Motif 458 (n=294)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A1L170	C1orf226	S240	ochoa	Uncharacterized protein C1orf226	None
A2RU67	FAM234B	S33	ochoa	Protein FAM234B	None
A3KN83	SBNO1	S840	ochoa	Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3)	Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250\|UniProtKB:Q689Z5}.
A6NKT7	RGPD3	S1322	ochoa	RanBP2-like and GRIP domain-containing protein 3	None
A7KAX9	ARHGAP32	S1220	ochoa	Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)	GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12446789, ECO:0000269\|PubMed:12454018, ECO:0000269\|PubMed:12531901, ECO:0000269\|PubMed:12788081, ECO:0000269\|PubMed:12819203, ECO:0000269\|PubMed:12857875, ECO:0000269\|PubMed:17663722}.
C9JLW8	MCRIP1	S21	ochoa\|psp	Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B)	The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269\|PubMed:25728771}.
E7EW31	PROB1	S277	ochoa	Proline-rich basic protein 1	None
H0Y626	None	S48	ochoa	RING-type E3 ubiquitin transferase (EC 2.3.2.27)	None
O00268	TAF4	S560	ochoa	Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135)	The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269\|PubMed:10594036, ECO:0000269\|PubMed:33795473, ECO:0000269\|PubMed:8942982, ECO:0000269\|PubMed:9192867}.
O00299	CLIC1	S163	ochoa	Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC)	In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269\|PubMed:10834939, ECO:0000269\|PubMed:10874038, ECO:0000269\|PubMed:11195932, ECO:0000269\|PubMed:11551966, ECO:0000269\|PubMed:11940526, ECO:0000269\|PubMed:11978800, ECO:0000269\|PubMed:14613939, ECO:0000269\|PubMed:16339885, ECO:0000269\|PubMed:25581026, ECO:0000269\|PubMed:37759794, ECO:0000269\|PubMed:9139710}.
O14686	KMT2D	S2431	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O14920	IKBKB	S689	ochoa	Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250\|UniProtKB:O88351, ECO:0000269\|PubMed:11297557, ECO:0000269\|PubMed:14673179, ECO:0000269\|PubMed:15084260, ECO:0000269\|PubMed:17213322, ECO:0000269\|PubMed:19716809, ECO:0000269\|PubMed:20410276, ECO:0000269\|PubMed:20434986, ECO:0000269\|PubMed:20797629, ECO:0000269\|PubMed:21138416, ECO:0000269\|PubMed:25326418, ECO:0000269\|PubMed:30337470, ECO:0000269\|PubMed:32209697, ECO:0000269\|PubMed:38621137, ECO:0000269\|PubMed:9346484}.
O14994	SYN3	S492	ochoa	Synapsin-3 (Synapsin III)	May be involved in the regulation of neurotransmitter release and synaptogenesis.
O15553	MEFV	S366	ochoa	Pyrin (Marenostrin)	Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:16037825, PubMed:16785446, PubMed:17431422, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:26347139, PubMed:27030597, PubMed:28835462). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). {ECO:0000250\|UniProtKB:Q9JJ26, ECO:0000269\|PubMed:10807793, ECO:0000269\|PubMed:11468188, ECO:0000269\|PubMed:16037825, ECO:0000269\|PubMed:16785446, ECO:0000269\|PubMed:17431422, ECO:0000269\|PubMed:17964261, ECO:0000269\|PubMed:18577712, ECO:0000269\|PubMed:19109554, ECO:0000269\|PubMed:19584923, ECO:0000269\|PubMed:26347139, ECO:0000269\|PubMed:27030597, ECO:0000269\|PubMed:28835462}.
O43166	SIPA1L1	S210	ochoa	Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)	Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43167	ZBTB24	S151	ochoa	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450)	May be involved in BMP2-induced transcription. {ECO:0000250}.
O43182	ARHGAP6	S363	ochoa	Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269\|PubMed:10699171}.
O43521	BCL2L11	S94	ochoa\|psp	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269\|PubMed:11997495, ECO:0000269\|PubMed:15486195, ECO:0000269\|PubMed:15661735, ECO:0000269\|PubMed:9430630}.
O43524	FOXO3	S311	ochoa	Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)	Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250\|UniProtKB:Q9WVH4, ECO:0000269\|PubMed:10102273, ECO:0000269\|PubMed:16751106, ECO:0000269\|PubMed:21329882, ECO:0000269\|PubMed:23283301, ECO:0000269\|PubMed:30513302}.
O43524	FOXO3	S442	ochoa	Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)	Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250\|UniProtKB:Q9WVH4, ECO:0000269\|PubMed:10102273, ECO:0000269\|PubMed:16751106, ECO:0000269\|PubMed:21329882, ECO:0000269\|PubMed:23283301, ECO:0000269\|PubMed:30513302}.
O43561	LAT	S101	ochoa	Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)	Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269\|PubMed:10072481, ECO:0000269\|PubMed:23514740, ECO:0000269\|PubMed:25907557}.
O60271	SPAG9	S268	ochoa	C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250\|UniProtKB:Q58A65, ECO:0000269\|PubMed:14743216, ECO:0000269\|PubMed:29146937}.
O60885	BRD4	S1100	ochoa	Bromodomain-containing protein 4 (Protein HUNK1)	Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250\|UniProtKB:Q9ESU6, ECO:0000269\|PubMed:16109376, ECO:0000269\|PubMed:16109377, ECO:0000269\|PubMed:19103749, ECO:0000269\|PubMed:19596240, ECO:0000269\|PubMed:22334664, ECO:0000269\|PubMed:22509028, ECO:0000269\|PubMed:23086925, ECO:0000269\|PubMed:23317504, ECO:0000269\|PubMed:23589332, ECO:0000269\|PubMed:24360279, ECO:0000269\|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269\|PubMed:23728299}.
O60941	DTNB	S552	ochoa	Dystrobrevin beta (DTN-B) (Beta-dystrobrevin)	Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250\|UniProtKB:O70585, ECO:0000269\|PubMed:27223470}.
O75152	ZC3H11A	S149	ochoa	Zinc finger CCCH domain-containing protein 11A	Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269\|PubMed:22928037, ECO:0000269\|PubMed:29610341, ECO:0000269\|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269\|PubMed:29610341, ECO:0000269\|PubMed:37356722}.
O75376	NCOR1	Y2101	ochoa	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250\|UniProtKB:Q60974, ECO:0000269\|PubMed:14527417, ECO:0000269\|PubMed:20812024}.
O75381	PEX14	S282	ochoa	Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)	Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250\|UniProtKB:P53112, ECO:0000269\|PubMed:21525035, ECO:0000269\|PubMed:24235149, ECO:0000269\|PubMed:28765278, ECO:0000269\|PubMed:9653144}.
O75385	ULK1	S539	ochoa	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)	Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269\|PubMed:11146101, ECO:0000269\|PubMed:18936157, ECO:0000269\|PubMed:20921139, ECO:0000269\|PubMed:21460634, ECO:0000269\|PubMed:21795849, ECO:0000269\|PubMed:23524951, ECO:0000269\|PubMed:25040165, ECO:0000269\|PubMed:25126726, ECO:0000269\|PubMed:28821708, ECO:0000269\|PubMed:29487085, ECO:0000269\|PubMed:31123703, ECO:0000269\|PubMed:37306101}.
O75864	PPP1R37	S561	ochoa	Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68)	Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269\|PubMed:19389623}.
O76021	RSL1D1	S413	ochoa	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269\|PubMed:18678645, ECO:0000269\|PubMed:22419112}.
O76039	CDKL5	S394	ochoa	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)	Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269\|PubMed:15917271, ECO:0000269\|PubMed:16935860, ECO:0000269\|PubMed:29420175}.
O94804	STK10	S455	ochoa	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)	Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269\|PubMed:11903060, ECO:0000269\|PubMed:12639966, ECO:0000269\|PubMed:19255442}.
O94806	PRKD3	S44	ochoa	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)	Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
O94811	TPPP	S35	ochoa	Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)	Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269\|PubMed:17105200, ECO:0000269\|PubMed:17693641, ECO:0000269\|PubMed:18028908, ECO:0000269\|PubMed:20308065, ECO:0000269\|PubMed:21316364, ECO:0000269\|PubMed:21995432, ECO:0000269\|PubMed:22328514, ECO:0000269\|PubMed:23093407, ECO:0000269\|PubMed:23355470, ECO:0000269\|PubMed:26289831, ECO:0000269\|PubMed:31522887}.
O94887	FARP2	S427	ochoa	FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)	Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O94929	ABLIM3	S493	ochoa	Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3)	May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269\|PubMed:17194709}.
O95197	RTN3	S246	ochoa	Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)	May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269\|PubMed:15286784, ECO:0000269\|PubMed:16054885, ECO:0000269\|PubMed:17031492, ECO:0000269\|PubMed:17191123, ECO:0000269\|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269\|PubMed:17182608}.
O95267	RASGRP1	S711	ochoa	RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein)	Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332). {ECO:0000250\|UniProtKB:Q9Z1S3, ECO:0000269\|PubMed:10807788, ECO:0000269\|PubMed:12782630, ECO:0000269\|PubMed:12839994, ECO:0000269\|PubMed:12845332, ECO:0000269\|PubMed:15060167, ECO:0000269\|PubMed:15184873, ECO:0000269\|PubMed:15899849, ECO:0000269\|PubMed:19933860, ECO:0000269\|PubMed:23908768, ECO:0000269\|PubMed:27776107, ECO:0000269\|PubMed:29155103}.
O95361	TRIM16	S48	ochoa	Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein)	E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269\|PubMed:22629402, ECO:0000269\|PubMed:27693506, ECO:0000269\|PubMed:30143514}.
O95425	SVIL	S238	ochoa\|psp	Supervillin (Archvillin) (p205/p250)	[Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269\|PubMed:12711699, ECO:0000269\|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250\|UniProtKB:O46385}.
O95835	LATS1	S221	ochoa	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269\|PubMed:10518011, ECO:0000269\|PubMed:10831611, ECO:0000269\|PubMed:15122335, ECO:0000269\|PubMed:15220930, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:19927127, ECO:0000269\|PubMed:26437443, ECO:0000269\|PubMed:28068668, ECO:0000269\|PubMed:39173637, ECO:0000269\|PubMed:9988268}.
P02545	LMNA	T409	ochoa	Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	[Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269\|PubMed:10080180, ECO:0000269\|PubMed:10580070, ECO:0000269\|PubMed:10587585, ECO:0000269\|PubMed:10814726, ECO:0000269\|PubMed:11799477, ECO:0000269\|PubMed:12075506, ECO:0000269\|PubMed:12927431, ECO:0000269\|PubMed:15317753, ECO:0000269\|PubMed:18551513, ECO:0000269\|PubMed:18611980, ECO:0000269\|PubMed:2188730, ECO:0000269\|PubMed:22431096, ECO:0000269\|PubMed:2344612, ECO:0000269\|PubMed:23666920, ECO:0000269\|PubMed:23990565, ECO:0000269\|PubMed:24741066, ECO:0000269\|PubMed:25127216, ECO:0000269\|PubMed:31434876, ECO:0000269\|PubMed:31548606, ECO:0000269\|PubMed:37788673, ECO:0000269\|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269\|PubMed:20458013}.
P02671	FGA	S551	ochoa	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250\|UniProtKB:E9PV24}.
P04049	RAF1	S306	ochoa	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)	Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269\|PubMed:11427728, ECO:0000269\|PubMed:11719507, ECO:0000269\|PubMed:15385642, ECO:0000269\|PubMed:15618521, ECO:0000269\|PubMed:15849194, ECO:0000269\|PubMed:16892053, ECO:0000269\|PubMed:16924233, ECO:0000269\|PubMed:9360956}.
P08651	NFIC	S322	ochoa	Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
P08670	VIM	S73	ochoa\|psp	Vimentin	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250\|UniProtKB:A0A8C0N8E3, ECO:0000250\|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269\|PubMed:21746880}.
P0DJD0	RGPD1	S1306	ochoa	RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)	None
P0DJD1	RGPD2	S1314	ochoa	RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2)	None
P11362	FGFR1	S794	ochoa	Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)	Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250\|UniProtKB:P16092, ECO:0000269\|PubMed:10830168, ECO:0000269\|PubMed:11353842, ECO:0000269\|PubMed:12181353, ECO:0000269\|PubMed:1379697, ECO:0000269\|PubMed:1379698, ECO:0000269\|PubMed:15117958, ECO:0000269\|PubMed:16597617, ECO:0000269\|PubMed:17311277, ECO:0000269\|PubMed:17623664, ECO:0000269\|PubMed:18480409, ECO:0000269\|PubMed:19224897, ECO:0000269\|PubMed:19261810, ECO:0000269\|PubMed:19665973, ECO:0000269\|PubMed:20133753, ECO:0000269\|PubMed:20139426, ECO:0000269\|PubMed:21765395, ECO:0000269\|PubMed:8622701, ECO:0000269\|PubMed:8663044}.
P14635	CCNB1	S133	psp	G2/mitotic-specific cyclin-B1	Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269\|PubMed:17495531, ECO:0000269\|PubMed:17495533, ECO:0000269\|PubMed:27030811}.
P15408	FOSL2	S211	ochoa	Fos-related antigen 2 (FRA-2)	Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250\|UniProtKB:P47930, ECO:0000250\|UniProtKB:P51145}.
P15923	TCF3	S156	ochoa	Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)	Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250\|UniProtKB:P15806, ECO:0000269\|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269\|PubMed:31696227}.
P17302	GJA1	S296	ochoa	Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250\|UniProtKB:P08050, ECO:0000250\|UniProtKB:P23242}.
P19338	NCL	S580	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19634	SLC9A1	S788	ochoa	Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)	Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250\|UniProtKB:P26431, ECO:0000269\|PubMed:11350981, ECO:0000269\|PubMed:11532004, ECO:0000269\|PubMed:12947095, ECO:0000269\|PubMed:14680478, ECO:0000269\|PubMed:15035633, ECO:0000269\|PubMed:15096511, ECO:0000269\|PubMed:15677483, ECO:0000269\|PubMed:17073455, ECO:0000269\|PubMed:17493937, ECO:0000269\|PubMed:22020933, ECO:0000269\|PubMed:27650500, ECO:0000269\|PubMed:32130622, ECO:0000269\|PubMed:7110335, ECO:0000269\|PubMed:7603840, ECO:0000269\|PubMed:8901634}.
P19793	RXRA	S66	psp	Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)	Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:16107141, PubMed:17761950, PubMed:18800767, PubMed:19167885, PubMed:28167758, PubMed:37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:37478846, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632). {ECO:0000269\|PubMed:10195690, ECO:0000269\|PubMed:10874028, ECO:0000269\|PubMed:11162439, ECO:0000269\|PubMed:11915042, ECO:0000269\|PubMed:12145331, ECO:0000269\|PubMed:1310260, ECO:0000269\|PubMed:15509776, ECO:0000269\|PubMed:16107141, ECO:0000269\|PubMed:17761950, ECO:0000269\|PubMed:18800767, ECO:0000269\|PubMed:19167885, ECO:0000269\|PubMed:20215566, ECO:0000269\|PubMed:25417649, ECO:0000269\|PubMed:26463675, ECO:0000269\|PubMed:28167758, ECO:0000269\|PubMed:29021580, ECO:0000269\|PubMed:30216632, ECO:0000269\|PubMed:37478846, ECO:0000269\|PubMed:9267036}.
P20700	LMNB1	S408	ochoa	Lamin-B1	Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269\|PubMed:28716252, ECO:0000269\|PubMed:32910914}.
P22681	CBL	S669	ochoa	E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)	E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250\|UniProtKB:P22682, ECO:0000269\|PubMed:10514377, ECO:0000269\|PubMed:11896602, ECO:0000269\|PubMed:14661060, ECO:0000269\|PubMed:14739300, ECO:0000269\|PubMed:15190072, ECO:0000269\|PubMed:17094949, ECO:0000269\|PubMed:17509076, ECO:0000269\|PubMed:17974561, ECO:0000269\|PubMed:18374639, ECO:0000269\|PubMed:19689429, ECO:0000269\|PubMed:21596750, ECO:0000269\|PubMed:28381567}.
P27816	MAP4	S116	ochoa	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P27816	MAP4	S713	ochoa	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P29590	PML	S547	ochoa	Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)	Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269\|PubMed:11500381, ECO:0000269\|PubMed:11575918, ECO:0000269\|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269\|PubMed:20972456, ECO:0000269\|PubMed:28250117}.
P30260	CDC27	S386	ochoa	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
P30260	CDC27	S387	ochoa	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
P35251	RFC1	S173	ochoa	Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)	Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269\|PubMed:8999859, ECO:0000269\|PubMed:9488738}.
P35568	IRS1	S362	psp	Insulin receptor substrate 1 (IRS-1)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:11171109, ECO:0000269\|PubMed:16878150, ECO:0000269\|PubMed:19639489, ECO:0000269\|PubMed:38625937, ECO:0000269\|PubMed:7541045, ECO:0000269\|PubMed:8265614}.
P35711	SOX5	S126	ochoa	Transcription factor SOX-5	Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250\|UniProtKB:P35710}.
P38398	BRCA1	S1514	ochoa	Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)	E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269\|PubMed:10500182, ECO:0000269\|PubMed:10724175, ECO:0000269\|PubMed:11836499, ECO:0000269\|PubMed:12183412, ECO:0000269\|PubMed:12887909, ECO:0000269\|PubMed:12890688, ECO:0000269\|PubMed:14976165, ECO:0000269\|PubMed:16326698, ECO:0000269\|PubMed:16818604, ECO:0000269\|PubMed:17525340, ECO:0000269\|PubMed:18056443, ECO:0000269\|PubMed:19261748, ECO:0000269\|PubMed:19369211, ECO:0000269\|PubMed:20160719, ECO:0000269\|PubMed:20351172}.
