Motif 491 (n=187)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| F8WAN1 | SPECC1L-ADORA2A | S835 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| O00560 | SDCBP | S36 | ochoa | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. |
| O14686 | KMT2D | S373 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14920 | IKBKB | S695 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15069 | NACAD | S1133 | ochoa | NAC-alpha domain-containing protein 1 | May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| O15355 | PPM1G | S245 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15432 | SLC31A2 | S77 | ochoa | Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2) | Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity). {ECO:0000250|UniProtKB:Q9CPU9, ECO:0000269|PubMed:17617060, ECO:0000269|PubMed:17944601}. |
| O15439 | ABCC4 | S638 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43294 | TGFB1I1 | S140 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43395 | PRPF3 | S164 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:20595234}. |
| O43491 | EPB41L2 | S658 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43663 | PRC1 | S557 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O75152 | ZC3H11A | S129 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75886 | STAM2 | S375 | ochoa | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
| O75962 | TRIO | S2370 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O75970 | MPDZ | S1587 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O94806 | PRKD3 | S216 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O95210 | STBD1 | S58 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95551 | TDP2 | S98 | ochoa | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27060144, PubMed:27099339). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584, ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489, ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062, ECO:0000269|PubMed:24658003, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339}.; FUNCTION: (Microbial infection) Used by picornaviruses to remove the small polypeptide, VPg (virus Protein genome-linked, the primer for viral RNA synthesis), from the genomic RNA of the virus. Acts as a 5'-tyrosyl RNA phosphodiesterase and cleaves the covalent VPg-Tyr-RNA bond. This cleavage would play a role in viral replication and occur in viral replication vesicles, but would not act on viral mRNA. {ECO:0000269|PubMed:22908287, ECO:0000269|PubMed:32023921}. |
| O95782 | AP2A1 | S652 | ochoa | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P00450 | CP | S499 | ochoa | Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) (Glutathione peroxidase ceruloplasmin) (EC 1.11.1.9) (Glutathione-dependent peroxiredoxin ceruloplasmin) (EC 1.11.1.27) | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150). {ECO:0000250|UniProtKB:P13635, ECO:0000269|PubMed:10481051, ECO:0000269|PubMed:14623105, ECO:0000269|PubMed:16150804, ECO:0000269|PubMed:16906150, ECO:0000269|PubMed:4643313, ECO:0000269|PubMed:5912351}. |
| P04406 | GAPDH | S125 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P07814 | EPRS1 | S883 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08069 | IGF1R | S1311 | ochoa|psp | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08069 | IGF1R | S1313 | ochoa|psp | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08670 | VIM | S412 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P15144 | ANPEP | S247 | ochoa | Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13) | Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). {ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485, ECO:0000269|PubMed:9367365}.; FUNCTION: (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}. |
| P18846 | ATF1 | S189 | ochoa | Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| P27448 | MARK3 | S546 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P30307 | CDC25C | S64 | ochoa | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P35269 | GTF2F1 | S436 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P37275 | ZEB1 | S645 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P37275 | ZEB1 | S701 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P42166 | TMPO | S159 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42566 | EPS15 | S669 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46013 | MKI67 | S1751 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S1995 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S1782 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S355 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49023 | PXN | S227 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49137 | MAPKAPK2 | S219 | ochoa | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}. |
| P49757 | NUMB | S241 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49790 | NUP153 | S519 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1514 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50570 | DNM2 | S745 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
| P50616 | TOB1 | S151 | ochoa | Protein Tob1 (Transducer of erbB-2 1) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}. |
| P51659 | HSD17B4 | S612 | ochoa | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P51787 | KCNQ1 | S95 | psp | Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| P53396 | ACLY | S446 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P55211 | CASP9 | S310 | ochoa | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}. |
| P55265 | ADAR | S611 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P63244 | RACK1 | S279 | ochoa | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
| P78559 | MAP1A | S1157 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98082 | DAB2 | S264 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| P98082 | DAB2 | S393 | ochoa|psp | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01082 | SPTBN1 | S2164 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01780 | EXOSC10 | S593 | ochoa | Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250|UniProtKB:P56960, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:25632158, ECO:0000269|PubMed:26857222, ECO:0000269|PubMed:31086179, ECO:0000269|PubMed:32830871, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36912080}. |
| Q05209 | PTPN12 | S517 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08J23 | NSUN2 | S724 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q09666 | AHNAK | S5400 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12767 | TMEM94 | S457 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12906 | ILF3 | S506 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12912 | IRAG2 | S182 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13127 | REST | S864 | ochoa|psp | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q14118 | DAG1 | S807 | ochoa | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] | The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}. |
| Q14126 | DSG2 | S887 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14149 | MORC3 | S500 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14157 | UBAP2L | S266 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14157 | UBAP2L | S836 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14247 | CTTN | S438 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14676 | MDC1 | S763 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14694 | USP10 | S81 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14980 | NUMA1 | S161 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15642 | TRIP10 | S299 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q15691 | MAPRE1 | S140 | ochoa | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
| Q16625 | OCLN | S344 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q3KQU3 | MAP7D1 | S457 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4KMQ1 | TPRN | S369 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q4VC05 | BCL7A | S113 | ochoa | B-cell CLL/lymphoma 7 protein family member A | None |
| Q5UIP0 | RIF1 | S1666 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT52 | RPRD2 | S476 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VWJ9 | SNX30 | S37 | ochoa | Sorting nexin-30 | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}. |
| Q63ZY3 | KANK2 | S175 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q66K14 | TBC1D9B | S419 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q676U5 | ATG16L1 | S290 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q69YQ0 | SPECC1L | S835 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6IAA8 | LAMTOR1 | S113 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6P2E9 | EDC4 | S586 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P3S1 | DENND1B | S579 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6P3S6 | FBXO42 | S370 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PJG2 | MIDEAS | S648 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6R327 | RICTOR | S1373 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6WKZ4 | RAB11FIP1 | S342 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6WKZ4 | RAB11FIP1 | S392 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZVL6 | KIAA1549L | S1476 | ochoa | UPF0606 protein KIAA1549L | None |
| Q71RC2 | LARP4 | S586 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q7RTP6 | MICAL3 | S1352 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2W4 | ZC3HAV1 | S390 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3K3 | POGZ | S1367 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z460 | CLASP1 | S1088 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z4S6 | KIF21A | S521 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z7L1 | SLFN11 | S753 | psp | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86SQ0 | PHLDB2 | S937 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UU0 | BCL9L | S93 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86VQ1 | GLCCI1 | S397 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86VR2 | RETREG3 | S350 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86VY9 | TMEM200A | S326 | ochoa | Transmembrane protein 200A | None |
