Motif 468 (n=98)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2706 | ochoa | Snf2 related CREBBP activator protein | None |
| A8CG34 | POM121C | S271 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O15061 | SYNM | S1153 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15234 | CASC3 | S381 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O15516 | CLOCK | S449 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O43182 | ARHGAP6 | S344 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43683 | BUB1 | S314 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60271 | SPAG9 | S279 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60566 | BUB1B | S288 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60716 | CTNND1 | S331 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75995 | SASH3 | S158 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O95251 | KAT7 | S111 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95359 | TACC2 | S1958 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P12270 | TPR | S2061 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P15336 | ATF2 | S321 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P18887 | XRCC1 | S418 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P21333 | FLNA | S2537 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23588 | EIF4B | S507 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P39880 | CUX1 | S1227 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P42331 | ARHGAP25 | S407 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P46013 | MKI67 | S185 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48634 | PRRC2A | S1115 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P52948 | NUP98 | S897 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P67809 | YBX1 | S176 | ochoa|psp | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P78559 | MAP1A | S570 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P80723 | BASP1 | S183 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P80723 | BASP1 | S195 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P80723 | BASP1 | S205 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| Q01082 | SPTBN1 | S2316 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01082 | SPTBN1 | S2319 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01814 | ATP2B2 | S1160 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q05397 | PTK2 | S702 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q08211 | DHX9 | S77 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12872 | SFSWAP | S619 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13112 | CHAF1B | S529 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13796 | SHROOM2 | S933 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14147 | DHX34 | S749 | ochoa | Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34) | Probable ATP-binding RNA helicase required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons (PubMed:25220460, PubMed:33205750). Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3 (PubMed:25220460). Interaction with the RUVBL1-RUVBL2 complex results in loss of nucleotide binding ability and ATP hydrolysis of the complex (PubMed:33205750). Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits (PubMed:33205750). {ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:33205750}. |
| Q14202 | ZMYM3 | S37 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14676 | MDC1 | S1095 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14980 | NUMA1 | S2003 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15811 | ITSN1 | S989 | ochoa | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
| Q6P2E9 | EDC4 | S820 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P2E9 | EDC4 | S892 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P996 | PDXDC1 | S748 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PJE2 | POMZP3 | S29 | ochoa | POM121 and ZP3 fusion protein (POM-ZP3) | None |
| Q6PJG2 | MIDEAS | S645 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6PKG0 | LARP1 | S291 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6PKG0 | LARP1 | S293 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6PKG0 | LARP1 | Y862 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6RW13 | AGTRAP | S138 | ochoa | Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}. |
| Q6ZRS2 | SRCAP | S2883 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7L590 | MCM10 | S93 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z2K8 | GPRIN1 | S118 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q86VP1 | TAX1BP1 | S694 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86VP3 | PACS2 | S340 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86YD5 | LDLRAD3 | S313 | ochoa | Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) | May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}. |
| Q8N2F6 | ARMC10 | S54 | ochoa | Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) | May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}. |
| Q8NHM5 | KDM2B | S483 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8WUA7 | TBC1D22A | S150 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q969T4 | UBE2E3 | S19 | ochoa | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. {ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}. |
| Q96HA1 | POM121 | S294 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96JB2 | COG3 | S525 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96JK2 | DCAF5 | S638 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96MY1 | NOL4L | S387 | ochoa | Nucleolar protein 4-like | None |
| Q96PU5 | NEDD4L | S377 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96T58 | SPEN | S2359 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99460 | PSMD1 | S305 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q99570 | PIK3R4 | S865 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q9BQ67 | GRWD1 | S21 | ochoa | Glutamate-rich WD repeat-containing protein 1 | Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}. |
| Q9BSJ6 | PIMREG | S140 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BXF6 | RAB11FIP5 | S307 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY89 | KIAA1671 | S1608 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYB0 | SHANK3 | S902 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9C0B5 | ZDHHC5 | S305 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0B5 | ZDHHC5 | S307 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9GZU1 | MCOLN1 | Y22 | ochoa | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). {ECO:0000250|UniProtKB:Q99J21, ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347, ECO:0000269|PubMed:15336987, ECO:0000269|PubMed:16978393, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:25733853, ECO:0000269|PubMed:27357649, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:27787197, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:11013137}.; FUNCTION: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. {ECO:0000305|PubMed:21256127}. |
| Q9GZY6 | LAT2 | S55 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H4E7 | DEF6 | S606 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H7N4 | SCAF1 | S535 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H7N4 | SCAF1 | S975 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9NQS7 | INCENP | S411 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NZM3 | ITSN2 | S230 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P1Y6 | PHRF1 | T961 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9UHR4 | BAIAP2L1 | S251 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UID3 | VPS51 | S652 | ochoa | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}. |
