Motif 484 (n=232)

Position-wise Probabilities

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uniprot genes site source protein function
A1L170 C1orf226 S244 ochoa Uncharacterized protein C1orf226 None
A2RUS2 DENND3 S489 ochoa DENN domain-containing protein 3 Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}.
A8CG34 POM121C S246 ochoa Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
O00560 SDCBP S74 ochoa Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}.
O14579 COPE S95 ochoa Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
O14639 ABLIM1 S655 ochoa Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.
O14974 PPP1R12A S896 ochoa Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O15014 ZNF609 S453 ochoa Zinc finger protein 609 Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}.
O15516 CLOCK S427 ochoa|psp Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.
O15530 PDPK1 S396 psp 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}.
O43303 CCP110 S366 ochoa|psp Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}.
O43524 FOXO3 S399 ochoa|psp Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O43663 PRC1 S557 ochoa Protein regulator of cytokinesis 1 Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}.
O43663 PRC1 S587 ochoa Protein regulator of cytokinesis 1 Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}.
O60293 ZFC3H1 S28 ochoa Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}.
O60318 MCM3AP S408 ochoa Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}.
O60343 TBC1D4 S304 ochoa TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}.
O60563 CCNT1 S563 ochoa Cyclin-T1 (CycT1) (Cyclin-T) Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}.
O60716 CTNND1 S847 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O60941 DTNB S594 ochoa Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}.
O75044 SRGAP2 S916 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75122 CLASP2 S993 ochoa CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O75369 FLNB S1902 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O94929 ABLIM3 S585 ochoa Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.
O95071 UBR5 S2469 ochoa E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O95835 LATS1 S202 ochoa Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}.
O96013 PAK4 S167 ochoa Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}.
P00533 EGFR S1057 ochoa Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.
P00533 EGFR S1190 ochoa|psp Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.
P02545 LMNA S390 ochoa|psp Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P02671 FGA S276 ochoa Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P02671 FGA S562 ochoa Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P02686 MBP S26 ochoa Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.
P04049 RAF1 S243 ochoa RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P11274 BCR S221 ochoa Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}.
P13569 CFTR S686 psp Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.
P13994 YJU2B S286 ochoa Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}.
P15822 HIVEP1 S1735 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P15924 DSP S2575 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P17661 DES S344 ochoa Desmin Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}.
P19532 TFE3 S554 ochoa Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}.
P19838 NFKB1 S923 ochoa|psp Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}.
P20700 LMNB1 S288 ochoa Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P20700 LMNB1 S391 ochoa Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P23327 HRC S145 ochoa Sarcoplasmic reticulum histidine-rich calcium-binding protein May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
P23921 RRM1 S119 ochoa Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
P26045 PTPN3 S381 ochoa|psp Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
P31629 HIVEP2 S950 ochoa Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
P32241 VIPR1 S435 psp Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}.
P38398 BRCA1 S1466 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P42331 ARHGAP25 S473 ochoa Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
P46013 MKI67 S2814 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46087 NOP2 S44 ochoa 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
P48634 PRRC2A S146 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P49792 RANBP2 S1495 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50443 SLC26A2 S22 ochoa Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2) Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:11448940, PubMed:15294877, PubMed:20219950, PubMed:7923357). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity). {ECO:0000250|UniProtKB:Q62273, ECO:0000269|PubMed:11448940, ECO:0000269|PubMed:15294877, ECO:0000269|PubMed:20219950, ECO:0000269|PubMed:7923357}.
P50993 ATP1A2 S482 ochoa Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}.
P52272 HNRNPM S467 ochoa Heterogeneous nuclear ribonucleoprotein M (hnRNP M) Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
P56524 HDAC4 S196 ochoa Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P57078 RIPK4 S430 ochoa Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}.
P61978 HNRNPK S75 ochoa Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.
P82094 TMF1 S155 ochoa TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.
P82094 TMF1 S156 ochoa TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.
Q00613 HSF1 S216 ochoa|psp Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}.
Q01814 ATP2B2 S1149 ochoa Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}.
Q03164 KMT2A S518 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q03252 LMNB2 S405 ochoa|psp Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q08495 DMTN S289 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q08999 RBL2 S952 ochoa|psp Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Q12774 ARHGEF5 S643 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12791 KCNMA1 S978 psp Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:14523450, PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic transmission (PubMed:32958651). {ECO:0000269|PubMed:14523450, ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168, ECO:0000269|PubMed:32958651}.; FUNCTION: [Isoform 5]: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). {ECO:0000269|PubMed:7573516, ECO:0000269|PubMed:7877450}.
Q12888 TP53BP1 S105 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12955 ANK3 S1445 ochoa Ankyrin-3 (ANK-3) (Ankyrin-G) Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.
Q12968 NFATC3 S247 ochoa Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}.
Q12986 NFX1 S136 ochoa Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.
Q13085 ACACA S1204 ochoa Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.
Q13263 TRIM28 S459 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13418 ILK S232 ochoa Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:16517730, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:18283114, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:30367047, ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:9736715}.
Q13439 GOLGA4 S27 ochoa Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.
Q13796 SHROOM2 S217 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q14161 GIT2 S500 ochoa ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}.
Q14244 MAP7 S169 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q14683 SMC1A S957 ochoa|psp Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}.
Q14738 PPP2R5D S75 ochoa|psp Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q14789 GOLGB1 S525 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q15032 R3HDM1 S347 ochoa R3H domain-containing protein 1 None
Q15149 PLEC S4656 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15544 TAF11 S60 ochoa Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473). {ECO:0000269|PubMed:33795473}.
Q15746 MYLK S1759 ochoa Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}.
Q16891 IMMT S514 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q29RF7 PDS5A S1172 ochoa Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.
Q2M2I8 AAK1 S623 ochoa AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}.
Q4G0J3 LARP7 S244 ochoa La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}.
Q4L180 FILIP1L S1035 ochoa Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}.
Q5BKX6 SLC45A4 S410 ochoa Solute carrier family 45 member 4 Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}.
Q5H9L2 TCEAL5 S127 ochoa Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) May be involved in transcriptional regulation.
Q5JRA6 MIA3 S1731 ochoa Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}.
Q5PRF9 SAMD4B S628 ochoa Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}.
Q5QJE6 DNTTIP2 S239 ochoa Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.
Q5T5P2 KIAA1217 S1245 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5T8D3 ACBD5 S404 ochoa Acyl-CoA-binding domain-containing protein 5 Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}.
Q5TH69 ARFGEF3 S2081 ochoa Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}.
Q5VT52 RPRD2 S744 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q674X7 KAZN S332 ochoa Kazrin Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}.
Q6BDS2 BLTP3A S936 ochoa Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}.
Q6IPX3 TCEAL6 S121 ochoa Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) May be involved in transcriptional regulation.
Q6NZ67 MZT2B S125 ochoa Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:39321809}.
Q6P4F7 ARHGAP11A S606 ochoa Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}.
Q6WCQ1 MPRIP S251 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6WKZ4 RAB11FIP1 S266 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6XZF7 DNMBP S482 ochoa Dynamin-binding protein (Scaffold protein Tuba) Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}.
Q6ZSZ5 ARHGEF18 S71 ochoa Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}.
Q6ZT07 TBC1D9 S415 ochoa TBC1 domain family member 9 (TBC1 domain family member 9A) May act as a GTPase-activating protein for Rab family protein(s).
Q7KZI7 MARK2 S386 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q7L5A3 ATOSB S254 ochoa Atos homolog protein B Transcription regulator that may syncronize transcriptional and translational programs. {ECO:0000250|UniProtKB:Q8BR27}.
Q7Z2W4 ZC3HAV1 S221 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z2W4 ZC3HAV1 S235 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z2W4 ZC3HAV1 S444 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z309 PABIR2 S36 ochoa PABIR family member 2 None
Q7Z402 TMC7 S72 ochoa Transmembrane channel-like protein 7 Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}.
Q7Z589 EMSY S195 ochoa BRCA2-interacting transcriptional repressor EMSY Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.
Q7Z7G8 VPS13B S1019 ochoa Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}.
Q86U86 PBRM1 S934 ochoa Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q86UE4 MTDH S294 ochoa Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.
Q86UU1 PHLDB1 S506 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86UU1 PHLDB1 S564 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86UU1 PHLDB1 S664 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86UU1 PHLDB1 S678 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86X29 LSR S418 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q8N1F7 NUP93 S66 ochoa Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.
Q8N568 DCLK2 S361 ochoa Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.
Q8N8Z6 DCBLD1 S683 psp Discoidin, CUB and LCCL domain-containing protein 1 None
Q8NEY1 NAV1 S1167 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NEY8 PPHLN1 S133 ochoa Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}.
Q8NFH3 NUP43 S299 ochoa Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269|PubMed:17363900}.
Q8NG31 KNL1 S1831 ochoa Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}.
Q8NHV4 NEDD1 S397 ochoa|psp Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8TAA9 VANGL1 S325 ochoa Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) None
Q8TEA8 DTD1 S182 psp D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}.
Q8TF72 SHROOM3 S663 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WX93 PALLD S1104 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WXE9 STON2 S354 ochoa Stonin-2 (Stoned B) Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}.
Q8WZ73 RFFL S226 ochoa E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}.
Q92613 JADE3 S780 ochoa Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}.
Q92619 ARHGAP45 S53 ochoa Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}.
Q92619 ARHGAP45 S564 ochoa Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}.
Q92621 NUP205 S1153 ochoa Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}.
Q92844 TANK S211 ochoa TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}.
Q92974 ARHGEF2 S172 ochoa|psp Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.
Q969E4 TCEAL3 S121 ochoa Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) May be involved in transcriptional regulation.
Q96E09 PABIR1 S48 ochoa PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
Q96EV8 DTNBP1 S297 ochoa|psp Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein) Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269|PubMed:15345706, ECO:0000269|PubMed:16837549, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:17989303, ECO:0000269|PubMed:19094965, ECO:0000269|PubMed:20180862, ECO:0000269|PubMed:20921223}.
Q96HA1 POM121 S269 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96I25 RBM17 S48 psp Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}.
Q96JM3 CHAMP1 S445 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96L91 EP400 S927 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96MU7 YTHDC1 S294 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q96NY8 NECTIN4 S432 ochoa Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; FUNCTION: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}.
Q96QT4 TRPM7 S1463 ochoa|psp Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q96R06 SPAG5 S397 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96RG2 PASK S935 ochoa PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.
Q96RR4 CAMKK2 S86 ochoa Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.
Q96RT1 ERBIN S1144 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96RT1 ERBIN S1165 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q99081 TCF12 S544 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99081 TCF12 S545 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99490 AGAP2 S634 ochoa Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.
Q99698 LYST S2152 ochoa Lysosomal-trafficking regulator (Beige homolog) Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}.
Q99708 RBBP8 S313 ochoa DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}.
Q9BSQ5 CCM2 S164 ochoa Cerebral cavernous malformations 2 protein (Malcavernin) Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BXL6 CARD14 S241 ochoa Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}.
Q9BZ95 NSD3 S571 ochoa Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.
Q9C0C2 TNKS1BP1 S962 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0D2 CEP295 S2009 ochoa Centrosomal protein of 295 kDa Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}.
Q9C0K0 BCL11B S775 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H165 BCL11A S594 ochoa BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.
Q9H6T3 RPAP3 S489 ochoa RNA polymerase II-associated protein 3 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}.
Q9H788 SH2D4A S261 ochoa SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}.
Q9H792 PEAK1 S1236 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9HB20 PLEKHA3 S230 ochoa Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}.
Q9HCD6 TANC2 S21 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9HCD6 TANC2 S254 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9NP61 ARFGAP3 S437 ochoa ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}.
Q9NPI1 BRD7 S265 ochoa Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.
