Motif 450 (n=110)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O14641 | DVL2 | S141 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14757 | CHEK1 | S316 | ochoa | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}. |
| O15056 | SYNJ2 | S1137 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O15534 | PER1 | S830 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O60238 | BNIP3L | S97 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O60292 | SIPA1L3 | S1559 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60293 | ZFC3H1 | S729 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O94913 | PCF11 | S184 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94967 | WDR47 | S359 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95382 | MAP3K6 | S1129 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| O95863 | SNAI1 | S111 | psp | Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:25827072}. |
| P10398 | ARAF | S172 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P27816 | MAP4 | S914 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29401 | TKT | S295 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P34910 | EVI2B | S278 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P42858 | HTT | S432 | ochoa|psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46013 | MKI67 | S1704 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49918 | CDKN1C | S297 | ochoa | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| P52272 | HNRNPM | S528 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52594 | AGFG1 | S162 | ochoa | Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) | Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}. |
| P56524 | HDAC4 | S224 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P68363 | TUBA1B | T73 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q02880 | TOP2B | S1476 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q05209 | PTPN12 | S571 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08174 | PCDH1 | S1021 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q08357 | SLC20A2 | S268 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08AD1 | CAMSAP2 | S1319 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q08AD1 | CAMSAP2 | S1340 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12802 | AKAP13 | S1617 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | S330 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13131 | PRKAA1 | S523 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13501 | SQSTM1 | S306 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q14674 | ESPL1 | S1528 | ochoa | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q14980 | NUMA1 | S1862 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15052 | ARHGEF6 | S141 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15334 | LLGL1 | S683 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15424 | SAFB | S21 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15751 | HERC1 | S1529 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q16512 | PKN1 | S591 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q5PRF9 | SAMD4B | S607 | ochoa|psp | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5SW79 | CEP170 | S252 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SW79 | CEP170 | S1225 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T200 | ZC3H13 | S348 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5THJ4 | VPS13D | S1727 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S1437 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT25 | CDC42BPA | S1666 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5XKK7 | FAM219B | S140 | ochoa | Protein FAM219B | None |
| Q6NUJ5 | PWWP2B | S456 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6P996 | PDXDC1 | S737 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6ZSR9 | None | S300 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q6ZTU2 | EP400P1 | S185 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q70CQ2 | USP34 | S1473 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q71U36 | TUBA1A | T73 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q76L83 | ASXL2 | S580 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7L9B9 | EEPD1 | S31 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z3B3 | KANSL1 | S994 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z3K3 | POGZ | S266 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z628 | NET1 | S36 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z6B0 | CCDC91 | S79 | ochoa | Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) | Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}. |
| Q86TI0 | TBC1D1 | S585 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86UU0 | BCL9L | S131 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86YV5 | PRAG1 | S510 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IWC1 | MAP7D3 | S509 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8N488 | RYBP | S130 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8NC51 | SERBP1 | S234 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NHV4 | NEDD1 | S525 | ochoa | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TB72 | PUM2 | S82 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8WWQ0 | PHIP | S692 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WXG6 | MADD | S839 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q8WYP5 | AHCTF1 | S1548 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WYQ5 | DGCR8 | S383 | ochoa | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92508 | PIEZO1 | S1636 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92614 | MYO18A | S164 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92619 | ARHGAP45 | S592 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92945 | KHSRP | S144 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96CC6 | RHBDF1 | S61 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96CP6 | GRAMD1A | S267 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96JB2 | COG3 | S531 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96JB2 | COG3 | S546 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96L91 | EP400 | S196 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96MG7 | NSMCE3 | S64 | ochoa | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}. |
