Motif 453 (n=148)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1487 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O14639 | ABLIM1 | S450 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14646 | CHD1 | S1096 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14715 | RGPD8 | S1486 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14974 | PPP1R12A | S908 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15211 | RGL2 | S617 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O60508 | CDC40 | S43 | ochoa | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}. |
| O60941 | DTNB | S550 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75381 | PEX14 | S247 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75925 | PIAS1 | S483 | ochoa | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O95359 | TACC2 | S2569 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95835 | LATS1 | S216 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P04049 | RAF1 | S619 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P0DJD0 | RGPD1 | S1471 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1479 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P15408 | FOSL2 | S230 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P35568 | IRS1 | S268 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P36897 | TGFBR1 | S187 | psp | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P46100 | ATRX | S48 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P47736 | RAP1GAP | S456 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P48681 | NES | S471 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49736 | MCM2 | S27 | ochoa|psp | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49792 | RANBP2 | S2462 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S1383 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P49815 | TSC2 | S1464 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50548 | ERF | S185 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P50851 | LRBA | T1079 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51116 | FXR2 | S637 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51957 | NEK4 | S639 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P53396 | ACLY | S459 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P54725 | RAD23A | S138 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| Q12802 | AKAP13 | S2718 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13163 | MAP2K5 | S144 | ochoa | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:Q62862, ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}. |
| Q13459 | MYO9B | S1276 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13501 | SQSTM1 | S361 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13523 | PRP4K | S578 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13586 | STIM1 | S616 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14004 | CDK13 | S395 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14432 | PDE3A | S490 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14999 | CUL7 | S1124 | ochoa | Cullin-7 (CUL-7) | Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. {ECO:0000269|PubMed:12481031, ECO:0000269|PubMed:12904573, ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:21737058, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:35982156}. |
| Q15596 | NCOA2 | S675 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16643 | DBN1 | S337 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q4AC94 | C2CD3 | S2146 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q4L180 | FILIP1L | S1047 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
| Q52LW3 | ARHGAP29 | S573 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5T200 | ZC3H13 | S333 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5TH69 | ARFGEF3 | S2095 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VT06 | CEP350 | S707 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q6AWC2 | WWC2 | S1020 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6KC79 | NIPBL | S148 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6KC79 | NIPBL | S299 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P0Q8 | MAST2 | S249 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P4F7 | ARHGAP11A | S335 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6UUV9 | CRTC1 | S167 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6ZNL6 | FGD5 | S716 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZTU2 | EP400P1 | S170 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q7KZI7 | MARK2 | S593 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z2K8 | GPRIN1 | S90 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S1428 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3J3 | RGPD4 | S1487 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6B7 | SRGAP1 | S1027 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86VP3 | PACS2 | S702 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86YW5 | TREML1 | S217 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IV50 | LYSMD2 | S29 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
| Q8IWS0 | PHF6 | S199 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IX03 | WWC1 | S945 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IY57 | YAF2 | S151 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8IYB3 | SRRM1 | S653 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N3F8 | MICALL1 | S553 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N612 | FHIP1B | S482 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8NCD3 | HJURP | S555 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NDI1 | EHBP1 | S664 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NEY1 | NAV1 | S1182 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NI08 | NCOA7 | S179 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8WUA7 | TBC1D22A | S165 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q8WWI1 | LMO7 | S1010 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWQ0 | PHIP | S1471 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WX93 | PALLD | S1116 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q92625 | ANKS1A | S643 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q969V6 | MRTFA | S151 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96HC4 | PDLIM5 | S377 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96L91 | EP400 | S181 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q99569 | PKP4 | S151 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99569 | PKP4 | S1153 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99666 | RGPD5 | S1486 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99700 | ATXN2 | S528 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99759 | MAP3K3 | S145 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9BQ89 | FAM110A | S244 | ochoa | Protein FAM110A | None |