| Q86YP4 | GATAD2A | T188 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IVT2 | MISP | S397 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IYB1 | MB21D2 | S436 | ochoa | Nucleotidyltransferase MB21D2 (EC 2.7.7.-) (Mab-21 domain-containing protein 2) (hMB21D2) | Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. {ECO:0000305|PubMed:34261127}. |
| Q8IZ21 | PHACTR4 | S291 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N3V7 | SYNPO | S743 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N4N8 | KIF2B | S204 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N684 | CPSF7 | S325 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8N8S7 | ENAH | S488 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8N8S7 | ENAH | S531 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8NBJ4 | GOLM1 | S204 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8ND24 | RNF214 | S500 | ochoa | RING finger protein 214 | None |
| Q8NDX5 | PHC3 | S661 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NFC6 | BOD1L1 | S1101 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHV4 | NEDD1 | S549 | ochoa | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TBZ3 | WDR20 | S360 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TE67 | EPS8L3 | S444 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
| Q8WUM4 | PDCD6IP | S721 | psp | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q8WUY3 | PRUNE2 | S1762 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WX93 | PALLD | S632 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q92503 | SEC14L1 | S226 | ochoa | SEC14-like protein 1 | May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}. |
| Q92570 | NR4A3 | S390 | ochoa | Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) | Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}. |
| Q92576 | PHF3 | S1181 | ochoa | PHD finger protein 3 | None |
| Q92610 | ZNF592 | S145 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92615 | LARP4B | Y596 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92835 | INPP5D | S1027 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q969V6 | MRTFA | S136 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96CC6 | RHBDF1 | S136 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96HR8 | NAF1 | S34 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
| Q96I25 | RBM17 | S291 | ochoa|psp | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96JM3 | CHAMP1 | S142 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96MY1 | NOL4L | S389 | ochoa | Nucleolar protein 4-like | None |
| Q96RG2 | PASK | S19 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96T58 | SPEN | S2466 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99459 | CDC5L | S393 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99459 | CDC5L | S427 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99501 | GAS2L1 | S489 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99575 | POP1 | S65 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q9BQE9 | BCL7B | S111 | ochoa | B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}. |
| Q9BUR4 | WRAP53 | S74 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BY43 | CHMP4A | S196 | ochoa | Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:22660413}. |
| Q9GZR1 | SENP6 | S361 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9H0F6 | SHARPIN | S143 | ochoa | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9H4M7 | PLEKHA4 | S244 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H6S3 | EPS8L2 | S466 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H8V3 | ECT2 | S370 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H9A7 | RMI1 | S275 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9H9S0 | NANOG | S68 | psp | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}. |
| Q9HB19 | PLEKHA2 | S352 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9HCD5 | NCOA5 | S381 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9NPF5 | DMAP1 | S412 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
| Q9NQS7 | INCENP | S411 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQW6 | ANLN | S48 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQW6 | ANLN | S339 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQX3 | GPHN | S283 | ochoa | Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}. |
| Q9NRA8 | EIF4ENIF1 | S690 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRR5 | UBQLN4 | S100 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9NWQ8 | PAG1 | S333 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NZN5 | ARHGEF12 | S634 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P1Y5 | CAMSAP3 | S588 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9UGP4 | LIMD1 | S387 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UJU6 | DBNL | S272 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q9ULH1 | ASAP1 | S782 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULM3 | YEATS2 | S468 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UMZ2 | SYNRG | S855 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPM8 | AP4E1 | S871 | psp | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UPS6 | SETD1B | S1770 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9Y2W1 | THRAP3 | S220 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4F5 | CEP170B | S721 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6I3 | EPN1 | S489 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6X8 | ZHX2 | S625 | ochoa | Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) | Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}. |
| P55072 | VCP | S40 | Sugiyama | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| Q14671 | PUM1 | S183 | Sugiyama | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| O14965 | AURKA | S83 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| P15880 | RPS2 | S206 | Sugiyama | Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250|UniProtKB:P25443, ECO:0000269|PubMed:23636399}. |
| P20248 | CCNA2 | S133 | Sugiyama | Cyclin-A2 (Cyclin-A) (Cyclin A) | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}. |
| O95456 | PSMG1 | S183 | Sugiyama | Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2) (Proteasome chaperone homolog 1) (Pba1) | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
| P50416 | CPT1A | S371 | Sugiyama | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:16651524, ECO:0000269|PubMed:29425493, ECO:0000269|PubMed:38016475, ECO:0000269|PubMed:9691089}. |
| P10636 | MAPT | S355 | SIGNOR | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P30101 | PDIA3 | S367 | Sugiyama | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| Q59H18 | TNNI3K | S427 | Sugiyama | Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) | May play a role in cardiac physiology. {ECO:0000303|PubMed:12721663}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000139 | 3.857 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.000232 | 3.634 |
| R-HSA-177929 | Signaling by EGFR | 0.000187 | 3.727 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.000516 | 3.287 |
| R-HSA-75153 | Apoptotic execution phase | 0.000684 | 3.165 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.001148 | 2.940 |
| R-HSA-182971 | EGFR downregulation | 0.001355 | 2.868 |
| R-HSA-73887 | Death Receptor Signaling | 0.001732 | 2.761 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.002543 | 2.595 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.002143 | 2.669 |
| R-HSA-4839726 | Chromatin organization | 0.002494 | 2.603 |
| R-HSA-5357801 | Programmed Cell Death | 0.002513 | 2.600 |
| R-HSA-199920 | CREB phosphorylation | 0.006001 | 2.222 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.005209 | 2.283 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.004781 | 2.320 |
| R-HSA-1640170 | Cell Cycle | 0.005630 | 2.250 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.007302 | 2.137 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.007302 | 2.137 |
| R-HSA-196025 | Formation of annular gap junctions | 0.008817 | 2.055 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.008837 | 2.054 |
| R-HSA-75893 | TNF signaling | 0.009328 | 2.030 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.009582 | 2.019 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.008817 | 2.055 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.009328 | 2.030 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.009829 | 2.007 |
| R-HSA-190873 | Gap junction degradation | 0.010407 | 1.983 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.010306 | 1.987 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.011436 | 1.942 |
| R-HSA-422475 | Axon guidance | 0.013754 | 1.862 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.013653 | 1.865 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.013933 | 1.856 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.014143 | 1.849 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.015136 | 1.820 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.025020 | 1.602 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.025020 | 1.602 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.025020 | 1.602 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.025020 | 1.602 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.025020 | 1.602 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.022287 | 1.652 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.020043 | 1.698 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.021130 | 1.675 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.025020 | 1.602 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.020043 | 1.698 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.016221 | 1.790 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.016519 | 1.782 |
| R-HSA-68877 | Mitotic Prometaphase | 0.019283 | 1.715 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.018227 | 1.739 |
| R-HSA-199991 | Membrane Trafficking | 0.024134 | 1.617 |
| R-HSA-8876725 | Protein methylation | 0.024629 | 1.609 |
| R-HSA-373760 | L1CAM interactions | 0.025798 | 1.588 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.022287 | 1.652 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.024629 | 1.609 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.024602 | 1.609 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.019706 | 1.705 |
