Motif 461 (n=144)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L170 | C1orf226 | S237 | ochoa | Uncharacterized protein C1orf226 | None |
| A6NKT7 | RGPD3 | S1605 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8CG34 | POM121C | S274 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00418 | EEF2K | S474 | ochoa|psp | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O14545 | TRAFD1 | S501 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14641 | DVL2 | S155 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14713 | ITGB1BP1 | S25 | ochoa|psp | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}. |
| O14715 | RGPD8 | S1604 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15231 | ZNF185 | S78 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O15231 | ZNF185 | S465 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O60291 | MGRN1 | S471 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O75044 | SRGAP2 | S896 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75179 | ANKRD17 | S2056 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75376 | NCOR1 | S2098 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94880 | PHF14 | S308 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94885 | SASH1 | S718 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94972 | TRIM37 | S817 | ochoa | E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) | E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}. |
| O95197 | RTN3 | S243 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95817 | BAG3 | S194 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P00533 | EGFR | S1039 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P02545 | LMNA | S615 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P08670 | VIM | S39 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P0DJD0 | RGPD1 | S1589 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1597 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P15924 | DSP | S2597 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P15924 | DSP | T2853 | ochoa|psp | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16144 | ITGB4 | S1498 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17661 | DES | S42 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P20700 | LMNB1 | S405 | ochoa|psp | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P23497 | SP100 | S205 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P38398 | BRCA1 | S1610 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42166 | TMPO | S180 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42858 | HTT | S429 | ochoa|psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46821 | MAP1B | S1168 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | Y1336 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46939 | UTRN | S2223 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P48730 | CSNK1D | S396 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49321 | NASP | S704 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49585 | PCYT1A | S343 | ochoa | Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}. |
| P49792 | RANBP2 | S2580 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51116 | FXR2 | S634 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P53355 | DAPK1 | S333 | ochoa | Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing. |
| P55196 | AFDN | S1314 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| Q01167 | FOXK2 | S381 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q03164 | KMT2A | S938 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q04656 | ATP7A | S1444 | ochoa | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q04726 | TLE3 | S217 | ochoa|psp | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q08AD1 | CAMSAP2 | S1339 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S5749 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S315 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S532 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1656 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12929 | EPS8 | S495 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q12968 | NFATC3 | S177 | psp | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13131 | PRKAA1 | S520 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13177 | PAK2 | S32 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13546 | RIPK1 | S345 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13905 | RAPGEF1 | S349 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14966 | ZNF638 | S628 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15058 | KIF14 | S1231 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15311 | RALBP1 | T25 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15555 | MAPRE2 | T242 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q15648 | MED1 | S784 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15648 | MED1 | S1479 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q16825 | PTPN21 | S602 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q2M2I8 | AAK1 | S690 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q32P44 | EML3 | S198 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q53ET0 | CRTC2 | S504 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q53GG5 | PDLIM3 | S264 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5M775 | SPECC1 | S134 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5TCY1 | TTBK1 | S529 | ochoa | Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) | Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. {ECO:0000269|PubMed:16923168}. |
| Q5VT52 | RPRD2 | S593 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | S942 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VU43 | PDE4DIP | S740 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VZ89 | DENND4C | S1337 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5W0Z9 | ZDHHC20 | S330 | ochoa | Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245). May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. {ECO:0000250|UniProtKB:Q5Y5T1, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:29326245, ECO:0000269|PubMed:33219126}.; FUNCTION: (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q6IAA8 | LAMTOR1 | S110 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6P1L5 | FAM117B | S426 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P6C2 | ALKBH5 | S375 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6PIJ6 | FBXO38 | S736 | ochoa | F-box only protein 38 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
| Q6PJE2 | POMZP3 | S32 | ochoa | POM121 and ZP3 fusion protein (POM-ZP3) | None |
| Q6R327 | RICTOR | S1231 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6XZF7 | DNMBP | S1365 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6Y7W6 | GIGYF2 | S388 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q71F23 | CENPU | S108 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7KZI7 | MARK2 | S483 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z3J3 | RGPD4 | S1605 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6Z7 | HUWE1 | S2546 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86YV5 | PRAG1 | S759 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q86YV5 | PRAG1 | Y864 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IVF2 | AHNAK2 | S294 | ochoa | Protein AHNAK2 | None |
| Q8IY57 | YAF2 | S163 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8N1G2 | CMTR1 | S40 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N6H7 | ARFGAP2 | S334 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NCN4 | RNF169 | S520 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8TEV9 | SMCR8 | S414 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WU79 | SMAP2 | S237 | ochoa | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}. |
| Q8WWI1 | LMO7 | S1009 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92614 | MYO18A | S154 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q96HA1 | POM121 | S297 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96N67 | DOCK7 | S910 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96SU4 | OSBPL9 | S338 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q99666 | RGPD5 | S1604 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BSQ5 | CCM2 | S178 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BT25 | HAUS8 | S143 | psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9C0D5 | TANC1 | S1677 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H1A4 | ANAPC1 | S355 | ochoa|psp | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H4L5 | OSBPL3 | S30 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H4L5 | OSBPL3 | S323 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H4L5 | OSBPL3 | S386 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H4X1 | RGCC | S101 | ochoa | Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32) | Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}. |