P42331	ARHGAP25	S379	ochoa\|psp	Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
P42684	ABL2	S953	ochoa	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250\|UniProtKB:Q4JIM5, ECO:0000269\|PubMed:15735735, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:18945674}.
P43243	MATR3	S615	ochoa	Matrin-3	May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269\|PubMed:11525732, ECO:0000269\|PubMed:28431233, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:32245947}.
P43243	MATR3	S621	ochoa	Matrin-3	May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269\|PubMed:11525732, ECO:0000269\|PubMed:28431233, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:32245947}.
P46013	MKI67	S325	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	S374	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46821	MAP1B	S1171	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P46821	MAP1B	S1339	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P46821	MAP1B	S1406	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P48651	PTDSS1	S442	ochoa	Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)	Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269\|PubMed:19014349, ECO:0000269\|PubMed:24241535}.
P49023	PXN	S261	ochoa	Paxillin	Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269\|PubMed:25015296}.
P49450	CENPA	S36	ochoa	Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)	Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269\|PubMed:11756469, ECO:0000269\|PubMed:14667408, ECO:0000269\|PubMed:15282608, ECO:0000269\|PubMed:15475964, ECO:0000269\|PubMed:15702419, ECO:0000269\|PubMed:17651496, ECO:0000269\|PubMed:18072184, ECO:0000269\|PubMed:19114591, ECO:0000269\|PubMed:21478274, ECO:0000269\|PubMed:23818633, ECO:0000269\|PubMed:25556658, ECO:0000269\|PubMed:26878239, ECO:0000269\|PubMed:27499292, ECO:0000269\|PubMed:7962047, ECO:0000269\|PubMed:9024683, ECO:0000305\|PubMed:20739937}.
P49790	NUP153	S226	ochoa	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269\|PubMed:12802065, ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269\|PubMed:23523133, ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:31913756}.
P49790	NUP153	S257	ochoa\|psp	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269\|PubMed:12802065, ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269\|PubMed:23523133, ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:31913756}.
P49792	RANBP2	S2297	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49815	TSC2	S1466	ochoa	Tuberin (Tuberous sclerosis 2 protein)	Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250\|UniProtKB:P49816, ECO:0000269\|PubMed:12172553, ECO:0000269\|PubMed:12271141, ECO:0000269\|PubMed:12820960, ECO:0000269\|PubMed:12842888, ECO:0000269\|PubMed:12906785, ECO:0000269\|PubMed:15340059, ECO:0000269\|PubMed:22819219, ECO:0000269\|PubMed:24529379, ECO:0000269\|PubMed:28215400, ECO:0000269\|PubMed:33436626, ECO:0000269\|PubMed:35772404}.
P49815	TSC2	S1469	ochoa	Tuberin (Tuberous sclerosis 2 protein)	Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250\|UniProtKB:P49816, ECO:0000269\|PubMed:12172553, ECO:0000269\|PubMed:12271141, ECO:0000269\|PubMed:12820960, ECO:0000269\|PubMed:12842888, ECO:0000269\|PubMed:12906785, ECO:0000269\|PubMed:15340059, ECO:0000269\|PubMed:22819219, ECO:0000269\|PubMed:24529379, ECO:0000269\|PubMed:28215400, ECO:0000269\|PubMed:33436626, ECO:0000269\|PubMed:35772404}.
P49916	LIG3	S227	ochoa	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269\|PubMed:10207110, ECO:0000269\|PubMed:24674627}.
P50851	LRBA	S1135	ochoa	Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)	Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250\|UniProtKB:Q9ESE1, ECO:0000269\|PubMed:33773106}.
P52701	MSH6	S309	ochoa\|psp	DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)	Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269\|PubMed:10078208, ECO:0000269\|PubMed:10660545, ECO:0000269\|PubMed:15064730, ECO:0000269\|PubMed:21120944, ECO:0000269\|PubMed:23622243, ECO:0000269\|PubMed:9564049, ECO:0000269\|PubMed:9822679, ECO:0000269\|PubMed:9822680}.
P55196	AFDN	S1199	ochoa	Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)	Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250\|UniProtKB:O35889, ECO:0000250\|UniProtKB:Q9QZQ1, ECO:0000269\|PubMed:11024295, ECO:0000269\|PubMed:30463011}.
P55197	MLLT10	S536	ochoa	Protein AF-10 (ALL1-fused gene from chromosome 10 protein)	Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269\|PubMed:17868029, ECO:0000269\|PubMed:26439302}.
P78310	CXADR	S323	ochoa	Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)	Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269\|PubMed:11734628, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:15800062, ECO:0000269\|PubMed:19064666, ECO:0000269\|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269\|PubMed:10567268, ECO:0000269\|PubMed:10666333, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269\|PubMed:10814575, ECO:0000269\|PubMed:14978041}.
P78312	FAM193A	S287	ochoa	Protein FAM193A (Protein IT14)	None
P78332	RBM6	S379	ochoa	RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)	Specifically binds poly(G) RNA homopolymers in vitro.
Q00536	CDK16	S155	ochoa\|psp	Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)	Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269\|PubMed:22184064, ECO:0000269\|PubMed:22796189, ECO:0000269\|PubMed:22798068}.
Q00537	CDK17	S182	ochoa	Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2)	May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}.
Q01484	ANK2	S3840	ochoa	Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)	Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250\|UniProtKB:Q8C8R3, ECO:0000269\|PubMed:12571597}.
Q02156	PRKCE	S346	ochoa\|psp	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269\|PubMed:11884385, ECO:0000269\|PubMed:1374067, ECO:0000269\|PubMed:15355962, ECO:0000269\|PubMed:16757566, ECO:0000269\|PubMed:17603037, ECO:0000269\|PubMed:17875639, ECO:0000269\|PubMed:17875724, ECO:0000269\|PubMed:19542546, ECO:0000269\|PubMed:21806543, ECO:0000269\|PubMed:36040231}.
Q02880	TOP2B	S1441	ochoa	DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)	Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269\|PubMed:10684600, ECO:0000269\|PubMed:31409799, ECO:0000269\|PubMed:32128574}.
Q03164	KMT2A	S3053	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q04656	ATP7A	S1447	ochoa	Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein)	ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250\|UniProtKB:Q64430, ECO:0000269\|PubMed:10419525, ECO:0000269\|PubMed:11092760, ECO:0000269\|PubMed:19453293, ECO:0000269\|PubMed:19917612, ECO:0000269\|PubMed:28389643, ECO:0000269\|PubMed:31283225}.
Q05209	PTPN12	S588	ochoa	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)	Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269\|PubMed:17329398, ECO:0000269\|PubMed:18559503, ECO:0000269\|PubMed:27134172}.
Q05397	PTK2	S910	ochoa\|psp	Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)	Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269\|PubMed:10655584, ECO:0000269\|PubMed:11331870, ECO:0000269\|PubMed:11980671, ECO:0000269\|PubMed:15166238, ECO:0000269\|PubMed:15561106, ECO:0000269\|PubMed:15895076, ECO:0000269\|PubMed:16919435, ECO:0000269\|PubMed:16927379, ECO:0000269\|PubMed:17395594, ECO:0000269\|PubMed:17431114, ECO:0000269\|PubMed:17968709, ECO:0000269\|PubMed:18006843, ECO:0000269\|PubMed:18206965, ECO:0000269\|PubMed:18256281, ECO:0000269\|PubMed:18292575, ECO:0000269\|PubMed:18497331, ECO:0000269\|PubMed:18677107, ECO:0000269\|PubMed:19138410, ECO:0000269\|PubMed:19147981, ECO:0000269\|PubMed:19224453, ECO:0000269\|PubMed:20332118, ECO:0000269\|PubMed:20495381, ECO:0000269\|PubMed:21454698, ECO:0000269\|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269\|PubMed:20109444}.
Q08050	FOXM1	S710	ochoa	Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)	Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269\|PubMed:17101782, ECO:0000269\|PubMed:19160488, ECO:0000269\|PubMed:20360045, ECO:0000269\|PubMed:33754036}.
Q08AD1	CAMSAP2	S980	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q08AD1	CAMSAP2	S1336	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q12834	CDC20	S153	psp	Cell division cycle protein 20 homolog (p55CDC)	Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250\|UniProtKB:Q9JJ66, ECO:0000269\|PubMed:27030811, ECO:0000269\|PubMed:29343641, ECO:0000269\|PubMed:32666501, ECO:0000269\|PubMed:9637688, ECO:0000269\|PubMed:9734353, ECO:0000269\|PubMed:9811605}.
Q13029	PRDM2	S464	ochoa	PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ)	S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269\|PubMed:14633678}.
Q13303	KCNAB2	S26	ochoa	Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)	Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250\|UniProtKB:P62482, ECO:0000250\|UniProtKB:P62483, ECO:0000269\|PubMed:11825900, ECO:0000269\|PubMed:7649300}.
Q13425	SNTB2	S239	ochoa	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)	Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Q13480	GAB1	S372	ochoa	GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269\|PubMed:29408807}.
Q13485	SMAD4	S155	ochoa	Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)	In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250, ECO:0000269\|PubMed:17327236, ECO:0000269\|PubMed:25514493, ECO:0000269\|PubMed:9389648}.
Q13501	SQSTM1	S224	ochoa	Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)	Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250\|UniProtKB:Q64337, ECO:0000269\|PubMed:10356400, ECO:0000269\|PubMed:10747026, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:12471037, ECO:0000269\|PubMed:15340068, ECO:0000269\|PubMed:15802564, ECO:0000269\|PubMed:15911346, ECO:0000269\|PubMed:15953362, ECO:0000269\|PubMed:16079148, ECO:0000269\|PubMed:16286508, ECO:0000269\|PubMed:17580304, ECO:0000269\|PubMed:19931284, ECO:0000269\|PubMed:20168092, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:22017874, ECO:0000269\|PubMed:22622177, ECO:0000269\|PubMed:24128730, ECO:0000269\|PubMed:25101860, ECO:0000269\|PubMed:26344566, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:28380357, ECO:0000269\|PubMed:28404643, ECO:0000269\|PubMed:29343546, ECO:0000269\|PubMed:29496741, ECO:0000269\|PubMed:29507397, ECO:0000269\|PubMed:31857589, ECO:0000269\|PubMed:33393215, ECO:0000269\|PubMed:33472082, ECO:0000269\|PubMed:33509017, ECO:0000269\|PubMed:34471133, ECO:0000269\|PubMed:34893540, ECO:0000269\|PubMed:35831301, ECO:0000269\|PubMed:37306101, ECO:0000269\|PubMed:37802024}.
Q14432	PDE3A	S492	ochoa\|psp	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)	Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269\|PubMed:1315035, ECO:0000269\|PubMed:25961942, ECO:0000269\|PubMed:27975297, ECO:0000269\|PubMed:31420216, ECO:0000269\|PubMed:34707099, ECO:0000269\|PubMed:8155697, ECO:0000269\|PubMed:8695850}.
Q14669	TRIP12	S102	ochoa	E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269\|PubMed:18627766, ECO:0000269\|PubMed:19028681, ECO:0000269\|PubMed:20208519, ECO:0000269\|PubMed:20829358, ECO:0000269\|PubMed:22884692, ECO:0000269\|PubMed:30982744}.
Q14676	MDC1	S981	ochoa	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)	Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269\|PubMed:12475977, ECO:0000269\|PubMed:12499369, ECO:0000269\|PubMed:12551934, ECO:0000269\|PubMed:12607003, ECO:0000269\|PubMed:12607004, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:12611903, ECO:0000269\|PubMed:14695167, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:15377652, ECO:0000269\|PubMed:16049003, ECO:0000269\|PubMed:16377563, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:30898438}.
Q14687	GSE1	S857	ochoa	Genetic suppressor element 1	None
Q15004	PCLAF	S89	ochoa	PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)	PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269\|PubMed:21673012, ECO:0000269\|PubMed:23000965}.
Q15007	WTAP	S358	ochoa	Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). {ECO:0000269\|PubMed:12444081, ECO:0000269\|PubMed:17088532, ECO:0000269\|PubMed:17095724, ECO:0000269\|PubMed:24316715, ECO:0000269\|PubMed:24407421, ECO:0000269\|PubMed:24981863, ECO:0000269\|PubMed:29507755}.
Q15020	SART3	S795	ochoa	Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)	U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250\|UniProtKB:Q9JLI8, ECO:0000269\|PubMed:12032085, ECO:0000269\|PubMed:14749385, ECO:0000269\|PubMed:20595234, ECO:0000269\|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269\|PubMed:11959860}.
Q15365	PCBP1	S190	ochoa	Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250\|UniProtKB:P60335, ECO:0000269\|PubMed:15731341, ECO:0000269\|PubMed:7556077, ECO:0000269\|PubMed:7607214, ECO:0000269\|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269\|PubMed:12414943}.
Q15596	NCOA2	S716	ochoa	Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)	Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250\|UniProtKB:Q61026, ECO:0000269\|PubMed:22504882, ECO:0000269\|PubMed:23508108, ECO:0000269\|PubMed:26553876, ECO:0000269\|PubMed:8670870, ECO:0000269\|PubMed:9430642}.
Q15746	MYLK	S1793	ochoa	Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269\|PubMed:11113114, ECO:0000269\|PubMed:11976941, ECO:0000269\|PubMed:15020676, ECO:0000269\|PubMed:15825080, ECO:0000269\|PubMed:16284075, ECO:0000269\|PubMed:16723733, ECO:0000269\|PubMed:18587400, ECO:0000269\|PubMed:18710790, ECO:0000269\|PubMed:19826488, ECO:0000269\|PubMed:20139351, ECO:0000269\|PubMed:20181817, ECO:0000269\|PubMed:20375339, ECO:0000269\|PubMed:20453870}.
Q16625	OCLN	S327	ochoa	Occludin	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269\|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269\|PubMed:19182773, ECO:0000269\|PubMed:20375010}.
Q2KHR3	QSER1	S1228	ochoa	Glutamine and serine-rich protein 1	Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269\|PubMed:33833093}.
Q2LD37	BLTP1	S2754	ochoa	Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein)	Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269\|PubMed:30906834, ECO:0000269\|PubMed:31540829, ECO:0000305\|PubMed:35015055, ECO:0000305\|PubMed:35491307}.
Q2M1Z3	ARHGAP31	S1071	ochoa	Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)	Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269\|PubMed:12192056, ECO:0000269\|PubMed:16519628}.
Q3MII6	TBC1D25	S157	ochoa	TBC1 domain family member 25	Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269\|PubMed:21383079}.
Q3V6T2	CCDC88A	S1583	ochoa	Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)	Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250\|UniProtKB:Q5SNZ0, ECO:0000269\|PubMed:15882442, ECO:0000269\|PubMed:16139227, ECO:0000269\|PubMed:19211784, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:21954290, ECO:0000269\|PubMed:23509302, ECO:0000269\|PubMed:25187647, ECO:0000269\|PubMed:27621449, ECO:0000269\|PubMed:27623382}.
Q4ADV7	RIC1	S1149	ochoa	Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1)	The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269\|PubMed:16112082, ECO:0000269\|PubMed:23091056, ECO:0000269\|PubMed:31932796}.
Q4KMP7	TBC1D10B	S158	ochoa	TBC1 domain family member 10B (Rab27A-GAP-beta)	Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269\|PubMed:16923811, ECO:0000269\|PubMed:19077034}.
Q4L180	FILIP1L	S1052	ochoa	Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)	Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269\|PubMed:18794120}.
Q52LD8	RFTN2	S470	ochoa	Raftlin-2 (Raft-linking protein 2)	Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250\|UniProtKB:Q8CHX7}.
Q5PRF9	SAMD4B	S609	ochoa	Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B)	Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269\|PubMed:20510020}.
Q5SW79	CEP170	S862	ochoa	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q5SY16	NOL9	S105	ochoa	Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9)	Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269\|PubMed:21063389, ECO:0000269\|PubMed:31288032}.
Q5T1M5	FKBP15	S1131	ochoa	FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)	May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269\|PubMed:19121306}.
Q5T200	ZC3H13	S335	ochoa	Zinc finger CCCH domain-containing protein 13	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250\|UniProtKB:E9Q784}.
Q5T200	ZC3H13	S848	ochoa	Zinc finger CCCH domain-containing protein 13	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250\|UniProtKB:E9Q784}.
Q5T5P2	KIAA1217	S1896	ochoa	Sickle tail protein homolog	Required for normal development of intervertebral disks. {ECO:0000250\|UniProtKB:A2AQ25}.
Q5T5X7	BEND3	S181	ochoa	BEN domain-containing protein 3	Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250\|UniProtKB:Q6PAL0, ECO:0000269\|PubMed:21914818, ECO:0000269\|PubMed:26100909, ECO:0000269\|PubMed:28977671}.
Q5UIP0	RIF1	S2189	ochoa	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250\|UniProtKB:Q6PR54, ECO:0000269\|PubMed:15342490, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:28241136}.
Q5VST9	OBSCN	S6868	ochoa	Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK)	Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250\|UniProtKB:A2AAJ9, ECO:0000269\|PubMed:11448995, ECO:0000269\|PubMed:16205939, ECO:0000269\|PubMed:28826662}.
Q5VV41	ARHGEF16	S208	ochoa	Rho guanine nucleotide exchange factor 16 (Ephexin-4)	Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269\|PubMed:20679435}.
Q5VWQ8	DAB2IP	S974	ochoa	Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein)	Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269\|PubMed:12813029, ECO:0000269\|PubMed:17389591, ECO:0000269\|PubMed:18292600, ECO:0000269\|PubMed:19033661, ECO:0000269\|PubMed:19903888, ECO:0000269\|PubMed:19948740, ECO:0000269\|PubMed:20080667, ECO:0000269\|PubMed:20154697, ECO:0000269\|PubMed:21700930, ECO:0000269\|PubMed:22696229, ECO:0000269\|PubMed:29156729}.
Q5W0B1	OBI1	S570	ochoa	ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219)	E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269\|PubMed:31160578}.
Q69YQ0	SPECC1L	S887	ochoa	Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)	Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269\|PubMed:21703590}.