Q9NSC5 HOMER3 S38 psp Homer protein homolog 3 (Homer-3) Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}.
Q9NTI5 PDS5B S1190 ochoa Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}.
Q9NTM9 CUTC S224 ochoa Copper homeostasis protein cutC homolog May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. {ECO:0000269|PubMed:16182249, ECO:0000269|PubMed:19878721}.
Q9NW75 GPATCH2 S115 ochoa G patch domain-containing protein 2 Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}.
Q9NWQ8 PAG1 S339 ochoa Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.
Q9NYV4 CDK12 Y319 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9P2F8 SIPA1L2 S148 ochoa Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) None
Q9UDY2 TJP2 S952 ochoa Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.
Q9UGU0 TCF20 S524 ochoa Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.
Q9UHB7 AFF4 S680 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UHR4 BAIAP2L1 S317 ochoa BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}.
Q9UHY8 FEZ2 S204 ochoa Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) Involved in axonal outgrowth and fasciculation. {ECO:0000250}.
Q9UI08 EVL S331 ochoa Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Q9UID3 VPS51 S649 ochoa Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}.
Q9UKE5 TNIK S750 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9ULC8 ZDHHC8 S629 ochoa Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}.
Q9ULD4 BRPF3 S886 ochoa Bromodomain and PHD finger-containing protein 3 Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}.
Q9ULF5 SLC39A10 S556 ochoa Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}.
Q9ULT8 HECTD1 S1529 ochoa E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}.
Q9UMZ2 SYNRG S1084 ochoa Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}.
Q9UNZ2 NSFL1C S60 ochoa NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
Q9UPQ0 LIMCH1 S212 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UPU5 USP24 S1285 ochoa Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}.
Q9UPU9 SAMD4A S651 ochoa Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}.
Q9UQ35 SRRM2 S2407 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y253 POLH S587 psp DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}.
Q9Y285 FARSA S184 ochoa Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) None
Q9Y2H0 DLGAP4 S651 ochoa Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Q9Y2H5 PLEKHA6 S441 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y3R5 DOP1B S1169 ochoa Protein DOP1B May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.
Q9Y446 PKP3 S121 ochoa Plakophilin-3 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}.
Q9Y4J8 DTNA S623 ochoa Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Q9Y608 LRRFIP2 S314 ochoa Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}.
Q9Y6X9 MORC2 S725 ochoa ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}.
P18754 RCC1 S90 Sugiyama Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}.
Q14247 CTTN S331 Sugiyama Src substrate cortactin (Amplaxin) (Oncogene EMS1) Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.
Q14671 PUM1 S183 Sugiyama Pumilio homolog 1 (HsPUM) (Pumilio-1) Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}.
P08195 SLC3A2 S513 Sugiyama Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}.
Q7Z2W4 ZC3HAV1 S364 Sugiyama Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
P31939 ATIC S300 Sugiyama Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}.
Q15084 PDIA6 S375 Sugiyama Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}.
P36888 FLT3 S735 Sugiyama Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}.
Q9C0C2 TNKS1BP1 S1173 Sugiyama 182 kDa tankyrase-1-binding protein None
Q8TDN4 CABLES1 S273 SIGNOR CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
P42566 EPS15 S655 Sugiyama Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
O75390 CS S83 Sugiyama Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}.
Q9BZL6 PRKD2 S183 Sugiyama Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}.
P83881 RPL36A S32 Sugiyama Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
Download
reactome_id name p -log10_p
R-HSA-2980766 Nuclear Envelope Breakdown 8.539768e-07 6.069
R-HSA-180746 Nuclear import of Rev protein 3.736541e-06 5.428
R-HSA-68882 Mitotic Anaphase 4.034912e-06 5.394
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.242497e-06 5.372
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 6.813122e-06 5.167
R-HSA-177243 Interactions of Rev with host cellular proteins 9.005072e-06 5.046
R-HSA-68886 M Phase 1.498171e-05 4.824
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.134040e-05 4.671
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.484068e-05 4.605
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.484068e-05 4.605
R-HSA-1855170 IPs transport between nucleus and cytosol 3.322582e-05 4.479
R-HSA-159227 Transport of the SLBP independent Mature mRNA 3.322582e-05 4.479
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.819596e-05 4.418
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.819596e-05 4.418
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 4.992246e-05 4.302
R-HSA-180910 Vpr-mediated nuclear import of PICs 6.436715e-05 4.191
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 6.857739e-05 4.164
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 8.196878e-05 4.086
R-HSA-168276 NS1 Mediated Effects on Host Pathways 8.196878e-05 4.086
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 9.210161e-05 4.036
R-HSA-176033 Interactions of Vpr with host cellular proteins 9.210161e-05 4.036
R-HSA-69278 Cell Cycle, Mitotic 9.803974e-05 4.009
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 1.032066e-04 3.986
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 1.418276e-04 3.848
R-HSA-1640170 Cell Cycle 1.308907e-04 3.883
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 1.757256e-04 3.755
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 1.941469e-04 3.712
R-HSA-68875 Mitotic Prophase 2.348839e-04 3.629
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.113076e-04 3.507
R-HSA-1169408 ISG15 antiviral mechanism 3.055063e-04 3.515
R-HSA-68877 Mitotic Prometaphase 4.415172e-04 3.355
R-HSA-2470946 Cohesin Loading onto Chromatin 5.060482e-04 3.296
R-HSA-194441 Metabolism of non-coding RNA 6.025399e-04 3.220
R-HSA-191859 snRNP Assembly 6.025399e-04 3.220
R-HSA-168325 Viral Messenger RNA Synthesis 7.012095e-04 3.154
R-HSA-6784531 tRNA processing in the nucleus 7.550084e-04 3.122
R-HSA-162599 Late Phase of HIV Life Cycle 8.288661e-04 3.082
R-HSA-352238 Breakdown of the nuclear lamina 9.904775e-04 3.004
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 1.075417e-03 2.968
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.153562e-03 2.938
R-HSA-9932444 ATP-dependent chromatin remodelers 1.350630e-03 2.869
R-HSA-9932451 SWI/SNF chromatin remodelers 1.350630e-03 2.869
R-HSA-163765 ChREBP activates metabolic gene expression 1.328381e-03 2.877
R-HSA-162909 Host Interactions of HIV factors 1.323776e-03 2.878
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.462371e-03 2.835
R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.416626e-03 2.849
R-HSA-75153 Apoptotic execution phase 1.485673e-03 2.828
R-HSA-5578749 Transcriptional regulation by small RNAs 1.486228e-03 2.828
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.581546e-03 2.801
R-HSA-68884 Mitotic Telophase/Cytokinesis 1.615875e-03 2.792
R-HSA-162587 HIV Life Cycle 1.531196e-03 2.815
R-HSA-70171 Glycolysis 1.642263e-03 2.785
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 1.814748e-03 2.741
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.662746e-03 2.575
R-HSA-4839726 Chromatin organization 2.887136e-03 2.540
R-HSA-168255 Influenza Infection 3.464648e-03 2.460
R-HSA-70326 Glucose metabolism 4.075218e-03 2.390
R-HSA-3371556 Cellular response to heat stress 4.784776e-03 2.320
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.334247e-03 2.273
R-HSA-4419969 Depolymerization of the Nuclear Lamina 5.333457e-03 2.273
R-HSA-936837 Ion transport by P-type ATPases 5.038952e-03 2.298
R-HSA-8953750 Transcriptional Regulation by E2F6 5.497601e-03 2.260
R-HSA-9609690 HCMV Early Events 5.851750e-03 2.233
R-HSA-2467813 Separation of Sister Chromatids 6.935440e-03 2.159
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 8.257496e-03 2.083
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 8.257496e-03 2.083
R-HSA-5619102 SLC transporter disorders 7.610819e-03 2.119
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 8.374138e-03 2.077
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 8.399954e-03 2.076
R-HSA-9609646 HCMV Infection 8.570370e-03 2.067
R-HSA-211000 Gene Silencing by RNA 9.962936e-03 2.002
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 1.035832e-02 1.985
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.096120e-02 1.960
R-HSA-8863678 Neurodegenerative Diseases 1.096120e-02 1.960
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 1.230315e-02 1.910
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.230315e-02 1.910
R-HSA-1483249 Inositol phosphate metabolism 1.199745e-02 1.921
R-HSA-9702506 Drug resistance of FLT3 mutants 1.497753e-02 1.825
R-HSA-9702509 FLT3 mutants bind TKIs 1.497753e-02 1.825
R-HSA-9702624 sorafenib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702605 pexidartinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702590 gilteritinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702596 lestaurtinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702569 KW2449-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702620 quizartinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702600 midostaurin-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702632 sunitinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702998 linifanib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702577 semaxanib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702636 tandutinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9703009 tamatinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702614 ponatinib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-9702581 crenolanib-resistant FLT3 mutants 1.497753e-02 1.825