| Q9H6K5 | PRR36 | S1123 | ochoa | Proline-rich protein 36 | None |
| Q9H773 | DCTPP1 | S150 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
| Q9H8V3 | ECT2 | S880 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NQX3 | GPHN | S280 | ochoa | Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}. |
| Q9NR48 | ASH1L | S1701 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRA8 | EIF4ENIF1 | S693 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NZ52 | GGA3 | S384 | ochoa | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
| Q9NZB2 | FAM120A | Y431 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZB2 | FAM120A | S456 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P1Y6 | PHRF1 | S864 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P219 | CCDC88C | S1580 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P275 | USP36 | S632 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2D0 | IBTK | S1018 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2P5 | HECW2 | S404 | ochoa | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269|PubMed:12890487, ECO:0000269|PubMed:24163370}. |
| Q9UBW5 | BIN2 | S395 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UKI8 | TLK1 | S94 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9ULV3 | CIZ1 | S587 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UQ35 | SRRM2 | S831 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S887 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1024 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1093 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1455 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T1531 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2U8 | LEMD3 | S421 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2W1 | THRAP3 | S320 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2X7 | GIT1 | S585 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y4B5 | MTCL1 | S790 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F9 | RIPOR2 | S33 | ochoa | Rho family-interacting cell polarization regulator 2 | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}. |
| Q9Y5S2 | CDC42BPB | S1671 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| P47756 | CAPZB | S204 | Sugiyama | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| O15111 | CHUK | S414 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O14974 | PPP1R12A | S692 | Sugiyama | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| Q96L34 | MARK4 | S557 | Sugiyama | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.116458e-07 | 6.674 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.864921e-06 | 5.543 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 6.200119e-06 | 5.208 |
| R-HSA-68875 | Mitotic Prophase | 4.046232e-05 | 4.393 |
| R-HSA-75153 | Apoptotic execution phase | 1.624655e-04 | 3.789 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.877174e-04 | 3.726 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.424071e-04 | 3.465 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.757736e-04 | 3.425 |
| R-HSA-68882 | Mitotic Anaphase | 3.864050e-04 | 3.413 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.982921e-04 | 3.400 |
| R-HSA-68886 | M Phase | 4.036347e-04 | 3.394 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.657019e-04 | 3.332 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 1.031224e-03 | 2.987 |
| R-HSA-109581 | Apoptosis | 1.539796e-03 | 2.813 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.328661e-03 | 2.478 |
| R-HSA-1640170 | Cell Cycle | 3.276954e-03 | 2.485 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 7.656746e-03 | 2.116 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.734532e-03 | 2.325 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 5.105833e-03 | 2.292 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 5.105833e-03 | 2.292 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.899875e-03 | 2.229 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.899875e-03 | 2.229 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 6.323022e-03 | 2.199 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 7.222507e-03 | 2.141 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 9.238889e-03 | 2.034 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 6.641897e-03 | 2.178 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 9.238889e-03 | 2.034 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 5.693603e-03 | 2.245 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 8.194050e-03 | 2.087 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 6.323022e-03 | 2.199 |
| R-HSA-180746 | Nuclear import of Rev protein | 6.763840e-03 | 2.170 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.791941e-03 | 2.168 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.424942e-03 | 2.266 |
| R-HSA-5357801 | Programmed Cell Death | 5.221109e-03 | 2.282 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.813170e-03 | 2.318 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 8.707236e-03 | 2.060 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 9.238889e-03 | 2.034 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 9.238889e-03 | 2.034 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.947356e-03 | 2.306 |
| R-HSA-9020591 | Interleukin-12 signaling | 8.026300e-03 | 2.095 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 9.789141e-03 | 2.009 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 9.789141e-03 | 2.009 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 9.789141e-03 | 2.009 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.035812e-02 | 1.985 |
| R-HSA-165159 | MTOR signalling | 1.155269e-02 | 1.937 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.368478e-02 | 1.864 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.368478e-02 | 1.864 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.348760e-02 | 1.870 |
| R-HSA-9909396 | Circadian clock | 1.263112e-02 | 1.899 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.258535e-02 | 1.900 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.417106e-02 | 1.849 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 1.833681e-02 | 1.737 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.833681e-02 | 1.737 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.833681e-02 | 1.737 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.651809e-02 | 1.782 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.798328e-02 | 1.745 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.651809e-02 | 1.782 |
| R-HSA-1221632 | Meiotic synapsis | 1.950049e-02 | 1.710 |
| R-HSA-3928664 | Ephrin signaling | 1.957831e-02 | 1.708 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.957831e-02 | 1.708 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.119064e-02 | 1.674 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.145128e-02 | 1.669 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.296664e-02 | 1.639 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.483407e-02 | 1.605 |
| R-HSA-191859 | snRNP Assembly | 2.483407e-02 | 1.605 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.676933e-02 | 1.572 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.737958e-02 | 1.563 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 2.737958e-02 | 1.563 |
| R-HSA-9707616 | Heme signaling | 2.776641e-02 | 1.556 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.816214e-02 | 1.550 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.816214e-02 | 1.550 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.776641e-02 | 1.556 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.003015e-02 | 1.522 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.194611e-02 | 1.496 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.194611e-02 | 1.496 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.415916e-02 | 1.466 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.506875e-02 | 1.455 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.591774e-02 | 1.445 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 3.633961e-02 | 1.440 |
