
MAPKAPK2MAPKAPK2 0.711 0.059 -3 0.777
MYLK4MYLK4 0.711 0.085 -2 0.794
CK2A1CK2A1 0.711 0.129 1 0.666
P70S6KBP70S6KB 0.711 0.043 -3 0.839
RIPK1RIPK1 0.711 -0.007 1 0.732
PKN3PKN3 0.711 -0.012 -3 0.858
NUAK2NUAK2 0.711 0.010 -3 0.865
CLK4CLK4 0.711 0.091 -3 0.819
NDR1NDR1 0.710 0.001 -3 0.855
CK2A2CK2A2 0.710 0.099 1 0.686
MSK2MSK2 0.709 0.063 -3 0.790
RSK3RSK3 0.709 0.045 -3 0.806
DNAPKDNAPK 0.709 0.097 1 0.655
DLKDLK 0.708 0.104 1 0.753
ICKICK 0.708 0.023 -3 0.861
MASTLMASTL 0.707 -0.030 -2 0.797
PKACGPKACG 0.707 0.026 -2 0.755
NIKNIK 0.706 -0.036 -3 0.880
PAK1PAK1 0.706 0.011 -2 0.809
GRK4GRK4 0.706 0.007 -2 0.829
MST4MST4 0.705 -0.048 2 0.358
CDK1CDK1 0.705 0.055 1 0.634
PRKXPRKX 0.705 0.089 -3 0.739
CLK1CLK1 0.705 0.070 -3 0.799
PRKD1PRKD1 0.705 -0.021 -3 0.847
ATMATM 0.704 0.021 1 0.716
CAMK1GCAMK1G 0.704 0.061 -3 0.823
BMPR1BBMPR1B 0.704 0.091 1 0.760
PRKD2PRKD2 0.704 0.008 -3 0.815
JNK2JNK2 0.704 0.074 1 0.606
SRPK3SRPK3 0.703 0.023 -3 0.777
MARK4MARK4 0.703 -0.050 4 0.745
BMPR2BMPR2 0.703 -0.127 -2 0.850
JNK3JNK3 0.703 0.063 1 0.637
GCN2GCN2 0.702 -0.145 2 0.329
IKKEIKKE 0.702 -0.070 1 0.667
CAMK4CAMK4 0.702 -0.001 -3 0.849
PKACBPKACB 0.702 0.061 -2 0.692
MLK1MLK1 0.702 -0.085 2 0.342
MAPKAPK3MAPKAPK3 0.702 -0.007 -3 0.818
TBK1TBK1 0.701 -0.111 1 0.667
AMPKA1AMPKA1 0.701 -0.061 -3 0.870
AURCAURC 0.700 0.016 -2 0.681
TGFBR1TGFBR1 0.700 0.038 -2 0.752
IKKAIKKA 0.700 -0.015 -2 0.730
PLK1PLK1 0.700 0.008 -2 0.745
SRPK2SRPK2 0.700 0.025 -3 0.743
LATS1LATS1 0.699 0.061 -3 0.849
KISKIS 0.699 -0.005 1 0.668
NIM1NIM1 0.699 -0.089 3 0.200
PKCDPKCD 0.698 -0.059 2 0.311
GAKGAK 0.698 0.227 1 0.839
AURAAURA 0.698 0.047 -2 0.651
YANK3YANK3 0.698 0.044 2 0.207
PDHK1PDHK1 0.698 -0.173 1 0.757
ANKRD3ANKRD3 0.698 -0.079 1 0.788
ULK2ULK2 0.697 -0.187 2 0.296
CHAK2CHAK2 0.697 -0.096 -1 0.691
AKT2AKT2 0.697 0.053 -3 0.757
PLK3PLK3 0.697 0.036 2 0.375
BRSK1BRSK1 0.697 -0.028 -3 0.830
LATS2LATS2 0.697 -0.029 -5 0.673
DAPK1DAPK1 0.697 0.101 -3 0.829
TSSK2TSSK2 0.697 -0.059 -5 0.776
JNK1JNK1 0.697 0.072 1 0.606
CDK2CDK2 0.696 0.007 1 0.717
AMPKA2AMPKA2 0.696 -0.051 -3 0.851
ALK4ALK4 0.696 -0.005 -2 0.782
PAK3PAK3 0.696 -0.041 -2 0.801
TTBK2TTBK2 0.696 -0.109 2 0.270