R-HSA-1221632 Meiotic synapsis 1.429237e-02 1.845
R-HSA-141424 Amplification of signal from the kinetochores 1.468834e-02 1.833
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.468834e-02 1.833
R-HSA-6802957 Oncogenic MAPK signaling 1.409041e-02 1.851
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.639995e-02 1.785
R-HSA-1500620 Meiosis 1.409041e-02 1.851
R-HSA-428543 Inactivation of CDC42 and RAC1 1.449842e-02 1.839
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 1.411907e-02 1.850
R-HSA-199991 Membrane Trafficking 1.361064e-02 1.866
R-HSA-162906 HIV Infection 1.357562e-02 1.867
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.645332e-02 1.784
R-HSA-177929 Signaling by EGFR 1.673041e-02 1.776
R-HSA-5578775 Ion homeostasis 1.673041e-02 1.776
R-HSA-9610379 HCMV Late Events 1.789326e-02 1.747
R-HSA-182971 EGFR downregulation 1.905234e-02 1.720
R-HSA-5633007 Regulation of TP53 Activity 1.941981e-02 1.712
R-HSA-376176 Signaling by ROBO receptors 2.055399e-02 1.687
R-HSA-5619115 Disorders of transmembrane transporters 2.123559e-02 1.673
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 2.199659e-02 1.658
R-HSA-418359 Reduction of cytosolic Ca++ levels 2.199659e-02 1.658
R-HSA-69618 Mitotic Spindle Checkpoint 2.756099e-02 1.560
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 2.770600e-02 1.557
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2.770600e-02 1.557
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 2.973164e-02 1.527
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 2.973164e-02 1.527
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 3.137889e-02 1.503
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 3.075960e-02 1.512
R-HSA-196780 Biotin transport and metabolism 3.393970e-02 1.469
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 3.393970e-02 1.469
R-HSA-418885 DCC mediated attractive signaling 3.393970e-02 1.469
R-HSA-3700989 Transcriptional Regulation by TP53 3.455773e-02 1.461
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.576206e-02 1.447
R-HSA-8856828 Clathrin-mediated endocytosis 3.667900e-02 1.436
R-HSA-3214841 PKMTs methylate histone lysines 3.692701e-02 1.433
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 3.770041e-02 1.424
R-HSA-5675221 Negative regulation of MAPK pathway 3.886239e-02 1.410
R-HSA-983712 Ion channel transport 3.993020e-02 1.399
R-HSA-3247509 Chromatin modifying enzymes 4.049491e-02 1.393
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 4.066173e-02 1.391
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 4.066173e-02 1.391
R-HSA-9675108 Nervous system development 4.161919e-02 1.381
R-HSA-2262752 Cellular responses to stress 4.324196e-02 1.364
R-HSA-2028269 Signaling by Hippo 4.419509e-02 1.355
R-HSA-176034 Interactions of Tat with host cellular proteins 4.426565e-02 1.354
R-HSA-3560792 Defective SLC26A2 causes chondrodysplasias 4.426565e-02 1.354
R-HSA-373752 Netrin-1 signaling 4.497148e-02 1.347
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 5.858284e-02 1.232
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 5.858284e-02 1.232
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 5.858284e-02 1.232
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 5.858284e-02 1.232
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 5.858284e-02 1.232
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 5.858284e-02 1.232
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 5.858284e-02 1.232
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 5.858284e-02 1.232
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 5.858284e-02 1.232
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 5.858284e-02 1.232
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 5.858284e-02 1.232
R-HSA-9665348 Signaling by ERBB2 ECD mutants 4.783780e-02 1.320
R-HSA-9709603 Impaired BRCA2 binding to PALB2 5.158582e-02 1.287
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 5.543521e-02 1.256
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 5.543521e-02 1.256
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 5.543521e-02 1.256
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 5.543521e-02 1.256
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 5.543521e-02 1.256
R-HSA-180292 GAB1 signalosome 4.783780e-02 1.320
R-HSA-5693538 Homology Directed Repair 5.118802e-02 1.291
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 5.858284e-02 1.232
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 5.152714e-02 1.288
R-HSA-422475 Axon guidance 4.986140e-02 1.302
R-HSA-381038 XBP1(S) activates chaperone genes 5.704219e-02 1.244
R-HSA-69620 Cell Cycle Checkpoints 6.194126e-02 1.208
R-HSA-8876384 Listeria monocytogenes entry into host cells 6.342278e-02 1.198
R-HSA-397014 Muscle contraction 6.396385e-02 1.194
R-HSA-432722 Golgi Associated Vesicle Biogenesis 6.593034e-02 1.181
R-HSA-5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) 7.268642e-02 1.139
R-HSA-9706374 FLT3 signaling through SRC family kinases 8.657957e-02 1.063
R-HSA-1251932 PLCG1 events in ERBB2 signaling 8.657957e-02 1.063
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 8.657957e-02 1.063
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 1.002654e-01 0.999
R-HSA-9706377 FLT3 signaling by CBL mutants 1.002654e-01 0.999
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 1.137470e-01 0.944
R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR 1.137470e-01 0.944
R-HSA-5603029 IkBA variant leads to EDA-ID 1.137470e-01 0.944
R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 1.137470e-01 0.944
R-HSA-8857538 PTK6 promotes HIF1A stabilization 1.270275e-01 0.896
R-HSA-9645135 STAT5 Activation 1.270275e-01 0.896
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 1.401097e-01 0.854
R-HSA-9732724 IFNG signaling activates MAPKs 1.401097e-01 0.854
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 1.401097e-01 0.854
R-HSA-446107 Type I hemidesmosome assembly 1.529967e-01 0.815
R-HSA-212718 EGFR interacts with phospholipase C-gamma 1.529967e-01 0.815
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 1.529967e-01 0.815
R-HSA-9660537 Signaling by MRAS-complex mutants 1.529967e-01 0.815
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.529967e-01 0.815
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 1.656913e-01 0.781
R-HSA-9700645 ALK mutants bind TKIs 1.656913e-01 0.781
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.905149e-01 0.720
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.905149e-01 0.720
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.905149e-01 0.720
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 7.607111e-02 1.119
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 2.026494e-01 0.693
R-HSA-5339716 Signaling by GSK3beta mutants 2.026494e-01 0.693
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 8.045102e-02 1.094
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 8.490721e-02 1.071
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 2.146028e-01 0.668
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 2.146028e-01 0.668
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 2.146028e-01 0.668
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 2.146028e-01 0.668
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 2.146028e-01 0.668
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 9.870144e-02 1.006
R-HSA-9709570 Impaired BRCA2 binding to RAD51 9.870144e-02 1.006
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 2.379768e-01 0.623
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 2.494027e-01 0.603
R-HSA-180336 SHC1 events in EGFR signaling 2.494027e-01 0.603
R-HSA-196299 Beta-catenin phosphorylation cascade 2.494027e-01 0.603
R-HSA-6785631 ERBB2 Regulates Cell Motility 2.494027e-01 0.603
R-HSA-390522 Striated Muscle Contraction 1.229298e-01 0.910
R-HSA-9706369 Negative regulation of FLT3 2.606580e-01 0.584
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 2.606580e-01 0.584
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 2.606580e-01 0.584
R-HSA-9607240 FLT3 Signaling 1.641625e-01 0.785
R-HSA-9656223 Signaling by RAF1 mutants 1.694790e-01 0.771
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.249560e-01 0.903
R-HSA-9649948 Signaling downstream of RAS mutants 1.964534e-01 0.707
R-HSA-8957275 Post-translational protein phosphorylation 8.445524e-02 1.073
R-HSA-380287 Centrosome maturation 1.316581e-01 0.881
R-HSA-112382 Formation of RNA Pol II elongation complex 2.294368e-01 0.639
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.817107e-01 0.741
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.930380e-01 0.714
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.968528e-01 0.706
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 2.122889e-01 0.673
R-HSA-192823 Viral mRNA Translation 2.478801e-01 0.606
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.680372e-01 0.572
R-HSA-5693607 Processing of DNA double-strand break ends 1.524817e-01 0.817
R-HSA-1227990 Signaling by ERBB2 in Cancer 1.034311e-01 0.985
R-HSA-9664565 Signaling by ERBB2 KD Mutants 9.870144e-02 1.006
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 2.379768e-01 0.623
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 1.279358e-01 0.893
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 1.964534e-01 0.707
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 1.964534e-01 0.707
