Motif 471 (n=162)

Position-wise Probabilities

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uniprot genes site source protein function
H0Y626 None S36 ochoa RING-type E3 ubiquitin transferase (EC 2.3.2.27) None
O00267 SUPT5H S780 ochoa Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.
O00512 BCL9 S885 ochoa B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}.
O43294 TGFB1I1 S150 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O43566 RGS14 S52 ochoa Regulator of G-protein signaling 14 (RGS14) Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}.
O60293 ZFC3H1 S655 ochoa Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}.
O60336 MAPKBP1 S1261 ochoa Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.
O75674 TOM1L1 S321 ochoa TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}.
O75925 PIAS1 S510 ochoa|psp E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}.
O75995 SASH3 S153 ochoa SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}.
O94868 FCHSD2 S681 ochoa|psp F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.
O94868 FCHSD2 S693 ochoa F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.
O94885 SASH1 S335 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O95251 KAT7 S57 ochoa|psp Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}.
O95251 KAT7 S136 ochoa Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}.
O95359 TACC2 S2569 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O95359 TACC2 S2574 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O95361 TRIM16 S36 ochoa Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}.
P00519 ABL1 S683 ochoa Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
P01106 MYC S86 psp Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}.
P02671 FGA S297 ochoa Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P06400 RB1 S807 ochoa|psp Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}.
P10071 GLI3 S662 ochoa Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}.
P10071 GLI3 S664 ochoa Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}.
P10636 MAPT S733 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11137 MAP2 S1802 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P16144 ITGB4 S1518 ochoa Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P20700 LMNB1 S408 ochoa Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P21333 FLNA S966 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21359 NF1 S883 ochoa Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.
P22681 CBL S646 ochoa E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P29558 RBMS1 S50 ochoa RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.
P30622 CLIP1 S159 ochoa CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P35367 HRH1 S275 ochoa Histamine H1 receptor (H1-R) (H1R) (HH1R) G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}.
P37275 ZEB1 S583 ochoa Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}.
P52948 NUP98 S1043 ochoa Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
P54725 RAD23A S144 ochoa UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}.
P54727 RAD23B S172 ochoa UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.
P55265 ADAR S491 ochoa Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}.
P57078 RIPK4 S438 ochoa Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}.
P57682 KLF3 S78 ochoa|psp Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.
Q00587 CDC42EP1 S77 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q00613 HSF1 S326 ochoa|psp Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}.
Q01167 FOXK2 S385 ochoa Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}.
Q02880 TOP2B S1461 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q03164 KMT2A S3527 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q03252 LMNB2 S422 ochoa Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q04656 ATP7A S270 ochoa|psp Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}.
Q07157 TJP1 S411 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q08174 PCDH1 S1018 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q09666 AHNAK S5589 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12778 FOXO1 S329 ochoa|psp Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}.
Q12802 AKAP13 S1904 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12802 AKAP13 S2718 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12872 SFSWAP S893 ochoa Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}.
Q12965 MYO1E S1009 ochoa Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}.
Q13131 PRKAA1 S524 ochoa 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
Q13501 SQSTM1 S284 ochoa Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q13884 SNTB1 S231 ochoa Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Q14004 CDK13 S395 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14157 UBAP2L S859 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14699 RFTN1 S175 ochoa Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
Q15276 RABEP1 S414 ochoa Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.
Q15596 NCOA2 S675 ochoa Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}.
Q15678 PTPN14 S538 ochoa Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}.
Q4VCS5 AMOT S332 ochoa Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q4VCS5 AMOT S859 ochoa Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q53GG5 PDLIM3 S152 ochoa PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}.
Q53T59 HS1BP3 S151 ochoa HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) May be a modulator of IL-2 signaling. {ECO:0000250}.
Q58EX2 SDK2 S2026 ochoa Protein sidekick-2 Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}.
Q5HYJ3 FAM76B S231 ochoa Protein FAM76B Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448). {ECO:0000269|PubMed:37643469, ECO:0000269|PubMed:38421448}.
Q5T200 ZC3H13 S585 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5T4S7 UBR4 S2904 ochoa E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}.
Q5VT52 RPRD2 S491 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q5VZ89 DENND4C S1344 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q63HR2 TNS2 S1003 ochoa Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}.
Q66K74 MAP1S S655 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q69YQ0 SPECC1L S893 ochoa Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}.
Q6IA17 SIGIRR S380 ochoa Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8) Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876, ECO:0000269|PubMed:25963006}.
Q6L8Q7 PDE12 S224 ochoa 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}.
Q6P1R3 MSANTD2 S39 ochoa Myb/SANT-like DNA-binding domain-containing protein 2 None
Q6P2E9 EDC4 S741 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6PJI9 WDR59 S834 ochoa GATOR2 complex protein WDR59 (WD repeat-containing protein 59) As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36577058}.
Q6PKG0 LARP1 S868 ochoa La-related protein 1 (La ribonucleoprotein domain family member 1) RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
Q6VY07 PACS1 S493 ochoa Phosphofurin acidic cluster sorting protein 1 (PACS-1) Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}.
Q6WCQ1 MPRIP S301 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6WKZ4 RAB11FIP1 S241 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZSR9 None S294 ochoa Uncharacterized protein FLJ45252 None
Q6ZUT6 CCDC9B S407 ochoa Coiled-coil domain-containing protein 9B None
Q7KZI7 MARK2 S631 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q7L1W4 LRRC8D S246 ochoa Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). {ECO:0000250|UniProtKB:Q8BGR2, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:32415200, ECO:0000269|PubMed:33171122}.
Q7Z6E9 RBBP6 S1277 ochoa E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}.
Q86U70 LDB1 S309 ochoa LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}.
Q86UU0 BCL9L S954 ochoa B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86XK3 SFR1 S48 ochoa Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}.
Q86XL3 ANKLE2 S268 ochoa Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.
Q86YW5 TREML1 S217 ochoa Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}.
Q8IZH2 XRN1 S1657 ochoa 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}.
Q8N3F8 MICALL1 S562 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8N3V7 SYNPO S882 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N6T3 ARFGAP1 S355 ochoa ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}.
Q8NEF9 SRFBP1 S215 ochoa Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.
Q8NEY1 NAV1 S312 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NEY1 NAV1 S652 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NFH5 NUP35 S259 ochoa Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.
Q8NHV4 NEDD1 S460 ochoa|psp Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8NI27 THOC2 S1219 ochoa THO complex subunit 2 (Tho2) (hTREX120) Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}.
Q8TD19 NEK9 S836 ochoa Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.
Q8TEW8 PARD3B S364 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WXG6 MADD S707 ochoa MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}.
Q92539 LPIN2 S132 ochoa Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}.
Q92560 BAP1 S583 ochoa|psp Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}.
Q92613 JADE3 S707 ochoa Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}.
Q92945 KHSRP S132 ochoa|psp Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.
Q96AP7 ESAM S371 ochoa Endothelial cell-selective adhesion molecule Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}.
Q96B97 SH3KBP1 S86 ochoa SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.
Q96JK2 DCAF5 S655 ochoa DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.
Q96JY6 PDLIM2 S141 ochoa PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.
Q96RL1 UIMC1 S204 ochoa BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}.
Q96RT1 ERBIN S1140 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96S59 RANBP9 S489 ochoa Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.
Q96T58 SPEN S2493 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99618 CDCA3 S172 ochoa Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.
Q99700 ATXN2 S861 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q9BSQ5 CCM2 S287 ochoa Cerebral cavernous malformations 2 protein (Malcavernin) Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BTA9 WAC S523 ochoa WW domain-containing adapter protein with coiled-coil Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}.
Q9BTA9 WAC S532 ochoa WW domain-containing adapter protein with coiled-coil Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}.
Q9BX66 SORBS1 S479 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9BXF6 RAB11FIP5 S365 ochoa Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}.
Q9C0C2 TNKS1BP1 S287 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C2 TNKS1BP1 S724 ochoa 182 kDa tankyrase-1-binding protein None
Q9H1K0 RBSN S590 ochoa Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.
Q9H2G2 SLK S348 ochoa|psp STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.
Q9H2S9 IKZF4 S89 ochoa Zinc finger protein Eos (Ikaros family zinc finger protein 4) DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}.
Q9H4Z3 PCIF1 S144 ochoa mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}.
Q9H6K1 ILRUN S272 ochoa Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}.