HIPK2HIPK2 0.696 0.021 1 0.619
HIPK1HIPK1 0.696 0.017 1 0.712
PKCGPKCG 0.695 -0.045 2 0.310
PKCBPKCB 0.695 -0.047 2 0.304
MEKK3MEKK3 0.695 0.038 1 0.735
DYRK3DYRK3 0.695 0.059 1 0.718
PAK2PAK2 0.695 -0.029 -2 0.789
SMG1SMG1 0.695 0.029 1 0.728
MEK1MEK1 0.695 -0.013 2 0.383
NEK7NEK7 0.694 -0.153 -3 0.823
GRK2GRK2 0.694 0.038 -2 0.723
MNK1MNK1 0.694 -0.024 -2 0.810
AURBAURB 0.694 0.005 -2 0.675
CDK10CDK10 0.694 0.034 1 0.635
MARK3MARK3 0.694 0.001 4 0.689
SMMLCKSMMLCK 0.694 0.057 -3 0.854
ALK2ALK2 0.694 0.042 -2 0.765
WNK3WNK3 0.694 -0.173 1 0.731
BCKDKBCKDK 0.694 -0.125 -1 0.669
QSKQSK 0.694 -0.031 4 0.715
P38BP38B 0.693 0.042 1 0.651
PKCAPKCA 0.693 -0.054 2 0.288
ULK1ULK1 0.693 -0.140 -3 0.796
MLK3MLK3 0.693 -0.080 2 0.306
ACVR2BACVR2B 0.692 0.050 -2 0.738
CDK3CDK3 0.692 0.011 1 0.584
CDK7CDK7 0.691 -0.025 1 0.658
SNRKSNRK 0.691 -0.096 2 0.271
DYRK1BDYRK1B 0.691 0.028 1 0.663
SGK3SGK3 0.691 0.001 -3 0.809
P38AP38A 0.691 0.017 1 0.704
PIM2PIM2 0.691 0.030 -3 0.801
CK1ECK1E 0.690 0.019 -3 0.524
MNK2MNK2 0.690 -0.046 -2 0.802
TSSK1TSSK1 0.690 -0.079 -3 0.883
NEK6NEK6 0.690 -0.155 -2 0.816
CDK8CDK8 0.690 -0.033 1 0.648
PKRPKR 0.689 -0.084 1 0.775
MLK2MLK2 0.689 -0.140 2 0.331
PAK6PAK6 0.689 -0.018 -2 0.721
IRE1IRE1 0.689 -0.146 1 0.729
VRK2VRK2 0.689 -0.141 1 0.800
DYRK1ADYRK1A 0.689 0.012 1 0.691
QIKQIK 0.689 -0.084 -3 0.857
BRSK2BRSK2 0.689 -0.065 -3 0.850
TGFBR2TGFBR2 0.688 -0.127 -2 0.733
PLK2PLK2 0.688 0.068 -3 0.683
CK1A2CK1A2 0.688 0.034 -3 0.484
NEK9NEK9 0.688 -0.184 2 0.322
YSK4YSK4 0.688 -0.020 1 0.695
MARK1MARK1 0.688 -0.028 4 0.696
BMPR1ABMPR1A 0.688 0.054 1 0.729
CDK14CDK14 0.688 0.012 1 0.648
CDK13CDK13 0.688 -0.028 1 0.630
PKCHPKCH 0.688 -0.070 2 0.284
MLK4MLK4 0.688 -0.095 2 0.292
PKCZPKCZ 0.687 -0.080 2 0.304
MAPKAPK5MAPKAPK5 0.687 -0.023 -3 0.792
MST3MST3 0.687 0.005 2 0.382
DAPK3DAPK3 0.687 0.053 -3 0.840
CDK19CDK19 0.687 -0.028 1 0.617
DCAMKL1DCAMKL1 0.687 -0.004 -3 0.822
PKACAPKACA 0.687 0.045 -2 0.641
PKG2PKG2 0.687 -0.011 -2 0.694
CDK18CDK18 0.687 -0.001 1 0.607
ACVR2AACVR2A 0.687 -0.005 -2 0.720
DCAMKL2DCAMKL2 0.687 -0.001 -3 0.840
PRKD3PRKD3 0.686 -0.024 -3 0.793
MELKMELK 0.686 -0.081 -3 0.847
