Motif 48 (n=141)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A9YTQ3 | AHRR | S101 | ochoa | Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Class E basic helix-loop-helix protein 77) (bHLHe77) | Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}. |
| H0YC42 | None | S201 | ochoa | Tumor protein D52 | None |
| H3BQZ7 | HNRNPUL2-BSCL2 | S228 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00429 | DNM1L | S548 | ochoa | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| O00444 | PLK4 | S665 | ochoa | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| O15014 | ZNF609 | S842 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15061 | SYNM | S429 | ochoa|psp | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15069 | NACAD | S561 | ochoa | NAC-alpha domain-containing protein 1 | May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| O15078 | CEP290 | S1610 | ochoa | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}. |
| O15079 | SNPH | S204 | ochoa | Syntaphilin | Inhibits SNARE complex formation by absorbing free STX1A. {ECO:0000269|PubMed:10707983}. |
| O15234 | CASC3 | S363 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O43301 | HSPA12A | S23 | ochoa | Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A) | Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. {ECO:0000269|PubMed:30679749}. |
| O60336 | MAPKBP1 | S1283 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60566 | BUB1B | S574 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O75448 | MED24 | S431 | ochoa | Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}. |
| O75475 | PSIP1 | S177 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O94782 | USP1 | S313 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94788 | ALDH1A2 | S351 | ochoa | Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:29240402, PubMed:33565183). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable) (PubMed:33565183). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity). {ECO:0000250|UniProtKB:Q63639, ECO:0000269|PubMed:29240402, ECO:0000269|PubMed:33565183, ECO:0000305|PubMed:22075477}. |
| O95067 | CCNB2 | S92 | ochoa | G2/mitotic-specific cyclin-B2 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
| O95271 | TNKS | S218 | ochoa | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
| O95453 | PARN | S163 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O96013 | PAK4 | S104 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P08651 | NFIC | S194 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P15923 | TCF3 | S379 | ochoa|psp | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P16144 | ITGB4 | S1696 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17028 | ZNF24 | S63 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P19634 | SLC9A1 | S693 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P22415 | USF1 | S186 | psp | Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) | Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. |
| P28749 | RBL1 | S1041 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P29317 | EPHA2 | S277 | psp | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P31948 | STIP1 | S481 | ochoa | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P34932 | HSPA4 | S408 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P42575 | CASP2 | S340 | ochoa|psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
| P46109 | CRKL | S107 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P51948 | MNAT1 | S279 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P54725 | RAD23A | S205 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P55196 | AFDN | S1107 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| Q01082 | SPTBN1 | S2102 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01196 | RUNX1 | S435 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q01814 | ATP2B2 | S1201 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q03252 | LMNB2 | S541 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q08999 | RBL2 | S1112 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q0JRZ9 | FCHO2 | S394 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12802 | AKAP13 | S352 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13323 | BIK | S124 | psp | Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) | Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}. |
| Q13554 | CAMK2B | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13555 | CAMK2G | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13591 | SEMA5A | S1010 | ochoa | Semaphorin-5A (Semaphorin-F) (Sema F) | Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}. |
| Q13761 | RUNX3 | S397 | ochoa | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13950 | RUNX2 | S503 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14139 | UBE4A | S1034 | ochoa | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}. |
| Q14699 | RFTN1 | S220 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q16204 | CCDC6 | S244 | ochoa|psp | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16512 | PKN1 | S205 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q1KMD3 | HNRNPUL2 | S228 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2KHM9 | KIAA0753 | S826 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
| Q4KWH8 | PLCH1 | S1386 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q504Q3 | PAN2 | S791 | ochoa | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}. |
| Q5D0E6 | DALRD3 | S209 | ochoa | DALR anticodon-binding domain-containing protein 3 | Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B. {ECO:0000269|PubMed:32427860}. |
| Q5JSZ5 | PRRC2B | S1453 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5VV17 | OTUD1 | S216 | ochoa | OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7) | Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed:36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed:36445135). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:36445135}. |
| Q63ZY3 | KANK2 | S375 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q68DK2 | ZFYVE26 | S297 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q6PL18 | ATAD2 | S696 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6T4R5 | NHS | S571 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UWD8 | C16orf54 | S194 | ochoa | Transmembrane protein C16orf54 | None |
| Q6ZT07 | TBC1D9 | S471 | ochoa | TBC1 domain family member 9 (TBC1 domain family member 9A) | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6ZVH7 | ESPNL | S786 | ochoa | Espin-like protein | Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}. |
| Q711Q0 | CEFIP | S470 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q86TB3 | ALPK2 | S1698 | ochoa | Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) | Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}. |
| Q86UD0 | SAPCD2 | S284 | ochoa | Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) | Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}. |
| Q86W42 | THOC6 | S180 | ochoa | THO complex subunit 6 (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15998806, PubMed:17190602). Plays a role in apoptosis negative control involved in brain development (PubMed:15833825, PubMed:23621916). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23621916, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q86X51 | EZHIP | S387 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q8IV36 | HID1 | S679 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IV50 | LYSMD2 | S24 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
| Q8IVT2 | MISP | S575 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWE2 | FAM114A1 | S120 | ochoa | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | May play a role in neuronal cell development. {ECO:0000250}. |
