Motif 464 (n=178)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| K7EQG2 | None | S49 | ochoa | Uncharacterized protein | None |
| K7EQG2 | None | Y58 | ochoa | Uncharacterized protein | None |
| O00571 | DDX3X | S609 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14641 | DVL2 | S155 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14777 | NDC80 | S69 | ochoa|psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15075 | DCLK1 | S352 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15075 | DCLK1 | S355 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15085 | ARHGEF11 | S654 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O43399 | TPD52L2 | S152 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43566 | RGS14 | S39 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60271 | SPAG9 | S1241 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60716 | CTNND1 | S168 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75037 | KIF21B | S1272 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75381 | PEX14 | S265 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O94875 | SORBS2 | S248 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95155 | UBE4B | S90 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| P02545 | LMNA | S395 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S612 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S613 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S615 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S616 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S618 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S619 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02671 | FGA | S294 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P05783 | KRT18 | S47 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P07814 | EPRS1 | S816 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08183 | ABCB1 | S658 | ochoa | ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) | Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:35507548, ECO:0000269|PubMed:35970996, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}. |
| P08651 | NFIC | S276 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P08670 | VIM | S26 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08670 | VIM | S29 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P10070 | GLI2 | S823 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P15924 | DSP | S2597 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P17661 | DES | S45 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P22670 | RFX1 | S120 | ochoa|psp | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P25054 | APC | S1343 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27448 | MARK3 | S380 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P31943 | HNRNPH1 | S272 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P35568 | IRS1 | S1134 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35711 | SOX5 | S123 | ochoa | Transcription factor SOX-5 | Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}. |
| P38159 | RBMX | S280 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S326 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S328 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S329 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P43243 | MATR3 | S74 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P49321 | NASP | S689 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49321 | NASP | S692 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49790 | NUP153 | S188 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51114 | FXR1 | S406 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P51116 | FXR2 | T411 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51116 | FXR2 | S415 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51116 | FXR2 | S450 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P52594 | AGFG1 | S149 | ochoa | Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) | Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}. |
| P53667 | LIMK1 | S310 | ochoa|psp | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. |
| P55196 | AFDN | S1314 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55795 | HNRNPH2 | S272 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P57078 | RIPK4 | S423 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P61244 | MAX | S121 | ochoa | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| P82094 | TMF1 | S330 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q06587 | RING1 | S187 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
| Q07157 | TJP1 | S297 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S831 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07954 | LRP1 | S4520 | ochoa|psp | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371). {ECO:0000250|UniProtKB:Q91ZX7, ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:1702392, ECO:0000269|PubMed:26142438, ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:9252371}.; FUNCTION: (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. |
| Q08AD1 | CAMSAP2 | S1290 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q08AD1 | CAMSAP2 | S1304 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S5749 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5854 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5857 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12789 | GTF3C1 | S751 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q13131 | PRKAA1 | S520 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13263 | TRIM28 | S460 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13480 | GAB1 | S648 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13835 | PKP1 | S188 | ochoa|psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q13905 | RAPGEF1 | S352 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q13950 | RUNX2 | S240 | ochoa | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14161 | GIT2 | S559 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14684 | RRP1B | S341 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14739 | LBR | S73 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q14934 | NFATC4 | S278 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14980 | NUMA1 | S1847 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15032 | R3HDM1 | S383 | ochoa | R3H domain-containing protein 1 | None |
| Q15149 | PLEC | S4648 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S4651 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15555 | MAPRE2 | S219 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q15648 | MED1 | S1140 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q16512 | PKN1 | S575 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q2M1P5 | KIF7 | S455 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q4V328 | GRIPAP1 | S668 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q53GG5 | PDLIM3 | S136 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5T1M5 | FKBP15 | S1158 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5UIP0 | RIF1 | S1706 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT52 | RPRD2 | S596 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | S1134 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | S1137 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUA4 | ZNF318 | S1613 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWJ9 | SNX30 | S70 | ochoa | Sorting nexin-30 | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}. |
| Q6AI08 | HEATR6 | S388 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6P1L5 | FAM117B | S407 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P2E9 | EDC4 | S737 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P996 | PDXDC1 | S721 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PIJ6 | FBXO38 | S736 | ochoa | F-box only protein 38 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
| Q6R327 | RICTOR | S1588 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6XZF7 | DNMBP | S1362 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q7Z401 | DENND4A | S938 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z460 | CLASP1 | S555 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z460 | CLASP1 | S559 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z4S6 | KIF21A | S1307 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z5L9 | IRF2BP2 | S460 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z6L1 | TECPR1 | S409 | ochoa | Tectonin beta-propeller repeat-containing protein 1 | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