SIKSIK 0.686 -0.041 -3 0.805
CDK9CDK9 0.686 -0.029 1 0.634
ERK1ERK1 0.686 -0.011 1 0.630
MARK2MARK2 0.685 -0.047 4 0.652
GRK3GRK3 0.685 0.033 -2 0.687
P38GP38G 0.685 0.012 1 0.555
ERK2ERK2 0.684 -0.023 1 0.646
HIPK3HIPK3 0.684 -0.018 1 0.695
TLK2TLK2 0.684 -0.067 1 0.744
CDK5CDK5 0.684 -0.042 1 0.683
CDK12CDK12 0.684 -0.023 1 0.604
P70S6KP70S6K 0.684 0.008 -3 0.774
NUAK1NUAK1 0.683 -0.067 -3 0.829
CDK17CDK17 0.683 -0.003 1 0.563
CK1DCK1D 0.683 0.025 -3 0.480
NEK11NEK11 0.682 0.004 1 0.715
PLK4PLK4 0.682 -0.114 2 0.261
CAMK1DCAMK1D 0.681 0.021 -3 0.748
PRP4PRP4 0.681 0.013 -3 0.795
IRE2IRE2 0.681 -0.162 2 0.256
NEK2NEK2 0.680 -0.150 2 0.314
MEK5MEK5 0.680 -0.127 2 0.349
GCKGCK 0.680 0.072 1 0.747
PHKG1PHKG1 0.680 -0.109 -3 0.857
WNK4WNK4 0.680 -0.121 -2 0.883
TTBK1TTBK1 0.679 -0.096 2 0.240
P38DP38D 0.678 0.030 1 0.567
BRAFBRAF 0.678 -0.084 -4 0.759
CHK1CHK1 0.678 -0.062 -3 0.820
ERK7ERK7 0.678 -0.043 2 0.216
CK1G1CK1G1 0.678 -0.031 -3 0.508
PKCEPKCE 0.678 -0.029 2 0.295
STK33STK33 0.677 -0.040 2 0.278
PAK4PAK4 0.677 -0.011 -2 0.658
AKT1AKT1 0.677 0.008 -3 0.774
CHAK1CHAK1 0.677 -0.175 2 0.289
MEKK2MEKK2 0.676 -0.130 2 0.318
MAKMAK 0.676 0.044 -2 0.781
HPK1HPK1 0.676 0.047 1 0.728
CDK16CDK16 0.676 -0.001 1 0.578
SGK1SGK1 0.676 0.046 -3 0.688
MPSK1MPSK1 0.675 -0.040 1 0.776
SSTKSSTK 0.674 -0.087 4 0.683
PKCIPKCI 0.674 -0.074 2 0.290
ZAKZAK 0.674 -0.125 1 0.691
NEK5NEK5 0.674 -0.133 1 0.763
TAK1TAK1 0.673 0.081 1 0.738
TAO3TAO3 0.673 -0.069 1 0.719
TLK1TLK1 0.673 -0.091 -2 0.792
MRCKAMRCKA 0.673 0.035 -3 0.807
MEKK1MEKK1 0.673 -0.179 1 0.736
MOKMOK 0.672 0.021 1 0.757
IRAK1IRAK1 0.671 -0.155 -1 0.634
IRAK4IRAK4 0.671 -0.168 1 0.717
PKCTPKCT 0.671 -0.091 2 0.279
SBKSBK 0.671 0.052 -3 0.657
LKB1LKB1 0.671 -0.056 -3 0.847
CHK2CHK2 0.671 0.022 -3 0.714
PAK5PAK5 0.670 -0.030 -2 0.650
AKT3AKT3 0.669 0.024 -3 0.703
DMPK1DMPK1 0.669 0.065 -3 0.811
PINK1PINK1 0.668 -0.130 1 0.785
MRCKBMRCKB 0.668 0.011 -3 0.796
PERKPERK 0.667 -0.203 -2 0.784
EEF2KEEF2K 0.667 -0.085 3 0.221
HRIHRI 0.667 -0.193 -2 0.796
PDK1PDK1 0.667 -0.077 1 0.705
PHKG2PHKG2 0.667 -0.097 -3 0.839
PKN1PKN1 0.666 -0.042 -3 0.792
CAMKK2CAMKK2 0.666 -0.068 -2 0.735
NEK8NEK8 0.665 -0.146 2 0.324