| Q8IY92 | SLX4 | S884 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYD8 | FANCM | S1437 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IZ40 | RCOR2 | S63 | ochoa | REST corepressor 2 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q8IZD4 | DCP1B | S147 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8NCF5 | NFATC2IP | S300 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NFP9 | NBEA | S1321 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8TBE0 | BAHD1 | S44 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TC05 | MDM1 | S584 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TDJ6 | DMXL2 | S473 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TER5 | ARHGEF40 | S931 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q92766 | RREB1 | S161 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92997 | DVL3 | S421 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q969F9 | HPS3 | S462 | ochoa | BLOC-2 complex member HPS3 (Hermansky-Pudlak syndrome 3 protein) | Involved in early stages of melanosome biogenesis and maturation. {ECO:0000250|UniProtKB:Q91VB4}. |
| Q96E14 | RMI2 | S112 | psp | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082, ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}. |
| Q96G74 | OTUD5 | S508 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96JM7 | L3MBTL3 | S678 | ochoa | Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) | Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96MU7 | YTHDC1 | S146 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96N67 | DOCK7 | S946 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q99698 | LYST | S2217 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BRS8 | LARP6 | S51 | ochoa | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BSJ8 | ESYT1 | S1034 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BSL1 | UBAC1 | S98 | ochoa | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:15746103, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612}. |
| Q9BTC0 | DIDO1 | S805 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BTC8 | MTA3 | S457 | ochoa | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q9BTE3 | MCMBP | S298 | ochoa | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}. |
| Q9BUJ2 | HNRNPUL1 | S194 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}. |
| Q9BY89 | KIAA1671 | S749 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYB0 | SHANK3 | S366 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZ95 | NSD3 | S561 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9C0A6 | SETD5 | S1020 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0C2 | TNKS1BP1 | S672 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H211 | CDT1 | S372 | psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H4A3 | WNK1 | S1261 | ochoa|psp | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H972 | C14orf93 | S285 | ochoa | Uncharacterized protein C14orf93 | None |
| Q9NPI1 | BRD7 | S621 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NQX5 | NPDC1 | S229 | ochoa | Neural proliferation differentiation and control protein 1 (NPDC-1) | Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity). {ECO:0000250}. |
| Q9NRA8 | EIF4ENIF1 | S951 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NUL3 | STAU2 | S486 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NVH0 | EXD2 | S407 | ochoa | Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2) | Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). {ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:29335528, ECO:0000269|PubMed:31127291, ECO:0000269|PubMed:31255466}. |
| Q9NVH2 | INTS7 | S644 | ochoa | Integrator complex subunit 7 (Int7) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q9NZ56 | FMN2 | S400 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9P242 | NYAP2 | S413 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P246 | STIM2 | S640 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P266 | JCAD | S237 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P275 | USP36 | S429 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UKD1 | GMEB2 | S126 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9UKJ3 | GPATCH8 | S1035 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKK3 | PARP4 | S1186 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULD4 | BRPF3 | S19 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULI4 | KIF26A | S1262 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULJ3 | ZBTB21 | S605 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULU8 | CADPS | S91 | ochoa | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}. |
| Q9UMZ2 | SYNRG | S909 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UQ35 | SRRM2 | S297 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQM7 | CAMK2A | S234 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2H9 | MAST1 | S1413 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2W1 | THRAP3 | S535 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y6R9 | CCDC61 | S447 | ochoa | Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}. |
| P07737 | PFN1 | S28 | Sugiyama | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| P18827 | SDC1 | S233 | Sugiyama | Syndecan-1 (SYND1) (CD antigen CD138) | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18828, ECO:0000269|PubMed:22660413}. |
| P20020 | ATP2B1 | S1178 | ELM|iPTMNet|EPSD | Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) | Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511, ECO:0000269|PubMed:35358416}. |
| O43602 | DCX | S287 | SIGNOR|iPTMNet | Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}. |
| Q9UBE8 | NLK | S232 | Sugiyama | Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) | Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:12482967, PubMed:14960582, PubMed:15004007, PubMed:15764709, PubMed:20061393, PubMed:20874444, PubMed:21454679). Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 (PubMed:15004007, PubMed:15764709). Negative regulator of the canonical Wnt/beta-catenin signaling pathway (PubMed:12482967). Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 (PubMed:21454679). Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes (PubMed:12482967, PubMed:21454679). Negative regulator of the Notch signaling pathway (PubMed:20118921). Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 (PubMed:20118921). Negative regulator of the MYB family of transcription factors (PubMed:15082531). Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP (PubMed:15082531). Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself (PubMed:15082531). Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (PubMed:15004007, PubMed:15764709). Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes (PubMed:26588989). {ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582, ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15082531, ECO:0000269|PubMed:15764709, ECO:0000269|PubMed:20061393, ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613, ECO:0000269|PubMed:26588989}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.000009 | 5.042 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.000009 | 5.050 |
| R-HSA-5578775 | Ion homeostasis | 0.000003 | 5.458 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.000007 | 5.128 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.000030 | 4.520 |
| R-HSA-111933 | Calmodulin induced events | 0.000068 | 4.167 |
| R-HSA-111997 | CaM pathway | 0.000068 | 4.167 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.000149 | 3.826 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.000149 | 3.826 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.000149 | 3.826 |
| R-HSA-111996 | Ca-dependent events | 0.000137 | 3.863 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.000125 | 3.904 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.000180 | 3.746 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.000179 | 3.747 |
| R-HSA-9620244 | Long-term potentiation | 0.000252 | 3.599 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.000357 | 3.448 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.000443 | 3.354 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.000489 | 3.311 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.000595 | 3.226 |
| R-HSA-5576891 | Cardiac conduction | 0.000606 | 3.217 |
| R-HSA-112043 | PLC beta mediated events | 0.000593 | 3.227 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.000595 | 3.226 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000595 | 3.226 |