R-HSA-5674135 MAP2K and MAPK activation 1.694790e-01 0.771
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 1.742633e-01 0.759
R-HSA-9682385 FLT3 signaling in disease 1.380867e-01 0.860
R-HSA-9762292 Regulation of CDH11 function 1.781964e-01 0.749
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1.905149e-01 0.720
R-HSA-156902 Peptide chain elongation 1.817107e-01 0.741
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 1.279358e-01 0.893
R-HSA-6802949 Signaling by RAS mutants 1.964534e-01 0.707
R-HSA-9842860 Regulation of endogenous retroelements 2.438768e-01 0.613
R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 1.002654e-01 0.999
R-HSA-5673000 RAF activation 1.279358e-01 0.893
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 2.026494e-01 0.693
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 2.717452e-01 0.566
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 1.247941e-01 0.904
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 2.161890e-01 0.665
R-HSA-165158 Activation of AKT2 1.002654e-01 0.999
R-HSA-2025928 Calcineurin activates NFAT 1.656913e-01 0.781
R-HSA-179812 GRB2 events in EGFR signaling 2.146028e-01 0.668
R-HSA-354192 Integrin signaling 1.179737e-01 0.928
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 1.179737e-01 0.928
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.432268e-01 0.844
R-HSA-9646399 Aggrephagy 1.588768e-01 0.799
R-HSA-75955 RNA Polymerase II Transcription Elongation 2.349752e-01 0.629
R-HSA-9614085 FOXO-mediated transcription 2.319338e-01 0.635
R-HSA-5693537 Resolution of D-Loop Structures 1.229298e-01 0.910
R-HSA-9614399 Regulation of localization of FOXO transcription factors 1.905149e-01 0.720
R-HSA-72764 Eukaryotic Translation Termination 2.161890e-01 0.665
R-HSA-76009 Platelet Aggregation (Plug Formation) 1.910128e-01 0.719
R-HSA-674695 RNA Polymerase II Pre-transcription Events 1.282912e-01 0.892
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 1.179737e-01 0.928
R-HSA-6807878 COPI-mediated anterograde transport 8.020242e-02 1.096
R-HSA-5621575 CD209 (DC-SIGN) signaling 7.607111e-02 1.119
R-HSA-5685942 HDR through Homologous Recombination (HRR) 1.056458e-01 0.976
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 8.943644e-02 1.048
R-HSA-5693532 DNA Double-Strand Break Repair 1.187630e-01 0.925
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.656913e-01 0.781
R-HSA-2179392 EGFR Transactivation by Gastrin 1.781964e-01 0.749
R-HSA-4839744 Signaling by APC mutants 1.905149e-01 0.720
R-HSA-209560 NF-kB is activated and signals survival 2.026494e-01 0.693
R-HSA-202670 ERKs are inactivated 2.026494e-01 0.693
R-HSA-4839735 Signaling by AXIN mutants 2.026494e-01 0.693
R-HSA-4839748 Signaling by AMER1 mutants 2.026494e-01 0.693
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 2.146028e-01 0.668
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 2.494027e-01 0.603
R-HSA-9603798 Class I peroxisomal membrane protein import 2.606580e-01 0.584
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 1.279358e-01 0.893
R-HSA-1963640 GRB2 events in ERBB2 signaling 2.717452e-01 0.566
R-HSA-109704 PI3K Cascade 2.183889e-01 0.661
R-HSA-9764561 Regulation of CDH1 Function 2.571904e-01 0.590
R-HSA-72689 Formation of a pool of free 40S subunits 2.161890e-01 0.665
R-HSA-156842 Eukaryotic Translation Elongation 2.006859e-01 0.697
R-HSA-8863795 Downregulation of ERBB2 signaling 1.034311e-01 0.985
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 1.179737e-01 0.928
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.632622e-01 0.787
R-HSA-202403 TCR signaling 1.146598e-01 0.941
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 2.494027e-01 0.603
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 1.484067e-01 0.829
R-HSA-912446 Meiotic recombination 2.239075e-01 0.650
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 1.082216e-01 0.966
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 2.683155e-01 0.571
R-HSA-5602358 Diseases associated with the TLR signaling cascade 1.588768e-01 0.799
R-HSA-5260271 Diseases of Immune System 1.588768e-01 0.799
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 2.429406e-01 0.614
R-HSA-5674499 Negative feedback regulation of MAPK pathway 1.137470e-01 0.944
R-HSA-1296052 Ca2+ activated K+ channels 1.401097e-01 0.854
R-HSA-8964046 VLDL clearance 1.401097e-01 0.854
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 2.379768e-01 0.623
R-HSA-3214847 HATs acetylate histones 8.662239e-02 1.062
R-HSA-112399 IRS-mediated signalling 2.571904e-01 0.590
R-HSA-6794361 Neurexins and neuroligins 2.294368e-01 0.639
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 2.073899e-01 0.683
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 1.529967e-01 0.815
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 1.536241e-01 0.814
R-HSA-9766229 Degradation of CDH1 2.128825e-01 0.672
R-HSA-9818749 Regulation of NFE2L2 gene expression 1.270275e-01 0.896
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 1.329889e-01 0.876
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 2.717452e-01 0.566
R-HSA-2408557 Selenocysteine synthesis 2.398842e-01 0.620
R-HSA-9009391 Extra-nuclear estrogen signaling 2.398842e-01 0.620
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 2.599486e-01 0.585
R-HSA-5218920 VEGFR2 mediated vascular permeability 1.641625e-01 0.785
R-HSA-389356 Co-stimulation by CD28 2.073899e-01 0.683
R-HSA-199977 ER to Golgi Anterograde Transport 1.064426e-01 0.973
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 1.002654e-01 0.999
R-HSA-9667769 Acetylcholine inhibits contraction of outer hair cells 1.137470e-01 0.944
R-HSA-5660668 CLEC7A/inflammasome pathway 1.137470e-01 0.944
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 1.401097e-01 0.854
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 1.401097e-01 0.854
R-HSA-444257 RSK activation 1.529967e-01 0.815
R-HSA-198693 AKT phosphorylates targets in the nucleus 1.656913e-01 0.781
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 7.177082e-02 1.144
R-HSA-428540 Activation of RAC1 2.026494e-01 0.693
R-HSA-8951936 RUNX3 regulates p14-ARF 2.146028e-01 0.668
R-HSA-418457 cGMP effects 2.379768e-01 0.623
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 2.606580e-01 0.584
R-HSA-69473 G2/M DNA damage checkpoint 1.282912e-01 0.892
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 2.516302e-01 0.599
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 2.518936e-01 0.599
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1.781964e-01 0.749
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 2.374081e-01 0.625
R-HSA-1474165 Reproduction 7.195374e-02 1.143
R-HSA-430116 GP1b-IX-V activation signalling 1.656913e-01 0.781
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 2.146028e-01 0.668
R-HSA-5653656 Vesicle-mediated transport 7.910809e-02 1.102
R-HSA-9645723 Diseases of programmed cell death 1.817107e-01 0.741
R-HSA-446728 Cell junction organization 1.667490e-01 0.778
R-HSA-9675135 Diseases of DNA repair 1.964534e-01 0.707
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 1.002654e-01 0.999
R-HSA-9764302 Regulation of CDH19 Expression and Function 1.137470e-01 0.944
R-HSA-448706 Interleukin-1 processing 1.656913e-01 0.781
R-HSA-193692 Regulated proteolysis of p75NTR 1.656913e-01 0.781
R-HSA-427601 Inorganic anion exchange by SLC26 transporters 1.905149e-01 0.720
R-HSA-446353 Cell-extracellular matrix interactions 2.494027e-01 0.603
R-HSA-174362 Transport and metabolism of PAPS 2.494027e-01 0.603
R-HSA-9930044 Nuclear RNA decay 1.179737e-01 0.928
R-HSA-2219528 PI3K/AKT Signaling in Cancer 1.406746e-01 0.852
R-HSA-1500931 Cell-Cell communication 2.467094e-01 0.608
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 2.717452e-01 0.566
R-HSA-5576891 Cardiac conduction 1.835417e-01 0.736
R-HSA-5607764 CLEC7A (Dectin-1) signaling 2.201041e-01 0.657
R-HSA-8953854 Metabolism of RNA 1.526377e-01 0.816
R-HSA-3323169 Defects in biotin (Btn) metabolism 1.656913e-01 0.781
R-HSA-442380 Zinc influx into cells by the SLC39 gene family 1.656913e-01 0.781
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 7.177082e-02 1.144
R-HSA-948021 Transport to the Golgi and subsequent modification 2.429562e-01 0.614
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.216529e-01 0.915
R-HSA-193639 p75NTR signals via NF-kB 2.494027e-01 0.603
R-HSA-74160 Gene expression (Transcription) 1.436408e-01 0.843
R-HSA-447043 Neurofascin interactions 1.270275e-01 0.896
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 2.494027e-01 0.603
R-HSA-193648 NRAGE signals death through JNK 7.375020e-02 1.132
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.680372e-01 0.572
R-HSA-9700206 Signaling by ALK in cancer 2.680372e-01 0.572
R-HSA-420597 Nectin/Necl trans heterodimerization 1.002654e-01 0.999
R-HSA-418360 Platelet calcium homeostasis 9.870144e-02 1.006
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 2.494027e-01 0.603
R-HSA-8963896 HDL assembly 2.379768e-01 0.623
R-HSA-69242 S Phase 1.084502e-01 0.965
R-HSA-162582 Signal Transduction 1.443476e-01 0.841
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1.656913e-01 0.781
R-HSA-2559583 Cellular Senescence 1.841898e-01 0.735
R-HSA-163685 Integration of energy metabolism 2.017734e-01 0.695
R-HSA-418346 Platelet homeostasis 1.049087e-01 0.979
R-HSA-8953897 Cellular responses to stimuli 7.654055e-02 1.116
R-HSA-193704 p75 NTR receptor-mediated signalling 8.662239e-02 1.062
R-HSA-435354 Zinc transporters 2.379768e-01 0.623
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.742633e-01 0.759
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 9.349105e-02 1.029
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 1.273855e-01 0.895
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 2.571904e-01 0.590