| Q9UKV3 | ACIN1 | S675 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV3 | ACIN1 | S676 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULT8 | HECTD1 | S1729 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMN6 | KMT2B | S848 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9Y2H0 | DLGAP4 | S620 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y3C5 | RNF11 | S25 | ochoa | RING finger protein 11 | Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. {ECO:0000269|PubMed:14755250}. |
| Q9Y520 | PRRC2C | S1274 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6R1 | SLC4A4 | S79 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q92733 | PRCC | S278 | Sugiyama | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q04637 | EIF4G1 | S198 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q16222 | UAP1 | S496 | Sugiyama | UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23) | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579). {ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:9603950, ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). {ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). {ECO:0000269|PubMed:9765219}. |
| Q07157 | TJP1 | S1153 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q8TD08 | MAPK15 | S364 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.482576e-07 | 6.829 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.738499e-07 | 6.760 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.738499e-07 | 6.760 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.359808e-07 | 6.627 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.359808e-07 | 6.627 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.732823e-07 | 6.563 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.732823e-07 | 6.563 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.666121e-08 | 7.115 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.846774e-07 | 6.734 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.152953e-07 | 6.501 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.624707e-07 | 6.441 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.128821e-07 | 6.213 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.937142e-07 | 6.159 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.742631e-07 | 6.324 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 6.937142e-07 | 6.159 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 6.937142e-07 | 6.159 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.399352e-07 | 6.268 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 6.128821e-07 | 6.213 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 7.830771e-07 | 6.106 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.058597e-06 | 5.975 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.383033e-06 | 5.859 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.539233e-06 | 5.813 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.112025e-06 | 5.675 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.753353e-06 | 5.426 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.424254e-06 | 5.354 |
| R-HSA-191859 | snRNP Assembly | 5.252198e-06 | 5.280 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.252198e-06 | 5.280 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.201828e-06 | 5.207 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.726359e-06 | 5.172 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 9.768990e-06 | 5.010 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.423660e-05 | 4.847 |
| R-HSA-68875 | Mitotic Prophase | 2.725364e-05 | 4.565 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.279630e-05 | 4.484 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.324795e-05 | 4.478 |
| R-HSA-68886 | M Phase | 5.789547e-05 | 4.237 |
| R-HSA-913531 | Interferon Signaling | 5.918304e-05 | 4.228 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.240063e-05 | 4.084 |
| R-HSA-70171 | Glycolysis | 8.663380e-05 | 4.062 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.544781e-05 | 4.020 |
| R-HSA-8953854 | Metabolism of RNA | 1.095039e-04 | 3.961 |
| R-HSA-211000 | Gene Silencing by RNA | 1.262462e-04 | 3.899 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.353194e-04 | 3.869 |
| R-HSA-162587 | HIV Life Cycle | 1.427511e-04 | 3.845 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.575210e-04 | 3.803 |
| R-HSA-5619102 | SLC transporter disorders | 1.999908e-04 | 3.699 |
| R-HSA-162906 | HIV Infection | 1.999992e-04 | 3.699 |
| R-HSA-70326 | Glucose metabolism | 2.112825e-04 | 3.675 |
| R-HSA-3371556 | Cellular response to heat stress | 2.479380e-04 | 3.606 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.359091e-04 | 3.474 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.865119e-04 | 3.413 |
| R-HSA-1640170 | Cell Cycle | 7.883026e-04 | 3.103 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 9.547074e-04 | 3.020 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.041595e-04 | 3.044 |
| R-HSA-9610379 | HCMV Late Events | 9.588770e-04 | 3.018 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.640496e-04 | 3.016 |
| R-HSA-429947 | Deadenylation of mRNA | 9.949698e-04 | 3.002 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.253932e-03 | 2.902 |
| R-HSA-72306 | tRNA processing | 1.416734e-03 | 2.849 |
| R-HSA-168255 | Influenza Infection | 1.788907e-03 | 2.747 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.948777e-03 | 2.710 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.139760e-03 | 2.670 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.363136e-03 | 2.627 |
| R-HSA-9609690 | HCMV Early Events | 2.689304e-03 | 2.570 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.244686e-03 | 2.489 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.244686e-03 | 2.489 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.331854e-03 | 2.477 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.750957e-03 | 2.426 |
| R-HSA-9679506 | SARS-CoV Infections | 3.917226e-03 | 2.407 |
| R-HSA-68882 | Mitotic Anaphase | 4.227905e-03 | 2.374 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 4.281882e-03 | 2.368 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 4.851652e-03 | 2.314 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.314574e-03 | 2.365 |
| R-HSA-75153 | Apoptotic execution phase | 5.195543e-03 | 2.284 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.811169e-03 | 2.236 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.470562e-03 | 2.189 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.819375e-03 | 2.107 |
| R-HSA-9609646 | HCMV Infection | 7.979385e-03 | 2.098 |
| R-HSA-9707616 | Heme signaling | 1.051788e-02 | 1.978 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.132701e-02 | 1.946 |
| R-HSA-68877 | Mitotic Prometaphase | 1.195729e-02 | 1.922 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.218152e-02 | 1.914 |
| R-HSA-72172 | mRNA Splicing | 1.483936e-02 | 1.829 |
| R-HSA-9909396 | Circadian clock | 1.537226e-02 | 1.813 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.413857e-02 | 1.850 |