| R-HSA-5673000 | RAF activation | 0.000716 | 3.145 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.000853 | 3.069 |
| R-HSA-112040 | G-protein mediated events | 0.000859 | 3.066 |
| R-HSA-983712 | Ion channel transport | 0.000995 | 3.002 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.001376 | 2.861 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.001910 | 2.719 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.001957 | 2.709 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.001957 | 2.709 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.001957 | 2.709 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.001957 | 2.709 |
| R-HSA-3371556 | Cellular response to heat stress | 0.002097 | 2.678 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.002158 | 2.666 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.002687 | 2.571 |
| R-HSA-429947 | Deadenylation of mRNA | 0.003187 | 2.497 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.003863 | 2.413 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.003763 | 2.424 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.004321 | 2.364 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.004133 | 2.384 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.004321 | 2.364 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.004213 | 2.375 |
| R-HSA-74160 | Gene expression (Transcription) | 0.004552 | 2.342 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.004990 | 2.302 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.004887 | 2.311 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.005196 | 2.284 |
| R-HSA-111885 | Opioid Signalling | 0.005365 | 2.270 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.005380 | 2.269 |
| R-HSA-1538133 | G0 and Early G1 | 0.006126 | 2.213 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.005681 | 2.246 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.006528 | 2.185 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.007167 | 2.145 |
| R-HSA-4086398 | Ca2+ pathway | 0.008120 | 2.090 |
| R-HSA-397014 | Muscle contraction | 0.007559 | 2.122 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.008260 | 2.083 |
| R-HSA-212436 | Generic Transcription Pathway | 0.008683 | 2.061 |
| R-HSA-9659379 | Sensory processing of sound | 0.010342 | 1.985 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.010654 | 1.973 |
| R-HSA-1640170 | Cell Cycle | 0.011143 | 1.953 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.012469 | 1.904 |
| R-HSA-195721 | Signaling by WNT | 0.012371 | 1.908 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.011710 | 1.931 |
| R-HSA-69206 | G1/S Transition | 0.011872 | 1.925 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.012925 | 1.889 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.013316 | 1.876 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.016235 | 1.790 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.014977 | 1.825 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.014244 | 1.846 |
| R-HSA-69236 | G1 Phase | 0.014244 | 1.846 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.016235 | 1.790 |
| R-HSA-9945266 | Differentiation of T cells | 0.016235 | 1.790 |
| R-HSA-69275 | G2/M Transition | 0.014951 | 1.825 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.015605 | 1.807 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.014357 | 1.843 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.016418 | 1.785 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.017788 | 1.750 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.021074 | 1.676 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.024446 | 1.612 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.025435 | 1.595 |
| R-HSA-5545619 | XAV939 stabilizes AXIN | 0.028466 | 1.546 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.029601 | 1.529 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.031811 | 1.497 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.031811 | 1.497 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.032600 | 1.487 |
| R-HSA-3000170 | Syndecan interactions | 0.032278 | 1.491 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.028328 | 1.548 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.035284 | 1.452 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.038579 | 1.414 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.040451 | 1.393 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.043017 | 1.366 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.044115 | 1.355 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.044115 | 1.355 |
| R-HSA-380287 | Centrosome maturation | 0.046821 | 1.330 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.046995 | 1.328 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.056127 | 1.251 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.057381 | 1.241 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.054884 | 1.261 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.054884 | 1.261 |
| R-HSA-68877 | Mitotic Prometaphase | 0.055172 | 1.258 |
| R-HSA-205025 | NADE modulates death signalling | 0.056127 | 1.251 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.059917 | 1.222 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.054884 | 1.261 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.059981 | 1.222 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.061917 | 1.208 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.065102 | 1.186 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.065173 | 1.186 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.065173 | 1.186 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.065173 | 1.186 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.067962 | 1.168 |
| R-HSA-8875878 | MET promotes cell motility | 0.070431 | 1.152 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.071283 | 1.147 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.074132 | 1.130 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.074132 | 1.130 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.083006 | 1.081 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.083006 | 1.081 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.091795 | 1.037 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.091795 | 1.037 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.083006 | 1.081 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.075898 | 1.120 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.083006 | 1.081 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.083006 | 1.081 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.084340 | 1.074 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.083006 | 1.081 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.091795 | 1.037 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.074132 | 1.130 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.074700 | 1.127 |
| R-HSA-447043 | Neurofascin interactions | 0.083006 | 1.081 |
| R-HSA-422475 | Axon guidance | 0.097493 | 1.011 |
| R-HSA-73887 | Death Receptor Signaling | 0.085615 | 1.067 |
| R-HSA-877300 | Interferon gamma signaling | 0.092669 | 1.033 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.090801 | 1.042 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.098741 | 1.006 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.100501 | 0.998 |
| R-HSA-8875656 | MET receptor recycling | 0.100501 | 0.998 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.100501 | 0.998 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.100501 | 0.998 |