R-HSA-6804757 Regulation of TP53 Degradation 1.380867e-01 0.860
R-HSA-416482 G alpha (12/13) signalling events 1.419406e-01 0.848
R-HSA-9705683 SARS-CoV-2-host interactions 8.400866e-02 1.076
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.249560e-01 0.903
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.454265e-01 0.837
R-HSA-6806003 Regulation of TP53 Expression and Degradation 1.536241e-01 0.814
R-HSA-913531 Interferon Signaling 2.677875e-01 0.572
R-HSA-381070 IRE1alpha activates chaperones 6.810947e-02 1.167
R-HSA-5357801 Programmed Cell Death 1.274397e-01 0.895
R-HSA-109581 Apoptosis 1.384358e-01 0.859
R-HSA-73887 Death Receptor Signaling 2.625527e-01 0.581
R-HSA-9694516 SARS-CoV-2 Infection 1.969273e-01 0.706
R-HSA-381119 Unfolded Protein Response (UPR) 2.110862e-01 0.676
R-HSA-9679506 SARS-CoV Infections 2.554335e-01 0.593
R-HSA-72306 tRNA processing 6.859342e-02 1.164
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.720927e-01 0.565
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.720927e-01 0.565
R-HSA-1227986 Signaling by ERBB2 2.738778e-01 0.562
R-HSA-450294 MAP kinase activation 2.794383e-01 0.554
R-HSA-2428928 IRS-related events triggered by IGF1R 2.794383e-01 0.554
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 2.802233e-01 0.552
R-HSA-166166 MyD88-independent TLR4 cascade 2.802233e-01 0.552
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 2.826668e-01 0.549
R-HSA-5637810 Constitutive Signaling by EGFRvIII 2.826668e-01 0.549
R-HSA-5637812 Signaling by EGFRvIII in Cancer 2.826668e-01 0.549
R-HSA-1963642 PI3K events in ERBB2 signaling 2.826668e-01 0.549
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 2.849958e-01 0.545
R-HSA-9707616 Heme signaling 2.849958e-01 0.545
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 2.849958e-01 0.545
R-HSA-9824446 Viral Infection Pathways 2.851469e-01 0.545
R-HSA-927802 Nonsense-Mediated Decay (NMD) 2.883762e-01 0.540
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2.883762e-01 0.540
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 2.905492e-01 0.537
R-HSA-380259 Loss of Nlp from mitotic centrosomes 2.905492e-01 0.537
R-HSA-418990 Adherens junctions interactions 2.913507e-01 0.536
R-HSA-9614657 FOXO-mediated transcription of cell death genes 2.934253e-01 0.533
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 2.934253e-01 0.533
R-HSA-9613829 Chaperone Mediated Autophagy 2.934253e-01 0.533
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 2.934253e-01 0.533
R-HSA-432142 Platelet sensitization by LDL 2.934253e-01 0.533
R-HSA-3928664 Ephrin signaling 2.934253e-01 0.533
R-HSA-2428924 IGF1R signaling cascade 2.960973e-01 0.529
R-HSA-74751 Insulin receptor signalling cascade 2.960973e-01 0.529
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 3.016391e-01 0.521
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 3.016391e-01 0.521
R-HSA-110320 Translesion Synthesis by POLH 3.040230e-01 0.517
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 3.040230e-01 0.517
R-HSA-392517 Rap1 signalling 3.040230e-01 0.517
R-HSA-844456 The NLRP3 inflammasome 3.040230e-01 0.517
R-HSA-8854518 AURKA Activation by TPX2 3.071735e-01 0.513
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 3.071735e-01 0.513
R-HSA-5693606 DNA Double Strand Break Response 3.126994e-01 0.505
R-HSA-72613 Eukaryotic Translation Initiation 3.129272e-01 0.505
R-HSA-72737 Cap-dependent Translation Initiation 3.129272e-01 0.505
R-HSA-373760 L1CAM interactions 3.129272e-01 0.505
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 3.144625e-01 0.502
R-HSA-389513 Co-inhibition by CTLA4 3.144625e-01 0.502
R-HSA-140875 Common Pathway of Fibrin Clot Formation 3.144625e-01 0.502
R-HSA-445144 Signal transduction by L1 3.144625e-01 0.502
R-HSA-6807004 Negative regulation of MET activity 3.144625e-01 0.502
R-HSA-1181150 Signaling by NODAL 3.144625e-01 0.502
R-HSA-167172 Transcription of the HIV genome 3.182160e-01 0.497
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 3.182160e-01 0.497
R-HSA-5683057 MAPK family signaling cascades 3.191182e-01 0.496
R-HSA-5621481 C-type lectin receptors (CLRs) 3.228586e-01 0.491
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 3.237222e-01 0.490
R-HSA-5673001 RAF/MAP kinase cascade 3.245491e-01 0.489
R-HSA-5602498 MyD88 deficiency (TLR2/4) 3.247460e-01 0.488
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 3.247460e-01 0.488
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 3.247460e-01 0.488
R-HSA-198753 ERK/MAPK targets 3.247460e-01 0.488
R-HSA-210991 Basigin interactions 3.247460e-01 0.488
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 3.252293e-01 0.488
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 3.252293e-01 0.488
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 3.292172e-01 0.483
R-HSA-448424 Interleukin-17 signaling 3.292172e-01 0.483
R-HSA-69202 Cyclin E associated events during G1/S transition 3.292172e-01 0.483
R-HSA-75105 Fatty acyl-CoA biosynthesis 3.292172e-01 0.483
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 3.296427e-01 0.482
R-HSA-9764265 Regulation of CDH1 Expression and Function 3.296427e-01 0.482
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 3.348759e-01 0.475
R-HSA-9671555 Signaling by PDGFR in disease 3.348759e-01 0.475
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 3.375319e-01 0.472
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 3.375319e-01 0.472
R-HSA-9924644 Developmental Lineages of the Mammary Gland 3.401696e-01 0.468
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 3.401696e-01 0.468
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 3.401696e-01 0.468
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.416306e-01 0.466
R-HSA-212436 Generic Transcription Pathway 3.425473e-01 0.465
R-HSA-5684996 MAPK1/MAPK3 signaling 3.430938e-01 0.465
R-HSA-6803529 FGFR2 alternative splicing 3.448544e-01 0.462
R-HSA-350054 Notch-HLH transcription pathway 3.448544e-01 0.462
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 3.448544e-01 0.462
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 3.448544e-01 0.462
R-HSA-8964038 LDL clearance 3.448544e-01 0.462
R-HSA-6809371 Formation of the cornified envelope 3.457277e-01 0.461
R-HSA-8939211 ESR-mediated signaling 3.471904e-01 0.459
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 3.546838e-01 0.450
R-HSA-200425 Carnitine shuttle 3.546838e-01 0.450
R-HSA-3000171 Non-integrin membrane-ECM interactions 3.564923e-01 0.448
R-HSA-73857 RNA Polymerase II Transcription 3.590768e-01 0.445
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 3.618904e-01 0.441
R-HSA-9020591 Interleukin-12 signaling 3.619018e-01 0.441
R-HSA-114608 Platelet degranulation 3.620893e-01 0.441
R-HSA-69481 G2/M Checkpoints 3.620893e-01 0.441
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 3.643663e-01 0.438
R-HSA-933542 TRAF6 mediated NF-kB activation 3.643663e-01 0.438
R-HSA-429947 Deadenylation of mRNA 3.643663e-01 0.438
R-HSA-8963898 Plasma lipoprotein assembly 3.643663e-01 0.438
R-HSA-69275 G2/M Transition 3.738426e-01 0.427
R-HSA-9839394 TGFBR3 expression 3.739042e-01 0.427
R-HSA-5218921 VEGFR2 mediated cell proliferation 3.739042e-01 0.427
R-HSA-199418 Negative regulation of the PI3K/AKT network 3.743213e-01 0.427
R-HSA-9659379 Sensory processing of sound 3.780256e-01 0.422
R-HSA-453274 Mitotic G2-G2/M phases 3.806363e-01 0.419
R-HSA-8868773 rRNA processing in the nucleus and cytosol 3.806363e-01 0.419
R-HSA-1643713 Signaling by EGFR in Cancer 3.832995e-01 0.416
R-HSA-9703465 Signaling by FLT3 fusion proteins 3.832995e-01 0.416
R-HSA-5689901 Metalloprotease DUBs 3.832995e-01 0.416
R-HSA-525793 Myogenesis 3.832995e-01 0.416
R-HSA-3295583 TRP channels 3.832995e-01 0.416
R-HSA-9909396 Circadian clock 3.865076e-01 0.413
R-HSA-421270 Cell-cell junction organization 3.887842e-01 0.410
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 3.905578e-01 0.408
R-HSA-168898 Toll-like Receptor Cascades 3.908123e-01 0.408
R-HSA-445095 Interaction between L1 and Ankyrins 3.925544e-01 0.406
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 3.925544e-01 0.406
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 3.925544e-01 0.406
R-HSA-8949613 Cristae formation 3.925544e-01 0.406
R-HSA-389357 CD28 dependent PI3K/Akt signaling 3.925544e-01 0.406
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3.925544e-01 0.406
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 3.925544e-01 0.406
R-HSA-1643685 Disease 3.983872e-01 0.400
R-HSA-72163 mRNA Splicing - Major Pathway 4.009654e-01 0.397
R-HSA-167287 HIV elongation arrest and recovery 4.016710e-01 0.396
R-HSA-167290 Pausing and recovery of HIV elongation 4.016710e-01 0.396
R-HSA-9619483 Activation of AMPK downstream of NMDARs 4.016710e-01 0.396
R-HSA-622312 Inflammasomes 4.016710e-01 0.396
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.045108e-01 0.393
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 4.077183e-01 0.390
R-HSA-6794362 Protein-protein interactions at synapses 4.097443e-01 0.387
R-HSA-9615710 Late endosomal microautophagy 4.106513e-01 0.387
R-HSA-5656169 Termination of translesion DNA synthesis 4.106513e-01 0.387
R-HSA-9759475 Regulation of CDH11 Expression and Function 4.106513e-01 0.387
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 4.106513e-01 0.387
R-HSA-420092 Glucagon-type ligand receptors 4.106513e-01 0.387
R-HSA-180024 DARPP-32 events 4.106513e-01 0.387
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 4.106513e-01 0.387
R-HSA-9948299 Ribosome-associated quality control 4.147091e-01 0.382
R-HSA-1250196 SHC1 events in ERBB2 signaling 4.194974e-01 0.377
R-HSA-438064 Post NMDA receptor activation events 4.253080e-01 0.371
R-HSA-447115 Interleukin-12 family signaling 4.253080e-01 0.371
R-HSA-5694530 Cargo concentration in the ER 4.282112e-01 0.368
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 4.282112e-01 0.368