| Q96QD8 | SLC38A2 | S39 | ochoa | Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) | Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity). {ECO:0000250|UniProtKB:Q8CFE6, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15774260, ECO:0000269|PubMed:15922329, ECO:0000269|PubMed:16621798}. |
| Q9BQE3 | TUBA1C | T73 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9C0B5 | ZDHHC5 | S395 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0D5 | TANC1 | S319 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H2Y7 | ZNF106 | S878 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H5V8 | CDCP1 | S818 | ochoa | CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318) | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}. |
| Q9H6B4 | CLMP | S334 | ochoa | CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein) | May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. {ECO:0000269|PubMed:14573622, ECO:0000269|PubMed:15563274, ECO:0000269|PubMed:22155368}. |
| Q9H6Z4 | RANBP3 | S372 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9NQ84 | GPRC5C | S418 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NQX3 | GPHN | S295 | ochoa | Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}. |
| Q9NRL2 | BAZ1A | S1417 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NXD2 | MTMR10 | S622 | ochoa | Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) | None |
| Q9P209 | CEP72 | S387 | ochoa | Centrosomal protein of 72 kDa (Cep72) | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}. |
| Q9P270 | SLAIN2 | S160 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2D0 | IBTK | S1054 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9UDY2 | TJP2 | S413 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGU0 | TCF20 | S559 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHB6 | LIMA1 | S619 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UKV5 | AMFR | S522 | ochoa | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296). Required for proper lipid homeostasis (PubMed:37119330). {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:12670940, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:17043353, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:31073040, ECO:0000269|PubMed:31953408, ECO:0000269|PubMed:36593296, ECO:0000269|PubMed:37119330}. |
| Q9ULU4 | ZMYND8 | S475 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UPN3 | MACF1 | S7345 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPN4 | CEP131 | S120 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UQ35 | SRRM2 | S2436 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y4G6 | TLN2 | S473 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y4H2 | IRS2 | S1164 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| P0DPH7 | TUBA3C | T73 | Sugiyama | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PEY2 | TUBA3E | T73 | Sugiyama | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q8TEW0 | PARD3 | S730 | Sugiyama | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q96S53 | TESK2 | S48 | Sugiyama | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.408840e-08 | 7.130 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.047352e-07 | 6.516 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 8.993135e-07 | 6.046 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.116329e-06 | 5.952 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.673266e-06 | 5.776 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.038839e-06 | 5.394 |
| R-HSA-68877 | Mitotic Prometaphase | 6.069029e-06 | 5.217 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.104518e-05 | 4.957 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.419739e-05 | 4.848 |
| R-HSA-190861 | Gap junction assembly | 1.801057e-05 | 4.744 |
| R-HSA-9646399 | Aggrephagy | 3.437750e-05 | 4.464 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.163242e-05 | 4.381 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.183057e-05 | 4.379 |
| R-HSA-190828 | Gap junction trafficking | 5.528731e-05 | 4.257 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 7.186553e-05 | 4.143 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.555687e-05 | 4.183 |
| R-HSA-437239 | Recycling pathway of L1 | 7.186553e-05 | 4.143 |
| R-HSA-157858 | Gap junction trafficking and regulation | 8.488200e-05 | 4.071 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.051670e-04 | 3.978 |
| R-HSA-9663891 | Selective autophagy | 1.112244e-04 | 3.954 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.350067e-04 | 3.870 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.883910e-04 | 3.725 |
| R-HSA-69275 | G2/M Transition | 1.941649e-04 | 3.712 |
| R-HSA-983189 | Kinesins | 1.918888e-04 | 3.717 |
| R-HSA-5617833 | Cilium Assembly | 2.209845e-04 | 3.656 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.191487e-04 | 3.659 |
| R-HSA-1632852 | Macroautophagy | 2.306413e-04 | 3.637 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.072183e-04 | 3.684 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.518566e-04 | 3.599 |
| R-HSA-68886 | M Phase | 2.838181e-04 | 3.547 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.188281e-04 | 3.496 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.613905e-04 | 3.442 |
| R-HSA-9612973 | Autophagy | 4.100110e-04 | 3.387 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.799698e-04 | 3.420 |
