Motif 463 (n=202)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A0A0C4DFX4	None	T237	ochoa	Snf2 related CREBBP activator protein	None
O00571	DDX3X	Y69	ochoa	ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)	Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250\|UniProtKB:Q62167, ECO:0000269\|PubMed:16818630, ECO:0000269\|PubMed:17095540, ECO:0000269\|PubMed:17357160, ECO:0000269\|PubMed:17667941, ECO:0000269\|PubMed:18264132, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:18596238, ECO:0000269\|PubMed:18628297, ECO:0000269\|PubMed:18636090, ECO:0000269\|PubMed:18846110, ECO:0000269\|PubMed:19913487, ECO:0000269\|PubMed:20127681, ECO:0000269\|PubMed:20837705, ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:21730191, ECO:0000269\|PubMed:21883093, ECO:0000269\|PubMed:22323517, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:23413191, ECO:0000269\|PubMed:23478265, ECO:0000269\|PubMed:27736973, ECO:0000269\|PubMed:27980081, ECO:0000269\|PubMed:28128295, ECO:0000269\|PubMed:28842590, ECO:0000269\|PubMed:29062139, ECO:0000269\|PubMed:29222110, ECO:0000269\|PubMed:30256975, ECO:0000269\|PubMed:30341167, ECO:0000269\|PubMed:31575075, ECO:0000269\|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269\|PubMed:15507209, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269\|PubMed:27105836}.
O00571	DDX3X	S70	ochoa\|psp	ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)	Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250\|UniProtKB:Q62167, ECO:0000269\|PubMed:16818630, ECO:0000269\|PubMed:17095540, ECO:0000269\|PubMed:17357160, ECO:0000269\|PubMed:17667941, ECO:0000269\|PubMed:18264132, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:18596238, ECO:0000269\|PubMed:18628297, ECO:0000269\|PubMed:18636090, ECO:0000269\|PubMed:18846110, ECO:0000269\|PubMed:19913487, ECO:0000269\|PubMed:20127681, ECO:0000269\|PubMed:20837705, ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:21730191, ECO:0000269\|PubMed:21883093, ECO:0000269\|PubMed:22323517, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:23413191, ECO:0000269\|PubMed:23478265, ECO:0000269\|PubMed:27736973, ECO:0000269\|PubMed:27980081, ECO:0000269\|PubMed:28128295, ECO:0000269\|PubMed:28842590, ECO:0000269\|PubMed:29062139, ECO:0000269\|PubMed:29222110, ECO:0000269\|PubMed:30256975, ECO:0000269\|PubMed:30341167, ECO:0000269\|PubMed:31575075, ECO:0000269\|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269\|PubMed:15507209, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269\|PubMed:27105836}.
O00571	DDX3X	S71	ochoa\|psp	ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)	Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250\|UniProtKB:Q62167, ECO:0000269\|PubMed:16818630, ECO:0000269\|PubMed:17095540, ECO:0000269\|PubMed:17357160, ECO:0000269\|PubMed:17667941, ECO:0000269\|PubMed:18264132, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:18596238, ECO:0000269\|PubMed:18628297, ECO:0000269\|PubMed:18636090, ECO:0000269\|PubMed:18846110, ECO:0000269\|PubMed:19913487, ECO:0000269\|PubMed:20127681, ECO:0000269\|PubMed:20837705, ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:21730191, ECO:0000269\|PubMed:21883093, ECO:0000269\|PubMed:22323517, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:23413191, ECO:0000269\|PubMed:23478265, ECO:0000269\|PubMed:27736973, ECO:0000269\|PubMed:27980081, ECO:0000269\|PubMed:28128295, ECO:0000269\|PubMed:28842590, ECO:0000269\|PubMed:29062139, ECO:0000269\|PubMed:29222110, ECO:0000269\|PubMed:30256975, ECO:0000269\|PubMed:30341167, ECO:0000269\|PubMed:31575075, ECO:0000269\|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269\|PubMed:15507209, ECO:0000269\|PubMed:18583960, ECO:0000269\|PubMed:21589879, ECO:0000269\|PubMed:22872150, ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269\|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269\|PubMed:27105836}.
O14526	FCHO1	S576	ochoa	F-BAR domain only protein 1	Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269\|PubMed:20448150, ECO:0000269\|PubMed:30822429, ECO:0000269\|PubMed:32098969}.
O14974	PPP1R12A	S896	ochoa	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269\|PubMed:18477460, ECO:0000269\|PubMed:19245366, ECO:0000269\|PubMed:20354225}.
O15075	DCLK1	S355	ochoa	Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)	Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
O15085	ARHGEF11	S225	ochoa	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269\|PubMed:21670212}.
O43683	BUB1	S445	ochoa	Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)	Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269\|PubMed:10198256, ECO:0000269\|PubMed:15020684, ECO:0000269\|PubMed:15525512, ECO:0000269\|PubMed:15723797, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:17158872, ECO:0000269\|PubMed:19487456, ECO:0000269\|PubMed:20739936, ECO:0000269\|PubMed:35044816}.
O43719	HTATSF1	S397	ochoa	17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269\|PubMed:10454543, ECO:0000269\|PubMed:10913173, ECO:0000269\|PubMed:11780068, ECO:0000269\|PubMed:30567737, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:34822310, ECO:0000269\|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269\|PubMed:10393184, ECO:0000269\|PubMed:11420046, ECO:0000269\|PubMed:15905670, ECO:0000269\|PubMed:8849451, ECO:0000269\|PubMed:9765201}.
O60307	MAST3	S91	ochoa	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)	None
O60307	MAST3	S100	ochoa	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)	None
O75044	SRGAP2	S860	ochoa	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)	Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250\|UniProtKB:Q91Z67, ECO:0000269\|PubMed:20810653, ECO:0000269\|PubMed:21148482, ECO:0000269\|PubMed:22559944, ECO:0000269\|PubMed:27373832, ECO:0000269\|PubMed:28333212}.
O75369	FLNB	S2487	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75381	PEX14	S268	ochoa	Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)	Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250\|UniProtKB:P53112, ECO:0000269\|PubMed:21525035, ECO:0000269\|PubMed:24235149, ECO:0000269\|PubMed:28765278, ECO:0000269\|PubMed:9653144}.
O95071	UBR5	S1741	ochoa	E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)	E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250\|UniProtKB:Q80TP3, ECO:0000269\|PubMed:11714696, ECO:0000269\|PubMed:21118991, ECO:0000269\|PubMed:21127351, ECO:0000269\|PubMed:21726808, ECO:0000269\|PubMed:22884692, ECO:0000269\|PubMed:28689657, ECO:0000269\|PubMed:29033132, ECO:0000269\|PubMed:29378950, ECO:0000269\|PubMed:33208877, ECO:0000269\|PubMed:35217622, ECO:0000269\|PubMed:37409633, ECO:0000269\|PubMed:37478846, ECO:0000269\|PubMed:37478862}.
O95155	UBE4B	S87	ochoa	Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)	Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250\|UniProtKB:P54860, ECO:0000250\|UniProtKB:Q9ES00, ECO:0000269\|PubMed:17369820}.
O95155	UBE4B	S92	ochoa	Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)	Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250\|UniProtKB:P54860, ECO:0000250\|UniProtKB:Q9ES00, ECO:0000269\|PubMed:17369820}.
P00533	EGFR	S1045	ochoa	Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250\|UniProtKB:Q01279, ECO:0000269\|PubMed:10805725, ECO:0000269\|PubMed:11116146, ECO:0000269\|PubMed:11483589, ECO:0000269\|PubMed:11602604, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12873986, ECO:0000269\|PubMed:15374980, ECO:0000269\|PubMed:15590694, ECO:0000269\|PubMed:15611079, ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:17909029, ECO:0000269\|PubMed:19560417, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:21258366, ECO:0000269\|PubMed:27153536, ECO:0000269\|PubMed:2790960, ECO:0000269\|PubMed:35538033, ECO:0000269\|PubMed:7679104, ECO:0000269\|PubMed:8144591, ECO:0000269\|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.
P02545	LMNA	S398	ochoa	Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	[Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269\|PubMed:10080180, ECO:0000269\|PubMed:10580070, ECO:0000269\|PubMed:10587585, ECO:0000269\|PubMed:10814726, ECO:0000269\|PubMed:11799477, ECO:0000269\|PubMed:12075506, ECO:0000269\|PubMed:12927431, ECO:0000269\|PubMed:15317753, ECO:0000269\|PubMed:18551513, ECO:0000269\|PubMed:18611980, ECO:0000269\|PubMed:2188730, ECO:0000269\|PubMed:22431096, ECO:0000269\|PubMed:2344612, ECO:0000269\|PubMed:23666920, ECO:0000269\|PubMed:23990565, ECO:0000269\|PubMed:24741066, ECO:0000269\|PubMed:25127216, ECO:0000269\|PubMed:31434876, ECO:0000269\|PubMed:31548606, ECO:0000269\|PubMed:37788673, ECO:0000269\|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269\|PubMed:20458013}.
P02545	LMNA	S414	ochoa	Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	[Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269\|PubMed:10080180, ECO:0000269\|PubMed:10580070, ECO:0000269\|PubMed:10587585, ECO:0000269\|PubMed:10814726, ECO:0000269\|PubMed:11799477, ECO:0000269\|PubMed:12075506, ECO:0000269\|PubMed:12927431, ECO:0000269\|PubMed:15317753, ECO:0000269\|PubMed:18551513, ECO:0000269\|PubMed:18611980, ECO:0000269\|PubMed:2188730, ECO:0000269\|PubMed:22431096, ECO:0000269\|PubMed:2344612, ECO:0000269\|PubMed:23666920, ECO:0000269\|PubMed:23990565, ECO:0000269\|PubMed:24741066, ECO:0000269\|PubMed:25127216, ECO:0000269\|PubMed:31434876, ECO:0000269\|PubMed:31548606, ECO:0000269\|PubMed:37788673, ECO:0000269\|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269\|PubMed:20458013}.
P02671	FGA	S285	ochoa	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250\|UniProtKB:E9PV24}.
P02671	FGA	S542	ochoa\|psp	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250\|UniProtKB:E9PV24}.
P02671	FGA	S585	ochoa	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250\|UniProtKB:E9PV24}.
P04049	RAF1	S612	ochoa	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)	Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269\|PubMed:11427728, ECO:0000269\|PubMed:11719507, ECO:0000269\|PubMed:15385642, ECO:0000269\|PubMed:15618521, ECO:0000269\|PubMed:15849194, ECO:0000269\|PubMed:16892053, ECO:0000269\|PubMed:16924233, ECO:0000269\|PubMed:9360956}.
P05783	KRT18	S42	ochoa	Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269\|PubMed:15529338, ECO:0000269\|PubMed:16424149, ECO:0000269\|PubMed:17213200, ECO:0000269\|PubMed:7523419, ECO:0000269\|PubMed:8522591, ECO:0000269\|PubMed:9298992, ECO:0000269\|PubMed:9524113}.
P08238	HSP90AB1	S468	ochoa	Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269\|PubMed:16478993, ECO:0000269\|PubMed:18239673, ECO:0000269\|PubMed:19696785, ECO:0000269\|PubMed:20353823, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:32272059, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269\|PubMed:21949862, ECO:0000305\|PubMed:22066472}.
P08670	VIM	T33	ochoa	Vimentin	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250\|UniProtKB:A0A8C0N8E3, ECO:0000250\|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269\|PubMed:21746880}.
P08670	VIM	S42	ochoa\|psp	Vimentin	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250\|UniProtKB:A0A8C0N8E3, ECO:0000250\|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269\|PubMed:21746880}.
P12270	TPR	S637	ochoa	Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269\|PubMed:11952838, ECO:0000269\|PubMed:15654337, ECO:0000269\|PubMed:17897941, ECO:0000269\|PubMed:18794356, ECO:0000269\|PubMed:18981471, ECO:0000269\|PubMed:19273613, ECO:0000269\|PubMed:20133940, ECO:0000269\|PubMed:20407419, ECO:0000269\|PubMed:21613532, ECO:0000269\|PubMed:22253824, ECO:0000269\|PubMed:9864356}.
P13807	GYS1	S718	ochoa	Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1)	Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269\|PubMed:35835870}.
P16144	ITGB4	S1465	ochoa	Integrin beta-4 (GP150) (CD antigen CD104)	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:22351760, ECO:0000269\|PubMed:28873464}.
P16144	ITGB4	S1474	ochoa	Integrin beta-4 (GP150) (CD antigen CD104)	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:22351760, ECO:0000269\|PubMed:28873464}.
P16144	ITGB4	Y1492	ochoa\|psp	Integrin beta-4 (GP150) (CD antigen CD104)	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:22351760, ECO:0000269\|PubMed:28873464}.
P16144	ITGB4	S1494	ochoa\|psp	Integrin beta-4 (GP150) (CD antigen CD104)	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:22351760, ECO:0000269\|PubMed:28873464}.
P17302	GJA1	S314	ochoa	Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250\|UniProtKB:P08050, ECO:0000250\|UniProtKB:P23242}.
P18084	ITGB5	S770	ochoa	Integrin beta-5	Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. {ECO:0000269\|PubMed:20615244}.
P18887	XRCC1	S210	ochoa\|psp	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269\|PubMed:11163244, ECO:0000269\|PubMed:14500814, ECO:0000269\|PubMed:28002403, ECO:0000269\|PubMed:34102106, ECO:0000269\|PubMed:34811483}.