| Q86VP3 | PACS2 | S691 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86YS7 | C2CD5 | S304 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q8IY57 | YAF2 | S154 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8N1G2 | CMTR1 | S40 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N6H7 | ARFGAP2 | S337 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NC51 | SERBP1 | S202 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NC51 | SERBP1 | S205 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NEY8 | PPHLN1 | S150 | ochoa | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| Q8NHG8 | ZNRF2 | S116 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TD19 | NEK9 | S738 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8WWI1 | LMO7 | S1009 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWQ0 | PHIP | S1476 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q92597 | NDRG1 | S333 | ochoa | Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42) | Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}. |
| Q92609 | TBC1D5 | S557 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92997 | DVL3 | S567 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q92997 | DVL3 | S636 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q92997 | DVL3 | S639 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96E39 | RBMXL1 | S280 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S326 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S328 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S329 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96F45 | ZNF503 | S231 | ochoa | Zinc finger protein 503 | May function as a transcriptional repressor. {ECO:0000250}. |
| Q96J84 | KIRREL1 | S642 | ochoa | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}. |
| Q96PE1 | ADGRA2 | S963 | ochoa | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}. |
| Q96S38 | RPS6KC1 | S664 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96SU4 | OSBPL9 | S329 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q99569 | PKP4 | Y224 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99683 | MAP3K5 | S1227 | ochoa | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q99704 | DOK1 | Y449 | ochoa|psp | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q9BQ89 | FAM110A | S252 | ochoa | Protein FAM110A | None |
| Q9BRK4 | LZTS2 | S276 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BWF3 | RBM4 | S334 | ochoa | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9BXF6 | RAB11FIP5 | S251 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXK1 | KLF16 | S102 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BZL6 | PRKD2 | S203 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9C0B5 | ZDHHC5 | S448 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S744 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S1677 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H1K0 | RBSN | S233 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H3Y8 | PPDPF | S28 | ochoa | Pancreatic progenitor cell differentiation and proliferation factor (Exocrine differentiation and proliferation factor) | Probable regulator of exocrine pancreas development. {ECO:0000250}. |
| Q9HCU4 | CELSR2 | S2665 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NWH9 | SLTM | S1002 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NYF8 | BCLAF1 | Y284 | ochoa|psp | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZB2 | FAM120A | S510 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P1T7 | MDFIC | S140 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Q9P1Y5 | CAMSAP3 | Y1045 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P2D0 | IBTK | S1018 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9UBC2 | EPS15L1 | S374 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UGV2 | NDRG3 | S338 | ochoa | Protein NDRG3 (N-myc downstream-regulated gene 3 protein) | None |
| Q9UH99 | SUN2 | S113 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UI08 | EVL | S245 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9ULU4 | ZMYND8 | S475 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UPQ0 | LIMCH1 | S204 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ35 | SRRM2 | S1143 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQE7 | SMC3 | S1086 | ochoa | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y261 | FOXA2 | S306 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y2H0 | DLGAP4 | S608 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2K5 | R3HDM2 | S348 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y2K5 | R3HDM2 | S351 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y2U5 | MAP3K2 | S314 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y446 | PKP3 | S305 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4H2 | IRS2 | S591 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y520 | PRRC2C | S782 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5P4 | CERT1 | S144 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y608 | LRRFIP2 | S323 | ochoa | Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}. |
| Q9Y6N7 | ROBO1 | S1606 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| P18615 | NELFE | S135 | Sugiyama | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P60174 | TPI1 | S195 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P36578 | RPL4 | S63 | Sugiyama | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| O95817 | BAG3 | S184 | Sugiyama | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 8.321320e-09 | 8.080 |
| R-HSA-75153 | Apoptotic execution phase | 1.204008e-07 | 6.919 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 5.831980e-05 | 4.234 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 2.195667e-04 | 3.658 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.829128e-04 | 3.548 |
| R-HSA-109581 | Apoptosis | 6.166863e-04 | 3.210 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 1.276364e-03 | 2.894 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 1.825583e-03 | 2.739 |
| R-HSA-74713 | IRS activation | 2.468095e-03 | 2.608 |
| R-HSA-5357801 | Programmed Cell Death | 2.497120e-03 | 2.603 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.878685e-03 | 2.541 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 3.201952e-03 | 2.495 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 4.936060e-03 | 2.307 |
| R-HSA-112412 | SOS-mediated signalling | 4.936060e-03 | 2.307 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 5.025068e-03 | 2.299 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.824443e-03 | 2.317 |
| R-HSA-9006335 | Signaling by Erythropoietin | 5.906310e-03 | 2.229 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 5.932560e-03 | 2.227 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.025600e-02 | 1.989 |
| R-HSA-201688 | WNT mediated activation of DVL | 7.012906e-03 | 2.154 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 8.175294e-03 | 2.087 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 9.417949e-03 | 2.026 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.206353e-03 | 2.142 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.031883e-02 | 1.986 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 9.837774e-03 | 2.007 |
| R-HSA-198203 | PI3K/AKT activation | 8.175294e-03 | 2.087 |
| R-HSA-74749 | Signal attenuation | 8.175294e-03 | 2.087 |
| R-HSA-8853659 | RET signaling | 1.031883e-02 | 1.986 |
| R-HSA-2586552 | Signaling by Leptin | 8.175294e-03 | 2.087 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.213709e-02 | 1.916 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.235429e-02 | 1.908 |
| R-HSA-68875 | Mitotic Prophase | 1.311538e-02 | 1.882 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.361017e-02 | 1.866 |
| R-HSA-6809371 | Formation of the cornified envelope | 1.470985e-02 | 1.832 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.622787e-02 | 1.790 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.515667e-02 | 1.819 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.677497e-02 | 1.775 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.846345e-02 | 1.734 |
| R-HSA-9664420 | Killing mechanisms | 1.846345e-02 | 1.734 |
| R-HSA-109704 | PI3K Cascade | 2.265976e-02 | 1.645 |
| R-HSA-2028269 | Signaling by Hippo | 2.204458e-02 | 1.657 |
| R-HSA-1221632 | Meiotic synapsis | 2.578431e-02 | 1.589 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.790361e-02 | 1.554 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.790361e-02 | 1.554 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.393413e-02 | 1.621 |
| R-HSA-68886 | M Phase | 2.466068e-02 | 1.608 |