| R-HSA-3371556 | Cellular response to heat stress | 3.750305e-02 | 1.426 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.797141e-02 | 1.421 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.797141e-02 | 1.421 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.880826e-02 | 1.411 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.439205e-02 | 1.353 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.001840e-02 | 1.398 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.439205e-02 | 1.353 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.635248e-02 | 1.334 |
| R-HSA-9659379 | Sensory processing of sound | 4.767538e-02 | 1.322 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.010791e-02 | 1.397 |
| R-HSA-162582 | Signal Transduction | 4.495275e-02 | 1.347 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.249560e-02 | 1.372 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.219263e-02 | 1.375 |
| R-HSA-9843745 | Adipogenesis | 4.852721e-02 | 1.314 |
| R-HSA-6806834 | Signaling by MET | 4.901676e-02 | 1.310 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.037652e-02 | 1.298 |
| R-HSA-9609690 | HCMV Early Events | 5.049395e-02 | 1.297 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.118216e-02 | 1.291 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.401442e-02 | 1.267 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 5.401442e-02 | 1.267 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 6.273069e-02 | 1.203 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 7.136719e-02 | 1.147 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 7.136719e-02 | 1.147 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 7.136719e-02 | 1.147 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 7.992463e-02 | 1.097 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 8.840374e-02 | 1.054 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.680523e-02 | 1.014 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 9.680523e-02 | 1.014 |
| R-HSA-8875656 | MET receptor recycling | 9.680523e-02 | 1.014 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.051298e-01 | 0.978 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.051298e-01 | 0.978 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.296490e-01 | 0.887 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.535008e-01 | 0.814 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.613062e-01 | 0.792 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.613062e-01 | 0.792 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.613062e-01 | 0.792 |
| R-HSA-390522 | Striated Muscle Contraction | 5.352332e-02 | 1.271 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.690401e-01 | 0.772 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.690401e-01 | 0.772 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.992737e-01 | 0.701 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.992737e-01 | 0.701 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.066598e-01 | 0.685 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.066598e-01 | 0.685 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.066598e-01 | 0.685 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.066598e-01 | 0.685 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.139782e-01 | 0.670 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.139782e-01 | 0.670 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.495764e-01 | 0.603 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.407308e-01 | 0.852 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.407308e-01 | 0.852 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.502584e-01 | 0.823 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.729520e-01 | 0.762 |
| R-HSA-380287 | Centrosome maturation | 1.795368e-01 | 0.746 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.894841e-01 | 0.722 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.163385e-01 | 0.665 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.163385e-01 | 0.665 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.265010e-01 | 0.645 |
| R-HSA-1989781 | PPARA activates gene expression | 2.162754e-01 | 0.665 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.565015e-01 | 0.591 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.139782e-01 | 0.670 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.139782e-01 | 0.670 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.210868e-01 | 0.655 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.842960e-01 | 0.734 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.842960e-01 | 0.734 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.175456e-02 | 1.286 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.565015e-01 | 0.591 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.496162e-02 | 1.187 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.918193e-01 | 0.717 |
| R-HSA-180292 | GAB1 signalosome | 1.918193e-01 | 0.717 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.690401e-01 | 0.772 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.425872e-01 | 0.615 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.376728e-01 | 0.861 |
| R-HSA-4641265 | Repression of WNT target genes | 1.376728e-01 | 0.861 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.471115e-02 | 1.072 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.995048e-01 | 0.700 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.051298e-01 | 0.978 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.376728e-01 | 0.861 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.690401e-01 | 0.772 |
| R-HSA-9664420 | Killing mechanisms | 1.690401e-01 | 0.772 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.842960e-01 | 0.734 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 8.984494e-02 | 1.047 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.380908e-01 | 0.623 |
| R-HSA-75893 | TNF signaling | 1.190687e-01 | 0.924 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.565015e-01 | 0.591 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 5.401442e-02 | 1.267 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.138782e-01 | 0.670 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.879321e-01 | 0.726 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.690401e-01 | 0.772 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.690401e-01 | 0.772 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 7.136719e-02 | 1.147 |
| R-HSA-3371378 | Regulation by c-FLIP | 9.680523e-02 | 1.014 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.133782e-01 | 0.945 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.133782e-01 | 0.945 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.133782e-01 | 0.945 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.376728e-01 | 0.861 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.456232e-01 | 0.837 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.613062e-01 | 0.792 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.767031e-01 | 0.753 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.767031e-01 | 0.753 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.284144e-01 | 0.641 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.425872e-01 | 0.615 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.918193e-01 | 0.717 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 8.840374e-02 | 1.054 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.842960e-01 | 0.734 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.918193e-01 | 0.717 |
| R-HSA-3295583 | TRP channels | 2.565015e-01 | 0.591 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.456507e-02 | 1.263 |
| R-HSA-1500620 | Meiosis | 5.599732e-02 | 1.252 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.282469e-01 | 0.892 |
| R-HSA-69416 | Dimerization of procaspase-8 | 9.680523e-02 | 1.014 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.051298e-01 | 0.978 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.296490e-01 | 0.887 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.535008e-01 | 0.814 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.767031e-01 | 0.753 |
| R-HSA-8875878 | MET promotes cell motility | 6.577286e-02 | 1.182 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 7.352710e-02 | 1.134 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.992737e-01 | 0.701 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.631541e-01 | 0.787 |
| R-HSA-68877 | Mitotic Prometaphase | 1.347948e-01 | 0.870 |
| R-HSA-73887 | Death Receptor Signaling | 2.138782e-01 | 0.670 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 9.550193e-02 | 1.020 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.051298e-01 | 0.978 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.565015e-01 | 0.591 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.534628e-01 | 0.814 |