Q6IAA8	LAMTOR1	S45	ochoa	Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)	Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250\|UniProtKB:Q9CQ22, ECO:0000269\|PubMed:19654316, ECO:0000269\|PubMed:20381137, ECO:0000269\|PubMed:20544018, ECO:0000269\|PubMed:22980980, ECO:0000269\|PubMed:28935770, ECO:0000269\|PubMed:29107538, ECO:0000269\|PubMed:29123114, ECO:0000269\|PubMed:29158492, ECO:0000269\|PubMed:29285400, ECO:0000269\|PubMed:30181260, ECO:0000269\|PubMed:31001086, ECO:0000269\|PubMed:32686708, ECO:0000269\|PubMed:36476874}.
Q6IQ49	SDE2	S170	ochoa	Splicing regulator SDE2 (Replication stress response regulator SDE2)	Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959). {ECO:0000269\|PubMed:27906959}.; FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (PubMed:34365507). May recruit CACTIN to the spliceosome (By similarity). {ECO:0000250\|UniProtKB:O14113, ECO:0000269\|PubMed:34365507}.; FUNCTION: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (PubMed:34365507). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (PubMed:34365507). {ECO:0000269\|PubMed:34365507}.
Q6KC79	NIPBL	S153	ochoa	Nipped-B-like protein (Delangin) (SCC2 homolog)	Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250\|UniProtKB:Q6KCD5, ECO:0000269\|PubMed:22628566, ECO:0000269\|PubMed:28167679, ECO:0000269\|PubMed:28914604}.
Q6KC79	NIPBL	S367	ochoa	Nipped-B-like protein (Delangin) (SCC2 homolog)	Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250\|UniProtKB:Q6KCD5, ECO:0000269\|PubMed:22628566, ECO:0000269\|PubMed:28167679, ECO:0000269\|PubMed:28914604}.
Q6N021	TET2	S38	ochoa	Methylcytosine dioxygenase TET2 (EC 1.14.11.80)	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269\|PubMed:19483684, ECO:0000269\|PubMed:21057493, ECO:0000269\|PubMed:21817016, ECO:0000269\|PubMed:23222540, ECO:0000269\|PubMed:23353889, ECO:0000269\|PubMed:24315485, ECO:0000269\|PubMed:32518946}.
Q6P0Q8	MAST2	S200	ochoa	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6P4F7	ARHGAP11A	S335	ochoa	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269\|PubMed:27957544}.
Q6P996	PDXDC1	S669	ochoa	Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)	None
Q6PJP8	DCLRE1A	S255	ochoa	DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A)	May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269\|PubMed:15542852}.
Q6PKG0	LARP1	S868	ochoa	La-related protein 1 (La ribonucleoprotein domain family member 1)	RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269\|PubMed:20430826, ECO:0000269\|PubMed:23711370, ECO:0000269\|PubMed:24532714, ECO:0000269\|PubMed:25940091, ECO:0000269\|PubMed:26206669, ECO:0000269\|PubMed:28379136, ECO:0000269\|PubMed:28650797, ECO:0000269\|PubMed:28673543, ECO:0000269\|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269\|PubMed:26735137}.
Q6R327	RICTOR	S1370	ochoa	Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)	Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250\|UniProtKB:Q6QI06, ECO:0000269\|PubMed:15268862, ECO:0000269\|PubMed:15467718, ECO:0000269\|PubMed:15718470, ECO:0000269\|PubMed:19720745, ECO:0000269\|PubMed:19935711, ECO:0000269\|PubMed:19995915, ECO:0000269\|PubMed:21343617, ECO:0000269\|PubMed:33158864, ECO:0000269\|PubMed:35904232, ECO:0000269\|PubMed:35926713}.
Q6T4R5	NHS	Y1193	ochoa	Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein)	May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269\|PubMed:20332100}.
Q6UUV7	CRTC3	S413	ochoa	CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:14506290, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:15466468, ECO:0000269\|PubMed:16817901, ECO:0000269\|PubMed:16980408, ECO:0000269\|PubMed:17210223, ECO:0000269\|PubMed:17644518}.
Q6XZF7	DNMBP	S1388	ochoa	Dynamin-binding protein (Scaffold protein Tuba)	Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250\|UniProtKB:E2RP94, ECO:0000250\|UniProtKB:Q6TXD4, ECO:0000269\|PubMed:17015620, ECO:0000269\|PubMed:19767742, ECO:0000269\|PubMed:20479467}.
Q6ZMT1	STAC2	S192	ochoa	SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2)	Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250\|UniProtKB:Q8R1B0}.
Q6ZNL6	FGD5	S720	ochoa	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)	Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269\|PubMed:22328776}.
Q6ZRV2	FAM83H	S867	ochoa	Protein FAM83H	May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269\|PubMed:18252228, ECO:0000269\|PubMed:23902688}.
Q7Z3J3	RGPD4	S1322	ochoa	RanBP2-like and GRIP domain-containing protein 4	None
Q7Z422	SZRD1	S124	ochoa	SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22)	None
Q7Z434	MAVS	S275	ochoa	Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)	Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269\|PubMed:16125763, ECO:0000269\|PubMed:16127453, ECO:0000269\|PubMed:16153868, ECO:0000269\|PubMed:16177806, ECO:0000269\|PubMed:19631370, ECO:0000269\|PubMed:20127681, ECO:0000269\|PubMed:20451243, ECO:0000269\|PubMed:20628368, ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:23087404, ECO:0000269\|PubMed:23582325, ECO:0000269\|PubMed:25636800, ECO:0000269\|PubMed:27736772, ECO:0000269\|PubMed:27992402, ECO:0000269\|PubMed:33110251, ECO:0000269\|PubMed:33139700, ECO:0000269\|PubMed:37582970}.
Q7Z460	CLASP1	S705	ochoa	CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1)	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269\|PubMed:11290329, ECO:0000269\|PubMed:12837247, ECO:0000269\|PubMed:15631994, ECO:0000269\|PubMed:16866869, ECO:0000269\|PubMed:16914514, ECO:0000269\|PubMed:17543864}.
Q7Z4H7	HAUS6	S524	ochoa	HAUS augmin-like complex subunit 6	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19369198, ECO:0000269\|PubMed:19427217}.
Q7Z4H7	HAUS6	S569	ochoa	HAUS augmin-like complex subunit 6	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19369198, ECO:0000269\|PubMed:19427217}.
Q7Z4V5	HDGFL2	S200	ochoa	Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)	Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269\|PubMed:25689719, ECO:0000269\|PubMed:26721387, ECO:0000269\|PubMed:32459350}.
Q86SQ0	PHLDB2	S56	ochoa	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12376540}.
Q86SQ0	PHLDB2	S351	ochoa	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12376540}.
Q86U44	METTL3	S67	ochoa\|psp	N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70)	The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250\|UniProtKB:Q8C3P7, ECO:0000269\|PubMed:22575960, ECO:0000269\|PubMed:24284625, ECO:0000269\|PubMed:25719671, ECO:0000269\|PubMed:25799998, ECO:0000269\|PubMed:26321680, ECO:0000269\|PubMed:26593424, ECO:0000269\|PubMed:27117702, ECO:0000269\|PubMed:27281194, ECO:0000269\|PubMed:27373337, ECO:0000269\|PubMed:27602518, ECO:0000269\|PubMed:27627798, ECO:0000269\|PubMed:28297716, ECO:0000269\|PubMed:28637692, ECO:0000269\|PubMed:29348140, ECO:0000269\|PubMed:29506078, ECO:0000269\|PubMed:30428350, ECO:0000269\|PubMed:30559377, ECO:0000269\|PubMed:33961823, ECO:0000269\|PubMed:9409616}.
Q86UU1	PHLDB1	S535	ochoa	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha)	None
Q86V48	LUZP1	S440	ochoa	Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin)	F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250\|UniProtKB:Q8R4U7, ECO:0000269\|PubMed:30990684, ECO:0000269\|PubMed:32496561, ECO:0000269\|PubMed:38009294, ECO:0000269\|PubMed:38832964}.
Q86V48	LUZP1	S822	ochoa	Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin)	F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250\|UniProtKB:Q8R4U7, ECO:0000269\|PubMed:30990684, ECO:0000269\|PubMed:32496561, ECO:0000269\|PubMed:38009294, ECO:0000269\|PubMed:38832964}.
Q86YV5	PRAG1	S844	ochoa	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250\|UniProtKB:D3ZMK9, ECO:0000250\|UniProtKB:Q571I4}.
Q8IVL1	NAV2	S1319	ochoa	Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)	Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269\|PubMed:12214280, ECO:0000269\|PubMed:15158073}.
Q8IWV8	UBR2	S1023	ochoa	E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242, PubMed:28392261). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:20835242, PubMed:28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:20835242, PubMed:28392261). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:20835242). In contrast, it strongly binds methylated N-degrons (PubMed:28392261). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). Plays a role in T-cell receptor signaling by inducing 'Lys-63'-linked ubiquitination of lymphocyte cell-specific kinase LCK (PubMed:38225265). This activity is regulated by DUSP22, which induces 'Lys-48'-linked ubiquitination of UBR2, leading to its proteasomal degradation by SCF E3 ubiquitin-protein ligase complex (PubMed:38225265). {ECO:0000250\|UniProtKB:Q6WKZ8, ECO:0000269\|PubMed:15548684, ECO:0000269\|PubMed:20298436, ECO:0000269\|PubMed:20835242, ECO:0000269\|PubMed:28392261, ECO:0000269\|PubMed:38225265}.
Q8IYB3	SRRM1	S431	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8IZD2	KMT2E	S854	ochoa	Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5)	Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250\|UniProtKB:Q3UG20, ECO:0000269\|PubMed:14718661, ECO:0000269\|PubMed:18573682, ECO:0000269\|PubMed:23629655, ECO:0000269\|PubMed:23798402, ECO:0000269\|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269\|PubMed:23958951}.
Q8N3V7	SYNPO	S702	ochoa	Synaptopodin	Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N4S9	MARVELD2	S145	ochoa	MARVEL domain-containing protein 2 (Tricellulin)	Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250\|UniProtKB:Q3UZP0, ECO:0000269\|PubMed:17186462}.
Q8N556	AFAP1	S682	ochoa	Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)	Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269\|PubMed:15485829}.
Q8N8Z6	DCBLD1	S657	ochoa\|psp	Discoidin, CUB and LCCL domain-containing protein 1	None
Q8NEN9	PDZD8	S538	ochoa	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104)	Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269\|PubMed:21549406, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:29097544}.
Q8NEY1	NAV1	S1270	ochoa	Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)	May be involved in neuronal migration. {ECO:0000250}.
Q8NEY8	PPHLN1	S172	ochoa	Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50)	Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269\|PubMed:15474462, ECO:0000269\|PubMed:17963697, ECO:0000269\|PubMed:26022416, ECO:0000269\|PubMed:30487602, ECO:0000305\|PubMed:12853457}.
Q8NHG8	ZNRF2	S116	ochoa	E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)	E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269\|PubMed:14561866, ECO:0000269\|PubMed:22797923, ECO:0000269\|PubMed:27244671}.
Q8TAQ2	SMARCC2	S321	ochoa	SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250\|UniProtKB:Q6PDG5, ECO:0000269\|PubMed:10078207, ECO:0000269\|PubMed:11018012, ECO:0000269\|PubMed:12192000, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
Q8TB45	DEPTOR	S316	ochoa	DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)	Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269\|PubMed:19446321, ECO:0000269\|PubMed:22017875, ECO:0000269\|PubMed:22017876, ECO:0000269\|PubMed:22017877, ECO:0000269\|PubMed:25936805, ECO:0000269\|PubMed:29382726, ECO:0000269\|PubMed:34519268, ECO:0000269\|PubMed:34519269}.
Q8TBN0	RAB3IL1	S196	ochoa	Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)	Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269\|PubMed:20937701}.
Q8TC05	MDM1	S601	ochoa	Nuclear protein MDM1	Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269\|PubMed:26337392}.
Q8TC26	TMEM163	S55	ochoa	Transmembrane protein 163	Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250\|UniProtKB:A9CMA6, ECO:0000269\|PubMed:25130899, ECO:0000269\|PubMed:31697912, ECO:0000269\|PubMed:32492420, ECO:0000269\|PubMed:35455965, ECO:0000269\|PubMed:36204728}.
Q8TER5	ARHGEF40	S1491	ochoa	Rho guanine nucleotide exchange factor 40 (Protein SOLO)	May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Q8TEW8	PARD3B	S990	ochoa	Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein)	Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WUJ0	STYX	S201	ochoa	Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)	Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). {ECO:0000250\|UniProtKB:Q60969, ECO:0000269\|PubMed:23847209, ECO:0000269\|PubMed:28007894}.
Q8WVV4	POF1B	S93	ochoa	Protein POF1B (Premature ovarian failure protein 1B)	Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269\|PubMed:16773570, ECO:0000269\|PubMed:21940798}.
Q8WWQ0	PHIP	S1474	ochoa	PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)	Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269\|PubMed:12242307, ECO:0000269\|PubMed:21834987}.
Q8WX93	PALLD	S1121	ochoa	Palladin (SIH002) (Sarcoma antigen NY-SAR-77)	Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269\|PubMed:11598191, ECO:0000269\|PubMed:15147863, ECO:0000269\|PubMed:17537434}.
Q8WYL5	SSH1	S988	ochoa	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)	Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269\|PubMed:11832213, ECO:0000269\|PubMed:12684437, ECO:0000269\|PubMed:12807904, ECO:0000269\|PubMed:14531860, ECO:0000269\|PubMed:14645219, ECO:0000269\|PubMed:15056216, ECO:0000269\|PubMed:15159416, ECO:0000269\|PubMed:15660133, ECO:0000269\|PubMed:15671020, ECO:0000269\|PubMed:16230460}.
Q92551	IP6K1	S146	ochoa	Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1)	Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Q92585	MAML1	S331	ochoa	Mastermind-like protein 1 (Mam-1)	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269\|PubMed:11101851, ECO:0000269\|PubMed:11390662, ECO:0000269\|PubMed:12050117, ECO:0000269\|PubMed:15546612, ECO:0000269\|PubMed:17317671}.
Q92615	LARP4B	S451	ochoa	La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5)	Stimulates mRNA translation. {ECO:0000269\|PubMed:20573744}.
Q92738	USP6NL	S676	ochoa	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)	Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269\|PubMed:11099046, ECO:0000269\|PubMed:17562788, ECO:0000269\|PubMed:17684057}.
Q96CP6	GRAMD1A	S284	ochoa	Protein Aster-A (GRAM domain-containing protein 1A)	Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250\|UniProtKB:Q8VEF1, ECO:0000269\|PubMed:31222192}.
Q96D71	REPS1	S499	ochoa	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)	May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96F86	EDC3	S148	ochoa	Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)	Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269\|PubMed:16364915, ECO:0000269\|PubMed:17533573, ECO:0000269\|PubMed:18678652, ECO:0000269\|PubMed:25701870}.
Q96HC4	PDLIM5	S377	ochoa	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)	May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250\|UniProtKB:Q62920}.
Q96HH9	GRAMD2B	S242	ochoa	GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2)	None
Q96JM3	CHAMP1	S462	ochoa	Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)	Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269\|PubMed:21063390}.
Q96KB5	PBK	S76	ochoa	Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)	Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269\|PubMed:10781613, ECO:0000269\|PubMed:17482142}.
Q96L73	NSD1	S965	ochoa	Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)	Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269\|PubMed:21196496}.
Q96N67	DOCK7	S917	ochoa	Dedicator of cytokinesis protein 7	Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250\|UniProtKB:Q8R1A4, ECO:0000269\|PubMed:16982419, ECO:0000269\|PubMed:29467281}.
Q96N67	DOCK7	S963	ochoa	Dedicator of cytokinesis protein 7	Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250\|UniProtKB:Q8R1A4, ECO:0000269\|PubMed:16982419, ECO:0000269\|PubMed:29467281}.
Q96NY7	CLIC6	S322	ochoa	Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin)	In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250\|UniProtKB:Q9N2G5, ECO:0000250\|UniProtKB:Q9Y696, ECO:0000269\|PubMed:37838179}.
Q96QS3	ARX	S37	psp	Homeobox protein ARX (Aristaless-related homeobox)	Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250\|UniProtKB:O35085, ECO:0000269\|PubMed:11889467, ECO:0000269\|PubMed:12379852, ECO:0000269\|PubMed:14722918, ECO:0000269\|PubMed:22194193, ECO:0000269\|PubMed:31691806}.
Q96RS0	TGS1	S315	ochoa	Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269\|PubMed:11517327, ECO:0000269\|PubMed:11912212, ECO:0000269\|PubMed:16687569, ECO:0000269\|PubMed:18775984}.
Q96T58	SPEN	S1278	ochoa	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250\|UniProtKB:Q62504, ECO:0000269\|PubMed:11331609, ECO:0000269\|PubMed:12374742}.
Q99536	VAT1	S35	ochoa	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-)	Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269\|PubMed:12898150, ECO:0000269\|PubMed:17105775, ECO:0000269\|PubMed:19508442}.
Q99640	PKMYT1	S160	ochoa	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)	Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269\|PubMed:10373560, ECO:0000269\|PubMed:10504341, ECO:0000269\|PubMed:9001210, ECO:0000269\|PubMed:9268380}.
Q99700	ATXN2	S530	ochoa	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269\|PubMed:18602463}.
Q99755	PIP5K1A	S475	ochoa	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)	Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250\|UniProtKB:P70182, ECO:0000269\|PubMed:18288197, ECO:0000269\|PubMed:19158393, ECO:0000269\|PubMed:20660631, ECO:0000269\|PubMed:21477596, ECO:0000269\|PubMed:22942276, ECO:0000269\|PubMed:8955136}.