P23588	EIF4B	S433	ochoa	Eukaryotic translation initiation factor 4B (eIF-4B)	Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P23677	ITPKA	S132	ochoa	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)	Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269\|PubMed:12747803, ECO:0000269\|PubMed:15350214, ECO:0000269\|PubMed:1847047}.
P25116	F2R	S400	ochoa\|psp	Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)	High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (PubMed:10079109). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed:30568593, PubMed:34831181). {ECO:0000250\|UniProtKB:P26824, ECO:0000250\|UniProtKB:P30558, ECO:0000269\|PubMed:10079109, ECO:0000269\|PubMed:1672265, ECO:0000269\|PubMed:30568593, ECO:0000269\|PubMed:34831181, ECO:0000269\|PubMed:8136362}.
P35372	OPRM1	S365	psp	Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)	Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250\|UniProtKB:P33535, ECO:0000269\|PubMed:10529478, ECO:0000269\|PubMed:12068084, ECO:0000269\|PubMed:12589820, ECO:0000269\|PubMed:7891175, ECO:0000269\|PubMed:7905839, ECO:0000269\|PubMed:7957926, ECO:0000269\|PubMed:9689128, ECO:0000303\|PubMed:10836142, ECO:0000303\|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269\|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269\|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269\|PubMed:16580639}.
P38159	RBMX	S315	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P38159	RBMX	S316	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P38159	RBMX	S323	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P38398	BRCA1	S1466	ochoa	Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)	E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269\|PubMed:10500182, ECO:0000269\|PubMed:10724175, ECO:0000269\|PubMed:11836499, ECO:0000269\|PubMed:12183412, ECO:0000269\|PubMed:12887909, ECO:0000269\|PubMed:12890688, ECO:0000269\|PubMed:14976165, ECO:0000269\|PubMed:16326698, ECO:0000269\|PubMed:16818604, ECO:0000269\|PubMed:17525340, ECO:0000269\|PubMed:18056443, ECO:0000269\|PubMed:19261748, ECO:0000269\|PubMed:19369211, ECO:0000269\|PubMed:20160719, ECO:0000269\|PubMed:20351172}.
P42166	TMPO	S167	ochoa	Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]	May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P42166	TMPO	S168	ochoa	Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]	May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P42166	TMPO	S354	ochoa	Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]	May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P43243	MATR3	S62	ochoa	Matrin-3	May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269\|PubMed:11525732, ECO:0000269\|PubMed:28431233, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:32245947}.
P46937	YAP1	S388	ochoa\|psp	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250\|UniProtKB:P46938, ECO:0000269\|PubMed:16772533, ECO:0000269\|PubMed:17974916, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:18280240, ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:21364637, ECO:0000269\|PubMed:25778702, ECO:0000269\|PubMed:25849865, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:30447097, ECO:0000269\|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.
P46937	YAP1	Y391	ochoa\|psp	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250\|UniProtKB:P46938, ECO:0000269\|PubMed:16772533, ECO:0000269\|PubMed:17974916, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:18280240, ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:21364637, ECO:0000269\|PubMed:25778702, ECO:0000269\|PubMed:25849865, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:30447097, ECO:0000269\|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.
P49790	NUP153	S225	ochoa	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269\|PubMed:12802065, ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269\|PubMed:23523133, ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:31913756}.
P50851	LRBA	S1072	ochoa	Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)	Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250\|UniProtKB:Q9ESE1, ECO:0000269\|PubMed:33773106}.
P55196	AFDN	S1317	ochoa	Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)	Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250\|UniProtKB:O35889, ECO:0000250\|UniProtKB:Q9QZQ1, ECO:0000269\|PubMed:11024295, ECO:0000269\|PubMed:30463011}.
P61073	CXCR4	S330	psp	C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250\|UniProtKB:P70658, ECO:0000269\|PubMed:10074102, ECO:0000269\|PubMed:10452968, ECO:0000269\|PubMed:10644702, ECO:0000269\|PubMed:10825158, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:17197449, ECO:0000269\|PubMed:18799424, ECO:0000269\|PubMed:20048153, ECO:0000269\|PubMed:20228059, ECO:0000269\|PubMed:20505072, ECO:0000269\|PubMed:24912431, ECO:0000269\|PubMed:28978524, ECO:0000269\|PubMed:8752280, ECO:0000269\|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609). {ECO:0000269\|PubMed:10074122, ECO:0000269\|PubMed:10756055, ECO:0000269\|PubMed:8849450, ECO:0000269\|PubMed:8929542, ECO:0000269\|PubMed:9427609}.
P78527	PRKDC	S2663	ochoa	DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460)	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250\|UniProtKB:P97313, ECO:0000269\|PubMed:10026262, ECO:0000269\|PubMed:10467406, ECO:0000269\|PubMed:11889123, ECO:0000269\|PubMed:11955432, ECO:0000269\|PubMed:12509254, ECO:0000269\|PubMed:12649176, ECO:0000269\|PubMed:14599745, ECO:0000269\|PubMed:14612514, ECO:0000269\|PubMed:14627815, ECO:0000269\|PubMed:14704337, ECO:0000269\|PubMed:14734805, ECO:0000269\|PubMed:15177042, ECO:0000269\|PubMed:15262962, ECO:0000269\|PubMed:15574326, ECO:0000269\|PubMed:1597196, ECO:0000269\|PubMed:16046194, ECO:0000269\|PubMed:16397295, ECO:0000269\|PubMed:18644470, ECO:0000269\|PubMed:2247066, ECO:0000269\|PubMed:2507541, ECO:0000269\|PubMed:26237645, ECO:0000269\|PubMed:26666690, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:29478807, ECO:0000269\|PubMed:30247612, ECO:0000269\|PubMed:32103174, ECO:0000269\|PubMed:33273464, ECO:0000269\|PubMed:33854234, ECO:0000269\|PubMed:34352203, ECO:0000269\|PubMed:35460603, ECO:0000269\|PubMed:8407951, ECO:0000269\|PubMed:8464713, ECO:0000269\|PubMed:9139719, ECO:0000269\|PubMed:9362500, ECO:0000269\|PubMed:9363941, ECO:0000269\|PubMed:9679063}.
Q02880	TOP2B	S1457	ochoa	DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)	Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269\|PubMed:10684600, ECO:0000269\|PubMed:31409799, ECO:0000269\|PubMed:32128574}.
Q03252	LMNB2	S415	ochoa	Lamin-B2	Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269\|PubMed:33033404}.
Q08AD1	CAMSAP2	S1301	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q09666	AHNAK	S5851	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q13242	SRSF9	S195	ochoa	Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)	Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269\|PubMed:10196175, ECO:0000269\|PubMed:11875052, ECO:0000269\|PubMed:12024014, ECO:0000269\|PubMed:12604611, ECO:0000269\|PubMed:15009090, ECO:0000269\|PubMed:15009664, ECO:0000269\|PubMed:15695522, ECO:0000269\|PubMed:7556075}.
Q13480	GAB1	Y265	ochoa	GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269\|PubMed:29408807}.
Q13620	CUL4B	S53	ochoa	Cullin-4B (CUL-4B)	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269\|PubMed:14578910, ECO:0000269\|PubMed:16322693, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:18235224, ECO:0000269\|PubMed:18593899, ECO:0000269\|PubMed:19801544, ECO:0000269\|PubMed:22118460, ECO:0000269\|PubMed:26711351, ECO:0000269\|PubMed:29779948, ECO:0000269\|PubMed:30166453, ECO:0000269\|PubMed:33854232, ECO:0000269\|PubMed:33854239}.
Q13620	CUL4B	S69	ochoa	Cullin-4B (CUL-4B)	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269\|PubMed:14578910, ECO:0000269\|PubMed:16322693, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:18235224, ECO:0000269\|PubMed:18593899, ECO:0000269\|PubMed:19801544, ECO:0000269\|PubMed:22118460, ECO:0000269\|PubMed:26711351, ECO:0000269\|PubMed:29779948, ECO:0000269\|PubMed:30166453, ECO:0000269\|PubMed:33854232, ECO:0000269\|PubMed:33854239}.
Q13620	CUL4B	S70	ochoa	Cullin-4B (CUL-4B)	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269\|PubMed:14578910, ECO:0000269\|PubMed:16322693, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:18235224, ECO:0000269\|PubMed:18593899, ECO:0000269\|PubMed:19801544, ECO:0000269\|PubMed:22118460, ECO:0000269\|PubMed:26711351, ECO:0000269\|PubMed:29779948, ECO:0000269\|PubMed:30166453, ECO:0000269\|PubMed:33854232, ECO:0000269\|PubMed:33854239}.
Q13761	RUNX3	S211	ochoa	Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)	Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250\|UniProtKB:Q64131, ECO:0000269\|PubMed:20599712}.
Q13796	SHROOM2	S159	ochoa	Protein Shroom2 (Apical-like protein) (Protein APXL)	May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q13835	PKP1	S127	psp	Plakophilin-1 (Band 6 protein) (B6P)	A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250\|UniProtKB:P97350, ECO:0000269\|PubMed:10852826, ECO:0000269\|PubMed:20156963, ECO:0000269\|PubMed:20613778, ECO:0000269\|PubMed:23444369, ECO:0000269\|PubMed:25225333, ECO:0000269\|PubMed:31835537, ECO:0000269\|PubMed:9326952}.
Q14155	ARHGEF7	S147	ochoa	Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)	Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269\|PubMed:18184567, ECO:0000269\|PubMed:18716323, ECO:0000269\|PubMed:19041750}.
Q14155	ARHGEF7	S167	ochoa	Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)	Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269\|PubMed:18184567, ECO:0000269\|PubMed:18716323, ECO:0000269\|PubMed:19041750}.
Q14161	GIT2	S565	ochoa	ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)	GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269\|PubMed:10896954}.
Q14181	POLA2	S138	ochoa	DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)	Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250\|UniProtKB:P09884, ECO:0000250\|UniProtKB:P20664, ECO:0000269\|PubMed:9705292}.
Q14677	CLINT1	S311	ochoa	Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)	Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269\|PubMed:12429846, ECO:0000269\|PubMed:12538641}.
Q14683	SMC1A	S957	ochoa\|psp	Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)	Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269\|PubMed:11877377}.
Q14966	ZNF638	S636	ochoa	Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein)	Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250\|UniProtKB:Q61464, ECO:0000269\|PubMed:30487602, ECO:0000269\|PubMed:8647861}.
Q15003	NCAPH	S78	ochoa	Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog)	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269\|PubMed:11136719, ECO:0000269\|PubMed:27737959}.
Q15052	ARHGEF6	S131	ochoa	Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)	Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Q15149	PLEC	S4657	ochoa	Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)	Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:21109228}.
Q15555	MAPRE2	S216	ochoa	Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)	Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250\|UniProtKB:Q8R001, ECO:0000269\|PubMed:22373814, ECO:0000269\|PubMed:23844040, ECO:0000269\|PubMed:26527684, ECO:0000269\|PubMed:27030108}.
Q15596	NCOA2	S668	ochoa	Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)	Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250\|UniProtKB:Q61026, ECO:0000269\|PubMed:22504882, ECO:0000269\|PubMed:23508108, ECO:0000269\|PubMed:26553876, ECO:0000269\|PubMed:8670870, ECO:0000269\|PubMed:9430642}.
Q16512	PKN1	S567	ochoa	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)	PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269\|PubMed:11104762, ECO:0000269\|PubMed:12514133, ECO:0000269\|PubMed:17332740, ECO:0000269\|PubMed:18066052, ECO:0000269\|PubMed:20188095, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:21754995, ECO:0000269\|PubMed:24248594, ECO:0000269\|PubMed:8557118, ECO:0000269\|PubMed:8621664, ECO:0000269\|PubMed:9175763}.
Q5JSZ5	PRRC2B	S232	ochoa	Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B)	None
Q5QJE6	DNTTIP2	S178	ochoa	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:12786946, ECO:0000269\|PubMed:15047147, ECO:0000269\|PubMed:34516797}.
Q5TBA9	FRY	S1946	ochoa	Protein furry homolog	Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269\|PubMed:22753416}.
Q5UIP0	RIF1	S1157	ochoa	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250\|UniProtKB:Q6PR54, ECO:0000269\|PubMed:15342490, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:28241136}.
Q5VT52	RPRD2	S605	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q5VT52	RPRD2	S936	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q658Y4	FAM91A1	S355	ochoa	Protein FAM91A1	As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269\|PubMed:29426865}.
Q6PIJ6	FBXO38	S724	ochoa	F-box only protein 38	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250\|UniProtKB:Q8BMI0, ECO:0000269\|PubMed:30487606}.
Q6UUV7	CRTC3	S329	ochoa\|psp	CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:14506290, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:15466468, ECO:0000269\|PubMed:16817901, ECO:0000269\|PubMed:16980408, ECO:0000269\|PubMed:17210223, ECO:0000269\|PubMed:17644518}.
Q6UUV9	CRTC1	S158	ochoa	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250\|UniProtKB:Q157S1, ECO:0000250\|UniProtKB:Q68ED7, ECO:0000269\|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:16809310}.
Q6XZF7	DNMBP	S1370	ochoa	Dynamin-binding protein (Scaffold protein Tuba)	Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250\|UniProtKB:E2RP94, ECO:0000250\|UniProtKB:Q6TXD4, ECO:0000269\|PubMed:17015620, ECO:0000269\|PubMed:19767742, ECO:0000269\|PubMed:20479467}.
Q6ZRS2	SRCAP	T256	ochoa	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269\|PubMed:10347196, ECO:0000269\|PubMed:11522779, ECO:0000269\|PubMed:14500758, ECO:0000269\|PubMed:16024792, ECO:0000269\|PubMed:16634648, ECO:0000269\|PubMed:17617668}.