| R-HSA-418346 | Platelet homeostasis | 0.106239 | 0.974 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.109124 | 0.962 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.142801 | 0.845 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.142801 | 0.845 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.151021 | 0.821 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.167226 | 0.777 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.183124 | 0.737 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.183124 | 0.737 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.183124 | 0.737 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.190960 | 0.719 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.206408 | 0.685 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.214021 | 0.670 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.214021 | 0.670 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.214021 | 0.670 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.214021 | 0.670 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.221562 | 0.655 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.243757 | 0.613 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.243757 | 0.613 |
| R-HSA-72187 | mRNA 3'-end processing | 0.114303 | 0.942 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.258203 | 0.588 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.133398 | 0.875 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.286277 | 0.543 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.313296 | 0.504 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.313296 | 0.504 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.319890 | 0.495 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.183719 | 0.736 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.229171 | 0.640 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.229171 | 0.640 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.289483 | 0.538 |
| R-HSA-72086 | mRNA Capping | 0.286277 | 0.543 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.310714 | 0.508 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.272374 | 0.565 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.272374 | 0.565 |
| R-HSA-162592 | Integration of provirus | 0.134502 | 0.871 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.142801 | 0.845 |
| R-HSA-4641265 | Repression of WNT target genes | 0.142801 | 0.845 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.175213 | 0.756 |
| R-HSA-9664420 | Killing mechanisms | 0.175213 | 0.756 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.183124 | 0.737 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.313296 | 0.504 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.163229 | 0.787 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.265322 | 0.576 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.272374 | 0.565 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.222113 | 0.653 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.275286 | 0.560 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.131805 | 0.880 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.159162 | 0.798 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.198721 | 0.702 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.251014 | 0.600 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.272374 | 0.565 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.201064 | 0.697 |
| R-HSA-9694614 | Attachment and Entry | 0.229031 | 0.640 |
| R-HSA-9843745 | Adipogenesis | 0.169471 | 0.771 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.183124 | 0.737 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.272374 | 0.565 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.194101 | 0.712 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.142078 | 0.847 |
| R-HSA-2024096 | HS-GAG degradation | 0.306638 | 0.513 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.296571 | 0.528 |
| R-HSA-164843 | 2-LTR circle formation | 0.117664 | 0.929 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.134502 | 0.871 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.183124 | 0.737 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.221562 | 0.655 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.279359 | 0.554 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.293129 | 0.533 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.286277 | 0.543 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.215074 | 0.667 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.206408 | 0.685 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.221562 | 0.655 |
| R-HSA-428540 | Activation of RAC1 | 0.134502 | 0.871 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.134502 | 0.871 |
| R-HSA-163615 | PKA activation | 0.198721 | 0.702 |
| R-HSA-9839394 | TGFBR3 expression | 0.258203 | 0.588 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.143200 | 0.844 |
| R-HSA-4086400 | PCP/CE pathway | 0.201064 | 0.697 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.190632 | 0.720 |
| R-HSA-170968 | Frs2-mediated activation | 0.151021 | 0.821 |
| R-HSA-525793 | Myogenesis | 0.265322 | 0.576 |
| R-HSA-73894 | DNA Repair | 0.161641 | 0.791 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.167226 | 0.777 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.175213 | 0.756 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.279359 | 0.554 |
| R-HSA-9930044 | Nuclear RNA decay | 0.313296 | 0.504 |
| R-HSA-5689877 | Josephin domain DUBs | 0.117664 | 0.929 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.151021 | 0.821 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.190960 | 0.719 |
| R-HSA-2160916 | Hyaluronan degradation | 0.258203 | 0.588 |
| R-HSA-169893 | Prolonged ERK activation events | 0.175213 | 0.756 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.229031 | 0.640 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.258203 | 0.588 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.258203 | 0.588 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.221562 | 0.655 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.229031 | 0.640 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.126954 | 0.896 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.279359 | 0.554 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.299916 | 0.523 |
| R-HSA-6806834 | Signaling by MET | 0.208056 | 0.682 |
| R-HSA-9834899 | Specification of the neural plate border | 0.206408 | 0.685 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.279972 | 0.553 |
| R-HSA-186763 | Downstream signal transduction | 0.299916 | 0.523 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.236308 | 0.627 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.175213 | 0.756 |
| R-HSA-449836 | Other interleukin signaling | 0.206408 | 0.685 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.151021 | 0.821 |
| R-HSA-416700 | Other semaphorin interactions | 0.167226 | 0.777 |
| R-HSA-9833110 | RSV-host interactions | 0.307183 | 0.513 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.180277 | 0.744 |
| R-HSA-4839726 | Chromatin organization | 0.260905 | 0.584 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.173423 | 0.761 |
| R-HSA-9675108 | Nervous system development | 0.129155 | 0.889 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.139916 | 0.854 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.198721 | 0.702 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.313296 | 0.504 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.167223 | 0.777 |
| R-HSA-373753 | Nephrin family interactions | 0.214021 | 0.670 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.299916 | 0.523 |
| R-HSA-1989781 | PPARA activates gene expression | 0.233146 | 0.632 |
| R-HSA-69242 | S Phase | 0.215541 | 0.666 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.245878 | 0.609 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.206408 | 0.685 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.236429 | 0.626 |
| R-HSA-3000157 | Laminin interactions | 0.258203 | 0.588 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.201064 | 0.697 |