Q99959	PKP2	S172	ochoa	Plakophilin-2	A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250\|UniProtKB:F1M7L9, ECO:0000250\|UniProtKB:Q9CQ73, ECO:0000269\|PubMed:18662195, ECO:0000269\|PubMed:20613778, ECO:0000269\|PubMed:22781308, ECO:0000269\|PubMed:23884246, ECO:0000269\|PubMed:25208567, ECO:0000269\|PubMed:28169297, ECO:0000269\|PubMed:34368962, ECO:0000269\|PubMed:35959657}.
Q9C0C2	TNKS1BP1	S195	ochoa	182 kDa tankyrase-1-binding protein	None
Q9C0H5	ARHGAP39	S190	ochoa	Rho GTPase-activating protein 39	None
Q9C0H5	ARHGAP39	S303	ochoa	Rho GTPase-activating protein 39	None
Q9GZR2	REXO4	S128	ochoa	RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2)	None
Q9H1E3	NUCKS1	S198	ochoa	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)	Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269\|PubMed:26323318}.
Q9H2G9	BLZF1	S32	ochoa	Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor)	Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269\|PubMed:11739401}.
Q9H2P0	ADNP	S426	ochoa	Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein)	May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250\|UniProtKB:Q9Z103}.
Q9H2Y7	ZNF106	S658	ochoa	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474)	RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250\|UniProtKB:O88466}.
Q9H3D4	TP63	S68	psp	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269\|PubMed:11641404, ECO:0000269\|PubMed:12374749, ECO:0000269\|PubMed:12446779, ECO:0000269\|PubMed:12446784, ECO:0000269\|PubMed:20123734, ECO:0000269\|PubMed:22197488, ECO:0000269\|PubMed:9774969}.
Q9H694	BICC1	S43	ochoa	Protein bicaudal C homolog 1 (Bic-C)	Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269\|PubMed:21922595}.
Q9H6S3	EPS8L2	S466	ochoa	Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250\|UniProtKB:Q99K30, ECO:0000269\|PubMed:14565974}.
Q9H706	GAREM1	S759	ochoa	GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)	[Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269\|PubMed:19509291}.
Q9HAS0	C17orf75	S76	ochoa	Protein Njmu-R1	As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269\|PubMed:29426865}.
Q9HB58	SP110	S192	ochoa	Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110)	Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Q9HC35	EML4	S163	ochoa	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)	Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269\|PubMed:16890222, ECO:0000269\|PubMed:25789526, ECO:0000269\|PubMed:31409757}.
Q9HCG8	CWC22	S108	ochoa	Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)	Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:12226669, ECO:0000269\|PubMed:22959432, ECO:0000269\|PubMed:22961380, ECO:0000269\|PubMed:23236153, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000305\|PubMed:33509932}.
Q9NP61	ARFGAP3	S348	ochoa	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3)	GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269\|PubMed:11172815}.
Q9NQS7	INCENP	S214	ochoa	Inner centromere protein	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250\|UniProtKB:P53352, ECO:0000269\|PubMed:12925766, ECO:0000269\|PubMed:15316025, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:21346195, ECO:0000269\|PubMed:27332895}.
Q9NR48	ASH1L	S576	ochoa	Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)	Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250\|UniProtKB:Q99MY8, ECO:0000269\|PubMed:21239497}.
Q9NRA8	EIF4ENIF1	T769	ochoa	Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)	EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250\|UniProtKB:Q9EST3, ECO:0000269\|PubMed:10856257, ECO:0000269\|PubMed:16157702, ECO:0000269\|PubMed:22966201, ECO:0000269\|PubMed:24335285, ECO:0000269\|PubMed:27342281, ECO:0000269\|PubMed:28216671, ECO:0000269\|PubMed:28487484, ECO:0000269\|PubMed:32354837}.
Q9NVW2	RLIM	S247	ochoa	E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)	E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269\|PubMed:19164295, ECO:0000269\|PubMed:19945382}.
Q9NW68	BSDC1	S109	ochoa	BSD domain-containing protein 1	None
Q9NYB9	ABI2	S233	ochoa	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)	Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250\|UniProtKB:P62484, ECO:0000269\|PubMed:10498863, ECO:0000269\|PubMed:15572692, ECO:0000269\|PubMed:21107423, ECO:0000269\|PubMed:7590236, ECO:0000269\|PubMed:8649853}.
Q9NYL2	MAP3K20	S654	ochoa	Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)	Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269\|PubMed:10924358, ECO:0000269\|PubMed:11042189, ECO:0000269\|PubMed:11836244, ECO:0000269\|PubMed:12220515, ECO:0000269\|PubMed:14521931, ECO:0000269\|PubMed:15172994, ECO:0000269\|PubMed:15342622, ECO:0000269\|PubMed:15350844, ECO:0000269\|PubMed:15737997, ECO:0000269\|PubMed:18331592, ECO:0000269\|PubMed:20559024, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:26999302, ECO:0000269\|PubMed:27859413, ECO:0000269\|PubMed:32289254, ECO:0000269\|PubMed:32610081, ECO:0000269\|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269\|PubMed:15684425, ECO:0000269\|PubMed:32289254, ECO:0000269\|PubMed:32610081, ECO:0000269\|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269\|PubMed:27859413, ECO:0000269\|PubMed:32289254, ECO:0000269\|PubMed:32610081, ECO:0000269\|PubMed:35857590}.
Q9NYV4	CDK12	S440	ochoa	Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269\|PubMed:11683387, ECO:0000269\|PubMed:19651820, ECO:0000269\|PubMed:20952539, ECO:0000269\|PubMed:22012619, ECO:0000269\|PubMed:24662513}.
Q9P107	GMIP	S454	ochoa	GEM-interacting protein (GMIP)	Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269\|PubMed:12093360}.
Q9P1Y5	CAMSAP3	S368	ochoa	Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250\|UniProtKB:Q80VC9, ECO:0000269\|PubMed:19041755, ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:26715742, ECO:0000269\|PubMed:27693509, ECO:0000269\|PubMed:27802168, ECO:0000269\|PubMed:28089391, ECO:0000269\|PubMed:28386021}.
Q9P1Y5	CAMSAP3	S1048	ochoa	Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250\|UniProtKB:Q80VC9, ECO:0000269\|PubMed:19041755, ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:26715742, ECO:0000269\|PubMed:27693509, ECO:0000269\|PubMed:27802168, ECO:0000269\|PubMed:28089391, ECO:0000269\|PubMed:28386021}.
Q9P227	ARHGAP23	S603	ochoa	Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9P246	STIM2	S626	ochoa	Stromal interaction molecule 2	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269\|PubMed:16005298, ECO:0000269\|PubMed:16860747, ECO:0000269\|PubMed:17905723, ECO:0000269\|PubMed:18160041, ECO:0000269\|PubMed:21217057, ECO:0000269\|PubMed:22464749, ECO:0000269\|PubMed:23359669}.
Q9P2Q2	FRMD4A	S711	ochoa	FERM domain-containing protein 4A	Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250\|UniProtKB:Q8BIE6, ECO:0000269\|PubMed:27044754}.
Q9UBC2	EPS15L1	S372	ochoa	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.
Q9UBF8	PI4KB	S275	ochoa	Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)	Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250\|UniProtKB:O08561, ECO:0000269\|PubMed:10559940, ECO:0000269\|PubMed:11277933, ECO:0000269\|PubMed:12749687, ECO:0000269\|PubMed:33358777, ECO:0000269\|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269\|PubMed:22124328, ECO:0000269\|PubMed:22258260, ECO:0000269\|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269\|PubMed:22253445}.
Q9UBW5	BIN2	S294	ochoa	Bridging integrator 2 (Breast cancer-associated protein 1)	Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269\|PubMed:23285027}.
Q9UDY2	TJP2	S432	ochoa	Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2)	Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250\|UniProtKB:Q9Z0U1}.
Q9UEY8	ADD3	S478	ochoa	Gamma-adducin (Adducin-like protein 70)	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250\|UniProtKB:Q62847, ECO:0000250\|UniProtKB:Q9QYB5, ECO:0000269\|PubMed:23836506, ECO:0000305}.
Q9UHB6	LIMA1	S507	ochoa	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)	Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250\|UniProtKB:Q9ERG0, ECO:0000269\|PubMed:12566430, ECO:0000269\|PubMed:32496561, ECO:0000269\|PubMed:33999101}.
Q9UHI6	DDX20	S549	ochoa	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3)	The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269\|PubMed:18984161}.
Q9UHR4	BAIAP2L1	S278	ochoa	BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)	May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269\|PubMed:17430976, ECO:0000269\|PubMed:19366662, ECO:0000269\|PubMed:22921828}.
Q9UK32	RPS6KA6	S389	ochoa\|psp	Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)	Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269\|PubMed:15042092, ECO:0000269\|PubMed:15632195}.
Q9UK58	CCNL1	S352	ochoa	Cyclin-L1 (Cyclin-L)	Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269\|PubMed:11980906, ECO:0000269\|PubMed:12414649, ECO:0000269\|PubMed:15700036, ECO:0000269\|PubMed:18216018}.
Q9UKL3	CASP8AP2	S875	ochoa	CASP8-associated protein 2 (FLICE-associated huge protein)	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269\|PubMed:12477726, ECO:0000269\|PubMed:15698540, ECO:0000269\|PubMed:17003125, ECO:0000269\|PubMed:17245429}.
Q9UKL3	CASP8AP2	S945	ochoa	CASP8-associated protein 2 (FLICE-associated huge protein)	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269\|PubMed:12477726, ECO:0000269\|PubMed:15698540, ECO:0000269\|PubMed:17003125, ECO:0000269\|PubMed:17245429}.
Q9ULH0	KIDINS220	S1488	ochoa	Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)	Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269\|PubMed:18089783}.
Q9ULH1	ASAP1	S743	ochoa	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)	Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269\|PubMed:20393563, ECO:0000269\|PubMed:25673879}.
Q9ULH1	ASAP1	S1044	ochoa	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)	Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269\|PubMed:20393563, ECO:0000269\|PubMed:25673879}.
Q9ULW0	TPX2	S310	ochoa\|psp	Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)	Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269\|PubMed:18663142, ECO:0000269\|PubMed:19208764, ECO:0000269\|PubMed:26165940}.
Q9UMD9	COL17A1	S135	ochoa	Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)]	May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Q9UMS6	SYNPO2	S243	ochoa	Synaptopodin-2 (Genethonin-2) (Myopodin)	Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250\|UniProtKB:D4A702, ECO:0000250\|UniProtKB:Q91YE8, ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:23225103, ECO:0000269\|PubMed:24005909, ECO:0000269\|PubMed:25883213, ECO:0000305\|PubMed:16885336, ECO:0000305\|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909, ECO:0000269\|PubMed:25883213}.
Q9UMZ2	SYNRG	S936	ochoa	Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)	Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269\|PubMed:15758025, ECO:0000305\|PubMed:12538641}.
Q9UNF1	MAGED2	S264	ochoa	Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen)	Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269\|PubMed:27120771}.
Q9UQ35	SRRM2	S931	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9Y2F5	ICE1	S533	ochoa	Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1)	Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269\|PubMed:22195968, ECO:0000269\|PubMed:23932780}.
Q9Y2H5	PLEKHA6	S794	ochoa	Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)	None
Q9Y2K6	USP20	S390	ochoa	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)	Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269\|PubMed:12056827, ECO:0000269\|PubMed:12865408, ECO:0000269\|PubMed:15776016, ECO:0000269\|PubMed:19424180, ECO:0000269\|PubMed:26839314, ECO:0000269\|PubMed:27801882, ECO:0000269\|PubMed:29487085, ECO:0000269\|PubMed:32354117, ECO:0000269\|PubMed:33792613, ECO:0000269\|PubMed:35063767}.
Q9Y2M0	FAN1	S197	ochoa	Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269\|PubMed:20603015, ECO:0000269\|PubMed:20603016, ECO:0000269\|PubMed:20603073, ECO:0000269\|PubMed:20671156, ECO:0000269\|PubMed:24981866, ECO:0000269\|PubMed:25135477, ECO:0000269\|PubMed:25430771}.
Q9Y2W1	THRAP3	T327	ochoa	Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269\|PubMed:20123736, ECO:0000269\|PubMed:20932480, ECO:0000269\|PubMed:22424773, ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:24043798}.
Q9Y2X7	GIT1	S588	ochoa	ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)	GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250\|UniProtKB:Q68FF6, ECO:0000250\|UniProtKB:Q9Z272, ECO:0000269\|PubMed:10938112, ECO:0000269\|PubMed:11896197, ECO:0000269\|PubMed:12695502, ECO:0000269\|PubMed:15800193, ECO:0000269\|PubMed:15923189, ECO:0000269\|PubMed:19273721, ECO:0000269\|PubMed:23108400, ECO:0000269\|PubMed:25284783, ECO:0000269\|PubMed:27012601, ECO:0000269\|PubMed:31502302}.
Q9Y4F1	FARP1	S889	ochoa	FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)	Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y4J8	DTNA	S581	ochoa	Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)	May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Q9Y4W2	LAS1L	S545	ochoa	Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog)	Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269\|PubMed:20647540, ECO:0000269\|PubMed:22083961, ECO:0000269\|PubMed:22872859}.
Q9Y6R1	SLC4A4	S262	ochoa	Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)	Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269\|PubMed:10069984, ECO:0000269\|PubMed:11744745, ECO:0000269\|PubMed:12411514, ECO:0000269\|PubMed:12730338, ECO:0000269\|PubMed:12907161, ECO:0000269\|PubMed:14567693, ECO:0000269\|PubMed:15218065, ECO:0000269\|PubMed:15713912, ECO:0000269\|PubMed:15817634, ECO:0000269\|PubMed:15930088, ECO:0000269\|PubMed:16636648, ECO:0000269\|PubMed:16769890, ECO:0000269\|PubMed:17661077, ECO:0000269\|PubMed:23324180, ECO:0000269\|PubMed:23636456, ECO:0000269\|PubMed:29500354, ECO:0000269\|PubMed:9235899, ECO:0000269\|PubMed:9651366}.
O75208	COQ9	S95	Sugiyama	Ubiquinone biosynthesis protein COQ9, mitochondrial	Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step (PubMed:25339443, PubMed:30661980, PubMed:38425362). Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25339443, PubMed:30661980). {ECO:0000269\|PubMed:25339443, ECO:0000269\|PubMed:30661980, ECO:0000269\|PubMed:38425362}.
Q92917	GPKOW	S59	Sugiyama	G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54)	RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:25296192, ECO:0000305\|PubMed:33509932}.
P35606	COPB2	Y193	Sugiyama	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269\|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.
Q02750	MAP2K1	S248	SIGNOR	Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269\|PubMed:14737111, ECO:0000269\|PubMed:17101779, ECO:0000269\|PubMed:29433126}.
P60174	TPI1	S97	Sugiyama	Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)	Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269\|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250\|UniProtKB:P00939}.
Q5JR12	PPM1J	S93	SIGNOR	Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta)	None
Q9GZV5	WWTR1	S314	SIGNOR	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269\|PubMed:11118213, ECO:0000269\|PubMed:18227151, ECO:0000269\|PubMed:18568018, ECO:0000269\|PubMed:19010321, ECO:0000269\|PubMed:23911299}.
Q9C0C2	TNKS1BP1	S1046	Sugiyama	182 kDa tankyrase-1-binding protein	None
Q15139	PRKD1	Y252	Sugiyama	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250\|UniProtKB:Q62101, ECO:0000269\|PubMed:10523301, ECO:0000269\|PubMed:10764790, ECO:0000269\|PubMed:12505989, ECO:0000269\|PubMed:12637538, ECO:0000269\|PubMed:15471852, ECO:0000269\|PubMed:17442957, ECO:0000269\|PubMed:18332134, ECO:0000269\|PubMed:18509061, ECO:0000269\|PubMed:19135240, ECO:0000269\|PubMed:19211839, ECO:0000269\|PubMed:24623306}.