Q9H6U6 BCAS3 S161 ochoa BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}.
Q9HCD6 TANC2 S144 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9NQ84 GPRC5C S368 ochoa G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}.
Q9NTZ6 RBM12 S420 ochoa RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) None
Q9NX95 SYBU S54 ochoa Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}.
Q9NZ72 STMN3 S72 ochoa Stathmin-3 (SCG10-like protein) Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}.
Q9P0K7 RAI14 S293 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9P0K7 RAI14 S412 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9P1Y5 CAMSAP3 S380 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9UBW5 BIN2 S292 ochoa Bridging integrator 2 (Breast cancer-associated protein 1) Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Q9UHB6 LIMA1 S369 ochoa LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9ULU4 ZMYND8 S40 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9UN79 SOX13 S386 ochoa Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}.
Q9UPQ0 LIMCH1 S973 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9Y2H0 DLGAP4 S615 ochoa Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Q9Y2U5 MAP3K2 S309 ochoa Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}.
Q9Y2W1 THRAP3 T327 ochoa Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.
Q9Y3P9 RABGAP1 S508 ochoa Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}.
Q9Y4F5 CEP170B S425 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y520 PRRC2C S2036 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y5A6 ZSCAN21 S157 ochoa Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q07231}.
Q9Y5K6 CD2AP S554 ochoa CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.
Q9Y5S2 CDC42BPB S1690 ochoa|psp Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Q9Y6R4 MAP3K4 S1274 ochoa Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
Q00613 HSF1 S375 Sugiyama Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}.
Q99626 CDX2 S295 SIGNOR Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}.
Download
reactome_id name p -log10_p
R-HSA-2980766 Nuclear Envelope Breakdown 0.000007 5.151
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.000094 4.026
R-HSA-68875 Mitotic Prophase 0.000102 3.991
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.000624 3.205
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.000691 3.160
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.000691 3.160
R-HSA-1855170 IPs transport between nucleus and cytosol 0.000839 3.076
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.000839 3.076
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.000921 3.036
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.000921 3.036
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.000737 3.133
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.000537 3.270
R-HSA-180746 Nuclear import of Rev protein 0.001009 2.996
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.001534 2.814
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.001659 2.780
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.001306 2.884
R-HSA-177243 Interactions of Rev with host cellular proteins 0.001659 2.780
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.001659 2.780
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.001417 2.849
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.001534 2.814
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.001306 2.884
R-HSA-1280215 Cytokine Signaling in Immune system 0.001285 2.891
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.001808 2.743
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.001790 2.747
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.002555 2.593
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.002731 2.564
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.002840 2.547
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.003354 2.474
R-HSA-68886 M Phase 0.003936 2.405
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.005169 2.287
R-HSA-8951430 RUNX3 regulates WNT signaling 0.005169 2.287
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.005825 2.235
R-HSA-191859 snRNP Assembly 0.005825 2.235
R-HSA-194441 Metabolism of non-coding RNA 0.005825 2.235
R-HSA-168325 Viral Messenger RNA Synthesis 0.006448 2.191
R-HSA-6784531 tRNA processing in the nucleus 0.006775 2.169
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.007313 2.136
R-HSA-9008059 Interleukin-37 signaling 0.006810 2.167
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.007887 2.103
R-HSA-5689877 Josephin domain DUBs 0.008557 2.068
R-HSA-9661070 Defective translocation of RB1 mutants to the nucleus 0.010502 1.979
R-HSA-5578749 Transcriptional regulation by small RNAs 0.010664 1.972
R-HSA-69278 Cell Cycle, Mitotic 0.009859 2.006
R-HSA-8941326 RUNX2 regulates bone development 0.011001 1.959
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.011976 1.922
R-HSA-913531 Interferon Signaling 0.011198 1.951
R-HSA-1169408 ISG15 antiviral mechanism 0.012062 1.919
R-HSA-4641265 Repression of WNT target genes 0.012698 1.896
R-HSA-8983711 OAS antiviral response 0.012698 1.896
R-HSA-3371556 Cellular response to heat stress 0.014826 1.829
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.013935 1.856
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.014236 1.847
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.014642 1.834
R-HSA-162909 Host Interactions of HIV factors 0.016142 1.792
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.017541 1.756
R-HSA-77042 Formation of editosomes by ADAR proteins 0.020894 1.680
R-HSA-373756 SDK interactions 0.020894 1.680
R-HSA-201681 TCF dependent signaling in response to WNT 0.021051 1.677
R-HSA-75153 Apoptotic execution phase 0.020042 1.698
R-HSA-449147 Signaling by Interleukins 0.020167 1.695
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.021137 1.675
R-HSA-2028269 Signaling by Hippo 0.023041 1.638
R-HSA-1640170 Cell Cycle 0.023105 1.636
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.025011 1.602
R-HSA-1500931 Cell-Cell communication 0.027143 1.566
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.025011 1.602
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.025347 1.596
R-HSA-162599 Late Phase of HIV Life Cycle 0.028208 1.550
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.028208 1.550
R-HSA-6807004 Negative regulation of MET activity 0.029150 1.535
R-HSA-70171 Glycolysis 0.030852 1.511
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.041354 1.383
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.041354 1.383
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.041354 1.383
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.041354 1.383
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.041354 1.383
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.041354 1.383
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.041354 1.383
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.041354 1.383
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.041354 1.383
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.041354 1.383
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.041354 1.383