| R-HSA-74160 | Gene expression (Transcription) | 1.396745e-02 | 1.855 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.816481e-02 | 1.741 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.816481e-02 | 1.741 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 1.900779e-02 | 1.721 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.146386e-02 | 1.668 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.263306e-02 | 1.645 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.399331e-02 | 1.620 |
| R-HSA-109581 | Apoptosis | 2.886705e-02 | 1.540 |
| R-HSA-4839726 | Chromatin organization | 2.969360e-02 | 1.527 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.135137e-02 | 1.504 |
| R-HSA-3214847 | HATs acetylate histones | 3.403570e-02 | 1.468 |
| R-HSA-191650 | Regulation of gap junction activity | 3.765772e-02 | 1.424 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 4.379600e-02 | 1.359 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 4.379600e-02 | 1.359 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 3.765772e-02 | 1.424 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.972472e-02 | 1.401 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.419389e-02 | 1.355 |
| R-HSA-165159 | MTOR signalling | 4.119427e-02 | 1.385 |
| R-HSA-983712 | Ion channel transport | 4.506619e-02 | 1.346 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.884004e-02 | 1.311 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 4.989550e-02 | 1.302 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 4.989550e-02 | 1.302 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 4.989550e-02 | 1.302 |
| R-HSA-9766229 | Degradation of CDH1 | 5.203174e-02 | 1.284 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.695475e-02 | 1.244 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.863072e-02 | 1.232 |
| R-HSA-72649 | Translation initiation complex formation | 6.032371e-02 | 1.220 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.375958e-02 | 1.195 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.726017e-02 | 1.172 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.203342e-02 | 1.207 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.375958e-02 | 1.195 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.550192e-02 | 1.184 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.695475e-02 | 1.244 |
| R-HSA-1462054 | Alpha-defensins | 6.796378e-02 | 1.168 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.375958e-02 | 1.195 |
| R-HSA-5578775 | Ion homeostasis | 6.375958e-02 | 1.195 |
| R-HSA-69481 | G2/M Checkpoints | 6.342018e-02 | 1.198 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.824123e-02 | 1.235 |
| R-HSA-1500931 | Cell-Cell communication | 6.508713e-02 | 1.187 |
| R-HSA-422475 | Axon guidance | 7.139577e-02 | 1.146 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 6.796378e-02 | 1.168 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.375958e-02 | 1.195 |
| R-HSA-162582 | Signal Transduction | 6.934583e-02 | 1.159 |
| R-HSA-9824446 | Viral Infection Pathways | 6.311072e-02 | 1.200 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.921958e-02 | 1.160 |
| R-HSA-2262752 | Cellular responses to stress | 6.858944e-02 | 1.164 |
| R-HSA-5357801 | Programmed Cell Death | 5.694553e-02 | 1.245 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.371983e-02 | 1.132 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 7.391059e-02 | 1.131 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 7.391059e-02 | 1.131 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 7.391059e-02 | 1.131 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.444687e-02 | 1.128 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.444687e-02 | 1.128 |
| R-HSA-936837 | Ion transport by P-type ATPases | 7.812879e-02 | 1.107 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 9.152651e-02 | 1.038 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.201519e-01 | 0.920 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.257688e-01 | 0.900 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.257688e-01 | 0.900 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.313503e-01 | 0.882 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.533254e-01 | 0.814 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.852598e-01 | 0.732 |
| R-HSA-8874081 | MET activates PTK2 signaling | 1.852598e-01 | 0.732 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.309380e-01 | 0.637 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.884559e-01 | 0.725 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.884559e-01 | 0.725 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.144992e-01 | 0.941 |
| R-HSA-9762292 | Regulation of CDH11 function | 7.981983e-02 | 1.098 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 8.569172e-02 | 1.067 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.058838e-01 | 0.686 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.257688e-01 | 0.900 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.289920e-01 | 0.889 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.852598e-01 | 0.732 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.368965e-01 | 0.864 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.587326e-01 | 0.799 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.904650e-01 | 0.720 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.109584e-01 | 0.676 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.109584e-01 | 0.676 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 8.757563e-02 | 1.058 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.500375e-01 | 0.824 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.023307e-01 | 0.694 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.023307e-01 | 0.694 |
| R-HSA-525793 | Myogenesis | 1.852598e-01 | 0.732 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 9.144602e-02 | 1.039 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 9.144602e-02 | 1.039 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.257688e-01 | 0.900 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.160010e-01 | 0.666 |
| R-HSA-354192 | Integrin signaling | 2.210117e-01 | 0.656 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.358541e-01 | 0.627 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.358541e-01 | 0.627 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.792844e-01 | 0.746 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.792844e-01 | 0.746 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.587326e-01 | 0.799 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.007768e-01 | 0.697 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 8.565959e-02 | 1.067 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.210117e-01 | 0.656 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.210117e-01 | 0.656 |
| R-HSA-425381 | Bicarbonate transporters | 8.569172e-02 | 1.067 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.030857e-01 | 0.987 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.144992e-01 | 0.941 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.094491e-01 | 0.961 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.815707e-01 | 0.741 |
| R-HSA-9659379 | Sensory processing of sound | 1.074044e-01 | 0.969 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.000094e-01 | 0.699 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.210117e-01 | 0.656 |