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reactome_id	name	p	-log10_p
R-HSA-8952158	RUNX3 regulates BCL2L11 (BIM) transcription	0.000007	5.156
R-HSA-9825895	Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ...	0.000073	4.136
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.000066	4.182
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.000118	3.928
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis...	0.000343	3.464
R-HSA-8863678	Neurodegenerative Diseases	0.000343	3.464
R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	0.000527	3.278
R-HSA-75153	Apoptotic execution phase	0.000750	3.125
R-HSA-156711	Polo-like kinase mediated events	0.001163	2.934
R-HSA-4419969	Depolymerization of the Nuclear Lamina	0.001163	2.934
R-HSA-69278	Cell Cycle, Mitotic	0.001382	2.860
R-HSA-352238	Breakdown of the nuclear lamina	0.001641	2.785
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.001672	2.777
R-HSA-2980766	Nuclear Envelope Breakdown	0.001911	2.719
R-HSA-9856651	MITF-M-dependent gene expression	0.001950	2.710
R-HSA-2995383	Initiation of Nuclear Envelope (NE) Reformation	0.002079	2.682
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	0.002262	2.645
R-HSA-9607240	FLT3 Signaling	0.002712	2.567
R-HSA-1839120	Signaling by FGFR1 amplification mutants	0.004443	2.352
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells	0.005203	2.284
R-HSA-1640170	Cell Cycle	0.004955	2.305
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	0.005737	2.241
R-HSA-8878159	Transcriptional regulation by RUNX3	0.005758	2.240
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	0.007553	2.122
R-HSA-162582	Signal Transduction	0.008427	2.074
R-HSA-177929	Signaling by EGFR	0.008907	2.050
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.009502	2.022
R-HSA-9700206	Signaling by ALK in cancer	0.009502	2.022
R-HSA-2028269	Signaling by Hippo	0.009507	2.022
R-HSA-176417	Phosphorylation of Emi1	0.010945	1.961
R-HSA-9614657	FOXO-mediated transcription of cell death genes	0.010711	1.970
R-HSA-5674499	Negative feedback regulation of MAPK pathway	0.010945	1.961
R-HSA-9758919	Epithelial-Mesenchymal Transition (EMT) during gastrulation	0.010945	1.961
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.010945	1.961
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.011998	1.921
R-HSA-9707616	Heme signaling	0.012704	1.896
R-HSA-69478	G2/M DNA replication checkpoint	0.013677	1.864
R-HSA-68886	M Phase	0.013827	1.859
R-HSA-428890	Role of ABL in ROBO-SLIT signaling	0.016672	1.778
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.016375	1.786
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	0.014959	1.825
R-HSA-5655302	Signaling by FGFR1 in disease	0.016205	1.790
R-HSA-68875	Mitotic Prophase	0.017129	1.766
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.016375	1.786
R-HSA-3214841	PKMTs methylate histone lysines	0.015146	1.820
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.015922	1.798
R-HSA-3700989	Transcriptional Regulation by TP53	0.015852	1.800
R-HSA-9730414	MITF-M-regulated melanocyte development	0.017342	1.761
R-HSA-5654689	PI-3K cascade:FGFR1	0.018006	1.745
R-HSA-8854214	TBC/RABGAPs	0.018458	1.734
R-HSA-68882	Mitotic Anaphase	0.018752	1.727
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.019241	1.716
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	0.019918	1.701
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.019726	1.705
R-HSA-69618	Mitotic Spindle Checkpoint	0.022811	1.642
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.022242	1.653
R-HSA-69620	Cell Cycle Checkpoints	0.022012	1.657
R-HSA-193704	p75 NTR receptor-mediated signalling	0.021949	1.659
R-HSA-9839394	TGFBR3 expression	0.023426	1.630
R-HSA-9663199	Defective DNA double strand break response due to BRCA1 loss of function	0.038251	1.417
R-HSA-9699150	Defective DNA double strand break response due to BARD1 loss of function	0.038251	1.417
R-HSA-5632968	Defective Mismatch Repair Associated With MSH6	0.038251	1.417
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.056825	1.245
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.056825	1.245
R-HSA-5619054	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit...	0.056825	1.245
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.056825	1.245
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E...	0.056825	1.245
R-HSA-5602636	IKBKB deficiency causes SCID	0.056825	1.245
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.092909	1.032
R-HSA-8853336	Signaling by plasma membrane FGFR1 fusions	0.092909	1.032
R-HSA-8865999	MET activates PTPN11	0.092909	1.032
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	0.092909	1.032
R-HSA-9944971	Loss of Function of KMT2D in Kabuki Syndrome	0.092909	1.032
R-HSA-191650	Regulation of gap junction activity	0.110431	0.957
R-HSA-165181	Inhibition of TSC complex formation by PKB	0.110431	0.957
R-HSA-9652169	Signaling by MAP2K mutants	0.110431	0.957
R-HSA-8875555	MET activates RAP1 and RAC1	0.027123	1.567
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.031062	1.508
R-HSA-74713	IRS activation	0.127616	0.894
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	0.127616	0.894
R-HSA-9673768	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	0.127616	0.894
R-HSA-9706377	FLT3 signaling by CBL mutants	0.127616	0.894
R-HSA-9623433	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	0.035210	1.453
R-HSA-1839122	Signaling by activated point mutants of FGFR1	0.035210	1.453
R-HSA-69109	Leading Strand Synthesis	0.039560	1.403
R-HSA-69091	Polymerase switching	0.039560	1.403
R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.144470	0.840
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	0.161000	0.793
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.058788	1.231
R-HSA-176412	Phosphorylation of the APC/C	0.058788	1.231
R-HSA-8851907	MET activates PI3K/AKT signaling	0.177211	0.752
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.177211	0.752
R-HSA-9732724	IFNG signaling activates MAPKs	0.177211	0.752
R-HSA-9031525	NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	0.177211	0.752
R-HSA-112412	SOS-mediated signalling	0.177211	0.752
R-HSA-9632974	NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	0.177211	0.752
R-HSA-9031528	NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo...	0.177211	0.752
R-HSA-9726840	SHOC2 M1731 mutant abolishes MRAS complex function	0.177211	0.752
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anapha...	0.064009	1.194
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.064009	1.194
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	0.069380	1.159
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.069380	1.159
R-HSA-444257	RSK activation	0.193110	0.714
R-HSA-9660537	Signaling by MRAS-complex mutants	0.193110	0.714
R-HSA-196025	Formation of annular gap junctions	0.193110	0.714
R-HSA-1169092	Activation of RAS in B cells	0.193110	0.714
R-HSA-190370	FGFR1b ligand binding and activation	0.193110	0.714
R-HSA-8875656	MET receptor recycling	0.193110	0.714
R-HSA-9028335	Activated NTRK2 signals through PI3K	0.193110	0.714
R-HSA-9726842	Gain-of-function MRAS complexes activate RAF signaling	0.193110	0.714
R-HSA-180292	GAB1 signalosome	0.074893	1.126
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.074893	1.126
R-HSA-5656169	Termination of translesion DNA synthesis	0.031876	1.497
R-HSA-170984	ARMS-mediated activation	0.208702	0.680
R-HSA-190873	Gap junction degradation	0.208702	0.680
R-HSA-9700645	ALK mutants bind TKIs	0.208702	0.680
R-HSA-182971	EGFR downregulation	0.036621	1.436
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.092208	1.035
R-HSA-110056	MAPK3 (ERK1) activation	0.223994	0.650
R-HSA-5654687	Downstream signaling of activated FGFR1	0.049962	1.301
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.049962	1.301
R-HSA-350054	Notch-HLH transcription pathway	0.104331	0.982
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.116856	0.932
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	0.253701	0.596
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.123254	0.909
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.268126	0.572
R-HSA-5674135	MAP2K and MAPK activation	0.072017	1.143
R-HSA-9656223	Signaling by RAF1 mutants	0.072017	1.143
R-HSA-194441	Metabolism of non-coding RNA	0.043388	1.363
R-HSA-191859	snRNP Assembly	0.043388	1.363
R-HSA-9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	0.282273	0.549
R-HSA-9933947	Formation of the non-canonical BAF (ncBAF) complex	0.282273	0.549
R-HSA-9649948	Signaling downstream of RAS mutants	0.089990	1.046
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	0.156378	0.806
R-HSA-9933939	Formation of the polybromo-BAF (pBAF) complex	0.296148	0.528
R-HSA-69166	Removal of the Flap Intermediate	0.296148	0.528
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	0.163193	0.787
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	0.163193	0.787
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.038360	1.416
R-HSA-141424	Amplification of signal from the kinetochores	0.038360	1.416
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	0.309755	0.509
R-HSA-1855170	IPs transport between nucleus and cytosol	0.176974	0.752
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.176974	0.752
R-HSA-390522	Striated Muscle Contraction	0.183932	0.735
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.183932	0.735
R-HSA-5656121	Translesion synthesis by POLI	0.323100	0.491
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	0.323100	0.491
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.075522	1.122
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	0.126409	0.898
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.130742	0.884
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.130742	0.884
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.101036	0.996
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.226357	0.645
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.233506	0.632
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.233506	0.632
R-HSA-167161	HIV Transcription Initiation	0.247841	0.606
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.247841	0.606
R-HSA-8854518	AURKA Activation by TPX2	0.176661	0.753
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	0.290924	0.536
R-HSA-1989781	PPARA activates gene expression	0.250259	0.602
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.257525	0.589
R-HSA-453276	Regulation of mitotic cell cycle	0.201087	0.697
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	0.201087	0.697
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	0.157770	0.802
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.292253	0.534
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.292253	0.534
R-HSA-69186	Lagging Strand Synthesis	0.092208	1.035
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.098216	1.008
R-HSA-72163	mRNA Splicing - Major Pathway	0.238361	0.623
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa...	0.068636	1.163
R-HSA-73893	DNA Damage Bypass	0.101584	0.993
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.292253	0.534
R-HSA-190242	FGFR1 ligand binding and activation	0.074893	1.126
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.089990	1.046
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.089990	1.046
R-HSA-69183	Processive synthesis on the lagging strand	0.309755	0.509
R-HSA-418885	DCC mediated attractive signaling	0.053724	1.270
R-HSA-446107	Type I hemidesmosome assembly	0.193110	0.714
R-HSA-8875878	MET promotes cell motility	0.058948	1.230
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.116856	0.932
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.212111	0.673
R-HSA-6802957	Oncogenic MAPK signaling	0.036922	1.433
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.276573	0.558
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.130742	0.884
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.069380	1.159
R-HSA-69190	DNA strand elongation	0.039121	1.408
R-HSA-198203	PI3K/AKT activation	0.223994	0.650
R-HSA-110312	Translesion synthesis by REV1	0.309755	0.509
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.032712	1.485
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.034579	1.461
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.039121	1.408
R-HSA-6802949	Signaling by RAS mutants	0.089990	1.046
R-HSA-5654736	Signaling by FGFR1	0.037755	1.423
R-HSA-933542	TRAF6 mediated NF-kB activation	0.116856	0.932
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.060164	1.221
R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.268126	0.572
R-HSA-4641265	Repression of WNT target genes	0.268126	0.572
R-HSA-73776	RNA Polymerase II Promoter Escape	0.262204	0.581
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.127616	0.894
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.069380	1.159
R-HSA-354192	Integrin signaling	0.041707	1.380
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.055873	1.253
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.123254	0.909
R-HSA-190373	FGFR1c ligand binding and activation	0.282273	0.549
R-HSA-1221632	Meiotic synapsis	0.117905	0.928
R-HSA-5673000	RAF activation	0.190928	0.719
R-HSA-5696400	Dual Incision in GG-NER	0.190928	0.719
R-HSA-9843745	Adipogenesis	0.070156	1.154
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.247841	0.606
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.247841	0.606
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.305240	0.515
R-HSA-9614085	FOXO-mediated transcription	0.169366	0.771
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.246646	0.608
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	0.309755	0.509
R-HSA-9924644	Developmental Lineages of the Mammary Gland	0.072915	1.137
R-HSA-2467813	Separation of Sister Chromatids	0.147801	0.830
R-HSA-72172	mRNA Splicing	0.273932	0.562
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.232805	0.633
R-HSA-8951430	RUNX3 regulates WNT signaling	0.177211	0.752
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	0.223994	0.650
R-HSA-9614399	Regulation of localization of FOXO transcription factors	0.238992	0.622
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.086257	1.064
R-HSA-165159	MTOR signalling	0.255021	0.593
R-HSA-525793	Myogenesis	0.129735	0.887
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.268126	0.572
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	0.233506	0.632
R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	0.233506	0.632
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.240669	0.619
R-HSA-5693538	Homology Directed Repair	0.118096	0.928
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P...	0.208702	0.680
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.296148	0.528
R-HSA-69239	Synthesis of DNA	0.204303	0.690
R-HSA-9758274	Regulation of NF-kappa B signaling	0.323100	0.491
R-HSA-5693532	DNA Double-Strand Break Repair	0.120208	0.920
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.181479	0.741
R-HSA-169893	Prolonged ERK activation events	0.058788	1.231
R-HSA-68877	Mitotic Prometaphase	0.058264	1.235
R-HSA-190827	Transport of connexins along the secretory pathway	0.056825	1.245
R-HSA-5632928	Defective Mismatch Repair Associated With MSH2	0.056825	1.245
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.075043	1.125
R-HSA-209560	NF-kB is activated and signals survival	0.035210	1.453
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.144470	0.840
R-HSA-5603029	IkBA variant leads to EDA-ID	0.144470	0.840
R-HSA-1483101	Synthesis of PS	0.144470	0.840
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.144470	0.840
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	0.044102	1.356
R-HSA-2470946	Cohesin Loading onto Chromatin	0.177211	0.752
R-HSA-428543	Inactivation of CDC42 and RAC1	0.208702	0.680
R-HSA-176974	Unwinding of DNA	0.208702	0.680
R-HSA-6803544	Ion influx/efflux at host-pathogen interface	0.223994	0.650
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.282273	0.549
R-HSA-2428928	IRS-related events triggered by IGF1R	0.047391	1.324
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.156378	0.806
R-HSA-1855191	Synthesis of IPs in the nucleus	0.296148	0.528
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.309755	0.509
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	0.031615	1.500
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.323100	0.491
R-HSA-9603798	Class I peroxisomal membrane protein import	0.323100	0.491
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.212111	0.673
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.147376	0.832
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.276573	0.558
R-HSA-5358508	Mismatch Repair	0.074893	1.126
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.247841	0.606
R-HSA-5654726	Negative regulation of FGFR1 signaling	0.041707	1.380
R-HSA-69275	G2/M Transition	0.049838	1.302
R-HSA-193639	p75NTR signals via NF-kB	0.053724	1.270
R-HSA-453274	Mitotic G2-G2/M phases	0.052159	1.283
R-HSA-6806834	Signaling by MET	0.095057	1.022