| R-HSA-1640170 | Cell Cycle | 4.699175e-04 | 3.328 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.342883e-04 | 3.272 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.394798e-04 | 3.194 |
| R-HSA-9833482 | PKR-mediated signaling | 6.171951e-04 | 3.210 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 9.086772e-04 | 3.042 |
| R-HSA-5620924 | Intraflagellar transport | 9.553789e-04 | 3.020 |
| R-HSA-391251 | Protein folding | 1.186736e-03 | 2.926 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.462848e-03 | 2.835 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.504238e-03 | 2.823 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 1.779251e-03 | 2.750 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.867148e-03 | 2.729 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.987761e-03 | 2.702 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.772896e-03 | 2.751 |
| R-HSA-73887 | Death Receptor Signaling | 2.179268e-03 | 2.662 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.261776e-03 | 2.646 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.261776e-03 | 2.646 |
| R-HSA-68882 | Mitotic Anaphase | 2.353412e-03 | 2.628 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.409102e-03 | 2.618 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.622750e-03 | 2.581 |
| R-HSA-373760 | L1CAM interactions | 3.372816e-03 | 2.472 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.614841e-03 | 2.442 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.614841e-03 | 2.442 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.921619e-03 | 2.407 |
| R-HSA-380287 | Centrosome maturation | 3.939263e-03 | 2.405 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.203972e-03 | 2.376 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.643825e-03 | 2.248 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.761630e-03 | 2.322 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.013358e-03 | 2.300 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.791325e-03 | 2.237 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 6.041061e-03 | 2.219 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 6.498266e-03 | 2.187 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.966964e-03 | 2.157 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.267011e-03 | 2.139 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.268405e-03 | 2.139 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.097534e-03 | 2.041 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 9.334335e-03 | 2.030 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.149354e-02 | 1.940 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.039386e-02 | 1.983 |
| R-HSA-2028269 | Signaling by Hippo | 1.255199e-02 | 1.901 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.071499e-02 | 1.970 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.063950e-02 | 1.973 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.333634e-02 | 1.875 |
| R-HSA-199991 | Membrane Trafficking | 1.377727e-02 | 1.861 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.042069e-02 | 1.690 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 2.265652e-02 | 1.645 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 2.265652e-02 | 1.645 |
| R-HSA-9609690 | HCMV Early Events | 2.515969e-02 | 1.599 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.542975e-02 | 1.595 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.675174e-02 | 1.573 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.870577e-02 | 1.542 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.870577e-02 | 1.542 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 3.009496e-02 | 1.522 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 3.747725e-02 | 1.426 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.130281e-02 | 1.504 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.130137e-02 | 1.384 |
| R-HSA-162582 | Signal Transduction | 3.300658e-02 | 1.481 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.137155e-02 | 1.503 |
| R-HSA-112316 | Neuronal System | 3.450752e-02 | 1.462 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.164985e-02 | 1.500 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.280220e-02 | 1.369 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.877775e-02 | 1.312 |
| R-HSA-74713 | IRS activation | 5.207503e-02 | 1.283 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 5.207503e-02 | 1.283 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.302070e-02 | 1.276 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.412455e-02 | 1.267 |
| R-HSA-9609646 | HCMV Infection | 5.688253e-02 | 1.245 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 5.929135e-02 | 1.227 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 5.929135e-02 | 1.227 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.465613e-02 | 1.189 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 6.645319e-02 | 1.177 |
| R-HSA-112412 | SOS-mediated signalling | 7.356094e-02 | 1.133 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 7.356094e-02 | 1.133 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 8.061501e-02 | 1.094 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 8.061501e-02 | 1.094 |
| R-HSA-201688 | WNT mediated activation of DVL | 8.761580e-02 | 1.057 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 9.456372e-02 | 1.024 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.083025e-01 | 0.965 |
| R-HSA-198203 | PI3K/AKT activation | 9.456372e-02 | 1.024 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 7.356094e-02 | 1.133 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.083025e-01 | 0.965 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.348020e-02 | 1.029 |
| R-HSA-74749 | Signal attenuation | 9.456372e-02 | 1.024 |
| R-HSA-9664873 | Pexophagy | 9.456372e-02 | 1.024 |
| R-HSA-69481 | G2/M Checkpoints | 9.570115e-02 | 1.019 |