| R-HSA-9609646 | HCMV Infection | 1.068922e-01 | 0.971 |
| R-HSA-428540 | Activation of RAC1 | 1.296490e-01 | 0.887 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.376728e-01 | 0.861 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.376728e-01 | 0.861 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.535008e-01 | 0.814 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.762395e-01 | 0.754 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 7.352710e-02 | 1.134 |
| R-HSA-9612973 | Autophagy | 2.186783e-01 | 0.660 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.221785e-02 | 1.206 |
| R-HSA-164944 | Nef and signal transduction | 7.992463e-02 | 1.097 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.376728e-01 | 0.861 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.376728e-01 | 0.861 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.376728e-01 | 0.861 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 9.180188e-02 | 1.037 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.190369e-02 | 1.208 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 7.136719e-02 | 1.147 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.456232e-01 | 0.837 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.767031e-01 | 0.753 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.842960e-01 | 0.734 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 2.212295e-01 | 0.655 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.565015e-01 | 0.591 |
| R-HSA-170968 | Frs2-mediated activation | 1.456232e-01 | 0.837 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.795368e-01 | 0.746 |
| R-HSA-1632852 | Macroautophagy | 1.810063e-01 | 0.742 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.992737e-01 | 0.701 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.244759e-01 | 0.905 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.162754e-01 | 0.665 |
| R-HSA-1474165 | Reproduction | 1.540697e-01 | 0.812 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.234589e-01 | 0.908 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.762395e-01 | 0.754 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.284144e-01 | 0.641 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.537437e-01 | 0.596 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.231092e-01 | 0.651 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.972718e-01 | 0.705 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.169506e-01 | 0.932 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.086122e-01 | 0.964 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 8.840374e-02 | 1.054 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.051298e-01 | 0.978 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.918193e-01 | 0.717 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.190687e-01 | 0.924 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.435102e-01 | 0.613 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.347273e-01 | 0.629 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.438919e-01 | 0.842 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.715343e-02 | 1.013 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.376728e-01 | 0.861 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 9.836800e-02 | 1.007 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.228004e-02 | 1.206 |
| R-HSA-169893 | Prolonged ERK activation events | 1.690401e-01 | 0.772 |
| R-HSA-389356 | Co-stimulation by CD28 | 9.550193e-02 | 1.020 |
| R-HSA-9610379 | HCMV Late Events | 2.210868e-01 | 0.655 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.680523e-02 | 1.014 |
| R-HSA-9842663 | Signaling by LTK | 1.376728e-01 | 0.861 |
| R-HSA-445144 | Signal transduction by L1 | 2.066598e-01 | 0.685 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.425872e-01 | 0.615 |
| R-HSA-70171 | Glycolysis | 8.471115e-02 | 1.072 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.212295e-01 | 0.655 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.355334e-01 | 0.628 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.098693e-01 | 0.678 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.376728e-01 | 0.861 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.197216e-01 | 0.658 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.984618e-01 | 0.702 |
| R-HSA-3000170 | Syndecan interactions | 2.355334e-01 | 0.628 |
| R-HSA-3000157 | Laminin interactions | 2.495764e-01 | 0.603 |
| R-HSA-4839726 | Chromatin organization | 2.391557e-01 | 0.621 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.531432e-01 | 0.597 |
| R-HSA-1280218 | Adaptive Immune System | 1.188830e-01 | 0.925 |
| R-HSA-73942 | DNA Damage Reversal | 1.613062e-01 | 0.792 |
| R-HSA-2262752 | Cellular responses to stress | 5.850178e-02 | 1.233 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.631541e-01 | 0.787 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.224485e-01 | 0.912 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.828437e-01 | 0.738 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.355334e-01 | 0.628 |
| R-HSA-70326 | Glucose metabolism | 1.224485e-01 | 0.912 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.221093e-01 | 0.913 |
| R-HSA-168256 | Immune System | 2.118188e-01 | 0.674 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 8.429289e-02 | 1.074 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.062204e-01 | 0.686 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.317543e-02 | 1.080 |
| R-HSA-913531 | Interferon Signaling | 1.730624e-01 | 0.762 |
| R-HSA-162906 | HIV Infection | 1.965796e-01 | 0.706 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.145908e-01 | 0.668 |
| R-HSA-449147 | Signaling by Interleukins | 2.499943e-01 | 0.602 |
| R-HSA-2028269 | Signaling by Hippo | 1.842960e-01 | 0.734 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.283444e-01 | 0.641 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.718852e-01 | 0.765 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.660977e-02 | 1.116 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.366979e-01 | 0.626 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.856157e-01 | 0.731 |
| R-HSA-211000 | Gene Silencing by RNA | 9.913085e-02 | 1.004 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.197216e-01 | 0.658 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.401028e-01 | 0.620 |
| R-HSA-72306 | tRNA processing | 2.553130e-01 | 0.593 |
| R-HSA-162587 | HIV Life Cycle | 2.210868e-01 | 0.655 |
| R-HSA-5619102 | SLC transporter disorders | 2.454479e-01 | 0.610 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.572037e-01 | 0.590 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.577883e-01 | 0.589 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.605723e-01 | 0.584 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.605723e-01 | 0.584 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.633631e-01 | 0.579 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.633631e-01 | 0.579 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.701618e-01 | 0.568 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 2.708185e-01 | 0.567 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.768981e-01 | 0.558 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.768981e-01 | 0.558 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.768981e-01 | 0.558 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.768981e-01 | 0.558 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.774994e-01 | 0.557 |
| R-HSA-168255 | Influenza Infection | 2.777004e-01 | 0.556 |
| R-HSA-199991 | Membrane Trafficking | 2.801152e-01 | 0.553 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.810616e-01 | 0.551 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.835727e-01 | 0.547 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.835727e-01 | 0.547 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.835727e-01 | 0.547 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.835727e-01 | 0.547 |
| R-HSA-112311 | Neurotransmitter clearance | 2.835727e-01 | 0.547 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.877159e-01 | 0.541 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.878849e-01 | 0.541 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.901861e-01 | 0.537 |
| R-HSA-182971 | EGFR downregulation | 2.901861e-01 | 0.537 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.901861e-01 | 0.537 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.901861e-01 | 0.537 |
| R-HSA-186763 | Downstream signal transduction | 2.901861e-01 | 0.537 |