| R-HSA-9675108 | Nervous system development | 0.022320 | 1.651 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.024602 | 1.609 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.022287 | 1.652 |
| R-HSA-9833482 | PKR-mediated signaling | 0.026460 | 1.577 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.016485 | 1.783 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.024629 | 1.609 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.019515 | 1.710 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.023224 | 1.634 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.021003 | 1.678 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.020313 | 1.692 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.021998 | 1.658 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.027067 | 1.568 |
| R-HSA-109581 | Apoptosis | 0.028130 | 1.551 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.030421 | 1.517 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.029650 | 1.528 |
| R-HSA-68882 | Mitotic Anaphase | 0.031891 | 1.496 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.032513 | 1.488 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.032219 | 1.492 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.032169 | 1.493 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.037296 | 1.428 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.037296 | 1.428 |
| R-HSA-5083628 | Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | 0.037296 | 1.428 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.035841 | 1.446 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.037989 | 1.420 |
| R-HSA-437239 | Recycling pathway of L1 | 0.033479 | 1.475 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.037722 | 1.423 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.035021 | 1.456 |
| R-HSA-68886 | M Phase | 0.033887 | 1.470 |
| R-HSA-9766229 | Degradation of CDH1 | 0.036598 | 1.437 |
| R-HSA-180292 | GAB1 signalosome | 0.034928 | 1.457 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.035021 | 1.456 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.036536 | 1.437 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.049417 | 1.306 |
| R-HSA-5083633 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | 0.049417 | 1.306 |
| R-HSA-5083629 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | 0.049417 | 1.306 |
| R-HSA-5619049 | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | 0.049417 | 1.306 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.061387 | 1.212 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.061387 | 1.212 |
| R-HSA-5619060 | Defective CP causes aceruloplasminemia (ACERULOP) | 0.073207 | 1.135 |
| R-HSA-68911 | G2 Phase | 0.084878 | 1.071 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.096404 | 1.016 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.096404 | 1.016 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.119023 | 0.924 |
| R-HSA-8932506 | DAG1 core M1 glycosylations | 0.119023 | 0.924 |
| R-HSA-8932504 | DAG1 core M2 glycosylations | 0.130120 | 0.886 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.040599 | 1.391 |
| R-HSA-8932505 | DAG1 core M3 glycosylations | 0.162585 | 0.789 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.073379 | 1.134 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.073379 | 1.134 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.077009 | 1.113 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.080695 | 1.093 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.080695 | 1.093 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.088226 | 1.054 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.088226 | 1.054 |
| R-HSA-390522 | Striated Muscle Contraction | 0.092067 | 1.036 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.092067 | 1.036 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.099891 | 1.000 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.233723 | 0.631 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.056283 | 1.250 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.116059 | 0.935 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.120200 | 0.920 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.062367 | 1.205 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.062367 | 1.205 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.262338 | 0.581 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.262338 | 0.581 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.084708 | 1.072 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.084708 | 1.072 |
| R-HSA-380287 | Centrosome maturation | 0.089536 | 1.048 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.107300 | 0.969 |
| R-HSA-72187 | mRNA 3'-end processing | 0.176785 | 0.753 |
| R-HSA-72649 | Translation initiation complex formation | 0.185836 | 0.731 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.194952 | 0.710 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.236539 | 0.626 |
| R-HSA-6798695 | Neutrophil degranulation | 0.261696 | 0.582 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.131951 | 0.880 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.151900 | 0.818 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.173136 | 0.762 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.111956 | 0.951 |
| R-HSA-111458 | Formation of apoptosome | 0.151900 | 0.818 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.069807 | 1.156 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.119023 | 0.924 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.073379 | 1.134 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.043267 | 1.364 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.104683 | 0.980 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.073207 | 1.135 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.252920 | 0.597 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.054205 | 1.266 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.215254 | 0.667 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.088226 | 1.054 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.119023 | 0.924 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.183555 | 0.736 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.233723 | 0.631 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.223941 | 0.650 |
| R-HSA-5693538 | Homology Directed Repair | 0.235109 | 0.629 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.175664 | 0.755 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.049417 | 1.306 |
| R-HSA-75102 | C6 deamination of adenosine | 0.049417 | 1.306 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.049417 | 1.306 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.096404 | 1.016 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.107785 | 0.967 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.151900 | 0.818 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.173136 | 0.762 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.183555 | 0.736 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.080695 | 1.093 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.214035 | 0.670 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.103871 | 0.984 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.107893 | 0.967 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.058278 | 1.234 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.262338 | 0.581 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.145750 | 0.836 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.067872 | 1.168 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.217964 | 0.662 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.049546 | 1.305 |
| R-HSA-69275 | G2/M Transition | 0.047692 | 1.322 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.252920 | 0.597 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.082338 | 1.084 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.252920 | 0.597 |
| R-HSA-162587 | HIV Life Cycle | 0.073276 | 1.135 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.214035 | 0.670 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.092067 | 1.036 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.223941 | 0.650 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.243382 | 0.614 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.190387 | 0.720 |
| R-HSA-162906 | HIV Infection | 0.095904 | 1.018 |
| R-HSA-8953854 | Metabolism of RNA | 0.045681 | 1.340 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.070545 | 1.152 |
| R-HSA-157579 | Telomere Maintenance | 0.158360 | 0.800 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.147480 | 0.831 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.084878 | 1.071 |
| R-HSA-75072 | mRNA Editing | 0.141079 | 0.851 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.214035 | 0.670 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.095956 | 1.018 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.233723 | 0.631 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.233723 | 0.631 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.262338 | 0.581 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.150112 | 0.824 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.204123 | 0.690 |
| R-HSA-191859 | snRNP Assembly | 0.208726 | 0.680 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.208726 | 0.680 |
| R-HSA-69481 | G2/M Checkpoints | 0.107678 | 0.968 |
| R-HSA-73886 | Chromosome Maintenance | 0.245157 | 0.611 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.050499 | 1.297 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.059456 | 1.226 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.059456 | 1.226 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.195788 | 0.708 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.141079 | 0.851 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.095956 | 1.018 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.060306 | 1.220 |
| R-HSA-180786 | Extension of Telomeres | 0.208726 | 0.680 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.251894 | 0.599 |