| R-HSA-9909396 | Circadian clock | 1.049641e-01 | 0.979 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.279895e-02 | 1.138 |
| R-HSA-5693538 | Homology Directed Repair | 8.106732e-02 | 1.091 |
| R-HSA-2586552 | Signaling by Leptin | 9.456372e-02 | 1.024 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 8.061501e-02 | 1.094 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 8.761580e-02 | 1.057 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 9.114778e-02 | 1.040 |
| R-HSA-75893 | TNF signaling | 8.653635e-02 | 1.063 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.127292e-01 | 0.948 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.150941e-01 | 0.939 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.150941e-01 | 0.939 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.150941e-01 | 0.939 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.150941e-01 | 0.939 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.150941e-01 | 0.939 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.150941e-01 | 0.939 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.218345e-01 | 0.914 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.351627e-01 | 0.869 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.351627e-01 | 0.869 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.417514e-01 | 0.848 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 1.482903e-01 | 0.829 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.348110e-01 | 0.629 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.417514e-01 | 0.848 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.926995e-01 | 0.715 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.406463e-01 | 0.619 |
| R-HSA-9664420 | Killing mechanisms | 1.417514e-01 | 0.848 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.417514e-01 | 0.848 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.170369e-01 | 0.663 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.482903e-01 | 0.829 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.230066e-01 | 0.652 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.261721e-01 | 0.899 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.218345e-01 | 0.914 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.218345e-01 | 0.914 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.926995e-01 | 0.715 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.351627e-01 | 0.869 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.612203e-01 | 0.793 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.170369e-01 | 0.663 |
| R-HSA-420029 | Tight junction interactions | 2.110216e-01 | 0.676 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.406463e-01 | 0.619 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.406463e-01 | 0.619 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.049606e-01 | 0.688 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.285239e-01 | 0.891 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.012666e-01 | 0.696 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.643439e-01 | 0.784 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.218345e-01 | 0.914 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.194659e-01 | 0.659 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.289312e-01 | 0.640 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 1.864989e-01 | 0.729 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.289312e-01 | 0.640 |
| R-HSA-3214847 | HATs acetylate histones | 2.055304e-01 | 0.687 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.110216e-01 | 0.676 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.170369e-01 | 0.663 |
| R-HSA-112311 | Neurotransmitter clearance | 2.406463e-01 | 0.619 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 2.230066e-01 | 0.652 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.351627e-01 | 0.869 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.676120e-01 | 0.776 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.791835e-01 | 0.747 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.272644e-01 | 0.643 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.110216e-01 | 0.676 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.644784e-01 | 0.784 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.406463e-01 | 0.619 |
| R-HSA-1483255 | PI Metabolism | 2.138807e-01 | 0.670 |
| R-HSA-5619102 | SLC transporter disorders | 1.688447e-01 | 0.773 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.328931e-01 | 0.876 |
| R-HSA-597592 | Post-translational protein modification | 2.111805e-01 | 0.675 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.688016e-01 | 0.773 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.110216e-01 | 0.676 |
| R-HSA-2262752 | Cellular responses to stress | 1.710069e-01 | 0.767 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.988533e-01 | 0.701 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.348110e-01 | 0.629 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.803873e-01 | 0.744 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.380562e-01 | 0.860 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.780065e-01 | 0.750 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 2.161994e-01 | 0.665 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.416841e-01 | 0.849 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.406463e-01 | 0.619 |
| R-HSA-913531 | Interferon Signaling | 1.973412e-01 | 0.705 |
| R-HSA-182971 | EGFR downregulation | 2.464375e-01 | 0.608 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.521849e-01 | 0.598 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.521849e-01 | 0.598 |
| R-HSA-397795 | G-protein beta:gamma signalling | 2.578888e-01 | 0.589 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.578888e-01 | 0.589 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.578888e-01 | 0.589 |