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.033542 1.474
R-HSA-75064 mRNA Editing: A to I Conversion 0.041354 1.383
R-HSA-75102 C6 deamination of adenosine 0.041354 1.383
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.033542 1.474
R-HSA-352238 Breakdown of the nuclear lamina 0.031178 1.506
R-HSA-429914 Deadenylation-dependent mRNA decay 0.034706 1.460
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.034706 1.460
R-HSA-162587 HIV Life Cycle 0.039041 1.408
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.038698 1.412
R-HSA-446728 Cell junction organization 0.039876 1.399
R-HSA-1483249 Inositol phosphate metabolism 0.043346 1.363
R-HSA-211000 Gene Silencing by RNA 0.038250 1.417
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.045544 1.342
R-HSA-5693606 DNA Double Strand Break Response 0.045847 1.339
R-HSA-8878171 Transcriptional regulation by RUNX1 0.047465 1.324
R-HSA-162906 HIV Infection 0.048230 1.317
R-HSA-2262752 Cellular responses to stress 0.048822 1.311
R-HSA-9705683 SARS-CoV-2-host interactions 0.049003 1.310
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.050724 1.295
R-HSA-9007101 Rab regulation of trafficking 0.051093 1.292
R-HSA-70326 Glucose metabolism 0.051093 1.292
R-HSA-390650 Histamine receptors 0.051424 1.289
R-HSA-195721 Signaling by WNT 0.053012 1.276
R-HSA-211163 AKT-mediated inactivation of FOXO1A 0.061389 1.212
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.061389 1.212
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.067425 1.171
R-HSA-182971 EGFR downregulation 0.058867 1.230
R-HSA-191650 Regulation of gap junction activity 0.061389 1.212
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 0.061389 1.212
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.061389 1.212
R-HSA-6806834 Signaling by MET 0.067218 1.173
R-HSA-8953897 Cellular responses to stimuli 0.068034 1.167
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.071250 1.147
R-HSA-9706377 FLT3 signaling by CBL mutants 0.071250 1.147
R-HSA-8866376 Reelin signalling pathway 0.071250 1.147
R-HSA-5688426 Deubiquitination 0.072770 1.138
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.090663 1.043
R-HSA-9842640 Signaling by LTK in cancer 0.090663 1.043
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 0.090663 1.043
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.100218 0.999
R-HSA-446107 Type I hemidesmosome assembly 0.109674 0.960
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.146517 0.834
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.164366 0.784
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.164366 0.784
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.190446 0.720
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.190446 0.720
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.190446 0.720
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.207382 0.683
R-HSA-912631 Regulation of signaling by CBL 0.223965 0.650
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.223965 0.650
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.240204 0.619
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.248196 0.605
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.294423 0.531
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.294423 0.531
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.180517 0.743
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.261422 0.583
R-HSA-141424 Amplification of signal from the kinetochores 0.261422 0.583
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.286920 0.542
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.185077 0.733
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.185077 0.733
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.248196 0.605
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.215717 0.666
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.185077 0.733
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.081007 1.091
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.109674 0.960
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.198958 0.701
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.146517 0.834
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.137451 0.862
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.074562 1.127
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.137093 0.863
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.110226 0.958
R-HSA-6802957 Oncogenic MAPK signaling 0.076451 1.117
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.074562 1.127
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.265317 0.576
R-HSA-6803544 Ion influx/efflux at host-pathogen interface 0.128289 0.892
R-HSA-209560 NF-kB is activated and signals survival 0.146517 0.834
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.155488 0.808
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.173151 0.762
R-HSA-113510 E2F mediated regulation of DNA replication 0.223965 0.650
R-HSA-8856828 Clathrin-mediated endocytosis 0.242291 0.616
R-HSA-193639 p75NTR signals via NF-kB 0.181844 0.740
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.210289 0.677
R-HSA-5689603 UCH proteinases 0.222579 0.653
R-HSA-209543 p75NTR recruits signalling complexes 0.155488 0.808
R-HSA-177929 Signaling by EGFR 0.147164 0.832
R-HSA-68882 Mitotic Anaphase 0.106199 0.974
R-HSA-68877 Mitotic Prometaphase 0.187176 0.728
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.107601 0.968
R-HSA-75072 mRNA Editing 0.119030 0.924
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 0.128289 0.892
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.155488 0.808
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.294423 0.531
R-HSA-9664873 Pexophagy 0.128289 0.892
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.271674 0.566
R-HSA-5696398 Nucleotide Excision Repair 0.127608 0.894
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.090663 1.043
R-HSA-205043 NRIF signals cell death from the nucleus 0.173151 0.762
R-HSA-525793 Myogenesis 0.286920 0.542
R-HSA-1295596 Spry regulation of FGF signaling 0.181844 0.740
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.207167 0.684
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.215717 0.666
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.109674 0.960
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.119030 0.924
R-HSA-877312 Regulation of IFNG signaling 0.155488 0.808
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.181844 0.740
R-HSA-9706369 Negative regulation of FLT3 0.190446 0.720
R-HSA-429947 Deadenylation of mRNA 0.271674 0.566
R-HSA-69236 G1 Phase 0.105168 0.978
R-HSA-69231 Cyclin D associated events in G1 0.105168 0.978
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.230320 0.638
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.184293 0.734
R-HSA-8851805 MET activates RAS signaling 0.155488 0.808
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 0.207382 0.683
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.263930 0.579
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.263930 0.579
R-HSA-69202 Cyclin E associated events during G1/S transition 0.199505 0.700
R-HSA-8953854 Metabolism of RNA 0.120928 0.917
R-HSA-1632852 Macroautophagy 0.233924 0.631