| R-HSA-112399 | IRS-mediated signalling | 3.029164e-02 | 1.519 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.045539e-02 | 1.516 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.518635e-02 | 1.454 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.518635e-02 | 1.454 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 3.431171e-02 | 1.465 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 4.040089e-02 | 1.394 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.646739e-02 | 1.438 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.910891e-02 | 1.408 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.910891e-02 | 1.408 |
| R-HSA-68882 | Mitotic Anaphase | 3.650667e-02 | 1.438 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.713966e-02 | 1.430 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.656307e-02 | 1.437 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.046386e-02 | 1.393 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.123044e-02 | 1.385 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.123044e-02 | 1.385 |
| R-HSA-8865999 | MET activates PTPN11 | 5.024497e-02 | 1.299 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.917898e-02 | 1.101 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 7.917898e-02 | 1.101 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 8.862760e-02 | 1.052 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 8.862760e-02 | 1.052 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 9.797983e-02 | 1.009 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 9.797983e-02 | 1.009 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.072367e-01 | 0.970 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.072367e-01 | 0.970 |
| R-HSA-8875656 | MET receptor recycling | 1.072367e-01 | 0.970 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.163991e-01 | 0.934 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.254680e-01 | 0.901 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.254680e-01 | 0.901 |
| R-HSA-4839744 | Signaling by APC mutants | 1.344444e-01 | 0.871 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.344444e-01 | 0.871 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.344444e-01 | 0.871 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.344444e-01 | 0.871 |
| R-HSA-428540 | Activation of RAC1 | 1.433293e-01 | 0.844 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.433293e-01 | 0.844 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.521234e-01 | 0.818 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.521234e-01 | 0.818 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.521234e-01 | 0.818 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.521234e-01 | 0.818 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.521234e-01 | 0.818 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 5.118663e-02 | 1.291 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 5.915728e-02 | 1.228 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.779711e-01 | 0.750 |
| R-HSA-390522 | Striated Muscle Contraction | 6.469250e-02 | 1.189 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.864118e-01 | 0.730 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 6.752303e-02 | 1.171 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 7.039398e-02 | 1.152 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.030355e-01 | 0.692 |
| R-HSA-180292 | GAB1 signalosome | 2.112203e-01 | 0.675 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.193215e-01 | 0.659 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.193215e-01 | 0.659 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 9.468695e-02 | 1.024 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.273400e-01 | 0.643 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.352767e-01 | 0.628 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.431323e-01 | 0.614 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.431323e-01 | 0.614 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.509077e-01 | 0.600 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 2.737608e-01 | 0.563 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.886097e-01 | 0.540 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.886097e-01 | 0.540 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.959207e-01 | 0.529 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.959207e-01 | 0.529 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.959207e-01 | 0.529 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.031569e-01 | 0.518 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.103192e-01 | 0.508 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.174084e-01 | 0.498 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.174084e-01 | 0.498 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.887900e-01 | 0.724 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.313701e-01 | 0.480 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.313701e-01 | 0.480 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.382441e-01 | 0.471 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 2.262624e-01 | 0.645 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.528086e-01 | 0.597 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.528086e-01 | 0.597 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.642171e-01 | 0.578 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.977728e-02 | 1.303 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.787524e-01 | 0.748 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.862315e-02 | 1.313 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.450479e-01 | 0.462 |
| R-HSA-373753 | Nephrin family interactions | 2.273400e-01 | 0.643 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.254680e-01 | 0.901 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.344444e-01 | 0.871 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.864118e-01 | 0.730 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.509077e-01 | 0.600 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.405479e-02 | 1.130 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.248524e-01 | 0.488 |
| R-HSA-191650 | Regulation of gap junction activity | 5.998867e-02 | 1.222 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 7.917898e-02 | 1.101 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.509077e-01 | 0.600 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.076107e-01 | 0.968 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.076107e-01 | 0.968 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.076107e-01 | 0.968 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.103192e-01 | 0.508 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.779711e-01 | 0.750 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 7.625273e-02 | 1.118 |
| R-HSA-5674135 | MAP2K and MAPK activation | 9.153122e-02 | 1.038 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.972518e-01 | 0.705 |
| R-HSA-354192 | Integrin signaling | 3.313701e-01 | 0.480 |
| R-HSA-72172 | mRNA Splicing | 2.015188e-01 | 0.696 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.103192e-01 | 0.508 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.638721e-01 | 0.785 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.303017e-01 | 0.885 |
| R-HSA-5673000 | RAF activation | 3.450479e-01 | 0.462 |
| R-HSA-4641258 | Degradation of DVL | 7.625273e-02 | 1.118 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 9.153122e-02 | 1.038 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.173205e-01 | 0.499 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.244251e-01 | 0.489 |
| R-HSA-68877 | Mitotic Prometaphase | 6.964336e-02 | 1.157 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.076107e-01 | 0.968 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.317241e-01 | 0.635 |
| R-HSA-4086400 | PCP/CE pathway | 2.224853e-01 | 0.653 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 7.330425e-02 | 1.135 |
| R-HSA-9930044 | Nuclear RNA decay | 3.313701e-01 | 0.480 |
| R-HSA-74158 | RNA Polymerase III Transcription | 7.330425e-02 | 1.135 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.103410e-02 | 1.091 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.998867e-02 | 1.222 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.433293e-01 | 0.844 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.433293e-01 | 0.844 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.433293e-01 | 0.844 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 1.864118e-01 | 0.730 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.112203e-01 | 0.675 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 9.343645e-02 | 1.029 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.112203e-01 | 0.675 |
| R-HSA-6805567 | Keratinization | 8.585328e-02 | 1.066 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.030355e-01 | 0.692 |