| R-HSA-9646399 | Aggrephagy | 0.120200 | 0.920 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.161390 | 0.792 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.161390 | 0.792 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.161390 | 0.792 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.084878 | 1.071 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.119023 | 0.924 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.119023 | 0.924 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.141079 | 0.851 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.183555 | 0.736 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.183555 | 0.736 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.204003 | 0.690 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.214035 | 0.670 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.120200 | 0.920 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.120200 | 0.920 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.124377 | 0.905 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.262338 | 0.581 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.083281 | 1.079 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.195788 | 0.708 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.269210 | 0.570 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.199002 | 0.701 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.202229 | 0.694 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.238451 | 0.623 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.214035 | 0.670 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.204123 | 0.690 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.202229 | 0.694 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.238451 | 0.623 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.248522 | 0.605 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.186227 | 0.730 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.248522 | 0.605 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.211981 | 0.674 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.141079 | 0.851 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.077009 | 1.113 |
| R-HSA-1538133 | G0 and Early G1 | 0.084434 | 1.073 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.221833 | 0.654 |
| R-HSA-450294 | MAP kinase activation | 0.058278 | 1.234 |
| R-HSA-983189 | Kinesins | 0.213340 | 0.671 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.041547 | 1.381 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.106448 | 0.973 |
| R-HSA-9612973 | Autophagy | 0.071903 | 1.143 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.255273 | 0.593 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.096404 | 1.016 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.096404 | 1.016 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.096404 | 1.016 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.162585 | 0.789 |
| R-HSA-171007 | p38MAPK events | 0.214035 | 0.670 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.111956 | 0.951 |
| R-HSA-448424 | Interleukin-17 signaling | 0.077685 | 1.110 |
| R-HSA-190828 | Gap junction trafficking | 0.141415 | 0.850 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.150112 | 0.824 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.264538 | 0.578 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.264538 | 0.578 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.269210 | 0.570 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.243382 | 0.614 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.252920 | 0.597 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.124377 | 0.905 |
| R-HSA-73894 | DNA Repair | 0.209153 | 0.680 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.161034 | 0.793 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.173681 | 0.760 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.145750 | 0.836 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.096404 | 1.016 |
| R-HSA-5689877 | Josephin domain DUBs | 0.151900 | 0.818 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.214035 | 0.670 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.233723 | 0.631 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.243382 | 0.614 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.116059 | 0.935 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.252920 | 0.597 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.163349 | 0.787 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.163349 | 0.787 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.185836 | 0.731 |
| R-HSA-1266738 | Developmental Biology | 0.056956 | 1.244 |
| R-HSA-9659379 | Sensory processing of sound | 0.099526 | 1.002 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.227341 | 0.643 |
| R-HSA-68875 | Mitotic Prophase | 0.092012 | 1.036 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.096404 | 1.016 |
| R-HSA-447043 | Neurofascin interactions | 0.107785 | 0.967 |
| R-HSA-210990 | PECAM1 interactions | 0.162585 | 0.789 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.107893 | 0.967 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.124377 | 0.905 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.073153 | 1.136 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.173681 | 0.760 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.208718 | 0.680 |
| R-HSA-168255 | Influenza Infection | 0.108698 | 0.964 |
| R-HSA-1632852 | Macroautophagy | 0.051908 | 1.285 |
| R-HSA-202403 | TCR signaling | 0.070762 | 1.150 |
| R-HSA-70171 | Glycolysis | 0.167502 | 0.776 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.038477 | 1.415 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.183555 | 0.736 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.073379 | 1.134 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.048639 | 1.313 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.050499 | 1.297 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.115303 | 0.938 |
| R-HSA-73893 | DNA Damage Bypass | 0.163349 | 0.787 |
| R-HSA-5688426 | Deubiquitination | 0.138534 | 0.858 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.120760 | 0.918 |
| R-HSA-74160 | Gene expression (Transcription) | 0.131357 | 0.882 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.052882 | 1.277 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.183555 | 0.736 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.183555 | 0.736 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.095956 | 1.018 |
| R-HSA-6807070 | PTEN Regulation | 0.137730 | 0.861 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.241198 | 0.618 |
| R-HSA-72306 | tRNA processing | 0.093973 | 1.027 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.139345 | 0.856 |
| R-HSA-3371556 | Cellular response to heat stress | 0.093907 | 1.027 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.211829 | 0.674 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.225138 | 0.648 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.214035 | 0.670 |
| R-HSA-9678110 | Attachment and Entry | 0.223941 | 0.650 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.243382 | 0.614 |
| R-HSA-70326 | Glucose metabolism | 0.231777 | 0.635 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.152962 | 0.815 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.227341 | 0.643 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.227341 | 0.643 |
| R-HSA-194138 | Signaling by VEGF | 0.262049 | 0.582 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.241391 | 0.617 |
| R-HSA-418990 | Adherens junctions interactions | 0.186033 | 0.730 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.258663 | 0.587 |
| R-HSA-3928664 | Ephrin signaling | 0.252920 | 0.597 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.060306 | 1.220 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.207919 | 0.682 |
| R-HSA-421270 | Cell-cell junction organization | 0.261088 | 0.583 |
| R-HSA-446728 | Cell junction organization | 0.179107 | 0.747 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.040599 | 1.391 |
| R-HSA-1500931 | Cell-Cell communication | 0.136922 | 0.864 |
| R-HSA-913531 | Interferon Signaling | 0.253580 | 0.596 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.046590 | 1.332 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.077009 | 1.113 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.107893 | 0.967 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.140573 | 0.852 |
| R-HSA-162582 | Signal Transduction | 0.041782 | 1.379 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.111956 | 0.951 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.214035 | 0.670 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.103871 | 0.984 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.252920 | 0.597 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.077479 | 1.111 |
| R-HSA-166520 | Signaling by NTRKs | 0.061442 | 1.212 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.223941 | 0.650 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.116059 | 0.935 |
| R-HSA-5218859 | Regulated Necrosis | 0.073153 | 1.136 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.264538 | 0.578 |
| R-HSA-449147 | Signaling by Interleukins | 0.068961 | 1.161 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.102618 | 0.989 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.088226 | 1.054 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.231885 | 0.635 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.053386 | 1.273 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.189863 | 0.722 |
| R-HSA-1483255 | PI Metabolism | 0.173681 | 0.760 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.252920 | 0.597 |
| R-HSA-9679506 | SARS-CoV Infections | 0.197421 | 0.705 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.204123 | 0.690 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.232715 | 0.633 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.271638 | 0.566 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.271638 | 0.566 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.271638 | 0.566 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.271638 | 0.566 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.271638 | 0.566 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.271638 | 0.566 |
| R-HSA-373753 | Nephrin family interactions | 0.271638 | 0.566 |
| R-HSA-5617833 | Cilium Assembly | 0.273905 | 0.562 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.276697 | 0.558 |