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.211009 0.676
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.199505 0.700
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.181844 0.740
R-HSA-5689901 Metalloprotease DUBs 0.286920 0.542
R-HSA-9609690 HCMV Early Events 0.193539 0.713
R-HSA-5683057 MAPK family signaling cascades 0.193588 0.713
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.199505 0.700
R-HSA-9663891 Selective autophagy 0.273107 0.564
R-HSA-373753 Nephrin family interactions 0.232127 0.634
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.218716 0.660
R-HSA-9018519 Estrogen-dependent gene expression 0.220104 0.657
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.263930 0.579
R-HSA-5687128 MAPK6/MAPK4 signaling 0.076451 1.117
R-HSA-9612973 Autophagy 0.279044 0.554
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.100218 0.999
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.128289 0.892
R-HSA-8854214 TBC/RABGAPs 0.101837 0.992
R-HSA-75109 Triglyceride biosynthesis 0.294423 0.531
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.111942 0.951
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.261422 0.583
R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.232127 0.634
R-HSA-3214847 HATs acetylate histones 0.111616 0.952
R-HSA-199991 Membrane Trafficking 0.276451 0.558
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.240204 0.619
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.240204 0.619
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.264828 0.577
R-HSA-1433559 Regulation of KIT signaling 0.173151 0.762
R-HSA-5693532 DNA Double-Strand Break Repair 0.270504 0.568
R-HSA-936837 Ion transport by P-type ATPases 0.176753 0.753
R-HSA-430116 GP1b-IX-V activation signalling 0.119030 0.924
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.122245 0.913
R-HSA-1483213 Synthesis of PE 0.294423 0.531
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.207167 0.684
R-HSA-9610379 HCMV Late Events 0.115409 0.938
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.193539 0.713
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.109674 0.960
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.119030 0.924
R-HSA-9762292 Regulation of CDH11 function 0.128289 0.892
R-HSA-446353 Cell-extracellular matrix interactions 0.181844 0.740
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.250707 0.601
R-HSA-9711123 Cellular response to chemical stress 0.190089 0.721
R-HSA-421270 Cell-cell junction organization 0.160386 0.795
R-HSA-1643713 Signaling by EGFR in Cancer 0.286920 0.542
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.161833 0.791
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.161833 0.791
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.161833 0.791
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.161833 0.791
R-HSA-418990 Adherens junctions interactions 0.244330 0.612
R-HSA-8878166 Transcriptional regulation by RUNX2 0.166889 0.778
R-HSA-168255 Influenza Infection 0.158461 0.800
R-HSA-73887 Death Receptor Signaling 0.110226 0.958
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.079425 1.100
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.232127 0.634
R-HSA-9671555 Signaling by PDGFR in disease 0.248196 0.605
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.294423 0.531
R-HSA-162582 Signal Transduction 0.149420 0.826
R-HSA-438064 Post NMDA receptor activation events 0.269212 0.570
R-HSA-9833482 PKR-mediated signaling 0.238079 0.623
R-HSA-4086398 Ca2+ pathway 0.211009 0.676
R-HSA-73894 DNA Repair 0.214829 0.668
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.256104 0.592
R-HSA-3000170 Syndecan interactions 0.263930 0.579
R-HSA-3000157 Laminin interactions 0.279337 0.554
R-HSA-3247509 Chromatin modifying enzymes 0.281266 0.551
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.207382 0.683
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.207382 0.683
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.263930 0.579
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.169265 0.771
R-HSA-446652 Interleukin-1 family signaling 0.106830 0.971
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.161833 0.791
R-HSA-1980143 Signaling by NOTCH1 0.222579 0.653
R-HSA-1059683 Interleukin-6 signaling 0.164366 0.784
R-HSA-9682706 Replication of the SARS-CoV-1 genome 0.164366 0.784
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.172031 0.764
R-HSA-9694686 Replication of the SARS-CoV-2 genome 0.207382 0.683
R-HSA-8863678 Neurodegenerative Diseases 0.271674 0.566
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.271674 0.566
R-HSA-168256 Immune System 0.154869 0.810
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.294423 0.531
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.107199 0.970
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.147164 0.832
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 0.173151 0.762
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 0.223965 0.650
R-HSA-6783589 Interleukin-6 family signaling 0.271674 0.566
R-HSA-9694516 SARS-CoV-2 Infection 0.097663 1.010
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.180517 0.743
R-HSA-9006936 Signaling by TGFB family members 0.290470 0.537
R-HSA-5357905 Regulation of TNFR1 signaling 0.111917 0.951
R-HSA-381038 XBP1(S) activates chaperone genes 0.265317 0.576
R-HSA-381119 Unfolded Protein Response (UPR) 0.228377 0.641
R-HSA-9679506 SARS-CoV Infections 0.264853 0.577
R-HSA-381070 IRE1alpha activates chaperones 0.288675 0.540
R-HSA-9020591 Interleukin-12 signaling 0.222579 0.653
R-HSA-72306 tRNA processing 0.140953 0.851
R-HSA-75893 TNF signaling 0.147164 0.832
R-HSA-5619102 SLC transporter disorders 0.133436 0.875
R-HSA-447115 Interleukin-12 family signaling 0.269212 0.570
R-HSA-109581 Apoptosis 0.296197 0.528
R-HSA-167287 HIV elongation arrest and recovery 0.301848 0.520
R-HSA-167290 Pausing and recovery of HIV elongation 0.301848 0.520
R-HSA-113418 Formation of the Early Elongation Complex 0.301848 0.520
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.301848 0.520
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.301848 0.520
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.301848 0.520
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.301848 0.520
R-HSA-72086 mRNA Capping 0.309196 0.510
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.309196 0.510
R-HSA-210745 Regulation of gene expression in beta cells 0.309196 0.510
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.309196 0.510
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.309196 0.510
R-HSA-5619115 Disorders of transmembrane transporters 0.311888 0.506
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.311951 0.506
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.311951 0.506
R-HSA-6807878 COPI-mediated anterograde transport 0.311951 0.506
R-HSA-8878159 Transcriptional regulation by RUNX3 0.315817 0.501
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.316466 0.500
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.316466 0.500
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.316466 0.500
R-HSA-8863795 Downregulation of ERBB2 signaling 0.316466 0.500
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.316466 0.500