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 4.289339e-01 0.368
R-HSA-9663891 Selective autophagy 4.304487e-01 0.366
R-HSA-1538133 G0 and Early G1 4.367948e-01 0.360
R-HSA-4791275 Signaling by WNT in cancer 4.367948e-01 0.360
R-HSA-72172 mRNA Splicing 4.379003e-01 0.359
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 4.406567e-01 0.356
R-HSA-202424 Downstream TCR signaling 4.406567e-01 0.356
R-HSA-1839124 FGFR1 mutant receptor activation 4.452500e-01 0.351
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 4.452500e-01 0.351
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 4.452500e-01 0.351
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 4.452500e-01 0.351
R-HSA-397795 G-protein beta:gamma signalling 4.452500e-01 0.351
R-HSA-5675482 Regulation of necroptotic cell death 4.452500e-01 0.351
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 4.535788e-01 0.343
R-HSA-5223345 Miscellaneous transport and binding events 4.535788e-01 0.343
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 4.535788e-01 0.343
R-HSA-74752 Signaling by Insulin receptor 4.557789e-01 0.341
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 4.557789e-01 0.341
R-HSA-76002 Platelet activation, signaling and aggregation 4.565819e-01 0.340
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 4.617831e-01 0.336
R-HSA-5686938 Regulation of TLR by endogenous ligand 4.617831e-01 0.336
R-HSA-9006925 Intracellular signaling by second messengers 4.655816e-01 0.332
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 4.657295e-01 0.332
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 4.698646e-01 0.328
R-HSA-3296482 Defects in vitamin and cofactor metabolism 4.698646e-01 0.328
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 4.698646e-01 0.328
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 4.706645e-01 0.327
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 4.735989e-01 0.325
R-HSA-3371511 HSF1 activation 4.778254e-01 0.321
R-HSA-111933 Calmodulin induced events 4.778254e-01 0.321
R-HSA-111997 CaM pathway 4.778254e-01 0.321
R-HSA-114604 GPVI-mediated activation cascade 4.778254e-01 0.321
R-HSA-69205 G1/S-Specific Transcription 4.778254e-01 0.321
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 4.778254e-01 0.321
R-HSA-8941326 RUNX2 regulates bone development 4.778254e-01 0.321
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 4.804525e-01 0.318
R-HSA-8878159 Transcriptional regulation by RUNX3 4.853048e-01 0.314
R-HSA-170834 Signaling by TGF-beta Receptor Complex 4.853048e-01 0.314
R-HSA-933541 TRAF6 mediated IRF7 activation 4.856670e-01 0.314
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 4.856670e-01 0.314
R-HSA-975871 MyD88 cascade initiated on plasma membrane 4.901291e-01 0.310
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 4.901291e-01 0.310
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 4.901291e-01 0.310
R-HSA-5213460 RIPK1-mediated regulated necrosis 4.933914e-01 0.307
R-HSA-9958790 SLC-mediated transport of inorganic anions 4.933914e-01 0.307
R-HSA-9711097 Cellular response to starvation 4.964050e-01 0.304
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 5.010003e-01 0.300
R-HSA-8964043 Plasma lipoprotein clearance 5.010003e-01 0.300
R-HSA-9006936 Signaling by TGFB family members 5.038978e-01 0.298
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 5.084953e-01 0.294
R-HSA-3371568 Attenuation phase 5.084953e-01 0.294
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 5.084953e-01 0.294
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 5.084953e-01 0.294
R-HSA-167169 HIV Transcription Elongation 5.084953e-01 0.294
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 5.084953e-01 0.294
R-HSA-71240 Tryptophan catabolism 5.084953e-01 0.294
R-HSA-202433 Generation of second messenger molecules 5.084953e-01 0.294
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.091404e-01 0.293
R-HSA-2559580 Oxidative Stress Induced Senescence 5.091404e-01 0.293
R-HSA-1483255 PI Metabolism 5.091404e-01 0.293
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 5.158782e-01 0.287
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 5.158782e-01 0.287
R-HSA-8853884 Transcriptional Regulation by VENTX 5.158782e-01 0.287
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 5.158782e-01 0.287
R-HSA-9694548 Maturation of spike protein 5.158782e-01 0.287
R-HSA-1257604 PIP3 activates AKT signaling 5.166032e-01 0.287
R-HSA-111885 Opioid Signalling 5.184715e-01 0.285
R-HSA-9860931 Response of endothelial cells to shear stress 5.184715e-01 0.285
R-HSA-2408522 Selenoamino acid metabolism 5.187101e-01 0.285
R-HSA-167161 HIV Transcription Initiation 5.231507e-01 0.281
R-HSA-75953 RNA Polymerase II Transcription Initiation 5.231507e-01 0.281
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 5.231507e-01 0.281
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 5.231507e-01 0.281
R-HSA-5655302 Signaling by FGFR1 in disease 5.231507e-01 0.281
R-HSA-72312 rRNA processing 5.283767e-01 0.277
R-HSA-111996 Ca-dependent events 5.303143e-01 0.275
R-HSA-379716 Cytosolic tRNA aminoacylation 5.303143e-01 0.275
R-HSA-9692914 SARS-CoV-1-host interactions 5.322462e-01 0.274
R-HSA-73776 RNA Polymerase II Promoter Escape 5.373708e-01 0.270
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 5.412794e-01 0.267
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 5.412794e-01 0.267
R-HSA-2672351 Stimuli-sensing channels 5.412794e-01 0.267
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5.440482e-01 0.264
R-HSA-69231 Cyclin D associated events in G1 5.443217e-01 0.264
R-HSA-69236 G1 Phase 5.443217e-01 0.264
R-HSA-3214858 RMTs methylate histone arginines 5.443217e-01 0.264
R-HSA-975155 MyD88 dependent cascade initiated on endosome 5.457507e-01 0.263
R-HSA-5678895 Defective CFTR causes cystic fibrosis 5.511686e-01 0.259
R-HSA-774815 Nucleosome assembly 5.511686e-01 0.259
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 5.511686e-01 0.259
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 5.511686e-01 0.259
R-HSA-1489509 DAG and IP3 signaling 5.511686e-01 0.259
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 5.511686e-01 0.259
R-HSA-5689880 Ub-specific processing proteases 5.546696e-01 0.256
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 5.579130e-01 0.253
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 5.579130e-01 0.253
R-HSA-9839373 Signaling by TGFBR3 5.579130e-01 0.253
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 5.633313e-01 0.249
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 5.645565e-01 0.248
R-HSA-9855142 Cellular responses to mechanical stimuli 5.676499e-01 0.246
R-HSA-9031628 NGF-stimulated transcription 5.711005e-01 0.243
R-HSA-425410 Metal ion SLC transporters 5.711005e-01 0.243
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 5.761948e-01 0.239
R-HSA-73893 DNA Damage Bypass 5.775466e-01 0.238
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 5.775466e-01 0.238
R-HSA-4420097 VEGFA-VEGFR2 Pathway 5.804209e-01 0.236
R-HSA-1266738 Developmental Biology 5.835483e-01 0.234
R-HSA-3371571 HSF1-dependent transactivation 5.901508e-01 0.229
R-HSA-1169091 Activation of NF-kappaB in B cells 5.901508e-01 0.229
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 5.963118e-01 0.225
R-HSA-5688426 Deubiquitination 5.971052e-01 0.224
R-HSA-388841 Regulation of T cell activation by CD28 family 5.999565e-01 0.222
R-HSA-445355 Smooth Muscle Contraction 6.023804e-01 0.220
R-HSA-8956320 Nucleotide biosynthesis 6.023804e-01 0.220
R-HSA-9012852 Signaling by NOTCH3 6.142466e-01 0.212
R-HSA-9734767 Developmental Cell Lineages 6.195758e-01 0.208
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 6.200468e-01 0.208
R-HSA-69206 G1/S Transition 6.248681e-01 0.204
R-HSA-194138 Signaling by VEGF 6.248681e-01 0.204
R-HSA-187037 Signaling by NTRK1 (TRKA) 6.363421e-01 0.196
R-HSA-352230 Amino acid transport across the plasma membrane 6.369312e-01 0.196
R-HSA-429914 Deadenylation-dependent mRNA decay 6.369312e-01 0.196
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 6.369312e-01 0.196
R-HSA-1660661 Sphingolipid de novo biosynthesis 6.423917e-01 0.192
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 6.423917e-01 0.192
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 6.423917e-01 0.192
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 6.423917e-01 0.192
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 6.423917e-01 0.192
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 6.423917e-01 0.192
R-HSA-2644603 Signaling by NOTCH1 in Cancer 6.423917e-01 0.192
R-HSA-379724 tRNA Aminoacylation 6.423917e-01 0.192
R-HSA-112043 PLC beta mediated events 6.477703e-01 0.189
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 6.523725e-01 0.186
R-HSA-1268020 Mitochondrial protein import 6.530684e-01 0.185
R-HSA-9616222 Transcriptional regulation of granulopoiesis 6.530684e-01 0.185
R-HSA-382551 Transport of small molecules 6.546582e-01 0.184
R-HSA-8856688 Golgi-to-ER retrograde transport 6.548536e-01 0.184
R-HSA-8848021 Signaling by PTK6 6.582871e-01 0.182
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 6.582871e-01 0.182
R-HSA-6790901 rRNA modification in the nucleus and cytosol 6.582871e-01 0.182
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 6.634276e-01 0.178
R-HSA-6805567 Keratinization 6.641803e-01 0.178
R-HSA-9018519 Estrogen-dependent gene expression 6.726086e-01 0.172
R-HSA-109582 Hemostasis 6.737168e-01 0.172
R-HSA-9958863 SLC-mediated transport of amino acids 6.783916e-01 0.169
R-HSA-112040 G-protein mediated events 6.783916e-01 0.169
R-HSA-73894 DNA Repair 6.808306e-01 0.167
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 6.832308e-01 0.165
R-HSA-5218859 Regulated Necrosis 6.832308e-01 0.165
R-HSA-9730414 MITF-M-regulated melanocyte development 6.841408e-01 0.165