Q70CQ2	USP34	S3394	ochoa	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34)	Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269\|PubMed:21383061}.
Q7Z2W4	ZC3HAV1	S361	ochoa	Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)	Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269\|PubMed:18225958, ECO:0000269\|PubMed:21102435, ECO:0000269\|PubMed:21876179, ECO:0000269\|PubMed:22720057}.
Q86TV6	TTC7B	S666	ochoa	Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1)	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269\|PubMed:23229899, ECO:0000269\|PubMed:26571211}.
Q86U70	LDB1	T314	ochoa	LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)	Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250\|UniProtKB:P70662}.
Q86VP3	PACS2	S337	ochoa	Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)	Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269\|PubMed:15692563, ECO:0000269\|PubMed:15692567}.
Q86YS7	C2CD5	Y292	ochoa	C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa)	Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269\|PubMed:21907143}.
Q86YV5	PRAG1	S745	ochoa	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250\|UniProtKB:D3ZMK9, ECO:0000250\|UniProtKB:Q571I4}.
Q8IUC4	RHPN2	S604	ochoa	Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)	Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269\|PubMed:12221077}.
Q8IVL1	NAV2	Y1599	ochoa	Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)	Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269\|PubMed:12214280, ECO:0000269\|PubMed:15158073}.
Q8IWS0	PHF6	S192	ochoa	PHD finger protein 6 (PHD-like zinc finger protein)	Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269\|PubMed:23229552}.
Q8IWZ3	ANKHD1	S2287	ochoa	Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)	May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269\|PubMed:16098192}.
Q8IY63	AMOTL1	S793	ochoa\|psp	Angiomotin-like protein 1	Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269\|PubMed:22362771}.
Q8N1G2	CMTR1	S37	ochoa	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)	S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269\|PubMed:18533109, ECO:0000269\|PubMed:20713356, ECO:0000269\|PubMed:21310715}.
Q8N1G2	CMTR1	S40	ochoa	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)	S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269\|PubMed:18533109, ECO:0000269\|PubMed:20713356, ECO:0000269\|PubMed:21310715}.
Q8N1G2	CMTR1	S46	ochoa	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)	S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269\|PubMed:18533109, ECO:0000269\|PubMed:20713356, ECO:0000269\|PubMed:21310715}.
Q8NC51	SERBP1	S205	ochoa	SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein)	Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250\|UniProtKB:Q9CY58, ECO:0000269\|PubMed:11001948, ECO:0000269\|PubMed:28695742, ECO:0000269\|PubMed:36691768}.
Q8NHV4	NEDD1	S557	psp	Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)	Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19509060}.
Q8NHV4	NEDD1	S574	psp	Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)	Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19509060}.
Q8NI08	NCOA7	S170	ochoa	Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1)	Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269\|PubMed:11971969}.
Q8TEW8	PARD3B	S352	ochoa	Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein)	Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WUM0	NUP133	S480	ochoa	Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)	Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269\|PubMed:11684705, ECO:0000269\|PubMed:30179222}.
Q92625	ANKS1A	S634	ochoa	Ankyrin repeat and SAM domain-containing protein 1A (Odin)	Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269\|PubMed:17875921}.
Q92625	ANKS1A	S652	ochoa	Ankyrin repeat and SAM domain-containing protein 1A (Odin)	Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269\|PubMed:17875921}.
Q92974	ARHGEF2	S133	ochoa	Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)	Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250\|UniProtKB:Q60875, ECO:0000250\|UniProtKB:Q865S3, ECO:0000269\|PubMed:19043560, ECO:0000269\|PubMed:21887730, ECO:0000269\|PubMed:28453519, ECO:0000269\|PubMed:9857026}.
Q92997	DVL3	S611	psp	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)	Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250\|UniProtKB:Q61062}.
Q96E39	RBMXL1	S315	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96E39	RBMXL1	S316	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96E39	RBMXL1	S323	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96FF9	CDCA5	S147	ochoa	Sororin (Cell division cycle-associated protein 5) (p35)	Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269\|PubMed:15837422, ECO:0000269\|PubMed:17349791, ECO:0000269\|PubMed:21111234}.
Q96HC4	PDLIM5	S385	ochoa	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)	May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250\|UniProtKB:Q62920}.
Q96JY6	PDLIM2	S129	ochoa	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)	Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269\|PubMed:15659642}.
Q96JY6	PDLIM2	S197	ochoa	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)	Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269\|PubMed:15659642}.
Q96MY1	NOL4L	S386	ochoa	Nucleolar protein 4-like	None
Q96RT1	ERBIN	S841	ochoa	Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269\|PubMed:10878805, ECO:0000269\|PubMed:16203728}.
Q96S38	RPS6KC1	S648	ochoa	Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein)	May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269\|PubMed:12077123, ECO:0000269\|PubMed:15750338}.
Q96S38	RPS6KC1	S650	ochoa	Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein)	May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269\|PubMed:12077123, ECO:0000269\|PubMed:15750338}.
Q96SU4	OSBPL9	S325	ochoa	Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)	Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269\|PubMed:39106189}.
Q96T37	RBM15	Y112	ochoa	RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)	RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250\|UniProtKB:Q0VBL3, ECO:0000269\|PubMed:17001072, ECO:0000269\|PubMed:19786495, ECO:0000269\|PubMed:26575292, ECO:0000269\|PubMed:27602518, ECO:0000305\|PubMed:11344311}.
Q99683	MAP3K5	S966	ochoa\|psp	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269\|PubMed:10411906, ECO:0000269\|PubMed:10688666, ECO:0000269\|PubMed:10849426, ECO:0000269\|PubMed:11029458, ECO:0000269\|PubMed:11154276, ECO:0000269\|PubMed:11689443, ECO:0000269\|PubMed:11920685, ECO:0000269\|PubMed:14688258, ECO:0000269\|PubMed:14749717, ECO:0000269\|PubMed:15023544, ECO:0000269\|PubMed:16129676, ECO:0000269\|PubMed:17220297, ECO:0000269\|PubMed:23102700, ECO:0000269\|PubMed:26095851, ECO:0000269\|PubMed:8940179, ECO:0000269\|PubMed:8974401, ECO:0000269\|PubMed:9564042, ECO:0000269\|PubMed:9774977}.
Q99700	ATXN2	S521	ochoa	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269\|PubMed:18602463}.
Q99700	ATXN2	S856	ochoa	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269\|PubMed:18602463}.
Q9BQE9	BCL7B	S120	ochoa	B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3)	Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250\|UniProtKB:Q921K9, ECO:0000269\|PubMed:25569233}.
Q9BXB4	OSBPL11	S178	ochoa	Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)	Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:23028956, ECO:0000269\|PubMed:39106189}.
Q9BXF6	RAB11FIP5	S367	ochoa	Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11)	Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269\|PubMed:11163216, ECO:0000269\|PubMed:20717956}.
Q9BXS6	NUSAP1	S251	ochoa	Nucleolar and spindle-associated protein 1 (NuSAP)	Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269\|PubMed:12963707}.
Q9C0B5	ZDHHC5	S406	ochoa	Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)	Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250\|UniProtKB:Q8VDZ4, ECO:0000269\|PubMed:21820437, ECO:0000269\|PubMed:26334723, ECO:0000269\|PubMed:29185452, ECO:0000269\|PubMed:31402609, ECO:0000269\|PubMed:31649195, ECO:0000269\|PubMed:32958780, ECO:0000269\|PubMed:34293401, ECO:0000269\|PubMed:38092000, ECO:0000269\|PubMed:38530158, ECO:0000269\|PubMed:38599239}.
Q9C0D5	TANC1	S1668	ochoa	Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)	May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9C0D5	TANC1	S1671	ochoa	Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)	May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H1K0	RBSN	S217	ochoa	Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)	Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269\|PubMed:11062261, ECO:0000269\|PubMed:11788822, ECO:0000269\|PubMed:15020713, ECO:0000269\|PubMed:22308388}.
Q9H4A3	WNK1	S19	ochoa	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)	Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250\|UniProtKB:P83741, ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:10660600, ECO:0000269\|PubMed:15883153, ECO:0000269\|PubMed:16263722, ECO:0000269\|PubMed:17190791, ECO:0000269\|PubMed:19665974, ECO:0000269\|PubMed:19739668, ECO:0000269\|PubMed:21220314, ECO:0000269\|PubMed:21321328, ECO:0000269\|PubMed:22989884, ECO:0000269\|PubMed:25362046, ECO:0000269\|PubMed:25477473, ECO:0000269\|PubMed:27911840, ECO:0000269\|PubMed:29196535, ECO:0000269\|PubMed:31656913, ECO:0000269\|PubMed:33964204, ECO:0000269\|PubMed:34289367, ECO:0000269\|PubMed:36318922, ECO:0000269\|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:14645531}.
Q9H4L5	OSBPL3	S309	ochoa	Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)	Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269\|PubMed:16143324, ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:18270267, ECO:0000269\|PubMed:25447204}.
Q9H4X1	RGCC	S75	ochoa	Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32)	Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269\|PubMed:11687586, ECO:0000269\|PubMed:17146433, ECO:0000269\|PubMed:19158077, ECO:0000269\|PubMed:22163048}.
Q9H5V7	IKZF5	S309	ochoa	Zinc finger protein Pegasus (Ikaros family zinc finger protein 5)	Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269\|PubMed:10978333, ECO:0000269\|PubMed:31217188}.
Q9H6T3	RPAP3	S489	ochoa	RNA polymerase II-associated protein 3	Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269\|PubMed:17643375}.
Q9H6U6	BCAS3	S877	ochoa	BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1)	Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250\|UniProtKB:Q8CCN5, ECO:0000269\|PubMed:17505058, ECO:0000269\|PubMed:33499712}.
Q9H6Z4	RANBP3	S341	ochoa	Ran-binding protein 3 (RanBP3)	Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269\|PubMed:11425870, ECO:0000269\|PubMed:11571268, ECO:0000269\|PubMed:11932251, ECO:0000269\|PubMed:19289081, ECO:0000269\|PubMed:9637251}.
Q9HB20	PLEKHA3	S230	ochoa	Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)	Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269\|PubMed:11001876, ECO:0000269\|PubMed:15107860, ECO:0000269\|PubMed:30659099}.
Q9HCK8	CHD8	Y2208	ochoa	Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)	ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255\|HAMAP-Rule:MF_03071, ECO:0000269\|PubMed:17938208, ECO:0000269\|PubMed:18378692, ECO:0000269\|PubMed:28533432, ECO:0000269\|PubMed:36537238}.
Q9NQW6	ANLN	S344	ochoa	Anillin	Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269\|PubMed:10931866, ECO:0000269\|PubMed:12479805, ECO:0000269\|PubMed:15496454, ECO:0000269\|PubMed:16040610, ECO:0000269\|PubMed:16357138, ECO:0000269\|PubMed:23870127, ECO:0000269\|PubMed:24676636}.
Q9NRR3	CDC42SE2	S43	ochoa	CDC42 small effector protein 2 (Small effector of CDC42 protein 2)	Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269\|PubMed:10816584, ECO:0000269\|PubMed:15840583}.
Q9NV70	EXOC1	S481	ochoa	Exocyst complex component 1 (Exocyst complex component Sec3)	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269\|PubMed:19889084}.
Q9NYV4	CDK12	S265	ochoa	Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269\|PubMed:11683387, ECO:0000269\|PubMed:19651820, ECO:0000269\|PubMed:20952539, ECO:0000269\|PubMed:22012619, ECO:0000269\|PubMed:24662513}.
Q9NYV4	CDK12	S274	ochoa	Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269\|PubMed:11683387, ECO:0000269\|PubMed:19651820, ECO:0000269\|PubMed:20952539, ECO:0000269\|PubMed:22012619, ECO:0000269\|PubMed:24662513}.
Q9NZB2	FAM120A	S450	ochoa	Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A)	Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269\|PubMed:19015244}.
Q9NZJ0	DTL	S496	ochoa	Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)	Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269\|PubMed:16861906, ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240, ECO:0000269\|PubMed:17085480, ECO:0000269\|PubMed:18703516, ECO:0000269\|PubMed:18794347, ECO:0000269\|PubMed:18794348, ECO:0000269\|PubMed:19332548, ECO:0000269\|PubMed:20129063, ECO:0000269\|PubMed:23478441, ECO:0000269\|PubMed:23478445, ECO:0000269\|PubMed:23677613, ECO:0000269\|PubMed:26431207, ECO:0000269\|PubMed:27906959}.
Q9P206	NHSL3	S330	ochoa	NHS-like protein 3	Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269\|PubMed:32854746}.
Q9P206	NHSL3	S333	ochoa	NHS-like protein 3	Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269\|PubMed:32854746}.
Q9P219	CCDC88C	S1592	ochoa	Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)	Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269\|PubMed:26126266, ECO:0000269\|PubMed:30948426}.
Q9UBC2	EPS15L1	S235	ochoa	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.
Q9UDT6	CLIP2	S37	ochoa	CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein)	Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UER7	DAXX	S420	ochoa	Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269\|PubMed:12140263, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:15364927, ECO:0000269\|PubMed:16845383, ECO:0000269\|PubMed:17081986, ECO:0000269\|PubMed:17942542, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:23222847, ECO:0000269\|PubMed:24200965, ECO:0000269\|PubMed:24530302}.
Q9UGV2	NDRG3	S335	ochoa	Protein NDRG3 (N-myc downstream-regulated gene 3 protein)	None
Q9UH99	SUN2	S21	ochoa	SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250\|UniProtKB:Q8BJS4, ECO:0000269\|PubMed:18396275, ECO:0000305}.
