Motif 490 (n=223)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQJ8 | ATRIP | S34 | ochoa | ATR interacting protein | None |
| A1A4S6 | ARHGAP10 | S640 | ochoa | Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) | GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}. |
| A4D1S0 | KLRG2 | S140 | ochoa | Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) | None |
| A4FU01 | MTMR11 | S175 | ochoa | Myotubularin-related protein 11 (Cisplatin resistance-associated protein) (hCRA) (Inactive phosphatidylinositol 3-phosphatase 11) | None |
| A5YKK6 | CNOT1 | S1008 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| A8CG34 | POM121C | S325 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| B8ZZF3 | None | S304 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| E9PAV3 | NACA | S1710 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00221 | NFKBIE | S180 | ochoa | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}. |
| O00512 | BCL9 | S154 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14777 | NDC80 | S66 | ochoa | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15117 | FYB1 | S388 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15417 | TNRC18 | S2372 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43399 | TPD52L2 | S186 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43474 | KLF4 | S246 | ochoa | Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}. |
| O43474 | KLF4 | S251 | ochoa | Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}. |
| O43474 | KLF4 | S313 | ochoa | Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}. |
| O60292 | SIPA1L3 | S1383 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60346 | PHLPP1 | S321 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60732 | MAGEC1 | S99 | ochoa | Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen) | None |
| O75128 | COBL | S284 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75152 | ZC3H11A | S129 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75376 | NCOR1 | Y1753 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75533 | SF3B1 | S308 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75674 | TOM1L1 | S308 | ochoa | TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) | Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}. |
| O75886 | STAM2 | S372 | ochoa | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
| O75925 | PIAS1 | S485 | ochoa | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O95402 | MED26 | S296 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95429 | BAG4 | S176 | ochoa | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| O95685 | PPP1R3D | S25 | ochoa | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. |
| O95835 | LATS1 | S218 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P00533 | EGFR | S1104 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P06748 | NPM1 | S214 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P0CG12 | DERPC | S293 | ochoa | Decreased expression in renal and prostate cancer protein | Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}. |
| P11137 | MAP2 | S626 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11362 | FGFR1 | S786 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P11388 | TOP2A | S1449 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12270 | TPR | S637 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P15822 | HIVEP1 | S2350 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P17936 | IGFBP3 | S148 | ochoa | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}. |
| P18206 | VCL | S272 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18848 | ATF4 | S245 | psp | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) | Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:16682973, PubMed:17684156, PubMed:31023583, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:31023583, PubMed:32132707). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:31023583, PubMed:32132706, PubMed:32132707). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (PubMed:26086088). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:11960987). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (PubMed:18940792). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Activates the expression of COX7A2L/SCAF1 downstream of the EIF2AK3/PERK-mediated unfolded protein response, thereby promoting formation of respiratory chain supercomplexes and increasing mitochondrial oxidative phosphorylation (PubMed:31023583). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (PubMed:33384352). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). {ECO:0000250|UniProtKB:Q06507, ECO:0000269|PubMed:11960987, ECO:0000269|PubMed:15109498, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17684156, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:31444471, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:33384352}.; FUNCTION: (Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. {ECO:0000269|PubMed:1847461}. |
| P18887 | XRCC1 | S223 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19634 | SLC9A1 | S602 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P24864 | CCNE1 | S100 | ochoa | G1/S-specific cyclin-E1 | Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}. |
| P27816 | MAP4 | S876 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27987 | ITPKB | S31 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P27987 | ITPKB | S352 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P30203 | CD6 | S562 | psp | T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}. |
| P30260 | CDC27 | S352 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P30556 | AGTR1 | S335 | psp | Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor) | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, PubMed:8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106). {ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:1567413, ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0000269|PubMed:8987975}.; FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. {ECO:0000269|PubMed:33713620}. |
| P30622 | CLIP1 | S155 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P33240 | CSTF2 | S310 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P42684 | ABL2 | S602 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46013 | MKI67 | S1115 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1736 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48436 | SOX9 | S228 | ochoa | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P48681 | NES | S320 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S680 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P51825 | AFF1 | S203 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P53396 | ACLY | S478 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P55198 | MLLT6 | S435 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
| P56693 | SOX10 | S27 | ochoa | Transcription factor SOX-10 | Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}. |
| P78369 | CLDN10 | S199 | ochoa | Claudin-10 (Oligodendrocyte-specific protein-like) (OSP-like) | Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}.; FUNCTION: [Isoform 1]: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28686597, PubMed:28771254, PubMed:35650657, PubMed:36008380). {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}.; FUNCTION: [Isoform 2]: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis. {ECO:0000250|UniProtKB:Q9Z0S6, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:36008380}. |
| P78524 | DENND2B | S522 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78559 | MAP1A | S1200 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P81133 | SIM1 | S382 | ochoa | Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) | Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. |
| P85037 | FOXK1 | S236 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P85299 | PRR5 | S284 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| Q01664 | TFAP4 | S121 | ochoa | Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41) | Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. |
| Q02224 | CENPE | S2651 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q03164 | KMT2A | S3050 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q08174 | PCDH1 | S1011 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q08174 | PCDH1 | S1018 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q09666 | AHNAK | S4900 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12830 | BPTF | S198 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12888 | TP53BP1 | S1317 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13283 | G3BP1 | S253 | ochoa | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q13409 | DYNC1I2 | S101 | ochoa | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}. |
| Q13425 | SNTB2 | S228 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Q14004 | CDK13 | S337 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14687 | GSE1 | S81 | ochoa | Genetic suppressor element 1 | None |
| Q14694 | USP10 | S352 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14764 | MVP | S864 | ochoa|psp | Major vault protein (MVP) (Lung resistance-related protein) | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}. |
| Q14934 | NFATC4 | S278 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14980 | NUMA1 | S1942 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15172 | PPP2R5A | S38 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q15722 | LTB4R | S310 | ochoa|psp | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Q15788 | NCOA1 | S369 | ochoa | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q2LD37 | BLTP1 | S1287 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q5FWE3 | PRRT3 | S925 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JSZ5 | PRRC2B | S1231 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5M775 | SPECC1 | S131 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SW79 | CEP170 | S1076 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T011 | SZT2 | S718 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T1R4 | HIVEP3 | S2006 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5TCZ1 | SH3PXD2A | S639 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5TCZ1 | SH3PXD2A | S1038 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VT52 | RPRD2 | S1185 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VZ89 | DENND4C | S1659 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HK5 | TSHZ3 | S597 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q66K74 | MAP1S | S475 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6BDS2 | BLTP3A | S432 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6GQQ9 | OTUD7B | S60 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6N022 | TENM4 | S209 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6N043 | ZNF280D | S527 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6P0N0 | MIS18BP1 | S131 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P2E9 | EDC4 | S768 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PJ61 | FBXO46 | S21 | psp | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6Q6R5 | CRIP3 | S93 | ochoa | Cysteine-rich protein 3 (CRP-3) (Chromosome 6 LIM domain only protein) (h6LIMo) | None |