| R-HSA-162582 | Signal Transduction | 0.195649 | 0.709 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.238224 | 0.623 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.306638 | 0.513 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.183124 | 0.737 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.206408 | 0.685 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.178767 | 0.748 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.190155 | 0.721 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.285936 | 0.544 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.279682 | 0.553 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.324799 | 0.488 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.326421 | 0.486 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.326421 | 0.486 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.326421 | 0.486 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.326421 | 0.486 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.326421 | 0.486 |
| R-HSA-5617833 | Cilium Assembly | 0.326517 | 0.486 |
| R-HSA-112316 | Neuronal System | 0.331952 | 0.479 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.332890 | 0.478 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.332890 | 0.478 |
| R-HSA-187687 | Signalling to ERKs | 0.332890 | 0.478 |
| R-HSA-381042 | PERK regulates gene expression | 0.332890 | 0.478 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.332890 | 0.478 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.339298 | 0.469 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.339298 | 0.469 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.339298 | 0.469 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.339298 | 0.469 |
| R-HSA-8853659 | RET signaling | 0.339298 | 0.469 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.339298 | 0.469 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.342301 | 0.466 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.345644 | 0.461 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.345644 | 0.461 |
| R-HSA-4641257 | Degradation of AXIN | 0.345644 | 0.461 |
| R-HSA-4641258 | Degradation of DVL | 0.345644 | 0.461 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.345644 | 0.461 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.345644 | 0.461 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.345644 | 0.461 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.345644 | 0.461 |
| R-HSA-68886 | M Phase | 0.347245 | 0.459 |
| R-HSA-913531 | Interferon Signaling | 0.349145 | 0.457 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.351929 | 0.454 |
| R-HSA-373760 | L1CAM interactions | 0.356201 | 0.448 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.358155 | 0.446 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.358155 | 0.446 |
| R-HSA-5693538 | Homology Directed Repair | 0.363112 | 0.440 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.364321 | 0.439 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.364321 | 0.439 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.364321 | 0.439 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.364321 | 0.439 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.364321 | 0.439 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.364321 | 0.439 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.364321 | 0.439 |
| R-HSA-167169 | HIV Transcription Elongation | 0.364321 | 0.439 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.364321 | 0.439 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.370428 | 0.431 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.370428 | 0.431 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.370428 | 0.431 |
| R-HSA-382551 | Transport of small molecules | 0.371129 | 0.430 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.376477 | 0.424 |
| R-HSA-167161 | HIV Transcription Initiation | 0.376477 | 0.424 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.376477 | 0.424 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.376477 | 0.424 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.382469 | 0.417 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.388403 | 0.411 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.394280 | 0.404 |
| R-HSA-418594 | G alpha (i) signalling events | 0.394846 | 0.404 |
| R-HSA-68882 | Mitotic Anaphase | 0.396955 | 0.401 |
| R-HSA-114608 | Platelet degranulation | 0.397226 | 0.401 |
| R-HSA-69481 | G2/M Checkpoints | 0.397226 | 0.401 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.399535 | 0.398 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.400101 | 0.398 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.400101 | 0.398 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.400101 | 0.398 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.400101 | 0.398 |
| R-HSA-1500931 | Cell-Cell communication | 0.405624 | 0.392 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.405867 | 0.392 |
| R-HSA-9675135 | Diseases of DNA repair | 0.405867 | 0.392 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.405867 | 0.392 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.405867 | 0.392 |
| R-HSA-75153 | Apoptotic execution phase | 0.405867 | 0.392 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.411578 | 0.386 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.412425 | 0.385 |
| R-HSA-425410 | Metal ion SLC transporters | 0.417234 | 0.380 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.420607 | 0.376 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.420719 | 0.376 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.422836 | 0.374 |
| R-HSA-73893 | DNA Damage Bypass | 0.422836 | 0.374 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.433760 | 0.363 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.437024 | 0.359 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.439323 | 0.357 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.439323 | 0.357 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.439323 | 0.357 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.439323 | 0.357 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.439323 | 0.357 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.439323 | 0.357 |
| R-HSA-8953854 | Metabolism of RNA | 0.441727 | 0.355 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.442889 | 0.354 |
| R-HSA-6807070 | PTEN Regulation | 0.443521 | 0.353 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.444714 | 0.352 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.444714 | 0.352 |
| R-HSA-1221632 | Meiotic synapsis | 0.444714 | 0.352 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.444714 | 0.352 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.455342 | 0.342 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.455342 | 0.342 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.460581 | 0.337 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.460581 | 0.337 |
| R-HSA-75893 | TNF signaling | 0.460581 | 0.337 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.460581 | 0.337 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.465768 | 0.332 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.470907 | 0.327 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.470907 | 0.327 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.475996 | 0.322 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.475996 | 0.322 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.481037 | 0.318 |
| R-HSA-983189 | Kinesins | 0.481037 | 0.318 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.481037 | 0.318 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.481037 | 0.318 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.481610 | 0.317 |
| R-HSA-211976 | Endogenous sterols | 0.486029 | 0.313 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.490883 | 0.309 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.490974 | 0.309 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.490974 | 0.309 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.490974 | 0.309 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.490974 | 0.309 |
| R-HSA-186797 | Signaling by PDGF | 0.490974 | 0.309 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.493951 | 0.306 |
| R-HSA-5688426 | Deubiquitination | 0.494693 | 0.306 |
| R-HSA-373755 | Semaphorin interactions | 0.495872 | 0.305 |
| R-HSA-211981 | Xenobiotics | 0.500722 | 0.300 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.500722 | 0.300 |