| R-HSA-9930044 | Nuclear RNA decay | 2.578888e-01 | 0.589 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.578888e-01 | 0.589 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.578888e-01 | 0.589 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.578888e-01 | 0.589 |
| R-HSA-422475 | Axon guidance | 2.651590e-01 | 0.576 |
| R-HSA-5673000 | RAF activation | 2.691674e-01 | 0.570 |
| R-HSA-5205647 | Mitophagy | 2.691674e-01 | 0.570 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.691674e-01 | 0.570 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.747428e-01 | 0.561 |
| R-HSA-381042 | PERK regulates gene expression | 2.747428e-01 | 0.561 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.747428e-01 | 0.561 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.747428e-01 | 0.561 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.802760e-01 | 0.552 |
| R-HSA-8853659 | RET signaling | 2.802760e-01 | 0.552 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.802760e-01 | 0.552 |
| R-HSA-4641258 | Degradation of DVL | 2.857673e-01 | 0.544 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.857673e-01 | 0.544 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.857673e-01 | 0.544 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.912171e-01 | 0.536 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.912171e-01 | 0.536 |
| R-HSA-71336 | Pentose phosphate pathway | 2.966256e-01 | 0.528 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.073201e-01 | 0.512 |
| R-HSA-9694548 | Maturation of spike protein | 3.073201e-01 | 0.512 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.126067e-01 | 0.505 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.126067e-01 | 0.505 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.126067e-01 | 0.505 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.126067e-01 | 0.505 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.126067e-01 | 0.505 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.126067e-01 | 0.505 |
| R-HSA-9675108 | Nervous system development | 3.139274e-01 | 0.503 |
| R-HSA-165159 | MTOR signalling | 3.178533e-01 | 0.498 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.230602e-01 | 0.491 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.282277e-01 | 0.484 |
| R-HSA-69236 | G1 Phase | 3.282277e-01 | 0.484 |
| R-HSA-73894 | DNA Repair | 3.306774e-01 | 0.481 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.333560e-01 | 0.477 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.333560e-01 | 0.477 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.333560e-01 | 0.477 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.340791e-01 | 0.476 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.384455e-01 | 0.471 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.384455e-01 | 0.471 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.384455e-01 | 0.471 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.384455e-01 | 0.471 |
| R-HSA-75153 | Apoptotic execution phase | 3.384455e-01 | 0.471 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.434964e-01 | 0.464 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.534839e-01 | 0.452 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.534839e-01 | 0.452 |
| R-HSA-109704 | PI3K Cascade | 3.584209e-01 | 0.446 |
| R-HSA-9758941 | Gastrulation | 3.650190e-01 | 0.438 |
| R-HSA-72187 | mRNA 3'-end processing | 3.681831e-01 | 0.434 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.681831e-01 | 0.434 |
| R-HSA-177929 | Signaling by EGFR | 3.872676e-01 | 0.412 |
| R-HSA-112399 | IRS-mediated signalling | 3.919487e-01 | 0.407 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.948454e-01 | 0.404 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.965944e-01 | 0.402 |
| R-HSA-446728 | Cell junction organization | 3.983284e-01 | 0.400 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.003798e-01 | 0.398 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.012048e-01 | 0.397 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.057803e-01 | 0.392 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.057803e-01 | 0.392 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.057803e-01 | 0.392 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.057803e-01 | 0.392 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.057803e-01 | 0.392 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.057803e-01 | 0.392 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.057803e-01 | 0.392 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.057803e-01 | 0.392 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.103211e-01 | 0.387 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.103211e-01 | 0.387 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.148274e-01 | 0.382 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.148274e-01 | 0.382 |
| R-HSA-186797 | Signaling by PDGF | 4.148274e-01 | 0.382 |
| R-HSA-109582 | Hemostasis | 4.181776e-01 | 0.379 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.192997e-01 | 0.377 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.237380e-01 | 0.373 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.237380e-01 | 0.373 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.281426e-01 | 0.368 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.281426e-01 | 0.368 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.368520e-01 | 0.360 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.368520e-01 | 0.360 |
| R-HSA-195721 | Signaling by WNT | 4.389563e-01 | 0.358 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.496700e-01 | 0.347 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.580542e-01 | 0.339 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.598717e-01 | 0.337 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.663116e-01 | 0.331 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.703934e-01 | 0.328 |