| Q9BTC0 | DIDO1 | S1034 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BXF6 | RAB11FIP5 | S391 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY77 | POLDIP3 | S383 | ochoa|psp | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9C0B5 | ZDHHC5 | S360 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0B5 | ZDHHC5 | S423 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S1616 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H1K0 | RBSN | S230 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H4A3 | WNK1 | S183 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H4A3 | WNK1 | S2027 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H6T3 | RPAP3 | S521 | ochoa | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H7U1 | CCSER2 | S221 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9HCD6 | TANC2 | S1720 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NRL2 | BAZ1A | S1296 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NV70 | EXOC1 | S487 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9NYV4 | CDK12 | S251 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NYV4 | CDK12 | S291 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NYV4 | CDK12 | S318 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZ72 | STMN3 | S68 | ochoa|psp | Stathmin-3 (SCG10-like protein) | Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}. |
| Q9NZB2 | FAM120A | S457 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZJ0 | DTL | S441 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P1Y5 | CAMSAP3 | S380 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P219 | CCDC88C | S1599 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P227 | ARHGAP23 | S598 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UHB6 | LIMA1 | S369 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | S514 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UIG0 | BAZ1B | S345 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9ULJ3 | ZBTB21 | S343 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULP9 | TBC1D24 | S468 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}. |
| Q9UQ35 | SRRM2 | S778 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S834 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S871 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S890 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S908 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S910 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S950 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S952 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S968 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S988 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1008 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1048 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | Y1049 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1079 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1214 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1419 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1439 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1458 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1478 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1497 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1517 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1537 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1557 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1577 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1616 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2F5 | ICE1 | S939 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2L6 | FRMD4B | S692 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y2U5 | MAP3K2 | S309 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y4H2 | IRS2 | S592 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H4 | GPSM3 | S54 | ochoa | G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18) | Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. {ECO:0000269|PubMed:14656218, ECO:0000269|PubMed:15096500}. |
| Q9Y4J8 | DTNA | S579 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q6P158 | DHX57 | S70 | Sugiyama | Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) | Probable ATP-binding RNA helicase. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-74713 | IRS activation | 0.001458 | 2.836 |
| R-HSA-112412 | SOS-mediated signalling | 0.002930 | 2.533 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.004051 | 2.392 |
| R-HSA-198203 | PI3K/AKT activation | 0.004877 | 2.312 |
| R-HSA-176974 | Unwinding of DNA | 0.004177 | 2.379 |
| R-HSA-74749 | Signal attenuation | 0.004877 | 2.312 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003528 | 2.453 |
| R-HSA-2586552 | Signaling by Leptin | 0.004877 | 2.312 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.005849 | 2.233 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.005627 | 2.250 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.015651 | 1.805 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.015651 | 1.805 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.015651 | 1.805 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.015651 | 1.805 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.015651 | 1.805 |
| R-HSA-72187 | mRNA 3'-end processing | 0.012239 | 1.912 |
| R-HSA-2028269 | Signaling by Hippo | 0.013337 | 1.875 |
| R-HSA-392517 | Rap1 signalling | 0.015711 | 1.804 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.015037 | 1.823 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.015037 | 1.823 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.017692 | 1.752 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.022363 | 1.650 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.025295 | 1.597 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.031058 | 1.508 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.031058 | 1.508 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.033259 | 1.478 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.031793 | 1.498 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.031058 | 1.508 |