R-HSA-209543	p75NTR recruits signalling complexes	0.039560	1.403
R-HSA-112399	IRS-mediated signalling	0.039583	1.402
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.239433	0.621
R-HSA-1839124	FGFR1 mutant receptor activation	0.041707	1.380
R-HSA-9909396	Circadian clock	0.071947	1.143
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.161910	0.791
R-HSA-190236	Signaling by FGFR	0.165623	0.781
R-HSA-74749	Signal attenuation	0.223994	0.650
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	0.156378	0.806
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.233506	0.632
R-HSA-5260271	Diseases of Immune System	0.233506	0.632
R-HSA-69306	DNA Replication	0.243048	0.614
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.267601	0.573
R-HSA-5684996	MAPK1/MAPK3 signaling	0.093420	1.030
R-HSA-139915	Activation of PUMA and translocation to mitochondria	0.177211	0.752
R-HSA-9603381	Activated NTRK3 signals through PI3K	0.177211	0.752
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.193110	0.714
R-HSA-74751	Insulin receptor signalling cascade	0.053768	1.269
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.183932	0.735
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	0.058264	1.235
R-HSA-5673001	RAF/MAP kinase cascade	0.083670	1.077
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.050703	1.295
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	0.048826	1.311
R-HSA-1500620	Meiosis	0.272838	0.564
R-HSA-73894	DNA Repair	0.211216	0.675
R-HSA-9913351	Formation of the dystrophin-glycoprotein complex (DGC)	0.036621	1.436
R-HSA-2428924	IGF1R signaling cascade	0.053768	1.269
R-HSA-5675221	Negative regulation of MAPK pathway	0.247841	0.606
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.068636	1.163
R-HSA-9006936	Signaling by TGFB family members	0.137453	0.862
R-HSA-190704	Oligomerization of connexins into connexons	0.056825	1.245
R-HSA-5423599	Diseases of Mismatch Repair (MMR)	0.092909	1.032
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	0.161000	0.793
R-HSA-9706369	Negative regulation of FLT3	0.058788	1.231
R-HSA-9675151	Disorders of Developmental Biology	0.064009	1.194
R-HSA-9619229	Activation of RAC1 downstream of NMDARs	0.208702	0.680
R-HSA-1181150	Signaling by NODAL	0.086314	1.064
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	0.110546	0.956
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	0.309755	0.509
R-HSA-69473	G2/M DNA damage checkpoint	0.216106	0.665
R-HSA-9734767	Developmental Cell Lineages	0.191147	0.719
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.129735	0.887
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.055992	1.252
R-HSA-187687	Signalling to ERKs	0.197960	0.703
R-HSA-9664873	Pexophagy	0.223994	0.650
R-HSA-170968	Frs2-mediated activation	0.282273	0.549
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.097655	1.010
R-HSA-5683057	MAPK family signaling cascades	0.107500	0.969
R-HSA-1226099	Signaling by FGFR in disease	0.078177	1.107
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.208702	0.680
R-HSA-9842663	Signaling by LTK	0.268126	0.572
R-HSA-1502540	Signaling by Activin	0.309755	0.509
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	0.197960	0.703
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	0.290924	0.536
R-HSA-9612973	Autophagy	0.253886	0.595
R-HSA-74752	Signaling by Insulin receptor	0.140309	0.853
R-HSA-373752	Netrin-1 signaling	0.269389	0.570
R-HSA-5654743	Signaling by FGFR4	0.262204	0.581
R-HSA-69481	G2/M Checkpoints	0.146677	0.834
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.161000	0.793
R-HSA-392517	Rap1 signalling	0.080540	1.094
R-HSA-8934903	Receptor Mediated Mitophagy	0.223994	0.650
R-HSA-193648	NRAGE signals death through JNK	0.037755	1.423
R-HSA-205043	NRIF signals cell death from the nucleus	0.296148	0.528
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	0.296148	0.528
R-HSA-180746	Nuclear import of Rev protein	0.190928	0.719
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.132034	0.879
R-HSA-5654741	Signaling by FGFR3	0.276573	0.558
R-HSA-1295596	Spry regulation of FGF signaling	0.309755	0.509
R-HSA-1483249	Inositol phosphate metabolism	0.224560	0.649
R-HSA-9675135	Diseases of DNA repair	0.283752	0.547
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.092208	1.035
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.092208	1.035
R-HSA-9007101	Rab regulation of trafficking	0.045053	1.346
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	0.110431	0.957
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.161000	0.793
R-HSA-8948747	Regulation of PTEN localization	0.177211	0.752
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	0.193110	0.714
R-HSA-425986	Sodium/Proton exchangers	0.193110	0.714
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.208702	0.680
R-HSA-2465910	MASTL Facilitates Mitotic Progression	0.208702	0.680
R-HSA-425381	Bicarbonate transporters	0.238992	0.622
R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.110546	0.956
R-HSA-2514853	Condensation of Prometaphase Chromosomes	0.253701	0.596
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.253701	0.596
R-HSA-937039	IRAK1 recruits IKK complex	0.268126	0.572
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.268126	0.572
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.282273	0.549
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic...	0.323100	0.491
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.226357	0.645
R-HSA-177243	Interactions of Rev with host cellular proteins	0.233506	0.632
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.233506	0.632
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.240669	0.619
R-HSA-1632852	Macroautophagy	0.197727	0.704
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.178798	0.748
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.245308	0.610
R-HSA-1643713	Signaling by EGFR in Cancer	0.129735	0.887
R-HSA-4839726	Chromatin organization	0.273524	0.563
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.221165	0.655
R-HSA-74160	Gene expression (Transcription)	0.315933	0.500
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	0.204503	0.689
R-HSA-9758941	Gastrulation	0.228800	0.641
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.069380	1.159
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.069380	1.159
R-HSA-430116	GP1b-IX-V activation signalling	0.208702	0.680
R-HSA-9617629	Regulation of FOXO transcriptional activity by acetylation	0.268126	0.572
R-HSA-114508	Effects of PIP2 hydrolysis	0.183932	0.735
R-HSA-194138	Signaling by VEGF	0.292253	0.534
R-HSA-5205647	Mitophagy	0.190928	0.719
R-HSA-9645723	Diseases of programmed cell death	0.042878	1.368
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.212111	0.673
R-HSA-114452	Activation of BH3-only proteins	0.156378	0.806
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen...	0.144470	0.840
R-HSA-9697154	Disorders of Nervous System Development	0.268126	0.572
R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.268126	0.572
R-HSA-9005895	Pervasive developmental disorders	0.268126	0.572
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.282273	0.549
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.282273	0.549
R-HSA-5655291	Signaling by FGFR4 in disease	0.296148	0.528
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.219224	0.659
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.283752	0.547
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.155781	0.807
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.267601	0.573
R-HSA-9663891	Selective autophagy	0.293882	0.532
R-HSA-9705683	SARS-CoV-2-host interactions	0.212951	0.672
R-HSA-76002	Platelet activation, signaling and aggregation	0.218593	0.660
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.278085	0.556
R-HSA-8941326	RUNX2 regulates bone development	0.205022	0.688
R-HSA-1266738	Developmental Biology	0.044024	1.356
R-HSA-446652	Interleukin-1 family signaling	0.239463	0.621
R-HSA-445144	Signal transduction by L1	0.086314	1.064
R-HSA-1474165	Reproduction	0.158867	0.799
R-HSA-8878171	Transcriptional regulation by RUNX1	0.207457	0.683
R-HSA-9860276	SLC15A4:TASL-dependent IRF5 activation	0.144470	0.840
R-HSA-109704	PI3K Cascade	0.027828	1.556
R-HSA-5578768	Physiological factors	0.296148	0.528
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.226357	0.645
R-HSA-1227986	Signaling by ERBB2	0.148574	0.828
R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.157770	0.802
R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	0.309755	0.509
R-HSA-73884	Base Excision Repair	0.304447	0.516
R-HSA-6783310	Fanconi Anemia Pathway	0.276573	0.558
R-HSA-9855142	Cellular responses to mechanical stimuli	0.232805	0.633
R-HSA-9839373	Signaling by TGFBR3	0.089990	1.046
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ...	0.197960	0.703
R-HSA-373760	L1CAM interactions	0.249508	0.603
R-HSA-73887	Death Receptor Signaling	0.053630	1.271
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	0.268126	0.572
R-HSA-1433559	Regulation of KIT signaling	0.296148	0.528
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.221165	0.655
R-HSA-159418	Recycling of bile acids and salts	0.176974	0.752
R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.323100	0.491
R-HSA-3247509	Chromatin modifying enzymes	0.229744	0.639
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.116716	0.933
R-HSA-1227990	Signaling by ERBB2 in Cancer	0.156378	0.806
R-HSA-198323	AKT phosphorylates targets in the cytosol	0.268126	0.572
R-HSA-9827857	Specification of primordial germ cells	0.069380	1.159
R-HSA-2586552	Signaling by Leptin	0.223994	0.650
R-HSA-1257604	PIP3 activates AKT signaling	0.091988	1.036
R-HSA-391160	Signal regulatory protein family interactions	0.296148	0.528
R-HSA-446353	Cell-extracellular matrix interactions	0.309755	0.509
R-HSA-109581	Apoptosis	0.026363	1.579
R-HSA-5357905	Regulation of TNFR1 signaling	0.283752	0.547
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.266575	0.574
R-HSA-5633007	Regulation of TP53 Activity	0.062008	1.208
R-HSA-9926550	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh...	0.074893	1.126
R-HSA-6794362	Protein-protein interactions at synapses	0.272838	0.564
R-HSA-9711123	Cellular response to chemical stress	0.203438	0.692
R-HSA-9006925	Intracellular signaling by second messengers	0.100312	0.999
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.136293	0.866
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	0.095057	1.022
R-HSA-5357801	Programmed Cell Death	0.076182	1.118
R-HSA-9008059	Interleukin-37 signaling	0.156378	0.806
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.162433	0.789
R-HSA-1280215	Cytokine Signaling in Immune system	0.306361	0.514
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.262204	0.581
R-HSA-416482	G alpha (12/13) signalling events	0.236478	0.626
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.031505	1.502
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	0.097655	1.010
R-HSA-8953750	Transcriptional Regulation by E2F6	0.226357	0.645
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.241623	0.617
R-HSA-449147	Signaling by Interleukins	0.281552	0.550
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	0.047128	1.327
R-HSA-1592230	Mitochondrial biogenesis	0.115396	0.938
R-HSA-1059683	Interleukin-6 signaling	0.282273	0.549
R-HSA-9707564	Cytoprotection by HMOX1	0.104089	0.983
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.232051	0.634
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.326607	0.486
R-HSA-72187	mRNA 3'-end processing	0.326607	0.486
R-HSA-6794361	Neurexins and neuroligins	0.326607	0.486
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	0.333693	0.477
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	0.333693	0.477
R-HSA-445355	Smooth Muscle Contraction	0.333693	0.477
R-HSA-5655862	Translesion synthesis by POLK	0.336188	0.473
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	0.336188	0.473
R-HSA-918233	TRAF3-dependent IRF activation pathway	0.336188	0.473
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.336188	0.473
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.336188	0.473
R-HSA-73857	RNA Polymerase II Transcription	0.345675	0.461
R-HSA-1852241	Organelle biogenesis and maintenance	0.345721	0.461
R-HSA-6807878	COPI-mediated anterograde transport	0.346784	0.460
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.349023	0.457
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	0.349023	0.457
R-HSA-1963642	PI3K events in ERBB2 signaling	0.349023	0.457
R-HSA-9909505	Modulation of host responses by IFN-stimulated genes	0.349023	0.457
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.349023	0.457
R-HSA-5210891	Uptake and function of anthrax toxins	0.349023	0.457
R-HSA-212165	Epigenetic regulation of gene expression	0.354449	0.450
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.354812	0.450
R-HSA-75893	TNF signaling	0.354812	0.450
R-HSA-212436	Generic Transcription Pathway	0.355830	0.449
R-HSA-190872	Transport of connexons to the plasma membrane	0.361612	0.442
R-HSA-3928664	Ephrin signaling	0.361612	0.442
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.361612	0.442
R-HSA-73980	RNA Polymerase III Transcription Termination	0.361612	0.442
R-HSA-9613829	Chaperone Mediated Autophagy	0.361612	0.442
R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.361612	0.442
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.361612	0.442
R-HSA-8849932	Synaptic adhesion-like molecules	0.361612	0.442
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.361801	0.442
R-HSA-70171	Glycolysis	0.367889	0.434
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.368761	0.433
R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu...	0.368761	0.433
R-HSA-6782135	Dual incision in TC-NER	0.368761	0.433
R-HSA-9020702	Interleukin-1 signaling	0.373149	0.428
R-HSA-912631	Regulation of signaling by CBL	0.373957	0.427
R-HSA-5654710	PI-3K cascade:FGFR3	0.373957	0.427
R-HSA-9709603	Impaired BRCA2 binding to PALB2	0.373957	0.427
R-HSA-110320	Translesion Synthesis by POLH	0.373957	0.427
R-HSA-9754189	Germ layer formation at gastrulation	0.373957	0.427
R-HSA-9856532	Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	0.373957	0.427
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.373957	0.427
R-HSA-113510	E2F mediated regulation of DNA replication	0.373957	0.427
R-HSA-9834899	Specification of the neural plate border	0.373957	0.427
R-HSA-844456	The NLRP3 inflammasome	0.373957	0.427
R-HSA-9913635	Strand-asynchronous mitochondrial DNA replication	0.373957	0.427
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.375691	0.425
R-HSA-180786	Extension of Telomeres	0.375691	0.425
R-HSA-429914	Deadenylation-dependent mRNA decay	0.375691	0.425
R-HSA-1483255	PI Metabolism	0.378400	0.422
R-HSA-162599	Late Phase of HIV Life Cycle	0.379746	0.421
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.382590	0.417
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.382590	0.417
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.382590	0.417
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.382590	0.417
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.382590	0.417
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	0.382590	0.417
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.382590	0.417
R-HSA-5654720	PI-3K cascade:FGFR4	0.386065	0.413
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	0.386065	0.413
R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	0.386065	0.413
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.386065	0.413
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.386065	0.413
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	0.386065	0.413
R-HSA-9823730	Formation of definitive endoderm	0.386065	0.413
R-HSA-5620916	VxPx cargo-targeting to cilium	0.386065	0.413
R-HSA-6807004	Negative regulation of MET activity	0.386065	0.413
R-HSA-140875	Common Pathway of Fibrin Clot Formation	0.386065	0.413
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.388874	0.410
R-HSA-9860931	Response of endothelial cells to shear stress	0.388874	0.410
R-HSA-168325	Viral Messenger RNA Synthesis	0.389457	0.410
R-HSA-73856	RNA Polymerase II Transcription Termination	0.389457	0.410
R-HSA-211976	Endogenous sterols	0.389457	0.410
R-HSA-450294	MAP kinase activation	0.389457	0.410
R-HSA-9793380	Formation of paraxial mesoderm	0.389457	0.410
R-HSA-5619507	Activation of HOX genes during differentiation	0.394095	0.404
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	0.394095	0.404
R-HSA-9675108	Nervous system development	0.395856	0.402
R-HSA-375165	NCAM signaling for neurite out-growth	0.396289	0.402
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.396289	0.402
R-HSA-6784531	tRNA processing in the nucleus	0.396289	0.402
R-HSA-5602498	MyD88 deficiency (TLR2/4)	0.397939	0.400
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.397939	0.400
R-HSA-5696398	Nucleotide Excision Repair	0.399305	0.399
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	0.403086	0.395