| R-HSA-5689603 | UCH proteinases | 4.744442e-01 | 0.324 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.744442e-01 | 0.324 |
| R-HSA-1500931 | Cell-Cell communication | 4.746327e-01 | 0.324 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.784643e-01 | 0.320 |
| R-HSA-4086400 | PCP/CE pathway | 4.824539e-01 | 0.317 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.850696e-01 | 0.314 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.903425e-01 | 0.310 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.903425e-01 | 0.310 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.095460e-01 | 0.293 |
| R-HSA-72172 | mRNA Splicing | 5.116981e-01 | 0.291 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.132997e-01 | 0.290 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.132997e-01 | 0.290 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.132997e-01 | 0.290 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.132997e-01 | 0.290 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.170249e-01 | 0.286 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.316449e-01 | 0.274 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.423211e-01 | 0.266 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.423211e-01 | 0.266 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.493041e-01 | 0.260 |
| R-HSA-8951664 | Neddylation | 5.510552e-01 | 0.259 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.629546e-01 | 0.250 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.629546e-01 | 0.250 |
| R-HSA-190236 | Signaling by FGFR | 5.663027e-01 | 0.247 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.729226e-01 | 0.242 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.761949e-01 | 0.239 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.796317e-01 | 0.237 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.858634e-01 | 0.232 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.984151e-01 | 0.223 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.984151e-01 | 0.223 |
| R-HSA-211000 | Gene Silencing by RNA | 5.984151e-01 | 0.223 |
| R-HSA-4839726 | Chromatin organization | 6.109388e-01 | 0.214 |
| R-HSA-421270 | Cell-cell junction organization | 6.149778e-01 | 0.211 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.194792e-01 | 0.208 |
| R-HSA-5688426 | Deubiquitination | 6.229603e-01 | 0.206 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.252936e-01 | 0.204 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.338504e-01 | 0.198 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.366594e-01 | 0.196 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.394470e-01 | 0.194 |
| R-HSA-68875 | Mitotic Prophase | 6.422133e-01 | 0.192 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.503868e-01 | 0.187 |
| R-HSA-114608 | Platelet degranulation | 6.635996e-01 | 0.178 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.661821e-01 | 0.176 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.712883e-01 | 0.173 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.812694e-01 | 0.167 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.857356e-01 | 0.164 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.909498e-01 | 0.161 |
| R-HSA-163685 | Integration of energy metabolism | 6.909498e-01 | 0.161 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.958889e-01 | 0.157 |
| R-HSA-1483257 | Phospholipid metabolism | 6.958889e-01 | 0.157 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.975548e-01 | 0.156 |
| R-HSA-6807070 | PTEN Regulation | 6.980182e-01 | 0.156 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.980182e-01 | 0.156 |
| R-HSA-1280218 | Adaptive Immune System | 7.132901e-01 | 0.147 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.160930e-01 | 0.145 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.177163e-01 | 0.144 |
| R-HSA-166520 | Signaling by NTRKs | 7.204414e-01 | 0.142 |
| R-HSA-449147 | Signaling by Interleukins | 7.313379e-01 | 0.136 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.330941e-01 | 0.135 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.451787e-01 | 0.128 |
| R-HSA-109581 | Apoptosis | 7.490850e-01 | 0.125 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.663924e-01 | 0.116 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.695317e-01 | 0.114 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.713064e-01 | 0.113 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.713064e-01 | 0.113 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.713064e-01 | 0.113 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.714270e-01 | 0.113 |
| R-HSA-212436 | Generic Transcription Pathway | 7.724024e-01 | 0.112 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.729989e-01 | 0.112 |
| R-HSA-392499 | Metabolism of proteins | 7.760992e-01 | 0.110 |
| R-HSA-2559583 | Cellular Senescence | 7.833555e-01 | 0.106 |
| R-HSA-8953854 | Metabolism of RNA | 7.881998e-01 | 0.103 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.930646e-01 | 0.101 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.085833e-01 | 0.092 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.144207e-01 | 0.089 |
| R-HSA-5357801 | Programmed Cell Death | 8.228474e-01 | 0.085 |
| R-HSA-418990 | Adherens junctions interactions | 8.398253e-01 | 0.076 |
| R-HSA-74160 | Gene expression (Transcription) | 8.453312e-01 | 0.073 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.494604e-01 | 0.071 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.540601e-01 | 0.069 |
| R-HSA-157118 | Signaling by NOTCH | 8.649585e-01 | 0.063 |
| R-HSA-9824446 | Viral Infection Pathways | 8.787422e-01 | 0.056 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.807406e-01 | 0.055 |
| R-HSA-382551 | Transport of small molecules | 8.865731e-01 | 0.052 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.963175e-01 | 0.048 |