R-HSA-4839726 Chromatin organization 0.316631 0.499
R-HSA-9609646 HCMV Infection 0.319005 0.496
R-HSA-597592 Post-translational protein modification 0.319520 0.496
R-HSA-193704 p75 NTR receptor-mediated signalling 0.323533 0.490
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.323660 0.490
R-HSA-69618 Mitotic Spindle Checkpoint 0.327384 0.485
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.327784 0.484
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.330659 0.481
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.330659 0.481
R-HSA-9675126 Diseases of mitotic cell cycle 0.330779 0.480
R-HSA-1538133 G0 and Early G1 0.330779 0.480
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.335066 0.475
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.336407 0.473
R-HSA-354192 Integrin signaling 0.337824 0.471
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.337824 0.471
R-HSA-9930044 Nuclear RNA decay 0.337824 0.471
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.337824 0.471
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.337824 0.471
R-HSA-9733709 Cardiogenesis 0.337824 0.471
R-HSA-159418 Recycling of bile acids and salts 0.337824 0.471
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.337824 0.471
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.342724 0.465
R-HSA-5223345 Miscellaneous transport and binding events 0.344795 0.462
R-HSA-2559583 Cellular Senescence 0.350765 0.455
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.351693 0.454
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.351693 0.454
R-HSA-5205647 Mitophagy 0.351693 0.454
R-HSA-5686938 Regulation of TLR by endogenous ligand 0.351693 0.454
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.351693 0.454
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.357954 0.446
R-HSA-9700206 Signaling by ALK in cancer 0.357954 0.446
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.358518 0.445
R-HSA-381042 PERK regulates gene expression 0.358518 0.445
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.358518 0.445
R-HSA-2559585 Oncogene Induced Senescence 0.358518 0.445
R-HSA-3371511 HSF1 activation 0.365273 0.437
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.365273 0.437
R-HSA-9682385 FLT3 signaling in disease 0.365273 0.437
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.371956 0.430
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.378570 0.422
R-HSA-168898 Toll-like Receptor Cascades 0.382214 0.418
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.384289 0.415
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.385114 0.414
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.385114 0.414
R-HSA-8953750 Transcriptional Regulation by E2F6 0.385114 0.414
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.385114 0.414
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.385114 0.414
R-HSA-201556 Signaling by ALK 0.385114 0.414
R-HSA-3371568 Attenuation phase 0.391590 0.407
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.391590 0.407
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.391590 0.407
R-HSA-167169 HIV Transcription Elongation 0.391590 0.407
R-HSA-5260271 Diseases of Immune System 0.391590 0.407
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.391590 0.407
R-HSA-9646399 Aggrephagy 0.391590 0.407
R-HSA-909733 Interferon alpha/beta signaling 0.395436 0.403
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.397998 0.400
R-HSA-3214841 PKMTs methylate histone lysines 0.397998 0.400
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.397998 0.400
R-HSA-9607240 FLT3 Signaling 0.397998 0.400
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.404339 0.393
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.404339 0.393
R-HSA-5674135 MAP2K and MAPK activation 0.404339 0.393
R-HSA-9656223 Signaling by RAF1 mutants 0.404339 0.393
R-HSA-5693538 Homology Directed Repair 0.406491 0.391
R-HSA-389948 Co-inhibition by PD-1 0.407702 0.390
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.410155 0.387
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.410155 0.387
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.410614 0.387
R-HSA-165159 MTOR signalling 0.410614 0.387
R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.410614 0.387
R-HSA-5654743 Signaling by FGFR4 0.416822 0.380
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.416822 0.380
R-HSA-1433557 Signaling by SCF-KIT 0.416822 0.380
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.417449 0.379
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.421079 0.376
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.421079 0.376
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.422966 0.374
R-HSA-375280 Amine ligand-binding receptors 0.422966 0.374
R-HSA-5357801 Programmed Cell Death 0.424525 0.372
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.429046 0.367
R-HSA-5654741 Signaling by FGFR3 0.429046 0.367
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.435061 0.361
R-HSA-9649948 Signaling downstream of RAS mutants 0.435061 0.361
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.435061 0.361
R-HSA-6802949 Signaling by RAS mutants 0.435061 0.361
R-HSA-2299718 Condensation of Prophase Chromosomes 0.435061 0.361
R-HSA-9861718 Regulation of pyruvate metabolism 0.435061 0.361
R-HSA-69206 G1/S Transition 0.435483 0.361
R-HSA-1483191 Synthesis of PC 0.441014 0.356
R-HSA-114608 Platelet degranulation 0.442613 0.354
R-HSA-74160 Gene expression (Transcription) 0.442976 0.354
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.446904 0.350
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.446904 0.350
R-HSA-157858 Gap junction trafficking and regulation 0.452733 0.344
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.452733 0.344
R-HSA-5658442 Regulation of RAS by GAPs 0.458501 0.339
R-HSA-9843745 Adipogenesis 0.460219 0.337
R-HSA-9909396 Circadian clock 0.463702 0.334
R-HSA-8856688 Golgi-to-ER retrograde transport 0.463702 0.334
R-HSA-3371571 HSF1-dependent transactivation 0.464208 0.333
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.467172 0.331
R-HSA-72187 mRNA 3'-end processing 0.469855 0.328
R-HSA-112382 Formation of RNA Pol II elongation complex 0.469855 0.328
R-HSA-6794361 Neurexins and neuroligins 0.469855 0.328
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.469855 0.328
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.469855 0.328
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.475444 0.323
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.475444 0.323
R-HSA-9639288 Amino acids regulate mTORC1 0.475444 0.323
R-HSA-445355 Smooth Muscle Contraction 0.475444 0.323
R-HSA-1221632 Meiotic synapsis 0.475444 0.323
R-HSA-3858494 Beta-catenin independent WNT signaling 0.480917 0.318
R-HSA-212165 Epigenetic regulation of gene expression 0.490667 0.309
R-HSA-193648 NRAGE signals death through JNK 0.491859 0.308
R-HSA-5654736 Signaling by FGFR1 0.491859 0.308
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.491859 0.308
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.497217 0.303
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.502518 0.299
R-HSA-186712 Regulation of beta-cell development 0.507764 0.294