R-HSA-1280215 Cytokine Signaling in Immune system 6.872634e-01 0.163
R-HSA-9006931 Signaling by Nuclear Receptors 6.874398e-01 0.163
R-HSA-1632852 Macroautophagy 6.896186e-01 0.161
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 6.926929e-01 0.159
R-HSA-195253 Degradation of beta-catenin by the destruction complex 6.926929e-01 0.159
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 6.926929e-01 0.159
R-HSA-9764560 Regulation of CDH1 Gene Transcription 6.926929e-01 0.159
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 6.973178e-01 0.157
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 7.018734e-01 0.154
R-HSA-2871837 FCERI mediated NF-kB activation 7.026997e-01 0.153
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 7.063608e-01 0.151
R-HSA-453279 Mitotic G1 phase and G1/S transition 7.090673e-01 0.149
R-HSA-1226099 Signaling by FGFR in disease 7.107808e-01 0.148
R-HSA-1236394 Signaling by ERBB4 7.107808e-01 0.148
R-HSA-71403 Citric acid cycle (TCA cycle) 7.151346e-01 0.146
R-HSA-166520 Signaling by NTRKs 7.153210e-01 0.145
R-HSA-8878171 Transcriptional regulation by RUNX1 7.188469e-01 0.143
R-HSA-597592 Post-translational protein modification 7.191630e-01 0.143
R-HSA-1980143 Signaling by NOTCH1 7.194231e-01 0.143
R-HSA-9679191 Potential therapeutics for SARS 7.214620e-01 0.142
R-HSA-9856651 MITF-M-dependent gene expression 7.214620e-01 0.142
R-HSA-9694635 Translation of Structural Proteins 7.236474e-01 0.140
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.244906e-01 0.140
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 7.274914e-01 0.138
R-HSA-5619084 ABC transporter disorders 7.278082e-01 0.138
R-HSA-216083 Integrin cell surface interactions 7.278082e-01 0.138
R-HSA-9609507 Protein localization 7.304645e-01 0.136
R-HSA-5654738 Signaling by FGFR2 7.359437e-01 0.133
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 7.359437e-01 0.133
R-HSA-6806834 Signaling by MET 7.359437e-01 0.133
R-HSA-9612973 Autophagy 7.392200e-01 0.131
R-HSA-977225 Amyloid fiber formation 7.399202e-01 0.131
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 7.438371e-01 0.129
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 7.449216e-01 0.128
R-HSA-390918 Peroxisomal lipid metabolism 7.514954e-01 0.124
R-HSA-5687128 MAPK6/MAPK4 signaling 7.552386e-01 0.122
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 7.589256e-01 0.120
R-HSA-212165 Epigenetic regulation of gene expression 7.618703e-01 0.118
R-HSA-1236974 ER-Phagosome pathway 7.731289e-01 0.112
R-HSA-373080 Class B/2 (Secretin family receptors) 7.765475e-01 0.110
R-HSA-1474244 Extracellular matrix organization 7.773169e-01 0.109
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.843716e-01 0.105
R-HSA-2682334 EPH-Ephrin signaling 7.864986e-01 0.104
R-HSA-9772573 Late SARS-CoV-2 Infection Events 7.864986e-01 0.104
R-HSA-9678108 SARS-CoV-1 Infection 7.915899e-01 0.101
R-HSA-9837999 Mitochondrial protein degradation 7.928862e-01 0.101
R-HSA-1474290 Collagen formation 7.928862e-01 0.101
R-HSA-446203 Asparagine N-linked glycosylation 8.001729e-01 0.097
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 8.021125e-01 0.096
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 8.021125e-01 0.096
R-HSA-1296071 Potassium Channels 8.021125e-01 0.096
R-HSA-190236 Signaling by FGFR 8.080348e-01 0.093
R-HSA-382556 ABC-family proteins mediated transport 8.137805e-01 0.089
R-HSA-5663205 Infectious disease 8.152987e-01 0.089
R-HSA-9020702 Interleukin-1 signaling 8.165888e-01 0.088
R-HSA-5617833 Cilium Assembly 8.245764e-01 0.084
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 8.286031e-01 0.082
R-HSA-1236975 Antigen processing-Cross presentation 8.375888e-01 0.077
R-HSA-389948 Co-inhibition by PD-1 8.438923e-01 0.074
R-HSA-6798695 Neutrophil degranulation 8.495860e-01 0.071
R-HSA-2871809 FCERI mediated Ca+2 mobilization 8.583640e-01 0.066
R-HSA-9007101 Rab regulation of trafficking 8.626086e-01 0.064
R-HSA-1592230 Mitochondrial biogenesis 8.626086e-01 0.064
R-HSA-112316 Neuronal System 8.628694e-01 0.064
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 8.661225e-01 0.062
R-HSA-8878166 Transcriptional regulation by RUNX2 8.667265e-01 0.062
R-HSA-73886 Chromosome Maintenance 8.707214e-01 0.060
R-HSA-9759194 Nuclear events mediated by NFE2L2 8.707214e-01 0.060
R-HSA-9816359 Maternal to zygotic transition (MZT) 8.745971e-01 0.058
R-HSA-1852241 Organelle biogenesis and maintenance 8.885177e-01 0.051
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.921380e-01 0.050
R-HSA-9843745 Adipogenesis 8.923069e-01 0.049
R-HSA-8957322 Metabolism of steroids 8.931128e-01 0.049
R-HSA-15869 Metabolism of nucleotides 8.997145e-01 0.046
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 9.031990e-01 0.044
R-HSA-157118 Signaling by NOTCH 9.044878e-01 0.044
R-HSA-72766 Translation 9.097687e-01 0.041
R-HSA-388396 GPCR downstream signalling 9.157983e-01 0.038
R-HSA-446652 Interleukin-1 family signaling 9.241500e-01 0.034
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 9.264289e-01 0.033
R-HSA-449147 Signaling by Interleukins 9.268727e-01 0.033
R-HSA-1989781 PPARA activates gene expression 9.275426e-01 0.033
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 9.297199e-01 0.032
R-HSA-877300 Interferon gamma signaling 9.318321e-01 0.031
R-HSA-9711123 Cellular response to chemical stress 9.324108e-01 0.030
R-HSA-418555 G alpha (s) signalling events 9.441014e-01 0.025
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 9.474141e-01 0.023
R-HSA-1483257 Phospholipid metabolism 9.518974e-01 0.021
R-HSA-425407 SLC-mediated transmembrane transport 9.524594e-01 0.021
R-HSA-201681 TCF dependent signaling in response to WNT 9.534642e-01 0.021
R-HSA-392499 Metabolism of proteins 9.539682e-01 0.020
R-HSA-3781865 Diseases of glycosylation 9.541699e-01 0.020
R-HSA-372790 Signaling by GPCR 9.568529e-01 0.019
R-HSA-8978868 Fatty acid metabolism 9.575642e-01 0.019
R-HSA-1630316 Glycosaminoglycan metabolism 9.600610e-01 0.018
R-HSA-1280218 Adaptive Immune System 9.635799e-01 0.016
R-HSA-428157 Sphingolipid metabolism 9.646609e-01 0.016
R-HSA-112315 Transmission across Chemical Synapses 9.663979e-01 0.015
R-HSA-8951664 Neddylation 9.743770e-01 0.011
R-HSA-202733 Cell surface interactions at the vascular wall 9.799495e-01 0.009
R-HSA-196854 Metabolism of vitamins and cofactors 9.803198e-01 0.009
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.848963e-01 0.007
R-HSA-9824439 Bacterial Infection Pathways 9.862398e-01 0.006
R-HSA-416476 G alpha (q) signalling events 9.867519e-01 0.006
R-HSA-71291 Metabolism of amino acids and derivatives 9.878491e-01 0.005
R-HSA-418594 G alpha (i) signalling events 9.890379e-01 0.005
R-HSA-9658195 Leishmania infection 9.897981e-01 0.004
R-HSA-9824443 Parasitic Infection Pathways 9.897981e-01 0.004
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 9.899538e-01 0.004
R-HSA-5668914 Diseases of metabolism 9.916261e-01 0.004
R-HSA-195721 Signaling by WNT 9.921461e-01 0.003
R-HSA-168249 Innate Immune System 9.931448e-01 0.003
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.959523e-01 0.002
R-HSA-168256 Immune System 9.973497e-01 0.001
R-HSA-556833 Metabolism of lipids 9.997900e-01 0.000
R-HSA-500792 GPCR ligand binding 9.999159e-01 0.000
R-HSA-9709957 Sensory Perception 9.999999e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.904 0.269 2 0.907
CLK3CLK3 0.898 0.342 1 0.853
CDC7CDC7 0.890 0.117 1 0.844
DSTYKDSTYK 0.889 0.158 2 0.920
MOSMOS 0.888 0.178 1 0.852
MTORMTOR 0.886 0.030 1 0.795
KISKIS 0.884 0.245 1 0.764
PIM3PIM3 0.883 0.093 -3 0.856
NLKNLK 0.882 0.152 1 0.869
PRPKPRPK 0.882 -0.088 -1 0.895
RAF1RAF1 0.881 -0.006 1 0.814
NDR2NDR2 0.880 0.052 -3 0.861
CAMK2GCAMK2G 0.880 0.020 2 0.850
BMPR1BBMPR1B 0.880 0.348 1 0.837
IKKBIKKB 0.879 -0.072 -2 0.756
GCN2GCN2 0.879 -0.111 2 0.815
SRPK1SRPK1 0.878 0.164 -3 0.769
GRK1GRK1 0.878 0.182 -2 0.827
CAMK1BCAMK1B 0.878 0.037 -3 0.894
NEK6NEK6 0.878 0.055 -2 0.900
CDKL1CDKL1 0.877 0.092 -3 0.825
BMPR2BMPR2 0.877 -0.011 -2 0.917
PDHK4PDHK4 0.877 -0.218 1 0.831
ATRATR 0.876 0.008 1 0.812
ERK5ERK5 0.876 0.075 1 0.820
TGFBR2TGFBR2 0.875 0.078 -2 0.875
CLK2CLK2 0.875 0.303 -3 0.771
RSK2RSK2 0.875 0.104 -3 0.789
TBK1TBK1 0.874 -0.116 1 0.708
GRK6GRK6 0.874 0.136 1 0.847
NEK7NEK7 0.874 -0.041 -3 0.905
ULK2ULK2 0.874 -0.137 2 0.798
TGFBR1TGFBR1 0.874 0.253 -2 0.869
GRK5GRK5 0.874 -0.005 -3 0.895
MST4MST4 0.873 0.054 2 0.880
SKMLCKSKMLCK 0.873 0.095 -2 0.877
HIPK4HIPK4 0.873 0.155 1 0.818
CDKL5CDKL5 0.872 0.094 -3 0.814
CDK8CDK8 0.871 0.182 1 0.755
IKKEIKKE 0.871 -0.126 1 0.703
PKN3PKN3 0.871 -0.001 -3 0.857
PIM1PIM1 0.871 0.099 -3 0.806
ICKICK 0.871 0.137 -3 0.859
ALK4ALK4 0.870 0.194 -2 0.893
PRKD1PRKD1 0.870 0.046 -3 0.835
DYRK2DYRK2 0.870 0.218 1 0.783
NIKNIK 0.870 -0.021 -3 0.916
CDK1CDK1 0.870 0.233 1 0.744
CAMK2BCAMK2B 0.870 0.130 2 0.829
DAPK2DAPK2 0.869 0.054 -3 0.903
FAM20CFAM20C 0.869 0.144 2 0.673
SRPK2SRPK2 0.869 0.132 -3 0.693
NDR1NDR1 0.869 -0.009 -3 0.859
PLK1PLK1 0.869 0.149 -2 0.867
CLK4CLK4 0.869 0.187 -3 0.798
PDHK1PDHK1 0.869 -0.239 1 0.805
NUAK2NUAK2 0.869 0.019 -3 0.874
P90RSKP90RSK 0.869 0.043 -3 0.794
CAMLCKCAMLCK 0.869 0.017 -2 0.867
IKKAIKKA 0.868 -0.003 -2 0.753
MLK1MLK1 0.868 -0.067 2 0.835
CDK19CDK19 0.868 0.193 1 0.724
JNK2JNK2 0.868 0.254 1 0.722
WNK1WNK1 0.868 -0.030 -2 0.878
CAMK2DCAMK2D 0.867 0.000 -3 0.876
ACVR2AACVR2A 0.867 0.231 -2 0.861
GRK7GRK7 0.867 0.188 1 0.784
ACVR2BACVR2B 0.867 0.238 -2 0.871
MAPKAPK2MAPKAPK2 0.867 0.077 -3 0.742
CHAK2CHAK2 0.866 -0.038 -1 0.864
PRKD2PRKD2 0.866 0.064 -3 0.786
ATMATM 0.866 0.034 1 0.754
RIPK3RIPK3 0.866 -0.097 3 0.737
PKN2PKN2 0.866 0.011 -3 0.876
CLK1CLK1 0.866 0.195 -3 0.772
HUNKHUNK 0.866 -0.093 2 0.832
GRK4GRK4 0.866 -0.017 -2 0.869
JNK3JNK3 0.866 0.226 1 0.745
CAMK2ACAMK2A 0.865 0.117 2 0.844
SRPK3SRPK3 0.865 0.116 -3 0.749
ALK2ALK2 0.865 0.213 -2 0.875