| Q6T4R5 | NHS | S415 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UUV7 | CRTC3 | S169 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6UUV7 | CRTC3 | S370 | ochoa|psp | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6ZNB6 | NFXL1 | S47 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q6ZNC4 | ZNF704 | S332 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q6ZRI6 | C15orf39 | S455 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZRV2 | FAM83H | S523 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZW49 | PAXIP1 | S253 | ochoa | PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) | Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity). {ECO:0000250|UniProtKB:Q6NZQ4, ECO:0000269|PubMed:14576432, ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115, ECO:0000269|PubMed:17925232, ECO:0000269|PubMed:18353733, ECO:0000269|PubMed:20088963, ECO:0000269|PubMed:23727112}. |
| Q76L83 | ASXL2 | S842 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7L4E1 | MIGA2 | S203 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7L5Y9 | MAEA | S308 | ochoa | E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:9763581, ECO:0000305|PubMed:16510120}. |
| Q7Z589 | EMSY | S1210 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q7Z5L9 | IRF2BP2 | S396 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q86U70 | LDB1 | S305 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q86UU0 | BCL9L | S1051 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86X51 | EZHIP | S394 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86X51 | EZHIP | S447 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86YN6 | PPARGC1B | S381 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q86YP4 | GATAD2A | S182 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IUF8 | RIOX2 | S44 | ochoa | Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}. |
| Q8IVT5 | KSR1 | S267 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8N2Y8 | RUSC2 | S772 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8N5S9 | CAMKK1 | S82 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8N8K9 | KIAA1958 | S79 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NCG7 | DAGLB | S574 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
| Q8NI27 | THOC2 | S1390 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TAD8 | SNIP1 | S49 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TD16 | BICD2 | S605 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8WWI1 | LMO7 | S1570 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXE0 | CASKIN2 | S720 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WXE1 | ATRIP | S221 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WYL5 | SSH1 | S894 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q8WYP5 | AHCTF1 | S2209 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92585 | MAML1 | S335 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92622 | RUBCN | S413 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q92841 | DDX17 | S672 | ochoa | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}. |
| Q92934 | BAD | S71 | ochoa | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q92997 | DVL3 | S636 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q93052 | LPP | S148 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q96AY4 | TTC28 | S2224 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96D71 | REPS1 | S219 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96EZ8 | MCRS1 | S87 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
| Q96GM8 | TOE1 | S425 | ochoa | Target of EGR1 protein 1 | Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}. |
| Q96HA1 | POM121 | S348 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96PE2 | ARHGEF17 | S142 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96RN5 | MED15 | S502 | ochoa | Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}. |
| Q96T37 | RBM15 | S656 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96T58 | SPEN | S3463 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99081 | TCF12 | S160 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99569 | PKP4 | S1088 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99590 | SCAF11 | S335 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99640 | PKMYT1 | S479 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q9BQL6 | FERMT1 | S174 | ochoa|psp | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}. |
| Q9BRD0 | BUD13 | S308 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRK4 | LZTS2 | S224 | ochoa|psp | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BRR8 | GPATCH1 | S200 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BTA9 | WAC | S520 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BTV7 | CABLES2 | S269 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9BX63 | BRIP1 | S1029 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXF6 | RAB11FIP5 | S251 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BYB0 | SHANK3 | S1162 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZ29 | DOCK9 | S440 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C0B0 | UNK | S476 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0C2 | TNKS1BP1 | S984 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZV5 | WWTR1 | S87 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H792 | PEAK1 | S1148 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7P9 | PLEKHG2 | S49 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H9J4 | USP42 | S72 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HAW4 | CLSPN | S830 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HCU4 | CELSR2 | S2675 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NQ88 | TIGAR | S154 | ochoa | Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase) | Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:22887998, PubMed:23726973, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:16839880, ECO:0000269|PubMed:19015259, ECO:0000269|PubMed:19713938, ECO:0000269|PubMed:22887998, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:23817040, ECO:0000269|PubMed:25928429}. |
| Q9NQW6 | ANLN | S45 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQW6 | ANLN | S169 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRR3 | CDC42SE2 | S52 | ochoa | CDC42 small effector protein 2 (Small effector of CDC42 protein 2) | Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583}. |
| Q9NVM9 | INTS13 | S623 | ochoa | Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling (PubMed:23097494, PubMed:23904267). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (PubMed:23097494, PubMed:23904267). {ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142}. |
| Q9NWH9 | SLTM | S1011 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NY59 | SMPD3 | S298 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NYF8 | BCLAF1 | S282 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYV4 | CDK12 | S1072 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZ09 | UBAP1 | S250 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
| Q9NZ71 | RTEL1 | S300 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9NZJ0 | DTL | S426 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9NZM4 | BICRA | S752 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
| Q9NZN8 | CNOT2 | S108 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Q9P0K7 | RAI14 | S260 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0U4 | CXXC1 | S221 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P0V3 | SH3BP4 | S241 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P273 | TENM3 | S199 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P2F8 | SIPA1L2 | S1549 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9P2N2 | ARHGAP28 | S255 | ochoa | Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2N5 | RBM27 | S472 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UGH3 | SLC23A2 | S78 | ochoa | Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2) | Sodium/ascorbate cotransporter (PubMed:10471399, PubMed:10556521). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10471399). {ECO:0000269|PubMed:10471399, ECO:0000269|PubMed:10556521}. |
| Q9UGJ0 | PRKAG2 | S157 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
| Q9UGU0 | TCF20 | S541 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UJF2 | RASAL2 | S925 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9ULE6 | PALD1 | S34 | ochoa | Paladin | None |
| Q9ULJ7 | ANKRD50 | S1135 | ochoa | Ankyrin repeat domain-containing protein 50 | Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). |
| Q9ULL1 | PLEKHG1 | S1323 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULU4 | ZMYND8 | S457 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULU4 | ZMYND8 | S472 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UPN7 | PPP6R1 | S756 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| Q9UPU9 | SAMD4A | S419 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9Y2J2 | EPB41L3 | S957 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2J4 | AMOTL2 | S176 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y3Q8 | TSC22D4 | S142 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y450 | HBS1L | S215 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y4B5 | MTCL1 | S1302 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y6W5 | WASF2 | S293 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| P00540 | MOS | S25 | Sugiyama | Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos) | Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation. {ECO:0000269|PubMed:34779126, ECO:0000269|PubMed:34997960, ECO:0000269|PubMed:35670744}. |
| Q92630 | DYRK2 | S471 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q96PY6 | NEK1 | S285 | Sugiyama | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q13162 | PRDX4 | S65 | Sugiyama | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}. |