| R-HSA-162587 | HIV Life Cycle | 0.503084 | 0.298 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.504772 | 0.297 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.510285 | 0.292 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.512112 | 0.291 |
| R-HSA-109582 | Hemostasis | 0.514184 | 0.289 |
| R-HSA-196807 | Nicotinate metabolism | 0.514998 | 0.288 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.519665 | 0.284 |
| R-HSA-167172 | Transcription of the HIV genome | 0.519665 | 0.284 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.519665 | 0.284 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.523982 | 0.281 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.528868 | 0.277 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.528868 | 0.277 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.528868 | 0.277 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.528868 | 0.277 |
| R-HSA-1266738 | Developmental Biology | 0.530988 | 0.275 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.533403 | 0.273 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.533403 | 0.273 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.533403 | 0.273 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.533403 | 0.273 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.533403 | 0.273 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.533403 | 0.273 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.537894 | 0.269 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.542343 | 0.266 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.546750 | 0.262 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.546750 | 0.262 |
| R-HSA-446728 | Cell junction organization | 0.548588 | 0.261 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.550855 | 0.259 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.551114 | 0.259 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.551114 | 0.259 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.555436 | 0.255 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.558419 | 0.253 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.558419 | 0.253 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.559717 | 0.252 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.563957 | 0.249 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.572316 | 0.242 |
| R-HSA-9833482 | PKR-mediated signaling | 0.572316 | 0.242 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.572316 | 0.242 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.576435 | 0.239 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.576435 | 0.239 |
| R-HSA-3781865 | Diseases of glycosylation | 0.583071 | 0.234 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.592523 | 0.227 |
| R-HSA-1500620 | Meiosis | 0.592523 | 0.227 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.600337 | 0.222 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.600337 | 0.222 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.600337 | 0.222 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.606704 | 0.217 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.609267 | 0.215 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.619228 | 0.208 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.626534 | 0.203 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.626534 | 0.203 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.630134 | 0.201 |
| R-HSA-1474290 | Collagen formation | 0.633700 | 0.198 |
| R-HSA-72172 | mRNA Splicing | 0.636626 | 0.196 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.637232 | 0.196 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.637815 | 0.195 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.644194 | 0.191 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.644194 | 0.191 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.647625 | 0.189 |
| R-HSA-388396 | GPCR downstream signalling | 0.647904 | 0.188 |
| R-HSA-3214847 | HATs acetylate histones | 0.654389 | 0.184 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.657885 | 0.182 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.664294 | 0.178 |
| R-HSA-418990 | Adherens junctions interactions | 0.669263 | 0.174 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.670740 | 0.173 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.680179 | 0.167 |
| R-HSA-69239 | Synthesis of DNA | 0.683266 | 0.165 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.686322 | 0.163 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.686322 | 0.163 |
| R-HSA-162906 | HIV Infection | 0.688976 | 0.162 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.689350 | 0.162 |
| R-HSA-6803157 | Antimicrobial peptides | 0.695318 | 0.158 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.698259 | 0.156 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.698259 | 0.156 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.698259 | 0.156 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.701172 | 0.154 |
| R-HSA-8939211 | ESR-mediated signaling | 0.709744 | 0.149 |
| R-HSA-157118 | Signaling by NOTCH | 0.715747 | 0.145 |
| R-HSA-68875 | Mitotic Prophase | 0.726162 | 0.139 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.734022 | 0.134 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.734022 | 0.134 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.736591 | 0.133 |
| R-HSA-421270 | Cell-cell junction organization | 0.736874 | 0.133 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.741657 | 0.130 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.741657 | 0.130 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.741657 | 0.130 |
| R-HSA-372790 | Signaling by GPCR | 0.746014 | 0.127 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.749075 | 0.125 |
| R-HSA-1474165 | Reproduction | 0.756281 | 0.121 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.760970 | 0.119 |
| R-HSA-5173105 | O-linked glycosylation | 0.774507 | 0.111 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.776774 | 0.110 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.778848 | 0.109 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.787282 | 0.104 |
| R-HSA-2262752 | Cellular responses to stress | 0.788850 | 0.103 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.789340 | 0.103 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.789369 | 0.103 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.797377 | 0.098 |
| R-HSA-2187338 | Visual phototransduction | 0.797377 | 0.098 |
| R-HSA-166520 | Signaling by NTRKs | 0.799338 | 0.097 |
| R-HSA-9758941 | Gastrulation | 0.801280 | 0.096 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.803203 | 0.095 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.806995 | 0.093 |
| R-HSA-9679506 | SARS-CoV Infections | 0.808396 | 0.092 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.808511 | 0.092 |
| R-HSA-69306 | DNA Replication | 0.808864 | 0.092 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.810714 | 0.091 |
| R-HSA-109581 | Apoptosis | 0.824892 | 0.084 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.833212 | 0.079 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.842679 | 0.074 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.844204 | 0.074 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.844204 | 0.074 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.844204 | 0.074 |
| R-HSA-1474244 | Extracellular matrix organization | 0.853709 | 0.069 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.872481 | 0.059 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.875498 | 0.058 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.879946 | 0.056 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.880263 | 0.055 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.880263 | 0.055 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.882577 | 0.054 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.886413 | 0.052 |