P70S6KBP70S6KB 0.865 0.033 -3 0.827
ULK1ULK1 0.865 -0.156 -3 0.865
PKCDPKCD 0.864 0.033 2 0.809
MAPKAPK3MAPKAPK3 0.864 0.003 -3 0.799
BCKDKBCKDK 0.864 -0.144 -1 0.855
DLKDLK 0.864 -0.044 1 0.824
MARK4MARK4 0.864 -0.054 4 0.796
LATS2LATS2 0.864 -0.020 -5 0.744
BMPR1ABMPR1A 0.863 0.278 1 0.813
LATS1LATS1 0.863 0.112 -3 0.869
AURCAURC 0.862 0.087 -2 0.673
PKACGPKACG 0.862 0.014 -2 0.761
NEK9NEK9 0.862 -0.123 2 0.846
CDK7CDK7 0.861 0.144 1 0.761
CDK18CDK18 0.861 0.208 1 0.703
CDK5CDK5 0.861 0.191 1 0.775
CDK13CDK13 0.861 0.153 1 0.735
RSK3RSK3 0.861 0.002 -3 0.784
ANKRD3ANKRD3 0.860 -0.111 1 0.822
MASTLMASTL 0.860 -0.276 -2 0.839
P38AP38A 0.860 0.201 1 0.775
P38BP38B 0.859 0.225 1 0.724
AMPKA1AMPKA1 0.859 -0.054 -3 0.883
RSK4RSK4 0.859 0.096 -3 0.758
HIPK2HIPK2 0.859 0.229 1 0.707
P38GP38G 0.859 0.213 1 0.664
DYRK4DYRK4 0.858 0.238 1 0.725
MSK1MSK1 0.857 0.070 -3 0.771
MSK2MSK2 0.857 -0.007 -3 0.766
DNAPKDNAPK 0.857 0.051 1 0.694
PKACBPKACB 0.857 0.097 -2 0.690
MLK3MLK3 0.857 -0.023 2 0.764
DRAK1DRAK1 0.856 0.125 1 0.817
CDK17CDK17 0.856 0.187 1 0.669
PKRPKR 0.856 -0.011 1 0.798
PRKXPRKX 0.856 0.139 -3 0.706
CDK2CDK2 0.856 0.123 1 0.813
HIPK1HIPK1 0.855 0.192 1 0.789
PLK3PLK3 0.855 0.008 2 0.811
MLK2MLK2 0.855 -0.154 2 0.831
WNK3WNK3 0.855 -0.308 1 0.774
ERK1ERK1 0.855 0.184 1 0.713
CAMK4CAMK4 0.855 -0.089 -3 0.859
YSK4YSK4 0.855 -0.071 1 0.747
PAK1PAK1 0.854 -0.015 -2 0.795
RIPK1RIPK1 0.854 -0.219 1 0.772
CDK3CDK3 0.854 0.201 1 0.683
TSSK2TSSK2 0.854 -0.060 -5 0.831
MEK1MEK1 0.854 -0.104 2 0.857
GRK2GRK2 0.854 0.079 -2 0.747
AURAAURA 0.854 0.059 -2 0.645
PKCGPKCG 0.853 -0.006 2 0.762
CDK12CDK12 0.853 0.149 1 0.715
PKCBPKCB 0.853 0.007 2 0.758
PKCAPKCA 0.852 0.011 2 0.749
AMPKA2AMPKA2 0.852 -0.050 -3 0.849
MYLK4MYLK4 0.852 0.029 -2 0.784
MLK4MLK4 0.852 -0.029 2 0.739
TTBK2TTBK2 0.852 -0.220 2 0.709
IRE1IRE1 0.852 -0.133 1 0.741
AURBAURB 0.851 0.036 -2 0.670
TSSK1TSSK1 0.851 -0.046 -3 0.895
PRP4PRP4 0.851 0.137 -3 0.798
CDK9CDK9 0.851 0.119 1 0.740
NIM1NIM1 0.851 -0.137 3 0.790
CDK14CDK14 0.851 0.186 1 0.742
QSKQSK 0.850 -0.032 4 0.765
P38DP38D 0.850 0.222 1 0.662
ERK2ERK2 0.850 0.132 1 0.748
NEK2NEK2 0.850 -0.103 2 0.823
PAK3PAK3 0.850 -0.084 -2 0.790
MNK2MNK2 0.850 -0.026 -2 0.800
TLK2TLK2 0.849 -0.047 1 0.771
PRKD3PRKD3 0.849 -0.014 -3 0.770
VRK2VRK2 0.849 -0.236 1 0.847
CDK16CDK16 0.849 0.207 1 0.678
CDK10CDK10 0.849 0.204 1 0.730
DYRK1ADYRK1A 0.849 0.136 1 0.797
AKT2AKT2 0.848 0.051 -3 0.715
DYRK1BDYRK1B 0.848 0.172 1 0.749
CK2A2CK2A2 0.848 0.205 1 0.758
PAK6PAK6 0.848 0.018 -2 0.708
QIKQIK 0.848 -0.134 -3 0.882
PASKPASK 0.847 0.123 -3 0.878
SMG1SMG1 0.847 -0.081 1 0.759
PKCHPKCH 0.847 -0.045 2 0.741
HIPK3HIPK3 0.847 0.139 1 0.776
BRAFBRAF 0.847 -0.030 -4 0.832
MARK3MARK3 0.847 -0.023 4 0.721
GSK3AGSK3A 0.847 0.172 4 0.559
PKG2PKG2 0.847 0.021 -2 0.690
PIM2PIM2 0.846 0.037 -3 0.772
MELKMELK 0.846 -0.089 -3 0.836
IRE2IRE2 0.846 -0.114 2 0.765
BRSK1BRSK1 0.846 -0.041 -3 0.823
MNK1MNK1 0.846 -0.011 -2 0.814
MEKK3MEKK3 0.846 -0.087 1 0.791
DYRK3DYRK3 0.846 0.147 1 0.787
SGK3SGK3 0.845 0.015 -3 0.790
SIKSIK 0.845 -0.051 -3 0.797
PKCZPKCZ 0.845 -0.076 2 0.795
GSK3BGSK3B 0.845 0.116 4 0.552
PHKG1PHKG1 0.845 -0.108 -3 0.858
PAK2PAK2 0.845 -0.085 -2 0.780
NUAK1NUAK1 0.845 -0.093 -3 0.822
PERKPERK 0.845 -0.100 -2 0.891
CHK1CHK1 0.844 -0.056 -3 0.838
MST3MST3 0.844 0.037 2 0.864
CK1ECK1E 0.844 0.040 -3 0.613
HRIHRI 0.843 -0.144 -2 0.897
CHAK1CHAK1 0.843 -0.196 2 0.777
MARK2MARK2 0.843 -0.067 4 0.677
GRK3GRK3 0.842 0.072 -2 0.708
TAO3TAO3 0.841 0.005 1 0.779
JNK1JNK1 0.841 0.177 1 0.717
PINK1PINK1 0.841 -0.122 1 0.809
TLK1TLK1 0.841 -0.067 -2 0.884
NEK5NEK5 0.841 -0.091 1 0.782
MEKK1MEKK1 0.841 -0.159 1 0.777
MARK1MARK1 0.841 -0.061 4 0.748
CK2A1CK2A1 0.841 0.203 1 0.746
ZAKZAK 0.841 -0.138 1 0.756
SMMLCKSMMLCK 0.841 -0.003 -3 0.851
MEK5MEK5 0.840 -0.248 2 0.840
CAMK1GCAMK1G 0.840 -0.057 -3 0.798
DCAMKL1DCAMKL1 0.840 -0.029 -3 0.810
BRSK2BRSK2 0.840 -0.137 -3 0.853
MEKK2MEKK2 0.839 -0.122 2 0.814
PKACAPKACA 0.839 0.055 -2 0.637
MAPKAPK5MAPKAPK5 0.838 -0.148 -3 0.754
GAKGAK 0.838 0.058 1 0.813
PLK4PLK4 0.838 -0.164 2 0.646
GCKGCK 0.836 0.072 1 0.800
CK1DCK1D 0.836 0.041 -3 0.567
SNRKSNRK 0.836 -0.249 2 0.701
WNK4WNK4 0.835 -0.176 -2 0.872
AKT1AKT1 0.834 0.027 -3 0.735
MPSK1MPSK1 0.834 0.004 1 0.741
DAPK3DAPK3 0.834 0.052 -3 0.832
MAKMAK 0.833 0.207 -2 0.789
NEK8NEK8 0.833 -0.135 2 0.836
CDK6CDK6 0.833 0.157 1 0.715
CAMKK1CAMKK1 0.833 -0.145 -2 0.755
DAPK1DAPK1 0.833 0.070 -3 0.818
NEK11NEK11 0.832 -0.164 1 0.775
DCAMKL2DCAMKL2 0.832 -0.075 -3 0.838
CDK4CDK4 0.832 0.157 1 0.705
MST2MST2 0.831 -0.031 1 0.794
P70S6KP70S6K 0.831 -0.052 -3 0.737
ERK7ERK7 0.831 0.055 2 0.567
TAO2TAO2 0.831 -0.086 2 0.867
PKCTPKCT 0.831 -0.078 2 0.748
CAMK1DCAMK1D 0.831 -0.010 -3 0.717
EEF2KEEF2K 0.831 0.005 3 0.848
LKB1LKB1 0.831 -0.089 -3 0.897
CK1A2CK1A2 0.831 0.023 -3 0.566
IRAK4IRAK4 0.829 -0.206 1 0.736
CAMKK2CAMKK2 0.829 -0.136 -2 0.753
PKCEPKCE 0.829 0.011 2 0.745
PKCIPKCI 0.829 -0.058 2 0.765
PLK2PLK2 0.828 0.005 -3 0.796
HPK1HPK1 0.828 0.017 1 0.780
TAK1TAK1 0.828 -0.048 1 0.789
TNIKTNIK 0.827 -0.000 3 0.885
PHKG2PHKG2 0.827 -0.112 -3 0.835
MOKMOK 0.827 0.158 1 0.779
CK1G1CK1G1 0.827 -0.055 -3 0.604
MINKMINK 0.826 -0.061 1 0.759
PAK5PAK5 0.826 -0.049 -2 0.650
SSTKSSTK 0.824 -0.110 4 0.757
HGKHGK 0.824 -0.075 3 0.875
NEK4NEK4 0.824 -0.169 1 0.748
TTBK1TTBK1 0.824 -0.246 2 0.633
SGK1SGK1 0.823 0.040 -3 0.626
PDK1PDK1 0.823 -0.168 1 0.756
PAK4PAK4 0.823 -0.038 -2 0.658
MST1MST1 0.823 -0.073 1 0.769
KHS2KHS2 0.822 0.048 1 0.776
LRRK2LRRK2 0.822 -0.166 2 0.867
MRCKAMRCKA 0.821 0.014 -3 0.786
PDHK3_TYRPDHK3_TYR 0.821 0.292 4 0.903
AKT3AKT3 0.821 0.028 -3 0.641
NEK1NEK1 0.820 -0.128 1 0.751
KHS1KHS1 0.820 -0.008 1 0.753
MEKK6MEKK6 0.820 -0.177 1 0.762
MRCKBMRCKB 0.820 0.012 -3 0.771
ROCK2ROCK2 0.819 0.029 -3 0.817
MAP3K15MAP3K15 0.819 -0.177 1 0.736
VRK1VRK1 0.819 -0.180 2 0.860
IRAK1IRAK1 0.819 -0.357 -1 0.785
SLKSLK 0.818 -0.091 -2 0.734
CHK2CHK2 0.818 -0.026 -3 0.658
LOKLOK 0.818 -0.104 -2 0.782
PKN1PKN1 0.818 -0.068 -3 0.758
SBKSBK 0.816 0.025 -3 0.584
PDHK4_TYRPDHK4_TYR 0.816 0.214 2 0.918
STK33STK33 0.815 -0.188 2 0.638
MAP2K6_TYRMAP2K6_TYR 0.815 0.204 -1 0.927
PBKPBK 0.814 -0.048 1 0.728
BMPR2_TYRBMPR2_TYR 0.813 0.191 -1 0.928
DMPK1DMPK1 0.813 0.058 -3 0.786
YSK1YSK1 0.813 -0.125 2 0.821
CAMK1ACAMK1A 0.813 -0.039 -3 0.672
MAP2K4_TYRMAP2K4_TYR 0.812 0.095 -1 0.921
MEK2MEK2 0.812 -0.289 2 0.815
TTKTTK 0.811 0.008 -2 0.887
BUB1BUB1 0.811 0.017 -5 0.785
OSR1OSR1 0.810 -0.048 2 0.813
PDHK1_TYRPDHK1_TYR 0.810 0.126 -1 0.939
TESK1_TYRTESK1_TYR 0.810 0.002 3 0.900
RIPK2RIPK2 0.810 -0.320 1 0.709
ROCK1ROCK1 0.806 0.005 -3 0.784
MAP2K7_TYRMAP2K7_TYR 0.805 -0.177 2 0.885
PKMYT1_TYRPKMYT1_TYR 0.804 -0.089 3 0.864
EPHA6EPHA6 0.804 0.090 -1 0.919
NEK3NEK3 0.804 -0.212 1 0.712
ALPHAK3ALPHAK3 0.803 -0.049 -1 0.827
TXKTXK 0.803 0.224 1 0.860
EPHB4EPHB4 0.803 0.082 -1 0.898
HASPINHASPIN 0.802 -0.038 -1 0.720
MYO3BMYO3B 0.802 -0.078 2 0.836
PINK1_TYRPINK1_TYR 0.802 -0.161 1 0.812
CRIKCRIK 0.801 -0.002 -3 0.720
LIMK2_TYRLIMK2_TYR 0.801 -0.042 -3 0.919
PKG1PKG1 0.800 -0.061 -2 0.603
BIKEBIKE 0.800 -0.035 1 0.689
CK1ACK1A 0.798 0.012 -3 0.474
MYO3AMYO3A 0.798 -0.118 1 0.750
YANK3YANK3 0.797 -0.092 2 0.431
TAO1TAO1 0.797 -0.133 1 0.694
ASK1ASK1 0.797 -0.226 1 0.721
RETRET 0.796 -0.147 1 0.768
EPHA4EPHA4 0.796 0.050 2 0.821
ABL2ABL2 0.793 0.001 -1 0.858
MST1RMST1R 0.792 -0.182 3 0.814
LIMK1_TYRLIMK1_TYR 0.792 -0.246 2 0.868
SRMSSRMS 0.791 0.015 1 0.844
FGRFGR 0.791 -0.077 1 0.830
EPHB1EPHB1 0.791 0.006 1 0.836
JAK3JAK3 0.790 -0.096 1 0.753
ITKITK 0.790 0.031 -1 0.839
INSRRINSRR 0.790 -0.040 3 0.735
EPHB2EPHB2 0.790 0.032 -1 0.880
CSF1RCSF1R 0.790 -0.126 3 0.794
YES1YES1 0.790 -0.065 -1 0.866
TYRO3TYRO3 0.789 -0.192 3 0.798
TYK2TYK2 0.789 -0.303 1 0.756
FERFER 0.789 -0.127 1 0.849
ROS1ROS1 0.789 -0.192 3 0.765
EPHB3EPHB3 0.789 -0.018 -1 0.882
DDR1DDR1 0.789 -0.200 4 0.808
ABL1ABL1 0.787 -0.049 -1 0.845
JAK2JAK2 0.787 -0.247 1 0.755
BLKBLK 0.787 0.033 -1 0.876
STLK3STLK3 0.786 -0.251 1 0.726
HCKHCK 0.786 -0.095 -1 0.865
LCKLCK 0.785 -0.019 -1 0.867
BMXBMX 0.785 0.019 -1 0.766
TNK2TNK2 0.785 -0.101 3 0.750
FGFR2FGFR2 0.784 -0.144 3 0.785
KITKIT 0.784 -0.125 3 0.794
KDRKDR 0.782 -0.124 3 0.749
EPHA7EPHA7 0.782 -0.019 2 0.816
FLT1FLT1 0.781 -0.044 -1 0.905
TECTEC 0.781 -0.045 -1 0.771
FYNFYN 0.781 0.033 -1 0.843
METMET 0.781 -0.084 3 0.785
AAK1AAK1 0.780 -0.003 1 0.589
PTK2PTK2 0.780 0.153 -1 0.855
PDGFRBPDGFRB 0.780 -0.214 3 0.803
MERTKMERTK 0.780 -0.087 3 0.773
NEK10_TYRNEK10_TYR 0.779 -0.175 1 0.631
TNNI3K_TYRTNNI3K_TYR 0.779 -0.104 1 0.773
EPHA3EPHA3 0.779 -0.083 2 0.789
TEKTEK 0.778 -0.201 3 0.721
EPHA5EPHA5 0.777 0.006 2 0.808
PTK2BPTK2B 0.777 0.027 -1 0.801
FLT3FLT3 0.777 -0.226 3 0.794
JAK1JAK1 0.776 -0.170 1 0.709
WEE1_TYRWEE1_TYR 0.776 -0.121 -1 0.786
AXLAXL 0.776 -0.194 3 0.768
NTRK1NTRK1 0.775 -0.190 -1 0.874
FGFR1FGFR1 0.775 -0.233 3 0.755
SYKSYK 0.775 0.111 -1 0.848
DDR2DDR2 0.775 -0.039 3 0.719
ERBB2ERBB2 0.774 -0.162 1 0.751
TNK1TNK1 0.774 -0.208 3 0.780
BTKBTK 0.774 -0.222 -1 0.794
FGFR3FGFR3 0.774 -0.149 3 0.753
EPHA8EPHA8 0.774 -0.028 -1 0.870
FRKFRK 0.772 -0.120 -1 0.881
CK1G3CK1G3 0.771 -0.041 -3 0.429
FLT4FLT4 0.771 -0.196 3 0.742
EPHA1EPHA1 0.771 -0.162 3 0.757
PTK6PTK6 0.770 -0.270 -1 0.758
PDGFRAPDGFRA 0.770 -0.331 3 0.801
ALKALK 0.770 -0.226 3 0.706
LTKLTK 0.770 -0.214 3 0.733
EGFREGFR 0.770 -0.064 1 0.671
LYNLYN 0.769 -0.129 3 0.709
NTRK3NTRK3 0.769 -0.151 -1 0.826
INSRINSR 0.768 -0.190 3 0.713
NTRK2NTRK2 0.768 -0.254 3 0.747
SRCSRC 0.767 -0.085 -1 0.834
MATKMATK 0.767 -0.140 -1 0.788
EPHA2EPHA2 0.765 -0.019 -1 0.846
CSKCSK 0.763 -0.177 2 0.811
FGFR4FGFR4 0.762 -0.123 -1 0.828
YANK2YANK2 0.761 -0.129 2 0.444
ERBB4ERBB4 0.761 -0.019 1 0.709
CK1G2CK1G2 0.759 -0.019 -3 0.524
IGF1RIGF1R 0.755 -0.159 3 0.649
MUSKMUSK 0.754 -0.178 1 0.655
ZAP70ZAP70 0.748 -0.003 -1 0.764
FESFES 0.743 -0.145 -1 0.737