| Q9NR20 | DYRK4 | S498 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) | Possible non-essential role in spermiogenesis. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 0.000197 | 3.706 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.000266 | 3.576 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000588 | 3.231 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.000823 | 3.085 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.000894 | 3.049 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 0.002526 | 2.598 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.002526 | 2.598 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.003603 | 2.443 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.002793 | 2.554 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.002793 | 2.554 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.003265 | 2.486 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.001358 | 2.867 |
| R-HSA-2028269 | Signaling by Hippo | 0.004301 | 2.366 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.003556 | 2.449 |
| R-HSA-5693538 | Homology Directed Repair | 0.003540 | 2.451 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.002734 | 2.563 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.003969 | 2.401 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.003241 | 2.489 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.002684 | 2.571 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.004187 | 2.378 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.003574 | 2.447 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.002851 | 2.545 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.005271 | 2.278 |
| R-HSA-9843745 | Adipogenesis | 0.006273 | 2.202 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.006089 | 2.215 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.005851 | 2.233 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.007113 | 2.148 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.009219 | 2.035 |
| R-HSA-429947 | Deadenylation of mRNA | 0.010019 | 1.999 |
| R-HSA-73894 | DNA Repair | 0.010703 | 1.970 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.010854 | 1.964 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.011079 | 1.955 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.013280 | 1.877 |
| R-HSA-212436 | Generic Transcription Pathway | 0.013517 | 1.869 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.013945 | 1.856 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.015072 | 1.822 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.020670 | 1.685 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.016250 | 1.789 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.017457 | 1.758 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.017457 | 1.758 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.020018 | 1.699 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.020018 | 1.699 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.021372 | 1.670 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.021200 | 1.674 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.020670 | 1.685 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.018375 | 1.736 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.021372 | 1.670 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.020063 | 1.698 |
| R-HSA-1538133 | G0 and Early G1 | 0.018713 | 1.728 |
| R-HSA-5688426 | Deubiquitination | 0.020734 | 1.683 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.018177 | 1.740 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.024227 | 1.616 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.025014 | 1.602 |
| R-HSA-68882 | Mitotic Anaphase | 0.023694 | 1.625 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.024215 | 1.616 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.028767 | 1.541 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.027183 | 1.566 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.027278 | 1.564 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.028932 | 1.539 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.028877 | 1.539 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.030525 | 1.515 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.032221 | 1.492 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.030525 | 1.515 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.032221 | 1.492 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.032221 | 1.492 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.032221 | 1.492 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.030525 | 1.515 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.033084 | 1.480 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.033965 | 1.469 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.033965 | 1.469 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.070380 | 1.153 |
| R-HSA-8941237 | Invadopodia formation | 0.070380 | 1.153 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.083852 | 1.076 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.083852 | 1.076 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.097130 | 1.013 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.110217 | 0.958 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.110217 | 0.958 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.110217 | 0.958 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.110217 | 0.958 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.123114 | 0.910 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.123114 | 0.910 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.123114 | 0.910 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.135826 | 0.867 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.041621 | 1.381 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.148354 | 0.829 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.148354 | 0.829 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.160701 | 0.794 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.160701 | 0.794 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.059822 | 1.223 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.063738 | 1.196 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.184863 | 0.733 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.184863 | 0.733 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.184863 | 0.733 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.071819 | 1.144 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.196683 | 0.706 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.196683 | 0.706 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.075977 | 1.119 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.075977 | 1.119 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.208332 | 0.681 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.208332 | 0.681 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.219813 | 0.658 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.219813 | 0.658 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.093325 | 1.030 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.093325 | 1.030 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.231128 | 0.636 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.231128 | 0.636 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.242280 | 0.616 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.242280 | 0.616 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.242280 | 0.616 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.242280 | 0.616 |
| R-HSA-72187 | mRNA 3'-end processing | 0.058566 | 1.232 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.253271 | 0.596 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.253271 | 0.596 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.274778 | 0.561 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.285299 | 0.545 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.295669 | 0.529 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.295669 | 0.529 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.305888 | 0.514 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.305888 | 0.514 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.305888 | 0.514 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.305888 | 0.514 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.181567 | 0.741 |
| R-HSA-774815 | Nucleosome assembly | 0.181567 | 0.741 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.239926 | 0.620 |
| R-HSA-1989781 | PPARA activates gene expression | 0.111061 | 0.954 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.126009 | 0.900 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.115042 | 0.939 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.274778 | 0.561 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.274778 | 0.561 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.149963 | 0.824 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.149963 | 0.824 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.149963 | 0.824 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.285299 | 0.545 |
| R-HSA-182971 | EGFR downregulation | 0.102389 | 0.990 |
| R-HSA-177929 | Signaling by EGFR | 0.239926 | 0.620 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.045066 | 1.346 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.063738 | 1.196 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.242280 | 0.616 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.160913 | 0.793 |
| R-HSA-180292 | GAB1 signalosome | 0.285299 | 0.545 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.264103 | 0.578 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.305888 | 0.514 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.288312 | 0.540 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.038282 | 1.417 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.160701 | 0.794 |
| R-HSA-5673000 | RAF activation | 0.121185 | 0.917 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.264103 | 0.578 |
| R-HSA-381042 | PERK regulates gene expression | 0.126009 | 0.900 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.208332 | 0.681 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.084514 | 1.073 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.186791 | 0.729 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.186791 | 0.729 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.186791 | 0.729 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.067738 | 1.169 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.237759 | 0.624 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.239926 | 0.620 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.097130 | 1.013 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.208332 | 0.681 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.219813 | 0.658 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.097827 | 1.010 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.111682 | 0.952 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.253271 | 0.596 |