| R-HSA-198765 | Signalling to ERK5 | 0.031058 | 1.508 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.038672 | 1.413 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.034956 | 1.456 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.038446 | 1.415 |
| R-HSA-69190 | DNA strand elongation | 0.036685 | 1.436 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.033259 | 1.478 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.026817 | 1.572 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.033601 | 1.474 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.038446 | 1.415 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.046227 | 1.335 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.046227 | 1.335 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.053722 | 1.270 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.053722 | 1.270 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.061159 | 1.214 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.068538 | 1.164 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.075860 | 1.120 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.075860 | 1.120 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.083125 | 1.080 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.083125 | 1.080 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.097484 | 1.011 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.118606 | 0.926 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.139237 | 0.856 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.139237 | 0.856 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.241442 | 0.617 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.247414 | 0.607 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.253340 | 0.596 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.253340 | 0.596 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.265052 | 0.577 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.265052 | 0.577 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.270840 | 0.567 |
| R-HSA-390522 | Striated Muscle Contraction | 0.270840 | 0.567 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.270840 | 0.567 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.282280 | 0.549 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.304628 | 0.516 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.310107 | 0.508 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.310107 | 0.508 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.088903 | 1.051 |
| R-HSA-72172 | mRNA Splicing | 0.102044 | 0.991 |
| R-HSA-5673000 | RAF activation | 0.276582 | 0.558 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.053631 | 1.271 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.103577 | 0.985 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.068538 | 1.164 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.315542 | 0.501 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.164466 | 0.784 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.061159 | 1.214 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.075860 | 1.120 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.090332 | 1.044 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.111620 | 0.952 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.125537 | 0.901 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.146007 | 0.836 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.293542 | 0.532 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.198282 | 0.703 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.247368 | 0.607 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.139237 | 0.856 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.118606 | 0.926 |
| R-HSA-112399 | IRS-mediated signalling | 0.093757 | 1.028 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.111118 | 0.954 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.075860 | 1.120 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.159389 | 0.798 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.111118 | 0.954 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.259219 | 0.586 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.270840 | 0.567 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.198300 | 0.703 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.113663 | 0.944 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.061159 | 1.214 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.210869 | 0.676 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.227882 | 0.642 |
| R-HSA-8951664 | Neddylation | 0.123992 | 0.907 |
| R-HSA-9664873 | Pexophagy | 0.097484 | 1.011 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.239672 | 0.620 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.195429 | 0.709 |
| R-HSA-9842663 | Signaling by LTK | 0.118606 | 0.926 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.235746 | 0.628 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.147986 | 0.830 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.192582 | 0.715 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.132414 | 0.878 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.247414 | 0.607 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.276582 | 0.558 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.210869 | 0.676 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.111620 | 0.952 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.118606 | 0.926 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.081899 | 1.087 |
| R-HSA-429947 | Deadenylation of mRNA | 0.210869 | 0.676 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.217080 | 0.663 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.241442 | 0.617 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.310107 | 0.508 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.310107 | 0.508 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.315542 | 0.501 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.090332 | 1.044 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.270840 | 0.567 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.282280 | 0.549 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.282280 | 0.549 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.051632 | 1.287 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.179073 | 0.747 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.265052 | 0.577 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.134535 | 0.871 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.299107 | 0.524 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.235423 | 0.628 |