Q9UK76	JPT1	S79	ochoa	Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed]	Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269\|PubMed:21323578, ECO:0000269\|PubMed:22155408, ECO:0000269\|PubMed:25169422, ECO:0000269\|PubMed:25450365}.
Q9UKI8	TLK1	S80	ochoa	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269\|PubMed:10523312, ECO:0000269\|PubMed:10588641, ECO:0000269\|PubMed:11314006, ECO:0000269\|PubMed:11470414, ECO:0000269\|PubMed:12660173, ECO:0000269\|PubMed:9427565}.
Q9UKI8	TLK1	S82	ochoa	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269\|PubMed:10523312, ECO:0000269\|PubMed:10588641, ECO:0000269\|PubMed:11314006, ECO:0000269\|PubMed:11470414, ECO:0000269\|PubMed:12660173, ECO:0000269\|PubMed:9427565}.
Q9UKI8	TLK1	S88	ochoa	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269\|PubMed:10523312, ECO:0000269\|PubMed:10588641, ECO:0000269\|PubMed:11314006, ECO:0000269\|PubMed:11470414, ECO:0000269\|PubMed:12660173, ECO:0000269\|PubMed:9427565}.
Q9UKX7	NUP50	S212	ochoa	Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)	Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250\|UniProtKB:Q9JIH2, ECO:0000269\|PubMed:20016008}.
Q9ULC3	RAB23	S188	ochoa	Ras-related protein Rab-23 (EC 3.6.5.2)	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. {ECO:0000269\|PubMed:22365972, ECO:0000269\|PubMed:22452336}.
Q9ULG1	INO80	S1495	ochoa	Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A)	ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269\|PubMed:16230350, ECO:0000269\|PubMed:16298340, ECO:0000269\|PubMed:17721549, ECO:0000269\|PubMed:20237820, ECO:0000269\|PubMed:20687897, ECO:0000269\|PubMed:20855601, ECO:0000269\|PubMed:21303910}.
Q9ULT8	HECTD1	S1517	ochoa	E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250\|UniProtKB:Q69ZR2, ECO:0000269\|PubMed:33711283}.
Q9UPQ0	LIMCH1	S201	ochoa	LIM and calponin homology domains-containing protein 1	Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269\|PubMed:28228547}.
Q9UQ35	SRRM2	S424	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	S846	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	S883	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	S901	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	S1032	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	S1110	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	S1550	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9Y2U5	MAP3K2	S300	ochoa	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)	Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269\|PubMed:10713157, ECO:0000269\|PubMed:16001074}.
Q9Y2U5	MAP3K2	S302	ochoa	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)	Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269\|PubMed:10713157, ECO:0000269\|PubMed:16001074}.
Q9Y2W1	THRAP3	Y228	ochoa	Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269\|PubMed:20123736, ECO:0000269\|PubMed:20932480, ECO:0000269\|PubMed:22424773, ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:24043798}.
Q9Y446	PKP3	S208	ochoa	Plakophilin-3	A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250\|UniProtKB:Q9QY23, ECO:0000269\|PubMed:20859650, ECO:0000269\|PubMed:24124604, ECO:0000269\|PubMed:25208567, ECO:0000269\|PubMed:25225333, ECO:0000269\|PubMed:34058472}.
Q9Y446	PKP3	S291	ochoa	Plakophilin-3	A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250\|UniProtKB:Q9QY23, ECO:0000269\|PubMed:20859650, ECO:0000269\|PubMed:24124604, ECO:0000269\|PubMed:25208567, ECO:0000269\|PubMed:25225333, ECO:0000269\|PubMed:34058472}.
Q9Y4E8	USP15	S233	ochoa	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269\|PubMed:16005295, ECO:0000269\|PubMed:17318178, ECO:0000269\|PubMed:19576224, ECO:0000269\|PubMed:19826004, ECO:0000269\|PubMed:21947082, ECO:0000269\|PubMed:22344298, ECO:0000269\|PubMed:24526689, ECO:0000269\|PubMed:24852371, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269\|PubMed:19553310}.
Q9Y4H2	IRS2	Y628	ochoa	Insulin receptor substrate 2 (IRS-2)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:15316008, ECO:0000269\|PubMed:19109239, ECO:0000269\|PubMed:24616100, ECO:0000269\|PubMed:25879670, ECO:0000269\|PubMed:32554797}.
Q9Y4H2	IRS2	S1162	ochoa	Insulin receptor substrate 2 (IRS-2)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:15316008, ECO:0000269\|PubMed:19109239, ECO:0000269\|PubMed:24616100, ECO:0000269\|PubMed:25879670, ECO:0000269\|PubMed:32554797}.
Q9Y5P4	CERT1	S132	ochoa\|psp	Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11)	Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269\|PubMed:14685229, ECO:0000269\|PubMed:17591919, ECO:0000269\|PubMed:18184806, ECO:0000269\|PubMed:20036255}.
Q9Y5P4	CERT1	S135	ochoa\|psp	Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11)	Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269\|PubMed:14685229, ECO:0000269\|PubMed:17591919, ECO:0000269\|PubMed:18184806, ECO:0000269\|PubMed:20036255}.
Q9Y5P4	CERT1	S141	ochoa	Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11)	Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269\|PubMed:14685229, ECO:0000269\|PubMed:17591919, ECO:0000269\|PubMed:18184806, ECO:0000269\|PubMed:20036255}.
Q9Y608	LRRFIP2	S320	ochoa	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)	May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269\|PubMed:15677333, ECO:0000269\|PubMed:19265123}.
Q9Y6X4	FAM169A	S358	ochoa	Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A)	None
Q9UPU5	USP24	S1360	Sugiyama	Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)	Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269\|PubMed:23159851, ECO:0000269\|PubMed:29695420}.
O14974	PPP1R12A	S894	Sugiyama	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269\|PubMed:18477460, ECO:0000269\|PubMed:19245366, ECO:0000269\|PubMed:20354225}.
Q8N6T3	ARFGAP1	T354	Sugiyama	ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)	GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}.
Q5SW79	CEP170	T870	Sugiyama	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q9BZL6	PRKD2	S189	Sugiyama	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250\|UniProtKB:Q8BZ03, ECO:0000269\|PubMed:14743217, ECO:0000269\|PubMed:15604256, ECO:0000269\|PubMed:16928771, ECO:0000269\|PubMed:17077180, ECO:0000269\|PubMed:17951978, ECO:0000269\|PubMed:17962809, ECO:0000269\|PubMed:18262756, ECO:0000269\|PubMed:19001381, ECO:0000269\|PubMed:19192391, ECO:0000269\|PubMed:23503467, ECO:0000269\|PubMed:28428613}.
Q5SW79	CEP170	S873	Sugiyama	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.

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reactome_id	name	p	-log10_p
R-HSA-2980766	Nuclear Envelope Breakdown	0.000009	5.069
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	0.000059	4.232
R-HSA-9924644	Developmental Lineages of the Mammary Gland	0.000269	3.570
R-HSA-9734767	Developmental Cell Lineages	0.000303	3.518
R-HSA-1640170	Cell Cycle	0.000405	3.392
R-HSA-68886	M Phase	0.000514	3.289
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells	0.000627	3.203
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	0.000696	3.158
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	0.000770	3.114
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	0.000770	3.114
R-HSA-69278	Cell Cycle, Mitotic	0.000737	3.133
R-HSA-68875	Mitotic Prophase	0.000724	3.140
R-HSA-1855170	IPs transport between nucleus and cytosol	0.000934	3.029
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.000934	3.029
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.000849	3.071
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.001025	2.989
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.001025	2.989
R-HSA-180746	Nuclear import of Rev protein	0.001122	2.950
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.001226	2.912
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.001416	2.849
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.001452	2.838
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.001706	2.768
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.001843	2.734
R-HSA-177243	Interactions of Rev with host cellular proteins	0.001843	2.734
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.001843	2.734
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.001575	2.803
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.001706	2.768
R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.002130	2.672
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.002051	2.688
R-HSA-4419969	Depolymerization of the Nuclear Lamina	0.002130	2.672
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.001989	2.701
R-HSA-1169408	ISG15 antiviral mechanism	0.002278	2.642
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.002835	2.547
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.003029	2.519
R-HSA-75153	Apoptotic execution phase	0.003029	2.519
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.003214	2.493
R-HSA-2995383	Initiation of Nuclear Envelope (NE) Reformation	0.003338	2.476
R-HSA-162582	Signal Transduction	0.003888	2.410
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	0.004460	2.351
R-HSA-68882	Mitotic Anaphase	0.004571	2.340
R-HSA-1221632	Meiotic synapsis	0.004653	2.332
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.004686	2.329
R-HSA-177929	Signaling by EGFR	0.005499	2.260
R-HSA-193648	NRAGE signals death through JNK	0.005499	2.260
R-HSA-1474165	Reproduction	0.005545	2.256
R-HSA-446107	Type I hemidesmosome assembly	0.006569	2.183
R-HSA-194441	Metabolism of non-coding RNA	0.006443	2.191
R-HSA-191859	snRNP Assembly	0.006443	2.191
R-HSA-9825895	Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ...	0.006569	2.183
R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.006827	2.166
R-HSA-1227990	Signaling by ERBB2 in Cancer	0.007371	2.132
R-HSA-428543	Inactivation of CDC42 and RAC1	0.007762	2.110
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.007762	2.110
R-HSA-168325	Viral Messenger RNA Synthesis	0.007128	2.147
R-HSA-6784531	tRNA processing in the nucleus	0.007488	2.126
R-HSA-182971	EGFR downregulation	0.007940	2.100
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	0.008638	2.064
R-HSA-68877	Mitotic Prometaphase	0.008942	2.049
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.009045	2.044
R-HSA-5578749	Transcriptional regulation by small RNAs	0.011758	1.930
R-HSA-1483249	Inositol phosphate metabolism	0.011919	1.924
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.012255	1.912
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.013414	1.872
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	0.014218	1.847
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.014943	1.826
R-HSA-416482	G alpha (12/13) signalling events	0.014943	1.826
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.017221	1.764
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.016598	1.780
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	0.016114	1.793
R-HSA-3371556	Cellular response to heat stress	0.016598	1.780
R-HSA-6802957	Oncogenic MAPK signaling	0.019290	1.715
R-HSA-1500620	Meiosis	0.019290	1.715
R-HSA-381038	XBP1(S) activates chaperone genes	0.020661	1.685
R-HSA-9673013	Diseases of Telomere Maintenance	0.021502	1.668
R-HSA-9670621	Defective Inhibition of DNA Recombination at Telomere	0.021502	1.668
R-HSA-9006821	Alternative Lengthening of Telomeres (ALT)	0.021502	1.668
R-HSA-9670615	Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	0.021502	1.668
R-HSA-9670613	Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	0.021502	1.668
R-HSA-9663199	Defective DNA double strand break response due to BRCA1 loss of function	0.021502	1.668
R-HSA-9699150	Defective DNA double strand break response due to BARD1 loss of function	0.021502	1.668
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.023727	1.625