| R-HSA-1643685 | Disease | 8.977611e-01 | 0.047 |
| R-HSA-9658195 | Leishmania infection | 9.018145e-01 | 0.045 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.018145e-01 | 0.045 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.025758e-01 | 0.045 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.292252e-01 | 0.032 |
| R-HSA-1474244 | Extracellular matrix organization | 9.335101e-01 | 0.030 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.422331e-01 | 0.026 |
| R-HSA-388396 | GPCR downstream signalling | 9.454589e-01 | 0.024 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.486277e-01 | 0.023 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.560743e-01 | 0.020 |
| R-HSA-372790 | Signaling by GPCR | 9.665710e-01 | 0.015 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.750446e-01 | 0.011 |
| R-HSA-6798695 | Neutrophil degranulation | 9.754344e-01 | 0.011 |
| R-HSA-5663205 | Infectious disease | 9.805527e-01 | 0.009 |
| R-HSA-1266738 | Developmental Biology | 9.870810e-01 | 0.006 |
| R-HSA-9679506 | SARS-CoV Infections | 9.886699e-01 | 0.005 |
| R-HSA-168256 | Immune System | 9.937021e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.999239e-01 | 0.000 |
| R-HSA-168249 | Innate Immune System | 9.999790e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
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| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.850 | 0.168 | 2 | 0.866 |
CLK3 |
0.847 | 0.307 | 1 | 0.896 |
KIS |
0.844 | 0.354 | 1 | 0.872 |
GRK1 |
0.843 | 0.231 | -2 | 0.843 |
JNK3 |
0.838 | 0.396 | 1 | 0.851 |
JNK2 |
0.835 | 0.390 | 1 | 0.829 |
NLK |
0.834 | 0.252 | 1 | 0.905 |
MOS |
0.833 | 0.103 | 1 | 0.799 |
ERK5 |
0.832 | 0.190 | 1 | 0.834 |
PRPK |
0.831 | 0.043 | -1 | 0.804 |
IKKB |
0.831 | 0.027 | -2 | 0.777 |
CDK8 |
0.831 | 0.311 | 1 | 0.867 |
IKKA |
0.831 | 0.116 | -2 | 0.780 |
MTOR |
0.829 | 0.043 | 1 | 0.803 |
DYRK2 |
0.829 | 0.308 | 1 | 0.862 |
PIM3 |
0.828 | 0.067 | -3 | 0.752 |
P38G |
0.827 | 0.354 | 1 | 0.781 |
CDK1 |
0.827 | 0.320 | 1 | 0.833 |
CDC7 |
0.827 | 0.002 | 1 | 0.764 |
CDK19 |
0.826 | 0.312 | 1 | 0.846 |
SRPK1 |
0.825 | 0.153 | -3 | 0.667 |
CDK18 |
0.825 | 0.327 | 1 | 0.820 |
DSTYK |
0.824 | -0.017 | 2 | 0.873 |
P38B |
0.824 | 0.340 | 1 | 0.825 |
HIPK4 |
0.824 | 0.193 | 1 | 0.860 |
TBK1 |
0.823 | -0.031 | 1 | 0.689 |
CDK5 |
0.823 | 0.306 | 1 | 0.868 |
HIPK2 |
0.823 | 0.314 | 1 | 0.818 |
PRKD1 |
0.823 | 0.122 | -3 | 0.740 |
SKMLCK |
0.822 | 0.071 | -2 | 0.842 |
CAMK2G |
0.822 | -0.004 | 2 | 0.785 |
ERK1 |
0.822 | 0.318 | 1 | 0.825 |
IKKE |
0.822 | -0.032 | 1 | 0.688 |
P38D |
0.821 | 0.375 | 1 | 0.793 |
NDR2 |
0.821 | 0.059 | -3 | 0.753 |
BMPR1B |
0.821 | 0.139 | 1 | 0.725 |
BMPR2 |
0.821 | -0.094 | -2 | 0.882 |
CDKL1 |
0.821 | 0.033 | -3 | 0.707 |
CLK2 |
0.820 | 0.230 | -3 | 0.662 |
RAF1 |
0.820 | -0.111 | 1 | 0.770 |
CDK13 |
0.820 | 0.283 | 1 | 0.850 |
ATR |
0.820 | -0.013 | 1 | 0.744 |
DYRK4 |
0.820 | 0.325 | 1 | 0.832 |
CDK3 |
0.819 | 0.298 | 1 | 0.796 |
GRK7 |
0.819 | 0.118 | 1 | 0.719 |
GRK6 |
0.819 | 0.048 | 1 | 0.760 |
JNK1 |
0.819 | 0.340 | 1 | 0.817 |
GRK5 |
0.819 | -0.027 | -3 | 0.788 |
CDK17 |
0.818 | 0.318 | 1 | 0.782 |
CDK7 |
0.817 | 0.260 | 1 | 0.863 |
ICK |
0.817 | 0.116 | -3 | 0.747 |
P38A |
0.817 | 0.296 | 1 | 0.864 |
GCN2 |
0.816 | -0.152 | 2 | 0.768 |
HIPK1 |
0.816 | 0.279 | 1 | 0.878 |
PDHK4 |
0.816 | -0.223 | 1 | 0.801 |
MLK1 |
0.816 | -0.061 | 2 | 0.797 |
CAMK1B |
0.815 | -0.064 | -3 | 0.759 |
LATS1 |
0.814 | 0.145 | -3 | 0.768 |
TGFBR1 |
0.814 | 0.085 | -2 | 0.849 |
PIM1 |
0.813 | 0.054 | -3 | 0.701 |
CDK12 |
0.813 | 0.281 | 1 | 0.833 |
GRK4 |
0.813 | -0.015 | -2 | 0.854 |
RSK2 |
0.813 | 0.036 | -3 | 0.676 |
SRPK2 |
0.813 | 0.097 | -3 | 0.590 |
ULK2 |
0.813 | -0.171 | 2 | 0.763 |
PKN3 |
0.812 | -0.020 | -3 | 0.720 |
CDKL5 |
0.812 | 0.030 | -3 | 0.696 |
CHAK2 |
0.812 | -0.041 | -1 | 0.768 |
PRP4 |
0.812 | 0.190 | -3 | 0.715 |
TGFBR2 |
0.811 | -0.041 | -2 | 0.825 |
CDK16 |
0.811 | 0.310 | 1 | 0.796 |
NEK6 |
0.811 | -0.090 | -2 | 0.866 |
FAM20C |
0.811 | 0.056 | 2 | 0.609 |
ERK2 |
0.811 | 0.270 | 1 | 0.852 |
SRPK3 |
0.811 | 0.083 | -3 | 0.638 |
NEK7 |
0.811 | -0.144 | -3 | 0.781 |
CDK9 |
0.811 | 0.271 | 1 | 0.855 |
P90RSK |
0.811 | 0.032 | -3 | 0.681 |
RIPK3 |
0.810 | -0.107 | 3 | 0.738 |
NIK |
0.810 | -0.113 | -3 | 0.782 |
CAMK2B |
0.810 | 0.054 | 2 | 0.757 |
LATS2 |
0.810 | 0.028 | -5 | 0.662 |
MASTL |
0.810 | -0.103 | -2 | 0.817 |
DYRK1A |
0.810 | 0.227 | 1 | 0.883 |
CAMLCK |
0.809 | -0.049 | -2 | 0.816 |
ALK4 |
0.809 | 0.037 | -2 | 0.867 |
MARK4 |
0.809 | -0.030 | 4 | 0.718 |
NUAK2 |
0.809 | -0.015 | -3 | 0.742 |
CLK4 |
0.809 | 0.128 | -3 | 0.675 |
MAPKAPK2 |
0.809 | 0.028 | -3 | 0.656 |
HUNK |
0.809 | -0.083 | 2 | 0.807 |
MLK2 |
0.808 | -0.072 | 2 | 0.788 |
DLK |
0.808 | -0.112 | 1 | 0.766 |
CK1E |
0.808 | 0.107 | -3 | 0.611 |
CDK2 |
0.807 | 0.181 | 1 | 0.860 |
PRKD2 |
0.807 | 0.015 | -3 | 0.681 |
CAMK2D |
0.807 | -0.018 | -3 | 0.738 |
PDHK1 |
0.807 | -0.234 | 1 | 0.789 |
TSSK2 |
0.807 | 0.027 | -5 | 0.782 |
MLK3 |
0.807 | -0.029 | 2 | 0.732 |
DYRK1B |
0.807 | 0.265 | 1 | 0.849 |
CLK1 |
0.807 | 0.146 | -3 | 0.646 |
WNK1 |
0.806 | -0.101 | -2 | 0.857 |
ACVR2B |
0.806 | 0.046 | -2 | 0.834 |
DAPK2 |
0.806 | -0.079 | -3 | 0.765 |
PKCD |
0.806 | -0.024 | 2 | 0.778 |
TTBK2 |
0.805 | -0.101 | 2 | 0.688 |
CDK14 |
0.805 | 0.282 | 1 | 0.849 |
ALK2 |
0.805 | 0.080 | -2 | 0.855 |
NDR1 |
0.805 | -0.070 | -3 | 0.741 |
ATM |
0.805 | -0.037 | 1 | 0.678 |
GSK3A |
0.804 | 0.103 | 4 | 0.381 |
CAMK2A |
0.804 | 0.038 | 2 | 0.765 |
MLK4 |
0.804 | -0.037 | 2 | 0.717 |
PKN2 |
0.804 | -0.069 | -3 | 0.741 |
NEK9 |
0.803 | -0.142 | 2 | 0.808 |
YSK4 |
0.803 | -0.049 | 1 | 0.722 |
ACVR2A |
0.803 | 0.025 | -2 | 0.817 |
MAPKAPK3 |
0.803 | -0.046 | -3 | 0.688 |
ULK1 |
0.803 | -0.181 | -3 | 0.746 |
BCKDK |
0.803 | -0.150 | -1 | 0.705 |
RSK4 |