| R-HSA-5357801 | Programmed Cell Death | 0.887074 | 0.052 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.902815 | 0.044 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.908282 | 0.042 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.910676 | 0.041 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.911545 | 0.040 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.912959 | 0.040 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.917398 | 0.037 |
| R-HSA-9824446 | Viral Infection Pathways | 0.930709 | 0.031 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.931415 | 0.031 |
| R-HSA-5668914 | Diseases of metabolism | 0.931463 | 0.031 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.935960 | 0.029 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.944717 | 0.025 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.945341 | 0.024 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.946320 | 0.024 |
| R-HSA-9658195 | Leishmania infection | 0.946320 | 0.024 |
| R-HSA-199991 | Membrane Trafficking | 0.958044 | 0.019 |
| R-HSA-1280218 | Adaptive Immune System | 0.978741 | 0.009 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.985461 | 0.006 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.986751 | 0.006 |
| R-HSA-449147 | Signaling by Interleukins | 0.986889 | 0.006 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.987664 | 0.005 |
| R-HSA-168256 | Immune System | 0.989678 | 0.005 |
| R-HSA-6798695 | Neutrophil degranulation | 0.990634 | 0.004 |
| R-HSA-9709957 | Sensory Perception | 0.994437 | 0.002 |
| R-HSA-5663205 | Infectious disease | 0.994645 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.995140 | 0.002 |
| R-HSA-1643685 | Disease | 0.996254 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.997188 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998119 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 0.999793 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999966 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.859 | 0.858 | 1 | 0.776 |
KIS |
0.842 | 0.770 | 1 | 0.712 |
DYRK4 |
0.841 | 0.834 | 1 | 0.785 |
CDK19 |
0.841 | 0.816 | 1 | 0.779 |
DYRK2 |
0.841 | 0.840 | 1 | 0.679 |
P38G |
0.837 | 0.844 | 1 | 0.841 |
CDK18 |
0.835 | 0.815 | 1 | 0.796 |
CDK17 |
0.834 | 0.825 | 1 | 0.832 |
CDK7 |
0.833 | 0.809 | 1 | 0.742 |
CDK8 |
0.833 | 0.808 | 1 | 0.739 |
HIPK4 |
0.831 | 0.659 | 1 | 0.449 |
P38D |
0.831 | 0.835 | 1 | 0.838 |
DYRK1B |
0.830 | 0.804 | 1 | 0.737 |
JNK2 |
0.830 | 0.842 | 1 | 0.792 |
HIPK1 |
0.830 | 0.792 | 1 | 0.657 |
DYRK1A |
0.827 | 0.750 | 1 | 0.636 |
P38B |
0.827 | 0.822 | 1 | 0.758 |
CDK3 |
0.826 | 0.706 | 1 | 0.823 |
ERK1 |
0.826 | 0.805 | 1 | 0.775 |
CDK12 |
0.824 | 0.801 | 1 | 0.790 |
CDK13 |
0.824 | 0.793 | 1 | 0.766 |
CDK16 |
0.822 | 0.779 | 1 | 0.817 |
CDK1 |
0.822 | 0.771 | 1 | 0.772 |
CDK9 |
0.821 | 0.795 | 1 | 0.758 |
SRPK1 |
0.820 | 0.505 | -3 | 0.906 |
JNK3 |
0.820 | 0.825 | 1 | 0.761 |
CDK10 |
0.820 | 0.764 | 1 | 0.768 |
HIPK3 |
0.820 | 0.776 | 1 | 0.628 |
CLK3 |
0.818 | 0.563 | 1 | 0.416 |
CDK14 |
0.817 | 0.800 | 1 | 0.750 |
CDK5 |
0.816 | 0.752 | 1 | 0.711 |
P38A |
0.815 | 0.796 | 1 | 0.679 |
CLK2 |
0.815 | 0.542 | -3 | 0.909 |
DYRK3 |
0.813 | 0.661 | 1 | 0.619 |
SRPK2 |
0.811 | 0.442 | -3 | 0.878 |
CDK4 |
0.809 | 0.785 | 1 | 0.799 |
CLK1 |
0.807 | 0.542 | -3 | 0.910 |
ERK2 |
0.805 | 0.782 | 1 | 0.719 |
MAK |
0.805 | 0.625 | -2 | 0.818 |
CLK4 |
0.804 | 0.514 | -3 | 0.913 |
JNK1 |
0.802 | 0.742 | 1 | 0.794 |
CDK6 |
0.801 | 0.738 | 1 | 0.771 |
NLK |
0.798 | 0.713 | 1 | 0.452 |
CDKL5 |
0.797 | 0.346 | -3 | 0.917 |
ICK |
0.795 | 0.517 | -3 | 0.912 |
SRPK3 |
0.794 | 0.390 | -3 | 0.880 |
MOK |
0.794 | 0.593 | 1 | 0.541 |
CDK2 |
0.789 | 0.579 | 1 | 0.637 |
CDKL1 |
0.788 | 0.340 | -3 | 0.912 |
ERK5 |
0.788 | 0.396 | 1 | 0.367 |
NDR2 |
0.782 | 0.133 | -3 | 0.871 |
MTOR |
0.781 | 0.234 | 1 | 0.242 |
PRKD1 |
0.780 | 0.177 | -3 | 0.900 |
PRKD2 |
0.777 | 0.186 | -3 | 0.905 |
PIM3 |
0.777 | 0.128 | -3 | 0.900 |
RSK2 |
0.774 | 0.166 | -3 | 0.918 |
PRP4 |
0.774 | 0.463 | -3 | 0.698 |
P90RSK |
0.772 | 0.178 | -3 | 0.920 |
NDR1 |
0.771 | 0.088 | -3 | 0.900 |
PIM1 |
0.770 | 0.180 | -3 | 0.906 |
NUAK2 |
0.769 | 0.149 | -3 | 0.910 |
MAPKAPK2 |
0.769 | 0.147 | -3 | 0.895 |
CDC7 |
0.769 | -0.044 | 1 | 0.068 |
RSK3 |
0.768 | 0.147 | -3 | 0.920 |
PKN3 |
0.768 | 0.088 | -3 | 0.900 |
COT |
0.768 | -0.089 | 2 | 0.799 |
CAMK1B |
0.768 | 0.126 | -3 | 0.909 |
MOS |
0.767 | 0.020 | 1 | 0.107 |
TBK1 |
0.767 | -0.103 | 1 | 0.037 |
MAPKAPK3 |
0.767 | 0.121 | -3 | 0.908 |
MARK4 |
0.766 | 0.064 | 4 | 0.856 |
IKKE |
0.764 | -0.110 | 1 | 0.037 |
LATS2 |
0.764 | 0.070 | -5 | 0.756 |
PRKD3 |
0.764 | 0.164 | -3 | 0.906 |
SKMLCK |
0.763 | 0.070 | -2 | 0.865 |
AMPKA2 |
0.763 | 0.109 | -3 | 0.902 |
AMPKA1 |
0.763 | 0.077 | -3 | 0.899 |
ATR |
0.763 | -0.002 | 1 | 0.104 |
P70S6KB |
0.763 | 0.131 | -3 | 0.917 |
PKACB |
0.762 | 0.140 | -2 | 0.669 |
PRPK |
0.762 | -0.047 | -1 | 0.830 |
PKACG |
0.761 | 0.080 | -2 | 0.748 |
QSK |
0.760 | 0.115 | 4 | 0.840 |
RAF1 |
0.760 | -0.116 | 1 | 0.049 |
AURC |
0.760 | 0.074 | -2 | 0.656 |
AKT2 |
0.760 | 0.188 | -3 | 0.888 |
CAMLCK |
0.760 | 0.102 | -2 | 0.839 |
MST4 |
0.759 | -0.008 | 2 | 0.792 |
ERK7 |
0.759 | 0.258 | 2 | 0.511 |
NIM1 |
0.759 | 0.043 | 3 | 0.780 |
SIK |
0.759 | 0.128 | -3 | 0.885 |
WNK1 |
0.759 | -0.018 | -2 | 0.888 |
IKKB |
0.759 | -0.114 | -2 | 0.750 |
PDHK4 |
0.759 | -0.101 | 1 | 0.115 |
RSK4 |
0.758 | 0.151 | -3 | 0.890 |
MSK2 |
0.758 | 0.124 | -3 | 0.896 |
PKCD |
0.758 | 0.050 | 2 | 0.708 |
PRKX |
0.758 | 0.160 | -3 | 0.854 |
GCN2 |
0.757 | -0.156 | 2 | 0.727 |
PKN2 |
0.757 | 0.026 | -3 | 0.893 |
NUAK1 |
0.757 | 0.107 | -3 | 0.910 |
SGK3 |
0.757 | 0.134 | -3 | 0.908 |
TSSK1 |
0.756 | 0.064 | -3 | 0.900 |
NIK |
0.756 | 0.048 | -3 | 0.874 |
PIM2 |
0.756 | 0.173 | -3 | 0.911 |
CAMK2D |
0.756 | 0.030 | -3 | 0.888 |
DAPK2 |
0.756 | 0.093 | -3 | 0.896 |
LATS1 |
0.756 | 0.128 | -3 | 0.871 |
MSK1 |
0.755 | 0.122 | -3 | 0.906 |
PDHK1 |
0.755 | -0.124 | 1 | 0.094 |
BRSK1 |
0.753 | 0.086 | -3 | 0.907 |
MELK |
0.753 | 0.065 | -3 | 0.907 |
PHKG1 |
0.753 | 0.038 | -3 | 0.893 |
CHAK2 |
0.753 | -0.041 | -1 | 0.816 |
DNAPK |
0.753 | -0.002 | 1 | 0.107 |
BMPR2 |
0.751 | -0.158 | -2 | 0.858 |
PAK1 |
0.751 | 0.034 | -2 | 0.783 |
MAPKAPK5 |
0.751 | 0.101 | -3 | 0.895 |
BCKDK |
0.751 | -0.108 | -1 | 0.785 |
MARK3 |
0.751 | 0.076 | 4 | 0.818 |
PAK6 |
0.750 | 0.047 | -2 | 0.695 |
PKCB |
0.750 | 0.040 | 2 | 0.668 |
HUNK |
0.750 | -0.103 | 2 | 0.737 |
CAMK2G |
0.750 | -0.086 | 2 | 0.751 |
DSTYK |
0.750 | -0.158 | 2 | 0.831 |
PKACA |
0.749 | 0.132 | -2 | 0.621 |
BRSK2 |
0.749 | 0.037 | -3 | 0.898 |
ULK2 |
0.749 | -0.197 | 2 | 0.706 |
PAK3 |
0.749 | 0.007 | -2 | 0.778 |
SBK |
0.748 | 0.302 | -3 | 0.833 |
ATM |
0.748 | -0.046 | 1 | 0.077 |
CAMK2A |
0.748 | 0.079 | 2 | 0.744 |
PKG2 |
0.748 | 0.074 | -2 | 0.679 |
NEK6 |
0.748 | -0.110 | -2 | 0.824 |
IKKA |
0.748 | -0.073 | -2 | 0.746 |
QIK |
0.748 | 0.020 | -3 | 0.871 |
MNK2 |
0.748 | 0.011 | -2 | 0.790 |
MARK2 |
0.747 | 0.063 | 4 | 0.789 |
TSSK2 |
0.747 | -0.003 | -5 | 0.805 |
WNK3 |
0.747 | -0.148 | 1 | 0.049 |
MNK1 |
0.747 | 0.039 | -2 | 0.802 |
MASTL |
0.747 | -0.090 | -2 | 0.828 |
CAMK2B |
0.747 | 0.038 | 2 | 0.743 |
AKT1 |
0.747 | 0.141 | -3 | 0.893 |
FAM20C |
0.747 | 0.045 | 2 | 0.682 |
GRK1 |
0.746 | -0.035 | -2 | 0.819 |
PKCA |
0.746 | 0.025 | 2 | 0.659 |
TGFBR2 |
0.745 | -0.092 | -2 | 0.733 |
CAMK4 |
0.745 | -0.007 | -3 | 0.886 |
RIPK3 |
0.745 | -0.146 | 3 | 0.705 |
PKCG |
0.745 | 0.013 | 2 | 0.664 |
GRK5 |
0.745 | -0.138 | -3 | 0.740 |
AURB |
0.745 | 0.036 | -2 | 0.649 |
DCAMKL1 |
0.744 | 0.098 | -3 | 0.901 |
PKCZ |
0.744 | 0.006 | 2 | 0.709 |
MLK2 |
0.744 | -0.098 | 2 | 0.754 |
IRE1 |
0.743 | -0.091 | 1 | 0.048 |
SGK1 |
0.743 | 0.201 | -3 | 0.853 |
MYLK4 |
0.743 | 0.068 | -2 | 0.759 |
CAMK1G |
0.742 | 0.082 | -3 | 0.904 |
MPSK1 |
0.742 | 0.078 | 1 | 0.123 |
P70S6K |
0.742 | 0.117 | -3 | 0.897 |
NEK7 |
0.741 | -0.207 | -3 | 0.742 |
BMPR1B |
0.741 | -0.051 | 1 | 0.042 |
AKT3 |
0.741 | 0.168 | -3 | 0.858 |
MARK1 |
0.741 | 0.041 | 4 | 0.828 |
CHK1 |
0.741 | 0.043 | -3 | 0.884 |
RIPK1 |
0.741 | -0.143 | 1 | 0.038 |
MLK1 |
0.740 | -0.178 | 2 | 0.744 |
PINK1 |
0.740 | 0.145 | 1 | 0.269 |
PKCH |
0.740 | 0.003 | 2 | 0.650 |
GRK7 |
0.739 | -0.010 | 1 | 0.086 |
PAK2 |
0.739 | -0.007 | -2 | 0.766 |
NEK9 |
0.739 | -0.177 | 2 | 0.763 |
GSK3A |
0.738 | 0.183 | 4 | 0.430 |