| R-HSA-9833110 | RSV-host interactions | 2.912942e-01 | 0.536 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.947015e-01 | 0.531 |
| R-HSA-69275 | G2/M Transition | 2.952469e-01 | 0.530 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.967389e-01 | 0.528 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.967389e-01 | 0.528 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.001524e-01 | 0.523 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.002749e-01 | 0.522 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.015092e-01 | 0.521 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.015092e-01 | 0.521 |
| R-HSA-983712 | Ion channel transport | 3.027908e-01 | 0.519 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.032315e-01 | 0.518 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.032315e-01 | 0.518 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.032315e-01 | 0.518 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.032315e-01 | 0.518 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.032315e-01 | 0.518 |
| R-HSA-5617833 | Cilium Assembly | 3.053078e-01 | 0.515 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.083061e-01 | 0.511 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.096647e-01 | 0.509 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.096647e-01 | 0.509 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.116999e-01 | 0.506 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.116999e-01 | 0.506 |
| R-HSA-202403 | TCR signaling | 3.116999e-01 | 0.506 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 3.116999e-01 | 0.506 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.160388e-01 | 0.500 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.160388e-01 | 0.500 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.160388e-01 | 0.500 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.160388e-01 | 0.500 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.160388e-01 | 0.500 |
| R-HSA-169911 | Regulation of Apoptosis | 3.223545e-01 | 0.492 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.223545e-01 | 0.492 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.223545e-01 | 0.492 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.223545e-01 | 0.492 |
| R-HSA-187687 | Signalling to ERKs | 3.223545e-01 | 0.492 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.252390e-01 | 0.488 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.252390e-01 | 0.488 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.286122e-01 | 0.483 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.286122e-01 | 0.483 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 3.319838e-01 | 0.479 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.334624e-01 | 0.477 |
| R-HSA-4641258 | Degradation of DVL | 3.348125e-01 | 0.475 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.348125e-01 | 0.475 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.348125e-01 | 0.475 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.353493e-01 | 0.475 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.355543e-01 | 0.474 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.380750e-01 | 0.471 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.380750e-01 | 0.471 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.409560e-01 | 0.467 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.409560e-01 | 0.467 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.420654e-01 | 0.466 |
| R-HSA-5693538 | Homology Directed Repair | 3.454157e-01 | 0.462 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.470430e-01 | 0.460 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.470430e-01 | 0.460 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.530743e-01 | 0.452 |
| R-HSA-5260271 | Diseases of Immune System | 3.530743e-01 | 0.452 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.530743e-01 | 0.452 |
| R-HSA-9646399 | Aggrephagy | 3.530743e-01 | 0.452 |
| R-HSA-202433 | Generation of second messenger molecules | 3.530743e-01 | 0.452 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.554330e-01 | 0.449 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.590502e-01 | 0.445 |
| R-HSA-9694548 | Maturation of spike protein | 3.590502e-01 | 0.445 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.590502e-01 | 0.445 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.590502e-01 | 0.445 |
| R-HSA-397014 | Muscle contraction | 3.632404e-01 | 0.440 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.649712e-01 | 0.438 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.649712e-01 | 0.438 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.708380e-01 | 0.431 |
| R-HSA-73928 | Depyrimidination | 3.708380e-01 | 0.431 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.708380e-01 | 0.431 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.720067e-01 | 0.429 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.720067e-01 | 0.429 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.720067e-01 | 0.429 |
| R-HSA-194138 | Signaling by VEGF | 3.720067e-01 | 0.429 |
| R-HSA-8854214 | TBC/RABGAPs | 3.766509e-01 | 0.424 |
| R-HSA-69481 | G2/M Checkpoints | 3.785895e-01 | 0.422 |
| R-HSA-74160 | Gene expression (Transcription) | 3.823523e-01 | 0.418 |
| R-HSA-212436 | Generic Transcription Pathway | 3.839335e-01 | 0.416 |
| R-HSA-774815 | Nucleosome assembly | 3.881171e-01 | 0.411 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.881171e-01 | 0.411 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.881171e-01 | 0.411 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.881171e-01 | 0.411 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.937714e-01 | 0.405 |
| R-HSA-9675135 | Diseases of DNA repair | 3.937714e-01 | 0.405 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.981627e-01 | 0.400 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.993738e-01 | 0.399 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.993738e-01 | 0.399 |
| R-HSA-1483191 | Synthesis of PC | 3.993738e-01 | 0.399 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.142562e-01 | 0.383 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.201614e-01 | 0.377 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.212737e-01 | 0.375 |
| R-HSA-912446 | Meiotic recombination | 4.212737e-01 | 0.375 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.238105e-01 | 0.373 |
| R-HSA-8939211 | ESR-mediated signaling | 4.253295e-01 | 0.371 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.266236e-01 | 0.370 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.266236e-01 | 0.370 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.314546e-01 | 0.365 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.319244e-01 | 0.365 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.319244e-01 | 0.365 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.319244e-01 | 0.365 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.319244e-01 | 0.365 |
| R-HSA-157118 | Signaling by NOTCH | 4.326565e-01 | 0.364 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.371765e-01 | 0.359 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.371765e-01 | 0.359 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.423803e-01 | 0.354 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.423803e-01 | 0.354 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.423803e-01 | 0.354 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.423803e-01 | 0.354 |
| R-HSA-9679506 | SARS-CoV Infections | 4.427207e-01 | 0.354 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.475364e-01 | 0.349 |
| R-HSA-177929 | Signaling by EGFR | 4.475364e-01 | 0.349 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.475364e-01 | 0.349 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.475364e-01 | 0.349 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.475364e-01 | 0.349 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.496199e-01 | 0.347 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.550641e-01 | 0.342 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.577069e-01 | 0.339 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.577069e-01 | 0.339 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.611994e-01 | 0.336 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.627221e-01 | 0.335 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.676913e-01 | 0.330 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.676913e-01 | 0.330 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.676913e-01 | 0.330 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.676913e-01 | 0.330 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.676913e-01 | 0.330 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.676913e-01 | 0.330 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.676913e-01 | 0.330 |