| R-HSA-73886 | Chromosome Maintenance | 0.288128 | 0.540 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.215497 | 0.667 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.134535 | 0.871 |
| R-HSA-5689877 | Josephin domain DUBs | 0.097484 | 1.011 |
| R-HSA-109704 | PI3K Cascade | 0.077297 | 1.112 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.293542 | 0.532 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.304628 | 0.516 |
| R-HSA-69239 | Synthesis of DNA | 0.241553 | 0.617 |
| R-HSA-8854214 | TBC/RABGAPs | 0.061893 | 1.208 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.293942 | 0.532 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.281070 | 0.551 |
| R-HSA-3214847 | HATs acetylate histones | 0.215497 | 0.667 |
| R-HSA-69206 | G1/S Transition | 0.302652 | 0.519 |
| R-HSA-5205647 | Mitophagy | 0.276582 | 0.558 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.075860 | 1.120 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.139882 | 0.854 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.265052 | 0.577 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.118606 | 0.926 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.247414 | 0.607 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.191941 | 0.717 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.317126 | 0.499 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.087247 | 1.059 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.304628 | 0.516 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.315542 | 0.501 |
| R-HSA-1640170 | Cell Cycle | 0.123044 | 0.910 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.139237 | 0.856 |
| R-HSA-8853659 | RET signaling | 0.045803 | 1.339 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.229356 | 0.639 |
| R-HSA-9694548 | Maturation of spike protein | 0.315542 | 0.501 |
| R-HSA-69481 | G2/M Checkpoints | 0.308448 | 0.511 |
| R-HSA-9707616 | Heme signaling | 0.106074 | 0.974 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.062561 | 1.204 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.198300 | 0.703 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.182454 | 0.739 |
| R-HSA-162582 | Signal Transduction | 0.049328 | 1.307 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.156183 | 0.806 |
| R-HSA-264876 | Insulin processing | 0.229356 | 0.639 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.276486 | 0.558 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.204609 | 0.689 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.223242 | 0.651 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.276582 | 0.558 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.276486 | 0.558 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.088955 | 1.051 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.104441 | 0.981 |
| R-HSA-201556 | Signaling by ALK | 0.304628 | 0.516 |
| R-HSA-8939211 | ESR-mediated signaling | 0.146320 | 0.835 |
| R-HSA-166520 | Signaling by NTRKs | 0.144178 | 0.841 |
| R-HSA-69275 | G2/M Transition | 0.220343 | 0.657 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.224462 | 0.649 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.244460 | 0.612 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.186904 | 0.728 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.288128 | 0.540 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.172825 | 0.762 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.189740 | 0.722 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.221267 | 0.655 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.320935 | 0.494 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.320935 | 0.494 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.320935 | 0.494 |
| R-HSA-9909396 | Circadian clock | 0.325779 | 0.487 |
| R-HSA-165159 | MTOR signalling | 0.326286 | 0.486 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.328847 | 0.483 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.331595 | 0.479 |
| R-HSA-373752 | Netrin-1 signaling | 0.336863 | 0.473 |
| R-HSA-163685 | Integration of energy metabolism | 0.340137 | 0.468 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.342089 | 0.466 |
| R-HSA-774815 | Nucleosome assembly | 0.342089 | 0.466 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.342089 | 0.466 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.347275 | 0.459 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.347275 | 0.459 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.347275 | 0.459 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.347275 | 0.459 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.347275 | 0.459 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.347275 | 0.459 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.348708 | 0.458 |
| R-HSA-73894 | DNA Repair | 0.352068 | 0.453 |
| R-HSA-1632852 | Macroautophagy | 0.354402 | 0.451 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.357432 | 0.447 |
| R-HSA-73893 | DNA Damage Bypass | 0.362589 | 0.441 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.371377 | 0.430 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.375723 | 0.425 |
| R-HSA-69242 | S Phase | 0.376997 | 0.424 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.377547 | 0.423 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.377547 | 0.423 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.377547 | 0.423 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.382455 | 0.417 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.382455 | 0.417 |
| R-HSA-1221632 | Meiotic synapsis | 0.382455 | 0.417 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.382597 | 0.417 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.385389 | 0.414 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.388175 | 0.411 |
| R-HSA-69306 | DNA Replication | 0.390957 | 0.408 |
| R-HSA-73887 | Death Receptor Signaling | 0.393732 | 0.405 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.396951 | 0.401 |