| R-HSA-9664420 | Killing mechanisms | 0.253271 | 0.596 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.135789 | 0.867 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.274778 | 0.561 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.160913 | 0.793 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.202585 | 0.693 |
| R-HSA-9609690 | HCMV Early Events | 0.097044 | 1.013 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.116409 | 0.934 |
| R-HSA-9711097 | Cellular response to starvation | 0.256637 | 0.591 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.234563 | 0.630 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.210126 | 0.678 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.234563 | 0.630 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.116409 | 0.934 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.042509 | 1.372 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.261425 | 0.583 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.261425 | 0.583 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.261425 | 0.583 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.261425 | 0.583 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.160701 | 0.794 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.097827 | 1.010 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.231128 | 0.636 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.121185 | 0.917 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.186791 | 0.729 |
| R-HSA-180786 | Extension of Telomeres | 0.256046 | 0.592 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.098024 | 1.009 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.123114 | 0.910 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.160701 | 0.794 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.172870 | 0.762 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.172870 | 0.762 |
| R-HSA-4839744 | Signaling by APC mutants | 0.184863 | 0.733 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.071819 | 1.144 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.196683 | 0.706 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.196683 | 0.706 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.219813 | 0.658 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.219813 | 0.658 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.093325 | 1.030 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.043403 | 1.362 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.121185 | 0.917 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.264103 | 0.578 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.264103 | 0.578 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.081190 | 1.090 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.223859 | 0.650 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.229207 | 0.640 |
| R-HSA-73886 | Chromosome Maintenance | 0.136754 | 0.864 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.195220 | 0.709 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.066351 | 1.178 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.152365 | 0.817 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.098024 | 1.009 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.093325 | 1.030 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.111682 | 0.952 |
| R-HSA-9909396 | Circadian clock | 0.172056 | 0.764 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.274778 | 0.561 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.234563 | 0.630 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.234248 | 0.630 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.110217 | 0.958 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.148354 | 0.829 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.196683 | 0.706 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.080210 | 1.096 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.231128 | 0.636 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.107008 | 0.971 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.107008 | 0.971 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.140741 | 0.852 |
| R-HSA-9707616 | Heme signaling | 0.083906 | 1.076 |
| R-HSA-9609646 | HCMV Infection | 0.102778 | 0.988 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.155820 | 0.807 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.083852 | 1.076 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.123114 | 0.910 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.045066 | 1.346 |
| R-HSA-426048 | Arachidonate production from DAG | 0.172870 | 0.762 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.184863 | 0.733 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.264103 | 0.578 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.264103 | 0.578 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.075874 | 1.120 |
| R-HSA-191859 | snRNP Assembly | 0.075874 | 1.120 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.081190 | 1.090 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.295669 | 0.529 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.295669 | 0.529 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.119347 | 0.923 |
| R-HSA-69481 | G2/M Checkpoints | 0.058584 | 1.232 |
| R-HSA-69239 | Synthesis of DNA | 0.252216 | 0.598 |
| R-HSA-68877 | Mitotic Prometaphase | 0.037403 | 1.427 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.168290 | 0.774 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.218522 | 0.661 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.197302 | 0.705 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.261425 | 0.583 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.148354 | 0.829 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.046965 | 1.328 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.062874 | 1.202 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.181665 | 0.741 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.126009 | 0.900 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.068204 | 1.166 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.141979 | 0.848 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.077495 | 1.111 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.186791 | 0.729 |
| R-HSA-5689603 | UCH proteinases | 0.125721 | 0.901 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.093596 | 1.029 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.111682 | 0.952 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.148354 | 0.829 |
| R-HSA-69091 | Polymerase switching | 0.208332 | 0.681 |
| R-HSA-69109 | Leading Strand Synthesis | 0.208332 | 0.681 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.208332 | 0.681 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.219813 | 0.658 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.253271 | 0.596 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.160913 | 0.793 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.172870 | 0.762 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.073276 | 1.135 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.219235 | 0.659 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.044341 | 1.353 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.293680 | 0.532 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.042509 | 1.372 |
| R-HSA-9610379 | HCMV Late Events | 0.253469 | 0.596 |
| R-HSA-68886 | M Phase | 0.035936 | 1.444 |
| R-HSA-73893 | DNA Damage Bypass | 0.051796 | 1.286 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.041421 | 1.383 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.110217 | 0.958 |
| R-HSA-391906 | Leukotriene receptors | 0.123114 | 0.910 |
| R-HSA-9613354 | Lipophagy | 0.160701 | 0.794 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.208332 | 0.681 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.208332 | 0.681 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.208332 | 0.681 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.219813 | 0.658 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.045432 | 1.343 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.121185 | 0.917 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.113098 | 0.947 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.089266 | 1.049 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.290313 | 0.537 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.051672 | 1.287 |
| R-HSA-8953854 | Metabolism of RNA | 0.187725 | 0.726 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.277563 | 0.557 |
| R-HSA-8848021 | Signaling by PTK6 | 0.277563 | 0.557 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.107008 | 0.971 |
| R-HSA-445144 | Signal transduction by L1 | 0.052256 | 1.282 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.239926 | 0.620 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.151505 | 0.820 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.266805 | 0.574 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.052256 | 1.282 |
| R-HSA-5578768 | Physiological factors | 0.231128 | 0.636 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.264103 | 0.578 |
| R-HSA-109704 | PI3K Cascade | 0.207883 | 0.682 |
| R-HSA-199991 | Membrane Trafficking | 0.273671 | 0.563 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.197302 | 0.705 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.070720 | 1.150 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.144622 | 0.840 |
| R-HSA-9675135 | Diseases of DNA repair | 0.186791 | 0.729 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.287498 | 0.541 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.172870 | 0.762 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.155820 | 0.807 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.045540 | 1.342 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.085036 | 1.070 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.109510 | 0.961 |
| R-HSA-162582 | Signal Transduction | 0.069411 | 1.159 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.242280 | 0.616 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.250669 | 0.601 |
| R-HSA-75893 | TNF signaling | 0.068204 | 1.166 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.116207 | 0.935 |
| R-HSA-1483166 | Synthesis of PA | 0.245295 | 0.610 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.169399 | 0.771 |