R-HSA-8979227 Triglyceride metabolism 0.507764 0.294
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.507764 0.294
R-HSA-8939211 ESR-mediated signaling 0.510994 0.292
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.512955 0.290
R-HSA-1227986 Signaling by ERBB2 0.512955 0.290
R-HSA-8943724 Regulation of PTEN gene transcription 0.512955 0.290
R-HSA-5653656 Vesicle-mediated transport 0.513909 0.289
R-HSA-73856 RNA Polymerase II Transcription Termination 0.518091 0.286
R-HSA-211976 Endogenous sterols 0.518091 0.286
R-HSA-199977 ER to Golgi Anterograde Transport 0.520824 0.283
R-HSA-9707616 Heme signaling 0.523174 0.281
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.524056 0.281
R-HSA-69242 S Phase 0.524056 0.281
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.528203 0.277
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.528203 0.277
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.528203 0.277
R-HSA-8848021 Signaling by PTK6 0.528203 0.277
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.528203 0.277
R-HSA-9856651 MITF-M-dependent gene expression 0.530478 0.275
R-HSA-8854518 AURKA Activation by TPX2 0.542977 0.265
R-HSA-1989781 PPARA activates gene expression 0.546275 0.263
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.547799 0.261
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.552490 0.258
R-HSA-167172 Transcription of the HIV genome 0.552570 0.258
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.552570 0.258
R-HSA-388841 Regulation of T cell activation by CD28 family 0.559030 0.253
R-HSA-69620 Cell Cycle Checkpoints 0.563922 0.249
R-HSA-5632684 Hedgehog 'on' state 0.566585 0.247
R-HSA-453276 Regulation of mitotic cell cycle 0.566585 0.247
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.566585 0.247
R-HSA-2467813 Separation of Sister Chromatids 0.573769 0.241
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.575685 0.240
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.580163 0.236
R-HSA-69473 G2/M DNA damage checkpoint 0.580163 0.236
R-HSA-380287 Centrosome maturation 0.584595 0.233
R-HSA-8852135 Protein ubiquitination 0.584595 0.233
R-HSA-416482 G alpha (12/13) signalling events 0.597612 0.224
R-HSA-216083 Integrin cell surface interactions 0.597612 0.224
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.601860 0.221
R-HSA-5654738 Signaling by FGFR2 0.606064 0.217
R-HSA-5693607 Processing of DNA double-strand break ends 0.610224 0.215
R-HSA-977225 Amyloid fiber formation 0.610224 0.215
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.610224 0.215
R-HSA-9707564 Cytoprotection by HMOX1 0.618413 0.209
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.622443 0.206
R-HSA-6794362 Protein-protein interactions at synapses 0.626430 0.203
R-HSA-1500620 Meiosis 0.626430 0.203
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.630376 0.200
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.634281 0.198
R-HSA-5673001 RAF/MAP kinase cascade 0.635403 0.197
R-HSA-70268 Pyruvate metabolism 0.638144 0.195
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.641967 0.192
R-HSA-9645723 Diseases of programmed cell death 0.641967 0.192
R-HSA-73857 RNA Polymerase II Transcription 0.644687 0.191
R-HSA-1236974 ER-Phagosome pathway 0.645749 0.190
R-HSA-983712 Ion channel transport 0.646319 0.190
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.649492 0.187
R-HSA-5684996 MAPK1/MAPK3 signaling 0.650378 0.187
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.664075 0.178
R-HSA-1474290 Collagen formation 0.667625 0.175
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.673958 0.171
R-HSA-948021 Transport to the Golgi and subsequent modification 0.678792 0.168
R-HSA-376176 Signaling by ROBO receptors 0.681187 0.167
R-HSA-8957275 Post-translational protein phosphorylation 0.684826 0.164
R-HSA-190236 Signaling by FGFR 0.684826 0.164
R-HSA-9614085 FOXO-mediated transcription 0.688158 0.162
R-HSA-192105 Synthesis of bile acids and bile salts 0.688158 0.162
R-HSA-5610787 Hedgehog 'off' state 0.691455 0.160
R-HSA-9020702 Interleukin-1 signaling 0.694718 0.158
R-HSA-2559580 Oxidative Stress Induced Senescence 0.697946 0.156
R-HSA-212436 Generic Transcription Pathway 0.698134 0.156
R-HSA-9860931 Response of endothelial cells to shear stress 0.704302 0.152
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.704347 0.152
R-HSA-9730414 MITF-M-regulated melanocyte development 0.706585 0.151
R-HSA-1474244 Extracellular matrix organization 0.718670 0.143
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.719614 0.143
R-HSA-1236975 Antigen processing-Cross presentation 0.719614 0.143
R-HSA-8951664 Neddylation 0.723986 0.140
R-HSA-194068 Bile acid and bile salt metabolism 0.725516 0.139
R-HSA-6803157 Antimicrobial peptides 0.728421 0.138
R-HSA-9855142 Cellular responses to mechanical stimuli 0.736952 0.133
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.739736 0.131
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.742491 0.129
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.742491 0.129
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.742704 0.129
R-HSA-373760 L1CAM interactions 0.747914 0.126
R-HSA-1592230 Mitochondrial biogenesis 0.750583 0.125
R-HSA-2980736 Peptide hormone metabolism 0.750583 0.125
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.753223 0.123
R-HSA-3700989 Transcriptional Regulation by TP53 0.757185 0.121
R-HSA-157118 Signaling by NOTCH 0.761860 0.118
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.766016 0.116
R-HSA-9006931 Signaling by Nuclear Receptors 0.771698 0.113
R-HSA-9824446 Viral Infection Pathways 0.777657 0.109
R-HSA-69481 G2/M Checkpoints 0.778149 0.109
R-HSA-1474165 Reproduction 0.787403 0.104
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.801885 0.096
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.802718 0.095
R-HSA-5358351 Signaling by Hedgehog 0.806846 0.093
R-HSA-6807070 PTEN Regulation 0.808894 0.092
R-HSA-9664417 Leishmania phagocytosis 0.810921 0.091
R-HSA-9664407 Parasite infection 0.810921 0.091
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.810921 0.091
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.812926 0.090
R-HSA-76002 Platelet activation, signaling and aggregation 0.818514 0.087
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.829970 0.081
R-HSA-9679191 Potential therapeutics for SARS 0.831850 0.080
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.835400 0.078
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.845609 0.073
R-HSA-9711097 Cellular response to starvation 0.845609 0.073
R-HSA-1257604 PIP3 activates AKT signaling 0.847208 0.072
R-HSA-877300 Interferon gamma signaling 0.847248 0.072
R-HSA-5633007 Regulation of TP53 Activity 0.848870 0.071
R-HSA-446203 Asparagine N-linked glycosylation 0.849129 0.071
R-HSA-422475 Axon guidance 0.851353 0.070
R-HSA-109582 Hemostasis 0.856976 0.067
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.859754 0.066
R-HSA-392499 Metabolism of proteins 0.866776 0.062
R-HSA-5689880 Ub-specific processing proteases 0.869858 0.061
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.871242 0.060
R-HSA-9678108 SARS-CoV-1 Infection 0.872610 0.059
R-HSA-1852241 Organelle biogenesis and maintenance 0.875985 0.058