| R-HSA-5578775 | Ion homeostasis | 0.396951 | 0.401 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.397005 | 0.401 |
| R-HSA-9612973 | Autophagy | 0.399266 | 0.399 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.401707 | 0.396 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.401707 | 0.396 |
| R-HSA-9610379 | HCMV Late Events | 0.402025 | 0.396 |
| R-HSA-877300 | Interferon gamma signaling | 0.407524 | 0.390 |
| R-HSA-9033241 | Peroxisomal protein import | 0.411108 | 0.386 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.411108 | 0.386 |
| R-HSA-191859 | snRNP Assembly | 0.411108 | 0.386 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.411108 | 0.386 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.411108 | 0.386 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.420363 | 0.376 |
| R-HSA-211976 | Endogenous sterols | 0.420363 | 0.376 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.424936 | 0.372 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.424936 | 0.372 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.429474 | 0.367 |
| R-HSA-2262752 | Cellular responses to stress | 0.435422 | 0.361 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.438442 | 0.358 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.447270 | 0.349 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.447270 | 0.349 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.453237 | 0.344 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.453388 | 0.344 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.460256 | 0.337 |
| R-HSA-422475 | Axon guidance | 0.462605 | 0.335 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.464516 | 0.333 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.464516 | 0.333 |
| R-HSA-2559583 | Cellular Senescence | 0.466304 | 0.331 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.468744 | 0.329 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.472938 | 0.325 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.477099 | 0.321 |
| R-HSA-8852135 | Protein ubiquitination | 0.481228 | 0.318 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.481228 | 0.318 |
| R-HSA-5689603 | UCH proteinases | 0.485325 | 0.314 |
| R-HSA-983712 | Ion channel transport | 0.489357 | 0.310 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.489389 | 0.310 |
| R-HSA-5617833 | Cilium Assembly | 0.491880 | 0.308 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.493422 | 0.307 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.497423 | 0.303 |
| R-HSA-9609690 | HCMV Early Events | 0.506856 | 0.295 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.513115 | 0.290 |
| R-HSA-8953854 | Metabolism of RNA | 0.515734 | 0.288 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.516962 | 0.287 |
| R-HSA-9675108 | Nervous system development | 0.518294 | 0.285 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.520778 | 0.283 |
| R-HSA-1500620 | Meiosis | 0.520778 | 0.283 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.520778 | 0.283 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.523966 | 0.281 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.524565 | 0.280 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.524565 | 0.280 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.528322 | 0.277 |
| R-HSA-9663891 | Selective autophagy | 0.535747 | 0.271 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.535828 | 0.271 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.543057 | 0.265 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.545833 | 0.263 |
| R-HSA-397014 | Muscle contraction | 0.547716 | 0.261 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.550045 | 0.260 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.553808 | 0.257 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.557335 | 0.254 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.571171 | 0.243 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.574562 | 0.241 |
| R-HSA-157579 | Telomere Maintenance | 0.574562 | 0.241 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.575686 | 0.240 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.581265 | 0.236 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.584577 | 0.233 |
| R-HSA-70171 | Glycolysis | 0.584577 | 0.233 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.591123 | 0.228 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.597023 | 0.224 |
| R-HSA-418346 | Platelet homeostasis | 0.607045 | 0.217 |
| R-HSA-157118 | Signaling by NOTCH | 0.609759 | 0.215 |
| R-HSA-211000 | Gene Silencing by RNA | 0.610155 | 0.215 |
| R-HSA-74160 | Gene expression (Transcription) | 0.614469 | 0.211 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.616301 | 0.210 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.619338 | 0.208 |
| R-HSA-913531 | Interferon Signaling | 0.620380 | 0.207 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.625341 | 0.204 |
| R-HSA-4839726 | Chromatin organization | 0.628292 | 0.202 |
| R-HSA-9609646 | HCMV Infection | 0.630309 | 0.200 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.637066 | 0.196 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.637066 | 0.196 |
| R-HSA-5688426 | Deubiquitination | 0.640267 | 0.194 |
| R-HSA-70326 | Glucose metabolism | 0.645620 | 0.190 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.645620 | 0.190 |
| R-HSA-68875 | Mitotic Prophase | 0.653975 | 0.184 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.656716 | 0.183 |
| R-HSA-3371556 | Cellular response to heat stress | 0.656716 | 0.183 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.662133 | 0.179 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.664810 | 0.177 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.664810 | 0.177 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.670101 | 0.174 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.670101 | 0.174 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.670101 | 0.174 |
| R-HSA-114608 | Platelet degranulation | 0.675309 | 0.170 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.676205 | 0.170 |
| R-HSA-1474165 | Reproduction | 0.685482 | 0.164 |
| R-HSA-9843745 | Adipogenesis | 0.687975 | 0.162 |
| R-HSA-5576891 | Cardiac conduction | 0.687975 | 0.162 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.690449 | 0.161 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.692903 | 0.159 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.711226 | 0.148 |