| R-HSA-194138 | Signaling by VEGF | 2.256962e-01 | 0.646 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.259906e-01 | 0.646 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.309380e-01 | 0.637 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.309380e-01 | 0.637 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.358541e-01 | 0.627 |
| R-HSA-169911 | Regulation of Apoptosis | 2.358541e-01 | 0.627 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.904650e-01 | 0.720 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.177995e-01 | 0.929 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.656942e-01 | 0.781 |
| R-HSA-199991 | Membrane Trafficking | 1.373774e-01 | 0.862 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.390703e-01 | 0.857 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.198240e-01 | 0.921 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.608450e-02 | 1.017 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.313503e-01 | 0.882 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.641056e-01 | 0.785 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 1.694446e-01 | 0.771 |
| R-HSA-3295583 | TRP channels | 1.852598e-01 | 0.732 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.641056e-01 | 0.785 |
| R-HSA-69206 | G1/S Transition | 2.256962e-01 | 0.646 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.358541e-01 | 0.627 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.007768e-01 | 0.697 |
| R-HSA-3214842 | HDMs demethylate histones | 1.800215e-01 | 0.745 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 9.339990e-02 | 1.030 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.088105e-01 | 0.963 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.144992e-01 | 0.941 |
| R-HSA-210991 | Basigin interactions | 1.533254e-01 | 0.814 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 8.950452e-02 | 1.048 |
| R-HSA-9675108 | Nervous system development | 9.234224e-02 | 1.035 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.368965e-01 | 0.864 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.852598e-01 | 0.732 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 2.358541e-01 | 0.627 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.694446e-01 | 0.771 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.522517e-01 | 0.817 |
| R-HSA-373753 | Nephrin family interactions | 1.478838e-01 | 0.830 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.800215e-01 | 0.745 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.109584e-01 | 0.676 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.160010e-01 | 0.666 |
| R-HSA-5693538 | Homology Directed Repair | 2.069825e-01 | 0.684 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.641056e-01 | 0.785 |
| R-HSA-597592 | Post-translational protein modification | 1.845111e-01 | 0.734 |
| R-HSA-8983711 | OAS antiviral response | 9.732442e-02 | 1.012 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.679248e-01 | 0.775 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.309380e-01 | 0.637 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.792844e-01 | 0.746 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.703624e-01 | 0.769 |
| R-HSA-212436 | Generic Transcription Pathway | 1.286984e-01 | 0.890 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.312775e-01 | 0.882 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.976915e-01 | 0.704 |
| R-HSA-2028269 | Signaling by Hippo | 1.313503e-01 | 0.882 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.368965e-01 | 0.864 |
| R-HSA-418346 | Platelet homeostasis | 1.747257e-01 | 0.758 |
| R-HSA-5663205 | Infectious disease | 2.032641e-01 | 0.692 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.641056e-01 | 0.785 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.211629e-02 | 1.036 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.347354e-01 | 0.871 |
| R-HSA-168256 | Immune System | 1.710961e-01 | 0.767 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.542962e-02 | 1.068 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.407391e-01 | 0.618 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.407391e-01 | 0.618 |
| R-HSA-8853659 | RET signaling | 2.407391e-01 | 0.618 |
| R-HSA-5576891 | Cardiac conduction | 2.421738e-01 | 0.616 |
| R-HSA-4641258 | Degradation of DVL | 2.455931e-01 | 0.610 |
| R-HSA-4641257 | Degradation of AXIN | 2.455931e-01 | 0.610 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.455931e-01 | 0.610 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.455931e-01 | 0.610 |
| R-HSA-8875878 | MET promotes cell motility | 2.504165e-01 | 0.601 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.504165e-01 | 0.601 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.552092e-01 | 0.593 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.552092e-01 | 0.593 |
| R-HSA-69541 | Stabilization of p53 | 2.552092e-01 | 0.593 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.592721e-01 | 0.586 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.599717e-01 | 0.585 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.599717e-01 | 0.585 |
| R-HSA-6807070 | PTEN Regulation | 2.634347e-01 | 0.579 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.647039e-01 | 0.577 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.647039e-01 | 0.577 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.647039e-01 | 0.577 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.647039e-01 | 0.577 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.647039e-01 | 0.577 |
| R-HSA-9694548 | Maturation of spike protein | 2.647039e-01 | 0.577 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.647039e-01 | 0.577 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.694062e-01 | 0.570 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.694062e-01 | 0.570 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.694062e-01 | 0.570 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.694062e-01 | 0.570 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.694062e-01 | 0.570 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.752575e-01 | 0.560 |
| R-HSA-1461973 | Defensins | 2.787217e-01 | 0.555 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.787217e-01 | 0.555 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.787217e-01 | 0.555 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.803489e-01 | 0.552 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.823484e-01 | 0.549 |
| R-HSA-373752 | Netrin-1 signaling | 2.833352e-01 | 0.548 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.833352e-01 | 0.548 |
| R-HSA-9907900 | Proteasome assembly | 2.833352e-01 | 0.548 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.847110e-01 | 0.546 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.879195e-01 | 0.541 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.879195e-01 | 0.541 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.879195e-01 | 0.541 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.879195e-01 | 0.541 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.879195e-01 | 0.541 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.879195e-01 | 0.541 |
| R-HSA-9824272 | Somitogenesis | 2.879195e-01 | 0.541 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.924747e-01 | 0.534 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.924747e-01 | 0.534 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.924747e-01 | 0.534 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 2.965127e-01 | 0.528 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.970011e-01 | 0.527 |