R-HSA-112315 Transmission across Chemical Synapses 0.879083 0.056
R-HSA-1280218 Adaptive Immune System 0.881507 0.055
R-HSA-6798695 Neutrophil degranulation 0.882918 0.054
R-HSA-9675108 Nervous system development 0.883283 0.054
R-HSA-69275 G2/M Transition 0.886742 0.052
R-HSA-453274 Mitotic G2-G2/M phases 0.889139 0.051
R-HSA-5617833 Cilium Assembly 0.891485 0.050
R-HSA-112316 Neuronal System 0.892062 0.050
R-HSA-9006925 Intracellular signaling by second messengers 0.897108 0.047
R-HSA-1483206 Glycerophospholipid biosynthesis 0.905577 0.043
R-HSA-397014 Muscle contraction 0.915165 0.039
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.929295 0.032
R-HSA-9824439 Bacterial Infection Pathways 0.932740 0.030
R-HSA-1266738 Developmental Biology 0.934670 0.029
R-HSA-202733 Cell surface interactions at the vascular wall 0.935109 0.029
R-HSA-1643685 Disease 0.941410 0.026
R-HSA-9734767 Developmental Cell Lineages 0.950915 0.022
R-HSA-416476 G alpha (q) signalling events 0.951440 0.022
R-HSA-5663205 Infectious disease 0.955844 0.020
R-HSA-211945 Phase I - Functionalization of compounds 0.958226 0.019
R-HSA-9824443 Parasitic Infection Pathways 0.959552 0.018
R-HSA-9658195 Leishmania infection 0.959552 0.018
R-HSA-1483257 Phospholipid metabolism 0.965210 0.015
R-HSA-8957322 Metabolism of steroids 0.974548 0.011
R-HSA-168249 Innate Immune System 0.977056 0.010
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.978815 0.009
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.988188 0.005
R-HSA-418594 G alpha (i) signalling events 0.989740 0.004
R-HSA-388396 GPCR downstream signalling 0.991121 0.004
R-HSA-372790 Signaling by GPCR 0.995751 0.002
R-HSA-211859 Biological oxidations 0.997098 0.001
R-HSA-500792 GPCR ligand binding 0.998591 0.001
R-HSA-382551 Transport of small molecules 0.998636 0.001
R-HSA-9752946 Expression and translocation of olfactory receptors 0.999850 0.000
R-HSA-381753 Olfactory Signaling Pathway 0.999934 0.000
R-HSA-556833 Metabolism of lipids 0.999991 0.000
R-HSA-9709957 Sensory Perception 0.999999 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.834 0.384 1 0.892
CLK3CLK3 0.822 0.311 1 0.855
COTCOT 0.814 0.147 2 0.751
CDK1CDK1 0.812 0.370 1 0.868
DYRK2DYRK2 0.810 0.336 1 0.909
GRK1GRK1 0.808 0.205 -2 0.811
JNK2JNK2 0.807 0.380 1 0.862
DYRK4DYRK4 0.806 0.362 1 0.886
MOSMOS 0.805 0.181 1 0.750
CDK8CDK8 0.805 0.321 1 0.890
NLKNLK 0.805 0.289 1 0.882
HIPK2HIPK2 0.805 0.330 1 0.879
P38BP38B 0.805 0.382 1 0.863
CDK19CDK19 0.804 0.324 1 0.877
JNK3JNK3 0.804 0.369 1 0.874
HIPK4HIPK4 0.804 0.224 1 0.870
MTORMTOR 0.803 0.164 1 0.740
CDK18CDK18 0.802 0.334 1 0.859
P38DP38D 0.802 0.385 1 0.849
CLK2CLK2 0.801 0.258 -3 0.680
ERK5ERK5 0.801 0.183 1 0.833
SRPK1SRPK1 0.801 0.152 -3 0.684
ERK1ERK1 0.801 0.353 1 0.863
P38GP38G 0.800 0.353 1 0.828
CDC7CDC7 0.798 0.018 1 0.708
CDK7CDK7 0.797 0.291 1 0.891
IKKBIKKB 0.797 0.058 -2 0.712
CDK17CDK17 0.797 0.329 1 0.826
P38AP38A 0.796 0.345 1 0.889
CDK13CDK13 0.794 0.289 1 0.877
CDK3CDK3 0.793 0.304 1 0.841
HIPK1HIPK1 0.793 0.273 1 0.915
PRPKPRPK 0.791 -0.059 -1 0.813
SKMLCKSKMLCK 0.791 0.069 -2 0.858
PIM3PIM3 0.791 0.006 -3 0.771
ATRATR 0.790 0.040 1 0.713
JNK1JNK1 0.790 0.341 1 0.849
RAF1RAF1 0.790 0.001 1 0.691
CDK14CDK14 0.790 0.313 1 0.875
CDK5CDK5 0.790 0.292 1 0.892
ICKICK 0.789 0.166 -3 0.774
CDKL1CDKL1 0.789 0.071 -3 0.739
CDKL5CDKL5 0.789 0.093 -3 0.728
RIPK3RIPK3 0.789 0.043 3 0.764
DSTYKDSTYK 0.788 -0.003 2 0.758
GRK7GRK7 0.788 0.146 1 0.646
CDK12CDK12 0.788 0.290 1 0.863
CK1ECK1E 0.788 0.176 -3 0.632
CLK4CLK4 0.788 0.168 -3 0.708
CAMK2GCAMK2G 0.787 -0.007 2 0.709
CK1DCK1D 0.787 0.211 -3 0.594
BMPR1BBMPR1B 0.787 0.116 1 0.671
ERK2ERK2 0.787 0.313 1 0.872
GRK5GRK5 0.787 0.032 -3 0.839
NDR2NDR2 0.786 -0.030 -3 0.774
CDK10CDK10 0.786 0.298 1 0.871
PDHK4PDHK4 0.786 -0.127 1 0.732
CDK16CDK16 0.785 0.305 1 0.836
DYRK1BDYRK1B 0.785 0.275 1 0.884
CHAK2CHAK2 0.785 0.029 -1 0.804
FAM20CFAM20C 0.784 0.047 2 0.574
IKKAIKKA 0.784 0.016 -2 0.704
GRK6GRK6 0.783 0.065 1 0.686
BMPR2BMPR2 0.783 -0.073 -2 0.837
PRP4PRP4 0.781 0.220 -3 0.724
CAMK1BCAMK1B 0.781 -0.044 -3 0.803
DYRK1ADYRK1A 0.781 0.229 1 0.890
CK1A2CK1A2 0.781 0.189 -3 0.591
IKKEIKKE 0.781 -0.070 1 0.594
SRPK2SRPK2 0.780 0.086 -3 0.607
TBK1TBK1 0.780 -0.096 1 0.597
MLK1MLK1 0.780 -0.008 2 0.656
SRPK3SRPK3 0.780 0.097 -3 0.659
CLK1CLK1 0.780 0.156 -3 0.678
DYRK3DYRK3 0.780 0.219 1 0.908
MST4MST4 0.779 -0.027 2 0.704
GCN2GCN2 0.779 -0.152 2 0.656
CDK9CDK9 0.778 0.254 1 0.880
GRK4GRK4 0.778 0.013 -2 0.817
CDK2CDK2 0.777 0.207 1 0.872
WNK1WNK1 0.776 -0.055 -2 0.872
GSK3AGSK3A 0.776 0.196 4 0.612
DLKDLK 0.776 0.019 1 0.694
MAKMAK 0.776 0.268 -2 0.850
PIM1PIM1 0.776 0.002 -3 0.728
HIPK3HIPK3 0.775 0.225 1 0.887
NEK6NEK6 0.775 -0.078 -2 0.812
CAMLCKCAMLCK 0.775 -0.036 -2 0.830
AURCAURC 0.774 0.025 -2 0.656
DAPK2DAPK2 0.774 -0.039 -3 0.806
ULK2ULK2 0.774 -0.184 2 0.625
NEK7NEK7 0.774 -0.113 -3 0.828
RSK2RSK2 0.774 -0.023 -3 0.698
NDR1NDR1 0.773 -0.079 -3 0.768
NIKNIK 0.773 -0.108 -3 0.824
PDHK1PDHK1 0.773 -0.205 1 0.713
ATMATM 0.772 -0.003 1 0.649
MASTLMASTL 0.772 -0.134 -2 0.794
HUNKHUNK 0.771 -0.086 2 0.716
PKN2PKN2 0.771 -0.040 -3 0.783
MLK3MLK3 0.771 -0.002 2 0.587
CK1G1CK1G1 0.770 0.121 -3 0.621
TGFBR1TGFBR1 0.770 -0.002 -2 0.738
NUAK2NUAK2 0.770 -0.053 -3 0.786
TGFBR2TGFBR2 0.769 -0.108 -2 0.743
RIPK1RIPK1 0.769 -0.081 1 0.675
PKACGPKACG 0.769 -0.033 -2 0.737
ACVR2BACVR2B 0.769 0.035 -2 0.741
TTBK2TTBK2 0.768 -0.072 2 0.565
P90RSKP90RSK 0.767 -0.056 -3 0.702
PAK1PAK1 0.767 -0.029 -2 0.793
MARK4MARK4 0.767 -0.080 4 0.847
PRKD1PRKD1 0.767 -0.092 -3 0.744
ALK4ALK4 0.767 -0.043 -2 0.768
ANKRD3ANKRD3 0.767 -0.096 1 0.712
GRK2GRK2 0.767 0.034 -2 0.702
SMG1SMG1 0.766 -0.008 1 0.674
ULK1ULK1 0.766 -0.166 -3 0.807
BCKDKBCKDK 0.766 -0.146 -1 0.725
PKN3PKN3 0.766 -0.110 -3 0.762
MLK2MLK2 0.766 -0.095 2 0.656
PRKD2PRKD2 0.766 -0.054 -3 0.698
GSK3BGSK3B 0.766 0.114 4 0.606
BMPR1ABMPR1A 0.766 0.059 1 0.649
ALK2ALK2 0.765 0.009 -2 0.759
LATS1LATS1 0.765 -0.015 -3 0.781
MEKK3MEKK3 0.765 0.070 1 0.675
CAMK2BCAMK2B 0.765 -0.033 2 0.702
PKCDPKCD 0.764 -0.076 2 0.625
CDK6CDK6 0.764 0.274 1 0.867
ACVR2AACVR2A 0.764 0.004 -2 0.725
PASKPASK 0.764 0.098 -3 0.794
CAMK2ACAMK2A 0.764 -0.018 2 0.726
CK1ACK1A 0.764 0.199 -3 0.514
PRKXPRKX 0.764 0.033 -3 0.621
PLK1PLK1 0.764 -0.051 -2 0.746
CAMK2DCAMK2D 0.764 -0.113 -3 0.775
PKACBPKACB 0.763 0.009 -2 0.669
WNK3WNK3 0.763 -0.196 1 0.669
VRK2VRK2 0.763 -0.045 1 0.782
MEK1MEK1 0.763 -0.062 2 0.722
P70S6KBP70S6KB 0.763 -0.070 -3 0.731
LATS2LATS2 0.762 -0.097 -5 0.632
RSK3RSK3 0.762 -0.069 -3 0.686
IRE1IRE1 0.762 -0.088 1 0.675
NEK9NEK9 0.762 -0.167 2 0.661
PKRPKR 0.762 -0.056 1 0.713
DNAPKDNAPK 0.762 -0.002 1 0.595
MLK4MLK4 0.762 -0.043 2 0.566
YSK4YSK4 0.761 -0.063 1 0.639
GAKGAK 0.761 0.165 1 0.757
AMPKA1AMPKA1 0.761 -0.120 -3 0.793
RSK4RSK4 0.761 -0.018 -3 0.669
GRK3GRK3 0.761 0.060 -2 0.667
MYLK4MYLK4 0.761 -0.012 -2 0.764
MSK1MSK1 0.760 -0.006 -3 0.682
DRAK1DRAK1 0.759 0.001 1 0.606
CDK4CDK4 0.759 0.267 1 0.858
PKCGPKCG 0.759 -0.055 2 0.586
PAK3PAK3 0.759 -0.084 -2 0.779
MPSK1MPSK1 0.759 0.063 1 0.727
MST3MST3 0.758 0.033 2 0.700
PKCBPKCB 0.758 -0.055 2 0.572
CK2A2CK2A2 0.758 0.083 1 0.590
TLK2TLK2 0.757 -0.065 1 0.657
AURBAURB 0.757 -0.023 -2 0.651
ERK7ERK7 0.757 0.071 2 0.417