| R-HSA-8875878 | MET promotes cell motility | 7.923834e-02 | 1.101 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 9.797983e-02 | 1.009 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.163991e-01 | 0.934 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.959207e-01 | 0.529 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.382441e-01 | 0.471 |
| R-HSA-1500620 | Meiosis | 7.233176e-02 | 1.141 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.896578e-01 | 0.538 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.958798e-02 | 1.002 |
| R-HSA-525793 | Myogenesis | 2.812234e-01 | 0.551 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.962211e-01 | 0.707 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.080362e-01 | 0.966 |
| R-HSA-177929 | Signaling by EGFR | 1.417105e-01 | 0.849 |
| R-HSA-2161517 | Abacavir transmembrane transport | 8.862760e-02 | 1.052 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.947663e-01 | 0.710 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.959207e-01 | 0.529 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.431323e-01 | 0.614 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.031569e-01 | 0.518 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.103192e-01 | 0.508 |
| R-HSA-9842663 | Signaling by LTK | 1.521234e-01 | 0.818 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.942657e-02 | 1.049 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.031569e-01 | 0.518 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.450479e-01 | 0.462 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.155771e-01 | 0.666 |
| R-HSA-182971 | EGFR downregulation | 3.174084e-01 | 0.498 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.313701e-01 | 0.480 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.167532e-01 | 0.933 |
| R-HSA-6806834 | Signaling by MET | 2.300444e-01 | 0.638 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.072367e-01 | 0.970 |
| R-HSA-429947 | Deadenylation of mRNA | 2.662211e-01 | 0.575 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.563338e-01 | 0.591 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 1.559273e-01 | 0.807 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.970682e-01 | 0.705 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.300444e-01 | 0.638 |
| R-HSA-9757110 | Prednisone ADME | 2.959207e-01 | 0.529 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.277979e-01 | 0.893 |
| R-HSA-1500931 | Cell-Cell communication | 2.666445e-01 | 0.574 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 7.917898e-02 | 1.101 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.694435e-01 | 0.771 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 6.190353e-02 | 1.208 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.112203e-01 | 0.675 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.523472e-01 | 0.817 |
| R-HSA-190236 | Signaling by FGFR | 3.097697e-01 | 0.509 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.031569e-01 | 0.518 |
| R-HSA-373755 | Semaphorin interactions | 1.667612e-01 | 0.778 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.030355e-01 | 0.692 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.030355e-01 | 0.692 |
| R-HSA-74160 | Gene expression (Transcription) | 3.116278e-01 | 0.506 |
| R-HSA-422475 | Axon guidance | 6.944529e-02 | 1.158 |
| R-HSA-199991 | Membrane Trafficking | 1.547341e-01 | 0.810 |
| R-HSA-170968 | Frs2-mediated activation | 1.608279e-01 | 0.794 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.248524e-01 | 0.488 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.910610e-01 | 0.719 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.254680e-01 | 0.901 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.193215e-01 | 0.659 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.812234e-01 | 0.551 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.886097e-01 | 0.540 |
| R-HSA-983189 | Kinesins | 1.559273e-01 | 0.807 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.688653e-01 | 0.772 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.248524e-01 | 0.488 |
| R-HSA-9675108 | Nervous system development | 9.554337e-02 | 1.020 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.373688e-01 | 0.625 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.273400e-01 | 0.643 |
| R-HSA-1474165 | Reproduction | 1.918544e-01 | 0.717 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.362486e-02 | 1.078 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 8.840749e-02 | 1.054 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.352767e-01 | 0.628 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.352767e-01 | 0.628 |
| R-HSA-70171 | Glycolysis | 3.173205e-01 | 0.499 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.202556e-02 | 1.284 |
| R-HSA-1640170 | Cell Cycle | 1.340509e-01 | 0.873 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 9.797983e-02 | 1.009 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.354277e-02 | 1.197 |
| R-HSA-9839394 | TGFBR3 expression | 2.737608e-01 | 0.563 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.490082e-01 | 0.604 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.310642e-01 | 0.480 |
| R-HSA-162582 | Signal Transduction | 8.327347e-02 | 1.079 |
| R-HSA-1266738 | Developmental Biology | 1.107351e-01 | 0.956 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.886097e-01 | 0.540 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.103192e-01 | 0.508 |
| R-HSA-169893 | Prolonged ERK activation events | 1.864118e-01 | 0.730 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.431323e-01 | 0.614 |
| R-HSA-2161522 | Abacavir ADME | 2.812234e-01 | 0.551 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.892610e-01 | 0.723 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.103192e-01 | 0.508 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.867017e-02 | 1.313 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.667612e-01 | 0.778 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.450479e-01 | 0.462 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.232864e-01 | 0.490 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 2.509077e-01 | 0.600 |
| R-HSA-9754706 | Atorvastatin ADME | 1.864118e-01 | 0.730 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.273400e-01 | 0.643 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.031569e-01 | 0.518 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.450479e-01 | 0.462 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.262624e-01 | 0.645 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.509077e-01 | 0.600 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.313701e-01 | 0.480 |
| R-HSA-191273 | Cholesterol biosynthesis | 2.224853e-01 | 0.653 |
| R-HSA-186763 | Downstream signal transduction | 3.174084e-01 | 0.498 |
| R-HSA-166520 | Signaling by NTRKs | 9.386663e-02 | 1.027 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.841022e-01 | 0.735 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.264932e-01 | 0.645 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.586037e-01 | 0.587 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.812234e-01 | 0.551 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.450479e-01 | 0.462 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.962211e-01 | 0.707 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.886097e-01 | 0.540 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.662211e-01 | 0.575 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.662211e-01 | 0.575 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.183111e-01 | 0.497 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.886097e-01 | 0.540 |
| R-HSA-1538133 | G0 and Early G1 | 3.244251e-01 | 0.489 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.315421e-02 | 1.365 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.111872e-01 | 0.675 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.566105e-01 | 0.591 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.794299e-01 | 0.554 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.457370e-01 | 0.461 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.473125e-01 | 0.459 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.473125e-01 | 0.459 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.517821e-01 | 0.454 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.517821e-01 | 0.454 |
| R-HSA-187687 | Signalling to ERKs | 3.517821e-01 | 0.454 |
| R-HSA-212436 | Generic Transcription Pathway | 3.569096e-01 | 0.447 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.584475e-01 | 0.446 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.584475e-01 | 0.446 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.650448e-01 | 0.438 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.650448e-01 | 0.438 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.650448e-01 | 0.438 |