CAMKK1CAMKK1 0.665 -0.092 -2 0.742
CAMK1ACAMK1A 0.665 0.000 -3 0.721
MST2MST2 0.664 -0.045 1 0.751
ROCK2ROCK2 0.664 -0.005 -3 0.828
KHS2KHS2 0.663 -0.036 1 0.729
YANK2YANK2 0.663 0.025 2 0.203
MEKK6MEKK6 0.663 -0.115 1 0.725
CK1ACK1A 0.662 0.017 -3 0.390
LRRK2LRRK2 0.662 -0.091 2 0.341
TAO2TAO2 0.662 -0.137 2 0.334
CRIKCRIK 0.662 0.042 -3 0.764
NEK4NEK4 0.661 -0.154 1 0.715
VRK1VRK1 0.661 -0.095 2 0.340
CDK6CDK6 0.661 -0.043 1 0.621
RIPK2RIPK2 0.661 -0.124 1 0.649
PBKPBK 0.660 0.009 1 0.798
MAP3K15MAP3K15 0.659 -0.130 1 0.676
KHS1KHS1 0.659 -0.067 1 0.714
CDK4CDK4 0.659 -0.043 1 0.597
MINKMINK 0.658 -0.102 1 0.718
TNIKTNIK 0.657 -0.117 3 0.209
MST1MST1 0.657 -0.055 1 0.728
ALPHAK3ALPHAK3 0.656 0.037 -1 0.657
SLKSLK 0.655 -0.059 -2 0.688
NEK1NEK1 0.655 -0.156 1 0.721
HGKHGK 0.654 -0.138 3 0.220
PDHK3_TYRPDHK3_TYR 0.654 0.197 4 0.835
PDHK4_TYRPDHK4_TYR 0.654 0.259 2 0.419
BMPR2_TYRBMPR2_TYR 0.652 0.255 -1 0.809
ROCK1ROCK1 0.652 -0.005 -3 0.809
LOKLOK 0.651 -0.129 -2 0.748
MAP2K6_TYRMAP2K6_TYR 0.651 0.235 -1 0.759
CK1G2CK1G2 0.650 0.062 -3 0.434
BUB1BUB1 0.649 -0.069 -5 0.724
PKG1PKG1 0.647 -0.034 -2 0.613
MEK2MEK2 0.647 -0.196 2 0.329
PDHK1_TYRPDHK1_TYR 0.646 0.183 -1 0.776
YSK1YSK1 0.646 -0.153 2 0.310
HASPINHASPIN 0.646 -0.062 -1 0.568
BIKEBIKE 0.645 0.021 1 0.772
MAP2K4_TYRMAP2K4_TYR 0.643 0.093 -1 0.738
TTKTTK 0.642 -0.113 -2 0.769
EPHA4EPHA4 0.642 0.106 2 0.409
PTK2PTK2 0.641 0.177 -1 0.809
OSR1OSR1 0.640 -0.109 2 0.340
EPHA6EPHA6 0.640 0.074 -1 0.775
MAP2K7_TYRMAP2K7_TYR 0.638 -0.027 2 0.368
TESK1_TYRTESK1_TYR 0.638 -0.052 3 0.243
CK1G3CK1G3 0.637 -0.005 -3 0.346
FYNFYN 0.637 0.133 -1 0.777
ASK1ASK1 0.637 -0.141 1 0.658
EPHB4EPHB4 0.636 0.026 -1 0.711
MYO3BMYO3B 0.636 -0.127 2 0.315
PKMYT1_TYRPKMYT1_TYR 0.635 -0.093 3 0.238
SRMSSRMS 0.634 0.068 1 0.799
TXKTXK 0.633 0.075 1 0.795
MYO3AMYO3A 0.632 -0.130 1 0.710
BLKBLK 0.631 0.056 -1 0.772
PINK1_TYRPINK1_TYR 0.631 -0.098 1 0.759
EPHB1EPHB1 0.630 0.019 1 0.792
ITKITK 0.630 0.064 -1 0.703
NEK3NEK3 0.629 -0.229 1 0.668
FGRFGR 0.629 -0.003 1 0.827
EPHA7EPHA7 0.629 0.028 2 0.382
TNK2TNK2 0.629 -0.061 3 0.198
DDR2DDR2 0.629 0.027 3 0.221
DDR1DDR1 0.628 -0.030 4 0.745
YES1YES1 0.628 -0.017 -1 0.715