| R-HSA-446728 | Cell junction organization | 2.976817e-01 | 0.526 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.988701e-01 | 0.525 |
| R-HSA-69306 | DNA Replication | 2.988701e-01 | 0.525 |
| R-HSA-73887 | Death Receptor Signaling | 3.012264e-01 | 0.521 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.014988e-01 | 0.521 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.014988e-01 | 0.521 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.059680e-01 | 0.514 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.059680e-01 | 0.514 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.059680e-01 | 0.514 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.104089e-01 | 0.508 |
| R-HSA-109704 | PI3K Cascade | 3.104089e-01 | 0.508 |
| R-HSA-9864848 | Complex IV assembly | 3.148217e-01 | 0.502 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.148217e-01 | 0.502 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.148217e-01 | 0.502 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.148217e-01 | 0.502 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.153352e-01 | 0.501 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.168828e-01 | 0.499 |
| R-HSA-72187 | mRNA 3'-end processing | 3.192065e-01 | 0.496 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.192065e-01 | 0.496 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.192065e-01 | 0.496 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.235635e-01 | 0.490 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.235635e-01 | 0.490 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.278928e-01 | 0.484 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.291204e-01 | 0.483 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.321948e-01 | 0.479 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.364694e-01 | 0.473 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.364694e-01 | 0.473 |
| R-HSA-75893 | TNF signaling | 3.364694e-01 | 0.473 |
| R-HSA-112399 | IRS-mediated signalling | 3.407170e-01 | 0.468 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.407170e-01 | 0.468 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.449377e-01 | 0.462 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.479920e-01 | 0.458 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.479920e-01 | 0.458 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.491315e-01 | 0.457 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 3.491315e-01 | 0.457 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.532988e-01 | 0.452 |
| R-HSA-351202 | Metabolism of polyamines | 3.532988e-01 | 0.452 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.574397e-01 | 0.447 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.574397e-01 | 0.447 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.574397e-01 | 0.447 |
| R-HSA-450294 | MAP kinase activation | 3.574397e-01 | 0.447 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.574397e-01 | 0.447 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.615543e-01 | 0.442 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.656428e-01 | 0.437 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.697054e-01 | 0.432 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.697054e-01 | 0.432 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.737422e-01 | 0.427 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.737422e-01 | 0.427 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.737422e-01 | 0.427 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.817392e-01 | 0.418 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 3.817392e-01 | 0.418 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.856997e-01 | 0.414 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.892015e-01 | 0.410 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.935454e-01 | 0.405 |
| R-HSA-448424 | Interleukin-17 signaling | 3.935454e-01 | 0.405 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.935454e-01 | 0.405 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.935454e-01 | 0.405 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.974310e-01 | 0.401 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.004540e-01 | 0.397 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.012920e-01 | 0.397 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.012920e-01 | 0.397 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.051284e-01 | 0.392 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.051284e-01 | 0.392 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.089405e-01 | 0.388 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.089405e-01 | 0.388 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.089405e-01 | 0.388 |
| R-HSA-8852135 | Protein ubiquitination | 4.127283e-01 | 0.384 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.127283e-01 | 0.384 |
| R-HSA-917937 | Iron uptake and transport | 4.127283e-01 | 0.384 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.138305e-01 | 0.383 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.160459e-01 | 0.381 |
| R-HSA-5689603 | UCH proteinases | 4.164922e-01 | 0.380 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.175544e-01 | 0.379 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.202321e-01 | 0.377 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.239484e-01 | 0.373 |
| R-HSA-5619084 | ABC transporter disorders | 4.239484e-01 | 0.373 |
| R-HSA-4086400 | PCP/CE pathway | 4.239484e-01 | 0.373 |
| R-HSA-6806834 | Signaling by MET | 4.313102e-01 | 0.365 |
| R-HSA-9833482 | PKR-mediated signaling | 4.313102e-01 | 0.365 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.349561e-01 | 0.362 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.349561e-01 | 0.362 |
| R-HSA-397014 | Muscle contraction | 4.379682e-01 | 0.359 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.421785e-01 | 0.354 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.421785e-01 | 0.354 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.457554e-01 | 0.351 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.457554e-01 | 0.351 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.493096e-01 | 0.347 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.493096e-01 | 0.347 |
| R-HSA-418990 | Adherens junctions interactions | 4.509098e-01 | 0.346 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.528412e-01 | 0.344 |
| R-HSA-8951664 | Neddylation | 4.573184e-01 | 0.340 |
| R-HSA-382551 | Transport of small molecules | 4.611806e-01 | 0.336 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.633019e-01 | 0.334 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.667447e-01 | 0.331 |
| R-HSA-73884 | Base Excision Repair | 4.701655e-01 | 0.328 |
| R-HSA-202424 | Downstream TCR signaling | 4.701655e-01 | 0.328 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.769421e-01 | 0.322 |
| R-HSA-74752 | Signaling by Insulin receptor | 4.802982e-01 | 0.318 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.802982e-01 | 0.318 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.836329e-01 | 0.315 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.902389e-01 | 0.310 |
| R-HSA-8939211 | ESR-mediated signaling | 4.907633e-01 | 0.309 |
| R-HSA-392499 | Metabolism of proteins | 4.918335e-01 | 0.308 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.935105e-01 | 0.307 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 4.967613e-01 | 0.304 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 4.967613e-01 | 0.304 |