MSK2MSK2 0.757 -0.061 -3 0.678
MAPKAPK2MAPKAPK2 0.757 -0.075 -3 0.663
PAK2PAK2 0.757 -0.060 -2 0.775
MOKMOK 0.757 0.188 1 0.888
PLK3PLK3 0.756 -0.046 2 0.697
TSSK2TSSK2 0.756 -0.133 -5 0.711
AURAAURA 0.756 -0.007 -2 0.621
MAPKAPK3MAPKAPK3 0.756 -0.130 -3 0.706
PKCAPKCA 0.756 -0.058 2 0.565
PINK1PINK1 0.756 -0.011 1 0.804
NIM1NIM1 0.756 -0.141 3 0.754
PKCZPKCZ 0.755 -0.069 2 0.608
MNK2MNK2 0.754 -0.080 -2 0.764
CHAK1CHAK1 0.754 -0.105 2 0.617
MNK1MNK1 0.754 -0.062 -2 0.768
CAMK4CAMK4 0.752 -0.147 -3 0.761
CK2A1CK2A1 0.752 0.090 1 0.569
PAK6PAK6 0.752 -0.044 -2 0.698
PKG2PKG2 0.752 -0.041 -2 0.671
AKT2AKT2 0.752 -0.019 -3 0.625
AMPKA2AMPKA2 0.751 -0.124 -3 0.757
TSSK1TSSK1 0.751 -0.127 -3 0.803
MEK5MEK5 0.751 -0.118 2 0.678
QSKQSK 0.751 -0.079 4 0.823
MEKK2MEKK2 0.750 -0.065 2 0.639
TAO3TAO3 0.750 -0.009 1 0.673
PLK4PLK4 0.749 -0.112 2 0.514
PIM2PIM2 0.749 -0.045 -3 0.681
MARK3MARK3 0.749 -0.052 4 0.789
IRE2IRE2 0.749 -0.137 2 0.574
QIKQIK 0.748 -0.146 -3 0.777
NEK2NEK2 0.748 -0.161 2 0.638
PKCHPKCH 0.748 -0.102 2 0.554
NEK11NEK11 0.748 -0.002 1 0.654
SGK3SGK3 0.747 -0.060 -3 0.697
BRAFBRAF 0.747 -0.134 -4 0.549
ZAKZAK 0.747 -0.109 1 0.652
NEK5NEK5 0.747 -0.097 1 0.687
PRKD3PRKD3 0.747 -0.100 -3 0.669
MEKK1MEKK1 0.745 -0.138 1 0.683
CAMK1GCAMK1G 0.745 -0.070 -3 0.696
SMMLCKSMMLCK 0.745 -0.056 -3 0.751
GCKGCK 0.744 0.026 1 0.661
TLK1TLK1 0.744 -0.109 -2 0.786
PLK2PLK2 0.743 0.017 -3 0.738
PHKG1PHKG1 0.743 -0.143 -3 0.760
LKB1LKB1 0.743 -0.055 -3 0.793
TTBK1TTBK1 0.742 -0.106 2 0.509
WNK4WNK4 0.742 -0.148 -2 0.868
PERKPERK 0.742 -0.184 -2 0.789
SIKSIK 0.742 -0.112 -3 0.699
MARK2MARK2 0.741 -0.093 4 0.745
PKACAPKACA 0.741 -0.028 -2 0.617
MELKMELK 0.741 -0.178 -3 0.734
IRAK4IRAK4 0.740 -0.140 1 0.669
HPK1HPK1 0.739 0.009 1 0.649
DCAMKL1DCAMKL1 0.739 -0.106 -3 0.716
NUAK1NUAK1 0.739 -0.150 -3 0.723
CAMKK1CAMKK1 0.739 -0.115 -2 0.726
BRSK1BRSK1 0.739 -0.130 -3 0.719
DAPK3DAPK3 0.739 -0.033 -3 0.736
TAK1TAK1 0.738 0.006 1 0.661
MAPKAPK5MAPKAPK5 0.738 -0.151 -3 0.651
NEK8NEK8 0.738 -0.125 2 0.652
DAPK1DAPK1 0.738 -0.010 -3 0.721
MARK1MARK1 0.738 -0.107 4 0.804
HRIHRI 0.737 -0.223 -2 0.802
SNRKSNRK 0.737 -0.204 2 0.544
PDK1PDK1 0.736 -0.089 1 0.656
CAMKK2CAMKK2 0.736 -0.126 -2 0.721
BRSK2BRSK2 0.735 -0.164 -3 0.747
AKT1AKT1 0.735 -0.047 -3 0.642
PKCEPKCE 0.735 -0.050 2 0.570
STK33STK33 0.734 -0.069 2 0.530
MAP3K15MAP3K15 0.734 -0.088 1 0.641
MST2MST2 0.734 -0.089 1 0.667
PAK5PAK5 0.734 -0.064 -2 0.648
TAO2TAO2 0.733 -0.116 2 0.680
PAK4PAK4 0.733 -0.049 -2 0.650
PKCIPKCI 0.733 -0.091 2 0.579
YANK3YANK3 0.733 0.009 2 0.386
MINKMINK 0.733 -0.070 1 0.650
CK1G3CK1G3 0.733 0.178 -3 0.473
CHK1CHK1 0.732 -0.201 -3 0.753
SSTKSSTK 0.732 -0.116 4 0.812
EEF2KEEF2K 0.732 -0.061 3 0.820
DCAMKL2DCAMKL2 0.732 -0.117 -3 0.739
PKCTPKCT 0.732 -0.121 2 0.555
IRAK1IRAK1 0.731 -0.187 -1 0.703
TNIKTNIK 0.731 -0.061 3 0.853
MEKK6MEKK6 0.730 -0.126 1 0.673
HGKHGK 0.729 -0.092 3 0.851
LRRK2LRRK2 0.729 -0.117 2 0.687
KHS2KHS2 0.729 -0.007 1 0.656
NEK4NEK4 0.728 -0.166 1 0.653
ROCK2ROCK2 0.728 -0.040 -3 0.724
VRK1VRK1 0.727 -0.121 2 0.689
PBKPBK 0.727 -0.018 1 0.699
PDHK3_TYRPDHK3_TYR 0.727 0.159 4 0.921
PDHK4_TYRPDHK4_TYR 0.727 0.243 2 0.779
KHS1KHS1 0.727 -0.046 1 0.645
P70S6KP70S6K 0.727 -0.118 -3 0.640
HASPINHASPIN 0.727 0.022 -1 0.723
SLKSLK 0.726 -0.059 -2 0.687
SGK1SGK1 0.726 -0.033 -3 0.546
ALPHAK3ALPHAK3 0.724 0.026 -1 0.744
MRCKBMRCKB 0.724 -0.052 -3 0.671
BMPR2_TYRBMPR2_TYR 0.724 0.183 -1 0.863
MAP2K6_TYRMAP2K6_TYR 0.724 0.211 -1 0.826
AKT3AKT3 0.724 -0.043 -3 0.562
BUB1BUB1 0.724 -0.037 -5 0.644
CAMK1DCAMK1D 0.723 -0.110 -3 0.613
CK1G2CK1G2 0.722 0.166 -3 0.551
NEK1NEK1 0.722 -0.168 1 0.658
PHKG2PHKG2 0.722 -0.170 -3 0.730
DMPK1DMPK1 0.722 -0.016 -3 0.696
MST1MST1 0.722 -0.127 1 0.647
LOKLOK 0.722 -0.118 -2 0.733
MRCKAMRCKA 0.722 -0.070 -3 0.688
PDHK1_TYRPDHK1_TYR 0.722 0.194 -1 0.849
OSR1OSR1 0.721 -0.029 2 0.651
TTKTTK 0.720 -0.027 -2 0.778
MAP2K4_TYRMAP2K4_TYR 0.720 0.144 -1 0.821
RIPK2RIPK2 0.720 -0.178 1 0.606
YSK1YSK1 0.717 -0.128 2 0.631
SBKSBK 0.717 -0.035 -3 0.505
CHK2CHK2 0.716 -0.081 -3 0.569
MEK2MEK2 0.714 -0.227 2 0.657
TESK1_TYRTESK1_TYR 0.714 -0.016 3 0.868
PKN1PKN1 0.713 -0.124 -3 0.657
PKMYT1_TYRPKMYT1_TYR 0.712 -0.022 3 0.849
MAP2K7_TYRMAP2K7_TYR 0.711 -0.052 2 0.729
ASK1ASK1 0.711 -0.112 1 0.633
ROCK1ROCK1 0.710 -0.059 -3 0.687
TXKTXK 0.709 0.104 1 0.693
EPHA6EPHA6 0.709 0.036 -1 0.844
BIKEBIKE 0.709 -0.023 1 0.686
EPHB4EPHB4 0.708 0.028 -1 0.798
MYO3BMYO3B 0.707 -0.097 2 0.650
MYO3AMYO3A 0.706 -0.092 1 0.657
CAMK1ACAMK1A 0.706 -0.115 -3 0.585
BLKBLK 0.706 0.106 -1 0.834
FYNFYN 0.706 0.130 -1 0.834
EPHA4EPHA4 0.705 0.052 2 0.730
YANK2YANK2 0.705 0.018 2 0.397
LIMK2_TYRLIMK2_TYR 0.705 -0.051 -3 0.830
LCKLCK 0.705 0.080 -1 0.831
PTK2PTK2 0.705 0.156 -1 0.817
PINK1_TYRPINK1_TYR 0.704 -0.125 1 0.720
PKG1PKG1 0.704 -0.085 -2 0.581
CRIKCRIK 0.703 -0.074 -3 0.641
NEK3NEK3 0.701 -0.217 1 0.642
YES1YES1 0.701 -0.006 -1 0.803
SYKSYK 0.700 0.162 -1 0.795
ABL2ABL2 0.700 -0.012 -1 0.759
HCKHCK 0.700 0.011 -1 0.816
SRMSSRMS 0.700 0.014 1 0.694
CSF1RCSF1R 0.699 -0.023 3 0.807
RETRET 0.699 -0.109 1 0.678
FLT1FLT1 0.698 0.079 -1 0.798
MST1RMST1R 0.698 -0.105 3 0.824
FGRFGR 0.698 -0.042 1 0.709
KITKIT 0.697 0.015 3 0.804
BMXBMX 0.697 0.038 -1 0.727
METMET 0.696 0.029 3 0.800
ITKITK 0.696 0.022 -1 0.771
EPHB1EPHB1 0.696 -0.016 1 0.692
JAK3JAK3 0.696 -0.039 1 0.660
LIMK1_TYRLIMK1_TYR 0.696 -0.151 2 0.689
EPHB2EPHB2 0.696 -0.004 -1 0.782
TNK2TNK2 0.695 -0.037 3 0.773
ABL1ABL1 0.695 -0.030 -1 0.747
TAO1TAO1 0.695 -0.159 1 0.606
STLK3STLK3 0.695 -0.147 1 0.620
JAK2JAK2 0.695 -0.125 1 0.675
EPHB3EPHB3 0.694 -0.019 -1 0.779
INSRRINSRR 0.694 -0.039 3 0.748
FERFER 0.694 -0.071 1 0.715
AAK1AAK1 0.694 0.003 1 0.620
KDRKDR 0.693 -0.031 3 0.781
DDR1DDR1 0.693 -0.130 4 0.841
TYRO3TYRO3 0.692 -0.146 3 0.795
TYK2TYK2 0.692 -0.214 1 0.669
FGFR2FGFR2 0.692 -0.058 3 0.800
EPHA7EPHA7 0.691 -0.003 2 0.703
ROS1ROS1 0.690 -0.165 3 0.766
SRCSRC 0.690 0.033 -1 0.802
EPHA3EPHA3 0.689 -0.038 2 0.682
LYNLYN 0.688 0.007 3 0.727
FGFR3FGFR3 0.688 -0.005 3 0.777
TECTEC 0.687 -0.044 -1 0.707
MERTKMERTK 0.686 -0.077 3 0.784
EPHA8EPHA8 0.686 0.011 -1 0.799
EPHA5EPHA5 0.686 0.003 2 0.707
ERBB2ERBB2 0.685 -0.052 1 0.627
WEE1_TYRWEE1_TYR 0.685 -0.068 -1 0.719
FRKFRK 0.685 -0.035 -1 0.819
ZAP70ZAP70 0.684 0.112 -1 0.726
FLT3FLT3 0.684 -0.138 3 0.795
TEKTEK 0.684 -0.082 3 0.726
PTK2BPTK2B 0.684 -0.029 -1 0.728
FGFR4FGFR4 0.683 0.017 -1 0.724
JAK1JAK1 0.683 -0.110 1 0.621
BTKBTK 0.682 -0.116 -1 0.725
EGFREGFR 0.682 -0.017 1 0.550
DDR2DDR2 0.682 -0.019 3 0.751
FGFR1FGFR1 0.682 -0.131 3 0.772
EPHA2EPHA2 0.681 0.037 -1 0.768
ERBB4ERBB4 0.681 0.036 1 0.574
NEK10_TYRNEK10_TYR 0.680 -0.155 1 0.569
PDGFRBPDGFRB 0.679 -0.206 3 0.809
AXLAXL 0.679 -0.151 3 0.784
MATKMATK 0.679 -0.054 -1 0.695
TNK1TNK1 0.678 -0.158 3 0.774
EPHA1EPHA1 0.677 -0.107 3 0.781
FLT4FLT4 0.677 -0.103 3 0.765
NTRK1NTRK1 0.677 -0.156 -1 0.751
LTKLTK 0.675 -0.152 3 0.756
TNNI3K_TYRTNNI3K_TYR 0.675 -0.156 1 0.713
CSKCSK 0.675 -0.075 2 0.698
ALKALK 0.674 -0.166 3 0.728
NTRK3NTRK3 0.673 -0.109 -1 0.709
INSRINSR 0.673 -0.126 3 0.725
PTK6PTK6 0.672 -0.199 -1 0.670
PDGFRAPDGFRA 0.671 -0.249 3 0.808
NTRK2NTRK2 0.669 -0.195 3 0.769
IGF1RIGF1R 0.662 -0.100 3 0.660
FESFES 0.657 -0.078 -1 0.689
MUSKMUSK 0.653 -0.166 1 0.540