| R-HSA-446728 | Cell junction organization | 3.690336e-01 | 0.433 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.715747e-01 | 0.430 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.780378e-01 | 0.422 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.780378e-01 | 0.422 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.780378e-01 | 0.422 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.780378e-01 | 0.422 |
| R-HSA-201556 | Signaling by ALK | 3.780378e-01 | 0.422 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.780378e-01 | 0.422 |
| R-HSA-9609690 | HCMV Early Events | 3.820559e-01 | 0.418 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.841686e-01 | 0.415 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.844348e-01 | 0.415 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.844348e-01 | 0.415 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.844348e-01 | 0.415 |
| R-HSA-167169 | HIV Transcription Elongation | 3.844348e-01 | 0.415 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.844348e-01 | 0.415 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.844348e-01 | 0.415 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.844348e-01 | 0.415 |
| R-HSA-5260271 | Diseases of Immune System | 3.844348e-01 | 0.415 |
| R-HSA-9646399 | Aggrephagy | 3.844348e-01 | 0.415 |
| R-HSA-202433 | Generation of second messenger molecules | 3.844348e-01 | 0.415 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.858071e-01 | 0.414 |
| R-HSA-8953854 | Metabolism of RNA | 3.887681e-01 | 0.410 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.907664e-01 | 0.408 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.907664e-01 | 0.408 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.907664e-01 | 0.408 |
| R-HSA-9694548 | Maturation of spike protein | 3.907664e-01 | 0.408 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.907664e-01 | 0.408 |
| R-HSA-70326 | Glucose metabolism | 3.914367e-01 | 0.407 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.946172e-01 | 0.404 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.970333e-01 | 0.401 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.970333e-01 | 0.401 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.970333e-01 | 0.401 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.032361e-01 | 0.394 |
| R-HSA-165159 | MTOR signalling | 4.032361e-01 | 0.394 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.032361e-01 | 0.394 |
| R-HSA-73928 | Depyrimidination | 4.032361e-01 | 0.394 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.032361e-01 | 0.394 |
| R-HSA-3371556 | Cellular response to heat stress | 4.058568e-01 | 0.392 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.059345e-01 | 0.392 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.093755e-01 | 0.388 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.108241e-01 | 0.386 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.154521e-01 | 0.381 |
| R-HSA-373752 | Netrin-1 signaling | 4.154521e-01 | 0.381 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.214666e-01 | 0.375 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.214666e-01 | 0.375 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.214666e-01 | 0.375 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.214666e-01 | 0.375 |
| R-HSA-194138 | Signaling by VEGF | 4.236498e-01 | 0.373 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.274195e-01 | 0.369 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.274195e-01 | 0.369 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.333115e-01 | 0.363 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.391433e-01 | 0.357 |
| R-HSA-70263 | Gluconeogenesis | 4.391433e-01 | 0.357 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.391433e-01 | 0.357 |
| R-HSA-9766229 | Degradation of CDH1 | 4.449154e-01 | 0.352 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.449154e-01 | 0.352 |
| R-HSA-418990 | Adherens junctions interactions | 4.450659e-01 | 0.352 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.506285e-01 | 0.346 |
| R-HSA-9909396 | Circadian clock | 4.515370e-01 | 0.345 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.618799e-01 | 0.335 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.618799e-01 | 0.335 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.618799e-01 | 0.335 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.674194e-01 | 0.330 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.685771e-01 | 0.329 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.685771e-01 | 0.329 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.729022e-01 | 0.325 |
| R-HSA-8957322 | Metabolism of steroids | 4.745595e-01 | 0.324 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.786502e-01 | 0.320 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.837001e-01 | 0.315 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.837001e-01 | 0.315 |
| R-HSA-1632852 | Macroautophagy | 4.853011e-01 | 0.314 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.890162e-01 | 0.311 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.890162e-01 | 0.311 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.918996e-01 | 0.308 |
| R-HSA-9033241 | Peroxisomal protein import | 4.994860e-01 | 0.301 |
| R-HSA-191859 | snRNP Assembly | 4.994860e-01 | 0.301 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.994860e-01 | 0.301 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.994860e-01 | 0.301 |
| R-HSA-186712 | Regulation of beta-cell development | 4.994860e-01 | 0.301 |
| R-HSA-379724 | tRNA Aminoacylation | 5.046406e-01 | 0.297 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.046406e-01 | 0.297 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.046406e-01 | 0.297 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.097424e-01 | 0.293 |
| R-HSA-69242 | S Phase | 5.113744e-01 | 0.291 |
| R-HSA-9758941 | Gastrulation | 5.145727e-01 | 0.289 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.147920e-01 | 0.288 |
| R-HSA-9707616 | Heme signaling | 5.147920e-01 | 0.288 |
| R-HSA-186797 | Signaling by PDGF | 5.147920e-01 | 0.288 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.197899e-01 | 0.284 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.197899e-01 | 0.284 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.197899e-01 | 0.284 |
| R-HSA-8848021 | Signaling by PTK6 | 5.197899e-01 | 0.284 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.240850e-01 | 0.281 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.249412e-01 | 0.280 |
| R-HSA-9609646 | HCMV Infection | 5.281504e-01 | 0.277 |
| R-HSA-421270 | Cell-cell junction organization | 5.306380e-01 | 0.275 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.334723e-01 | 0.273 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.344787e-01 | 0.272 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.344787e-01 | 0.272 |
| R-HSA-9612973 | Autophagy | 5.365734e-01 | 0.270 |
| R-HSA-9610379 | HCMV Late Events | 5.396605e-01 | 0.268 |
| R-HSA-162587 | HIV Life Cycle | 5.396605e-01 | 0.268 |
| R-HSA-167172 | Transcription of the HIV genome | 5.440222e-01 | 0.264 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.488367e-01 | 0.261 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.533712e-01 | 0.257 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.533712e-01 | 0.257 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.533712e-01 | 0.257 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.533712e-01 | 0.257 |
| R-HSA-975634 | Retinoid metabolism and transport | 5.579740e-01 | 0.253 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.608726e-01 | 0.251 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.625297e-01 | 0.250 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.625297e-01 | 0.250 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.670387e-01 | 0.246 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.670387e-01 | 0.246 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.670387e-01 | 0.246 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.670387e-01 | 0.246 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.715014e-01 | 0.243 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.715014e-01 | 0.243 |
| R-HSA-380287 | Centrosome maturation | 5.759185e-01 | 0.240 |
| R-HSA-8852135 | Protein ubiquitination | 5.759185e-01 | 0.240 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.759185e-01 | 0.240 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.813832e-01 | 0.236 |
| R-HSA-72306 | tRNA processing | 5.813832e-01 | 0.236 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.846173e-01 | 0.233 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.889000e-01 | 0.230 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.889000e-01 | 0.230 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.889000e-01 | 0.230 |