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptor...	0.022307	1.652
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.024311	1.614
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.024311	1.614
R-HSA-1963642	PI3K events in ERBB2 signaling	0.024311	1.614
R-HSA-2028269	Signaling by Hippo	0.024311	1.614
R-HSA-9827857	Specification of primordial germ cells	0.024311	1.614
R-HSA-381070	IRE1alpha activates chaperones	0.025127	1.600
R-HSA-180292	GAB1 signalosome	0.026385	1.579
R-HSA-9613829	Chaperone Mediated Autophagy	0.026385	1.579
R-HSA-9609690	HCMV Early Events	0.030982	1.509
R-HSA-190827	Transport of connexins along the secretory pathway	0.032080	1.494
R-HSA-352238	Breakdown of the nuclear lamina	0.032080	1.494
R-HSA-190704	Oligomerization of connexins into connexons	0.032080	1.494
R-HSA-140875	Common Pathway of Fibrin Clot Formation	0.030740	1.512
R-HSA-9823730	Formation of definitive endoderm	0.030740	1.512
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	0.031393	1.503
R-HSA-193704	p75 NTR receptor-mediated signalling	0.032841	1.484
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.033016	1.481
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.033016	1.481
R-HSA-70171	Glycolysis	0.033775	1.471
R-HSA-9665230	Drug resistance in ERBB2 KD mutants	0.042544	1.371
R-HSA-9652282	Drug-mediated inhibition of ERBB2 signaling	0.042544	1.371
R-HSA-8951911	RUNX3 regulates RUNX1-mediated transcription	0.042544	1.371
R-HSA-9665737	Drug resistance in ERBB2 TMD/JMD mutants	0.042544	1.371
R-HSA-9665249	Resistance of ERBB2 KD mutants to afatinib	0.042544	1.371
R-HSA-9665233	Resistance of ERBB2 KD mutants to trastuzumab	0.042544	1.371
R-HSA-3814836	Glycogen storage disease type XV (GYG1)	0.042544	1.371
R-HSA-9665246	Resistance of ERBB2 KD mutants to neratinib	0.042544	1.371
R-HSA-9665250	Resistance of ERBB2 KD mutants to AEE788	0.042544	1.371
R-HSA-9665247	Resistance of ERBB2 KD mutants to osimertinib	0.042544	1.371
R-HSA-9665251	Resistance of ERBB2 KD mutants to lapatinib	0.042544	1.371
R-HSA-9665244	Resistance of ERBB2 KD mutants to sapitinib	0.042544	1.371
R-HSA-3828062	Glycogen storage disease type 0 (muscle GYS1)	0.042544	1.371
R-HSA-9665245	Resistance of ERBB2 KD mutants to tesevatinib	0.042544	1.371
R-HSA-1227986	Signaling by ERBB2	0.038708	1.412
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in ...	0.037759	1.423
R-HSA-3000170	Syndecan interactions	0.040222	1.396
R-HSA-1266738	Developmental Biology	0.035023	1.456
R-HSA-9707616	Heme signaling	0.041578	1.381
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.035688	1.447
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.040727	1.390
R-HSA-211000	Gene Silencing by RNA	0.041797	1.379
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.042744	1.369
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.042744	1.369
R-HSA-162587	HIV Life Cycle	0.043297	1.364
R-HSA-1643713	Signaling by EGFR in Cancer	0.047960	1.319
R-HSA-9022699	MECP2 regulates neuronal receptors and channels	0.047960	1.319
R-HSA-2467813	Separation of Sister Chromatids	0.049667	1.304
R-HSA-8865999	MET activates PTPN11	0.052896	1.277
R-HSA-9705683	SARS-CoV-2-host interactions	0.054912	1.260
R-HSA-70326	Glucose metabolism	0.055682	1.254
R-HSA-9006335	Signaling by Erythropoietin	0.056190	1.250
R-HSA-8863795	Downregulation of ERBB2 signaling	0.059036	1.229
R-HSA-191650	Regulation of gap junction activity	0.063136	1.200
R-HSA-1251932	PLCG1 events in ERBB2 signaling	0.063136	1.200
R-HSA-8952158	RUNX3 regulates BCL2L11 (BIM) transcription	0.063136	1.200
R-HSA-74713	IRS activation	0.073267	1.135
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.083288	1.079
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.083288	1.079
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.083288	1.079
R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.093202	1.031
R-HSA-9027283	Erythropoietin activates STAT5	0.093202	1.031
R-HSA-8949275	RUNX3 Regulates Immune Response and Cell Migration	0.103009	0.987
R-HSA-8851907	MET activates PI3K/AKT signaling	0.103009	0.987
R-HSA-9732724	IFNG signaling activates MAPKs	0.103009	0.987
R-HSA-112412	SOS-mediated signalling	0.103009	0.987
R-HSA-2470946	Cohesin Loading onto Chromatin	0.103009	0.987
R-HSA-9726840	SHOC2 M1731 mutant abolishes MRAS complex function	0.103009	0.987
R-HSA-212718	EGFR interacts with phospholipase C-gamma	0.112710	0.948
R-HSA-3785653	Myoclonic epilepsy of Lafora	0.112710	0.948
R-HSA-9028335	Activated NTRK2 signals through PI3K	0.112710	0.948
R-HSA-8875656	MET receptor recycling	0.112710	0.948
R-HSA-9660537	Signaling by MRAS-complex mutants	0.112710	0.948
R-HSA-196025	Formation of annular gap junctions	0.112710	0.948
R-HSA-9726842	Gain-of-function MRAS complexes activate RAF signaling	0.112710	0.948
R-HSA-190873	Gap junction degradation	0.122308	0.913
R-HSA-201688	WNT mediated activation of DVL	0.122308	0.913
R-HSA-8875555	MET activates RAP1 and RAC1	0.131802	0.880
R-HSA-9027277	Erythropoietin activates Phospholipase C gamma (PLCG)	0.131802	0.880
R-HSA-68952	DNA replication initiation	0.131802	0.880
R-HSA-2514853	Condensation of Prometaphase Chromosomes	0.150484	0.823
R-HSA-8951936	RUNX3 regulates p14-ARF	0.159675	0.797
R-HSA-69091	Polymerase switching	0.159675	0.797
R-HSA-69109	Leading Strand Synthesis	0.159675	0.797
R-HSA-9820865	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	0.159675	0.797
R-HSA-69166	Removal of the Flap Intermediate	0.177762	0.750
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.177762	0.750
R-HSA-9027284	Erythropoietin activates RAS	0.186659	0.729
R-HSA-180336	SHC1 events in EGFR signaling	0.186659	0.729
R-HSA-6785631	ERBB2 Regulates Cell Motility	0.186659	0.729
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.195461	0.709
R-HSA-9927426	Developmental Lineage of Mammary Gland Alveolar Cells	0.073969	1.131
R-HSA-8964616	G beta:gamma signalling through CDC42	0.204168	0.690
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.204168	0.690
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.212781	0.672
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	0.212781	0.672
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	0.096615	1.015
R-HSA-5654710	PI-3K cascade:FGFR3	0.229731	0.639
R-HSA-9709603	Impaired BRCA2 binding to PALB2	0.229731	0.639
R-HSA-9656223	Signaling by RAF1 mutants	0.099995	1.000
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	0.103407	0.985
R-HSA-5654720	PI-3K cascade:FGFR4	0.238069	0.623
R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	0.238069	0.623
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	0.238069	0.623
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.238069	0.623
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.238069	0.623
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	0.238069	0.623
R-HSA-9649948	Signaling downstream of RAS mutants	0.117362	0.930
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.083768	1.077
R-HSA-141424	Amplification of signal from the kinetochores	0.083768	1.077
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.154039	0.812
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	0.204350	0.690
R-HSA-72163	mRNA Splicing - Major Pathway	0.202727	0.693
R-HSA-69183	Processive synthesis on the lagging strand	0.186659	0.729
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.117362	0.930
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.117362	0.930
R-HSA-69618	Mitotic Spindle Checkpoint	0.121281	0.916
R-HSA-5674135	MAP2K and MAPK activation	0.099995	1.000
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.228158	0.642
R-HSA-5696398	Nucleotide Excision Repair	0.135771	0.867
R-HSA-198203	PI3K/AKT activation	0.131802	0.880
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.070893	1.149
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.079739	1.098
R-HSA-6802949	Signaling by RAS mutants	0.117362	0.930
R-HSA-173107	Binding and entry of HIV virion	0.131802	0.880
R-HSA-9796292	Formation of axial mesoderm	0.168768	0.773
R-HSA-174430	Telomere C-strand synthesis initiation	0.186659	0.729
R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.159675	0.797
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.073267	1.135
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	0.131802	0.880
R-HSA-179812	GRB2 events in EGFR signaling	0.159675	0.797
R-HSA-9664420	Killing mechanisms	0.195461	0.709
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	0.195461	0.709
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anapha...	0.204168	0.690
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.083446	1.079
R-HSA-190872	Transport of connexons to the plasma membrane	0.221302	0.655
R-HSA-72172	mRNA Splicing	0.227640	0.643
R-HSA-8937144	Aryl hydrocarbon receptor signalling	0.083288	1.079
R-HSA-8951430	RUNX3 regulates WNT signaling	0.103009	0.987
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.111961	0.951
R-HSA-8856828	Clathrin-mediated endocytosis	0.099782	1.001
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P...	0.122308	0.913
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.177762	0.750
R-HSA-2179392	EGFR Transactivation by Gastrin	0.131802	0.880
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.150484	0.823
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	0.159675	0.797
R-HSA-9933947	Formation of the non-canonical BAF (ncBAF) complex	0.168768	0.773
R-HSA-9603798	Class I peroxisomal membrane protein import	0.195461	0.709
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.204168	0.690
R-HSA-3322077	Glycogen synthesis	0.238069	0.623
R-HSA-2428928	IRS-related events triggered by IGF1R	0.173118	0.762
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.105162	0.978
R-HSA-5693532	DNA Double-Strand Break Repair	0.117243	0.931
R-HSA-3928664	Ephrin signaling	0.221302	0.655
R-HSA-112399	IRS-mediated signalling	0.157821	0.802
R-HSA-74749	Signal attenuation	0.131802	0.880
R-HSA-9937080	Developmental Lineage of Multipotent Pancreatic Progenitor Cells	0.064872	1.188
R-HSA-3229121	Glycogen storage diseases	0.212781	0.672
R-HSA-74751	Insulin receptor signalling cascade	0.184743	0.733
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	0.115440	0.938
R-HSA-9856532	Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	0.229731	0.639
R-HSA-2428924	IGF1R signaling cascade	0.184743	0.733
R-HSA-5674499	Negative feedback regulation of MAPK pathway	0.083288	1.079
R-HSA-9619229	Activation of RAC1 downstream of NMDARs	0.122308	0.913
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.150484	0.823
R-HSA-399954	Sema3A PAK dependent Axon repulsion	0.186659	0.729
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.229731	0.639
R-HSA-6809371	Formation of the cornified envelope	0.190539	0.720
R-HSA-9843745	Adipogenesis	0.215523	0.667
R-HSA-9609646	HCMV Infection	0.075748	1.121
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.188643	0.724
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.131634	0.881
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	0.238069	0.623
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.187811	0.726
R-HSA-73894	DNA Repair	0.122130	0.913
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	0.063136	1.200
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.103009	0.987
R-HSA-9820962	Assembly and release of respiratory syncytial virus (RSV) virions	0.131802	0.880
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.168768	0.773
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.089958	1.046
R-HSA-113510	E2F mediated regulation of DNA replication	0.229731	0.639
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	0.139100	0.857
R-HSA-201681	TCF dependent signaling in response to WNT	0.070754	1.150
R-HSA-430116	GP1b-IX-V activation signalling	0.122308	0.913
R-HSA-844456	The NLRP3 inflammasome	0.229731	0.639
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.169270	0.771