| R-HSA-9939291 | Matriglycan biosynthesis on DAG1 | 0.280822 | 0.552 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.280822 | 0.552 |
| R-HSA-167044 | Signalling to RAS | 0.280822 | 0.552 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.283220 | 0.548 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.285103 | 0.545 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.289890 | 0.538 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 0.289890 | 0.538 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.289890 | 0.538 |
| R-HSA-9694614 | Attachment and Entry | 0.289890 | 0.538 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.289890 | 0.538 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.297206 | 0.527 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.298844 | 0.525 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.298844 | 0.525 |
| R-HSA-8964038 | LDL clearance | 0.298844 | 0.525 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.298844 | 0.525 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.298844 | 0.525 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.306509 | 0.514 |
| R-HSA-6806834 | Signaling by MET | 0.306509 | 0.514 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.307686 | 0.512 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.307686 | 0.512 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.307686 | 0.512 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.307686 | 0.512 |
| R-HSA-200425 | Carnitine shuttle | 0.307686 | 0.512 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.310999 | 0.507 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.313425 | 0.504 |
| R-HSA-72172 | mRNA Splicing | 0.316210 | 0.500 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.316417 | 0.500 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.316417 | 0.500 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.316417 | 0.500 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.316417 | 0.500 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.325039 | 0.488 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.325039 | 0.488 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.325039 | 0.488 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.325039 | 0.488 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.325039 | 0.488 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.329654 | 0.482 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.330652 | 0.481 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.333552 | 0.477 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.333552 | 0.477 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.333552 | 0.477 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.338855 | 0.470 |
| R-HSA-397014 | Muscle contraction | 0.339019 | 0.470 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.341959 | 0.466 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.341959 | 0.466 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.341959 | 0.466 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.341959 | 0.466 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.341959 | 0.466 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.341959 | 0.466 |
| R-HSA-212436 | Generic Transcription Pathway | 0.345336 | 0.462 |
| R-HSA-156902 | Peptide chain elongation | 0.348018 | 0.458 |
| R-HSA-9663891 | Selective autophagy | 0.348018 | 0.458 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.350260 | 0.456 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.350260 | 0.456 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.350260 | 0.456 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.350260 | 0.456 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.350260 | 0.456 |
| R-HSA-5620971 | Pyroptosis | 0.350260 | 0.456 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.352584 | 0.453 |
| R-HSA-9758941 | Gastrulation | 0.354748 | 0.450 |
| R-HSA-202424 | Downstream TCR signaling | 0.357139 | 0.447 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.358184 | 0.446 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.358456 | 0.446 |
| R-HSA-72086 | mRNA Capping | 0.358456 | 0.446 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.358456 | 0.446 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.358456 | 0.446 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.361683 | 0.442 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.365047 | 0.438 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.365047 | 0.438 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.366214 | 0.436 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.366550 | 0.436 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.366550 | 0.436 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.366550 | 0.436 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.366550 | 0.436 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.370733 | 0.431 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.374542 | 0.426 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.374542 | 0.426 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.374542 | 0.426 |
| R-HSA-1989781 | PPARA activates gene expression | 0.375320 | 0.426 |
| R-HSA-9610379 | HCMV Late Events | 0.382151 | 0.418 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.382151 | 0.418 |
| R-HSA-8931838 | DAG1 glycosylations | 0.382434 | 0.417 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.382434 | 0.417 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.384213 | 0.415 |
| R-HSA-9711097 | Cellular response to starvation | 0.385560 | 0.414 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.388679 | 0.410 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.388679 | 0.410 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.390227 | 0.409 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.390227 | 0.409 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.390227 | 0.409 |
| R-HSA-9930044 | Nuclear RNA decay | 0.390227 | 0.409 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.390227 | 0.409 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.390227 | 0.409 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.390227 | 0.409 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.390227 | 0.409 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.390227 | 0.409 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.390227 | 0.409 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.393131 | 0.405 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.397922 | 0.400 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.397922 | 0.400 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.397922 | 0.400 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.397922 | 0.400 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.401990 | 0.396 |
| R-HSA-5673000 | RAF activation | 0.405520 | 0.392 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.405520 | 0.392 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.405520 | 0.392 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.405520 | 0.392 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.405520 | 0.392 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.405520 | 0.392 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.405920 | 0.392 |
| R-HSA-3214847 | HATs acetylate histones | 0.406397 | 0.391 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.410789 | 0.386 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.413023 | 0.384 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.413023 | 0.384 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.413023 | 0.384 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.413023 | 0.384 |
| R-HSA-187687 | Signalling to ERKs | 0.413023 | 0.384 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.415164 | 0.382 |
| R-HSA-5619102 | SLC transporter disorders | 0.416028 | 0.381 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.419524 | 0.377 |
| R-HSA-8853659 | RET signaling | 0.420432 | 0.376 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.420432 | 0.376 |
| R-HSA-3371511 | HSF1 activation | 0.420432 | 0.376 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.420432 | 0.376 |
| R-HSA-192823 | Viral mRNA Translation | 0.423867 | 0.373 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.427747 | 0.369 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.427747 | 0.369 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.427747 | 0.369 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.428193 | 0.368 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.428193 | 0.368 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.429419 | 0.367 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.434971 | 0.362 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 0.434971 | 0.362 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.434971 | 0.362 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.438506 | 0.358 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.441068 | 0.355 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.442104 | 0.354 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.442104 | 0.354 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.442104 | 0.354 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.442104 | 0.354 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.445325 | 0.351 |
| R-HSA-211000 | Gene Silencing by RNA | 0.445325 | 0.351 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.449147 | 0.348 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.449147 | 0.348 |
| R-HSA-167169 | HIV Transcription Elongation | 0.449147 | 0.348 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.449147 | 0.348 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.449147 | 0.348 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.449147 | 0.348 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.449147 | 0.348 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.449147 | 0.348 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.449147 | 0.348 |
| R-HSA-5260271 | Diseases of Immune System | 0.449147 | 0.348 |