| R-HSA-73894 | DNA Repair | 4.681656e-01 | 0.330 |
| R-HSA-5688426 | Deubiquitination | 4.687557e-01 | 0.329 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.703272e-01 | 0.328 |
| R-HSA-450294 | MAP kinase activation | 4.726149e-01 | 0.325 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.742063e-01 | 0.324 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.774932e-01 | 0.321 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.774932e-01 | 0.321 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.774932e-01 | 0.321 |
| R-HSA-186797 | Signaling by PDGF | 4.774932e-01 | 0.321 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.823267e-01 | 0.317 |
| R-HSA-8848021 | Signaling by PTK6 | 4.823267e-01 | 0.317 |
| R-HSA-373755 | Semaphorin interactions | 4.823267e-01 | 0.317 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.823267e-01 | 0.317 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.853348e-01 | 0.314 |
| R-HSA-9675108 | Nervous system development | 4.865382e-01 | 0.313 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.871158e-01 | 0.312 |
| R-HSA-877300 | Interferon gamma signaling | 4.883049e-01 | 0.311 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.918608e-01 | 0.308 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.965623e-01 | 0.304 |
| R-HSA-9824446 | Viral Infection Pathways | 4.971636e-01 | 0.304 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.012205e-01 | 0.300 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.027700e-01 | 0.299 |
| R-HSA-5218859 | Regulated Necrosis | 5.058359e-01 | 0.296 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.058359e-01 | 0.296 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.058359e-01 | 0.296 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.149399e-01 | 0.288 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.149399e-01 | 0.288 |
| R-HSA-448424 | Interleukin-17 signaling | 5.149399e-01 | 0.288 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.194292e-01 | 0.284 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.194292e-01 | 0.284 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 5.238773e-01 | 0.281 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.282844e-01 | 0.277 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.282844e-01 | 0.277 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.287482e-01 | 0.277 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.326510e-01 | 0.274 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.371314e-01 | 0.270 |
| R-HSA-5689603 | UCH proteinases | 5.412642e-01 | 0.267 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.455114e-01 | 0.263 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.455114e-01 | 0.263 |
| R-HSA-4086400 | PCP/CE pathway | 5.497196e-01 | 0.260 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.497196e-01 | 0.260 |
| R-HSA-2559583 | Cellular Senescence | 5.508760e-01 | 0.259 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.538891e-01 | 0.257 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.580203e-01 | 0.253 |
| R-HSA-9833482 | PKR-mediated signaling | 5.580203e-01 | 0.253 |
| R-HSA-1266738 | Developmental Biology | 5.582464e-01 | 0.253 |
| R-HSA-977225 | Amyloid fiber formation | 5.621134e-01 | 0.250 |
| R-HSA-195721 | Signaling by WNT | 5.659365e-01 | 0.247 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.661689e-01 | 0.247 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.701871e-01 | 0.244 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.741683e-01 | 0.241 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.781128e-01 | 0.238 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.781128e-01 | 0.238 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.781128e-01 | 0.238 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.801017e-01 | 0.236 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.820211e-01 | 0.235 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.820211e-01 | 0.235 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.826890e-01 | 0.235 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.858934e-01 | 0.232 |
| R-HSA-9663891 | Selective autophagy | 5.935315e-01 | 0.227 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.972979e-01 | 0.224 |
| R-HSA-202424 | Downstream TCR signaling | 6.010296e-01 | 0.221 |
| R-HSA-73884 | Base Excision Repair | 6.010296e-01 | 0.221 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.029677e-01 | 0.220 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.029677e-01 | 0.220 |
| R-HSA-422475 | Axon guidance | 6.037853e-01 | 0.219 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.120198e-01 | 0.213 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.156160e-01 | 0.211 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.172565e-01 | 0.210 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.172565e-01 | 0.210 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.191791e-01 | 0.208 |
| R-HSA-1474290 | Collagen formation | 6.191791e-01 | 0.208 |
| R-HSA-8957322 | Metabolism of steroids | 6.192229e-01 | 0.208 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.296727e-01 | 0.201 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.331063e-01 | 0.199 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.343299e-01 | 0.198 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.365083e-01 | 0.196 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.365083e-01 | 0.196 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.365083e-01 | 0.196 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.366611e-01 | 0.196 |
| R-HSA-3214847 | HATs acetylate histones | 6.398790e-01 | 0.194 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.398790e-01 | 0.194 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.465274e-01 | 0.189 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.465274e-01 | 0.189 |
| R-HSA-6798695 | Neutrophil degranulation | 6.482425e-01 | 0.188 |
| R-HSA-8951664 | Neddylation | 6.548957e-01 | 0.184 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.594608e-01 | 0.181 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.594608e-01 | 0.181 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.657501e-01 | 0.177 |
| R-HSA-112316 | Neuronal System | 6.657879e-01 | 0.177 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.659204e-01 | 0.177 |
| R-HSA-69239 | Synthesis of DNA | 6.688513e-01 | 0.175 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.719240e-01 | 0.173 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.719240e-01 | 0.173 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.719240e-01 | 0.173 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.749683e-01 | 0.171 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.749683e-01 | 0.171 |
| R-HSA-6803157 | Antimicrobial peptides | 6.809731e-01 | 0.167 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.839340e-01 | 0.165 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.868676e-01 | 0.163 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.955072e-01 | 0.158 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.983341e-01 | 0.156 |
| R-HSA-373760 | L1CAM interactions | 7.011350e-01 | 0.154 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.093834e-01 | 0.149 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.093834e-01 | 0.149 |
| R-HSA-73886 | Chromosome Maintenance | 7.147564e-01 | 0.146 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.174057e-01 | 0.144 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.174057e-01 | 0.144 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.200307e-01 | 0.143 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.200307e-01 | 0.143 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.226314e-01 | 0.141 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.352792e-01 | 0.134 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.401765e-01 | 0.131 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.588816e-01 | 0.120 |
| R-HSA-446728 | Cell junction organization | 7.644295e-01 | 0.117 |
| R-HSA-6807070 | PTEN Regulation | 7.655458e-01 | 0.116 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.783302e-01 | 0.109 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.801222e-01 | 0.108 |
| R-HSA-69242 | S Phase | 7.864659e-01 | 0.104 |
| R-HSA-166520 | Signaling by NTRKs | 7.864659e-01 | 0.104 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.904219e-01 | 0.102 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.923725e-01 | 0.101 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.943050e-01 | 0.100 |