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.403086	0.395
R-HSA-8848021	Signaling by PTK6	0.403086	0.395
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.403086	0.395
R-HSA-8953854	Metabolism of RNA	0.405462	0.392
R-HSA-69242	S Phase	0.405959	0.392
R-HSA-166520	Signaling by NTRKs	0.405959	0.392
R-HSA-9609690	HCMV Early Events	0.408942	0.388
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	0.409584	0.388
R-HSA-8876384	Listeria monocytogenes entry into host cells	0.409584	0.388
R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.409584	0.388
R-HSA-9671555	Signaling by PDGFR in disease	0.409584	0.388
R-HSA-936837	Ion transport by P-type ATPases	0.409846	0.387
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	0.409846	0.387
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati...	0.416569	0.380
R-HSA-9938206	Developmental Lineage of Mammary Stem Cells	0.421004	0.376
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.421004	0.376
R-HSA-112409	RAF-independent MAPK1/3 activation	0.421004	0.376
R-HSA-166208	mTORC1-mediated signalling	0.421004	0.376
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specif...	0.421004	0.376
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in ...	0.421004	0.376
R-HSA-422475	Axon guidance	0.425181	0.371
R-HSA-5693606	DNA Double Strand Break Response	0.429898	0.367
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.429898	0.367
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.431957	0.365
R-HSA-199991	Membrane Trafficking	0.432009	0.365
R-HSA-200425	Carnitine shuttle	0.432205	0.364
R-HSA-982772	Growth hormone receptor signaling	0.432205	0.364
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.436502	0.360
R-HSA-167172	Transcription of the HIV genome	0.436502	0.360
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	0.443065	0.354
R-HSA-5621575	CD209 (DC-SIGN) signaling	0.443189	0.353
R-HSA-429947	Deadenylation of mRNA	0.443189	0.353
R-HSA-6783589	Interleukin-6 family signaling	0.443189	0.353
R-HSA-162587	HIV Life Cycle	0.444845	0.352
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	0.449585	0.347
R-HSA-9764560	Regulation of CDH1 Gene Transcription	0.449585	0.347
R-HSA-448424	Interleukin-17 signaling	0.449585	0.347
R-HSA-5654695	PI-3K cascade:FGFR2	0.453962	0.343
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD...	0.453962	0.343
R-HSA-9932451	SWI/SNF chromatin remodelers	0.453962	0.343
R-HSA-9932444	ATP-dependent chromatin remodelers	0.453962	0.343
R-HSA-2160916	Hyaluronan degradation	0.453962	0.343
R-HSA-1266695	Interleukin-7 signaling	0.453962	0.343
R-HSA-5628897	TP53 Regulates Metabolic Genes	0.455651	0.341
R-HSA-5578749	Transcriptional regulation by small RNAs	0.462495	0.335
R-HSA-8874081	MET activates PTK2 signaling	0.464527	0.333
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	0.464527	0.333
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	0.464527	0.333
R-HSA-5689901	Metalloprotease DUBs	0.464527	0.333
R-HSA-8934593	Regulation of RUNX1 Expression and Activity	0.464527	0.333
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.468883	0.329
R-HSA-69052	Switching of origins to a post-replicative state	0.468883	0.329
R-HSA-70326	Glucose metabolism	0.470646	0.327
R-HSA-397014	Muscle contraction	0.473141	0.325
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.474888	0.323
R-HSA-445095	Interaction between L1 and Ankyrins	0.474888	0.323
R-HSA-201451	Signaling by BMP	0.474888	0.323
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	0.474888	0.323
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	0.474888	0.323
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.474888	0.323
R-HSA-5655332	Signaling by FGFR3 in disease	0.474888	0.323
R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.474888	0.323
R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.474888	0.323
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.475226	0.323
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.480538	0.318
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.480538	0.318
R-HSA-8878166	Transcriptional regulation by RUNX2	0.480538	0.318
R-HSA-380287	Centrosome maturation	0.481523	0.317
R-HSA-1169408	ISG15 antiviral mechanism	0.481523	0.317
R-HSA-1500931	Cell-Cell communication	0.482532	0.316
R-HSA-5654732	Negative regulation of FGFR3 signaling	0.485049	0.314
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	0.485049	0.314
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.485049	0.314
R-HSA-5620971	Pyroptosis	0.485049	0.314
R-HSA-622312	Inflammasomes	0.485049	0.314
R-HSA-1980143	Signaling by NOTCH1	0.487773	0.312
R-HSA-9020591	Interleukin-12 signaling	0.487773	0.312
R-HSA-73886	Chromosome Maintenance	0.490344	0.309
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.493976	0.306
R-HSA-9615710	Late endosomal microautophagy	0.495014	0.305
R-HSA-9709570	Impaired BRCA2 binding to RAD51	0.495014	0.305
R-HSA-5654733	Negative regulation of FGFR4 signaling	0.495014	0.305
R-HSA-5654708	Downstream signaling of activated FGFR3	0.495014	0.305
R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.495014	0.305
R-HSA-9006335	Signaling by Erythropoietin	0.495014	0.305
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.495213	0.305
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.495213	0.305
R-HSA-383280	Nuclear Receptor transcription pathway	0.500132	0.301
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	0.504787	0.297
R-HSA-68962	Activation of the pre-replicative complex	0.504787	0.297
R-HSA-2424491	DAP12 signaling	0.504787	0.297
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.504787	0.297
R-HSA-5654716	Downstream signaling of activated FGFR4	0.504787	0.297
R-HSA-8863795	Downregulation of ERBB2 signaling	0.504787	0.297
R-HSA-9909648	Regulation of PD-L1(CD274) expression	0.511825	0.291
R-HSA-5654738	Signaling by FGFR2	0.512298	0.290
R-HSA-9833482	PKR-mediated signaling	0.512298	0.290
R-HSA-9820960	Respiratory syncytial virus (RSV) attachment and entry	0.514371	0.289
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	0.514371	0.289
R-HSA-9833109	Evasion by RSV of host interferon responses	0.514371	0.289
R-HSA-5693607	Processing of DNA double-strand break ends	0.518308	0.285
R-HSA-9675126	Diseases of mitotic cell cycle	0.523771	0.281
R-HSA-114608	Platelet degranulation	0.523925	0.281
R-HSA-446728	Cell junction organization	0.524732	0.280
R-HSA-187037	Signaling by NTRK1 (TRKA)	0.528624	0.277
R-HSA-442742	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	0.532989	0.273
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.532989	0.273
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.532989	0.273
R-HSA-176187	Activation of ATR in response to replication stress	0.532989	0.273
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.532989	0.273
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	0.532989	0.273
R-HSA-9733709	Cardiogenesis	0.532989	0.273
R-HSA-9022692	Regulation of MECP2 expression and activity	0.532989	0.273
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.536040	0.271
R-HSA-5693537	Resolution of D-Loop Structures	0.542029	0.266
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	0.542029	0.266
R-HSA-9768727	Regulation of CDH1 posttranslational processing and trafficking to plasma membra...	0.542029	0.266
R-HSA-5223345	Miscellaneous transport and binding events	0.542029	0.266
R-HSA-168256	Immune System	0.550680	0.259
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	0.550895	0.259
R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	0.550895	0.259
R-HSA-190861	Gap junction assembly	0.550895	0.259
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	0.550895	0.259
R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	0.550895	0.259
R-HSA-1980145	Signaling by NOTCH2	0.550895	0.259
R-HSA-5654727	Negative regulation of FGFR2 signaling	0.550895	0.259
R-HSA-2142845	Hyaluronan metabolism	0.550895	0.259
R-HSA-5686938	Regulation of TLR by endogenous ligand	0.550895	0.259
R-HSA-168638	NOD1/2 Signaling Pathway	0.550895	0.259
R-HSA-381038	XBP1(S) activates chaperone genes	0.553319	0.257
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.556262	0.255
R-HSA-438064	Post NMDA receptor activation events	0.558977	0.253
R-HSA-447115	Interleukin-12 family signaling	0.558977	0.253
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	0.559589	0.252
R-HSA-5654696	Downstream signaling of activated FGFR2	0.559589	0.252
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.559589	0.252
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.564584	0.248
R-HSA-8853659	RET signaling	0.568116	0.246
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.568116	0.246
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.568116	0.246
R-HSA-114604	GPVI-mediated activation cascade	0.568116	0.246
R-HSA-74158	RNA Polymerase III Transcription	0.568116	0.246
R-HSA-6804757	Regulation of TP53 Degradation	0.568116	0.246
R-HSA-9682385	FLT3 signaling in disease	0.568116	0.246
R-HSA-1236974	ER-Phagosome pathway	0.570140	0.244
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.575645	0.240
R-HSA-1296072	Voltage gated Potassium channels	0.576479	0.239
R-HSA-933541	TRAF6 mediated IRF7 activation	0.576479	0.239
R-HSA-2142789	Ubiquinol biosynthesis	0.576479	0.239
R-HSA-5689896	Ovarian tumor domain proteases	0.576479	0.239
R-HSA-8948216	Collagen chain trimerization	0.576479	0.239
R-HSA-196757	Metabolism of folate and pterines	0.576479	0.239
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	0.578542	0.238
R-HSA-9694516	SARS-CoV-2 Infection	0.580972	0.236
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.584679	0.233
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.584679	0.233
R-HSA-9958790	SLC-mediated transport of inorganic anions	0.584679	0.233
R-HSA-381070	IRE1alpha activates chaperones	0.586499	0.232
R-HSA-2682334	EPH-Ephrin signaling	0.591849	0.228
R-HSA-201556	Signaling by ALK	0.592722	0.227
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.592722	0.227
R-HSA-68867	Assembly of the pre-replicative complex	0.597147	0.224
R-HSA-202433	Generation of second messenger molecules	0.600609	0.221
R-HSA-1251985	Nuclear signaling by ERBB4	0.600609	0.221
R-HSA-9646399	Aggrephagy	0.600609	0.221
R-HSA-1280218	Adaptive Immune System	0.604813	0.218
R-HSA-9609646	HCMV Infection	0.606461	0.217
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.607589	0.216
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	0.608344	0.216
R-HSA-8853884	Transcriptional Regulation by VENTX	0.608344	0.216
R-HSA-5218920	VEGFR2 mediated vascular permeability	0.608344	0.216
R-HSA-8856828	Clathrin-mediated endocytosis	0.608531	0.216
R-HSA-6811438	Intra-Golgi traffic	0.615930	0.210
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.617824	0.209
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.619076	0.208
R-HSA-389948	Co-inhibition by PD-1	0.619076	0.208
R-HSA-5688426	Deubiquitination	0.622533	0.206
R-HSA-157579	Telomere Maintenance	0.622865	0.206
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	0.623369	0.205
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.623369	0.205
R-HSA-199977	ER to Golgi Anterograde Transport	0.625019	0.204
R-HSA-388841	Regulation of T cell activation by CD28 family	0.625701	0.204
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.627854	0.202
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.627854	0.202
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.627854	0.202
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.629066	0.201
R-HSA-1433557	Signaling by SCF-KIT	0.630665	0.200
R-HSA-192105	Synthesis of bile acids and bile salts	0.632792	0.199
R-HSA-190828	Gap junction trafficking	0.637820	0.195
R-HSA-2172127	DAP12 interactions	0.637820	0.195
R-HSA-3928662	EPHB-mediated forward signaling	0.637820	0.195
R-HSA-3214858	RMTs methylate histone arginines	0.637820	0.195
R-HSA-9755511	KEAP1-NFE2L2 pathway	0.641026	0.193
R-HSA-9009391	Extra-nuclear estrogen signaling	0.642514	0.192
R-HSA-774815	Nucleosome assembly	0.644836	0.191
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	0.644836	0.191
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.644836	0.191
R-HSA-1489509	DAG and IP3 signaling	0.644836	0.191
R-HSA-9842860	Regulation of endogenous retroelements	0.647299	0.189
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	0.647299	0.189
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.647299	0.189
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	0.651717	0.186
R-HSA-2299718	Condensation of Prophase Chromosomes	0.651717	0.186
R-HSA-9664424	Cell recruitment (pro-inflammatory response)	0.651717	0.186
R-HSA-9660826	Purinergic signaling in leishmaniasis infection	0.651717	0.186
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	0.658466	0.181
R-HSA-437239	Recycling pathway of L1	0.658466	0.181
R-HSA-9833110	RSV-host interactions	0.661349	0.180
R-HSA-9610379	HCMV Late Events	0.664128	0.178
R-HSA-70263	Gluconeogenesis	0.665083	0.177
R-HSA-389356	Co-stimulation by CD28	0.665083	0.177
R-HSA-425410	Metal ion SLC transporters	0.665083	0.177
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.665932	0.177
R-HSA-9692914	SARS-CoV-1-host interactions	0.670464	0.174
R-HSA-157858	Gap junction trafficking and regulation	0.671573	0.173
R-HSA-877300	Interferon gamma signaling	0.671586	0.173
R-HSA-913531	Interferon Signaling	0.674478	0.171
R-HSA-211000	Gene Silencing by RNA	0.674947	0.171
R-HSA-5658442	Regulation of RAS by GAPs	0.677938	0.169
R-HSA-5655253	Signaling by FGFR2 in disease	0.677938	0.169
R-HSA-8953897	Cellular responses to stimuli	0.678248	0.169
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.679381	0.168
R-HSA-1236975	Antigen processing-Cross presentation	0.679381	0.168
R-HSA-418990	Adherens junctions interactions	0.682876	0.166
R-HSA-69002	DNA Replication Pre-Initiation	0.683765	0.165
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.683765	0.165
R-HSA-1169091	Activation of NF-kappaB in B cells	0.684180	0.165
R-HSA-912446	Meiotic recombination	0.684180	0.165
R-HSA-202403	TCR signaling	0.688100	0.162
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	0.688100	0.162
R-HSA-166166	MyD88-independent TLR4 cascade	0.688100	0.162
R-HSA-194068	Bile acid and bile salt metabolism	0.688100	0.162
R-HSA-68949	Orc1 removal from chromatin	0.690301	0.161
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	0.690301	0.161
R-HSA-9692916	SARS-CoV-1 activates/modulates innate immune responses	0.690301	0.161
R-HSA-5339562	Uptake and actions of bacterial toxins	0.690301	0.161
R-HSA-6803157	Antimicrobial peptides	0.692386	0.160
R-HSA-9639288	Amino acids regulate mTORC1	0.696303	0.157
R-HSA-5619102	SLC transporter disorders	0.700200	0.155
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.700813	0.154
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	0.702190	0.154
R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	0.702190	0.154
R-HSA-9012852	Signaling by NOTCH3	0.707963	0.150
R-HSA-418597	G alpha (z) signalling events	0.707963	0.150
R-HSA-3214815	HDACs deacetylate histones	0.707963	0.150
R-HSA-162906	HIV Infection	0.710362	0.149
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.713094	0.147
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	0.713625	0.147
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.713625	0.147
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.713782	0.146
R-HSA-5689880	Ub-specific processing proteases	0.723655	0.140
R-HSA-9764265	Regulation of CDH1 Expression and Function	0.723655	0.140
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	0.723655	0.140
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.726886	0.139
R-HSA-9033241	Peroxisomal protein import	0.729961	0.137
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.729961	0.137
R-HSA-186712	Regulation of beta-cell development	0.729961	0.137
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	0.735198	0.134
R-HSA-5362517	Signaling by Retinoic Acid	0.735198	0.134
R-HSA-8943724	Regulation of PTEN gene transcription	0.735198	0.134
R-HSA-3371556	Cellular response to heat stress	0.740115	0.131
R-HSA-9759194	Nuclear events mediated by NFE2L2	0.740115	0.131
R-HSA-1442490	Collagen degradation	0.740333	0.131
R-HSA-5653656	Vesicle-mediated transport	0.745322	0.128
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	0.745369	0.128
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.745369	0.128
R-HSA-186797	Signaling by PDGF	0.745369	0.128
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.747426	0.126
R-HSA-373755	Semaphorin interactions	0.750307	0.125
R-HSA-162909	Host Interactions of HIV factors	0.751015	0.124
R-HSA-69206	G1/S Transition	0.758062	0.120
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.769074	0.114
R-HSA-983712	Ion channel transport	0.771874	0.112
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	0.773604	0.111
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	0.773604	0.111
R-HSA-5218859	Regulated Necrosis	0.773604	0.111
R-HSA-5617833	Cilium Assembly	0.774646	0.111
R-HSA-421270	Cell-cell junction organization	0.775061	0.111