| R-HSA-202433 | Generation of second messenger molecules | 0.449147 | 0.348 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.449147 | 0.348 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.449564 | 0.347 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.449564 | 0.347 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.449564 | 0.347 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.456102 | 0.341 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.456102 | 0.341 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.456102 | 0.341 |
| R-HSA-2559583 | Cellular Senescence | 0.462395 | 0.335 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.462969 | 0.334 |
| R-HSA-167161 | HIV Transcription Initiation | 0.462969 | 0.334 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.462969 | 0.334 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.462969 | 0.334 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.462969 | 0.334 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.462969 | 0.334 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.462969 | 0.334 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.466334 | 0.331 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.466334 | 0.331 |
| R-HSA-165159 | MTOR signalling | 0.469751 | 0.328 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.469751 | 0.328 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.469751 | 0.328 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.469751 | 0.328 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.474606 | 0.324 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.476447 | 0.322 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.476447 | 0.322 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.478713 | 0.320 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.482734 | 0.316 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.483058 | 0.316 |
| R-HSA-9907900 | Proteasome assembly | 0.483058 | 0.316 |
| R-HSA-373752 | Netrin-1 signaling | 0.483058 | 0.316 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.483058 | 0.316 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.483058 | 0.316 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.483058 | 0.316 |
| R-HSA-168256 | Immune System | 0.483321 | 0.316 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.486868 | 0.313 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.488177 | 0.311 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.489587 | 0.310 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.489587 | 0.310 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.490916 | 0.309 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.490916 | 0.309 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.496034 | 0.304 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.496034 | 0.304 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.496034 | 0.304 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.496034 | 0.304 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.496034 | 0.304 |
| R-HSA-9675135 | Diseases of DNA repair | 0.496034 | 0.304 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.498952 | 0.302 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.502399 | 0.299 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.502399 | 0.299 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 0.502399 | 0.299 |
| R-HSA-70263 | Gluconeogenesis | 0.508685 | 0.294 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.508685 | 0.294 |
| R-HSA-425410 | Metal ion SLC transporters | 0.508685 | 0.294 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.514891 | 0.288 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.514891 | 0.288 |
| R-HSA-9748787 | Azathioprine ADME | 0.521020 | 0.283 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.521020 | 0.283 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.527071 | 0.278 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.527071 | 0.278 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.527071 | 0.278 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.533047 | 0.273 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.533047 | 0.273 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.533047 | 0.273 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.533047 | 0.273 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.533047 | 0.273 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.533047 | 0.273 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.533047 | 0.273 |
| R-HSA-114608 | Platelet degranulation | 0.537895 | 0.269 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.538947 | 0.268 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.538947 | 0.268 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.538947 | 0.268 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.538947 | 0.268 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.538947 | 0.268 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.544773 | 0.264 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.550526 | 0.259 |
| R-HSA-9753281 | Paracetamol ADME | 0.550526 | 0.259 |
| R-HSA-1474165 | Reproduction | 0.552881 | 0.257 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.556207 | 0.255 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.556207 | 0.255 |
| R-HSA-9843745 | Adipogenesis | 0.556575 | 0.254 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.560246 | 0.252 |
| R-HSA-9909396 | Circadian clock | 0.560246 | 0.252 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.563896 | 0.249 |
| R-HSA-1483257 | Phospholipid metabolism | 0.566601 | 0.247 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.572823 | 0.242 |
| R-HSA-9033241 | Peroxisomal protein import | 0.572823 | 0.242 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.572823 | 0.242 |
| R-HSA-379724 | tRNA Aminoacylation | 0.578223 | 0.238 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.578223 | 0.238 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.578223 | 0.238 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.578223 | 0.238 |
| R-HSA-163685 | Integration of energy metabolism | 0.578278 | 0.238 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.581820 | 0.235 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.583555 | 0.234 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.585339 | 0.233 |
| R-HSA-112316 | Neuronal System | 0.587955 | 0.231 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.588820 | 0.230 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.588820 | 0.230 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.588820 | 0.230 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.588820 | 0.230 |
| R-HSA-186797 | Signaling by PDGF | 0.588820 | 0.230 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.594019 | 0.226 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.594019 | 0.226 |
| R-HSA-8848021 | Signaling by PTK6 | 0.594019 | 0.226 |
| R-HSA-373755 | Semaphorin interactions | 0.594019 | 0.226 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.594019 | 0.226 |
| R-HSA-9824446 | Viral Infection Pathways | 0.597671 | 0.224 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.599152 | 0.222 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.604221 | 0.219 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.604221 | 0.219 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.614168 | 0.212 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.614168 | 0.212 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.614168 | 0.212 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.616032 | 0.210 |
| R-HSA-167172 | Transcription of the HIV genome | 0.619048 | 0.208 |
| R-HSA-72312 | rRNA processing | 0.620487 | 0.207 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.626657 | 0.203 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.628624 | 0.202 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.628624 | 0.202 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.628624 | 0.202 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.628624 | 0.202 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.628624 | 0.202 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.628624 | 0.202 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.633322 | 0.198 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.633322 | 0.198 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.633322 | 0.198 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.633322 | 0.198 |
| R-HSA-3000178 | ECM proteoglycans | 0.633322 | 0.198 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.637960 | 0.195 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.637960 | 0.195 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.642541 | 0.192 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.647063 | 0.189 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.647063 | 0.189 |
| R-HSA-597592 | Post-translational protein modification | 0.649004 | 0.188 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.651529 | 0.186 |
| R-HSA-8852135 | Protein ubiquitination | 0.651529 | 0.186 |
| R-HSA-917937 | Iron uptake and transport | 0.651529 | 0.186 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.655938 | 0.183 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.655938 | 0.183 |
| R-HSA-5619084 | ABC transporter disorders | 0.664592 | 0.177 |
| R-HSA-4086400 | PCP/CE pathway | 0.664592 | 0.177 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.664592 | 0.177 |
| R-HSA-9609646 | HCMV Infection | 0.666491 | 0.176 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.668836 | 0.175 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.673028 | 0.172 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.673028 | 0.172 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.681253 | 0.167 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.685315 | 0.164 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.689273 | 0.162 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.693207 | 0.159 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.697091 | 0.157 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.697091 | 0.157 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.704714 | 0.152 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.704714 | 0.152 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.705765 | 0.151 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.708453 | 0.150 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.726456 | 0.139 |