R-HSA-8853659	RET signaling	0.080247	1.096
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen...	0.083288	1.079
R-HSA-5336415	Uptake and function of diphtheria toxin	0.103009	0.987
R-HSA-9834752	Respiratory syncytial virus genome replication	0.122308	0.913
R-HSA-5655291	Signaling by FGFR4 in disease	0.177762	0.750
R-HSA-9933937	Formation of the canonical BAF (cBAF) complex	0.177762	0.750
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	0.186659	0.729
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.186659	0.729
R-HSA-5620916	VxPx cargo-targeting to cilium	0.238069	0.623
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.145747	0.836
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.209909	0.678
R-HSA-9942503	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	0.195461	0.709
R-HSA-9945266	Differentiation of T cells	0.195461	0.709
R-HSA-5689603	UCH proteinases	0.232147	0.634
R-HSA-9933939	Formation of the polybromo-BAF (pBAF) complex	0.177762	0.750
R-HSA-109704	PI3K Cascade	0.131757	0.880
R-HSA-392517	Rap1 signalling	0.229731	0.639
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.120886	0.918
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.130876	0.883
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	0.220196	0.657
R-HSA-8852135	Protein ubiquitination	0.228158	0.642
R-HSA-2586552	Signaling by Leptin	0.131802	0.880
R-HSA-9610379	HCMV Late Events	0.124578	0.905
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	0.112710	0.948
R-HSA-446353	Cell-extracellular matrix interactions	0.186659	0.729
R-HSA-373755	Semaphorin interactions	0.180855	0.743
R-HSA-162909	Host Interactions of HIV factors	0.064796	1.188
R-HSA-445144	Signal transduction by L1	0.238069	0.623
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.106851	0.971
R-HSA-5688426	Deubiquitination	0.181352	0.741
R-HSA-168255	Influenza Infection	0.170230	0.769
R-HSA-376176	Signaling by ROBO receptors	0.223052	0.652
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.080247	1.096
R-HSA-9018519	Estrogen-dependent gene expression	0.232548	0.633
R-HSA-162906	HIV Infection	0.133253	0.875
R-HSA-8953897	Cellular responses to stimuli	0.200643	0.698
R-HSA-9675108	Nervous system development	0.066084	1.180
R-HSA-422475	Axon guidance	0.090934	1.041
R-HSA-9909396	Circadian clock	0.218342	0.661
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.073860	1.132
R-HSA-8953750	Transcriptional Regulation by E2F6	0.089958	1.046
R-HSA-194068	Bile acid and bile salt metabolism	0.148278	0.829
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.228158	0.642
R-HSA-73893	DNA Damage Bypass	0.128121	0.892
R-HSA-1236394	Signaling by ERBB4	0.224174	0.649
R-HSA-1592230	Mitochondrial biogenesis	0.171668	0.765
R-HSA-1834941	STING mediated induction of host immune responses	0.229731	0.639
R-HSA-192105	Synthesis of bile acids and bile salts	0.118925	0.925
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.157821	0.802
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.174330	0.759
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.110326	0.957
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.198289	0.703
R-HSA-109581	Apoptosis	0.134014	0.873
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.165438	0.781
R-HSA-5357801	Programmed Cell Death	0.229944	0.638
R-HSA-162599	Late Phase of HIV Life Cycle	0.098107	1.008
R-HSA-9694516	SARS-CoV-2 Infection	0.109307	0.961
R-HSA-381119	Unfolded Protein Response (UPR)	0.091544	1.038
R-HSA-72306	tRNA processing	0.151704	0.819
R-HSA-5619102	SLC transporter disorders	0.143733	0.842
R-HSA-73887	Death Receptor Signaling	0.119058	0.924
R-HSA-216083	Integrin cell surface interactions	0.240137	0.620
R-HSA-2262752	Cellular responses to stress	0.240721	0.618
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.246318	0.609
R-HSA-5602498	MyD88 deficiency (TLR2/4)	0.246318	0.609
R-HSA-69186	Lagging Strand Synthesis	0.246318	0.609
R-HSA-202040	G-protein activation	0.246318	0.609
R-HSA-162594	Early Phase of HIV Life Cycle	0.246318	0.609
R-HSA-9819196	Zygotic genome activation (ZGA)	0.246318	0.609
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	0.254477	0.594
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.254477	0.594
R-HSA-5654689	PI-3K cascade:FGFR1	0.262549	0.581
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	0.262549	0.581
R-HSA-166208	mTORC1-mediated signalling	0.262549	0.581
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.262549	0.581
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.264171	0.578
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.264171	0.578
R-HSA-195721	Signaling by WNT	0.265221	0.576
R-HSA-69242	S Phase	0.270178	0.568
R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.270534	0.568
R-HSA-982772	Growth hormone receptor signaling	0.270534	0.568
R-HSA-9758941	Gastrulation	0.273104	0.564
R-HSA-9856651	MITF-M-dependent gene expression	0.276034	0.559
R-HSA-913531	Interferon Signaling	0.277161	0.557
R-HSA-3700989	Transcriptional Regulation by TP53	0.278333	0.555
R-HSA-429947	Deadenylation of mRNA	0.278433	0.555
R-HSA-5621575	CD209 (DC-SIGN) signaling	0.278433	0.555
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis...	0.278433	0.555
R-HSA-8863678	Neurodegenerative Diseases	0.278433	0.555
R-HSA-597592	Post-translational protein modification	0.281962	0.550
R-HSA-9645723	Diseases of programmed cell death	0.284212	0.546
R-HSA-5654695	PI-3K cascade:FGFR2	0.286247	0.543
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD...	0.286247	0.543
R-HSA-9932451	SWI/SNF chromatin remodelers	0.286247	0.543
R-HSA-9932444	ATP-dependent chromatin remodelers	0.286247	0.543
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.286247	0.543
R-HSA-400685	Sema4D in semaphorin signaling	0.286247	0.543
R-HSA-3000157	Laminin interactions	0.286247	0.543
R-HSA-1266695	Interleukin-7 signaling	0.286247	0.543
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	0.293977	0.532
R-HSA-5689901	Metalloprotease DUBs	0.293977	0.532
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	0.293977	0.532
R-HSA-8986944	Transcriptional Regulation by MECP2	0.296216	0.528
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.301623	0.521
R-HSA-5655332	Signaling by FGFR3 in disease	0.301623	0.521
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.301623	0.521
R-HSA-264876	Insulin processing	0.301623	0.521
R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.301623	0.521
R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	0.301623	0.521
R-HSA-74752	Signaling by Insulin receptor	0.304203	0.517
R-HSA-199991	Membrane Trafficking	0.304651	0.516
R-HSA-8939211	ESR-mediated signaling	0.306119	0.514
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.309188	0.510
R-HSA-622312	Inflammasomes	0.309188	0.510
R-HSA-1852241	Organelle biogenesis and maintenance	0.311169	0.507
R-HSA-1474290	Collagen formation	0.312174	0.506
R-HSA-9615710	Late endosomal microautophagy	0.316670	0.499
R-HSA-9709570	Impaired BRCA2 binding to RAD51	0.316670	0.499
R-HSA-5654708	Downstream signaling of activated FGFR3	0.316670	0.499
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.324072	0.489
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	0.324072	0.489
R-HSA-5654716	Downstream signaling of activated FGFR4	0.324072	0.489
R-HSA-68962	Activation of the pre-replicative complex	0.324072	0.489
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	0.324072	0.489
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.324094	0.489
R-HSA-6807878	COPI-mediated anterograde transport	0.324094	0.489
R-HSA-8878159	Transcriptional regulation by RUNX3	0.328056	0.484
R-HSA-157579	Telomere Maintenance	0.328056	0.484
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.328056	0.484
R-HSA-5619115	Disorders of transmembrane transporters	0.330552	0.481
R-HSA-2129379	Molecules associated with elastic fibres	0.331395	0.480
R-HSA-9820960	Respiratory syncytial virus (RSV) attachment and entry	0.331395	0.480
R-HSA-69190	DNA strand elongation	0.338638	0.470
R-HSA-9675126	Diseases of mitotic cell cycle	0.338638	0.470
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.345804	0.461
R-HSA-354192	Integrin signaling	0.345804	0.461
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.345804	0.461
R-HSA-397795	G-protein beta:gamma signalling	0.345804	0.461
R-HSA-9733709	Cardiogenesis	0.345804	0.461
R-HSA-159418	Recycling of bile acids and salts	0.345804	0.461
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.345804	0.461
R-HSA-5689880	Ub-specific processing proteases	0.346878	0.460
R-HSA-390522	Striated Muscle Contraction	0.352892	0.452
R-HSA-5693537	Resolution of D-Loop Structures	0.352892	0.452
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	0.352892	0.452
R-HSA-69620	Cell Cycle Checkpoints	0.357548	0.447
R-HSA-5696400	Dual Incision in GG-NER	0.359904	0.444
R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	0.359904	0.444
R-HSA-5673000	RAF activation	0.359904	0.444
R-HSA-190861	Gap junction assembly	0.359904	0.444
R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	0.359904	0.444
R-HSA-5686938	Regulation of TLR by endogenous ligand	0.359904	0.444
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	0.359904	0.444
R-HSA-5654696	Downstream signaling of activated FGFR2	0.366841	0.436
R-HSA-5654687	Downstream signaling of activated FGFR1	0.366841	0.436
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.366841	0.436
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ...	0.366841	0.436
R-HSA-3371511	HSF1 activation	0.373702	0.427
R-HSA-8941326	RUNX2 regulates bone development	0.373702	0.427
R-HSA-6804757	Regulation of TP53 Degradation	0.373702	0.427
R-HSA-1236975	Antigen processing-Cross presentation	0.375032	0.426
R-HSA-2672351	Stimuli-sensing channels	0.375032	0.426
R-HSA-4641258	Degradation of DVL	0.380490	0.420
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.380490	0.420
R-HSA-69275	G2/M Transition	0.385131	0.414
R-HSA-375276	Peptide ligand-binding receptors	0.385131	0.414
R-HSA-8875878	MET promotes cell motility	0.387204	0.412
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.387204	0.412
R-HSA-1566948	Elastic fibre formation	0.387204	0.412
R-HSA-453274	Mitotic G2-G2/M phases	0.390978	0.408
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.393847	0.405
R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translat...	0.393847	0.405
R-HSA-9855142	Cellular responses to mechanical stimuli	0.398031	0.400
R-HSA-8941858	Regulation of RUNX3 expression and activity	0.400417	0.397
R-HSA-9670095	Inhibition of DNA recombination at telomere	0.400417	0.397
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.400417	0.397
R-HSA-8982491	Glycogen metabolism	0.400417	0.397
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.400417	0.397
R-HSA-5260271	Diseases of Immune System	0.400417	0.397
R-HSA-3371568	Attenuation phase	0.400417	0.397
R-HSA-9646399	Aggrephagy	0.400417	0.397
R-HSA-1251985	Nuclear signaling by ERBB4	0.400417	0.397
R-HSA-446728	Cell junction organization	0.406537	0.391
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.406917	0.390
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.406917	0.390
R-HSA-9694548	Maturation of spike protein	0.406917	0.390
R-HSA-5675221	Negative regulation of MAPK pathway	0.413347	0.384
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.413347	0.384
R-HSA-5655302	Signaling by FGFR1 in disease	0.413347	0.384
R-HSA-165159	MTOR signalling	0.419707	0.377
R-HSA-5693538	Homology Directed Repair	0.420634	0.376
R-HSA-9710421	Defective pyroptosis	0.425999	0.371
R-HSA-5654743	Signaling by FGFR4	0.425999	0.371
R-HSA-73886	Chromosome Maintenance	0.431774	0.365
R-HSA-190828	Gap junction trafficking	0.432223	0.364
R-HSA-5673001	RAF/MAP kinase cascade	0.433214	0.363
R-HSA-9679506	SARS-CoV Infections	0.436081	0.360