| R-HSA-4839726 | Chromatin organization | 0.101317 | 0.994 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.038282 | 1.417 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.067738 | 1.169 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.208332 | 0.681 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.274778 | 0.561 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.285299 | 0.545 |
| R-HSA-112399 | IRS-mediated signalling | 0.245295 | 0.610 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.131609 | 0.881 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.195197 | 0.710 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.231128 | 0.636 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.274778 | 0.561 |
| R-HSA-9629569 | Protein hydroxylation | 0.305888 | 0.514 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.085769 | 1.067 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.059822 | 1.223 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.092724 | 1.033 |
| R-HSA-68875 | Mitotic Prophase | 0.134172 | 0.872 |
| R-HSA-70171 | Glycolysis | 0.221450 | 0.655 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.111682 | 0.952 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.253271 | 0.596 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.305888 | 0.514 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.266805 | 0.574 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.207114 | 0.684 |
| R-HSA-73887 | Death Receptor Signaling | 0.041798 | 1.379 |
| R-HSA-162906 | HIV Infection | 0.293852 | 0.532 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.047886 | 1.320 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.130878 | 0.883 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.315088 | 0.502 |
| R-HSA-3371556 | Cellular response to heat stress | 0.136754 | 0.864 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.266805 | 0.574 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.285299 | 0.545 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.305888 | 0.514 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.207114 | 0.684 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.122518 | 0.912 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.253271 | 0.596 |
| R-HSA-5358508 | Mismatch Repair | 0.285299 | 0.545 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.282939 | 0.548 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.109096 | 0.962 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.288312 | 0.540 |
| R-HSA-162587 | HIV Life Cycle | 0.253469 | 0.596 |
| R-HSA-70326 | Glucose metabolism | 0.299355 | 0.524 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.282939 | 0.548 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.217658 | 0.662 |
| R-HSA-72306 | tRNA processing | 0.298453 | 0.525 |
| R-HSA-211000 | Gene Silencing by RNA | 0.252216 | 0.598 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.315960 | 0.500 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.315960 | 0.500 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.315960 | 0.500 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.315960 | 0.500 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.315960 | 0.500 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.315960 | 0.500 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.315960 | 0.500 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 0.315960 | 0.500 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.320420 | 0.494 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.320420 | 0.494 |
| R-HSA-195721 | Signaling by WNT | 0.320653 | 0.494 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.323136 | 0.491 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.325741 | 0.487 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.325886 | 0.487 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.325886 | 0.487 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.331052 | 0.480 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.335669 | 0.474 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.336350 | 0.473 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.341637 | 0.466 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.341637 | 0.466 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.343032 | 0.465 |
| R-HSA-200425 | Carnitine shuttle | 0.345311 | 0.462 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.345311 | 0.462 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.346910 | 0.460 |
| R-HSA-2262752 | Cellular responses to stress | 0.348791 | 0.457 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.352169 | 0.453 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.354813 | 0.450 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.354813 | 0.450 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.354813 | 0.450 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.354813 | 0.450 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.357414 | 0.447 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.357414 | 0.447 |
| R-HSA-421270 | Cell-cell junction organization | 0.362264 | 0.441 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.362644 | 0.441 |
| R-HSA-420029 | Tight junction interactions | 0.364178 | 0.439 |
| R-HSA-9839394 | TGFBR3 expression | 0.364178 | 0.439 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.364178 | 0.439 |
| R-HSA-2160916 | Hyaluronan degradation | 0.364178 | 0.439 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.364178 | 0.439 |
| R-HSA-3214842 | HDMs demethylate histones | 0.364178 | 0.439 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.364178 | 0.439 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.364178 | 0.439 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.366698 | 0.436 |
| R-HSA-1500931 | Cell-Cell communication | 0.366914 | 0.435 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.367857 | 0.434 |
| R-HSA-9833482 | PKR-mediated signaling | 0.367857 | 0.434 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.367857 | 0.434 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.373407 | 0.428 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.373407 | 0.428 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.373407 | 0.428 |
| R-HSA-525793 | Myogenesis | 0.373407 | 0.428 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.376641 | 0.424 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.377203 | 0.423 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.377260 | 0.423 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.382503 | 0.417 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.382503 | 0.417 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.382503 | 0.417 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.382503 | 0.417 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.382503 | 0.417 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.383396 | 0.416 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.383772 | 0.416 |
| R-HSA-163685 | Integration of energy metabolism | 0.386367 | 0.413 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.390285 | 0.409 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.391468 | 0.407 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.391468 | 0.407 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.391468 | 0.407 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.391468 | 0.407 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.393664 | 0.405 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.393664 | 0.405 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.398769 | 0.399 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.400303 | 0.398 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.400303 | 0.398 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.403855 | 0.394 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.403855 | 0.394 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.408919 | 0.388 |
| R-HSA-70268 | Pyruvate metabolism | 0.408919 | 0.388 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.409010 | 0.388 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.409010 | 0.388 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.409010 | 0.388 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.409010 | 0.388 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.409010 | 0.388 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.409010 | 0.388 |
| R-HSA-72172 | mRNA Splicing | 0.413210 | 0.384 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.413963 | 0.383 |
| R-HSA-9663891 | Selective autophagy | 0.413963 | 0.383 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.417591 | 0.379 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.417591 | 0.379 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.417591 | 0.379 |
| R-HSA-73884 | Base Excision Repair | 0.423987 | 0.373 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.426049 | 0.371 |
| R-HSA-69190 | DNA strand elongation | 0.426049 | 0.371 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.426049 | 0.371 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.433921 | 0.363 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.434383 | 0.362 |
| R-HSA-9930044 | Nuclear RNA decay | 0.434383 | 0.362 |
| R-HSA-9733709 | Cardiogenesis | 0.434383 | 0.362 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.434383 | 0.362 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.434383 | 0.362 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.434383 | 0.362 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.434383 | 0.362 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.434383 | 0.362 |
| R-HSA-69242 | S Phase | 0.436736 | 0.360 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.438854 | 0.358 |
| R-HSA-446728 | Cell junction organization | 0.439618 | 0.357 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.442598 | 0.354 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.442598 | 0.354 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.442598 | 0.354 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.442598 | 0.354 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.442598 | 0.354 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.450694 | 0.346 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.450694 | 0.346 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.450694 | 0.346 |
| R-HSA-69306 | DNA Replication | 0.455710 | 0.341 |
| R-HSA-418990 | Adherens junctions interactions | 0.458350 | 0.339 |
| R-HSA-169911 | Regulation of Apoptosis | 0.458672 | 0.338 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.458672 | 0.338 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.458672 | 0.338 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.463226 | 0.334 |