| R-HSA-391251 | Protein folding | 0.726456 | 0.139 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.726549 | 0.139 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.736721 | 0.133 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.740057 | 0.131 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.743351 | 0.129 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.743351 | 0.129 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.743351 | 0.129 |
| R-HSA-1296071 | Potassium Channels | 0.743351 | 0.129 |
| R-HSA-190236 | Signaling by FGFR | 0.749815 | 0.125 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.751938 | 0.124 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.752986 | 0.123 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.756117 | 0.121 |
| R-HSA-9609690 | HCMV Early Events | 0.757679 | 0.121 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.759208 | 0.120 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.759208 | 0.120 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.762261 | 0.118 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.765269 | 0.116 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.766624 | 0.115 |
| R-HSA-195721 | Signaling by WNT | 0.768969 | 0.114 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.771189 | 0.113 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.771189 | 0.113 |
| R-HSA-9833110 | RSV-host interactions | 0.771189 | 0.113 |
| R-HSA-69239 | Synthesis of DNA | 0.779783 | 0.108 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.779783 | 0.108 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.779783 | 0.108 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.788056 | 0.103 |
| R-HSA-8978868 | Fatty acid metabolism | 0.793134 | 0.101 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.793749 | 0.100 |
| R-HSA-1280218 | Adaptive Immune System | 0.799173 | 0.097 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.803686 | 0.095 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.809567 | 0.092 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.811065 | 0.091 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.811065 | 0.091 |
| R-HSA-72766 | Translation | 0.823970 | 0.084 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.825006 | 0.084 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.827228 | 0.082 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.831587 | 0.080 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.831587 | 0.080 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.831587 | 0.080 |
| R-HSA-69206 | G1/S Transition | 0.831587 | 0.080 |
| R-HSA-8939211 | ESR-mediated signaling | 0.838207 | 0.077 |
| R-HSA-5576891 | Cardiac conduction | 0.846002 | 0.073 |
| R-HSA-2262752 | Cellular responses to stress | 0.853293 | 0.069 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.857375 | 0.067 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.857375 | 0.067 |
| R-HSA-5173105 | O-linked glycosylation | 0.859188 | 0.066 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.866016 | 0.062 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.872887 | 0.059 |
| R-HSA-416476 | G alpha (q) signalling events | 0.876363 | 0.057 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.877675 | 0.057 |
| R-HSA-69242 | S Phase | 0.879231 | 0.056 |
| R-HSA-168249 | Innate Immune System | 0.880790 | 0.055 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.883781 | 0.054 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.885260 | 0.053 |
| R-HSA-2142753 | Arachidonate metabolism | 0.885260 | 0.053 |
| R-HSA-9609507 | Protein localization | 0.886720 | 0.052 |
| R-HSA-69306 | DNA Replication | 0.886720 | 0.052 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.888028 | 0.052 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.888265 | 0.051 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.893746 | 0.049 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.894768 | 0.048 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.911195 | 0.040 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.912327 | 0.040 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.921178 | 0.036 |
| R-HSA-3781865 | Diseases of glycosylation | 0.924833 | 0.034 |
| R-HSA-5663205 | Infectious disease | 0.925219 | 0.034 |
| R-HSA-392499 | Metabolism of proteins | 0.926790 | 0.033 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.932692 | 0.030 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.938789 | 0.027 |
| R-HSA-428157 | Sphingolipid metabolism | 0.939570 | 0.027 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.940341 | 0.027 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.941103 | 0.026 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.941103 | 0.026 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.941969 | 0.026 |
| R-HSA-6805567 | Keratinization | 0.944053 | 0.025 |
| R-HSA-1643685 | Disease | 0.947579 | 0.023 |
| R-HSA-9748784 | Drug ADME | 0.952050 | 0.021 |
| R-HSA-8951664 | Neddylation | 0.953865 | 0.021 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.956013 | 0.020 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.958908 | 0.018 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.962449 | 0.017 |
| R-HSA-157118 | Signaling by NOTCH | 0.963872 | 0.016 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.974816 | 0.011 |
| R-HSA-109582 | Hemostasis | 0.976845 | 0.010 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.978978 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 0.986430 | 0.006 |
| R-HSA-8957322 | Metabolism of steroids | 0.987786 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.988418 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 0.988844 | 0.005 |
| R-HSA-388396 | GPCR downstream signalling | 0.991412 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.992727 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.995324 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.996237 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 0.996836 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998957 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999990 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1E |
0.745 | 0.343 | -3 | 0.730 |
CK1D |
0.744 | 0.363 | -3 | 0.731 |
GRK1 |
0.742 | 0.196 | -2 | 0.841 |
CK1A2 |
0.740 | 0.347 | -3 | 0.722 |
COT |
0.736 | 0.178 | 2 | 0.647 |
CK1G1 |
0.731 | 0.299 | -3 | 0.715 |
CDC7 |
0.731 | 0.164 | 1 | 0.796 |
KIS |
0.730 | 0.118 | 1 | 0.598 |
MOS |
0.729 | 0.199 | 1 | 0.783 |
CK1A |
0.728 | 0.308 | -3 | 0.718 |
BMPR1B |
0.724 | 0.191 | 1 | 0.822 |
IKKB |
0.721 | 0.101 | -2 | 0.754 |
GRK7 |
0.719 | 0.154 | 1 | 0.708 |
CLK3 |
0.718 | 0.062 | 1 | 0.726 |
IKKA |
0.716 | 0.080 | -2 | 0.757 |
GRK6 |
0.716 | 0.134 | 1 | 0.801 |
GRK5 |
0.715 | 0.154 | -3 | 0.537 |
MTOR |
0.713 | 0.019 | 1 | 0.703 |
PIM3 |
0.713 | 0.039 | -3 | 0.395 |
GRK4 |
0.712 | 0.125 | -2 | 0.855 |
RAF1 |
0.711 | 0.045 | 1 | 0.793 |
DSTYK |
0.711 | 0.041 | 2 | 0.653 |
IKKE |
0.709 | 0.031 | 1 | 0.713 |
TBK1 |
0.709 | 0.022 | 1 | 0.707 |
PRPK |
0.708 | -0.033 | -1 | 0.809 |
NDR2 |
0.707 | 0.001 | -3 | 0.391 |
HIPK4 |
0.706 | 0.067 | 1 | 0.675 |
ACVR2B |
0.706 | 0.147 | -2 | 0.799 |
CHAK2 |
0.706 | 0.105 | -1 | 0.791 |
GSK3A |
0.706 | -0.002 | 4 | 0.075 |
BMPR1A |
0.706 | 0.134 | 1 | 0.802 |
GRK2 |
0.705 | 0.116 | -2 | 0.762 |
CAMK2G |
0.705 | -0.040 | 2 | 0.595 |
GRK3 |
0.705 | 0.136 | -2 | 0.733 |
ATR |
0.704 | 0.015 | 1 | 0.694 |
SKMLCK |
0.704 | 0.035 | -2 | 0.855 |
RIPK3 |
0.704 | 0.029 | 3 | 0.701 |
GSK3B |
0.703 | -0.013 | 4 | 0.079 |
TGFBR1 |
0.702 | 0.080 | -2 | 0.821 |
BMPR2 |
0.702 | 0.026 | -2 | 0.873 |
ACVR2A |
0.702 | 0.133 | -2 | 0.784 |
MLK1 |
0.701 | 0.020 | 2 | 0.599 |
NLK |
0.701 | -0.016 | 1 | 0.737 |
ALK4 |
0.700 | 0.107 | -2 | 0.843 |
TGFBR2 |
0.699 | 0.024 | -2 | 0.796 |
PDHK4 |
0.699 | -0.114 | 1 | 0.769 |
ERK5 |
0.699 | -0.008 | 1 | 0.695 |
CDKL1 |
0.698 | -0.025 | -3 | 0.367 |
SRPK1 |
0.698 | 0.004 | -3 | 0.336 |
RSK2 |
0.697 | -0.004 | -3 | 0.319 |
GCN2 |
0.697 | -0.096 | 2 | 0.591 |
CDK1 |
0.697 | 0.043 | 1 | 0.573 |
FAM20C |
0.697 | -0.015 | 2 | 0.418 |
DLK |
0.697 | 0.053 | 1 | 0.767 |
NEK6 |
0.697 | -0.010 | -2 | 0.846 |
CK1G3 |
0.695 | 0.275 | -3 | 0.701 |
MLK3 |
0.695 | 0.040 | 2 | 0.550 |
CAMK1B |
0.695 | -0.053 | -3 | 0.397 |
RSK4 |
0.695 | 0.017 | -3 | 0.319 |
NEK7 |
0.695 | -0.055 | -3 | 0.446 |
MST4 |
0.695 | -0.018 | 2 | 0.672 |
ULK2 |
0.694 | -0.084 | 2 | 0.584 |
PDHK1 |
0.694 | -0.094 | 1 | 0.766 |
PRKD1 |
0.693 | 0.008 | -3 | 0.333 |
PIM1 |
0.693 | 0.004 | -3 | 0.367 |
MLK4 |
0.693 | 0.062 | 2 | 0.523 |
PLK1 |
0.693 | 0.015 | -2 | 0.780 |
BCKDK |
0.693 | -0.052 | -1 | 0.729 |
CK1G2 |
0.693 | 0.243 | -3 | 0.713 |
TTBK2 |
0.693 | 0.006 | 2 | 0.505 |
CDKL5 |
0.693 | -0.016 | -3 | 0.350 |
DAPK2 |
0.692 | -0.014 | -3 | 0.399 |
ANKRD3 |
0.692 | 0.022 | 1 | 0.770 |
PASK |
0.692 | 0.083 | -3 | 0.425 |
ALK2 |
0.691 | 0.058 | -2 | 0.830 |
TLK2 |
0.691 | 0.084 | 1 | 0.692 |
ICK |
0.691 | 0.007 | -3 | 0.383 |
PKN3 |
0.691 | -0.042 | -3 | 0.367 |
PKN2 |
0.691 | -0.033 | -3 | 0.384 |
NDR1 |
0.690 | -0.037 | -3 | 0.372 |
ULK1 |
0.690 | -0.080 | -3 | 0.419 |
CK2A2 |
0.690 | 0.052 | 1 | 0.726 |
P90RSK |
0.690 | -0.025 | -3 | 0.325 |
MASTL |
0.690 | -0.047 | -2 | 0.801 |
CAMLCK |
0.690 | -0.026 | -2 | 0.828 |
CAMK2B |
0.689 | -0.027 | 2 | 0.562 |
AURC |
0.689 | 0.037 | -2 | 0.628 |
CK2A1 |
0.689 | 0.056 | 1 | 0.715 |
NIK |
0.688 | -0.043 | -3 | 0.419 |
CDK8 |
0.688 | -0.001 | 1 | 0.584 |
CAMK2A |
0.688 | -0.021 | 2 | 0.592 |
JNK2 |
0.688 | 0.046 | 1 | 0.558 |
CLK2 |
0.687 | 0.001 | -3 | 0.327 |
JNK3 |
0.687 | 0.031 | 1 | 0.575 |
MLK2 |
0.687 | 0.030 | 2 | 0.624 |
SRPK2 |
0.687 | -0.020 | -3 | 0.287 |
HIPK2 |
0.687 | 0.029 | 1 | 0.532 |
DYRK2 |
0.687 | -0.004 | 1 | 0.612 |
PKACG |
0.686 | -0.012 | -2 | 0.705 |
LATS2 |
0.686 | -0.032 | -5 | 0.766 |
CDK18 |
0.686 | 0.017 | 1 | 0.524 |
CDK19 |
0.686 | 0.013 | 1 | 0.552 |
YSK4 |
0.686 | 0.028 | 1 | 0.724 |
P70S6KB |
0.686 | -0.035 | -3 | 0.340 |
CAMK2D |
0.686 | -0.033 | -3 | 0.361 |
SRPK3 |
0.685 | -0.022 | -3 | 0.340 |
ATM |
0.685 | -0.040 | 1 | 0.639 |
YANK3 |
0.685 | 0.085 | 2 | 0.310 |
PRKD2 |
0.685 | -0.010 | -3 | 0.294 |
PKCD |
0.685 | -0.010 | 2 | 0.590 |
LATS1 |
0.685 | -0.017 | -3 | 0.384 |
RSK3 |
0.685 | -0.038 | -3 | 0.304 |
HUNK |
0.685 | -0.136 | 2 | 0.605 |
MAPKAPK2 |
0.684 | -0.008 | -3 | 0.286 |