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.438380	0.358
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.438380	0.358
R-HSA-5654741	Signaling by FGFR3	0.438380	0.358
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.439138	0.357
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.444470	0.352
R-HSA-9675135	Diseases of DNA repair	0.444470	0.352
R-HSA-9660826	Purinergic signaling in leishmaniasis infection	0.444470	0.352
R-HSA-9664424	Cell recruitment (pro-inflammatory response)	0.444470	0.352
R-HSA-6805567	Keratinization	0.445701	0.351
R-HSA-5684996	MAPK1/MAPK3 signaling	0.450026	0.347
R-HSA-157858	Gap junction trafficking and regulation	0.462351	0.335
R-HSA-380108	Chemokine receptors bind chemokines	0.462351	0.335
R-HSA-9730414	MITF-M-regulated melanocyte development	0.465391	0.332
R-HSA-5655253	Signaling by FGFR2 in disease	0.468183	0.330
R-HSA-3371571	HSF1-dependent transactivation	0.473952	0.324
R-HSA-912446	Meiotic recombination	0.473952	0.324
R-HSA-8856688	Golgi-to-ER retrograde transport	0.478681	0.320
R-HSA-72187	mRNA 3'-end processing	0.479659	0.319
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.479659	0.319
R-HSA-6794361	Neurexins and neuroligins	0.479659	0.319
R-HSA-5339562	Uptake and actions of bacterial toxins	0.479659	0.319
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	0.485304	0.314
R-HSA-445355	Smooth Muscle Contraction	0.485304	0.314
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.485304	0.314
R-HSA-8951664	Neddylation	0.487515	0.312
R-HSA-72649	Translation initiation complex formation	0.490888	0.309
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	0.496413	0.304
R-HSA-9012852	Signaling by NOTCH3	0.496413	0.304
R-HSA-1500931	Cell-Cell communication	0.497123	0.304
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	0.499528	0.301
R-HSA-74160	Gene expression (Transcription)	0.500010	0.301
R-HSA-72702	Ribosomal scanning and start codon recognition	0.501877	0.299
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.501877	0.299
R-HSA-5654736	Signaling by FGFR1	0.501877	0.299
R-HSA-6782135	Dual incision in TC-NER	0.512630	0.290
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	0.512630	0.290
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.512630	0.290
R-HSA-9033241	Peroxisomal protein import	0.517920	0.286
R-HSA-429914	Deadenylation-dependent mRNA decay	0.517920	0.286
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.517920	0.286
R-HSA-180786	Extension of Telomeres	0.517920	0.286
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	0.523152	0.281
R-HSA-8873719	RAB geranylgeranylation	0.523152	0.281
R-HSA-73856	RNA Polymerase II Transcription Termination	0.528328	0.277
R-HSA-211976	Endogenous sterols	0.528328	0.277
R-HSA-1474244	Extracellular matrix organization	0.531310	0.275
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	0.533448	0.273
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	0.533448	0.273
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.533448	0.273
R-HSA-199977	ER to Golgi Anterograde Transport	0.536339	0.271
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.536485	0.270
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	0.538513	0.269
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.538513	0.269
R-HSA-8848021	Signaling by PTK6	0.538513	0.269
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.538513	0.269
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.538513	0.269
R-HSA-166520	Signaling by NTRKs	0.539593	0.268
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	0.543523	0.265
R-HSA-5653656	Vesicle-mediated transport	0.549081	0.260
R-HSA-8854518	AURKA Activation by TPX2	0.553382	0.257
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	0.553382	0.257
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.558232	0.253
R-HSA-5693606	DNA Double Strand Break Response	0.558232	0.253
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.558232	0.253
R-HSA-1989781	PPARA activates gene expression	0.561928	0.250
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	0.563029	0.249
R-HSA-9612973	Autophagy	0.565056	0.248
R-HSA-5683057	MAPK family signaling cascades	0.566492	0.247
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.568167	0.246
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.572469	0.242
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	0.577112	0.239
R-HSA-453276	Regulation of mitotic cell cycle	0.577112	0.239
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.577112	0.239
R-HSA-3000178	ECM proteoglycans	0.577112	0.239
R-HSA-5633007	Regulation of TP53 Activity	0.577405	0.239
R-HSA-9006936	Signaling by TGFB family members	0.577405	0.239
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.581706	0.235
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.586249	0.232
R-HSA-5663084	Diseases of carbohydrate metabolism	0.586249	0.232
R-HSA-8953854	Metabolism of RNA	0.588031	0.231
R-HSA-69473	G2/M DNA damage checkpoint	0.590744	0.229
R-HSA-1226099	Signaling by FGFR in disease	0.590744	0.229
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	0.592292	0.227
R-HSA-380287	Centrosome maturation	0.595190	0.225
R-HSA-9006931	Signaling by Nuclear Receptors	0.600193	0.222
R-HSA-9694635	Translation of Structural Proteins	0.603939	0.219
R-HSA-4086400	PCP/CE pathway	0.608243	0.216
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.612500	0.213
R-HSA-6806834	Signaling by MET	0.616711	0.210
R-HSA-5654738	Signaling by FGFR2	0.616711	0.210
R-HSA-5693607	Processing of DNA double-strand break ends	0.620877	0.207
R-HSA-977225	Amyloid fiber formation	0.620877	0.207
R-HSA-76002	Platelet activation, signaling and aggregation	0.621367	0.207
R-HSA-9707564	Cytoprotection by HMOX1	0.629073	0.201
R-HSA-6794362	Protein-protein interactions at synapses	0.637094	0.196
R-HSA-388396	GPCR downstream signalling	0.637512	0.196
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.644942	0.190
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.644942	0.190
R-HSA-438064	Post NMDA receptor activation events	0.648802	0.188
R-HSA-1280215	Cytokine Signaling in Immune system	0.649368	0.188
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.652621	0.185
R-HSA-9663891	Selective autophagy	0.652621	0.185
R-HSA-1236974	ER-Phagosome pathway	0.656399	0.183
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.660135	0.180
R-HSA-73884	Base Excision Repair	0.660135	0.180
R-HSA-983712	Ion channel transport	0.661854	0.179
R-HSA-5617833	Cilium Assembly	0.664423	0.178
R-HSA-168898	Toll-like Receptor Cascades	0.666976	0.176
R-HSA-1257604	PIP3 activates AKT signaling	0.667414	0.176
R-HSA-2682334	EPH-Ephrin signaling	0.671104	0.173
R-HSA-9772573	Late SARS-CoV-2 Infection Events	0.671104	0.173
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.681721	0.166
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.689257	0.162
R-HSA-428157	Sphingolipid metabolism	0.691656	0.160
R-HSA-948021	Transport to the Golgi and subsequent modification	0.694040	0.159
R-HSA-8957275	Post-translational protein phosphorylation	0.695349	0.158
R-HSA-190236	Signaling by FGFR	0.695349	0.158
R-HSA-3214847	HATs acetylate histones	0.698665	0.156
R-HSA-9009391	Extra-nuclear estrogen signaling	0.705188	0.152
R-HSA-9842860	Regulation of endogenous retroelements	0.708397	0.150
R-HSA-2559580	Oxidative Stress Induced Senescence	0.708397	0.150
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	0.708397	0.150
R-HSA-1483255	PI Metabolism	0.708397	0.150
R-HSA-111885	Opioid Signalling	0.714711	0.146
R-HSA-9860931	Response of endothelial cells to shear stress	0.714711	0.146
R-HSA-397014	Muscle contraction	0.719273	0.143
R-HSA-8957322	Metabolism of steroids	0.724131	0.140
R-HSA-69239	Synthesis of DNA	0.726933	0.139
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.726933	0.139
R-HSA-9700206	Signaling by ALK in cancer	0.726933	0.139
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	0.729907	0.137
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	0.729907	0.137
R-HSA-69002	DNA Replication Pre-Initiation	0.732848	0.135
R-HSA-372790	Signaling by GPCR	0.742950	0.129
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.747083	0.127
R-HSA-8878171	Transcriptional regulation by RUNX1	0.748848	0.126
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	0.749839	0.125
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.752564	0.123
R-HSA-9006925	Intracellular signaling by second messengers	0.755396	0.122
R-HSA-72613	Eukaryotic Translation Initiation	0.757926	0.120
R-HSA-72737	Cap-dependent Translation Initiation	0.757926	0.120
R-HSA-373760	L1CAM interactions	0.757926	0.120
R-HSA-2980736	Peptide hormone metabolism	0.760564	0.119
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.765754	0.116
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.765754	0.116
R-HSA-8878166	Transcriptional regulation by RUNX2	0.765754	0.116
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.773330	0.112
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.773330	0.112
R-HSA-73857	RNA Polymerase II Transcription	0.775113	0.111
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.783054	0.106
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.783054	0.106
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.783054	0.106
R-HSA-69206	G1/S Transition	0.783054	0.106
R-HSA-69481	G2/M Checkpoints	0.787759	0.104
R-HSA-114608	Platelet degranulation	0.787759	0.104
R-HSA-187037	Signaling by NTRK1 (TRKA)	0.790074	0.102
R-HSA-4839726	Chromatin organization	0.791649	0.101
R-HSA-392499	Metabolism of proteins	0.793205	0.101
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.803443	0.095
R-HSA-9824446	Viral Infection Pathways	0.806583	0.093
R-HSA-3858494	Beta-catenin independent WNT signaling	0.811881	0.091
R-HSA-416476	G alpha (q) signalling events	0.815995	0.088
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.817338	0.088
R-HSA-212436	Generic Transcription Pathway	0.818766	0.087
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.821925	0.085
R-HSA-1632852	Macroautophagy	0.821925	0.085
R-HSA-9711123	Cellular response to chemical stress	0.822046	0.085
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.831195	0.080
R-HSA-453279	Mitotic G1 phase and G1/S transition	0.833276	0.079
R-HSA-449147	Signaling by Interleukins	0.834423	0.079
R-HSA-211945	Phase I - Functionalization of compounds	0.836403	0.078
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.836897	0.077
R-HSA-9679191	Potential therapeutics for SARS	0.840440	0.075
R-HSA-9824443	Parasitic Infection Pathways	0.840502	0.075
R-HSA-9658195	Leishmania infection	0.840502	0.075
R-HSA-9755511	KEAP1-NFE2L2 pathway	0.842183	0.075
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	0.843907	0.074
R-HSA-9609507	Protein localization	0.845612	0.073
R-HSA-69306	DNA Replication	0.845612	0.073
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.847299	0.072
R-HSA-877300	Interferon gamma signaling	0.855461	0.068
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.867627	0.062
R-HSA-5621481	C-type lectin receptors (CLRs)	0.874708	0.058
R-HSA-9909648	Regulation of PD-L1(CD274) expression	0.876079	0.057
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.878775	0.056
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.880101	0.055
R-HSA-2559583	Cellular Senescence	0.886518	0.052
R-HSA-212165	Epigenetic regulation of gene expression	0.888910	0.051
R-HSA-6798695	Neutrophil degranulation	0.894384	0.048
R-HSA-389948	Co-inhibition by PD-1	0.908948	0.041
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.921103	0.036
R-HSA-418990	Adherens junctions interactions	0.926154	0.033
R-HSA-3247509	Chromatin modifying enzymes	0.938108	0.028
R-HSA-157118	Signaling by NOTCH	0.942076	0.026
R-HSA-418594	G alpha (i) signalling events	0.948188	0.023
R-HSA-421270	Cell-cell junction organization	0.948705	0.023