ULK1 |
0.738 | -0.194 | -3 | 0.728 |
PHKG2 |
0.738 | 0.016 | -3 | 0.893 |
IRE2 |
0.738 | -0.087 | 2 | 0.673 |
PAK5 |
0.738 | 0.031 | -2 | 0.649 |
GRK6 |
0.737 | -0.133 | 1 | 0.048 |
DLK |
0.737 | -0.168 | 1 | 0.062 |
PKN1 |
0.737 | 0.099 | -3 | 0.904 |
VRK2 |
0.737 | 0.044 | 1 | 0.151 |
CAMK1D |
0.737 | 0.125 | -3 | 0.883 |
SMG1 |
0.737 | -0.068 | 1 | 0.094 |
MLK3 |
0.736 | -0.087 | 2 | 0.677 |
AURA |
0.736 | 0.020 | -2 | 0.614 |
PKCT |
0.736 | 0.023 | 2 | 0.656 |
TGFBR1 |
0.735 | -0.063 | -2 | 0.749 |
SNRK |
0.735 | -0.055 | 2 | 0.603 |
SSTK |
0.735 | 0.037 | 4 | 0.827 |
YSK4 |
0.735 | -0.132 | 1 | 0.039 |
PKR |
0.735 | -0.079 | 1 | 0.066 |
ANKRD3 |
0.735 | -0.177 | 1 | 0.063 |
PAK4 |
0.734 | 0.035 | -2 | 0.650 |
ALK4 |
0.734 | -0.080 | -2 | 0.782 |
PASK |
0.734 | 0.078 | -3 | 0.873 |
GRK4 |
0.733 | -0.163 | -2 | 0.813 |
DCAMKL2 |
0.733 | 0.044 | -3 | 0.910 |
NEK2 |
0.732 | -0.129 | 2 | 0.748 |
TTBK2 |
0.732 | -0.189 | 2 | 0.633 |
WNK4 |
0.731 | -0.059 | -2 | 0.881 |
MEK1 |
0.731 | -0.118 | 2 | 0.769 |
MRCKB |
0.730 | 0.122 | -3 | 0.898 |
PKCE |
0.730 | 0.070 | 2 | 0.656 |
PKCI |
0.730 | 0.019 | 2 | 0.676 |
CHAK1 |
0.729 | -0.142 | 2 | 0.715 |
SMMLCK |
0.729 | 0.071 | -3 | 0.910 |
CHK2 |
0.729 | 0.143 | -3 | 0.868 |
ROCK2 |
0.729 | 0.121 | -3 | 0.905 |
PDK1 |
0.728 | 0.038 | 1 | 0.091 |
DRAK1 |
0.728 | -0.111 | 1 | 0.032 |
MST3 |
0.727 | -0.042 | 2 | 0.775 |
TAO3 |
0.727 | -0.020 | 1 | 0.084 |
TLK2 |
0.727 | -0.126 | 1 | 0.042 |
ALK2 |
0.727 | -0.084 | -2 | 0.757 |
CAMK1A |
0.727 | 0.127 | -3 | 0.868 |
MRCKA |
0.726 | 0.105 | -3 | 0.902 |
PLK1 |
0.725 | -0.165 | -2 | 0.760 |
DAPK3 |
0.725 | 0.079 | -3 | 0.905 |
MEKK1 |
0.724 | -0.144 | 1 | 0.060 |
MEK5 |
0.723 | -0.142 | 2 | 0.749 |
ACVR2B |
0.722 | -0.125 | -2 | 0.740 |
PLK4 |
0.722 | -0.143 | 2 | 0.555 |
ACVR2A |
0.722 | -0.127 | -2 | 0.723 |
PLK3 |
0.722 | -0.137 | 2 | 0.701 |
GRK2 |
0.722 | -0.091 | -2 | 0.703 |
MLK4 |
0.722 | -0.154 | 2 | 0.652 |
CRIK |
0.722 | 0.161 | -3 | 0.892 |
IRAK4 |
0.721 | -0.131 | 1 | 0.029 |
BMPR1A |
0.721 | -0.081 | 1 | 0.035 |
PKG1 |
0.721 | 0.076 | -2 | 0.597 |
PBK |
0.720 | 0.020 | 1 | 0.095 |
GSK3B |
0.720 | 0.040 | 4 | 0.420 |
DMPK1 |
0.720 | 0.141 | -3 | 0.900 |
PERK |
0.719 | -0.158 | -2 | 0.787 |
TAO2 |
0.719 | -0.043 | 2 | 0.775 |
BRAF |
0.719 | -0.130 | -4 | 0.785 |
MEKK2 |
0.718 | -0.144 | 2 | 0.730 |
NEK5 |
0.718 | -0.159 | 1 | 0.044 |
ZAK |
0.718 | -0.177 | 1 | 0.047 |
DAPK1 |
0.718 | 0.071 | -3 | 0.900 |
HRI |
0.718 | -0.183 | -2 | 0.799 |
BUB1 |
0.718 | 0.058 | -5 | 0.710 |
GAK |
0.717 | -0.030 | 1 | 0.106 |
LOK |
0.717 | -0.020 | -2 | 0.790 |
KHS1 |
0.717 | -0.003 | 1 | 0.058 |
GCK |
0.717 | -0.050 | 1 | 0.063 |
ROCK1 |
0.717 | 0.107 | -3 | 0.903 |
LKB1 |
0.716 | -0.046 | -3 | 0.768 |
TLK1 |
0.716 | -0.152 | -2 | 0.785 |
HPK1 |
0.716 | -0.036 | 1 | 0.065 |
MAP3K15 |
0.716 | -0.073 | 1 | 0.062 |
MEKK6 |
0.716 | -0.068 | 1 | 0.060 |
CK1E |
0.715 | -0.061 | -3 | 0.397 |
MEKK3 |
0.715 | -0.203 | 1 | 0.057 |
NEK11 |
0.714 | -0.135 | 1 | 0.077 |
TNIK |
0.714 | -0.036 | 3 | 0.836 |
HGK |
0.714 | -0.065 | 3 | 0.832 |
KHS2 |
0.713 | -0.002 | 1 | 0.069 |
SLK |
0.712 | -0.030 | -2 | 0.750 |
CK2A2 |
0.712 | -0.075 | 1 | 0.038 |
HASPIN |
0.711 | 0.023 | -1 | 0.657 |
NEK4 |
0.711 | -0.145 | 1 | 0.035 |
LRRK2 |
0.711 | 0.005 | 2 | 0.775 |
NEK8 |
0.710 | -0.162 | 2 | 0.742 |
MINK |
0.709 | -0.110 | 1 | 0.038 |
CAMKK2 |
0.708 | -0.124 | -2 | 0.766 |
CK1D |
0.708 | -0.039 | -3 | 0.344 |
TTBK1 |
0.706 | -0.180 | 2 | 0.550 |
CK1G1 |
0.706 | -0.096 | -3 | 0.392 |
IRAK1 |
0.706 | -0.204 | -1 | 0.715 |
GRK3 |
0.705 | -0.099 | -2 | 0.659 |
NEK1 |
0.705 | -0.144 | 1 | 0.029 |
CAMKK1 |
0.705 | -0.197 | -2 | 0.762 |
MST2 |
0.704 | -0.153 | 1 | 0.046 |
YSK1 |
0.704 | -0.098 | 2 | 0.740 |
VRK1 |
0.702 | -0.154 | 2 | 0.761 |
CK2A1 |
0.702 | -0.086 | 1 | 0.032 |
NEK3 |
0.700 | -0.102 | 1 | 0.063 |
CK1A2 |
0.700 | -0.069 | -3 | 0.356 |
RIPK2 |
0.699 | -0.184 | 1 | 0.034 |
TAK1 |
0.699 | -0.177 | 1 | 0.038 |
LIMK2_TYR |
0.699 | 0.186 | -3 | 0.847 |
MST1 |
0.698 | -0.152 | 1 | 0.037 |
PDHK3_TYR |
0.698 | 0.158 | 4 | 0.864 |
EEF2K |
0.697 | -0.131 | 3 | 0.762 |
TAO1 |
0.696 | -0.058 | 1 | 0.059 |
MEK2 |
0.696 | -0.183 | 2 | 0.738 |
BIKE |
0.696 | -0.035 | 1 | 0.110 |
STK33 |
0.696 | -0.136 | 2 | 0.539 |
AAK1 |
0.695 | 0.005 | 1 | 0.128 |
PKMYT1_TYR |
0.695 | 0.184 | 3 | 0.846 |
TESK1_TYR |
0.693 | 0.083 | 3 | 0.863 |
PLK2 |
0.692 | -0.104 | -3 | 0.686 |
MAP2K4_TYR |
0.691 | 0.093 | -1 | 0.851 |
ASK1 |
0.691 | -0.110 | 1 | 0.063 |
MYO3B |
0.690 | -0.072 | 2 | 0.762 |
OSR1 |
0.689 | -0.098 | 2 | 0.725 |
MAP2K6_TYR |
0.687 | 0.053 | -1 | 0.851 |
PDHK4_TYR |
0.687 | 0.035 | 2 | 0.807 |
MAP2K7_TYR |
0.686 | -0.027 | 2 | 0.788 |
RET |
0.684 | -0.071 | 1 | 0.076 |
PINK1_TYR |
0.684 | -0.064 | 1 | 0.106 |
MYO3A |
0.684 | -0.104 | 1 | 0.056 |
LIMK1_TYR |
0.684 | 0.041 | 2 | 0.782 |
BMPR2_TYR |
0.681 | -0.008 | -1 | 0.823 |
PDHK1_TYR |
0.680 | -0.048 | -1 | 0.859 |
NEK10_TYR |
0.680 | -0.050 | 1 | 0.068 |
JAK2 |
0.680 | -0.085 | 1 | 0.086 |
MST1R |
0.680 | -0.066 | 3 | 0.820 |
TTK |
0.680 | -0.131 | -2 | 0.768 |
DDR1 |
0.677 | -0.062 | 4 | 0.798 |
CSF1R |
0.676 | -0.078 | 3 | 0.800 |
TNK1 |
0.676 | -0.017 | 3 | 0.807 |
ROS1 |
0.676 | -0.108 | 3 | 0.779 |
ALPHAK3 |
0.676 | -0.114 | -1 | 0.730 |
TYK2 |
0.675 | -0.179 | 1 | 0.063 |
ABL2 |
0.675 | -0.055 | -1 | 0.765 |
EPHA6 |
0.674 | -0.085 | -1 | 0.804 |
YANK3 |
0.674 | -0.068 | 2 | 0.348 |
TNNI3K_TYR |
0.673 | -0.032 | 1 | 0.091 |
JAK3 |
0.673 | -0.112 | 1 | 0.071 |
EPHB4 |
0.673 | -0.101 | -1 | 0.787 |
FGFR2 |
0.672 | -0.035 | 3 | 0.770 |
TYRO3 |
0.672 | -0.150 | 3 | 0.813 |
JAK1 |
0.671 | -0.087 | 1 | 0.061 |
FGFR1 |
0.671 | -0.029 | 3 | 0.764 |
ABL1 |
0.671 | -0.060 | -1 | 0.763 |
DDR2 |
0.670 | 0.021 | 3 | 0.714 |
YES1 |
0.670 | -0.095 | -1 | 0.824 |
STLK3 |
0.670 | -0.188 | 1 | 0.034 |
FGR |
0.669 | -0.132 | 1 | 0.038 |
TNK2 |
0.668 | -0.089 | 3 | 0.762 |
CK1A |
0.667 | -0.080 | -3 | 0.253 |
INSRR |
0.667 | -0.117 | 3 | 0.748 |
TXK |
0.667 | -0.099 | 1 | 0.036 |
TEK |
0.667 | -0.026 | 3 | 0.746 |
KDR |
0.666 | -0.087 | 3 | 0.749 |
FLT3 |
0.665 | -0.144 | 3 | 0.812 |
PDGFRB |
0.664 | -0.174 | 3 | 0.802 |
LCK |
0.664 | -0.108 | -1 | 0.782 |
KIT |
0.663 | -0.126 | 3 | 0.794 |
EPHA4 |
0.662 | -0.091 | 2 | 0.709 |
FER |
0.662 | -0.182 | 1 | 0.051 |
BLK |
0.662 | -0.099 | -1 | 0.786 |
HCK |
0.661 | -0.153 | -1 | 0.780 |
FGFR3 |
0.661 | -0.061 | 3 | 0.745 |
MET |
0.660 | -0.104 | 3 | 0.806 |
ITK |
0.660 | -0.152 | -1 | 0.746 |
PDGFRA |
0.659 | -0.181 | 3 | 0.799 |
EPHB3 |
0.658 | -0.156 | -1 | 0.767 |
EPHB2 |
0.658 | -0.143 | -1 | 0.764 |
EPHB1 |
0.658 | -0.183 | 1 | 0.033 |
AXL |
0.657 | -0.161 | 3 | 0.774 |
SRMS |
0.657 | -0.181 | 1 | 0.027 |
MERTK |
0.657 | -0.149 | 3 | 0.789 |
ALK |
0.656 | -0.145 | 3 | 0.733 |
FYN |
0.654 | -0.101 | -1 | 0.765 |
PTK2B |
0.653 | -0.079 | -1 | 0.737 |
FLT1 |
0.653 | -0.134 | -1 | 0.788 |
LTK |
0.653 | -0.154 | 3 | 0.745 |
INSR |
0.652 | -0.145 | 3 | 0.741 |
EPHA1 |
0.652 | -0.140 | 3 | 0.779 |
ERBB2 |
0.652 | -0.166 | 1 | 0.051 |
NTRK1 |
0.652 | -0.196 | -1 | 0.785 |
WEE1_TYR |
0.651 | -0.111 | -1 | 0.703 |
BMX |
0.651 | -0.137 | -1 | 0.655 |
BTK |
0.651 | -0.214 | -1 | 0.717 |
FLT4 |
0.651 | -0.152 | 3 | 0.731 |
EPHA7 |
0.650 | -0.142 | 2 | 0.706 |
EGFR |
0.650 | -0.111 | 1 | 0.037 |
TEC |
0.650 | -0.167 | -1 | 0.687 |
FRK |
0.649 | -0.162 | -1 | 0.781 |
NTRK2 |
0.649 | -0.205 | 3 | 0.757 |
NTRK3 |
0.649 | -0.150 | -1 | 0.737 |
EPHA3 |
0.647 | -0.145 | 2 | 0.677 |
PTK6 |
0.646 | -0.203 | -1 | 0.693 |
SRC |
0.645 | -0.129 | -1 | 0.773 |
EPHA8 |
0.644 | -0.128 | -1 | 0.742 |
CSK |
0.644 | -0.135 | 2 | 0.702 |
FGFR4 |
0.644 | -0.108 | -1 | 0.729 |
MUSK |
0.643 | -0.134 | 1 | 0.020 |
LYN |
0.643 | -0.161 | 3 | 0.724 |
EPHA5 |
0.643 | -0.142 | 2 | 0.695 |
MATK |
0.643 | -0.113 | -1 | 0.696 |
PTK2 |
0.643 | -0.069 | -1 | 0.733 |
CK1G3 |
0.640 | -0.096 | -3 | 0.207 |
ERBB4 |
0.638 | -0.104 | 1 | 0.036 |
IGF1R |
0.637 | -0.141 | 3 | 0.689 |
SYK |
0.637 | -0.096 | -1 | 0.716 |
YANK2 |
0.635 | -0.103 | 2 | 0.364 |
EPHA2 |
0.634 | -0.135 | -1 | 0.706 |
ZAP70 |
0.634 | -0.052 | -1 | 0.636 |
CK1G2 |
0.621 | -0.095 | -3 | 0.304 |
FES |
0.618 | -0.162 | -1 | 0.648 |