| R-HSA-69306 | DNA Replication | 7.962197e-01 | 0.099 |
| R-HSA-9711097 | Cellular response to starvation | 8.055308e-01 | 0.094 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.091358e-01 | 0.092 |
| R-HSA-1500931 | Cell-Cell communication | 8.196234e-01 | 0.086 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.196363e-01 | 0.086 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.278086e-01 | 0.082 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.325783e-01 | 0.080 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.356850e-01 | 0.078 |
| R-HSA-1474244 | Extracellular matrix organization | 8.380405e-01 | 0.077 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.545284e-01 | 0.068 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.558080e-01 | 0.068 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.624855e-01 | 0.064 |
| R-HSA-597592 | Post-translational protein modification | 8.628217e-01 | 0.064 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.736175e-01 | 0.059 |
| R-HSA-72172 | mRNA Splicing | 8.759671e-01 | 0.058 |
| R-HSA-6805567 | Keratinization | 8.782732e-01 | 0.056 |
| R-HSA-5663205 | Infectious disease | 8.788152e-01 | 0.056 |
| R-HSA-168249 | Innate Immune System | 8.852755e-01 | 0.053 |
| R-HSA-418990 | Adherens junctions interactions | 8.912425e-01 | 0.050 |
| R-HSA-1643685 | Disease | 9.004536e-01 | 0.046 |
| R-HSA-8953854 | Metabolism of RNA | 9.019982e-01 | 0.045 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.028382e-01 | 0.044 |
| R-HSA-72312 | rRNA processing | 9.046477e-01 | 0.044 |
| R-HSA-15869 | Metabolism of nucleotides | 9.081668e-01 | 0.042 |
| R-HSA-421270 | Cell-cell junction organization | 9.202521e-01 | 0.036 |
| R-HSA-416476 | G alpha (q) signalling events | 9.294393e-01 | 0.032 |
| R-HSA-9658195 | Leishmania infection | 9.398848e-01 | 0.027 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.398848e-01 | 0.027 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.442537e-01 | 0.025 |
| R-HSA-1483257 | Phospholipid metabolism | 9.473221e-01 | 0.024 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.478169e-01 | 0.023 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.725716e-01 | 0.012 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.801353e-01 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 9.848738e-01 | 0.007 |
| R-HSA-392499 | Metabolism of proteins | 9.924730e-01 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 9.953745e-01 | 0.002 |
| R-HSA-109582 | Hemostasis | 9.957545e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.958157e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.977413e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.994943e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.835 | 0.219 | 2 | 0.864 |
CLK3 |
0.834 | 0.228 | 1 | 0.840 |
GRK1 |
0.828 | 0.267 | -2 | 0.828 |
MOS |
0.826 | 0.238 | 1 | 0.838 |
CDC7 |
0.825 | 0.183 | 1 | 0.819 |
PIM3 |
0.820 | 0.132 | -3 | 0.863 |
KIS |
0.819 | 0.151 | 1 | 0.696 |
NDR2 |
0.818 | 0.117 | -3 | 0.859 |
GSK3A |
0.817 | 0.375 | 4 | 0.684 |
RSK2 |
0.816 | 0.170 | -3 | 0.798 |
SRPK1 |
0.816 | 0.121 | -3 | 0.796 |
CLK2 |
0.815 | 0.218 | -3 | 0.791 |
BMPR1B |
0.814 | 0.229 | 1 | 0.801 |
GRK6 |
0.813 | 0.225 | 1 | 0.773 |
PIM1 |
0.812 | 0.141 | -3 | 0.822 |
GRK5 |
0.811 | 0.159 | -3 | 0.897 |
GSK3B |
0.811 | 0.344 | 4 | 0.679 |
GRK7 |
0.810 | 0.220 | 1 | 0.700 |
CAMK2G |
0.810 | 0.118 | 2 | 0.776 |
MTOR |
0.809 | 0.091 | 1 | 0.691 |
CAMK1B |
0.809 | 0.087 | -3 | 0.876 |
PRPK |
0.808 | -0.033 | -1 | 0.808 |
NLK |
0.808 | 0.085 | 1 | 0.788 |
SKMLCK |
0.807 | 0.099 | -2 | 0.845 |
IKKB |
0.806 | 0.012 | -2 | 0.713 |
CDKL1 |
0.806 | 0.080 | -3 | 0.831 |
HIPK4 |
0.806 | 0.092 | 1 | 0.819 |
NDR1 |
0.806 | 0.068 | -3 | 0.852 |
RAF1 |
0.806 | -0.016 | 1 | 0.733 |
CAMK2B |
0.805 | 0.164 | 2 | 0.782 |
P90RSK |
0.805 | 0.112 | -3 | 0.801 |
RSK4 |
0.805 | 0.161 | -3 | 0.778 |
CAMK2A |
0.803 | 0.181 | 2 | 0.792 |
PRKX |
0.803 | 0.164 | -3 | 0.730 |
RIPK3 |
0.802 | 0.004 | 3 | 0.544 |
ATR |
0.802 | 0.033 | 1 | 0.735 |
AURC |
0.802 | 0.095 | -2 | 0.655 |
CLK4 |
0.801 | 0.136 | -3 | 0.811 |
CDK1 |
0.801 | 0.132 | 1 | 0.679 |
ERK5 |
0.801 | 0.032 | 1 | 0.762 |
CK1E |
0.801 | 0.190 | -3 | 0.722 |
CDKL5 |
0.801 | 0.068 | -3 | 0.818 |
CAMLCK |
0.800 | 0.054 | -2 | 0.825 |
PASK |
0.800 | 0.280 | -3 | 0.882 |
P70S6KB |
0.800 | 0.085 | -3 | 0.815 |
DYRK2 |
0.800 | 0.116 | 1 | 0.747 |
SRPK2 |
0.800 | 0.087 | -3 | 0.722 |
PDHK4 |
0.800 | -0.088 | 1 | 0.751 |
SRPK3 |
0.799 | 0.075 | -3 | 0.777 |
GRK4 |
0.799 | 0.098 | -2 | 0.839 |
BMPR2 |
0.799 | -0.078 | -2 | 0.859 |
PKACB |
0.799 | 0.121 | -2 | 0.670 |
PKACG |
0.799 | 0.081 | -2 | 0.740 |
DSTYK |
0.799 | -0.025 | 2 | 0.861 |
MST4 |
0.798 | 0.016 | 2 | 0.851 |
GCN2 |
0.798 | -0.112 | 2 | 0.778 |
LATS1 |
0.798 | 0.128 | -3 | 0.860 |
WNK1 |
0.798 | 0.023 | -2 | 0.845 |
NUAK2 |
0.797 | 0.021 | -3 | 0.856 |
ICK |
0.797 | 0.083 | -3 | 0.856 |
TGFBR1 |
0.797 | 0.133 | -2 | 0.838 |
MSK1 |
0.797 | 0.132 | -3 | 0.778 |
PKN2 |
0.797 | 0.036 | -3 | 0.858 |
NIK |
0.797 | 0.009 | -3 | 0.884 |
BMPR1A |
0.797 | 0.186 | 1 | 0.781 |
CK2A2 |
0.797 | 0.171 | 1 | 0.740 |
DAPK2 |
0.797 | 0.044 | -3 | 0.875 |
RSK3 |
0.797 | 0.073 | -3 | 0.789 |
CK1D |
0.797 | 0.205 | -3 | 0.677 |
ALK2 |
0.796 | 0.160 | -2 | 0.852 |
CHAK2 |
0.796 | -0.014 | -1 | 0.791 |
PKN3 |
0.796 | -0.005 | -3 | 0.840 |
LATS2 |
0.795 | 0.035 | -5 | 0.731 |
MLK1 |
0.795 | -0.025 | 2 | 0.786 |
PRKD2 |
0.795 | 0.061 | -3 | 0.769 |
CK1A2 |
0.795 | 0.203 | -3 | 0.680 |
DLK |
0.795 | 0.085 | 1 | 0.726 |
ACVR2B |
0.795 | 0.143 | -2 | 0.811 |
ALK4 |
0.795 | 0.111 | -2 | 0.857 |
HIPK2 |
0.794 | 0.127 | 1 | 0.676 |
JNK2 |
0.794 | 0.134 | 1 | 0.634 |
TGFBR2 |
0.794 | -0.015 | -2 | 0.825 |
CAMK2D |
0.794 | 0.052 | -3 | 0.831 |
CK2A1 |
0.793 | 0.193 | 1 | 0.722 |
GRK2 |
0.793 | 0.107 | -2 | 0.726 |
CLK1 |
0.793 | 0.115 | -3 | 0.778 |
MYLK4 |
0.793 | 0.083 | -2 | 0.756 |
MAPKAPK2 |
0.793 | 0.066 | -3 | 0.745 |
MARK4 |
0.793 | -0.030 | 4 | 0.739 |
IKKA |
0.792 | 0.003 | -2 | 0.706 |
FAM20C |
0.792 | 0.043 | 2 | 0.541 |
TBK1 |
0.792 | -0.117 | 1 | 0.586 |
JNK3 |
0.792 | 0.117 | 1 | 0.666 |
IKKE |
0.792 | -0.099 | 1 | 0.588 |
MSK2 |
0.791 | 0.065 | -3 | 0.782 |
AMPKA1 |
0.791 | -0.010 | -3 | 0.858 |
ACVR2A |
0.791 | 0.110 | -2 | 0.797 |
PRKD1 |
0.790 | 0.001 | -3 | 0.820 |
ATM |
0.790 | -0.000 | 1 | 0.673 |
PKCD |
0.790 | 0.004 | 2 | 0.760 |
HIPK1 |
0.789 | 0.110 | 1 | 0.751 |
PKR |
0.789 | 0.045 | 1 | 0.783 |
CDK8 |
0.789 | 0.056 | 1 | 0.673 |
RIPK1 |
0.788 | -0.052 | 1 | 0.718 |
DYRK4 |
0.788 | 0.126 | 1 | 0.676 |
HUNK |
0.788 | -0.116 | 2 | 0.772 |
GRK3 |
0.788 | 0.127 | -2 | 0.702 |
CDK18 |
0.788 | 0.093 | 1 | 0.636 |
NEK6 |
0.788 | -0.102 | -2 | 0.840 |
MASTL |
0.787 | -0.115 | -2 | 0.794 |
PAK1 |
0.787 | 0.035 | -2 | 0.759 |
CDK7 |
0.787 | 0.051 | 1 | 0.690 |
CK1G1 |
0.787 | 0.146 | -3 | 0.721 |
MLK3 |
0.786 | -0.015 | 2 | 0.716 |
NEK7 |
0.786 | -0.136 | -3 | 0.815 |
P38B |
0.786 | 0.114 | 1 | 0.653 |
MAPKAPK3 |
0.786 | -0.004 | -3 | 0.776 |
TSSK2 |
0.786 | -0.023 | -5 | 0.812 |
AURB |
0.786 | 0.052 | -2 | 0.653 |
PLK1 |
0.786 | 0.031 | -2 | 0.791 |
MEK1 |
0.785 | 0.020 | 2 | 0.815 |
P38G |
0.785 | 0.100 | 1 | 0.590 |
P38A |
0.785 | 0.087 | 1 | 0.702 |
PDHK1 |
0.785 | -0.230 | 1 | 0.724 |
AMPKA2 |
0.784 | -0.010 | -3 | 0.830 |
ANKRD3 |
0.784 | -0.082 | 1 | 0.730 |
PKCB |
0.784 | 0.019 | 2 | 0.717 |
CDK19 |
0.783 | 0.053 | 1 | 0.642 |
CAMK4 |
0.783 | -0.024 | -3 | 0.836 |
PIM2 |
0.783 | 0.072 | -3 | 0.774 |
TSSK1 |
0.783 | -0.023 | -3 | 0.866 |
TTBK2 |
0.783 | -0.065 | 2 | 0.645 |
CDK10 |
0.783 | 0.119 | 1 | 0.657 |
AURA |
0.782 | 0.058 | -2 | 0.631 |
CDK17 |
0.782 | 0.085 | 1 | 0.598 |
ERK1 |
0.782 | 0.084 | 1 | 0.634 |
ULK2 |
0.782 | -0.224 | 2 | 0.733 |
CAMK1G |
0.782 | 0.058 | -3 | 0.780 |
DRAK1 |
0.782 | 0.060 | 1 | 0.687 |
CDK5 |
0.782 | 0.045 | 1 | 0.708 |
AKT2 |
0.781 | 0.070 | -3 | 0.729 |
QSK |
0.781 | -0.010 | 4 | 0.716 |
MLK2 |
0.781 | -0.114 | 2 | 0.796 |
TLK2 |
0.781 | 0.016 | 1 | 0.713 |
SMG1 |
0.781 | 0.040 | 1 | 0.684 |
CDK13 |
0.781 | 0.045 | 1 | 0.664 |
IRE1 |
0.781 | -0.084 | 1 | 0.743 |
PKCG |
0.781 | -0.006 | 2 | 0.702 |
CDK3 |
0.780 | 0.072 | 1 | 0.617 |
CDK14 |
0.780 | 0.093 | 1 | 0.665 |
JNK1 |
0.779 | 0.117 | 1 | 0.638 |
MARK3 |
0.779 | 0.006 | 4 | 0.693 |
MLK4 |
0.779 | -0.032 | 2 | 0.704 |
CDK2 |
0.779 | 0.035 | 1 | 0.730 |
YSK4 |
0.779 | -0.031 | 1 | 0.645 |
BCKDK |
0.779 | -0.166 | -1 | 0.717 |
MEKK3 |
0.779 | 0.041 | 1 | 0.684 |
PKG2 |
0.778 | 0.038 | -2 | 0.668 |
DYRK3 |
0.778 | 0.092 | 1 | 0.759 |
DNAPK |
0.778 | 0.039 | 1 | 0.573 |
PLK3 |
0.778 | 0.008 | 2 | 0.726 |