MEK1 |
0.684 | 0.041 | 2 | 0.652 |
RIPK1 |
0.684 | -0.057 | 1 | 0.714 |
WNK1 |
0.684 | -0.081 | -2 | 0.869 |
MEKK3 |
0.684 | 0.061 | 1 | 0.742 |
CDK7 |
0.683 | 0.012 | 1 | 0.591 |
MSK1 |
0.683 | -0.016 | -3 | 0.315 |
PRKX |
0.683 | 0.008 | -3 | 0.281 |
PKACB |
0.682 | 0.016 | -2 | 0.636 |
P38B |
0.682 | 0.029 | 1 | 0.554 |
MARK4 |
0.681 | -0.115 | 4 | 0.137 |
NUAK2 |
0.681 | -0.096 | -3 | 0.381 |
PKCA |
0.681 | -0.006 | 2 | 0.545 |
ERK1 |
0.680 | 0.012 | 1 | 0.547 |
SMG1 |
0.680 | -0.013 | 1 | 0.632 |
DRAK1 |
0.680 | -0.010 | 1 | 0.784 |
CDK17 |
0.680 | 0.009 | 1 | 0.490 |
P38G |
0.680 | 0.019 | 1 | 0.487 |
PRP4 |
0.680 | -0.010 | -3 | 0.408 |
PKCG |
0.679 | -0.024 | 2 | 0.546 |
AMPKA1 |
0.679 | -0.076 | -3 | 0.382 |
HIPK1 |
0.679 | 0.013 | 1 | 0.623 |
IRE1 |
0.679 | -0.078 | 1 | 0.669 |
PLK3 |
0.679 | -0.057 | 2 | 0.569 |
NEK9 |
0.679 | -0.104 | 2 | 0.619 |
PLK2 |
0.678 | -0.006 | -3 | 0.426 |
MST3 |
0.678 | 0.046 | 2 | 0.653 |
MYLK4 |
0.678 | -0.014 | -2 | 0.744 |
CLK4 |
0.678 | -0.026 | -3 | 0.341 |
TLK1 |
0.677 | 0.052 | -2 | 0.844 |
PAK1 |
0.677 | -0.031 | -2 | 0.766 |
P38A |
0.677 | 0.007 | 1 | 0.611 |
PLK4 |
0.676 | -0.006 | 2 | 0.471 |
MSK2 |
0.676 | -0.060 | -3 | 0.328 |
P38D |
0.676 | 0.026 | 1 | 0.477 |
JNK1 |
0.676 | 0.025 | 1 | 0.545 |
VRK2 |
0.676 | -0.105 | 1 | 0.753 |
AURA |
0.676 | -0.006 | -2 | 0.606 |
WNK3 |
0.675 | -0.194 | 1 | 0.713 |
CDK5 |
0.675 | -0.015 | 1 | 0.601 |
AKT2 |
0.674 | -0.009 | -3 | 0.278 |
PKCB |
0.674 | -0.044 | 2 | 0.545 |
PKR |
0.674 | -0.078 | 1 | 0.733 |
MAPKAPK3 |
0.674 | -0.051 | -3 | 0.301 |
DYRK4 |
0.673 | -0.015 | 1 | 0.550 |
DNAPK |
0.673 | -0.035 | 1 | 0.608 |
AURB |
0.673 | -0.004 | -2 | 0.623 |
CDK13 |
0.673 | -0.022 | 1 | 0.564 |
MEKK2 |
0.673 | 0.049 | 2 | 0.594 |
CLK1 |
0.672 | -0.035 | -3 | 0.299 |
NEK11 |
0.672 | 0.026 | 1 | 0.749 |
CDK16 |
0.672 | 0.007 | 1 | 0.495 |
CHAK1 |
0.672 | -0.073 | 2 | 0.633 |
GAK |
0.672 | 0.056 | 1 | 0.744 |
QSK |
0.672 | -0.077 | 4 | 0.141 |
AMPKA2 |
0.672 | -0.078 | -3 | 0.353 |
CAMK4 |
0.672 | -0.077 | -3 | 0.368 |
ZAK |
0.672 | -0.013 | 1 | 0.719 |
PHKG1 |
0.672 | -0.053 | -3 | 0.369 |
CDK3 |
0.672 | 0.006 | 1 | 0.506 |
PAK3 |
0.671 | -0.046 | -2 | 0.753 |
PKG2 |
0.671 | -0.010 | -2 | 0.634 |
IRE2 |
0.671 | -0.071 | 2 | 0.552 |
TAO3 |
0.671 | 0.013 | 1 | 0.726 |
DYRK1A |
0.671 | -0.027 | 1 | 0.631 |
BRAF |
0.671 | 0.005 | -4 | 0.790 |
CDK14 |
0.670 | 0.002 | 1 | 0.574 |
PAK2 |
0.670 | -0.035 | -2 | 0.747 |
GCK |
0.670 | 0.076 | 1 | 0.786 |
MEK5 |
0.670 | -0.041 | 2 | 0.629 |
TTBK1 |
0.670 | -0.030 | 2 | 0.449 |
SGK3 |
0.670 | -0.030 | -3 | 0.310 |
MPSK1 |
0.669 | 0.030 | 1 | 0.670 |
ERK2 |
0.669 | -0.026 | 1 | 0.574 |
TSSK2 |
0.668 | -0.102 | -5 | 0.779 |
MARK3 |
0.668 | -0.099 | 4 | 0.102 |
PIM2 |
0.668 | -0.021 | -3 | 0.304 |
CDK2 |
0.668 | -0.041 | 1 | 0.647 |
PKCH |
0.668 | -0.074 | 2 | 0.525 |
PKCZ |
0.668 | -0.062 | 2 | 0.582 |
NIM1 |
0.667 | -0.127 | 3 | 0.690 |
PAK6 |
0.667 | -0.010 | -2 | 0.670 |
PRKD3 |
0.666 | -0.053 | -3 | 0.286 |
NEK2 |
0.666 | -0.092 | 2 | 0.620 |
CDK12 |
0.666 | -0.026 | 1 | 0.543 |
MARK2 |
0.665 | -0.128 | 4 | 0.092 |
MST2 |
0.665 | 0.026 | 1 | 0.763 |
PINK1 |
0.665 | -0.084 | 1 | 0.706 |
TAK1 |
0.665 | 0.097 | 1 | 0.761 |
HIPK3 |
0.665 | -0.021 | 1 | 0.614 |
TSSK1 |
0.664 | -0.114 | -3 | 0.384 |
NEK5 |
0.664 | -0.038 | 1 | 0.711 |
SIK |
0.664 | -0.096 | -3 | 0.318 |
MEKK1 |
0.664 | -0.087 | 1 | 0.720 |
CDK10 |
0.664 | -0.003 | 1 | 0.562 |
BRSK1 |
0.664 | -0.109 | -3 | 0.326 |
YANK2 |
0.664 | 0.096 | 2 | 0.311 |
DYRK1B |
0.664 | -0.022 | 1 | 0.575 |
NUAK1 |
0.663 | -0.109 | -3 | 0.323 |
MNK1 |
0.663 | -0.060 | -2 | 0.758 |
PERK |
0.662 | -0.062 | -2 | 0.824 |
MAK |
0.662 | 0.038 | -2 | 0.810 |
MNK2 |
0.661 | -0.070 | -2 | 0.752 |
LKB1 |
0.661 | 0.066 | -3 | 0.409 |
DAPK1 |
0.661 | -0.015 | -3 | 0.362 |
QIK |
0.661 | -0.154 | -3 | 0.372 |
AKT3 |
0.661 | 0.031 | -3 | 0.240 |
PKACA |
0.661 | -0.018 | -2 | 0.581 |
HPK1 |
0.661 | 0.053 | 1 | 0.782 |
DYRK3 |
0.659 | -0.037 | 1 | 0.626 |
SMMLCK |
0.659 | -0.061 | -3 | 0.360 |
BRSK2 |
0.659 | -0.131 | -3 | 0.338 |
CAMK1G |
0.659 | -0.100 | -3 | 0.323 |
DAPK3 |
0.659 | -0.031 | -3 | 0.358 |
AKT1 |
0.658 | -0.021 | -3 | 0.281 |
SNRK |
0.658 | -0.139 | 2 | 0.518 |
CDK9 |
0.658 | -0.049 | 1 | 0.572 |
MELK |
0.658 | -0.109 | -3 | 0.326 |
MINK |
0.658 | 0.022 | 1 | 0.752 |
NEK8 |
0.658 | -0.037 | 2 | 0.613 |
P70S6K |
0.657 | -0.055 | -3 | 0.273 |
DCAMKL1 |
0.657 | -0.083 | -3 | 0.319 |
IRAK4 |
0.657 | -0.099 | 1 | 0.674 |
PDK1 |
0.656 | -0.018 | 1 | 0.718 |
MARK1 |
0.656 | -0.135 | 4 | 0.107 |
MAPKAPK5 |
0.656 | -0.105 | -3 | 0.285 |
CAMKK1 |
0.655 | -0.055 | -2 | 0.736 |
HRI |
0.655 | -0.143 | -2 | 0.829 |
MAP3K15 |
0.655 | -0.028 | 1 | 0.691 |
CAMKK2 |
0.655 | -0.003 | -2 | 0.730 |
SGK1 |
0.654 | -0.025 | -3 | 0.232 |
KHS2 |
0.653 | 0.046 | 1 | 0.773 |
EEF2K |
0.653 | -0.038 | 3 | 0.727 |
MST1 |
0.653 | 0.000 | 1 | 0.743 |
SLK |
0.652 | 0.014 | -2 | 0.690 |
PKCT |
0.652 | -0.074 | 2 | 0.535 |
PKCE |
0.652 | -0.052 | 2 | 0.538 |
ERK7 |
0.652 | -0.030 | 2 | 0.389 |
DCAMKL2 |
0.652 | -0.083 | -3 | 0.327 |
TNIK |
0.652 | 0.009 | 3 | 0.740 |
KHS1 |
0.651 | 0.029 | 1 | 0.749 |
CHK1 |
0.650 | -0.088 | -3 | 0.319 |
NEK4 |
0.650 | -0.039 | 1 | 0.711 |
HGK |
0.650 | -0.015 | 3 | 0.754 |
STK33 |
0.649 | -0.051 | 2 | 0.466 |
TAO2 |
0.649 | -0.098 | 2 | 0.644 |
ALPHAK3 |
0.649 | 0.065 | -1 | 0.747 |
PAK4 |
0.649 | -0.012 | -2 | 0.621 |
TTK |
0.649 | 0.030 | -2 | 0.811 |
SSTK |
0.649 | -0.112 | 4 | 0.135 |
WNK4 |
0.648 | -0.154 | -2 | 0.861 |
PAK5 |
0.648 | -0.028 | -2 | 0.611 |
IRAK1 |
0.648 | -0.146 | -1 | 0.669 |
PKCI |
0.647 | -0.077 | 2 | 0.555 |
OSR1 |
0.647 | 0.030 | 2 | 0.618 |
MEKK6 |
0.646 | -0.101 | 1 | 0.695 |
BMPR2_TYR |
0.646 | 0.124 | -1 | 0.873 |
PHKG2 |
0.646 | -0.138 | -3 | 0.330 |
PDHK1_TYR |
0.645 | 0.178 | -1 | 0.857 |
PDHK3_TYR |
0.645 | 0.112 | 4 | 0.186 |
MRCKA |
0.644 | -0.032 | -3 | 0.310 |
MAP2K6_TYR |
0.644 | 0.167 | -1 | 0.830 |
PDHK4_TYR |
0.644 | 0.137 | 2 | 0.694 |
CDK6 |
0.644 | -0.031 | 1 | 0.545 |
ROCK2 |
0.643 | -0.020 | -3 | 0.337 |
TXK |
0.643 | 0.167 | 1 | 0.795 |
LOK |
0.643 | -0.022 | -2 | 0.726 |
MOK |
0.643 | -0.009 | 1 | 0.617 |
CAMK1D |
0.643 | -0.086 | -3 | 0.255 |
MRCKB |
0.642 | -0.031 | -3 | 0.299 |
CHK2 |
0.642 | -0.066 | -3 | 0.227 |
PBK |
0.642 | 0.017 | 1 | 0.654 |
VRK1 |
0.641 | -0.146 | 2 | 0.626 |
LRRK2 |
0.640 | -0.135 | 2 | 0.640 |
MAP2K4_TYR |
0.640 | 0.162 | -1 | 0.817 |
EPHA6 |
0.637 | 0.070 | -1 | 0.867 |
PKN1 |
0.637 | -0.073 | -3 | 0.276 |
NEK1 |
0.637 | -0.101 | 1 | 0.693 |
PTK2 |
0.637 | 0.125 | -1 | 0.870 |
DMPK1 |
0.636 | -0.023 | -3 | 0.320 |
YSK1 |
0.636 | -0.072 | 2 | 0.609 |
RIPK2 |
0.636 | -0.149 | 1 | 0.686 |
MEK2 |
0.635 | -0.138 | 2 | 0.623 |
CDK4 |
0.635 | -0.046 | 1 | 0.528 |
SYK |
0.635 | 0.145 | -1 | 0.834 |
BUB1 |
0.634 | -0.019 | -5 | 0.729 |
FYN |
0.634 | 0.091 | -1 | 0.867 |
EPHB4 |
0.633 | 0.055 | -1 | 0.810 |
LCK |
0.633 | 0.095 | -1 | 0.856 |
TESK1_TYR |
0.633 | 0.052 | 3 | 0.785 |
FGR |
0.633 | 0.098 | 1 | 0.747 |
EPHA4 |
0.631 | 0.026 | 2 | 0.590 |
HASPIN |
0.631 | -0.038 | -1 | 0.615 |
CRIK |
0.630 | -0.017 | -3 | 0.276 |
BLK |
0.630 | 0.065 | -1 | 0.850 |
MAP2K7_TYR |
0.630 | -0.044 | 2 | 0.660 |
MYO3A |
0.629 | -0.037 | 1 | 0.718 |
CAMK1A |
0.629 | -0.079 | -3 | 0.238 |
SBK |
0.628 | -0.050 | -3 | 0.188 |
PKMYT1_TYR |
0.628 | -0.051 | 3 | 0.764 |
MET |
0.628 | 0.077 | 3 | 0.711 |
SRMS |
0.627 | 0.041 | 1 | 0.782 |
EPHB1 |
0.627 | 0.042 | 1 | 0.775 |
ASK1 |
0.627 | -0.073 | 1 | 0.682 |
HCK |
0.626 | 0.028 | -1 | 0.834 |
FER |
0.626 | -0.002 | 1 | 0.769 |
PKG1 |
0.625 | -0.056 | -2 | 0.543 |
MYO3B |
0.625 | -0.059 | 2 | 0.644 |
YES1 |
0.624 | -0.014 | -1 | 0.818 |
EPHB2 |
0.624 | 0.026 | -1 | 0.798 |
BMX |
0.624 | 0.043 | -1 | 0.719 |
INSRR |
0.624 | 0.011 | 3 | 0.688 |
ROCK1 |
0.624 | -0.058 | -3 | 0.310 |
KIT |
0.624 | 0.032 | 3 | 0.722 |
STLK3 |
0.624 | -0.041 | 1 | 0.684 |
FLT1 |
0.623 | 0.088 | -1 | 0.829 |
EPHA7 |
0.623 | 0.037 | 2 | 0.583 |
CSF1R |
0.623 | -0.006 | 3 | 0.706 |
EPHB3 |
0.623 | 0.046 | -1 | 0.795 |
ABL2 |
0.622 | 0.018 | -1 | 0.762 |
ITK |
0.622 | 0.011 | -1 | 0.776 |
RET |
0.622 | -0.016 | 1 | 0.693 |
NEK3 |
0.622 | -0.112 | 1 | 0.655 |
PINK1_TYR |
0.621 | -0.119 | 1 | 0.728 |
JAK3 |
0.621 | 0.008 | 1 | 0.674 |
MST1R |
0.620 | -0.037 | 3 | 0.722 |
ERBB4 |
0.620 | 0.086 | 1 | 0.642 |
KDR |
0.620 | 0.035 | 3 | 0.690 |
LIMK2_TYR |
0.620 | -0.010 | -3 | 0.407 |
ROS1 |
0.620 | -0.038 | 3 | 0.677 |
ZAP70 |
0.619 | 0.145 | -1 | 0.750 |
ERBB2 |
0.619 | 0.028 | 1 | 0.682 |
EPHA8 |
0.619 | 0.043 | -1 | 0.817 |
ABL1 |
0.618 | -0.001 | -1 | 0.752 |
TYRO3 |
0.618 | -0.040 | 3 | 0.701 |
EPHA3 |
0.618 | -0.005 | 2 | 0.563 |
LYN |
0.618 | 0.030 | 3 | 0.643 |
TNK2 |
0.618 | 0.033 | 3 | 0.712 |
SRC |
0.618 | 0.031 | -1 | 0.829 |
JAK2 |
0.617 | -0.036 | 1 | 0.690 |
BIKE |
0.616 | -0.042 | 1 | 0.627 |
FGFR2 |
0.616 | -0.024 | 3 | 0.755 |
MERTK |
0.616 | 0.008 | 3 | 0.703 |
TEC |
0.615 | -0.015 | -1 | 0.699 |
TAO1 |
0.615 | -0.118 | 1 | 0.657 |
EPHA5 |
0.614 | 0.005 | 2 | 0.568 |
FRK |
0.614 | 0.003 | -1 | 0.823 |
DDR1 |
0.613 | -0.150 | 4 | 0.142 |
TYK2 |
0.613 | -0.117 | 1 | 0.692 |
FGFR3 |
0.613 | 0.003 | 3 | 0.730 |
EPHA2 |
0.612 | 0.037 | -1 | 0.790 |
EGFR |
0.611 | 0.009 | 1 | 0.593 |
FGFR4 |
0.611 | 0.035 | -1 | 0.737 |
PTK2B |
0.611 | 0.003 | -1 | 0.731 |
JAK1 |
0.611 | -0.009 | 1 | 0.665 |
TEK |
0.610 | -0.030 | 3 | 0.674 |
NTRK3 |
0.609 | 0.020 | -1 | 0.730 |
MATK |
0.609 | 0.009 | -1 | 0.688 |
LIMK1_TYR |
0.609 | -0.191 | 2 | 0.651 |
FLT3 |
0.609 | -0.081 | 3 | 0.698 |
NTRK1 |
0.608 | -0.053 | -1 | 0.772 |
ALK |
0.608 | -0.048 | 3 | 0.649 |
AXL |
0.607 | -0.034 | 3 | 0.715 |
FGFR1 |
0.607 | -0.040 | 3 | 0.703 |
PTK6 |
0.606 | -0.036 | -1 | 0.677 |
PDGFRB |
0.605 | -0.100 | 3 | 0.719 |
BTK |
0.605 | -0.104 | -1 | 0.719 |
EPHA1 |
0.605 | -0.034 | 3 | 0.696 |
INSR |
0.603 | -0.067 | 3 | 0.656 |
WEE1_TYR |
0.603 | -0.066 | -1 | 0.697 |
FLT4 |
0.603 | -0.048 | 3 | 0.694 |
LTK |
0.601 | -0.074 | 3 | 0.670 |
NTRK2 |
0.601 | -0.074 | 3 | 0.688 |
NEK10_TYR |
0.600 | -0.050 | 1 | 0.593 |
IGF1R |
0.600 | -0.031 | 3 | 0.610 |
FES |
0.600 | 0.007 | -1 | 0.692 |
TNNI3K_TYR |
0.600 | -0.059 | 1 | 0.697 |
CSK |
0.599 | -0.040 | 2 | 0.583 |
PDGFRA |
0.599 | -0.102 | 3 | 0.711 |
TNK1 |
0.597 | -0.094 | 3 | 0.681 |
AAK1 |
0.597 | -0.023 | 1 | 0.530 |
DDR2 |
0.596 | -0.119 | 3 | 0.699 |
MUSK |
0.578 | -0.095 | 1 | 0.571 |