| R-HSA-157118 | Signaling by NOTCH | 4.968918e-01 | 0.304 |
| R-HSA-168249 | Innate Immune System | 4.991704e-01 | 0.302 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.999914e-01 | 0.301 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.032009e-01 | 0.298 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.032009e-01 | 0.298 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.032009e-01 | 0.298 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.063901e-01 | 0.296 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.095590e-01 | 0.293 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.095590e-01 | 0.293 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.127077e-01 | 0.290 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.127077e-01 | 0.290 |
| R-HSA-1483255 | PI Metabolism | 5.158364e-01 | 0.287 |
| R-HSA-421270 | Cell-cell junction organization | 5.189631e-01 | 0.285 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.220343e-01 | 0.282 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.220343e-01 | 0.282 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.281536e-01 | 0.277 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.281536e-01 | 0.277 |
| R-HSA-69239 | Synthesis of DNA | 5.341953e-01 | 0.272 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.341953e-01 | 0.272 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.341953e-01 | 0.272 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.371874e-01 | 0.270 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.371874e-01 | 0.270 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.401604e-01 | 0.267 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.412567e-01 | 0.267 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.423068e-01 | 0.266 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.431145e-01 | 0.265 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.431145e-01 | 0.265 |
| R-HSA-202403 | TCR signaling | 5.431145e-01 | 0.265 |
| R-HSA-6803157 | Antimicrobial peptides | 5.460499e-01 | 0.263 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.518027e-01 | 0.258 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.518646e-01 | 0.258 |
| R-HSA-72766 | Translation | 5.519112e-01 | 0.258 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.547442e-01 | 0.256 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.547442e-01 | 0.256 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.604487e-01 | 0.251 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.630163e-01 | 0.249 |
| R-HSA-373760 | L1CAM interactions | 5.660807e-01 | 0.247 |
| R-HSA-1643685 | Disease | 5.665579e-01 | 0.247 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.688699e-01 | 0.245 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.743950e-01 | 0.241 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.743950e-01 | 0.241 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.743950e-01 | 0.241 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.798501e-01 | 0.237 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.813421e-01 | 0.236 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.825516e-01 | 0.235 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.825516e-01 | 0.235 |
| R-HSA-109582 | Hemostasis | 5.902812e-01 | 0.229 |
| R-HSA-114608 | Platelet degranulation | 5.984031e-01 | 0.223 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.006896e-01 | 0.221 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.009864e-01 | 0.221 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 6.111562e-01 | 0.214 |
| R-HSA-1266738 | Developmental Biology | 6.150211e-01 | 0.211 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.161444e-01 | 0.210 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.259315e-01 | 0.203 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.259315e-01 | 0.203 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.307320e-01 | 0.200 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.307320e-01 | 0.200 |
| R-HSA-9664407 | Parasite infection | 6.354714e-01 | 0.197 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.354714e-01 | 0.197 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.354714e-01 | 0.197 |
| R-HSA-1632852 | Macroautophagy | 6.378185e-01 | 0.195 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.378185e-01 | 0.195 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.470581e-01 | 0.189 |
| R-HSA-69242 | S Phase | 6.560643e-01 | 0.183 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.560643e-01 | 0.183 |
| R-HSA-166520 | Signaling by NTRKs | 6.560643e-01 | 0.183 |
| R-HSA-9758941 | Gastrulation | 6.582800e-01 | 0.182 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.626692e-01 | 0.179 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.648428e-01 | 0.177 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.691484e-01 | 0.174 |
| R-HSA-1989781 | PPARA activates gene expression | 6.712807e-01 | 0.173 |
| R-HSA-9612973 | Autophagy | 6.733993e-01 | 0.172 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.755044e-01 | 0.170 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 6.755044e-01 | 0.170 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.761127e-01 | 0.170 |
| R-HSA-9711097 | Cellular response to starvation | 6.775961e-01 | 0.169 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.775961e-01 | 0.169 |
| R-HSA-877300 | Interferon gamma signaling | 6.796744e-01 | 0.168 |
| R-HSA-73894 | DNA Repair | 7.018106e-01 | 0.154 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.055153e-01 | 0.151 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.059273e-01 | 0.151 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.074153e-01 | 0.150 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.093031e-01 | 0.149 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.111790e-01 | 0.148 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.130428e-01 | 0.147 |
| R-HSA-611105 | Respiratory electron transport | 7.185631e-01 | 0.144 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.275308e-01 | 0.138 |
| R-HSA-69275 | G2/M Transition | 7.327750e-01 | 0.135 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.362155e-01 | 0.133 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.505703e-01 | 0.125 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.559562e-01 | 0.122 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.093115e-01 | 0.092 |
| R-HSA-1280218 | Adaptive Immune System | 8.198601e-01 | 0.086 |
| R-HSA-112316 | Neuronal System | 8.236136e-01 | 0.084 |
| R-HSA-5688426 | Deubiquitination | 8.303778e-01 | 0.081 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.314781e-01 | 0.080 |
| R-HSA-9658195 | Leishmania infection | 8.568003e-01 | 0.067 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.568003e-01 | 0.067 |
| R-HSA-1483257 | Phospholipid metabolism | 8.692946e-01 | 0.061 |
| R-HSA-195721 | Signaling by WNT | 8.718281e-01 | 0.060 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.889792e-01 | 0.051 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.911345e-01 | 0.050 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.032233e-01 | 0.044 |
| R-HSA-449147 | Signaling by Interleukins | 9.218086e-01 | 0.035 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.302627e-01 | 0.031 |