VRK2 |
0.778 | -0.119 | 1 | 0.786 |
MNK1 |
0.778 | 0.009 | -2 | 0.767 |
PKCA |
0.777 | -0.010 | 2 | 0.702 |
ERK2 |
0.777 | 0.062 | 1 | 0.678 |
WNK3 |
0.777 | -0.208 | 1 | 0.696 |
NEK9 |
0.777 | -0.168 | 2 | 0.806 |
DYRK1A |
0.777 | 0.069 | 1 | 0.734 |
CDK12 |
0.776 | 0.052 | 1 | 0.639 |
PAK3 |
0.776 | -0.033 | -2 | 0.750 |
BRSK1 |
0.776 | -0.020 | -3 | 0.806 |
QIK |
0.776 | -0.074 | -3 | 0.839 |
NIM1 |
0.776 | -0.085 | 3 | 0.556 |
PKACA |
0.776 | 0.082 | -2 | 0.619 |
CDK16 |
0.776 | 0.096 | 1 | 0.611 |
SGK3 |
0.776 | 0.036 | -3 | 0.795 |
GAK |
0.776 | 0.136 | 1 | 0.748 |
PRP4 |
0.776 | 0.053 | -3 | 0.796 |
PRKD3 |
0.775 | 0.000 | -3 | 0.767 |
PAK2 |
0.775 | -0.017 | -2 | 0.746 |
MST3 |
0.775 | 0.052 | 2 | 0.811 |
DYRK1B |
0.775 | 0.075 | 1 | 0.696 |
CDK9 |
0.775 | 0.035 | 1 | 0.664 |
MNK2 |
0.774 | -0.024 | -2 | 0.760 |
PKCZ |
0.774 | -0.040 | 2 | 0.745 |
PKCH |
0.774 | -0.022 | 2 | 0.680 |
TLK1 |
0.773 | -0.014 | -2 | 0.835 |
SIK |
0.773 | -0.020 | -3 | 0.780 |
DAPK1 |
0.773 | 0.107 | -3 | 0.824 |
MARK2 |
0.773 | -0.035 | 4 | 0.664 |
MELK |
0.772 | -0.057 | -3 | 0.809 |
ULK1 |
0.772 | -0.200 | -3 | 0.771 |
DCAMKL1 |
0.772 | 0.022 | -3 | 0.801 |
NUAK1 |
0.772 | -0.054 | -3 | 0.799 |
P38D |
0.772 | 0.091 | 1 | 0.591 |
CK1A |
0.770 | 0.197 | -3 | 0.602 |
HIPK3 |
0.770 | 0.044 | 1 | 0.708 |
SMMLCK |
0.770 | 0.018 | -3 | 0.839 |
PAK6 |
0.770 | 0.004 | -2 | 0.676 |
TAO3 |
0.769 | -0.002 | 1 | 0.680 |
MEK5 |
0.769 | -0.115 | 2 | 0.789 |
DAPK3 |
0.769 | 0.061 | -3 | 0.828 |
BRSK2 |
0.768 | -0.074 | -3 | 0.818 |
MARK1 |
0.768 | -0.047 | 4 | 0.699 |
IRE2 |
0.768 | -0.128 | 2 | 0.670 |
PERK |
0.768 | -0.110 | -2 | 0.838 |
P70S6K |
0.768 | 0.031 | -3 | 0.732 |
CHAK1 |
0.767 | -0.140 | 2 | 0.694 |
MEKK2 |
0.766 | -0.074 | 2 | 0.768 |
CHK1 |
0.766 | -0.066 | -3 | 0.796 |
BRAF |
0.766 | -0.088 | -4 | 0.756 |
PLK2 |
0.766 | 0.072 | -3 | 0.784 |
PHKG1 |
0.766 | -0.094 | -3 | 0.839 |
MPSK1 |
0.765 | -0.012 | 1 | 0.722 |
CAMK1D |
0.765 | 0.035 | -3 | 0.715 |
MAK |
0.764 | 0.113 | -2 | 0.726 |
AKT1 |
0.763 | 0.034 | -3 | 0.741 |
ZAK |
0.763 | -0.109 | 1 | 0.648 |
GCK |
0.762 | 0.053 | 1 | 0.697 |
MAPKAPK5 |
0.762 | -0.058 | -3 | 0.730 |
SSTK |
0.762 | -0.036 | 4 | 0.686 |
SGK1 |
0.762 | 0.081 | -3 | 0.661 |
MEKK1 |
0.762 | -0.172 | 1 | 0.677 |
WNK4 |
0.761 | -0.119 | -2 | 0.839 |
MRCKA |
0.761 | 0.083 | -3 | 0.782 |
NEK2 |
0.761 | -0.168 | 2 | 0.772 |
TAK1 |
0.761 | 0.076 | 1 | 0.708 |
DCAMKL2 |
0.760 | -0.019 | -3 | 0.814 |
NEK5 |
0.760 | -0.136 | 1 | 0.712 |
ROCK2 |
0.760 | 0.066 | -3 | 0.818 |
MOK |
0.760 | 0.087 | 1 | 0.775 |
SNRK |
0.759 | -0.167 | 2 | 0.602 |
PKCE |
0.759 | 0.011 | 2 | 0.677 |
PINK1 |
0.759 | -0.155 | 1 | 0.805 |
HRI |
0.759 | -0.189 | -2 | 0.827 |
HPK1 |
0.758 | 0.041 | 1 | 0.679 |
NEK11 |
0.758 | -0.079 | 1 | 0.662 |
MRCKB |
0.758 | 0.056 | -3 | 0.769 |
ERK7 |
0.758 | 0.024 | 2 | 0.548 |
AKT3 |
0.757 | 0.060 | -3 | 0.673 |
PKCI |
0.757 | -0.035 | 2 | 0.711 |
PLK4 |
0.755 | -0.148 | 2 | 0.569 |
EEF2K |
0.755 | -0.042 | 3 | 0.583 |
PKCT |
0.755 | -0.067 | 2 | 0.696 |
DMPK1 |
0.755 | 0.092 | -3 | 0.792 |
MST2 |
0.755 | -0.047 | 1 | 0.688 |
CDK4 |
0.754 | 0.038 | 1 | 0.636 |
IRAK4 |
0.754 | -0.155 | 1 | 0.714 |
CAMKK1 |
0.753 | -0.135 | -2 | 0.716 |
CDK6 |
0.753 | 0.030 | 1 | 0.635 |
LKB1 |
0.753 | -0.100 | -3 | 0.811 |
YANK3 |
0.753 | 0.050 | 2 | 0.371 |
TAO2 |
0.752 | -0.116 | 2 | 0.808 |
LRRK2 |
0.752 | -0.066 | 2 | 0.795 |
CAMKK2 |
0.752 | -0.097 | -2 | 0.711 |
NEK8 |
0.752 | -0.147 | 2 | 0.760 |
PAK5 |
0.752 | -0.016 | -2 | 0.623 |
PDK1 |
0.751 | -0.097 | 1 | 0.668 |
VRK1 |
0.751 | -0.088 | 2 | 0.775 |
TTBK1 |
0.751 | -0.116 | 2 | 0.548 |
PAK4 |
0.751 | -0.001 | -2 | 0.632 |
KHS2 |
0.750 | 0.006 | 1 | 0.685 |
TNIK |
0.749 | -0.082 | 3 | 0.604 |
STK33 |
0.749 | -0.049 | 2 | 0.568 |
CHK2 |
0.749 | 0.008 | -3 | 0.676 |
PDHK3_TYR |
0.749 | 0.263 | 4 | 0.794 |
SLK |
0.749 | -0.042 | -2 | 0.686 |
CAMK1A |
0.748 | 0.015 | -3 | 0.689 |
HASPIN |
0.748 | 0.038 | -1 | 0.681 |
PDHK4_TYR |
0.747 | 0.258 | 2 | 0.845 |
MINK |
0.746 | -0.097 | 1 | 0.669 |
CK1G3 |
0.746 | 0.174 | -3 | 0.561 |
PHKG2 |
0.745 | -0.115 | -3 | 0.813 |
LOK |
0.745 | -0.077 | -2 | 0.731 |
HGK |
0.745 | -0.116 | 3 | 0.606 |
MST1 |
0.744 | -0.084 | 1 | 0.671 |
SBK |
0.744 | 0.044 | -3 | 0.602 |
KHS1 |
0.744 | -0.049 | 1 | 0.664 |
ROCK1 |
0.743 | 0.042 | -3 | 0.784 |
BUB1 |
0.743 | 0.004 | -5 | 0.758 |
CK1G2 |
0.743 | 0.179 | -3 | 0.646 |
ALPHAK3 |
0.742 | 0.058 | -1 | 0.737 |
BMPR2_TYR |
0.742 | 0.173 | -1 | 0.845 |
MAP2K6_TYR |
0.742 | 0.192 | -1 | 0.823 |
IRAK1 |
0.742 | -0.259 | -1 | 0.695 |
TTK |
0.742 | -0.018 | -2 | 0.824 |
CRIK |
0.742 | 0.061 | -3 | 0.732 |
MEKK6 |
0.741 | -0.171 | 1 | 0.668 |
OSR1 |
0.741 | -0.034 | 2 | 0.806 |
NEK4 |
0.741 | -0.196 | 1 | 0.671 |
MAP3K15 |
0.739 | -0.168 | 1 | 0.621 |
PKN1 |
0.739 | -0.054 | -3 | 0.746 |
NEK1 |
0.738 | -0.180 | 1 | 0.682 |
MAP2K4_TYR |
0.738 | 0.117 | -1 | 0.828 |
PDHK1_TYR |
0.738 | 0.150 | -1 | 0.844 |
PBK |
0.736 | -0.072 | 1 | 0.656 |
YSK1 |
0.735 | -0.125 | 2 | 0.778 |
TESK1_TYR |
0.735 | -0.015 | 3 | 0.636 |
MEK2 |
0.735 | -0.212 | 2 | 0.776 |
PKG1 |
0.731 | -0.019 | -2 | 0.581 |
TXK |
0.731 | 0.098 | 1 | 0.771 |
MAP2K7_TYR |
0.730 | -0.073 | 2 | 0.800 |
RIPK2 |
0.730 | -0.239 | 1 | 0.588 |
PKMYT1_TYR |
0.729 | -0.094 | 3 | 0.617 |
EPHA6 |
0.726 | -0.017 | -1 | 0.839 |
MYO3B |
0.726 | -0.095 | 2 | 0.775 |
PINK1_TYR |
0.724 | -0.143 | 1 | 0.750 |
YANK2 |
0.723 | 0.041 | 2 | 0.385 |
BIKE |
0.723 | -0.063 | 1 | 0.622 |
LIMK2_TYR |
0.723 | -0.078 | -3 | 0.867 |
EPHB4 |
0.722 | -0.047 | -1 | 0.812 |
MYO3A |
0.722 | -0.116 | 1 | 0.705 |
EPHA4 |
0.721 | 0.017 | 2 | 0.730 |
SRMS |
0.717 | -0.021 | 1 | 0.765 |
FGR |
0.716 | -0.064 | 1 | 0.732 |
YES1 |
0.716 | -0.069 | -1 | 0.829 |
ASK1 |
0.715 | -0.207 | 1 | 0.610 |
FER |
0.714 | -0.100 | 1 | 0.775 |
RET |
0.714 | -0.205 | 1 | 0.678 |
NEK3 |
0.714 | -0.265 | 1 | 0.611 |
TAO1 |
0.714 | -0.171 | 1 | 0.588 |
LIMK1_TYR |
0.713 | -0.221 | 2 | 0.785 |
ABL2 |
0.713 | -0.114 | -1 | 0.784 |
INSRR |
0.713 | -0.098 | 3 | 0.520 |
FYN |
0.712 | 0.023 | -1 | 0.817 |
STLK3 |
0.712 | -0.147 | 1 | 0.614 |
PTK2 |
0.712 | 0.086 | -1 | 0.794 |
BLK |
0.712 | -0.034 | -1 | 0.835 |
DDR1 |
0.712 | -0.151 | 4 | 0.704 |
EPHB1 |
0.711 | -0.071 | 1 | 0.741 |
SYK |
0.711 | 0.119 | -1 | 0.772 |
FLT1 |
0.710 | -0.008 | -1 | 0.799 |
MST1R |
0.710 | -0.253 | 3 | 0.561 |
ABL1 |
0.710 | -0.108 | -1 | 0.777 |
LCK |
0.709 | -0.080 | -1 | 0.830 |
BMX |
0.709 | -0.033 | -1 | 0.738 |
ITK |
0.709 | -0.078 | -1 | 0.783 |
EPHB3 |
0.709 | -0.094 | -1 | 0.796 |
EPHB2 |
0.709 | -0.064 | -1 | 0.796 |
TNK2 |
0.708 | -0.114 | 3 | 0.527 |
TYRO3 |
0.708 | -0.235 | 3 | 0.542 |
FGFR2 |
0.707 | -0.130 | 3 | 0.583 |
CSF1R |
0.707 | -0.208 | 3 | 0.538 |
TEC |
0.707 | -0.056 | -1 | 0.739 |
KDR |
0.706 | -0.134 | 3 | 0.523 |
HCK |
0.706 | -0.133 | -1 | 0.826 |
EPHA7 |
0.705 | -0.055 | 2 | 0.727 |
MET |
0.705 | -0.105 | 3 | 0.543 |
KIT |
0.705 | -0.149 | 3 | 0.547 |
AAK1 |
0.705 | -0.041 | 1 | 0.529 |
ROS1 |
0.705 | -0.272 | 3 | 0.522 |
JAK3 |
0.705 | -0.185 | 1 | 0.650 |
DDR2 |
0.703 | -0.041 | 3 | 0.522 |
TYK2 |
0.702 | -0.358 | 1 | 0.668 |
JAK2 |
0.702 | -0.316 | 1 | 0.657 |
TEK |
0.702 | -0.184 | 3 | 0.501 |
EPHA3 |
0.701 | -0.088 | 2 | 0.697 |
EPHA5 |
0.701 | -0.037 | 2 | 0.714 |
MERTK |
0.701 | -0.125 | 3 | 0.544 |
FGFR3 |
0.700 | -0.106 | 3 | 0.556 |
ERBB2 |
0.699 | -0.126 | 1 | 0.647 |
WEE1_TYR |
0.699 | -0.095 | -1 | 0.708 |
EPHA8 |
0.699 | -0.062 | -1 | 0.796 |
PTK2B |
0.698 | -0.058 | -1 | 0.751 |
FRK |
0.696 | -0.120 | -1 | 0.837 |
SRC |
0.696 | -0.067 | -1 | 0.809 |
NEK10_TYR |
0.696 | -0.161 | 1 | 0.544 |
AXL |
0.695 | -0.196 | 3 | 0.538 |
PTK6 |
0.695 | -0.175 | -1 | 0.697 |
TNK1 |
0.695 | -0.205 | 3 | 0.540 |
LYN |
0.694 | -0.130 | 3 | 0.499 |
MATK |
0.693 | -0.110 | -1 | 0.705 |
LTK |
0.693 | -0.180 | 3 | 0.520 |
FLT3 |
0.693 | -0.264 | 3 | 0.536 |
FGFR1 |
0.693 | -0.248 | 3 | 0.531 |
BTK |
0.693 | -0.200 | -1 | 0.758 |
NTRK1 |
0.692 | -0.211 | -1 | 0.763 |
PDGFRB |
0.692 | -0.292 | 3 | 0.549 |
EPHA2 |
0.692 | -0.052 | -1 | 0.774 |
ERBB4 |
0.692 | -0.020 | 1 | 0.612 |
EGFR |
0.691 | -0.066 | 1 | 0.555 |
EPHA1 |
0.691 | -0.182 | 3 | 0.524 |
ALK |
0.691 | -0.228 | 3 | 0.489 |
FLT4 |
0.690 | -0.191 | 3 | 0.542 |
FGFR4 |
0.690 | -0.077 | -1 | 0.740 |
TNNI3K_TYR |
0.688 | -0.212 | 1 | 0.707 |
JAK1 |
0.686 | -0.247 | 1 | 0.589 |
NTRK3 |
0.686 | -0.175 | -1 | 0.721 |
INSR |
0.685 | -0.218 | 3 | 0.505 |
ZAP70 |
0.685 | 0.016 | -1 | 0.692 |
CSK |
0.684 | -0.147 | 2 | 0.723 |
PDGFRA |
0.683 | -0.353 | 3 | 0.543 |
NTRK2 |
0.680 | -0.280 | 3 | 0.509 |
IGF1R |
0.678 | -0.158 | 3 | 0.467 |
FES |
0.670 | -0.124 | -1 | 0.702 |
MUSK |
0.664 | -0.211 | 1 | 0.542 |