| R-HSA-111933 | Calmodulin induced events | 0.466535 | 0.331 |
| R-HSA-111997 | CaM pathway | 0.466535 | 0.331 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.466535 | 0.331 |
| R-HSA-8853659 | RET signaling | 0.466535 | 0.331 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.466535 | 0.331 |
| R-HSA-9612973 | Autophagy | 0.466967 | 0.331 |
| R-HSA-157579 | Telomere Maintenance | 0.467947 | 0.330 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.467947 | 0.330 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.467947 | 0.330 |
| R-HSA-190236 | Signaling by FGFR | 0.472709 | 0.325 |
| R-HSA-4641258 | Degradation of DVL | 0.474285 | 0.324 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.474285 | 0.324 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.474285 | 0.324 |
| R-HSA-3214847 | HATs acetylate histones | 0.477445 | 0.321 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.477445 | 0.321 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.481815 | 0.317 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.481922 | 0.317 |
| R-HSA-109581 | Apoptosis | 0.489166 | 0.311 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.489449 | 0.310 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.489874 | 0.310 |
| R-HSA-597592 | Post-translational protein modification | 0.490174 | 0.310 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.491498 | 0.308 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.496867 | 0.304 |
| R-HSA-9646399 | Aggrephagy | 0.496867 | 0.304 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.496867 | 0.304 |
| R-HSA-202433 | Generation of second messenger molecules | 0.496867 | 0.304 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.496867 | 0.304 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.500734 | 0.300 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.500734 | 0.300 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.504177 | 0.297 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.504177 | 0.297 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.504177 | 0.297 |
| R-HSA-9607240 | FLT3 Signaling | 0.504177 | 0.297 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.505312 | 0.296 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.505312 | 0.296 |
| R-HSA-9833110 | RSV-host interactions | 0.505312 | 0.296 |
| R-HSA-5619102 | SLC transporter disorders | 0.507319 | 0.295 |
| R-HSA-1266738 | Developmental Biology | 0.507439 | 0.295 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.511382 | 0.291 |
| R-HSA-165159 | MTOR signalling | 0.518483 | 0.285 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.518483 | 0.285 |
| R-HSA-111996 | Ca-dependent events | 0.518483 | 0.285 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.523349 | 0.281 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.528654 | 0.277 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.532160 | 0.274 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.532160 | 0.274 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.532377 | 0.274 |
| R-HSA-69236 | G1 Phase | 0.532377 | 0.274 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.532377 | 0.274 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.539129 | 0.268 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.539174 | 0.268 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.539174 | 0.268 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.539174 | 0.268 |
| R-HSA-913531 | Interferon Signaling | 0.539302 | 0.268 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.545872 | 0.263 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.545872 | 0.263 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.545872 | 0.263 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.545872 | 0.263 |
| R-HSA-75153 | Apoptotic execution phase | 0.545872 | 0.263 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.549568 | 0.260 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.552473 | 0.258 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.552875 | 0.257 |
| R-HSA-168255 | Influenza Infection | 0.552887 | 0.257 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.558979 | 0.253 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.558979 | 0.253 |
| R-HSA-425410 | Metal ion SLC transporters | 0.558979 | 0.253 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.562294 | 0.250 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.565391 | 0.248 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.565391 | 0.248 |
| R-HSA-373760 | L1CAM interactions | 0.566479 | 0.247 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.570635 | 0.244 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.571710 | 0.243 |
| R-HSA-69275 | G2/M Transition | 0.576371 | 0.239 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.577937 | 0.238 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.582938 | 0.234 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.584074 | 0.234 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.584074 | 0.234 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.584074 | 0.234 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.586971 | 0.231 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.590123 | 0.229 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.590123 | 0.229 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.590123 | 0.229 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.590123 | 0.229 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.594965 | 0.226 |
| R-HSA-416476 | G alpha (q) signalling events | 0.596169 | 0.225 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.601958 | 0.220 |
| R-HSA-69206 | G1/S Transition | 0.606740 | 0.217 |
| R-HSA-194138 | Signaling by VEGF | 0.606740 | 0.217 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.607151 | 0.217 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.607747 | 0.216 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.607747 | 0.216 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.607747 | 0.216 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.613453 | 0.212 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.619075 | 0.208 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.620970 | 0.207 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.620970 | 0.207 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.624617 | 0.204 |
| R-HSA-186712 | Regulation of beta-cell development | 0.624617 | 0.204 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.630078 | 0.201 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.630078 | 0.201 |
| R-HSA-983189 | Kinesins | 0.630078 | 0.201 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.630078 | 0.201 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.630078 | 0.201 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.630104 | 0.201 |
| R-HSA-211976 | Endogenous sterols | 0.635460 | 0.197 |
| R-HSA-112043 | PLC beta mediated events | 0.635460 | 0.197 |
| R-HSA-5357801 | Programmed Cell Death | 0.639085 | 0.194 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.640764 | 0.193 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.640764 | 0.193 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.640764 | 0.193 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.640764 | 0.193 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.645991 | 0.190 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.645991 | 0.190 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.645991 | 0.190 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.645991 | 0.190 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.661223 | 0.180 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.666153 | 0.176 |
| R-HSA-112040 | G-protein mediated events | 0.666153 | 0.176 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.666153 | 0.176 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.671013 | 0.173 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.671013 | 0.173 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.671013 | 0.173 |
| R-HSA-1632852 | Macroautophagy | 0.671956 | 0.173 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.680521 | 0.167 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.680521 | 0.167 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.680521 | 0.167 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.680521 | 0.167 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.680521 | 0.167 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.680521 | 0.167 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.680521 | 0.167 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.685172 | 0.164 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.685172 | 0.164 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.689755 | 0.161 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.689755 | 0.161 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.694272 | 0.158 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.694272 | 0.158 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.694853 | 0.158 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.697657 | 0.156 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.698724 | 0.156 |
| R-HSA-9758941 | Gastrulation | 0.701149 | 0.154 |
| R-HSA-380287 | Centrosome maturation | 0.703111 | 0.153 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.703111 | 0.153 |
| R-HSA-8852135 | Protein ubiquitination | 0.703111 | 0.153 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.707337 | 0.150 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.707435 | 0.150 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.709817 | 0.149 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.715894 | 0.145 |
| R-HSA-4086400 | PCP/CE pathway | 0.715894 | 0.145 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.715894 | 0.145 |
| R-HSA-9659379 | Sensory processing of sound | 0.720032 | 0.143 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.720032 | 0.143 |
| R-HSA-6806834 | Signaling by MET | 0.724110 | 0.140 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.732090 | 0.135 |
| R-HSA-157118 | Signaling by NOTCH | 0.732548 | 0.135 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.739840 | 0.131 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.747366 | 0.126 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.748774 | 0.126 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.751048 | 0.124 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.754676 | 0.122 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.758251 | 0.120 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.765247 | 0.116 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.768669 | 0.114 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.768669 | 0.114 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.768669 | 0.114 |