| R-HSA-9664407 | Parasite infection | 0.711855 | 0.148 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.711855 | 0.148 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.711855 | 0.148 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.714141 | 0.146 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.718659 | 0.143 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.718659 | 0.143 |
| R-HSA-9609507 | Protein localization | 0.742270 | 0.129 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.742270 | 0.129 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.744316 | 0.128 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.744316 | 0.128 |
| R-HSA-1989781 | PPARA activates gene expression | 0.746347 | 0.127 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.746347 | 0.127 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.750359 | 0.125 |
| R-HSA-162587 | HIV Life Cycle | 0.750359 | 0.125 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.752342 | 0.124 |
| R-HSA-449147 | Signaling by Interleukins | 0.753815 | 0.123 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.755585 | 0.122 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.756260 | 0.121 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.763914 | 0.117 |
| R-HSA-109582 | Hemostasis | 0.766042 | 0.116 |
| R-HSA-1474244 | Extracellular matrix organization | 0.766836 | 0.115 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.767506 | 0.115 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.769497 | 0.114 |
| R-HSA-5619102 | SLC transporter disorders | 0.769497 | 0.114 |
| R-HSA-72306 | tRNA processing | 0.776738 | 0.110 |
| R-HSA-418555 | G alpha (s) signalling events | 0.778512 | 0.109 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.778512 | 0.109 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.782020 | 0.107 |
| R-HSA-597592 | Post-translational protein modification | 0.783606 | 0.106 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.783753 | 0.106 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.790529 | 0.102 |
| R-HSA-168255 | Influenza Infection | 0.792215 | 0.101 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.798748 | 0.098 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.811208 | 0.091 |
| R-HSA-68877 | Mitotic Prometaphase | 0.814201 | 0.089 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.828476 | 0.082 |
| R-HSA-68886 | M Phase | 0.829590 | 0.081 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.830633 | 0.081 |
| R-HSA-6805567 | Keratinization | 0.833877 | 0.079 |
| R-HSA-68882 | Mitotic Anaphase | 0.846651 | 0.072 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.847874 | 0.072 |
| R-HSA-1280218 | Adaptive Immune System | 0.852922 | 0.069 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.858451 | 0.066 |
| R-HSA-162906 | HIV Infection | 0.859580 | 0.066 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.860700 | 0.065 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.861812 | 0.065 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.880377 | 0.055 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.880382 | 0.055 |
| R-HSA-6798695 | Neutrophil degranulation | 0.893620 | 0.049 |
| R-HSA-199991 | Membrane Trafficking | 0.901643 | 0.045 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.906731 | 0.043 |
| R-HSA-9658195 | Leishmania infection | 0.908952 | 0.041 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.908952 | 0.041 |
| R-HSA-1483257 | Phospholipid metabolism | 0.918646 | 0.037 |
| R-HSA-195721 | Signaling by WNT | 0.920586 | 0.036 |
| R-HSA-8957322 | Metabolism of steroids | 0.935587 | 0.029 |
| R-HSA-168256 | Immune System | 0.941941 | 0.026 |
| R-HSA-9679506 | SARS-CoV Infections | 0.944064 | 0.025 |
| R-HSA-388396 | GPCR downstream signalling | 0.952957 | 0.021 |
| R-HSA-1266738 | Developmental Biology | 0.955783 | 0.020 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.961750 | 0.017 |
| R-HSA-418594 | G alpha (i) signalling events | 0.967326 | 0.014 |
| R-HSA-8978868 | Fatty acid metabolism | 0.967326 | 0.014 |
| R-HSA-212436 | Generic Transcription Pathway | 0.969915 | 0.013 |
| R-HSA-372790 | Signaling by GPCR | 0.971762 | 0.012 |
| R-HSA-392499 | Metabolism of proteins | 0.977029 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.977867 | 0.010 |
| R-HSA-112316 | Neuronal System | 0.980087 | 0.009 |
| R-HSA-168249 | Innate Immune System | 0.984303 | 0.007 |
| R-HSA-211859 | Biological oxidations | 0.987279 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 0.995177 | 0.002 |
| R-HSA-1643685 | Disease | 0.996966 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.997303 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.999564 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999627 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK2 |
0.806 | 0.430 | -3 | 0.782 |
CLK3 |
0.803 | 0.389 | 1 | 0.839 |
DYRK4 |
0.791 | 0.336 | 1 | 0.758 |
DYRK2 |
0.785 | 0.287 | 1 | 0.821 |
HIPK4 |
0.781 | 0.220 | 1 | 0.866 |
SRPK1 |
0.781 | 0.230 | -3 | 0.805 |
AURC |
0.781 | 0.263 | -2 | 0.813 |
CLK4 |
0.781 | 0.329 | -3 | 0.797 |
RSK2 |
0.780 | 0.248 | -3 | 0.814 |
HIPK2 |
0.779 | 0.244 | 1 | 0.767 |
PIM3 |
0.779 | 0.229 | -3 | 0.844 |
PRKX |
0.778 | 0.275 | -3 | 0.750 |
GSK3A |
0.777 | 0.383 | 4 | 0.774 |
NDR2 |
0.776 | 0.174 | -3 | 0.841 |
SKMLCK |
0.776 | 0.302 | -2 | 0.909 |
MSK1 |
0.774 | 0.298 | -3 | 0.799 |
PKACB |
0.774 | 0.261 | -2 | 0.812 |
RSK4 |
0.773 | 0.244 | -3 | 0.811 |
CAMK2A |
0.772 | 0.251 | 2 | 0.465 |
COT |
0.772 | 0.165 | 2 | 0.456 |
PIM1 |
0.772 | 0.222 | -3 | 0.820 |
GRK1 |
0.772 | 0.200 | -2 | 0.776 |
DYRK3 |
0.770 | 0.295 | 1 | 0.834 |
CLK1 |
0.769 | 0.281 | -3 | 0.773 |
HIPK1 |
0.768 | 0.238 | 1 | 0.834 |
ICK |
0.768 | 0.233 | -3 | 0.858 |
P90RSK |
0.768 | 0.203 | -3 | 0.819 |
MTOR |
0.767 | 0.184 | 1 | 0.748 |
PKACG |
0.766 | 0.207 | -2 | 0.830 |
GSK3B |
0.766 | 0.355 | 4 | 0.771 |
CAMK2B |
0.765 | 0.193 | 2 | 0.431 |
SRPK2 |
0.765 | 0.178 | -3 | 0.758 |
PRKD2 |
0.765 | 0.161 | -3 | 0.804 |
CDKL1 |
0.764 | 0.180 | -3 | 0.838 |
NDR1 |
0.764 | 0.142 | -3 | 0.831 |
CDKL5 |
0.764 | 0.156 | -3 | 0.840 |
PAK1 |
0.763 | 0.205 | -2 | 0.886 |
MOS |
0.763 | 0.141 | 1 | 0.796 |
MSK2 |
0.763 | 0.223 | -3 | 0.804 |
CAMK1B |
0.762 | 0.193 | -3 | 0.832 |
MAPKAPK2 |
0.761 | 0.164 | -3 | 0.787 |
KIS |
0.761 | 0.120 | 1 | 0.780 |
CDC7 |
0.761 | 0.054 | 1 | 0.733 |
MAK |