R-HSA-168898	Toll-like Receptor Cascades	0.777391	0.109
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.782304	0.107
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.782304	0.107
R-HSA-8856688	Golgi-to-ER retrograde transport	0.784553	0.105
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.786528	0.104
R-HSA-8978934	Metabolism of cofactors	0.786528	0.104
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	0.790707	0.102
R-HSA-9679506	SARS-CoV Infections	0.792829	0.101
R-HSA-4086398	Ca2+ pathway	0.794733	0.100
R-HSA-9013694	Signaling by NOTCH4	0.798717	0.098
R-HSA-1236394	Signaling by ERBB4	0.798717	0.098
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	0.802623	0.095
R-HSA-8852135	Protein ubiquitination	0.802623	0.095
R-HSA-2262752	Cellular responses to stress	0.803953	0.095
R-HSA-948021	Transport to the Golgi and subsequent modification	0.805807	0.094
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.808233	0.092
R-HSA-376176	Signaling by ROBO receptors	0.808233	0.092
R-HSA-6807070	PTEN Regulation	0.808467	0.092
R-HSA-381119	Unfolded Protein Response (UPR)	0.808467	0.092
R-HSA-9664422	FCGR3A-mediated phagocytosis	0.811284	0.091
R-HSA-9664407	Parasite infection	0.811284	0.091
R-HSA-9664417	Leishmania phagocytosis	0.811284	0.091
R-HSA-216083	Integrin cell surface interactions	0.813896	0.089
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.814065	0.089
R-HSA-1474244	Extracellular matrix organization	0.815372	0.089
R-HSA-9659379	Sensory processing of sound	0.817509	0.088
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR...	0.821052	0.086
R-HSA-977225	Amyloid fiber formation	0.824526	0.084
R-HSA-2871837	FCERI mediated NF-kB activation	0.824825	0.084
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.827934	0.082
R-HSA-453279	Mitotic G1 phase and G1/S transition	0.829993	0.081
R-HSA-5687128	MAPK6/MAPK4 signaling	0.837765	0.077
R-HSA-112316	Neuronal System	0.841820	0.075
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.844006	0.074
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	0.844684	0.073
R-HSA-8951664	Neddylation	0.849675	0.071
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.851590	0.070
R-HSA-1643685	Disease	0.855255	0.068
R-HSA-202424	Downstream TCR signaling	0.855779	0.068
R-HSA-112310	Neurotransmitter release cycle	0.855779	0.068
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.858216	0.066
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.858581	0.066
R-HSA-8986944	Transcriptional Regulation by MECP2	0.858581	0.066
R-HSA-1483257	Phospholipid metabolism	0.863619	0.064
R-HSA-9006931	Signaling by Nuclear Receptors	0.868682	0.061
R-HSA-1474290	Collagen formation	0.869257	0.061
R-HSA-72312	rRNA processing	0.869933	0.061
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.876506	0.057
R-HSA-5607764	CLEC7A (Dectin-1) signaling	0.876733	0.057
R-HSA-1296071	Potassium Channels	0.876733	0.057
R-HSA-8939211	ESR-mediated signaling	0.878319	0.056
R-HSA-8957275	Post-translational protein phosphorylation	0.881479	0.055
R-HSA-3214847	HATs acetylate histones	0.883784	0.054
R-HSA-72306	tRNA processing	0.883917	0.054
R-HSA-5621481	C-type lectin receptors (CLRs)	0.885704	0.053
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.892603	0.049
R-HSA-9678108	SARS-CoV-1 Infection	0.892603	0.049
R-HSA-5619115	Disorders of transmembrane transporters	0.893668	0.049
R-HSA-168255	Influenza Infection	0.899114	0.046
R-HSA-2559583	Cellular Senescence	0.900684	0.045
R-HSA-2672351	Stimuli-sensing channels	0.904507	0.044
R-HSA-201681	TCF dependent signaling in response to WNT	0.905257	0.043
R-HSA-2871796	FCERI mediated MAPK activation	0.911724	0.040
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.913442	0.039
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	0.916779	0.038
R-HSA-109582	Hemostasis	0.917151	0.038
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.919987	0.036
R-HSA-2029485	Role of phospholipids in phagocytosis	0.919987	0.036
R-HSA-428157	Sphingolipid metabolism	0.928816	0.032
R-HSA-6809371	Formation of the cornified envelope	0.932964	0.030
R-HSA-9658195	Leishmania infection	0.933702	0.030
R-HSA-9824443	Parasitic Infection Pathways	0.933702	0.030
R-HSA-9824446	Viral Infection Pathways	0.940518	0.027
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.941329	0.026
R-HSA-5576891	Cardiac conduction	0.943842	0.025
R-HSA-1474228	Degradation of the extracellular matrix	0.944936	0.025
R-HSA-3858494	Beta-catenin independent WNT signaling	0.950097	0.022
R-HSA-9018519	Estrogen-dependent gene expression	0.950097	0.022
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.955533	0.020
R-HSA-6798695	Neutrophil degranulation	0.957159	0.019
R-HSA-9679191	Potential therapeutics for SARS	0.962862	0.016
R-HSA-157118	Signaling by NOTCH	0.962906	0.016
R-HSA-112315	Transmission across Chemical Synapses	0.963957	0.016
R-HSA-8957322	Metabolism of steroids	0.964487	0.016
R-HSA-9609507	Protein localization	0.964994	0.015
R-HSA-9711097	Cellular response to starvation	0.968280	0.014
R-HSA-168249	Innate Immune System	0.969505	0.013
R-HSA-416476	G alpha (q) signalling events	0.975142	0.011
R-HSA-418555	G alpha (s) signalling events	0.975933	0.011
R-HSA-211945	Phase I - Functionalization of compounds	0.980372	0.009
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	0.983762	0.007
R-HSA-1630316	Glycosaminoglycan metabolism	0.984413	0.007
R-HSA-195721	Signaling by WNT	0.986039	0.006
R-HSA-1483206	Glycerophospholipid biosynthesis	0.987209	0.006
R-HSA-6805567	Keratinization	0.988182	0.005
R-HSA-597592	Post-translational protein modification	0.991503	0.004
R-HSA-446203	Asparagine N-linked glycosylation	0.992275	0.003
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.992650	0.003
R-HSA-202733	Cell surface interactions at the vascular wall	0.993602	0.003
R-HSA-5663205	Infectious disease	0.993694	0.003
R-HSA-196854	Metabolism of vitamins and cofactors	0.995567	0.002
R-HSA-9824439	Bacterial Infection Pathways	0.997251	0.001
R-HSA-425407	SLC-mediated transmembrane transport	0.997573	0.001
R-HSA-388396	GPCR downstream signalling	0.998372	0.001
R-HSA-372790	Signaling by GPCR	0.999519	0.000
R-HSA-211859	Biological oxidations	0.999753	0.000
R-HSA-8978868	Fatty acid metabolism	0.999788	0.000
R-HSA-382551	Transport of small molecules	0.999929	0.000
R-HSA-556833	Metabolism of lipids	0.999983	0.000
R-HSA-392499	Metabolism of proteins	0.999999	0.000
R-HSA-9709957	Sensory Perception	1.000000	0.000
R-HSA-1430728	Metabolism	1.000000	-0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
COT	0.898	0.311	2	0.875
CLK3	0.898	0.396	1	0.872
MOS	0.888	0.333	1	0.845
KIS	0.887	0.337	1	0.775
CDC7	0.884	0.159	1	0.834
GRK1	0.881	0.314	-2	0.821
PIM3	0.881	0.174	-3	0.875
MTOR	0.877	0.076	1	0.768
NDR2	0.876	0.120	-3	0.867
SRPK1	0.874	0.228	-3	0.795
NLK	0.874	0.198	1	0.856
CDKL1	0.873	0.178	-3	0.835
PRPK	0.873	-0.048	-1	0.871
HIPK4	0.872	0.235	1	0.832
BMPR1B	0.872	0.282	1	0.803
DSTYK	0.871	0.039	2	0.890
RAF1	0.870	-0.031	1	0.776
SKMLCK	0.870	0.147	-2	0.872
GRK7	0.870	0.256	1	0.747
IKKB	0.870	-0.030	-2	0.730
CLK2	0.870	0.322	-3	0.802
RSK2	0.870	0.156	-3	0.805
CDKL5	0.869	0.187	-3	0.823
PIM1	0.869	0.179	-3	0.835
CAMK2G	0.869	0.021	2	0.818
ATR	0.869	0.074	1	0.813
CAMK1B	0.869	0.065	-3	0.875
ERK5	0.869	0.131	1	0.834
CDK1	0.868	0.294	1	0.747
GRK5	0.868	0.050	-3	0.880
DYRK2	0.868	0.278	1	0.799
ICK	0.867	0.216	-3	0.860
GRK6	0.867	0.139	1	0.807
BMPR2	0.865	-0.084	-2	0.885
SRPK2	0.865	0.197	-3	0.731
HIPK2	0.865	0.317	1	0.727
PKN3	0.864	0.058	-3	0.854
GCN2	0.864	-0.154	2	0.813
MLK1	0.863	0.013	2	0.836
NDR1	0.863	0.045	-3	0.862
MST4	0.863	0.073	2	0.894
PDHK4	0.863	-0.264	1	0.801
RIPK3	0.863	-0.003	3	0.766
NEK6	0.863	-0.009	-2	0.872
CLK4	0.862	0.228	-3	0.812
CDK8	0.862	0.205	1	0.761
P90RSK	0.862	0.102	-3	0.809
CAMLCK	0.862	0.059	-2	0.847
CHAK2	0.862	0.041	-1	0.848
NIK	0.861	0.012	-3	0.886
TGFBR2	0.861	0.002	-2	0.834
TBK1	0.861	-0.137	1	0.658
FAM20C	0.861	0.121	2	0.614
GRK4	0.860	0.047	-2	0.857
DAPK2	0.860	0.064	-3	0.876
HIPK1	0.860	0.294	1	0.806
SRPK3	0.860	0.163	-3	0.778
IKKA	0.860	0.010	-2	0.728
P70S6KB	0.860	0.095	-3	0.825
CAMK2B	0.859	0.127	2	0.789
JNK3	0.859	0.263	1	0.753
JNK2	0.859	0.280	1	0.722
NUAK2	0.859	0.037	-3	0.869
CDK18	0.859	0.262	1	0.716
WNK1	0.859	-0.004	-2	0.877
LATS1	0.858	0.149	-3	0.876
TGFBR1	0.858	0.137	-2	0.838
PKN2	0.858	0.044	-3	0.860
RSK4	0.858	0.160	-3	0.788
PKCD	0.858	0.081	2	0.814
PRKD1	0.858	0.051	-3	0.827
PKACG	0.858	0.076	-2	0.746
PRKD2	0.858	0.096	-3	0.789
NEK7	0.857	-0.126	-3	0.825
LATS2	0.857	0.031	-5	0.766
RSK3	0.857	0.078	-3	0.801
CDK19	0.857	0.210	1	0.733
CLK1	0.857	0.222	-3	0.779
AURC	0.857	0.114	-2	0.669
ATM	0.857	0.063	1	0.765
ALK4	0.857	0.098	-2	0.858
CDK7	0.857	0.199	1	0.767
ULK2	0.857	-0.217	2	0.795
DLK	0.857	-0.006	1	0.780
MAPKAPK2	0.856	0.099	-3	0.772
IKKE	0.856	-0.166	1	0.653
CAMK2A	0.856	0.123	2	0.805
P38G	0.856	0.263	1	0.670
PRKX	0.856	0.191	-3	0.741
ACVR2B	0.855	0.165	-2	0.825
MLK3	0.855	0.054	2	0.771
CDK5	0.855	0.234	1	0.782
P38B	0.855	0.265	1	0.741
BMPR1A	0.854	0.221	1	0.783
PKACB	0.854	0.147	-2	0.685
CAMK2D	0.854	-0.002	-3	0.843
ACVR2A	0.854	0.134	-2	0.812
ERK1	0.854	0.244	1	0.728
PDHK1	0.853	-0.298	1	0.775
P38A	0.853	0.238	1	0.786
ALK2	0.853	0.152	-2	0.846
PLK1	0.853	0.029	-2	0.827
DYRK4	0.853	0.270	1	0.742
CK1E	0.853	0.207	-3	0.672
ANKRD3	0.852	-0.059	1	0.796
GSK3A	0.852	0.248	4	0.581
AMPKA1	0.852	-0.014	-3	0.869
HUNK	0.852	-0.154	2	0.795
CDK3	0.852	0.257	1	0.693
CDK13	0.852	0.186	1	0.745
CDK17	0.851	0.234	1	0.675
MSK1	0.851	0.117	-3	0.792
MAPKAPK3	0.851	0.006	-3	0.801
MSK2	0.850	0.054	-3	0.789
PKCB	0.850	0.074	2	0.764
MLK4	0.850	0.034	2	0.744
MASTL	0.850	-0.243	-2	0.802
PAK1	0.849	0.022	-2	0.786
DYRK1A	0.849	0.229	1	0.801
BCKDK	0.849	-0.180	-1	0.818
GRK2	0.849	0.060	-2	0.745
MLK2	0.848	-0.104	2	0.834
PKR	0.848	0.023	1	0.788
PKCG	0.847	0.042	2	0.764
ERK2	0.847	0.193	1	0.760
ULK1	0.847	-0.236	-3	0.791
MARK4	0.847	-0.107	4	0.790
RIPK1	0.847	-0.155	1	0.757
CDK2	0.847	0.154	1	0.800
NEK9	0.846	-0.195	2	0.849
CDK12	0.846	0.193	1	0.723
PKCA	0.846	0.052	2	0.761
PASK	0.846	0.167	-3	0.885
DYRK1B	0.846	0.234	1	0.758
CK1D	0.846	0.213	-3	0.625
TLK2	0.845	0.014	1	0.741
TTBK2	0.845	-0.156	2	0.689
AMPKA2	0.845	-0.010	-3	0.843
CDK14	0.845	0.235	1	0.747
AKT2	0.845	0.125	-3	0.738
P38D	0.845	0.256	1	0.687
DYRK3	0.845	0.227	1	0.804
WNK3	0.845	-0.277	1	0.744
CDK16	0.845	0.246	1	0.688
DNAPK	0.845	0.068	1	0.691
PRP4	0.844	0.159	-3	0.775
MYLK4	0.844	0.053	-2	0.773
CDK10	0.844	0.250	1	0.739
IRE1	0.844	-0.091	1	0.740
GSK3B	0.844	0.169	4	0.573
AURB	0.844	0.060	-2	0.663
CAMK4	0.844	-0.073	-3	0.844
AURA	0.844	0.064	-2	0.641
TSSK2	0.844	-0.066	-5	0.830
VRK2	0.842	-0.126	1	0.837
HIPK3	0.842	0.210	1	0.779
TSSK1	0.842	-0.034	-3	0.878
MNK2	0.842	0.001	-2	0.787
SGK3	0.842	0.085	-3	0.805
CK1A2	0.842	0.193	-3	0.628
PAK3	0.841	-0.053	-2	0.773
PKCZ	0.841	-0.005	2	0.800
YSK4	0.841	-0.110	1	0.699
PIM2	0.841	0.101	-3	0.783
PKG2	0.841	0.058	-2	0.681
PRKD3	0.840	0.037	-3	0.768
MEK1	0.840	-0.162	2	0.840
PKCH	0.840	-0.001	2	0.749
NIM1	0.840	-0.122	3	0.776
IRE2	0.840	-0.081	2	0.778
MNK1	0.840	0.012	-2	0.796
MEKK3	0.839	-0.013	1	0.740
GRK3	0.839	0.087	-2	0.714
PLK3	0.839	-0.065	2	0.761
NUAK1	0.839	-0.030	-3	0.819
MAK	0.839	0.300	-2	0.785
DRAK1	0.839	-0.025	1	0.748
SMG1	0.839	-0.046	1	0.768
JNK1	0.839	0.218	1	0.719
PHKG1	0.838	-0.047	-3	0.850
CDK9	0.838	0.138	1	0.751
CK2A2	0.838	0.146	1	0.706
PAK2	0.838	-0.044	-2	0.767
MST3	0.837	0.071	2	0.860
CK1G1	0.836	0.110	-3	0.669
MELK	0.836	-0.064	-3	0.820
BRAF	0.835	-0.075	-4	0.874
PKACA	0.834	0.100	-2	0.629
GAK	0.834	0.134	1	0.805
QSK	0.834	-0.062	4	0.760
CHAK1	0.834	-0.158	2	0.790
TLK1	0.834	-0.050	-2	0.860
CAMK1G	0.834	0.004	-3	0.793
DCAMKL1	0.833	0.006	-3	0.817
MEKK2	0.833	-0.045	2	0.812
TAO3	0.833	0.012	1	0.732
SMMLCK	0.832	0.025	-3	0.838
PERK	0.832	-0.133	-2	0.844
SIK	0.832	-0.047	-3	0.791
NEK2	0.831	-0.189	2	0.831
QIK	0.831	-0.169	-3	0.841
ZAK	0.831	-0.122	1	0.718
MEK5	0.830	-0.220	2	0.833
NEK5	0.830	-0.099	1	0.767
AKT1	0.830	0.091	-3	0.753
PAK6	0.830	-0.018	-2	0.686
MEKK1	0.830	-0.155	1	0.742
CK2A1	0.830	0.141	1	0.685
DAPK3	0.830	0.096	-3	0.836
BRSK1	0.829	-0.083	-3	0.821
MOK	0.829	0.250	1	0.812
MAPKAPK5	0.829	-0.085	-3	0.760
PLK4	0.828	-0.147	2	0.637
MPSK1	0.828	0.044	1	0.740
P70S6K	0.827	0.029	-3	0.746
CHK1	0.827	-0.108	-3	0.837
ERK7	0.827	0.087	2	0.578
WNK4	0.827	-0.123	-2	0.867
PINK1	0.826	-0.172	1	0.813
MARK3	0.826	-0.093	4	0.716
HRI	0.826	-0.236	-2	0.852
DAPK1	0.826	0.097	-3	0.823
PKCT	0.825	-0.018	2	0.759
GCK	0.825	0.037	1	0.734
NEK8	0.824	-0.116	2	0.835
PKCE	0.824	0.062	2	0.753
BRSK2	0.823	-0.159	-3	0.830
MARK2	0.823	-0.125	4	0.671
SGK1	0.823	0.125	-3	0.674
PLK2	0.823	0.020	-3	0.805
CDK6	0.823	0.173	1	0.726
IRAK4	0.822	-0.157	1	0.741
NEK11	0.822	-0.141	1	0.728
SNRK	0.822	-0.240	2	0.692
EEF2K	0.822	0.009	3	0.829
DCAMKL2	0.822	-0.068	-3	0.826
CAMK1D	0.822	0.027	-3	0.731
AKT3	0.821	0.112	-3	0.685
CDK4	0.820	0.174	1	0.714
LKB1	0.820	-0.087	-3	0.823
MST2	0.819	-0.060	1	0.740
PKCI	0.819	-0.031	2	0.775
PDK1	0.819	-0.085	1	0.742
TAK1	0.819	-0.026	1	0.750
MARK1	0.818	-0.148	4	0.737
TAO2	0.818	-0.123	2	0.867
ROCK2	0.817	0.097	-3	0.826
TNIK	0.817	-0.005	3	0.858
HPK1	0.817	-0.006	1	0.719
CAMKK1	0.816	-0.236	-2	0.722
CAMKK2	0.815	-0.185	-2	0.712
SSTK	0.815	-0.107	4	0.754
MRCKA	0.814	0.058	-3	0.794
MINK	0.814	-0.067	1	0.715
PHKG2	0.813	-0.113	-3	0.812
PAK5	0.813	-0.042	-2	0.628
MRCKB	0.813	0.061	-3	0.774
HGK	0.813	-0.091	3	0.854
LRRK2	0.812	-0.145	2	0.861
CK1A	0.812	0.167	-3	0.546
MAP3K15	0.812	-0.131	1	0.698
TTBK1	0.812	-0.240	2	0.606
PDHK3_TYR	0.812	0.281	4	0.895
TTK	0.812	0.080	-2	0.857
KHS2	0.812	0.039	1	0.723
PAK4	0.812	-0.026	-2	0.638
MEKK6	0.812	-0.151	1	0.728
VRK1	0.811	-0.133	2	0.847
CHK2	0.811	0.030	-3	0.685
NEK4	0.811	-0.204	1	0.716
DMPK1	0.810	0.109	-3	0.797
KHS1	0.809	-0.023	1	0.707
BUB1	0.809	0.057	-5	0.811
PDHK4_TYR	0.809	0.251	2	0.890
PKN1	0.808	-0.015	-3	0.757
MST1	0.808	-0.119	1	0.716
IRAK1	0.808	-0.355	-1	0.762
MAP2K6_TYR	0.807	0.216	-1	0.906
SBK	0.807	0.085	-3	0.624
CAMK1A	0.806	0.022	-3	0.698
OSR1	0.806	-0.003	2	0.815
NEK1	0.806	-0.190	1	0.729
LOK	0.806	-0.120	-2	0.737
SLK	0.806	-0.110	-2	0.690
ALPHAK3	0.806	0.061	-1	0.809
BMPR2_TYR	0.805	0.208	-1	0.924
MAP2K4_TYR	0.804	0.124	-1	0.892
PBK	0.804	-0.025	1	0.723
PDHK1_TYR	0.804	0.173	-1	0.918
STK33	0.804	-0.189	2	0.610
HASPIN	0.803	0.027	-1	0.714
ROCK1	0.802	0.062	-3	0.792
TESK1_TYR	0.801	0.012	3	0.877
CRIK	0.800	0.086	-3	0.749
YSK1	0.800	-0.137	2	0.832
YANK3	0.798	-0.035	2	0.387
PKMYT1_TYR	0.797	-0.031	3	0.854
MAP2K7_TYR	0.795	-0.155	2	0.866
PKG1	0.795	-0.008	-2	0.594
RIPK2	0.794	-0.350	1	0.663
PINK1_TYR	0.793	-0.120	1	0.790
MEK2	0.793	-0.396	2	0.816
EPHA6	0.792	0.073	-1	0.910
LIMK2_TYR	0.792	-0.009	-3	0.871
TXK	0.792	0.167	1	0.806
MYO3B	0.792	-0.076	2	0.850
EPHB4	0.791	0.045	-1	0.870
MYO3A	0.788	-0.106	1	0.715
ASK1	0.788	-0.210	1	0.687
BIKE	0.788	-0.031	1	0.697
NEK3	0.785	-0.269	1	0.687
RET	0.785	-0.146	1	0.742
FGR	0.785	-0.010	1	0.797
CK1G3	0.785	0.119	-3	0.503
ABL2	0.784	-0.000	-1	0.825
BLK	0.784	0.136	-1	0.868
YES1	0.784	-0.021	-1	0.843
EPHA4	0.783	0.006	2	0.763
INSRR	0.783	-0.026	3	0.734
LCK	0.782	0.092	-1	0.860
LIMK1_TYR	0.782	-0.240	2	0.864
CSF1R	0.781	-0.104	3	0.779
MST1R	0.781	-0.173	3	0.797
TAO1	0.781	-0.181	1	0.648
JAK3	0.780	-0.067	1	0.729
FYN	0.780	0.133	-1	0.847
FER	0.780	-0.101	1	0.831
TYRO3	0.780	-0.185	3	0.781
ABL1	0.779	-0.039	-1	0.812
ROS1	0.779	-0.164	3	0.756
SRMS	0.779	-0.038	1	0.812
DDR1	0.779	-0.195	4	0.799
HCK	0.778	-0.029	-1	0.851
KDR	0.778	-0.042	3	0.750
EPHB1	0.778	-0.048	1	0.804
ITK	0.777	-0.036	-1	0.817
TYK2	0.777	-0.282	1	0.734
EPHB2	0.777	-0.008	-1	0.852
TNK2	0.777	-0.066	3	0.757
FLT1	0.777	0.017	-1	0.885
JAK2	0.776	-0.216	1	0.735
CK1G2	0.776	0.137	-3	0.592
KIT	0.776	-0.101	3	0.783
FGFR2	0.776	-0.127	3	0.791
MET	0.775	-0.024	3	0.769
EPHB3	0.775	-0.047	-1	0.857
STLK3	0.774	-0.253	1	0.674
SYK	0.774	0.184	-1	0.853
PTK2	0.774	0.154	-1	0.873
BMX	0.773	-0.020	-1	0.745
EPHA7	0.770	-0.038	2	0.764
MERTK	0.770	-0.107	3	0.765
PDGFRB	0.770	-0.218	3	0.786
AAK1	0.769	0.007	1	0.607
TEC	0.768	-0.085	-1	0.737
FLT3	0.768	-0.210	3	0.778
FGFR3	0.767	-0.106	3	0.763
TNNI3K_TYR	0.767	-0.098	1	0.762
TEK	0.767	-0.195	3	0.725
TNK1	0.767	-0.168	3	0.768
DDR2	0.766	-0.024	3	0.729
EPHA3	0.766	-0.120	2	0.739
ERBB2	0.766	-0.133	1	0.712
EPHA5	0.766	-0.021	2	0.747
YANK2	0.766	-0.061	2	0.401
NEK10_TYR	0.766	-0.199	1	0.605
FGFR1	0.765	-0.214	3	0.751
WEE1_TYR	0.765	-0.126	-1	0.754
AXL	0.765	-0.201	3	0.764
EPHA8	0.765	-0.018	-1	0.864
JAK1	0.765	-0.152	1	0.674
SRC	0.764	-0.015	-1	0.828
NTRK1	0.764	-0.213	-1	0.834
LYN	0.763	-0.065	3	0.718
FRK	0.763	-0.091	-1	0.861
PTK6	0.762	-0.230	-1	0.732
FLT4	0.762	-0.174	3	0.757
EGFR	0.762	-0.057	1	0.630
BTK	0.761	-0.260	-1	0.761
LTK	0.761	-0.198	3	0.727
PTK2B	0.761	-0.083	-1	0.773
MATK	0.760	-0.122	-1	0.757
ALK	0.760	-0.217	3	0.693
INSR	0.759	-0.188	3	0.719
PDGFRA	0.759	-0.330	3	0.784
EPHA1	0.758	-0.167	3	0.745
NTRK3	0.758	-0.160	-1	0.791
ERBB4	0.756	0.011	1	0.670
FGFR4	0.756	-0.096	-1	0.796
NTRK2	0.755	-0.274	3	0.738
EPHA2	0.754	-0.038	-1	0.831
CSK	0.753	-0.180	2	0.764
ZAP70	0.749	0.065	-1	0.772
IGF1R	0.748	-0.143	3	0.659
MUSK	0.739	-0.218	1	0.612
FES	0.731	-0.172	-1	0.716