| R-HSA-391251 | Protein folding | 0.775365 | 0.110 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.778640 | 0.109 |
| R-HSA-9675108 | Nervous system development | 0.779568 | 0.108 |
| R-HSA-2559583 | Cellular Senescence | 0.787946 | 0.104 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.788219 | 0.103 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.791272 | 0.102 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.791272 | 0.102 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.791272 | 0.102 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.797316 | 0.098 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.797316 | 0.098 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.800272 | 0.097 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.806057 | 0.094 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.808886 | 0.092 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.811674 | 0.091 |
| R-HSA-111885 | Opioid Signalling | 0.814422 | 0.089 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.816376 | 0.088 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.818408 | 0.087 |
| R-HSA-418346 | Platelet homeostasis | 0.822428 | 0.085 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.822428 | 0.085 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.826184 | 0.083 |
| R-HSA-6798695 | Neutrophil degranulation | 0.828897 | 0.081 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.830090 | 0.081 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.830090 | 0.081 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.832570 | 0.080 |
| R-HSA-202403 | TCR signaling | 0.832570 | 0.080 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.834019 | 0.079 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.835883 | 0.078 |
| R-HSA-1483257 | Phospholipid metabolism | 0.839761 | 0.076 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.839797 | 0.076 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.844441 | 0.073 |
| R-HSA-9679506 | SARS-CoV Infections | 0.848005 | 0.072 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.853331 | 0.069 |
| R-HSA-397014 | Muscle contraction | 0.853504 | 0.069 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.853504 | 0.069 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.855169 | 0.068 |
| R-HSA-1280218 | Adaptive Immune System | 0.859053 | 0.066 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.865726 | 0.063 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.867688 | 0.062 |
| R-HSA-8951664 | Neddylation | 0.867876 | 0.062 |
| R-HSA-114608 | Platelet degranulation | 0.875254 | 0.058 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.877077 | 0.057 |
| R-HSA-5576891 | Cardiac conduction | 0.884109 | 0.053 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.887473 | 0.052 |
| R-HSA-8939211 | ESR-mediated signaling | 0.890279 | 0.050 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.893912 | 0.049 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.893912 | 0.049 |
| R-HSA-5368287 | Mitochondrial translation | 0.896993 | 0.047 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.896993 | 0.047 |
| R-HSA-6807070 | PTEN Regulation | 0.898500 | 0.046 |
| R-HSA-9664407 | Parasite infection | 0.899985 | 0.046 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.899985 | 0.046 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.899985 | 0.046 |
| R-HSA-392499 | Metabolism of proteins | 0.900413 | 0.046 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.901448 | 0.045 |
| R-HSA-166520 | Signaling by NTRKs | 0.912411 | 0.040 |
| R-HSA-9824446 | Viral Infection Pathways | 0.914236 | 0.039 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.914957 | 0.039 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.914957 | 0.039 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.917429 | 0.037 |
| R-HSA-422475 | Axon guidance | 0.918089 | 0.037 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.919489 | 0.036 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.924423 | 0.034 |
| R-HSA-877300 | Interferon gamma signaling | 0.925530 | 0.034 |
| R-HSA-112316 | Neuronal System | 0.928101 | 0.032 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.929297 | 0.032 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.933824 | 0.030 |
| R-HSA-9658195 | Leishmania infection | 0.935028 | 0.029 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.935028 | 0.029 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.935556 | 0.029 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.941197 | 0.026 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.942060 | 0.026 |
| R-HSA-388396 | GPCR downstream signalling | 0.947253 | 0.024 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.950752 | 0.022 |
| R-HSA-5617833 | Cilium Assembly | 0.953580 | 0.021 |
| R-HSA-428157 | Sphingolipid metabolism | 0.960550 | 0.017 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.961187 | 0.017 |
| R-HSA-1643685 | Disease | 0.962181 | 0.017 |
| R-HSA-6805567 | Keratinization | 0.963902 | 0.016 |
| R-HSA-1474244 | Extracellular matrix organization | 0.964866 | 0.016 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.968996 | 0.014 |
| R-HSA-372790 | Signaling by GPCR | 0.974207 | 0.011 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.974701 | 0.011 |
| R-HSA-109582 | Hemostasis | 0.978650 | 0.009 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.984382 | 0.007 |
| R-HSA-8978868 | Fatty acid metabolism | 0.986791 | 0.006 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.987595 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.989123 | 0.005 |
| R-HSA-72766 | Translation | 0.990070 | 0.004 |
| R-HSA-5663205 | Infectious disease | 0.990795 | 0.004 |
| R-HSA-8957322 | Metabolism of steroids | 0.993746 | 0.003 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.996558 | 0.001 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.996789 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.997533 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.997702 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.997931 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.998219 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998826 | 0.001 |
| R-HSA-168256 | Immune System | 0.999213 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999689 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999945 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999995 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999998 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.811 | 0.147 | 2 | 0.824 |
CDC7 |
0.805 | 0.131 | 1 | 0.831 |
PIM3 |
0.804 | 0.133 | -3 | 0.846 |
NDR2 |
0.804 | 0.105 | -3 | 0.856 |
CLK3 |
0.804 | 0.110 | 1 | 0.809 |
MOS |
0.800 | 0.159 | 1 | 0.858 |
RSK2 |
0.797 | 0.121 | -3 | 0.769 |
GRK1 |
0.796 | 0.122 | -2 | 0.821 |
SKMLCK |
0.795 | 0.100 | -2 | 0.874 |
MTOR |
0.794 | 0.111 | 1 | 0.757 |
PRKD1 |
0.791 | 0.087 | -3 | 0.833 |
HIPK4 |
0.790 | 0.072 | 1 | 0.783 |
P90RSK |
0.788 | 0.081 | -3 | 0.774 |
PIM1 |
0.788 | 0.094 | -3 | 0.784 |
ATR |
0.788 | 0.091 | 1 | 0.842 |
IKKB |
0.788 | 0.001 | -2 | 0.734 |
CAMK2A |
0.788 | 0.137 | 2 | 0.777 |
NDR1 |
0.788 | 0.046 | -3 | 0.829 |
RIPK3 |
0.788 | -0.016 | 3 | 0.237 |
SRPK1 |
0.788 | 0.047 | -3 | 0.756 |
CAMK1B |
0.787 | 0.046 | -3 | 0.831 |
CAMK2G |
0.787 | 0.050 | 2 | 0.778 |
PRPK |
0.787 | -0.050 | -1 | 0.860 |
RSK3 |
0.786 | 0.073 | -3 | 0.760 |
CAMK2B |
0.785 | 0.106 | 2 | 0.753 |
RSK4 |
0.785 | 0.113 | -3 | 0.757 |
PDHK4 |
0.784 | -0.032 | 1 | 0.835 |
RAF1 |
0.784 | -0.042 | 1 | 0.831 |
CAMK2D |
0.784 | 0.086 | -3 | 0.823 |
PRKD2 |
0.784 | 0.070 | -3 | 0.766 |
LATS2 |
0.783 | 0.044 | -5 | 0.786 |
AURC |
0.783 | 0.073 | -2 | 0.683 |
PKACG |
0.783 | 0.059 | -2 | 0.775 |
GRK5 |
0.783 | 0.040 | -3 | 0.840 |
KIS |
0.783 | 0.023 | 1 | 0.658 |
IKKA |
0.782 | 0.038 | -2 | 0.724 |
CDKL1 |
0.782 | 0.035 | -3 | 0.799 |
CHAK2 |
0.782 | 0.015 | -1 | 0.841 |
GRK6 |
0.782 | 0.056 | 1 | 0.818 |
MAPKAPK2 |
0.781 | 0.067 | -3 | 0.735 |
GSK3A |
0.780 | 0.150 | 4 | 0.448 |
GRK7 |
0.780 | 0.119 | 1 | 0.746 |
TBK1 |
0.780 | -0.066 | 1 | 0.726 |
MARK4 |
0.780 | -0.021 | 4 | 0.675 |
MSK1 |
0.780 | 0.090 | -3 | 0.749 |
IKKE |
0.780 | -0.052 | 1 | 0.724 |
CAMLCK |
0.779 | 0.027 | -2 | 0.853 |
GCN2 |
0.779 | -0.117 | 2 | 0.767 |
PASK |
0.779 | 0.233 | -3 | 0.875 |
CLK2 |
0.779 | 0.083 | -3 | 0.746 |
DSTYK |
0.779 | -0.025 | 2 | 0.839 |
PKACB |
0.779 | 0.088 | -2 | 0.703 |
GSK3B |
0.779 | 0.131 | 4 | 0.444 |
NLK |
0.779 | -0.024 | 1 | 0.800 |
WNK1 |
0.779 | -0.012 | -2 | 0.885 |
DAPK2 |
0.778 | 0.039 | -3 | 0.845 |
MASTL |
0.778 | 0.005 | -2 | 0.811 |
BMPR2 |
0.778 | -0.083 | -2 | 0.871 |
PRKX |
0.778 | 0.099 | -3 | 0.690 |
ERK5 |
0.778 | 0.003 | 1 | 0.783 |
GRK4 |
0.778 | 0.014 | -2 | 0.839 |
CDKL5 |
0.777 | 0.030 | -3 | 0.794 |
PKN3 |
0.777 | 0.003 | -3 | 0.819 |
HUNK |
0.777 | -0.086 | 2 | 0.808 |
LATS1 |
0.777 | 0.104 | -3 | 0.872 |
PKN2 |
0.776 | 0.011 | -3 | 0.815 |
AMPKA1 |
0.776 | -0.015 | -3 | 0.839 |
MST4 |
0.776 | -0.016 | 2 | 0.820 |
NIK |
0.775 | -0.002 | -3 | 0.849 |
ICK |
0.775 | 0.044 | -3 | 0.838 |
BMPR1B |
0.775 | 0.084 | 1 | 0.786 |
P70S6KB |
0.775 | 0.031 | -3 | 0.775 |
NUAK2 |
0.775 | -0.031 | -3 | 0.827 |
CDK1 |
0.774 | 0.056 | 1 | 0.594 |
FAM20C |
0.774 | 0.012 | 2 | 0.550 |
PKCD |
0.773 | 0.021 | 2 | 0.729 |
MSK2 |
0.773 | 0.033 | -3 | 0.753 |
SRPK2 |
0.773 | 0.023 | -3 | 0.679 |
NEK6 |
0.773 | -0.038 | -2 | 0.841 |
RIPK1 |
0.773 | -0.046 | 1 | 0.825 |
TGFBR2 |
0.773 | -0.042 | -2 | 0.784 |
PDHK1 |
0.773 | -0.111 | 1 | 0.826 |
MAPKAPK3 |
0.772 | 0.011 | -3 | 0.771 |
QSK |
0.772 | 0.002 | 4 | 0.659 |
DLK |
0.772 | 0.038 | 1 | 0.814 |
MLK1 |
0.772 | -0.075 | 2 | 0.757 |
BCKDK |
0.772 | -0.073 | -1 | 0.818 |
DNAPK |
0.771 | 0.095 | 1 | 0.720 |
PAK1 |
0.771 | 0.027 | -2 | 0.791 |
NIM1 |
0.771 | -0.034 | 3 | 0.221 |
ULK2 |
0.771 | -0.122 | 2 | 0.736 |
ATM |
0.770 | 0.006 | 1 | 0.790 |
DYRK2 |
0.770 | 0.026 | 1 | 0.683 |
AMPKA2 |
0.770 | -0.017 | -3 | 0.809 |
SMG1 |
0.770 | 0.074 | 1 | 0.805 |
SRPK3 |
0.770 | 0.005 | -3 | 0.726 |
MLK2 |
0.770 | 0.000 | 2 | 0.773 |
NEK7 |
0.769 | -0.107 | -3 | 0.823 |
TSSK1 |
0.769 | -0.021 | -3 | 0.862 |
PKCA |
0.768 | 0.037 | 2 | 0.672 |
PKCB |
0.768 | 0.013 | 2 | 0.676 |
TLK2 |
0.767 | 0.052 | 1 | 0.808 |
CLK4 |
0.767 | 0.029 | -3 | 0.752 |
TGFBR1 |
0.767 | 0.031 | -2 | 0.801 |
ANKRD3 |