EPHB3EPHB3 0.628 -0.001 -1 0.701
EPHA3EPHA3 0.628 0.022 2 0.368
EPHB2EPHB2 0.628 0.021 -1 0.701
INSRRINSRR 0.627 -0.061 3 0.198
EPHA5EPHA5 0.627 0.052 2 0.399
TAO1TAO1 0.627 -0.170 1 0.636
AAK1AAK1 0.626 0.029 1 0.696
FGFR2FGFR2 0.625 -0.030 3 0.252
LIMK2_TYRLIMK2_TYR 0.625 -0.130 -3 0.881
BMXBMX 0.625 0.037 -1 0.636
EPHA8EPHA8 0.624 0.039 -1 0.736
FLT1FLT1 0.623 0.061 -1 0.742
FERFER 0.623 -0.064 1 0.815
LCKLCK 0.623 0.012 -1 0.771
HCKHCK 0.623 -0.029 -1 0.753
PTK2BPTK2B 0.623 0.003 -1 0.638
MST1RMST1R 0.623 -0.152 3 0.192
STLK3STLK3 0.623 -0.145 1 0.664
RETRET 0.622 -0.148 1 0.725
SRCSRC 0.622 0.039 -1 0.730
TEKTEK 0.622 -0.070 3 0.184
FGFR3FGFR3 0.622 -0.003 3 0.242
EPHA2EPHA2 0.621 0.060 -1 0.707
SYKSYK 0.621 0.135 -1 0.762
JAK3JAK3 0.621 -0.052 1 0.694
KDRKDR 0.620 -0.079 3 0.191
TYRO3TYRO3 0.619 -0.188 3 0.176
MERTKMERTK 0.619 -0.091 3 0.194
METMET 0.619 -0.041 3 0.189
ABL2ABL2 0.619 -0.104 -1 0.676
KITKIT 0.619 -0.051 3 0.200
CSF1RCSF1R 0.618 -0.133 3 0.181
ERBB4ERBB4 0.618 0.054 1 0.675
AXLAXL 0.617 -0.126 3 0.199
LIMK1_TYRLIMK1_TYR 0.617 -0.224 2 0.322
ABL1ABL1 0.616 -0.098 -1 0.665
ROS1ROS1 0.616 -0.248 3 0.166
ERBB2ERBB2 0.615 -0.047 1 0.709
LYNLYN 0.615 -0.019 3 0.175
FLT4FLT4 0.614 -0.072 3 0.217
TECTEC 0.614 -0.054 -1 0.608
FRKFRK 0.613 -0.044 -1 0.746
EPHA1EPHA1 0.613 -0.099 3 0.175
FGFR1FGFR1 0.611 -0.151 3 0.195
NTRK1NTRK1 0.611 -0.126 -1 0.670
CSKCSK 0.611 -0.045 2 0.368
TYK2TYK2 0.610 -0.307 1 0.725
JAK2JAK2 0.610 -0.264 1 0.710
WEE1_TYRWEE1_TYR 0.610 -0.090 -1 0.612
LTKLTK 0.609 -0.156 3 0.186
TNK1TNK1 0.608 -0.189 3 0.171
INSRINSR 0.607 -0.142 3 0.179
FGFR4FGFR4 0.607 -0.028 -1 0.636
PDGFRBPDGFRB 0.606 -0.232 3 0.188
EGFREGFR 0.606 -0.016 1 0.628
BTKBTK 0.606 -0.117 -1 0.646
ALKALK 0.605 -0.202 3 0.166
IGF1RIGF1R 0.605 -0.089 3 0.180
NTRK3NTRK3 0.603 -0.125 -1 0.629
FLT3FLT3 0.603 -0.188 3 0.173
MATKMATK 0.602 -0.076 -1 0.603
PTK6PTK6 0.600 -0.171 -1 0.588
NEK10_TYRNEK10_TYR 0.600 -0.156 1 0.570
NTRK2NTRK2 0.600 -0.201 3 0.196
JAK1JAK1 0.600 -0.211 1 0.662
TNNI3K_TYRTNNI3K_TYR 0.599 -0.195 1 0.737
ZAP70ZAP70 0.598 0.045 -1 0.690
PDGFRAPDGFRA 0.598 -0.271 3 0.181
FESFES 0.594 -0.065 -1 0.598
MUSKMUSK 0.584 -0.139 1 0.644