0.760 | 0.271 | -2 | 0.841 |
P70S6KB |
0.760 | 0.169 | -3 | 0.811 |
AURB |
0.760 | 0.218 | -2 | 0.811 |
RSK3 |
0.760 | 0.166 | -3 | 0.798 |
NLK |
0.757 | 0.115 | 1 | 0.843 |
PRKD1 |
0.757 | 0.104 | -3 | 0.829 |
DYRK1B |
0.757 | 0.216 | 1 | 0.776 |
MNK1 |
0.756 | 0.188 | -2 | 0.862 |
LATS2 |
0.756 | 0.093 | -5 | 0.693 |
MNK2 |
0.756 | 0.179 | -2 | 0.867 |
JNK2 |
0.756 | 0.206 | 1 | 0.721 |
IKKB |
0.756 | 0.071 | -2 | 0.674 |
CAMK2G |
0.756 | 0.080 | 2 | 0.420 |
AURA |
0.755 | 0.214 | -2 | 0.804 |
DYRK1A |
0.755 | 0.201 | 1 | 0.808 |
CAMLCK |
0.755 | 0.210 | -2 | 0.888 |
CDK1 |
0.755 | 0.160 | 1 | 0.749 |
GRK7 |
0.754 | 0.169 | 1 | 0.700 |
ERK5 |
0.754 | 0.081 | 1 | 0.830 |
PASK |
0.754 | 0.318 | -3 | 0.865 |
CDK18 |
0.754 | 0.150 | 1 | 0.740 |
SRPK3 |
0.754 | 0.147 | -3 | 0.784 |
AKT2 |
0.754 | 0.205 | -3 | 0.758 |
CAMK2D |
0.753 | 0.124 | -3 | 0.825 |
MYLK4 |
0.753 | 0.230 | -2 | 0.866 |
CDK10 |
0.753 | 0.189 | 1 | 0.758 |
NUAK2 |
0.753 | 0.110 | -3 | 0.839 |
WNK1 |
0.752 | 0.107 | -2 | 0.869 |
GRK6 |
0.752 | 0.157 | 1 | 0.723 |
FAM20C |
0.752 | 0.025 | 2 | 0.296 |
GRK5 |
0.752 | 0.084 | -3 | 0.759 |
DAPK2 |
0.751 | 0.192 | -3 | 0.838 |
JNK3 |
0.751 | 0.187 | 1 | 0.754 |
PKACA |
0.751 | 0.218 | -2 | 0.768 |
RIPK3 |
0.750 | 0.095 | 3 | 0.686 |
ATR |
0.750 | 0.042 | 1 | 0.752 |
PAK6 |
0.750 | 0.153 | -2 | 0.812 |
MAPKAPK3 |
0.750 | 0.115 | -3 | 0.801 |
PKN2 |
0.750 | 0.105 | -3 | 0.812 |
LATS1 |
0.750 | 0.201 | -3 | 0.849 |
PKG2 |
0.750 | 0.170 | -2 | 0.792 |
PAK3 |
0.749 | 0.141 | -2 | 0.866 |
CDK14 |
0.749 | 0.171 | 1 | 0.768 |
HIPK3 |
0.748 | 0.186 | 1 | 0.804 |
PKN3 |
0.748 | 0.067 | -3 | 0.832 |
PKCD |
0.748 | 0.087 | 2 | 0.343 |
RAF1 |
0.748 | 0.074 | 1 | 0.731 |
P38B |
0.748 | 0.169 | 1 | 0.751 |
ERK1 |
0.748 | 0.145 | 1 | 0.741 |
PRPK |
0.748 | -0.060 | -1 | 0.703 |
HUNK |
0.748 | 0.078 | 2 | 0.453 |
PKCG |
0.747 | 0.087 | 2 | 0.347 |
CHAK2 |
0.747 | 0.035 | -1 | 0.781 |
PAK2 |
0.747 | 0.154 | -2 | 0.872 |
CDK7 |
0.747 | 0.119 | 1 | 0.774 |
PKCB |
0.746 | 0.074 | 2 | 0.329 |
CDK8 |
0.746 | 0.103 | 1 | 0.752 |
NIK |
0.745 | 0.101 | -3 | 0.818 |
PDHK4 |
0.745 | -0.043 | 1 | 0.767 |
P38A |
0.745 | 0.154 | 1 | 0.802 |
CDK19 |
0.745 | 0.114 | 1 | 0.727 |
MST4 |
0.745 | 0.036 | 2 | 0.412 |
CDK13 |
0.744 | 0.119 | 1 | 0.759 |
CAMK1G |
0.744 | 0.160 | -3 | 0.793 |
PKCA |
0.744 | 0.069 | 2 | 0.313 |
NEK6 |
0.743 | -0.043 | -2 | 0.785 |
SGK3 |
0.743 | 0.156 | -3 | 0.796 |
P38G |
0.743 | 0.143 | 1 | 0.683 |
DSTYK |
0.743 | -0.006 | 2 | 0.466 |
CDK12 |
0.743 | 0.133 | 1 | 0.733 |
IKKA |
0.742 | 0.027 | -2 | 0.660 |
PIM2 |
0.742 | 0.150 | -3 | 0.791 |
CDK17 |
0.742 | 0.127 | 1 | 0.692 |
GCN2 |
0.742 | -0.127 | 2 | 0.385 |
PKCZ |
0.742 | 0.084 | 2 | 0.341 |
PAK4 |
0.741 | 0.174 | -2 | 0.810 |
CAMK4 |
0.741 | 0.089 | -3 | 0.805 |
MOK |
0.741 | 0.219 | 1 | 0.867 |
GRK4 |
0.741 | 0.018 | -2 | 0.779 |
RIPK1 |
0.741 | 0.071 | 1 | 0.733 |
ERK2 |
0.740 | 0.123 | 1 | 0.776 |
DLK |
0.740 | 0.110 | 1 | 0.712 |
PRKD3 |
0.739 | 0.103 | -3 | 0.770 |
BMPR1B |
0.739 | 0.096 | 1 | 0.687 |
CDK5 |
0.739 | 0.100 | 1 | 0.794 |
AMPKA1 |
0.739 | 0.032 | -3 | 0.831 |
CDK3 |
0.739 | 0.119 | 1 | 0.711 |
BMPR2 |
0.739 | -0.099 | -2 | 0.819 |
JNK1 |
0.739 | 0.175 | 1 | 0.724 |
MLK1 |
0.738 | -0.048 | 2 | 0.385 |
TBK1 |
0.737 | -0.076 | 1 | 0.620 |
DCAMKL1 |
0.737 | 0.126 | -3 | 0.787 |
MLK3 |
0.737 | -0.010 | 2 | 0.338 |
DRAK1 |
0.737 | 0.176 | 1 | 0.636 |
AMPKA2 |
0.737 | 0.052 | -3 | 0.821 |
MASTL |
0.736 | -0.039 | -2 | 0.767 |
IKKE |
0.736 | -0.052 | 1 | 0.620 |
ULK2 |
0.736 | -0.145 | 2 | 0.339 |
TSSK2 |
0.736 | 0.029 | -5 | 0.812 |
DAPK1 |
0.736 | 0.237 | -3 | 0.809 |
PKCH |
0.736 | 0.055 | 2 | 0.315 |
CDK9 |
0.736 | 0.108 | 1 | 0.761 |
TSSK1 |
0.736 | 0.036 | -3 | 0.838 |
PAK5 |
0.735 | 0.152 | -2 | 0.792 |
NEK7 |
0.735 | -0.102 | -3 | 0.788 |
P38D |
0.735 | 0.153 | 1 | 0.701 |
MARK4 |
0.735 | -0.024 | 4 | 0.558 |
SGK1 |
0.734 | 0.191 | -3 | 0.714 |
DNAPK |
0.733 | 0.082 | 1 | 0.629 |
TGFBR1 |
0.733 | 0.051 | -2 | 0.756 |
PLK1 |
0.733 | 0.038 | -2 | 0.747 |
CDK16 |
0.732 | 0.115 | 1 | 0.713 |
PDHK1 |
0.732 | -0.172 | 1 | 0.745 |
MLK2 |
0.732 | -0.059 | 2 | 0.368 |
DAPK3 |
0.732 | 0.200 | -3 | 0.811 |
AKT1 |
0.732 | 0.163 | -3 | 0.770 |
PKCE |
0.732 | 0.114 | 2 | 0.330 |
TGFBR2 |
0.732 | -0.079 | -2 | 0.761 |
SMMLCK |
0.731 | 0.188 | -3 | 0.821 |
ULK1 |
0.731 | -0.115 | -3 | 0.746 |
IRE1 |
0.731 | -0.050 | 1 | 0.760 |
NIM1 |
0.731 | -0.035 | 3 | 0.710 |
BCKDK |
0.730 | -0.118 | -1 | 0.644 |
TTBK2 |
0.730 | -0.099 | 2 | 0.321 |
PKR |
0.730 | 0.040 | 1 | 0.784 |
CK1E |
0.730 | 0.026 | -3 | 0.519 |
P70S6K |
0.730 | 0.111 | -3 | 0.767 |
AKT3 |
0.729 | 0.171 | -3 | 0.727 |
ATM |
0.729 | 0.006 | 1 | 0.682 |
ALK4 |
0.729 | 0.012 | -2 | 0.779 |
BRSK1 |
0.729 | 0.025 | -3 | 0.794 |
MPSK1 |
0.729 | 0.102 | 1 | 0.810 |
CAMK1D |
0.729 | 0.142 | -3 | 0.737 |
PLK3 |
0.729 | 0.039 | 2 | 0.445 |
ANKRD3 |
0.729 | -0.067 | 1 | 0.749 |
WNK3 |
0.729 | -0.123 | 1 | 0.727 |
MAPKAPK5 |
0.728 | 0.066 | -3 | 0.779 |
GAK |
0.728 | 0.235 | 1 | 0.831 |
MRCKA |
0.727 | 0.193 | -3 | 0.782 |
QSK |
0.727 | 0.011 | 4 | 0.527 |
MELK |
0.727 | 0.023 | -3 | 0.800 |
MRCKB |
0.727 | 0.184 | -3 | 0.770 |
PHKG1 |
0.727 | -0.023 | -3 | 0.814 |
ALK2 |
0.727 | 0.052 | -2 | 0.765 |
ROCK2 |
0.726 | 0.192 | -3 | 0.804 |
DCAMKL2 |
0.726 | 0.065 | -3 | 0.795 |
VRK2 |
0.725 | -0.010 | 1 | 0.806 |
PRP4 |
0.725 | 0.065 | -3 | 0.677 |
NEK9 |
0.725 | -0.133 | 2 | 0.370 |
TLK2 |
0.725 | -0.020 | 1 | 0.712 |
PKCI |
0.725 | 0.073 | 2 | 0.328 |
CK1A2 |
0.724 | 0.042 | -3 | 0.480 |
CDK2 |
0.724 | 0.041 | 1 | 0.795 |
ERK7 |
0.724 | 0.004 | 2 | 0.233 |
CK1D |
0.724 | 0.039 | -3 | 0.477 |
GRK2 |
0.724 | 0.012 | -2 | 0.678 |
MARK3 |
0.724 | 0.015 | 4 | 0.494 |
NUAK1 |
0.723 | -0.002 | -3 | 0.802 |
QIK |
0.723 | -0.034 | -3 | 0.812 |
BUB1 |
0.723 | 0.151 | -5 | 0.776 |
CHAK1 |
0.722 | -0.073 | 2 | 0.337 |
DMPK1 |
0.722 | 0.226 | -3 | 0.780 |
MST3 |
0.722 | 0.056 | 2 | 0.434 |
MEK1 |
0.722 | -0.046 | 2 | 0.434 |
MLK4 |
0.722 | -0.073 | 2 | 0.317 |
PKCT |
0.722 | 0.049 | 2 | 0.308 |
NEK2 |
0.721 | -0.059 | 2 | 0.358 |
CK2A1 |
0.721 | 0.124 | 1 | 0.596 |
MEKK3 |
0.721 | 0.049 | 1 | 0.691 |
SMG1 |
0.721 | -0.034 | 1 | 0.716 |
BRSK2 |
0.721 | -0.033 | -3 | 0.798 |
CK1G1 |
0.720 | 0.006 | -3 | 0.491 |
PLK4 |
0.720 | -0.068 | 2 | 0.321 |
CK2A2 |
0.720 | 0.080 | 1 | 0.618 |
YSK4 |
0.720 | -0.037 | 1 | 0.670 |
SIK |
0.720 | 0.005 | -3 | 0.776 |
SNRK |
0.720 | -0.064 | 2 | 0.315 |
GRK3 |
0.719 | 0.033 | -2 | 0.648 |