| R-HSA-6798695 | Neutrophil degranulation | 9.551190e-01 | 0.020 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.845563e-01 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 9.945650e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.968954e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.977643e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.995377e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.998996e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GRK1 |
0.810 | 0.306 | -2 | 0.739 |
COT |
0.808 | 0.257 | 2 | 0.767 |
CLK3 |
0.804 | 0.208 | 1 | 0.756 |
BMPR1B |
0.802 | 0.328 | 1 | 0.838 |
MOS |
0.799 | 0.276 | 1 | 0.811 |
CDC7 |
0.796 | 0.167 | 1 | 0.819 |
GRK7 |
0.793 | 0.262 | 1 | 0.723 |
KIS |
0.792 | 0.114 | 1 | 0.578 |
FAM20C |
0.791 | 0.182 | 2 | 0.651 |
IKKB |
0.788 | 0.079 | -2 | 0.637 |
IKKA |
0.788 | 0.149 | -2 | 0.639 |
PIM3 |
0.787 | 0.094 | -3 | 0.709 |
BMPR1A |
0.784 | 0.263 | 1 | 0.813 |
GRK6 |
0.784 | 0.195 | 1 | 0.788 |
DSTYK |
0.783 | 0.092 | 2 | 0.800 |
MTOR |
0.781 | 0.025 | 1 | 0.660 |
GRK5 |
0.779 | 0.081 | -3 | 0.790 |
CAMK2G |
0.779 | 0.038 | 2 | 0.740 |
CK2A2 |
0.779 | 0.232 | 1 | 0.756 |
PRPK |
0.779 | -0.026 | -1 | 0.760 |
ATR |
0.778 | 0.064 | 1 | 0.740 |
TGFBR1 |
0.776 | 0.161 | -2 | 0.704 |
ACVR2B |
0.776 | 0.198 | -2 | 0.685 |
RAF1 |
0.775 | -0.008 | 1 | 0.735 |
NDR2 |
0.775 | 0.017 | -3 | 0.699 |
GRK4 |
0.775 | 0.096 | -2 | 0.736 |
ERK5 |
0.775 | 0.089 | 1 | 0.765 |
CK1E |
0.774 | 0.171 | -3 | 0.645 |
CK2A1 |
0.773 | 0.228 | 1 | 0.741 |
ACVR2A |
0.772 | 0.167 | -2 | 0.672 |
CHAK2 |
0.772 | 0.063 | -1 | 0.718 |
SKMLCK |
0.772 | 0.042 | -2 | 0.724 |
CDK1 |
0.771 | 0.083 | 1 | 0.552 |
ALK2 |
0.771 | 0.165 | -2 | 0.711 |
BMPR2 |
0.770 | -0.048 | -2 | 0.754 |
CDKL1 |
0.770 | 0.057 | -3 | 0.685 |
GRK2 |
0.769 | 0.132 | -2 | 0.633 |
CK1D |
0.769 | 0.169 | -3 | 0.602 |
MLK1 |
0.769 | 0.017 | 2 | 0.688 |
CAMK2B |
0.768 | 0.079 | 2 | 0.748 |
PIM1 |
0.768 | 0.040 | -3 | 0.660 |
CLK2 |
0.767 | 0.097 | -3 | 0.632 |
GRK3 |
0.767 | 0.149 | -2 | 0.605 |
ALK4 |
0.767 | 0.095 | -2 | 0.729 |
GCN2 |
0.766 | -0.144 | 2 | 0.671 |
TBK1 |
0.766 | -0.070 | 1 | 0.593 |
PDHK4 |
0.766 | -0.210 | 1 | 0.730 |
PASK |
0.766 | 0.208 | -3 | 0.733 |
CDK8 |
0.766 | 0.055 | 1 | 0.552 |
CDKL5 |
0.766 | 0.092 | -3 | 0.672 |
HIPK4 |
0.766 | 0.059 | 1 | 0.668 |
CAMK1B |
0.764 | -0.082 | -3 | 0.738 |
P38B |
0.764 | 0.117 | 1 | 0.557 |
SRPK1 |
0.764 | 0.012 | -3 | 0.644 |
CAMK2A |
0.763 | 0.058 | 2 | 0.766 |
IKKE |
0.763 | -0.090 | 1 | 0.585 |
JNK3 |
0.763 | 0.062 | 1 | 0.541 |
DLK |
0.763 | 0.010 | 1 | 0.740 |
GSK3A |
0.763 | 0.159 | 4 | 0.579 |
RSK2 |
0.763 | -0.012 | -3 | 0.644 |
ATM |
0.763 | 0.029 | 1 | 0.687 |
ICK |
0.762 | 0.089 | -3 | 0.714 |
JNK2 |
0.762 | 0.070 | 1 | 0.509 |
NLK |
0.761 | -0.082 | 1 | 0.703 |
CDK19 |
0.761 | 0.057 | 1 | 0.520 |
P38D |
0.760 | 0.096 | 1 | 0.468 |
MAPKAPK2 |
0.760 | 0.010 | -3 | 0.585 |
MLK3 |
0.759 | 0.030 | 2 | 0.619 |
CK1A2 |
0.759 | 0.142 | -3 | 0.603 |
LATS1 |
0.759 | 0.060 | -3 | 0.706 |
PRKD1 |
0.759 | -0.027 | -3 | 0.674 |
DYRK2 |
0.758 | 0.033 | 1 | 0.596 |
NEK6 |
0.757 | -0.090 | -2 | 0.713 |
MLK4 |
0.757 | 0.055 | 2 | 0.591 |
TLK2 |
0.756 | 0.038 | 1 | 0.681 |
ERK1 |
0.756 | 0.071 | 1 | 0.533 |
CAMK2D |
0.755 | -0.068 | -3 | 0.686 |
RIPK3 |
0.755 | -0.110 | 3 | 0.652 |
TGFBR2 |
0.755 | -0.094 | -2 | 0.676 |
P38A |
0.754 | 0.083 | 1 | 0.616 |
NIK |
0.754 | -0.175 | -3 | 0.745 |
CK1G1 |
0.754 | 0.087 | -3 | 0.637 |
DAPK2 |
0.754 | -0.088 | -3 | 0.733 |
NEK7 |
0.753 | -0.166 | -3 | 0.701 |
CAMLCK |
0.753 | -0.102 | -2 | 0.699 |
LATS2 |
0.753 | -0.049 | -5 | 0.668 |
PKN3 |
0.753 | -0.094 | -3 | 0.685 |
ULK2 |
0.753 | -0.243 | 2 | 0.625 |
PDHK1 |
0.752 | -0.297 | 1 | 0.705 |
MST4 |
0.752 | -0.102 | 2 | 0.753 |
GSK3B |
0.752 | 0.106 | 4 | 0.570 |
NDR1 |
0.752 | -0.116 | -3 | 0.684 |
P38G |
0.752 | 0.040 | 1 | 0.461 |
RSK4 |
0.752 | 0.004 | -3 | 0.612 |
HIPK2 |
0.751 | 0.050 | 1 | 0.507 |
PLK1 |
0.751 | -0.009 | -2 | 0.652 |
CDK18 |
0.751 | 0.030 | 1 | 0.516 |
DNAPK |
0.751 | 0.022 | 1 | 0.577 |
JNK1 |
0.750 | 0.058 | 1 | 0.510 |
PLK2 |
0.750 | 0.126 | -3 | 0.762 |
MLK2 |
0.750 | -0.095 | 2 | 0.687 |
P90RSK |
0.750 | -0.064 | -3 | 0.644 |
CK1A |
0.750 | 0.167 | -3 | 0.536 |
MASTL |
0.750 | -0.237 | -2 | 0.701 |
MEK1 |
0.750 | -0.064 | 2 | 0.723 |
HUNK |
0.749 | -0.159 | 2 | 0.680 |
CDK3 |
0.749 | 0.043 | 1 | 0.492 |
PLK3 |
0.749 | -0.002 | 2 | 0.688 |
CDK5 |
0.748 | 0.016 | 1 | 0.596 |
PRKX |
0.748 | 0.003 | -3 | 0.547 |
DYRK4 |
0.748 | 0.043 | 1 | 0.527 |
WNK1 |
0.748 | -0.168 | -2 | 0.760 |
PRKD2 |
0.748 | -0.062 | -3 | 0.624 |
YSK4 |
0.748 | -0.085 | 1 | 0.658 |
NUAK2 |
0.747 | -0.113 | -3 | 0.709 |
GAK |
0.747 | 0.169 | 1 | 0.797 |
SRPK2 |
0.747 | -0.024 | -3 | 0.563 |
MARK4 |
0.747 | -0.140 | 4 | 0.723 |
SRPK3 |
0.746 | -0.025 | -3 | 0.621 |
TTBK2 |
0.746 | -0.148 | 2 | 0.548 |
MEKK3 |
0.745 | -0.010 | 1 | 0.702 |
PKR |
0.745 | -0.093 | 1 | 0.745 |
SMG1 |
0.745 | -0.069 | 1 | 0.689 |
ANKRD3 |
0.744 | -0.206 | 1 | 0.739 |
MPSK1 |
0.744 | 0.121 | 1 | 0.712 |
PKN2 |
0.744 | -0.136 | -3 | 0.691 |
BCKDK |
0.744 | -0.226 | -1 | 0.668 |
ULK1 |
0.744 | -0.228 | -3 | 0.690 |
DRAK1 |
0.744 | 0.026 | 1 | 0.754 |
AURC |
0.743 | -0.060 | -2 | 0.487 |
MSK1 |
0.743 | -0.034 | -3 | 0.610 |
P70S6KB |
0.743 | -0.108 | -3 | 0.654 |
CDK7 |
0.743 | -0.035 | 1 | 0.570 |
PKCD |
0.743 | -0.102 | 2 | 0.649 |
CLK4 |
0.742 | -0.042 | -3 | 0.645 |
PKACB |
0.742 | -0.037 | -2 | 0.494 |
CDK17 |
0.742 | 0.001 | 1 | 0.470 |
PKACG |
0.742 | -0.115 | -2 | 0.565 |
MAPKAPK3 |
0.742 | -0.113 | -3 | 0.615 |
RSK3 |
0.742 | -0.105 | -3 | 0.636 |
CDK13 |
0.742 | -0.043 | 1 | 0.537 |
TSSK2 |
0.741 | -0.119 | -5 | 0.705 |
PAK1 |
0.741 | -0.101 | -2 | 0.660 |
PRP4 |
0.741 | -0.005 | -3 | 0.654 |
CDK2 |
0.740 | -0.030 | 1 | 0.632 |
VRK2 |
0.740 | -0.235 | 1 | 0.755 |
HIPK1 |
0.740 | -0.008 | 1 | 0.609 |
AURA |
0.739 | -0.042 | -2 | 0.462 |
AMPKA1 |
0.739 | -0.175 | -3 | 0.707 |
BRAF |
0.739 | -0.062 | -4 | 0.682 |
ERK2 |
0.738 | -0.016 | 1 | 0.562 |
MSK2 |
0.738 | -0.093 | -3 | 0.617 |
IRE1 |
0.738 | -0.157 | 1 | 0.703 |
NEK9 |
0.737 | -0.270 | 2 | 0.684 |
RIPK1 |
0.737 | -0.263 | 1 | 0.700 |
MAK |
0.736 | 0.157 | -2 | 0.788 |
TAO3 |
0.735 | -0.024 | 1 | 0.685 |
MEKK2 |
0.735 | -0.063 | 2 | 0.655 |
PKCB |
0.735 | -0.103 | 2 | 0.606 |
WNK3 |
0.734 | -0.344 | 1 | 0.686 |
MYLK4 |
0.734 | -0.091 | -2 | 0.612 |
MST3 |
0.734 | -0.053 | 2 | 0.731 |
TLK1 |
0.734 | -0.089 | -2 | 0.716 |
CDK16 |
0.732 | 0.003 | 1 | 0.483 |
CLK1 |
0.732 | -0.060 | -3 | 0.618 |
TSSK1 |
0.732 | -0.141 | -3 | 0.728 |
IRE2 |
0.732 | -0.135 | 2 | 0.589 |
DYRK1A |
0.732 | -0.000 | 1 | 0.608 |
AMPKA2 |
0.731 | -0.166 | -3 | 0.668 |
CDK12 |
0.730 | -0.055 | 1 | 0.506 |
PIM2 |
0.730 | -0.058 | -3 | 0.613 |
PKCG |
0.730 | -0.134 | 2 | 0.607 |
MST2 |
0.729 | -0.022 | 1 | 0.707 |
CHAK1 |
0.729 | -0.186 | 2 | 0.628 |
GCK |
0.729 | -0.006 | 1 | 0.702 |
AKT2 |
0.728 | -0.070 | -3 | 0.570 |
MEK5 |
0.728 | -0.247 | 2 | 0.689 |
PINK1 |
0.728 | -0.132 | 1 | 0.715 |
ZAK |
0.728 | -0.165 | 1 | 0.659 |
PKCA |
0.728 | -0.122 | 2 | 0.591 |
NIM1 |
0.728 | -0.221 | 3 | 0.687 |
TAK1 |
0.727 | -0.008 | 1 | 0.703 |
PAK3 |
0.727 | -0.186 | -2 | 0.647 |
CAMK4 |
0.727 | -0.228 | -3 | 0.673 |
PAK2 |
0.727 | -0.158 | -2 | 0.642 |
PERK |
0.727 | -0.203 | -2 | 0.714 |
QSK |
0.727 | -0.144 | 4 | 0.686 |
EEF2K |
0.726 | -0.022 | 3 | 0.779 |
CDK14 |
0.725 | -0.041 | 1 | 0.548 |
PKCZ |
0.725 | -0.160 | 2 | 0.631 |
CHK1 |
0.725 | -0.131 | -3 | 0.661 |
ERK7 |
0.724 | -0.009 | 2 | 0.465 |
MEKK1 |
0.724 | -0.211 | 1 | 0.679 |
MARK3 |
0.724 | -0.131 | 4 | 0.639 |