| R-HSA-216083 | Integrin cell surface interactions | 5.889000e-01 | 0.230 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.899571e-01 | 0.229 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.899571e-01 | 0.229 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.973340e-01 | 0.224 |
| R-HSA-977225 | Amyloid fiber formation | 6.014864e-01 | 0.221 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.014864e-01 | 0.221 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.014864e-01 | 0.221 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.055961e-01 | 0.218 |
| R-HSA-168255 | Influenza Infection | 6.067145e-01 | 0.217 |
| R-HSA-2559583 | Cellular Senescence | 6.094567e-01 | 0.215 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.096637e-01 | 0.215 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.136897e-01 | 0.212 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.216181e-01 | 0.206 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.216181e-01 | 0.206 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.255215e-01 | 0.204 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.255215e-01 | 0.204 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.293848e-01 | 0.201 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.308750e-01 | 0.200 |
| R-HSA-156902 | Peptide chain elongation | 6.332085e-01 | 0.198 |
| R-HSA-9663891 | Selective autophagy | 6.332085e-01 | 0.198 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.332085e-01 | 0.198 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.369930e-01 | 0.196 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.386693e-01 | 0.195 |
| R-HSA-195721 | Signaling by WNT | 6.387485e-01 | 0.195 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.407387e-01 | 0.193 |
| R-HSA-73884 | Base Excision Repair | 6.407387e-01 | 0.193 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.412388e-01 | 0.193 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.444459e-01 | 0.191 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.444459e-01 | 0.191 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.481152e-01 | 0.188 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.513738e-01 | 0.186 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.517468e-01 | 0.186 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.517468e-01 | 0.186 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.517468e-01 | 0.186 |
| R-HSA-1474290 | Collagen formation | 6.588986e-01 | 0.181 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.624195e-01 | 0.179 |
| R-HSA-428157 | Sphingolipid metabolism | 6.637232e-01 | 0.178 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.659044e-01 | 0.177 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.659044e-01 | 0.177 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.659044e-01 | 0.177 |
| R-HSA-2168880 | Scavenging of heme from plasma | 6.659044e-01 | 0.177 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.693534e-01 | 0.174 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.693534e-01 | 0.174 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.761458e-01 | 0.170 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.794897e-01 | 0.168 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.794897e-01 | 0.168 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.827994e-01 | 0.166 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.860750e-01 | 0.164 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.887452e-01 | 0.162 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.893171e-01 | 0.162 |
| R-HSA-397014 | Muscle contraction | 6.919341e-01 | 0.160 |
| R-HSA-192823 | Viral mRNA Translation | 6.925259e-01 | 0.160 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.941953e-01 | 0.159 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.957017e-01 | 0.158 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.957017e-01 | 0.158 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 6.988449e-01 | 0.156 |
| R-HSA-9833110 | RSV-host interactions | 6.988449e-01 | 0.156 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.080822e-01 | 0.150 |
| R-HSA-211000 | Gene Silencing by RNA | 7.080822e-01 | 0.150 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.110983e-01 | 0.148 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.110983e-01 | 0.148 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.110983e-01 | 0.148 |
| R-HSA-202403 | TCR signaling | 7.170379e-01 | 0.144 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.170379e-01 | 0.144 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.228560e-01 | 0.141 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.228560e-01 | 0.141 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.228560e-01 | 0.141 |
| R-HSA-162906 | HIV Infection | 7.244413e-01 | 0.140 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.265027e-01 | 0.139 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.285553e-01 | 0.138 |
| R-HSA-6798695 | Neutrophil degranulation | 7.288454e-01 | 0.137 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.313610e-01 | 0.136 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.341380e-01 | 0.134 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.341380e-01 | 0.134 |
| R-HSA-72312 | rRNA processing | 7.346188e-01 | 0.134 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.350974e-01 | 0.134 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.396066e-01 | 0.131 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.396066e-01 | 0.131 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.422988e-01 | 0.129 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.422988e-01 | 0.129 |
| R-HSA-8939211 | ESR-mediated signaling | 7.444769e-01 | 0.128 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.476005e-01 | 0.126 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.476005e-01 | 0.126 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.553505e-01 | 0.122 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.553505e-01 | 0.122 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.578809e-01 | 0.120 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.603852e-01 | 0.119 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.653170e-01 | 0.116 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.653170e-01 | 0.116 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.653170e-01 | 0.116 |
| R-HSA-69206 | G1/S Transition | 7.653170e-01 | 0.116 |
| R-HSA-114608 | Platelet degranulation | 7.701478e-01 | 0.113 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.791357e-01 | 0.108 |
| R-HSA-9843745 | Adipogenesis | 7.817969e-01 | 0.107 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.825354e-01 | 0.106 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.862904e-01 | 0.104 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.887428e-01 | 0.103 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.971260e-01 | 0.098 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.992267e-01 | 0.097 |
| R-HSA-449147 | Signaling by Interleukins | 7.993068e-01 | 0.097 |
| R-HSA-6807070 | PTEN Regulation | 8.013057e-01 | 0.096 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.053998e-01 | 0.094 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.094100e-01 | 0.092 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.171857e-01 | 0.088 |
| R-HSA-9658195 | Leishmania infection | 8.184583e-01 | 0.087 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.184583e-01 | 0.087 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.190799e-01 | 0.087 |
| R-HSA-2187338 | Visual phototransduction | 8.190799e-01 | 0.087 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.198933e-01 | 0.086 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.209545e-01 | 0.086 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.246460e-01 | 0.084 |
| R-HSA-9609507 | Protein localization | 8.300419e-01 | 0.081 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.300419e-01 | 0.081 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.318036e-01 | 0.080 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.318036e-01 | 0.080 |
| R-HSA-73887 | Death Receptor Signaling | 8.318036e-01 | 0.080 |
| R-HSA-1989781 | PPARA activates gene expression | 8.335472e-01 | 0.079 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.369806e-01 | 0.077 |
| R-HSA-9711097 | Cellular response to starvation | 8.386708e-01 | 0.076 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.419991e-01 | 0.075 |
| R-HSA-2262752 | Cellular responses to stress | 8.458997e-01 | 0.073 |