BMPR1A |
0.719 | 0.053 | 1 | 0.654 |
STK33 |
0.719 | 0.026 | 2 | 0.323 |
YANK3 |
0.718 | 0.021 | 2 | 0.242 |
WNK4 |
0.718 | -0.001 | -2 | 0.846 |
ACVR2B |
0.718 | 0.001 | -2 | 0.733 |
SSTK |
0.716 | -0.004 | 4 | 0.512 |
CHK1 |
0.716 | -0.002 | -3 | 0.805 |
SBK |
0.716 | 0.156 | -3 | 0.676 |
IRE2 |
0.715 | -0.108 | 2 | 0.291 |
HASPIN |
0.715 | 0.187 | -1 | 0.834 |
ACVR2A |
0.715 | -0.033 | -2 | 0.723 |
LKB1 |
0.715 | 0.059 | -3 | 0.774 |
PINK1 |
0.714 | -0.049 | 1 | 0.855 |
NEK5 |
0.714 | -0.035 | 1 | 0.747 |
CHK2 |
0.714 | 0.125 | -3 | 0.708 |
CDK4 |
0.713 | 0.100 | 1 | 0.733 |
CRIK |
0.713 | 0.162 | -3 | 0.788 |
CAMK1A |
0.713 | 0.122 | -3 | 0.715 |
MARK1 |
0.712 | -0.028 | 4 | 0.508 |
MEK5 |
0.712 | -0.084 | 2 | 0.396 |
ROCK1 |
0.711 | 0.173 | -3 | 0.775 |
CDK6 |
0.711 | 0.080 | 1 | 0.750 |
PLK2 |
0.711 | 0.033 | -3 | 0.645 |
PERK |
0.710 | -0.119 | -2 | 0.762 |
IRAK4 |
0.710 | -0.058 | 1 | 0.739 |
MARK2 |
0.710 | -0.063 | 4 | 0.462 |
TLK1 |
0.710 | -0.076 | -2 | 0.769 |
TAO3 |
0.710 | -0.017 | 1 | 0.701 |
PDK1 |
0.709 | 0.027 | 1 | 0.696 |
NEK11 |
0.708 | -0.022 | 1 | 0.676 |
GCK |
0.707 | 0.078 | 1 | 0.697 |
CK1A |
0.707 | 0.051 | -3 | 0.391 |
PKG1 |
0.707 | 0.117 | -2 | 0.726 |
NEK8 |
0.706 | -0.055 | 2 | 0.372 |
CAMKK2 |
0.706 | 0.011 | -2 | 0.694 |
TTBK1 |
0.706 | -0.116 | 2 | 0.290 |
PHKG2 |
0.706 | -0.033 | -3 | 0.773 |
MEKK2 |
0.705 | -0.112 | 2 | 0.360 |
PKN1 |
0.705 | 0.047 | -3 | 0.772 |
ZAK |
0.704 | -0.136 | 1 | 0.658 |
CAMKK1 |
0.704 | -0.042 | -2 | 0.687 |
BRAF |
0.704 | -0.102 | -4 | 0.784 |
HPK1 |
0.703 | 0.064 | 1 | 0.685 |
SLK |
0.702 | 0.017 | -2 | 0.693 |
MEKK1 |
0.701 | -0.171 | 1 | 0.699 |
LRRK2 |
0.701 | 0.003 | 2 | 0.399 |
PBK |
0.700 | 0.067 | 1 | 0.775 |
TAK1 |
0.698 | 0.032 | 1 | 0.708 |
HRI |
0.698 | -0.187 | -2 | 0.775 |
LOK |
0.697 | -0.019 | -2 | 0.746 |
VRK1 |
0.696 | -0.025 | 2 | 0.409 |
MEKK6 |
0.696 | -0.083 | 1 | 0.705 |
EEF2K |
0.696 | -0.057 | 3 | 0.705 |
KHS2 |
0.696 | 0.030 | 1 | 0.700 |
MAP3K15 |
0.695 | -0.073 | 1 | 0.656 |
TNIK |
0.694 | -0.036 | 3 | 0.749 |
PDHK4_TYR |
0.694 | 0.306 | 2 | 0.481 |
NEK4 |
0.693 | -0.099 | 1 | 0.701 |
PDHK3_TYR |
0.693 | 0.279 | 4 | 0.697 |
NEK1 |
0.693 | -0.051 | 1 | 0.720 |
TAO2 |
0.692 | -0.120 | 2 | 0.379 |
MST2 |
0.691 | -0.073 | 1 | 0.690 |
KHS1 |
0.690 | -0.010 | 1 | 0.687 |
HGK |
0.687 | -0.095 | 3 | 0.744 |
MINK |
0.687 | -0.092 | 1 | 0.687 |
MAP2K6_TYR |
0.686 | 0.231 | -1 | 0.714 |
IRAK1 |
0.686 | -0.196 | -1 | 0.656 |
MST1 |
0.685 | -0.064 | 1 | 0.683 |
BIKE |
0.685 | 0.058 | 1 | 0.763 |
CK1G3 |
0.682 | 0.038 | -3 | 0.349 |
OSR1 |
0.682 | -0.066 | 2 | 0.376 |
MAP2K4_TYR |
0.681 | 0.112 | -1 | 0.712 |
MEK2 |
0.680 | -0.171 | 2 | 0.379 |
PDHK1_TYR |
0.680 | 0.108 | -1 | 0.734 |
YSK1 |
0.679 | -0.113 | 2 | 0.355 |
TESK1_TYR |
0.679 | 0.043 | 3 | 0.800 |
RIPK2 |
0.678 | -0.145 | 1 | 0.600 |
LIMK2_TYR |
0.678 | 0.064 | -3 | 0.815 |
BMPR2_TYR |
0.678 | 0.115 | -1 | 0.711 |
YANK2 |
0.678 | -0.017 | 2 | 0.233 |
TTK |
0.676 | -0.086 | -2 | 0.782 |
MAP2K7_TYR |
0.676 | 0.036 | 2 | 0.432 |
ALPHAK3 |
0.675 | 0.003 | -1 | 0.619 |
MYO3B |
0.674 | -0.060 | 2 | 0.357 |
AAK1 |
0.673 | 0.081 | 1 | 0.698 |
CK1G2 |
0.672 | 0.054 | -3 | 0.425 |
PKMYT1_TYR |
0.672 | -0.044 | 3 | 0.784 |
ASK1 |
0.671 | -0.099 | 1 | 0.644 |
PINK1_TYR |
0.671 | -0.039 | 1 | 0.772 |
EPHA4 |
0.667 | 0.064 | 2 | 0.475 |
EPHA6 |
0.666 | -0.012 | -1 | 0.697 |
NEK3 |
0.665 | -0.184 | 1 | 0.661 |
EPHB4 |
0.664 | 0.014 | -1 | 0.660 |
TNK2 |
0.664 | 0.035 | 3 | 0.684 |
RET |
0.663 | -0.063 | 1 | 0.722 |
DDR1 |
0.662 | -0.011 | 4 | 0.608 |
MYO3A |
0.662 | -0.120 | 1 | 0.709 |
LIMK1_TYR |
0.661 | -0.119 | 2 | 0.375 |
YES1 |
0.659 | -0.023 | -1 | 0.692 |
ABL2 |
0.659 | -0.037 | -1 | 0.662 |
TAO1 |
0.659 | -0.131 | 1 | 0.621 |
TNK1 |
0.658 | -0.006 | 3 | 0.709 |
TXK |
0.658 | 0.038 | 1 | 0.697 |
MST1R |
0.657 | -0.120 | 3 | 0.745 |
SRMS |
0.657 | 0.040 | 1 | 0.714 |
DDR2 |
0.657 | 0.098 | 3 | 0.662 |
FGR |
0.656 | -0.075 | 1 | 0.761 |
ABL1 |
0.655 | -0.056 | -1 | 0.656 |
FYN |
0.655 | 0.047 | -1 | 0.650 |
PTK2 |
0.654 | 0.063 | -1 | 0.615 |
BLK |
0.654 | 0.007 | -1 | 0.683 |
FLT1 |
0.653 | 0.016 | -1 | 0.664 |
KDR |
0.653 | -0.058 | 3 | 0.688 |
FGFR2 |
0.653 | -0.071 | 3 | 0.743 |
STLK3 |
0.652 | -0.175 | 1 | 0.625 |
EPHB1 |
0.652 | -0.014 | 1 | 0.694 |
CSF1R |
0.651 | -0.108 | 3 | 0.713 |
EPHB3 |
0.651 | -0.030 | -1 | 0.642 |
EPHA3 |
0.651 | -0.028 | 2 | 0.431 |
EPHB2 |
0.651 | -0.020 | -1 | 0.638 |
TYRO3 |
0.650 | -0.165 | 3 | 0.708 |
EPHA7 |
0.650 | -0.011 | 2 | 0.438 |
ITK |
0.650 | 0.006 | -1 | 0.633 |
LCK |
0.649 | -0.046 | -1 | 0.667 |
KIT |
0.649 | -0.055 | 3 | 0.714 |
INSRR |
0.649 | -0.098 | 3 | 0.676 |
NEK10_TYR |
0.649 | -0.078 | 1 | 0.634 |
EPHA5 |
0.649 | 0.027 | 2 | 0.460 |
JAK3 |
0.648 | -0.110 | 1 | 0.687 |
WEE1_TYR |
0.648 | -0.055 | -1 | 0.608 |
JAK2 |
0.648 | -0.210 | 1 | 0.703 |
FER |
0.647 | -0.147 | 1 | 0.750 |
HCK |
0.647 | -0.098 | -1 | 0.659 |
MERTK |
0.647 | -0.079 | 3 | 0.727 |
FGFR3 |
0.647 | -0.039 | 3 | 0.715 |
BMX |
0.647 | 0.013 | -1 | 0.568 |
MET |
0.647 | -0.069 | 3 | 0.721 |
TYK2 |
0.646 | -0.271 | 1 | 0.714 |
ROS1 |
0.645 | -0.239 | 3 | 0.680 |
PTK2B |
0.644 | -0.004 | -1 | 0.631 |
SYK |
0.644 | 0.052 | -1 | 0.600 |
TEK |
0.644 | -0.106 | 3 | 0.652 |
AXL |
0.642 | -0.121 | 3 | 0.710 |
EPHA8 |
0.641 | -0.023 | -1 | 0.643 |
SRC |
0.641 | -0.022 | -1 | 0.653 |
TEC |
0.640 | -0.066 | -1 | 0.592 |
ERBB2 |
0.640 | -0.104 | 1 | 0.670 |
EPHA2 |
0.639 | 0.010 | -1 | 0.594 |
FGFR1 |
0.638 | -0.172 | 3 | 0.699 |
FLT3 |
0.638 | -0.176 | 3 | 0.703 |
FLT4 |
0.638 | -0.107 | 3 | 0.696 |
MATK |
0.637 | -0.073 | -1 | 0.620 |
FRK |
0.637 | -0.086 | -1 | 0.688 |
PTK6 |
0.637 | -0.188 | -1 | 0.575 |
EPHA1 |
0.636 | -0.113 | 3 | 0.702 |
PDGFRB |
0.636 | -0.236 | 3 | 0.713 |
NTRK1 |
0.636 | -0.152 | -1 | 0.632 |
LYN |
0.636 | -0.073 | 3 | 0.647 |
LTK |
0.636 | -0.154 | 3 | 0.680 |
TNNI3K_TYR |
0.635 | -0.169 | 1 | 0.705 |
BTK |
0.635 | -0.144 | -1 | 0.608 |
CSK |
0.634 | -0.064 | 2 | 0.425 |
FGFR4 |
0.634 | -0.051 | -1 | 0.602 |
EGFR |
0.634 | -0.060 | 1 | 0.577 |
JAK1 |
0.632 | -0.187 | 1 | 0.633 |
PDGFRA |
0.631 | -0.260 | 3 | 0.713 |
ERBB4 |
0.629 | -0.019 | 1 | 0.590 |
ALK |
0.628 | -0.215 | 3 | 0.643 |
ZAP70 |
0.626 | 0.019 | -1 | 0.535 |
NTRK3 |
0.625 | -0.158 | -1 | 0.588 |
INSR |
0.625 | -0.197 | 3 | 0.657 |
NTRK2 |
0.621 | -0.248 | 3 | 0.685 |
IGF1R |
0.616 | -0.152 | 3 | 0.609 |
MUSK |
0.614 | -0.152 | 1 | 0.595 |
FES |
0.607 | -0.120 | -1 | 0.548 |