R-HSA-388841	Regulation of T cell activation by CD28 family	0.951464	0.022
R-HSA-446203	Asparagine N-linked glycosylation	0.954874	0.020
R-HSA-500792	GPCR ligand binding	0.963421	0.016
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.963599	0.016
R-HSA-1483257	Phospholipid metabolism	0.968482	0.014
R-HSA-112316	Neuronal System	0.970630	0.013
R-HSA-1643685	Disease	0.974345	0.011
R-HSA-112315	Transmission across Chemical Synapses	0.976898	0.010
R-HSA-109582	Hemostasis	0.977178	0.010
R-HSA-5663205	Infectious disease	0.982601	0.008
R-HSA-211859	Biological oxidations	0.982602	0.008
R-HSA-168256	Immune System	0.988263	0.005
R-HSA-9824439	Bacterial Infection Pathways	0.989160	0.005
R-HSA-1280218	Adaptive Immune System	0.991617	0.004
R-HSA-168249	Innate Immune System	0.992640	0.003
R-HSA-5668914	Diseases of metabolism	0.992829	0.003
R-HSA-72766	Translation	0.992987	0.003
R-HSA-556833	Metabolism of lipids	0.997824	0.001
R-HSA-382551	Transport of small molecules	0.999835	0.000
R-HSA-9752946	Expression and translocation of olfactory receptors	0.999884	0.000
R-HSA-381753	Olfactory Signaling Pathway	0.999951	0.000
R-HSA-9709957	Sensory Perception	0.999999	0.000
R-HSA-1430728	Metabolism	1.000000	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
COT	0.884	0.326	2	0.881
CLK3	0.875	0.261	1	0.802
GRK1	0.874	0.361	-2	0.822
MOS	0.871	0.290	1	0.813
KIS	0.869	0.235	1	0.702
MTOR	0.866	0.130	1	0.763
IKKB	0.864	0.100	-2	0.745
GRK7	0.862	0.299	1	0.743
CDC7	0.862	0.095	1	0.790
PIM3	0.859	0.078	-3	0.811
GRK6	0.858	0.229	1	0.811
GRK5	0.858	0.143	-3	0.898
CDK1	0.857	0.195	1	0.674
PRPK	0.857	-0.043	-1	0.826
BMPR1B	0.856	0.267	1	0.799
NDR2	0.856	0.071	-3	0.814
RAF1	0.856	0.020	1	0.811
CAMK2G	0.855	0.048	2	0.823
DSTYK	0.854	0.061	2	0.901
NLK	0.854	0.072	1	0.828
ATR	0.854	0.033	1	0.776
IKKA	0.854	0.109	-2	0.740
MLK1	0.853	0.082	2	0.833
SKMLCK	0.852	0.091	-2	0.865
CK1E	0.852	0.278	-3	0.734
SRPK1	0.852	0.105	-3	0.716
HIPK4	0.850	0.117	1	0.809
PDHK4	0.850	-0.153	1	0.817
CDKL1	0.849	0.044	-3	0.770
GRK4	0.849	0.119	-2	0.829
ERK5	0.849	0.038	1	0.793
MST4	0.849	0.053	2	0.878
CAMK1B	0.849	-0.021	-3	0.821
BMPR2	0.848	-0.089	-2	0.837
IKKE	0.848	-0.038	1	0.715
TBK1	0.848	-0.059	1	0.716
DLK	0.848	0.117	1	0.803
CK1D	0.848	0.291	-3	0.687
RIPK3	0.848	0.006	3	0.679
GCN2	0.847	-0.130	2	0.821
CHAK2	0.846	0.014	-1	0.793
GRK2	0.845	0.184	-2	0.725
PKN2	0.845	0.025	-3	0.800
MLK3	0.844	0.088	2	0.767
NEK6	0.844	-0.034	-2	0.817
PIM1	0.844	0.047	-3	0.755
CK1A2	0.844	0.271	-3	0.687
RSK2	0.843	0.043	-3	0.719
WNK1	0.843	-0.028	-2	0.889
NEK7	0.843	-0.096	-3	0.843
DYRK2	0.843	0.108	1	0.736
NIK	0.843	-0.062	-3	0.849
ICK	0.842	0.065	-3	0.795
CDKL5	0.842	0.045	-3	0.747
PASK	0.841	0.245	-3	0.841
JNK2	0.841	0.146	1	0.653
JNK3	0.841	0.134	1	0.674
CLK2	0.841	0.180	-3	0.710
NDR1	0.841	-0.042	-3	0.793
PDHK1	0.841	-0.204	1	0.801
NUAK2	0.840	-0.015	-3	0.796
PKN3	0.840	-0.040	-3	0.779
FAM20C	0.840	0.053	2	0.589
CDK8	0.839	0.070	1	0.688
GRK3	0.839	0.204	-2	0.690
HIPK2	0.839	0.138	1	0.660
CAMK2A	0.839	0.092	2	0.832
CAMLCK	0.839	-0.049	-2	0.829
CK1G1	0.839	0.203	-3	0.732
DAPK2	0.839	-0.034	-3	0.825
CDK18	0.838	0.119	1	0.637
ULK2	0.838	-0.207	2	0.780
CAMK2B	0.838	0.072	2	0.800
MLK4	0.838	0.075	2	0.741
BCKDK	0.838	-0.112	-1	0.761
HUNK	0.838	-0.105	2	0.833
SRPK3	0.837	0.063	-3	0.708
P38B	0.837	0.142	1	0.659
ACVR2B	0.837	0.132	-2	0.713
GSK3A	0.837	0.204	4	0.585
PKCD	0.837	0.004	2	0.799
ANKRD3	0.837	-0.049	1	0.821
TGFBR1	0.836	0.071	-2	0.730
MEKK3	0.836	0.143	1	0.784
ERK1	0.836	0.116	1	0.654
MASTL	0.836	-0.176	-2	0.811
CDK19	0.836	0.081	1	0.655
MLK2	0.836	-0.061	2	0.825
PKACG	0.835	-0.020	-2	0.744
CDK5	0.835	0.107	1	0.712
PRKD1	0.835	-0.013	-3	0.759
BMPR1A	0.835	0.170	1	0.763
PLK1	0.835	0.030	-2	0.748
P38G	0.835	0.119	1	0.588
YSK4	0.835	0.014	1	0.749
LATS1	0.834	0.057	-3	0.816
ALK4	0.834	0.024	-2	0.755
ATM	0.834	-0.029	1	0.707
CAMK2D	0.834	-0.042	-3	0.780
P90RSK	0.834	-0.020	-3	0.718
ACVR2A	0.834	0.095	-2	0.690
CDK3	0.834	0.134	1	0.609
PKR	0.833	0.020	1	0.812
CK2A2	0.833	0.203	1	0.698
P38A	0.833	0.105	1	0.725
DRAK1	0.833	0.114	1	0.791
TGFBR2	0.833	-0.111	-2	0.709
SRPK2	0.833	0.043	-3	0.637
RSK4	0.833	0.052	-3	0.699
MST3	0.832	0.138	2	0.867
RIPK1	0.832	-0.127	1	0.787
AURC	0.832	0.030	-2	0.646
TLK2	0.832	0.015	1	0.775
LATS2	0.832	-0.034	-5	0.742
HIPK1	0.832	0.097	1	0.750
PRKD2	0.832	-0.012	-3	0.700
PKCG	0.831	0.006	2	0.761
CDK13	0.831	0.057	1	0.670
DYRK4	0.831	0.127	1	0.662
IRE1	0.831	-0.058	1	0.771
PKCB	0.831	0.012	2	0.756
CDK17	0.831	0.094	1	0.593
MARK4	0.831	-0.100	4	0.834
MEK1	0.831	-0.039	2	0.857
NEK9	0.831	-0.166	2	0.838
MAPKAPK2	0.831	0.003	-3	0.673
TTBK2	0.830	-0.101	2	0.702
ALK2	0.830	0.049	-2	0.745
CLK4	0.830	0.047	-3	0.723
GAK	0.829	0.226	1	0.824
PKCA	0.829	0.020	2	0.748
AMPKA1	0.829	-0.100	-3	0.805
P70S6KB	0.829	-0.062	-3	0.745
CDK2	0.829	0.060	1	0.745
CDK7	0.829	0.032	1	0.695
ULK1	0.828	-0.210	-3	0.786
PKACB	0.828	0.031	-2	0.667
CK2A1	0.828	0.216	1	0.685
MSK1	0.828	0.024	-3	0.704
VRK2	0.827	-0.139	1	0.829
GSK3B	0.827	0.141	4	0.580
RSK3	0.827	-0.056	-3	0.715
JNK1	0.827	0.127	1	0.639
ERK2	0.827	0.055	1	0.692
P38D	0.826	0.130	1	0.585
PRKX	0.826	0.062	-3	0.636
PLK3	0.826	-0.011	2	0.789
TAO3	0.826	0.074	1	0.771
MAPKAPK3	0.826	-0.090	-3	0.707
DNAPK	0.826	0.003	1	0.662
PAK1	0.826	-0.063	-2	0.779
SMG1	0.826	-0.058	1	0.725
TSSK2	0.825	-0.085	-5	0.828
WNK3	0.825	-0.299	1	0.776
PRP4	0.825	0.052	-3	0.748
AURA	0.825	0.020	-2	0.613
MYLK4	0.825	-0.012	-2	0.764
MSK2	0.824	-0.055	-3	0.709
GCK	0.824	0.186	1	0.812
CDK12	0.824	0.052	1	0.647
PKCZ	0.824	-0.046	2	0.784
CDK14	0.824	0.086	1	0.684
CDK16	0.823	0.103	1	0.605
MEKK2	0.823	0.014	2	0.809
PKCH	0.823	-0.044	2	0.738
CDK10	0.822	0.105	1	0.672
CK1A	0.822	0.271	-3	0.616
CLK1	0.822	0.035	-3	0.685
MEK5	0.822	-0.109	2	0.833
CAMK4	0.821	-0.140	-3	0.773
TSSK1	0.820	-0.086	-3	0.818
AMPKA2	0.820	-0.109	-3	0.768
MPSK1	0.820	0.095	1	0.791
ZAK	0.820	-0.061	1	0.746
AKT2	0.820	0.001	-3	0.638
PINK1	0.820	-0.091	1	0.828
NIM1	0.819	-0.168	3	0.704
NEK11	0.818	-0.003	1	0.777
AURB	0.818	-0.028	-2	0.643
QSK	0.817	-0.075	4	0.808
CHAK1	0.817	-0.159	2	0.758
MNK1	0.817	-0.061	-2	0.783
IRE2	0.817	-0.109	2	0.739
DYRK1B	0.817	0.045	1	0.690
DYRK1A	0.817	0.029	1	0.742
NEK2	0.817	-0.162	2	0.815
PLK2	0.816	0.100	-3	0.854
MNK2	0.816	-0.088	-2	0.779
PAK3	0.816	-0.143	-2	0.771
CDK9	0.816	0.000	1	0.675
TLK1	0.816	-0.085	-2	0.787
BRAF	0.816	-0.101	-4	0.815
MEKK1	0.816	-0.139	1	0.770
HPK1	0.816	0.121	1	0.800
CAMK1G	0.816	-0.055	-3	0.708
PAK2	0.815	-0.117	-2	0.760
QIK	0.815	-0.172	-3	0.783
NEK5	0.815	-0.099	1	0.791
SGK3	0.815	-0.048	-3	0.711
DYRK3	0.815	0.039	1	0.754
MST2	0.815	0.043	1	0.789
MARK3	0.814	-0.060	4	0.760
PKG2	0.814	-0.044	-2	0.670
TAK1	0.814	0.119	1	0.803
HIPK3	0.814	0.021	1	0.737
PRKD3	0.814	-0.078	-3	0.684
PIM2	0.813	-0.033	-3	0.688
MAK	0.813	0.141	-2	0.786
PHKG1	0.812	-0.133	-3	0.780
NUAK1	0.812	-0.118	-3	0.731
PLK4	0.812	-0.130	2	0.634
BRSK1	0.810	-0.112	-3	0.739
SMMLCK	0.810	-0.066	-3	0.771
MINK	0.810	0.043	1	0.783
SIK	0.810	-0.113	-3	0.710
NEK8	0.810	-0.097	2	0.822
PERK	0.810	-0.194	-2	0.763
WNK4	0.809	-0.168	-2	0.876
TNIK	0.809	0.042	3	0.816
KHS2	0.808	0.116	1	0.800
MELK	0.808	-0.177	-3	0.737
EEF2K	0.808	0.025	3	0.804
DCAMKL1	0.808	-0.103	-3	0.731
PKCE	0.808	0.003	2	0.746
ERK7	0.807	0.038	2	0.574
MARK2	0.807	-0.114	4	0.721
PDK1	0.806	-0.087	1	0.759
PKACA	0.806	-0.017	-2	0.610
CAMKK1	0.805	-0.161	-2	0.742
TAO2	0.805	-0.096	2	0.847
PAK6	0.805	-0.073	-2	0.680
DAPK1	0.805	0.013	-3	0.748
CDK6	0.805	0.062	1	0.657
DAPK3	0.804	-0.028	-3	0.758
BMPR2_TYR	0.804	0.325	-1	0.884
MAP3K15	0.804	-0.067	1	0.728
LKB1	0.804	-0.112	-3	0.804
HGK	0.804	-0.026	3	0.809
HRI	0.804	-0.278	-2	0.775
KHS1	0.804	0.052	1	0.776
CHK1	0.804	-0.158	-3	0.760
PKCT	0.803	-0.093	2	0.740
PDHK4_TYR	0.803	0.319	2	0.897
SLK	0.803	-0.024	-2	0.702
MARK1	0.803	-0.132	4	0.778
BRSK2	0.803	-0.181	-3	0.751
IRAK4	0.803	-0.188	1	0.762
MAPKAPK5	0.803	-0.183	-3	0.663
AKT1	0.802	-0.037	-3	0.650
OSR1	0.802	0.074	2	0.821
MAP2K6_TYR	0.802	0.308	-1	0.854
PKCI	0.802	-0.074	2	0.759
CAMKK2	0.802	-0.159	-2	0.735
MST1	0.802	-0.032	1	0.774
SNRK	0.802	-0.268	2	0.679
PDHK3_TYR	0.801	0.236	4	0.917
LRRK2	0.801	-0.116	2	0.850
YANK3	0.800	0.042	2	0.427
PDHK1_TYR	0.800	0.278	-1	0.872
MEKK6	0.800	-0.126	1	0.757
TTBK1	0.800	-0.166	2	0.620
STK33	0.799	-0.102	2	0.638
NEK4	0.798	-0.168	1	0.768
CK1G3	0.798	0.230	-3	0.576
DCAMKL2	0.798	-0.135	-3	0.743
CDK4	0.797	0.034	1	0.637
MOK	0.797	0.064	1	0.766
VRK1	0.797	-0.135	2	0.825
MAP2K4_TYR	0.795	0.155	-1	0.842
SSTK	0.795	-0.137	4	0.798
P70S6K	0.795	-0.118	-3	0.648
LOK	0.794	-0.102	-2	0.752
SGK1	0.794	-0.020	-3	0.562
ROCK2	0.794	-0.031	-3	0.736
CAMK1D	0.793	-0.096	-3	0.623
AKT3	0.792	-0.016	-3	0.577
PHKG2	0.792	-0.163	-3	0.735
NEK1	0.791	-0.174	1	0.764
BUB1	0.791	0.038	-5	0.805
ALPHAK3	0.791	0.044	-1	0.752
IRAK1	0.791	-0.327	-1	0.688
YSK1	0.790	-0.099	2	0.817
TESK1_TYR	0.790	-0.021	3	0.819
MRCKA	0.790	-0.061	-3	0.698
MRCKB	0.789	-0.056	-3	0.681
CK1G2	0.789	0.238	-3	0.661
MAP2K7_TYR	0.789	-0.061	2	0.863
TTK	0.789	-0.028	-2	0.763
PBK	0.788	-0.039	1	0.740
PAK5	0.788	-0.112	-2	0.624
CHK2	0.787	-0.068	-3	0.573
DMPK1	0.786	-0.013	-3	0.710
PKMYT1_TYR	0.786	-0.073	3	0.786
HASPIN	0.785	-0.023	-1	0.647
PAK4	0.785	-0.094	-2	0.630
TXK	0.785	0.207	1	0.803
PINK1_TYR	0.784	-0.114	1	0.798
PKN1	0.783	-0.106	-3	0.656
MYO3A	0.783	-0.033	1	0.774
MYO3B	0.782	-0.041	2	0.825
FGR	0.781	0.067	1	0.810
EPHA6	0.780	0.046	-1	0.862
MEK2	0.780	-0.312	2	0.808
PTK2	0.780	0.254	-1	0.847
FYN	0.779	0.191	-1	0.840
RIPK2	0.779	-0.302	1	0.704
LIMK2_TYR	0.779	-0.090	-3	0.842
EPHB4	0.779	0.023	-1	0.818
CAMK1A	0.779	-0.094	-3	0.599
ASK1	0.778	-0.154	1	0.711
SYK	0.777	0.259	-1	0.820
YES1	0.777	0.013	-1	0.813
FLT1	0.776	0.094	-1	0.833
ROCK1	0.776	-0.065	-3	0.697
SBK	0.776	-0.058	-3	0.507
LCK	0.776	0.106	-1	0.840
YANK2	0.776	0.044	2	0.442
EPHA4	0.775	0.036	2	0.802
BLK	0.775	0.114	-1	0.841
RET	0.775	-0.156	1	0.757
CSF1R	0.773	-0.072	3	0.707
ABL2	0.772	-0.023	-1	0.761
BIKE	0.772	-0.025	1	0.714
HCK	0.772	0.004	-1	0.822
LIMK1_TYR	0.772	-0.250	2	0.839
CRIK	0.772	-0.059	-3	0.645
MST1R	0.772	-0.174	3	0.723
KIT	0.771	-0.035	3	0.714
INSRR	0.771	-0.040	3	0.656
SRMS	0.770	0.009	1	0.795
ITK	0.770	0.030	-1	0.772
JAK3	0.770	-0.087	1	0.729
MET	0.770	0.013	3	0.692
STLK3	0.770	-0.142	1	0.717
TAO1	0.769	-0.153	1	0.696
KDR	0.769	-0.052	3	0.677
FER	0.769	-0.095	1	0.798
BMX	0.768	0.037	-1	0.706
EPHB1	0.767	-0.029	1	0.782
ABL1	0.767	-0.053	-1	0.747
TYRO3	0.767	-0.197	3	0.704
DDR1	0.766	-0.230	4	0.845
TYK2	0.766	-0.295	1	0.751
EPHB2	0.766	-0.009	-1	0.805
JAK2	0.765	-0.233	1	0.744
WEE1_TYR	0.765	-0.031	-1	0.705
ROS1	0.765	-0.213	3	0.668
NEK3	0.764	-0.299	1	0.714
FGFR2	0.763	-0.147	3	0.715
SRC	0.763	0.052	-1	0.808
EPHB3	0.763	-0.073	-1	0.800
ERBB2	0.762	-0.067	1	0.718
EPHA7	0.761	-0.024	2	0.794
PKG1	0.761	-0.128	-2	0.578
EPHA3	0.760	-0.066	2	0.766
TEC	0.760	-0.061	-1	0.684
LYN	0.760	-0.013	3	0.642
FLT3	0.759	-0.174	3	0.711
FGFR3	0.759	-0.085	3	0.689
TNK2	0.759	-0.151	3	0.658
MERTK	0.758	-0.103	3	0.684
EPHA8	0.757	0.004	-1	0.813
FRK	0.757	-0.055	-1	0.817
MATK	0.757	-0.067	-1	0.690
PDGFRB	0.756	-0.253	3	0.714
EPHA5	0.756	-0.015	2	0.783
EGFR	0.756	-0.028	1	0.626
ZAP70	0.756	0.140	-1	0.739
NEK10_TYR	0.756	-0.188	1	0.653
ERBB4	0.755	0.060	1	0.661
AAK1	0.755	0.015	1	0.622
JAK1	0.754	-0.162	1	0.701
BTK	0.754	-0.185	-1	0.712
FGFR4	0.754	-0.039	-1	0.742
TNNI3K_TYR	0.753	-0.154	1	0.761
NTRK1	0.753	-0.199	-1	0.779
PTK2B	0.753	-0.028	-1	0.719
FLT4	0.752	-0.169	3	0.680
PTK6	0.751	-0.221	-1	0.669
TEK	0.751	-0.235	3	0.641
FGFR1	0.750	-0.260	3	0.663
EPHA2	0.750	0.014	-1	0.786
DDR2	0.750	-0.107	3	0.640
TNK1	0.749	-0.245	3	0.694
CSK	0.749	-0.108	2	0.790
INSR	0.748	-0.179	3	0.633
NTRK3	0.748	-0.145	-1	0.734
AXL	0.748	-0.248	3	0.674
LTK	0.747	-0.222	3	0.648
ALK	0.747	-0.232	3	0.615
PDGFRA	0.747	-0.325	3	0.713
EPHA1	0.746	-0.186	3	0.668
NTRK2	0.744	-0.262	3	0.665
IGF1R	0.740	-0.123	3	0.578
MUSK	0.729	-0.202	1	0.622
FES	0.728	-0.104	-1	0.672