| R-HSA-5619102 | SLC transporter disorders | 8.531197e-01 | 0.069 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.559950e-01 | 0.068 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.620301e-01 | 0.064 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.648792e-01 | 0.063 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.674310e-01 | 0.062 |
| R-HSA-1474244 | Extracellular matrix organization | 8.788842e-01 | 0.056 |
| R-HSA-69275 | G2/M Transition | 8.807863e-01 | 0.055 |
| R-HSA-112316 | Neuronal System | 8.825723e-01 | 0.054 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.832502e-01 | 0.054 |
| R-HSA-5617833 | Cilium Assembly | 8.856635e-01 | 0.053 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.970059e-01 | 0.047 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.991365e-01 | 0.046 |
| R-HSA-73894 | DNA Repair | 9.048610e-01 | 0.043 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.072308e-01 | 0.042 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.100948e-01 | 0.041 |
| R-HSA-9824446 | Viral Infection Pathways | 9.111788e-01 | 0.040 |
| R-HSA-9748784 | Drug ADME | 9.155645e-01 | 0.038 |
| R-HSA-8951664 | Neddylation | 9.181740e-01 | 0.037 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.376805e-01 | 0.028 |
| R-HSA-9679506 | SARS-CoV Infections | 9.384743e-01 | 0.028 |
| R-HSA-5688426 | Deubiquitination | 9.426946e-01 | 0.026 |
| R-HSA-72766 | Translation | 9.477584e-01 | 0.023 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.500013e-01 | 0.022 |
| R-HSA-1643685 | Disease | 9.506462e-01 | 0.022 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.530536e-01 | 0.021 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.584054e-01 | 0.018 |
| R-HSA-1280218 | Adaptive Immune System | 9.668802e-01 | 0.015 |
| R-HSA-109582 | Hemostasis | 9.685217e-01 | 0.014 |
| R-HSA-5663205 | Infectious disease | 9.709278e-01 | 0.013 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.719583e-01 | 0.012 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.724833e-01 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.818027e-01 | 0.008 |
| R-HSA-597592 | Post-translational protein modification | 9.827476e-01 | 0.008 |
| R-HSA-913531 | Interferon Signaling | 9.852693e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.863205e-01 | 0.006 |
| R-HSA-168249 | Innate Immune System | 9.879407e-01 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 9.885732e-01 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.902523e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.905313e-01 | 0.004 |
| R-HSA-168256 | Immune System | 9.925933e-01 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 9.978464e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.986971e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.990402e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.993215e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999766e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999986e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1E |
0.786 | 0.450 | -3 | 0.694 |
CK1D |
0.783 | 0.452 | -3 | 0.693 |
CK1A2 |
0.783 | 0.451 | -3 | 0.690 |
CK1A |
0.776 | 0.426 | -3 | 0.684 |
CK1G1 |
0.773 | 0.382 | -3 | 0.680 |
COT |
0.771 | 0.212 | 2 | 0.845 |
GRK1 |
0.770 | 0.294 | -2 | 0.806 |
KIS |
0.761 | 0.108 | 1 | 0.568 |
GRK7 |
0.757 | 0.235 | 1 | 0.682 |
CLK3 |
0.756 | 0.090 | 1 | 0.683 |
BMPR1B |
0.755 | 0.248 | 1 | 0.762 |
GRK4 |
0.754 | 0.236 | -2 | 0.827 |
GRK3 |
0.754 | 0.259 | -2 | 0.718 |
GRK6 |
0.754 | 0.287 | 1 | 0.745 |
MTOR |
0.753 | 0.125 | 1 | 0.688 |
MOS |
0.753 | 0.160 | 1 | 0.726 |
GRK5 |
0.752 | 0.253 | -3 | 0.471 |
CDC7 |
0.752 | 0.143 | 1 | 0.734 |
GRK2 |
0.749 | 0.237 | -2 | 0.729 |
IKKB |
0.749 | 0.063 | -2 | 0.675 |
CK1G2 |
0.748 | 0.355 | -3 | 0.679 |
CK1G3 |
0.748 | 0.382 | -3 | 0.670 |
PIM3 |
0.747 | 0.035 | -3 | 0.362 |
DSTYK |
0.746 | 0.057 | 2 | 0.868 |
SKMLCK |
0.745 | 0.069 | -2 | 0.808 |
CLK2 |
0.745 | 0.076 | -3 | 0.312 |
NDR2 |
0.744 | 0.019 | -3 | 0.354 |
CAMK2G |
0.741 | 0.080 | 2 | 0.779 |
RSK2 |
0.741 | 0.034 | -3 | 0.297 |
PRPK |
0.739 | -0.010 | -1 | 0.854 |
IKKA |
0.739 | 0.061 | -2 | 0.682 |
FAM20C |
0.739 | 0.066 | 2 | 0.597 |
RAF1 |
0.739 | 0.008 | 1 | 0.729 |
RIPK3 |
0.739 | 0.011 | 3 | 0.403 |
SRPK1 |
0.738 | -0.010 | -3 | 0.309 |
IKKE |
0.738 | -0.019 | 1 | 0.652 |
MLK1 |
0.738 | 0.074 | 2 | 0.799 |
ATR |
0.737 | 0.033 | 1 | 0.697 |
TBK1 |
0.737 | -0.036 | 1 | 0.652 |
GCN2 |
0.736 | -0.068 | 2 | 0.781 |
PDHK4 |
0.736 | -0.046 | 1 | 0.733 |
CK2A2 |
0.735 | 0.156 | 1 | 0.679 |
CK2A1 |
0.735 | 0.183 | 1 | 0.677 |
CDK1 |
0.735 | 0.068 | 1 | 0.563 |
ACVR2B |
0.734 | 0.169 | -2 | 0.751 |
TGFBR1 |
0.733 | 0.104 | -2 | 0.757 |
GSK3A |
0.733 | 0.187 | 4 | 0.678 |
SRPK3 |
0.733 | -0.006 | -3 | 0.308 |
BMPR1A |
0.733 | 0.172 | 1 | 0.727 |
BMPR2 |
0.732 | -0.005 | -2 | 0.803 |
HUNK |
0.732 | -0.028 | 2 | 0.829 |
CAMK1B |
0.732 | -0.023 | -3 | 0.354 |
DLK |
0.732 | 0.169 | 1 | 0.731 |
PASK |
0.731 | 0.204 | -3 | 0.385 |
NLK |
0.731 | -0.021 | 1 | 0.709 |
NEK7 |
0.731 | -0.058 | -3 | 0.380 |
P90RSK |
0.731 | -0.010 | -3 | 0.302 |
CDKL1 |
0.731 | -0.028 | -3 | 0.326 |
ACVR2A |
0.731 | 0.159 | -2 | 0.737 |
RSK4 |
0.731 | 0.037 | -3 | 0.295 |
NDR1 |
0.731 | -0.039 | -3 | 0.340 |
PIM1 |
0.730 | 0.006 | -3 | 0.341 |
GSK3B |
0.730 | 0.180 | 4 | 0.671 |
TTBK2 |
0.729 | 0.036 | 2 | 0.706 |
WNK1 |
0.729 | -0.028 | -2 | 0.804 |
NEK6 |
0.728 | -0.073 | -2 | 0.815 |
SRPK2 |
0.728 | -0.026 | -3 | 0.268 |
MST4 |
0.728 | -0.011 | 2 | 0.813 |
PKN2 |
0.728 | -0.009 | -3 | 0.350 |
MSK1 |
0.728 | 0.030 | -3 | 0.297 |
CAMK2B |
0.728 | 0.063 | 2 | 0.753 |
ALK4 |
0.728 | 0.095 | -2 | 0.774 |
PLK1 |
0.727 | 0.062 | -2 | 0.739 |
TGFBR2 |
0.727 | -0.026 | -2 | 0.761 |
RSK3 |
0.727 | -0.028 | -3 | 0.287 |
PKACG |
0.727 | -0.008 | -2 | 0.675 |
MEKK3 |
0.727 | 0.184 | 1 | 0.709 |
CAMK2A |
0.727 | 0.062 | 2 | 0.778 |
DRAK1 |
0.726 | 0.128 | 1 | 0.763 |
ERK5 |
0.726 | -0.034 | 1 | 0.673 |
BCKDK |
0.726 | -0.058 | -1 | 0.820 |
ALK2 |
0.726 | 0.105 | -2 | 0.774 |
ATM |
0.726 | 0.008 | 1 | 0.640 |
PRKX |
0.725 | 0.022 | -3 | 0.282 |
CAMLCK |
0.725 | -0.032 | -2 | 0.762 |
MASTL |
0.725 | -0.038 | -2 | 0.740 |
NUAK2 |
0.725 | -0.048 | -3 | 0.353 |
PKACB |
0.724 | 0.008 | -2 | 0.614 |
MLK4 |
0.724 | 0.069 | 2 | 0.715 |
CLK4 |
0.724 | 0.002 | -3 | 0.322 |
DAPK2 |
0.724 | -0.016 | -3 | 0.357 |
MLK3 |
0.724 | 0.014 | 2 | 0.733 |
CDKL5 |
0.723 | -0.041 | -3 | 0.312 |
CHAK2 |
0.723 | -0.036 | -1 | 0.789 |
NIK |
0.723 | -0.066 | -3 | 0.371 |
PKN3 |
0.723 | -0.066 | -3 | 0.328 |
ULK2 |
0.723 | -0.139 | 2 | 0.748 |
HIPK4 |
0.723 | -0.037 | 1 | 0.656 |
MSK2 |
0.723 | -0.021 | -3 | 0.305 |
TLK2 |
0.722 | 0.038 | 1 | 0.688 |
RIPK1 |
0.722 | -0.036 | 1 | 0.686 |
PDHK1 |
0.722 | -0.160 | 1 | 0.706 |
MYLK4 |
0.722 | 0.011 | -2 | 0.700 |
AURC |
0.722 | 0.000 | -2 | 0.600 |
P70S6KB |
0.722 | -0.035 | -3 | 0.312 |
ANKRD3 |
0.721 | -0.018 | 1 | 0.725 |
MARK4 |
0.721 | -0.060 | 4 | 0.862 |
PLK3 |
0.720 | 0.019 | 2 | 0.760 |
LATS1 |
0.720 | 0.023 | -3 | 0.353 |
DNAPK |
0.720 | 0.039 | 1 | 0.611 |
AURA |
0.720 | 0.025 | -2 | 0.588 |
YSK4 |
0.720 | 0.028 | 1 | 0.685 |
MEK1 |
0.719 | 0.105 | 2 | 0.826 |
ICK |
0.719 | -0.034 | -3 | 0.342 |
CAMK2D |
0.719 | -0.036 | -3 | 0.322 |
DYRK2 |
0.719 | -0.012 | 1 | 0.591 |
LATS2 |
0.718 | -0.045 | -5 | 0.765 |
JNK3 |
0.718 | 0.025 | 1 | 0.557 |
MST3 |
0.718 | 0.119 | 2 | 0.827 |
SMG1 |
0.718 | 0.018 | 1 | 0.655 |
PAK1 |
0.718 | -0.029 | -2 | 0.700 |
MAPKAPK2 |
0.717 | -0.044 | -3 | 0.275 |
ULK1 |
0.717 | -0.111 | -3 | 0.347 |
NEK9 |
0.716 | -0.110 | 2 | 0.802 |
CLK1 |
0.715 | -0.024 | -3 | 0.284 |
CDK8 |
0.715 | -0.027 | 1 | 0.575 |
P38G |
0.715 | 0.026 | 1 | 0.482 |
CDK3 |
0.715 | 0.014 | 1 | 0.499 |
PLK2 |
0.715 | 0.073 | -3 | 0.372 |
CDK2 |
0.715 | 0.010 | 1 | 0.635 |
PKCD |
0.715 | -0.056 | 2 | 0.755 |
PKCB |
0.715 | -0.020 | 2 | 0.720 |
IRE1 |
0.714 | -0.066 | 1 | 0.656 |
NIM1 |
0.714 | -0.079 | 3 | 0.399 |
HIPK2 |
0.714 | 0.001 | 1 | 0.521 |
JNK2 |
0.714 | 0.025 | 1 | 0.535 |
AMPKA1 |
0.714 | -0.086 | -3 | 0.348 |
WNK3 |
0.714 | -0.159 | 1 | 0.693 |
CDK5 |
0.714 | -0.004 | 1 | 0.593 |
YANK3 |
0.713 | 0.156 | 2 | 0.422 |
PKCG |
0.713 | -0.021 | 2 | 0.732 |
DYRK4 |
0.713 | 0.014 | 1 | 0.533 |
AKT2 |
0.713 | -0.029 | -3 | 0.268 |
MLK2 |
0.713 | -0.090 | 2 | 0.786 |
PRP4 |
0.713 | -0.004 | -3 | 0.364 |
P38B |
0.712 | 0.029 | 1 | 0.536 |
CDK13 |
0.712 | -0.018 | 1 | 0.553 |
PRKD1 |
0.712 | -0.092 | -3 | 0.304 |
CDK19 |
0.711 | -0.025 | 1 | 0.545 |
CDK18 |
0.710 | 0.008 | 1 | 0.523 |
PRKD2 |
0.710 | -0.080 | -3 | 0.276 |
GAK |
0.710 | 0.164 | 1 | 0.730 |
ERK1 |
0.710 | 0.008 | 1 | 0.530 |
JNK1 |
0.709 | 0.035 | 1 | 0.531 |
PKCA |
0.709 | -0.026 | 2 | 0.710 |
TLK1 |
0.709 | 0.021 | -2 | 0.812 |
VRK2 |
0.709 | -0.094 | 1 | 0.723 |
MEKK2 |
0.709 | 0.064 | 2 | 0.771 |
P38A |