AURB |
0.724 | -0.114 | -2 | 0.482 |
PRKD3 |
0.724 | -0.132 | -3 | 0.612 |
CDK9 |
0.723 | -0.103 | 1 | 0.544 |
CAMKK1 |
0.723 | -0.155 | -2 | 0.613 |
PAK6 |
0.722 | -0.112 | -2 | 0.562 |
DYRK1B |
0.722 | -0.051 | 1 | 0.555 |
HIPK3 |
0.722 | -0.059 | 1 | 0.578 |
MARK2 |
0.722 | -0.146 | 4 | 0.607 |
MAP2K6_TYR |
0.721 | 0.270 | -1 | 0.795 |
BRSK1 |
0.721 | -0.159 | -3 | 0.640 |
NEK5 |
0.721 | -0.205 | 1 | 0.723 |
PDHK1_TYR |
0.721 | 0.289 | -1 | 0.809 |
PKCH |
0.721 | -0.172 | 2 | 0.574 |
DYRK3 |
0.721 | -0.054 | 1 | 0.606 |
DAPK1 |
0.720 | -0.036 | -3 | 0.657 |
CDK10 |
0.720 | -0.049 | 1 | 0.537 |
PDHK4_TYR |
0.719 | 0.208 | 2 | 0.802 |
PDHK3_TYR |
0.719 | 0.193 | 4 | 0.841 |
DAPK3 |
0.719 | -0.067 | -3 | 0.665 |
PLK4 |
0.719 | -0.204 | 2 | 0.481 |
SIK |
0.719 | -0.160 | -3 | 0.616 |
PKACA |
0.719 | -0.074 | -2 | 0.440 |
DCAMKL1 |
0.719 | -0.144 | -3 | 0.639 |
ALPHAK3 |
0.719 | 0.094 | -1 | 0.694 |
PKG2 |
0.719 | -0.134 | -2 | 0.495 |
SGK3 |
0.719 | -0.129 | -3 | 0.613 |
LKB1 |
0.718 | -0.137 | -3 | 0.669 |
CAMKK2 |
0.718 | -0.162 | -2 | 0.599 |
MNK1 |
0.718 | -0.176 | -2 | 0.611 |
MNK2 |
0.718 | -0.197 | -2 | 0.607 |
NEK2 |
0.718 | -0.286 | 2 | 0.668 |
QIK |
0.718 | -0.274 | -3 | 0.684 |
NUAK1 |
0.717 | -0.188 | -3 | 0.639 |
BMPR2_TYR |
0.717 | 0.181 | -1 | 0.797 |
NEK11 |
0.717 | -0.212 | 1 | 0.663 |
MINK |
0.716 | -0.111 | 1 | 0.672 |
TNIK |
0.715 | -0.078 | 3 | 0.804 |
SMMLCK |
0.715 | -0.151 | -3 | 0.682 |
HPK1 |
0.715 | -0.086 | 1 | 0.676 |
MOK |
0.715 | 0.047 | 1 | 0.656 |
MELK |
0.715 | -0.229 | -3 | 0.641 |
NEK8 |
0.715 | -0.204 | 2 | 0.674 |
CAMK1G |
0.715 | -0.161 | -3 | 0.622 |
CK1G2 |
0.715 | 0.139 | -3 | 0.570 |
TXK |
0.714 | 0.245 | 1 | 0.839 |
HRI |
0.714 | -0.314 | -2 | 0.720 |
MAP2K4_TYR |
0.714 | 0.135 | -1 | 0.777 |
MAPKAPK5 |
0.714 | -0.194 | -3 | 0.558 |
MARK1 |
0.714 | -0.183 | 4 | 0.658 |
PHKG1 |
0.713 | -0.235 | -3 | 0.674 |
YANK3 |
0.713 | -0.023 | 2 | 0.337 |
CK1G3 |
0.713 | 0.106 | -3 | 0.498 |
WNK4 |
0.712 | -0.263 | -2 | 0.766 |
PDK1 |
0.712 | -0.171 | 1 | 0.654 |
MST1 |
0.712 | -0.123 | 1 | 0.682 |
TAO2 |
0.711 | -0.202 | 2 | 0.711 |
OSR1 |
0.711 | -0.009 | 2 | 0.662 |
TTBK1 |
0.710 | -0.218 | 2 | 0.476 |
HGK |
0.710 | -0.144 | 3 | 0.792 |
BRSK2 |
0.710 | -0.245 | -3 | 0.655 |
MAP3K15 |
0.709 | -0.172 | 1 | 0.634 |
KHS2 |
0.709 | -0.061 | 1 | 0.671 |
CDK6 |
0.709 | -0.050 | 1 | 0.519 |
FYN |
0.707 | 0.208 | -1 | 0.746 |
BUB1 |
0.707 | -0.030 | -5 | 0.695 |
VRK1 |
0.707 | -0.190 | 2 | 0.689 |
SYK |
0.707 | 0.229 | -1 | 0.753 |
MEKK6 |
0.707 | -0.202 | 1 | 0.687 |
SNRK |
0.706 | -0.318 | 2 | 0.538 |
KHS1 |
0.706 | -0.101 | 1 | 0.651 |
AKT1 |
0.706 | -0.114 | -3 | 0.570 |
CAMK1D |
0.706 | -0.124 | -3 | 0.543 |
P70S6K |
0.706 | -0.150 | -3 | 0.561 |
PBK |
0.705 | -0.031 | 1 | 0.736 |
LRRK2 |
0.705 | -0.249 | 2 | 0.710 |
PTK2 |
0.705 | 0.198 | -1 | 0.745 |
DCAMKL2 |
0.705 | -0.191 | -3 | 0.663 |
SSTK |
0.705 | -0.193 | 4 | 0.674 |
SLK |
0.704 | -0.136 | -2 | 0.570 |
IRAK4 |
0.704 | -0.298 | 1 | 0.693 |
TTK |
0.704 | -0.044 | -2 | 0.686 |
EPHA4 |
0.703 | 0.090 | 2 | 0.713 |
PKCE |
0.703 | -0.130 | 2 | 0.590 |
BLK |
0.702 | 0.165 | -1 | 0.758 |
FGR |
0.702 | 0.102 | 1 | 0.816 |
EPHA6 |
0.702 | 0.068 | -1 | 0.771 |
EPHB4 |
0.701 | 0.080 | -1 | 0.725 |
TESK1_TYR |
0.701 | -0.124 | 3 | 0.810 |
CDK4 |
0.701 | -0.067 | 1 | 0.497 |
SGK1 |
0.700 | -0.080 | -3 | 0.490 |
NEK4 |
0.699 | -0.294 | 1 | 0.669 |
SRMS |
0.699 | 0.094 | 1 | 0.816 |
FER |
0.699 | 0.055 | 1 | 0.824 |
PKCT |
0.699 | -0.212 | 2 | 0.577 |
MAP2K7_TYR |
0.699 | -0.190 | 2 | 0.746 |
PAK5 |
0.699 | -0.157 | -2 | 0.502 |
LCK |
0.698 | 0.128 | -1 | 0.757 |
AKT3 |
0.698 | -0.088 | -3 | 0.510 |
YES1 |
0.698 | 0.065 | -1 | 0.729 |
SBK |
0.697 | -0.069 | -3 | 0.458 |
ABL2 |
0.697 | 0.085 | -1 | 0.693 |
PKCI |
0.697 | -0.203 | 2 | 0.601 |
PKMYT1_TYR |
0.697 | -0.135 | 3 | 0.776 |
NEK1 |
0.697 | -0.277 | 1 | 0.686 |
PINK1_TYR |
0.696 | -0.120 | 1 | 0.738 |
STK33 |
0.696 | -0.215 | 2 | 0.486 |
ROCK2 |
0.696 | -0.121 | -3 | 0.636 |
PAK4 |
0.696 | -0.146 | -2 | 0.502 |
IRAK1 |
0.694 | -0.383 | -1 | 0.612 |
MEK2 |
0.694 | -0.300 | 2 | 0.665 |
ITK |
0.694 | 0.075 | -1 | 0.691 |
EPHB2 |
0.693 | 0.072 | -1 | 0.710 |
LOK |
0.693 | -0.233 | -2 | 0.600 |
BIKE |
0.693 | 0.000 | 1 | 0.702 |
HCK |
0.692 | 0.032 | -1 | 0.742 |
EPHB1 |
0.692 | 0.039 | 1 | 0.800 |
CHK2 |
0.692 | -0.124 | -3 | 0.511 |
MRCKA |
0.692 | -0.145 | -3 | 0.602 |
YSK1 |
0.691 | -0.219 | 2 | 0.666 |
ABL1 |
0.691 | 0.039 | -1 | 0.679 |
BMX |
0.691 | 0.056 | -1 | 0.613 |
INSRR |
0.690 | 0.006 | 3 | 0.635 |
EPHB3 |
0.690 | 0.033 | -1 | 0.716 |
DMPK1 |
0.690 | -0.099 | -3 | 0.629 |
HASPIN |
0.690 | -0.095 | -1 | 0.532 |
MRCKB |
0.689 | -0.145 | -3 | 0.594 |
YANK2 |
0.688 | -0.021 | 2 | 0.349 |
SRC |
0.688 | 0.085 | -1 | 0.720 |
PHKG2 |
0.688 | -0.264 | -3 | 0.654 |
CSF1R |
0.687 | -0.041 | 3 | 0.689 |
ASK1 |
0.687 | -0.204 | 1 | 0.618 |
MYO3A |
0.686 | -0.141 | 1 | 0.655 |
FLT1 |
0.686 | 0.018 | -1 | 0.767 |
KIT |
0.686 | -0.030 | 3 | 0.697 |
LIMK2_TYR |
0.685 | -0.173 | -3 | 0.736 |
MYO3B |
0.685 | -0.151 | 2 | 0.692 |
EPHA5 |
0.685 | 0.059 | 2 | 0.693 |
LYN |
0.685 | 0.041 | 3 | 0.624 |
MET |
0.685 | 0.011 | 3 | 0.678 |
EPHA8 |
0.684 | 0.068 | -1 | 0.726 |
RET |
0.683 | -0.187 | 1 | 0.674 |
PKN1 |
0.683 | -0.183 | -3 | 0.579 |
CAMK1A |
0.683 | -0.152 | -3 | 0.526 |
EPHA7 |
0.682 | 0.005 | 2 | 0.687 |
TYRO3 |
0.681 | -0.158 | 3 | 0.689 |
RIPK2 |
0.681 | -0.369 | 1 | 0.609 |
JAK3 |
0.681 | -0.098 | 1 | 0.661 |
CRIK |
0.680 | -0.114 | -3 | 0.575 |
JAK2 |
0.680 | -0.172 | 1 | 0.654 |
EPHA3 |
0.680 | -0.052 | 2 | 0.666 |
EGFR |
0.680 | 0.010 | 1 | 0.586 |
TEC |
0.680 | -0.026 | -1 | 0.597 |
CSK |
0.679 | 0.020 | 2 | 0.683 |
ROS1 |
0.679 | -0.158 | 3 | 0.656 |
FRK |
0.679 | 0.012 | -1 | 0.753 |
ERBB4 |
0.679 | 0.069 | 1 | 0.640 |
MERTK |
0.679 | -0.035 | 3 | 0.674 |
ZAP70 |
0.679 | 0.104 | -1 | 0.656 |
TYK2 |
0.678 | -0.262 | 1 | 0.666 |
DDR1 |
0.678 | -0.222 | 4 | 0.740 |
MST1R |
0.678 | -0.231 | 3 | 0.708 |
ERBB2 |
0.678 | -0.067 | 1 | 0.666 |
AAK1 |
0.677 | 0.039 | 1 | 0.620 |
TNK2 |
0.677 | -0.099 | 3 | 0.654 |
FGFR4 |
0.676 | 0.008 | -1 | 0.673 |
FGFR2 |
0.675 | -0.148 | 3 | 0.699 |
STLK3 |
0.675 | -0.202 | 1 | 0.626 |
LIMK1_TYR |
0.675 | -0.341 | 2 | 0.712 |
PTK2B |
0.675 | -0.007 | -1 | 0.634 |
MATK |
0.674 | -0.038 | -1 | 0.623 |
ROCK1 |
0.673 | -0.161 | -3 | 0.599 |
EPHA2 |
0.673 | 0.034 | -1 | 0.692 |
KDR |
0.673 | -0.126 | 3 | 0.651 |
BTK |
0.672 | -0.128 | -1 | 0.636 |
FLT3 |
0.672 | -0.143 | 3 | 0.690 |
FGFR3 |
0.672 | -0.088 | 3 | 0.667 |
NTRK1 |
0.672 | -0.128 | -1 | 0.699 |
NTRK3 |
0.672 | -0.061 | -1 | 0.670 |
PTK6 |
0.671 | -0.146 | -1 | 0.612 |
PDGFRB |
0.668 | -0.227 | 3 | 0.693 |
TAO1 |
0.667 | -0.249 | 1 | 0.585 |
AXL |
0.666 | -0.180 | 3 | 0.662 |
NEK3 |
0.666 | -0.368 | 1 | 0.616 |
INSR |
0.665 | -0.128 | 3 | 0.619 |
TEK |
0.664 | -0.218 | 3 | 0.628 |
LTK |
0.664 | -0.160 | 3 | 0.634 |
WEE1_TYR |
0.664 | -0.155 | -1 | 0.620 |
PKG1 |
0.663 | -0.193 | -2 | 0.411 |
JAK1 |
0.663 | -0.177 | 1 | 0.596 |
FGFR1 |
0.663 | -0.223 | 3 | 0.650 |
TNNI3K_TYR |
0.663 | -0.160 | 1 | 0.701 |
FLT4 |
0.663 | -0.168 | 3 | 0.662 |
ALK |
0.661 | -0.186 | 3 | 0.596 |
IGF1R |
0.661 | -0.055 | 3 | 0.560 |
NEK10_TYR |
0.660 | -0.234 | 1 | 0.525 |
NTRK2 |
0.657 | -0.220 | 3 | 0.632 |
DDR2 |
0.657 | -0.122 | 3 | 0.624 |
EPHA1 |
0.657 | -0.173 | 3 | 0.657 |
PDGFRA |
0.655 | -0.323 | 3 | 0.694 |
TNK1 |
0.653 | -0.276 | 3 | 0.682 |
FES |
0.649 | -0.074 | -1 | 0.585 |
MUSK |
0.638 | -0.196 | 1 | 0.586 |