0.767 | -0.043 | 1 | 0.857 |
MLK3 |
0.767 | -0.006 | 2 | 0.688 |
PKCG |
0.766 | 0.010 | 2 | 0.682 |
MYLK4 |
0.766 | 0.016 | -2 | 0.788 |
PKG2 |
0.766 | 0.042 | -2 | 0.708 |
CAMK4 |
0.766 | -0.019 | -3 | 0.797 |
AURB |
0.766 | 0.026 | -2 | 0.679 |
TSSK2 |
0.766 | -0.044 | -5 | 0.836 |
PAK3 |
0.765 | -0.009 | -2 | 0.785 |
CDK7 |
0.765 | 0.001 | 1 | 0.641 |
AKT2 |
0.765 | 0.057 | -3 | 0.683 |
ALK4 |
0.765 | 0.014 | -2 | 0.826 |
MARK3 |
0.765 | -0.017 | 4 | 0.623 |
MNK2 |
0.763 | -0.002 | -2 | 0.798 |
JNK2 |
0.763 | 0.047 | 1 | 0.574 |
TTBK2 |
0.763 | -0.071 | 2 | 0.679 |
WNK3 |
0.763 | -0.183 | 1 | 0.815 |
CDK3 |
0.763 | 0.021 | 1 | 0.537 |
IRE1 |
0.763 | -0.094 | 1 | 0.824 |
CK1E |
0.763 | 0.038 | -3 | 0.604 |
CDK18 |
0.762 | 0.027 | 1 | 0.578 |
CLK1 |
0.762 | 0.021 | -3 | 0.722 |
HIPK2 |
0.762 | 0.033 | 1 | 0.594 |
CDK8 |
0.762 | -0.017 | 1 | 0.638 |
MNK1 |
0.762 | 0.007 | -2 | 0.808 |
JNK3 |
0.762 | 0.031 | 1 | 0.612 |
SGK3 |
0.762 | 0.040 | -3 | 0.761 |
SIK |
0.761 | -0.020 | -3 | 0.738 |
PKCZ |
0.761 | -0.016 | 2 | 0.723 |
CDK19 |
0.761 | -0.006 | 1 | 0.600 |
PRKD3 |
0.761 | 0.008 | -3 | 0.726 |
PIM2 |
0.761 | 0.047 | -3 | 0.731 |
NEK9 |
0.760 | -0.125 | 2 | 0.785 |
PKR |
0.760 | -0.037 | 1 | 0.858 |
CK2A2 |
0.760 | 0.036 | 1 | 0.689 |
ULK1 |
0.760 | -0.126 | -3 | 0.769 |
MEK1 |
0.760 | -0.042 | 2 | 0.822 |
AURA |
0.760 | 0.023 | -2 | 0.650 |
PLK1 |
0.760 | -0.041 | -2 | 0.780 |
ACVR2B |
0.760 | 0.024 | -2 | 0.782 |
QIK |
0.760 | -0.080 | -3 | 0.810 |
VRK2 |
0.760 | -0.068 | 1 | 0.867 |
PAK2 |
0.760 | -0.018 | -2 | 0.772 |
PKACA |
0.759 | 0.058 | -2 | 0.656 |
YSK4 |
0.759 | -0.007 | 1 | 0.767 |
ALK2 |
0.759 | 0.017 | -2 | 0.814 |
MPSK1 |
0.759 | 0.106 | 1 | 0.842 |
CDK5 |
0.759 | -0.014 | 1 | 0.666 |
HIPK1 |
0.759 | 0.029 | 1 | 0.705 |
DYRK4 |
0.759 | 0.032 | 1 | 0.598 |
MARK2 |
0.758 | -0.047 | 4 | 0.596 |
DCAMKL1 |
0.758 | 0.021 | -3 | 0.774 |
CDK2 |
0.758 | -0.013 | 1 | 0.677 |
MLK4 |
0.758 | -0.037 | 2 | 0.667 |
PLK3 |
0.758 | -0.018 | 2 | 0.754 |
MELK |
0.758 | -0.046 | -3 | 0.784 |
CAMK1G |
0.758 | 0.001 | -3 | 0.737 |
BRSK1 |
0.757 | -0.056 | -3 | 0.776 |
NUAK1 |
0.757 | -0.049 | -3 | 0.766 |
PHKG1 |
0.757 | -0.052 | -3 | 0.815 |
DRAK1 |
0.757 | -0.010 | 1 | 0.746 |
IRE2 |
0.757 | -0.089 | 2 | 0.668 |
PAK6 |
0.756 | 0.022 | -2 | 0.702 |
CK1A2 |
0.756 | 0.048 | -3 | 0.554 |
CK1D |
0.756 | 0.049 | -3 | 0.554 |
P38A |
0.756 | 0.009 | 1 | 0.674 |
GRK2 |
0.756 | -0.009 | -2 | 0.727 |
P38B |
0.756 | 0.031 | 1 | 0.594 |
ACVR2A |
0.756 | -0.007 | -2 | 0.766 |
GAK |
0.755 | 0.155 | 1 | 0.893 |
CDK13 |
0.755 | -0.029 | 1 | 0.613 |
PKCH |
0.755 | -0.034 | 2 | 0.658 |
MST3 |
0.755 | 0.023 | 2 | 0.808 |
CK1G1 |
0.755 | 0.012 | -3 | 0.580 |
BRSK2 |
0.755 | -0.076 | -3 | 0.791 |
PLK4 |
0.754 | -0.028 | 2 | 0.616 |
MARK1 |
0.754 | -0.055 | 4 | 0.628 |
BMPR1A |
0.754 | 0.034 | 1 | 0.766 |
CK2A1 |
0.754 | 0.036 | 1 | 0.666 |
CDK17 |
0.753 | 0.009 | 1 | 0.515 |
CHK1 |
0.753 | -0.003 | -3 | 0.816 |
CHAK1 |
0.753 | -0.117 | 2 | 0.739 |
CDK14 |
0.751 | 0.014 | 1 | 0.625 |
NEK2 |
0.751 | -0.086 | 2 | 0.766 |
JNK1 |
0.750 | 0.032 | 1 | 0.562 |
CDK10 |
0.750 | 0.019 | 1 | 0.611 |
ERK1 |
0.750 | -0.009 | 1 | 0.587 |
SNRK |
0.750 | -0.123 | 2 | 0.649 |
DYRK1A |
0.749 | -0.005 | 1 | 0.702 |
AKT1 |
0.749 | 0.034 | -3 | 0.704 |
DCAMKL2 |
0.749 | 0.004 | -3 | 0.781 |
SMMLCK |
0.749 | -0.003 | -3 | 0.795 |
MAPKAPK5 |
0.749 | -0.048 | -3 | 0.716 |
P38G |
0.749 | 0.005 | 1 | 0.507 |
MEKK3 |
0.749 | -0.067 | 1 | 0.793 |
CDK12 |
0.749 | -0.025 | 1 | 0.582 |
TLK1 |
0.749 | -0.041 | -2 | 0.823 |
NEK5 |
0.749 | -0.027 | 1 | 0.845 |
AKT3 |
0.749 | 0.078 | -3 | 0.637 |
CDK9 |
0.748 | -0.040 | 1 | 0.622 |
PRP4 |
0.748 | 0.009 | -3 | 0.783 |
MEK5 |
0.748 | -0.109 | 2 | 0.787 |
PLK2 |
0.747 | 0.050 | -3 | 0.758 |
MAK |
0.746 | 0.085 | -2 | 0.741 |
LKB1 |
0.746 | 0.059 | -3 | 0.828 |
DAPK3 |
0.746 | 0.025 | -3 | 0.787 |
ZAK |
0.746 | -0.061 | 1 | 0.774 |
GRK3 |
0.746 | -0.008 | -2 | 0.692 |
P70S6K |
0.746 | -0.001 | -3 | 0.691 |
GCK |
0.746 | 0.084 | 1 | 0.788 |
TAO3 |
0.746 | -0.013 | 1 | 0.783 |
MEKK1 |
0.746 | -0.110 | 1 | 0.811 |
DYRK1B |
0.746 | -0.004 | 1 | 0.636 |
DAPK1 |
0.746 | 0.038 | -3 | 0.774 |
HIPK3 |
0.745 | -0.016 | 1 | 0.689 |
DYRK3 |
0.745 | 0.007 | 1 | 0.714 |
MEKK2 |
0.745 | -0.063 | 2 | 0.752 |
NEK11 |
0.745 | -0.018 | 1 | 0.773 |
WNK4 |
0.744 | -0.108 | -2 | 0.871 |
SSTK |
0.744 | -0.057 | 4 | 0.638 |
PAK4 |
0.744 | 0.023 | -2 | 0.650 |
CAMK1D |
0.744 | 0.005 | -3 | 0.675 |
BRAF |
0.744 | -0.043 | -4 | 0.837 |
IRAK4 |
0.744 | -0.095 | 1 | 0.832 |
ERK2 |
0.744 | -0.043 | 1 | 0.631 |
PKCT |
0.743 | -0.041 | 2 | 0.667 |
P38D |
0.743 | 0.013 | 1 | 0.543 |
PERK |
0.743 | -0.129 | -2 | 0.820 |
CDK16 |
0.742 | 0.012 | 1 | 0.537 |
SGK1 |
0.742 | 0.052 | -3 | 0.618 |
PKCE |
0.742 | -0.008 | 2 | 0.666 |
CAMKK2 |
0.741 | 0.022 | -2 | 0.744 |
PAK5 |
0.740 | 0.001 | -2 | 0.641 |
YANK3 |
0.739 | 0.046 | 2 | 0.419 |
HPK1 |
0.739 | 0.037 | 1 | 0.773 |
PKCI |
0.738 | -0.049 | 2 | 0.687 |
PDK1 |
0.738 | -0.022 | 1 | 0.784 |
HRI |
0.737 | -0.174 | -2 | 0.825 |
PINK1 |
0.737 | -0.116 | 1 | 0.840 |
ROCK2 |
0.737 | 0.038 | -3 | 0.781 |
MRCKA |
0.737 | 0.034 | -3 | 0.735 |
TTBK1 |
0.737 | -0.089 | 2 | 0.601 |
BUB1 |
0.737 | 0.060 | -5 | 0.787 |
PBK |
0.736 | 0.097 | 1 | 0.839 |
STK33 |
0.736 | -0.026 | 2 | 0.611 |
CAMKK1 |
0.736 | -0.059 | -2 | 0.747 |
TAK1 |
0.735 | 0.042 | 1 | 0.811 |
TNIK |
0.734 | -0.024 | 3 | 0.253 |
MST2 |
0.734 | -0.028 | 1 | 0.798 |
IRAK1 |
0.734 | -0.168 | -1 | 0.755 |
MRCKB |
0.733 | 0.021 | -3 | 0.716 |
MAP3K15 |
0.733 | -0.032 | 1 | 0.756 |
NEK4 |
0.732 | -0.073 | 1 | 0.801 |
NEK8 |
0.732 | -0.113 | 2 | 0.761 |
EEF2K |
0.732 | -0.069 | 3 | 0.262 |
MOK |
0.732 | 0.035 | 1 | 0.738 |
KHS2 |
0.732 | 0.014 | 1 | 0.784 |
HGK |
0.732 | -0.045 | 3 | 0.264 |
DMPK1 |
0.731 | 0.057 | -3 | 0.737 |
KHS1 |
0.731 | 0.006 | 1 | 0.776 |
MEKK6 |
0.731 | -0.067 | 1 | 0.792 |
MINK |
0.731 | -0.041 | 1 | 0.792 |
PHKG2 |
0.730 | -0.113 | -3 | 0.758 |
CHK2 |
0.730 | -0.006 | -3 | 0.624 |
LRRK2 |
0.730 | -0.065 | 2 | 0.801 |
TAO2 |
0.730 | -0.115 | 2 | 0.793 |
PDHK3_TYR |
0.730 | 0.232 | 4 | 0.716 |
VRK1 |
0.729 | -0.096 | 2 | 0.785 |
SBK |
0.729 | 0.038 | -3 | 0.566 |
ERK7 |
0.728 | -0.025 | 2 | 0.494 |
CAMK1A |
0.728 | -0.002 | -3 | 0.638 |
PKN1 |
0.728 | -0.034 | -3 | 0.707 |
NEK1 |
0.727 | -0.070 | 1 | 0.814 |
CK1A |
0.727 | 0.027 | -3 | 0.468 |
CDK6 |
0.727 | -0.037 | 1 | 0.606 |
SLK |
0.727 | -0.027 | -2 | 0.704 |
CRIK |
0.726 | 0.055 | -3 | 0.711 |
MST1 |
0.726 | -0.037 | 1 | 0.786 |
LOK |
0.726 | -0.048 | -2 | 0.762 |
PDHK4_TYR |
0.725 | 0.183 | 2 | 0.853 |
PKG1 |
0.723 | -0.003 | -2 | 0.625 |
MAP2K6_TYR |
0.721 | 0.121 | -1 | 0.873 |
CDK4 |
0.720 | -0.049 | 1 | 0.572 |
MAP2K4_TYR |
0.720 | 0.138 | -1 | 0.875 |
YSK1 |
0.718 | -0.075 | 2 | 0.757 |
ROCK1 |
0.718 | 0.001 | -3 | 0.733 |
TTK |
0.717 | -0.051 | -2 | 0.805 |
BMPR2_TYR |
0.717 | 0.095 | -1 | 0.875 |
RIPK2 |
0.717 | -0.190 | 1 | 0.728 |
TESK1_TYR |
0.716 | 0.018 | 3 | 0.286 |
OSR1 |
0.716 | -0.042 | 2 | 0.772 |
MEK2 |
0.716 | -0.156 | 2 | 0.780 |
PDHK1_TYR |
0.715 | 0.093 | -1 | 0.873 |
PKMYT1_TYR |
0.715 | -0.012 | 3 | 0.270 |
BIKE |
0.714 | 0.064 | 1 | 0.813 |
HASPIN |
0.713 | -0.030 | -1 | 0.713 |
ALPHAK3 |
0.712 | -0.001 | -1 | 0.761 |
MAP2K7_TYR |
0.712 | -0.057 | 2 | 0.825 |
MYO3B |
0.710 | -0.046 | 2 | 0.772 |
LIMK2_TYR |
0.710 | 0.007 | -3 | 0.865 |
EPHA6 |
0.708 | -0.006 | -1 | 0.843 |
YANK2 |
0.707 | 0.029 | 2 | 0.423 |
NEK3 |
0.706 | -0.136 | 1 | 0.763 |
ASK1 |
0.706 | -0.089 | 1 | 0.742 |
TNK2 |
0.705 | -0.021 | 3 | 0.205 |
EPHB4 |
0.705 | -0.034 | -1 | 0.821 |
MYO3A |
0.704 | -0.069 | 1 | 0.791 |
FGR |
0.703 | 0.001 | 1 | 0.852 |
TXK |
0.702 | 0.024 | 1 | 0.811 |
CK1G3 |
0.702 | 0.015 | -3 | 0.421 |
PINK1_TYR |
0.702 | -0.171 | 1 | 0.824 |
DDR1 |
0.702 | -0.093 | 4 | 0.645 |
CK1G2 |
0.701 | 0.030 | -3 | 0.506 |
AAK1 |
0.700 | 0.091 | 1 | 0.727 |
EPHA4 |
0.700 | -0.004 | 2 | 0.772 |
RET |
0.700 | -0.133 | 1 | 0.796 |
YES1 |
0.698 | -0.065 | -1 | 0.832 |
MST1R |
0.697 | -0.173 | 3 | 0.206 |
LIMK1_TYR |
0.697 | -0.168 | 2 | 0.801 |
TYRO3 |
0.696 | -0.160 | 3 | 0.190 |
FER |
0.696 | -0.090 | 1 | 0.848 |
TAO1 |
0.695 | -0.141 | 1 | 0.717 |
SRMS |
0.695 | -0.059 | 1 | 0.827 |
CSF1R |
0.695 | -0.155 | 3 | 0.193 |
INSRR |
0.695 | -0.131 | 3 | 0.203 |
EPHB1 |
0.695 | -0.073 | 1 | 0.820 |
LCK |
0.695 | -0.039 | -1 | 0.821 |
FGFR2 |
0.694 | -0.083 | 3 | 0.269 |
ABL2 |
0.694 | -0.102 | -1 | 0.786 |
ROS1 |
0.694 | -0.181 | 3 | 0.173 |
BLK |
0.694 | -0.028 | -1 | 0.814 |
FYN |
0.694 | 0.006 | -1 | 0.806 |
ITK |
0.694 | -0.062 | -1 | 0.791 |
EPHB3 |
0.694 | -0.061 | -1 | 0.803 |
JAK3 |
0.693 | -0.116 | 1 | 0.772 |
KDR |
0.693 | -0.097 | 3 | 0.199 |
ABL1 |
0.692 | -0.096 | -1 | 0.781 |
HCK |
0.692 | -0.099 | -1 | 0.815 |
STLK3 |
0.692 | -0.109 | 1 | 0.739 |
EPHB2 |
0.691 | -0.068 | -1 | 0.796 |
JAK2 |
0.691 | -0.194 | 1 | 0.785 |
DDR2 |
0.691 | -0.057 | 3 | 0.227 |
KIT |
0.690 | -0.130 | 3 | 0.212 |
TYK2 |
0.690 | -0.254 | 1 | 0.797 |
TNK1 |
0.690 | -0.097 | 3 | 0.186 |
EPHA7 |
0.689 | -0.045 | 2 | 0.761 |
MET |
0.689 | -0.095 | 3 | 0.201 |
MERTK |
0.688 | -0.103 | 3 | 0.202 |
TEK |
0.688 | -0.131 | 3 | 0.185 |
AXL |
0.688 | -0.120 | 3 | 0.205 |
EPHA3 |
0.688 | -0.062 | 2 | 0.739 |
FLT1 |
0.687 | -0.040 | -1 | 0.815 |
FGFR3 |
0.686 | -0.092 | 3 | 0.253 |
BMX |
0.686 | -0.066 | -1 | 0.713 |
LYN |
0.684 | -0.080 | 3 | 0.177 |
FGFR1 |
0.684 | -0.154 | 3 | 0.201 |
NEK10_TYR |
0.684 | -0.089 | 1 | 0.677 |
PDGFRB |
0.683 | -0.198 | 3 | 0.201 |
SRC |
0.683 | -0.045 | -1 | 0.799 |
EPHA5 |
0.682 | -0.062 | 2 | 0.751 |
TEC |
0.682 | -0.109 | -1 | 0.722 |
PTK2B |
0.682 | -0.072 | -1 | 0.759 |
PTK6 |
0.682 | -0.096 | -1 | 0.732 |
JAK1 |
0.681 | -0.128 | 1 | 0.733 |
TNNI3K_TYR |
0.681 | -0.092 | 1 | 0.809 |
ALK |
0.681 | -0.170 | 3 | 0.167 |
LTK |
0.681 | -0.147 | 3 | 0.192 |
WEE1_TYR |
0.681 | -0.103 | -1 | 0.759 |
PTK2 |
0.681 | 0.013 | -1 | 0.790 |
ERBB2 |
0.680 | -0.119 | 1 | 0.745 |
EPHA1 |
0.679 | -0.140 | 3 | 0.180 |
EPHA8 |
0.679 | -0.068 | -1 | 0.791 |
NTRK1 |
0.678 | -0.165 | -1 | 0.805 |
FLT4 |
0.678 | -0.140 | 3 | 0.225 |
FLT3 |
0.677 | -0.233 | 3 | 0.186 |
BTK |
0.677 | -0.186 | -1 | 0.758 |
NTRK3 |
0.676 | -0.104 | -1 | 0.761 |
FRK |
0.675 | -0.138 | -1 | 0.807 |
INSR |
0.675 | -0.175 | 3 | 0.182 |
PDGFRA |
0.675 | -0.221 | 3 | 0.191 |
SYK |
0.674 | 0.004 | -1 | 0.762 |
EPHA2 |
0.674 | -0.057 | -1 | 0.759 |
NTRK2 |
0.672 | -0.197 | 3 | 0.188 |
FGFR4 |
0.672 | -0.068 | -1 | 0.751 |
ERBB4 |
0.671 | -0.044 | 1 | 0.670 |
MATK |
0.670 | -0.103 | -1 | 0.715 |
CSK |
0.670 | -0.115 | 2 | 0.762 |
EGFR |
0.669 | -0.071 | 1 | 0.649 |
IGF1R |
0.666 | -0.144 | 3 | 0.173 |
ZAP70 |
0.658 | -0.013 | -1 | 0.700 |
FES |
0.655 | -0.121 | -1 | 0.698 |
MUSK |
0.651 | -0.164 | 1 | 0.654 |