0.709 | 0.005 | 1 | 0.597 |
QSK |
0.709 | -0.051 | 4 | 0.828 |
PKR |
0.709 | -0.041 | 1 | 0.695 |
SGK3 |
0.708 | -0.044 | -3 | 0.296 |
AURB |
0.708 | -0.026 | -2 | 0.597 |
TAO3 |
0.708 | 0.039 | 1 | 0.695 |
MARK3 |
0.707 | -0.024 | 4 | 0.808 |
PAK3 |
0.707 | -0.080 | -2 | 0.681 |
HIPK1 |
0.707 | -0.017 | 1 | 0.605 |
CAMK4 |
0.707 | -0.090 | -3 | 0.336 |
GCK |
0.707 | 0.131 | 1 | 0.741 |
AMPKA2 |
0.707 | -0.100 | -3 | 0.324 |
BRSK1 |
0.706 | -0.068 | -3 | 0.305 |
PAK2 |
0.706 | -0.059 | -2 | 0.683 |
MAPKAPK3 |
0.706 | -0.120 | -3 | 0.285 |
CDK12 |
0.706 | -0.018 | 1 | 0.532 |
DAPK1 |
0.706 | 0.041 | -3 | 0.336 |
PKACA |
0.706 | -0.022 | -2 | 0.562 |
PKG2 |
0.706 | -0.043 | -2 | 0.603 |
PLK4 |
0.705 | -0.050 | 2 | 0.629 |
CDK17 |
0.705 | 0.004 | 1 | 0.485 |
CAMK1G |
0.705 | -0.053 | -3 | 0.293 |
MEK5 |
0.705 | -0.019 | 2 | 0.794 |
ZAK |
0.704 | -0.001 | 1 | 0.675 |
PKCZ |
0.704 | -0.064 | 2 | 0.756 |
QIK |
0.704 | -0.106 | -3 | 0.337 |
PKCH |
0.704 | -0.057 | 2 | 0.707 |
PIM2 |
0.704 | -0.047 | -3 | 0.284 |
P38D |
0.703 | 0.017 | 1 | 0.478 |
NEK11 |
0.703 | 0.056 | 1 | 0.702 |
TSSK2 |
0.703 | -0.092 | -5 | 0.768 |
CDK7 |
0.703 | -0.044 | 1 | 0.577 |
MNK2 |
0.703 | -0.076 | -2 | 0.698 |
HPK1 |
0.702 | 0.105 | 1 | 0.725 |
CDK10 |
0.702 | 0.010 | 1 | 0.552 |
TSSK1 |
0.702 | -0.101 | -3 | 0.349 |
ERK2 |
0.702 | -0.017 | 1 | 0.578 |
MNK1 |
0.701 | -0.069 | -2 | 0.698 |
MEKK1 |
0.701 | -0.074 | 1 | 0.686 |
PAK6 |
0.701 | -0.041 | -2 | 0.602 |
DYRK1A |
0.701 | -0.048 | 1 | 0.612 |
MARK2 |
0.700 | -0.053 | 4 | 0.772 |
SIK |
0.700 | -0.087 | -3 | 0.299 |
DCAMKL1 |
0.700 | -0.074 | -3 | 0.310 |
NEK2 |
0.700 | -0.124 | 2 | 0.786 |
CDK14 |
0.700 | -0.008 | 1 | 0.566 |
PHKG1 |
0.700 | -0.110 | -3 | 0.340 |
CHAK1 |
0.699 | -0.119 | 2 | 0.736 |
NEK5 |
0.699 | -0.078 | 1 | 0.701 |
IRE2 |
0.699 | -0.124 | 2 | 0.700 |
DAPK3 |
0.699 | -0.005 | -3 | 0.334 |
TTBK1 |
0.698 | -0.040 | 2 | 0.625 |
MPSK1 |
0.698 | -0.008 | 1 | 0.660 |
TAK1 |
0.697 | 0.129 | 1 | 0.713 |
DYRK3 |
0.697 | -0.036 | 1 | 0.602 |
DYRK1B |
0.697 | -0.033 | 1 | 0.570 |
MARK1 |
0.697 | -0.066 | 4 | 0.815 |
CDK9 |
0.697 | -0.052 | 1 | 0.557 |
BRSK2 |
0.697 | -0.113 | -3 | 0.311 |
SMMLCK |
0.697 | -0.047 | -3 | 0.321 |
MAPKAPK5 |
0.696 | -0.126 | -3 | 0.267 |
PERK |
0.696 | -0.106 | -2 | 0.773 |
WNK4 |
0.696 | -0.101 | -2 | 0.798 |
MST2 |
0.696 | 0.028 | 1 | 0.717 |
SGK1 |
0.695 | -0.026 | -3 | 0.234 |
PRKD3 |
0.694 | -0.111 | -3 | 0.272 |
AKT1 |
0.694 | -0.054 | -3 | 0.273 |
CDK16 |
0.694 | -0.003 | 1 | 0.496 |
YANK2 |
0.694 | 0.172 | 2 | 0.436 |
MELK |
0.694 | -0.150 | -3 | 0.301 |
BRAF |
0.693 | -0.083 | -4 | 0.733 |
SNRK |
0.693 | -0.160 | 2 | 0.655 |
NUAK1 |
0.692 | -0.134 | -3 | 0.298 |
NEK8 |
0.692 | -0.059 | 2 | 0.788 |
HRI |
0.692 | -0.159 | -2 | 0.777 |
EEF2K |
0.692 | 0.006 | 3 | 0.453 |
MAK |
0.692 | 0.002 | -2 | 0.681 |
P70S6K |
0.691 | -0.074 | -3 | 0.256 |
KHS2 |
0.691 | 0.049 | 1 | 0.717 |
HIPK3 |
0.691 | -0.067 | 1 | 0.596 |
PKCE |
0.691 | -0.034 | 2 | 0.717 |
PINK1 |
0.690 | -0.158 | 1 | 0.689 |
DCAMKL2 |
0.690 | -0.080 | -3 | 0.309 |
MINK |
0.690 | 0.014 | 1 | 0.700 |
PAK4 |
0.690 | -0.034 | -2 | 0.577 |
AKT3 |
0.690 | -0.040 | -3 | 0.241 |
STK33 |
0.689 | -0.024 | 2 | 0.626 |
ERK7 |
0.688 | 0.006 | 2 | 0.581 |
PDK1 |
0.688 | -0.069 | 1 | 0.658 |
CAMKK1 |
0.687 | -0.094 | -2 | 0.646 |
BMPR2_TYR |
0.686 | 0.210 | -1 | 0.883 |
PKCT |
0.686 | -0.090 | 2 | 0.703 |
PAK5 |
0.686 | -0.057 | -2 | 0.565 |
TAO2 |
0.686 | -0.086 | 2 | 0.806 |
TNIK |
0.685 | -0.039 | 3 | 0.450 |
IRAK4 |
0.685 | -0.137 | 1 | 0.652 |
MAP2K6_TYR |
0.685 | 0.265 | -1 | 0.864 |
PDHK4_TYR |
0.685 | 0.243 | 2 | 0.833 |
VRK1 |
0.684 | -0.042 | 2 | 0.804 |
PKCI |
0.684 | -0.073 | 2 | 0.732 |
CAMK1D |
0.684 | -0.087 | -3 | 0.248 |
MAP3K15 |
0.684 | -0.043 | 1 | 0.660 |
KHS1 |
0.684 | -0.001 | 1 | 0.691 |
MST1 |
0.683 | -0.020 | 1 | 0.698 |
HGK |
0.683 | -0.062 | 3 | 0.463 |
PDHK3_TYR |
0.683 | 0.171 | 4 | 0.910 |
LKB1 |
0.683 | -0.103 | -3 | 0.354 |
PDHK1_TYR |
0.683 | 0.226 | -1 | 0.870 |
OSR1 |
0.682 | 0.032 | 2 | 0.775 |
ROCK2 |
0.681 | -0.045 | -3 | 0.319 |
SLK |
0.681 | -0.042 | -2 | 0.637 |
CAMKK2 |
0.680 | -0.102 | -2 | 0.637 |
NEK4 |
0.680 | -0.125 | 1 | 0.679 |
MEKK6 |
0.680 | -0.095 | 1 | 0.698 |
SSTK |
0.680 | -0.100 | 4 | 0.812 |
IRAK1 |
0.680 | -0.179 | -1 | 0.747 |
PHKG2 |
0.679 | -0.135 | -3 | 0.306 |
TTK |
0.679 | 0.042 | -2 | 0.788 |
CHK2 |
0.679 | -0.080 | -3 | 0.232 |
LRRK2 |
0.679 | -0.081 | 2 | 0.819 |
CDK6 |
0.679 | -0.037 | 1 | 0.538 |
MRCKA |
0.679 | -0.055 | -3 | 0.291 |
TXK |
0.678 | 0.146 | 1 | 0.762 |
MRCKB |
0.678 | -0.062 | -3 | 0.279 |
MAP2K4_TYR |
0.678 | 0.131 | -1 | 0.867 |
DMPK1 |
0.677 | -0.023 | -3 | 0.301 |
CHK1 |
0.677 | -0.186 | -3 | 0.298 |
ALPHAK3 |
0.674 | 0.078 | -1 | 0.762 |
LOK |
0.673 | -0.105 | -2 | 0.658 |
PKN1 |
0.672 | -0.101 | -3 | 0.264 |
MOK |
0.672 | -0.050 | 1 | 0.612 |
NEK1 |
0.672 | -0.164 | 1 | 0.673 |
RIPK2 |
0.672 | -0.166 | 1 | 0.626 |
FYN |
0.671 | 0.108 | -1 | 0.844 |
CDK4 |
0.671 | -0.051 | 1 | 0.521 |
FGR |
0.670 | 0.089 | 1 | 0.735 |
SYK |
0.670 | 0.194 | -1 | 0.803 |
MAP2K7_TYR |
0.670 | -0.026 | 2 | 0.821 |
YSK1 |
0.670 | -0.085 | 2 | 0.774 |
PTK2 |
0.669 | 0.166 | -1 | 0.822 |
CAMK1A |
0.669 | -0.094 | -3 | 0.233 |
MEK2 |
0.668 | -0.168 | 2 | 0.778 |
HASPIN |
0.667 | -0.027 | -1 | 0.674 |
PBK |
0.667 | -0.058 | 1 | 0.657 |
TESK1_TYR |
0.667 | -0.068 | 3 | 0.464 |
EPHA6 |
0.667 | 0.004 | -1 | 0.876 |
ROCK1 |
0.666 | -0.061 | -3 | 0.292 |
EPHB4 |
0.666 | 0.001 | -1 | 0.848 |
PKMYT1_TYR |
0.666 | -0.070 | 3 | 0.448 |
INSRR |
0.666 | 0.012 | 3 | 0.368 |
YES1 |
0.665 | 0.003 | -1 | 0.836 |
SBK |
0.665 | -0.076 | -3 | 0.196 |
FLT1 |
0.665 | 0.085 | -1 | 0.830 |
BLK |
0.664 | 0.027 | -1 | 0.847 |
CRIK |
0.664 | -0.050 | -3 | 0.263 |
PINK1_TYR |
0.663 | -0.086 | 1 | 0.708 |
EPHA4 |
0.662 | 0.018 | 2 | 0.773 |
FER |
0.661 | -0.001 | 1 | 0.730 |
LCK |
0.661 | 0.001 | -1 | 0.853 |
SRMS |
0.661 | 0.022 | 1 | 0.734 |
KIT |
0.661 | 0.001 | 3 | 0.391 |
PKG1 |
0.660 | -0.089 | -2 | 0.504 |
ABL2 |
0.660 | -0.032 | -1 | 0.807 |
MYO3A |
0.660 | -0.054 | 1 | 0.679 |
ITK |
0.660 | 0.007 | -1 | 0.818 |
MYO3B |
0.659 | -0.074 | 2 | 0.783 |
ABL1 |
0.659 | -0.017 | -1 | 0.801 |
HCK |
0.659 | -0.029 | -1 | 0.847 |
MET |
0.658 | 0.024 | 3 | 0.375 |
BMX |
0.658 | 0.034 | -1 | 0.750 |
EPHB1 |
0.658 | -0.020 | 1 | 0.721 |
CSF1R |
0.658 | -0.076 | 3 | 0.378 |
ASK1 |
0.658 | -0.096 | 1 | 0.645 |
SRC |
0.658 | 0.045 | -1 | 0.828 |
EPHB2 |
0.658 | -0.005 | -1 | 0.830 |
KDR |
0.657 | -0.037 | 3 | 0.369 |
RET |
0.657 | -0.139 | 1 | 0.673 |
ZAP70 |
0.655 | 0.129 | -1 | 0.732 |
DDR1 |
0.655 | -0.109 | 4 | 0.839 |
ERBB4 |
0.654 | 0.084 | 1 | 0.618 |
MERTK |
0.654 | -0.024 | 3 | 0.368 |
FGFR3 |
0.654 | -0.004 | 3 | 0.401 |
EPHB3 |
0.654 | -0.047 | -1 | 0.841 |
FGFR2 |
0.654 | -0.055 | 3 | 0.425 |
MST1R |
0.654 | -0.157 | 3 | 0.389 |
TYRO3 |
0.654 | -0.130 | 3 | 0.378 |
ERBB2 |
0.653 | -0.002 | 1 | 0.659 |
JAK3 |
0.653 | -0.078 | 1 | 0.667 |
TEC |
0.652 | -0.022 | -1 | 0.759 |
LIMK2_TYR |
0.652 | -0.172 | -3 | 0.352 |
STLK3 |
0.652 | -0.068 | 1 | 0.645 |
BUB1 |
0.651 | -0.107 | -5 | 0.716 |
TNK2 |
0.651 | -0.100 | 3 | 0.376 |
ROS1 |
0.651 | -0.162 | 3 | 0.360 |
TAO1 |
0.651 | -0.124 | 1 | 0.628 |
EPHA7 |
0.651 | -0.022 | 2 | 0.767 |
NEK3 |
0.650 | -0.217 | 1 | 0.638 |
PTK2B |
0.649 | 0.016 | -1 | 0.790 |
LYN |
0.649 | -0.032 | 3 | 0.355 |
JAK2 |
0.649 | -0.193 | 1 | 0.661 |
EPHA5 |
0.649 | -0.000 | 2 | 0.753 |
BIKE |
0.649 | -0.052 | 1 | 0.627 |
EPHA8 |
0.649 | -0.003 | -1 | 0.835 |
TYK2 |
0.648 | -0.227 | 1 | 0.666 |
EGFR |
0.648 | 0.014 | 1 | 0.580 |
EPHA3 |
0.648 | -0.032 | 2 | 0.738 |
WEE1_TYR |
0.648 | -0.025 | -1 | 0.766 |
FGFR4 |
0.648 | 0.016 | -1 | 0.767 |
LIMK1_TYR |
0.648 | -0.228 | 2 | 0.803 |
DDR2 |
0.647 | -0.061 | 3 | 0.379 |
FRK |
0.647 | -0.041 | -1 | 0.845 |
NTRK1 |
0.646 | -0.090 | -1 | 0.821 |
INSR |
0.645 | -0.069 | 3 | 0.350 |
BTK |
0.645 | -0.109 | -1 | 0.783 |
FLT3 |
0.645 | -0.124 | 3 | 0.384 |
MATK |
0.644 | -0.005 | -1 | 0.723 |
PDGFRB |
0.643 | -0.161 | 3 | 0.388 |
NTRK3 |
0.642 | -0.066 | -1 | 0.782 |
AXL |
0.641 | -0.118 | 3 | 0.370 |
IGF1R |
0.641 | -0.026 | 3 | 0.324 |
FLT4 |
0.641 | -0.092 | 3 | 0.384 |
EPHA2 |
0.640 | -0.011 | -1 | 0.803 |
ALK |
0.640 | -0.130 | 3 | 0.339 |
FGFR1 |
0.639 | -0.155 | 3 | 0.366 |
TEK |
0.639 | -0.158 | 3 | 0.353 |
JAK1 |
0.639 | -0.149 | 1 | 0.637 |
LTK |
0.639 | -0.130 | 3 | 0.356 |
CSK |
0.639 | -0.042 | 2 | 0.767 |
NTRK2 |
0.638 | -0.144 | 3 | 0.364 |
PTK6 |
0.636 | -0.122 | -1 | 0.749 |
NEK10_TYR |
0.635 | -0.157 | 1 | 0.599 |
EPHA1 |
0.635 | -0.128 | 3 | 0.353 |
TNK1 |
0.632 | -0.199 | 3 | 0.373 |
FES |
0.632 | 0.012 | -1 | 0.732 |
PDGFRA |
0.630 | -0.241 | 3 | 0.383 |
TNNI3K_TYR |
0.630 | -0.147 | 1 | 0.645 |
AAK1 |
0.628 | -0.042 | 1 | 0.541 |
MUSK |
0.620 | -0.123 | 1 | 0.582 |