0.802 | 0.042 | -3 | 0.650 |
HIPK3 |
0.802 | 0.228 | 1 | 0.864 |
MST4 |
0.802 | -0.103 | 2 | 0.788 |
RSK3 |
0.802 | -0.039 | -3 | 0.668 |
PLK1 |
0.802 | -0.074 | -2 | 0.806 |
AMPKA1 |
0.802 | -0.075 | -3 | 0.755 |
TSSK1 |
0.801 | 0.011 | -3 | 0.768 |
GRK2 |
0.801 | 0.002 | -2 | 0.747 |
VRK2 |
0.800 | -0.056 | 1 | 0.832 |
CK1D |
0.800 | 0.108 | -3 | 0.569 |
PASK |
0.800 | 0.122 | -3 | 0.771 |
BMPR1A |
0.800 | 0.088 | 1 | 0.710 |
ANKRD3 |
0.799 | -0.201 | 1 | 0.775 |
MSK2 |
0.799 | -0.038 | -3 | 0.664 |
CDK10 |
0.798 | 0.258 | 1 | 0.839 |
PKACG |
0.798 | -0.064 | -2 | 0.690 |
PKR |
0.798 | -0.082 | 1 | 0.762 |
PLK3 |
0.798 | -0.034 | 2 | 0.751 |
P70S6KB |
0.798 | -0.081 | -3 | 0.693 |
MEK1 |
0.798 | -0.131 | 2 | 0.797 |
PKCB |
0.797 | -0.033 | 2 | 0.734 |
DYRK3 |
0.797 | 0.176 | 1 | 0.866 |
TLK2 |
0.796 | -0.076 | 1 | 0.710 |
WNK3 |
0.796 | -0.282 | 1 | 0.742 |
PAK1 |
0.796 | -0.071 | -2 | 0.733 |
AMPKA2 |
0.796 | -0.063 | -3 | 0.721 |
NIM1 |
0.795 | -0.118 | 3 | 0.757 |
MSK1 |
0.795 | -0.004 | -3 | 0.661 |
IRE1 |
0.794 | -0.139 | 1 | 0.717 |
ERK7 |
0.794 | 0.130 | 2 | 0.568 |
RIPK1 |
0.794 | -0.232 | 1 | 0.731 |
DNAPK |
0.794 | -0.013 | 1 | 0.633 |
SMG1 |
0.794 | -0.079 | 1 | 0.694 |
PKACB |
0.793 | -0.001 | -2 | 0.614 |
CK1A2 |
0.793 | 0.079 | -3 | 0.566 |
GSK3B |
0.793 | 0.011 | 4 | 0.365 |
MAK |
0.793 | 0.208 | -2 | 0.714 |
AURC |
0.792 | -0.030 | -2 | 0.600 |
IRE2 |
0.792 | -0.090 | 2 | 0.748 |
PKCG |
0.792 | -0.071 | 2 | 0.734 |
CK1G1 |
0.792 | 0.055 | -3 | 0.608 |
PKCA |
0.792 | -0.044 | 2 | 0.725 |
GRK3 |
0.791 | 0.015 | -2 | 0.715 |
MPSK1 |
0.791 | 0.078 | 1 | 0.754 |
PRKD3 |
0.791 | -0.049 | -3 | 0.648 |
QSK |
0.791 | -0.049 | 4 | 0.693 |
MNK1 |
0.791 | -0.024 | -2 | 0.752 |
GAK |
0.791 | 0.093 | 1 | 0.801 |
CDK6 |
0.790 | 0.255 | 1 | 0.838 |
PKCZ |
0.790 | -0.082 | 2 | 0.767 |
MEKK2 |
0.790 | -0.089 | 2 | 0.780 |
MEKK3 |
0.790 | -0.121 | 1 | 0.740 |
PAK3 |
0.790 | -0.122 | -2 | 0.732 |
BRAF |
0.789 | -0.110 | -4 | 0.820 |
MARK3 |
0.789 | -0.035 | 4 | 0.659 |
TAO3 |
0.788 | -0.064 | 1 | 0.746 |
CAMK4 |
0.788 | -0.157 | -3 | 0.717 |
MEKK1 |
0.788 | -0.126 | 1 | 0.754 |
SGK3 |
0.788 | -0.038 | -3 | 0.663 |
MARK2 |
0.787 | -0.054 | 4 | 0.629 |
PRKX |
0.787 | 0.010 | -3 | 0.595 |
BRSK1 |
0.787 | -0.069 | -3 | 0.692 |
CHK1 |
0.787 | -0.048 | -3 | 0.724 |
MNK2 |
0.787 | -0.092 | -2 | 0.741 |
CK2A2 |
0.787 | 0.059 | 1 | 0.607 |
CHAK1 |
0.787 | -0.169 | 2 | 0.724 |
NEK2 |
0.787 | -0.155 | 2 | 0.779 |
MST3 |
0.786 | -0.054 | 2 | 0.805 |
ZAK |
0.786 | -0.142 | 1 | 0.735 |
NEK5 |
0.786 | -0.119 | 1 | 0.746 |
NUAK1 |
0.786 | -0.081 | -3 | 0.683 |
MYLK4 |
0.786 | -0.075 | -2 | 0.731 |
SIK |
0.786 | -0.080 | -3 | 0.667 |
MEK5 |
0.786 | -0.223 | 2 | 0.787 |
MELK |
0.786 | -0.122 | -3 | 0.699 |
PKCH |
0.785 | -0.097 | 2 | 0.724 |
PERK |
0.785 | -0.157 | -2 | 0.859 |
PLK4 |
0.785 | -0.146 | 2 | 0.611 |
CDK4 |
0.785 | 0.246 | 1 | 0.824 |
PLK2 |
0.785 | 0.029 | -3 | 0.736 |
AKT2 |
0.784 | -0.036 | -3 | 0.595 |
PIM2 |
0.784 | -0.023 | -3 | 0.643 |
DRAK1 |
0.784 | -0.121 | 1 | 0.657 |
PINK1 |
0.784 | -0.105 | 1 | 0.832 |
PHKG1 |
0.784 | -0.129 | -3 | 0.736 |
QIK |
0.784 | -0.173 | -3 | 0.727 |
DCAMKL1 |
0.784 | -0.065 | -3 | 0.699 |
PKG2 |
0.784 | -0.049 | -2 | 0.611 |
SSTK |
0.782 | -0.011 | 4 | 0.670 |
PAK2 |
0.782 | -0.133 | -2 | 0.720 |
BRSK2 |
0.781 | -0.117 | -3 | 0.709 |
AURB |
0.780 | -0.069 | -2 | 0.595 |
MST2 |
0.780 | -0.074 | 1 | 0.741 |
TLK1 |
0.779 | -0.152 | -2 | 0.861 |
MARK1 |
0.779 | -0.096 | 4 | 0.677 |
IRAK4 |
0.779 | -0.155 | 1 | 0.724 |
AURA |
0.779 | -0.062 | -2 | 0.572 |
HRI |
0.778 | -0.231 | -2 | 0.853 |
GCK |
0.778 | -0.040 | 1 | 0.735 |
PAK6 |
0.778 | -0.069 | -2 | 0.656 |
MAP3K15 |
0.777 | -0.053 | 1 | 0.724 |
NEK11 |
0.777 | -0.165 | 1 | 0.735 |
CK2A1 |
0.777 | 0.034 | 1 | 0.583 |
PDK1 |
0.777 | -0.080 | 1 | 0.732 |
MAPKAPK5 |
0.776 | -0.151 | -3 | 0.628 |
CAMKK1 |
0.776 | -0.164 | -2 | 0.775 |
MOK |
0.775 | 0.140 | 1 | 0.838 |
WNK4 |
0.775 | -0.198 | -2 | 0.850 |
CAMK1G |
0.775 | -0.112 | -3 | 0.657 |
TAK1 |
0.775 | -0.083 | 1 | 0.740 |
TAO2 |
0.774 | -0.138 | 2 | 0.823 |
SMMLCK |
0.774 | -0.107 | -3 | 0.708 |
SNRK |
0.774 | -0.229 | 2 | 0.668 |
VRK1 |
0.774 | -0.083 | 2 | 0.840 |
PKACA |
0.774 | -0.032 | -2 | 0.559 |
NEK8 |
0.773 | -0.205 | 2 | 0.799 |
PKCT |
0.773 | -0.106 | 2 | 0.727 |
DCAMKL2 |
0.773 | -0.106 | -3 | 0.710 |
LKB1 |
0.773 | -0.127 | -3 | 0.753 |
TTBK1 |
0.773 | -0.161 | 2 | 0.612 |
AKT1 |
0.772 | -0.052 | -3 | 0.614 |
EEF2K |
0.772 | -0.068 | 3 | 0.782 |
TNIK |
0.771 | -0.073 | 3 | 0.810 |
MINK |
0.771 | -0.103 | 1 | 0.729 |
MEKK6 |
0.771 | -0.131 | 1 | 0.745 |
CAMKK2 |
0.770 | -0.183 | -2 | 0.767 |
DAPK3 |
0.769 | -0.070 | -3 | 0.708 |
HGK |
0.769 | -0.108 | 3 | 0.815 |
LRRK2 |
0.769 | -0.135 | 2 | 0.816 |
KHS1 |
0.768 | -0.025 | 1 | 0.724 |
NEK4 |
0.768 | -0.176 | 1 | 0.721 |
HPK1 |
0.768 | -0.096 | 1 | 0.725 |
MST1 |
0.766 | -0.111 | 1 | 0.723 |
IRAK1 |
0.766 | -0.258 | -1 | 0.664 |
P70S6K |
0.766 | -0.110 | -3 | 0.602 |
SGK1 |
0.765 | -0.023 | -3 | 0.527 |
CAMK1D |
0.765 | -0.080 | -3 | 0.584 |
PKCE |
0.765 | -0.070 | 2 | 0.721 |
SBK |
0.764 | 0.019 | -3 | 0.489 |
CK1A |
0.764 | 0.061 | -3 | 0.500 |
PKCI |
0.763 | -0.124 | 2 | 0.734 |
DAPK1 |
0.763 | -0.074 | -3 | 0.688 |
TTK |
0.763 | -0.033 | -2 | 0.829 |
NEK1 |
0.762 | -0.169 | 1 | 0.726 |
KHS2 |
0.762 | -0.054 | 1 | 0.732 |
PHKG2 |
0.762 | -0.158 | -3 | 0.687 |
SLK |
0.762 | -0.109 | -2 | 0.716 |
ROCK2 |
0.761 | -0.049 | -3 | 0.690 |
AKT3 |
0.761 | -0.044 | -3 | 0.551 |
PAK5 |
0.760 | -0.109 | -2 | 0.592 |
PBK |
0.760 | -0.028 | 1 | 0.730 |
CHK2 |
0.760 | -0.071 | -3 | 0.548 |
YANK3 |
0.760 | -0.018 | 2 | 0.392 |
ALPHAK3 |
0.759 | -0.004 | -1 | 0.714 |
LOK |
0.759 | -0.153 | -2 | 0.750 |
OSR1 |
0.759 | -0.101 | 2 | 0.755 |
PAK4 |
0.759 | -0.089 | -2 | 0.595 |
BUB1 |
0.757 | -0.032 | -5 | 0.693 |
PKN1 |
0.757 | -0.088 | -3 | 0.621 |
STK33 |
0.756 | -0.184 | 2 | 0.598 |
PDHK3_TYR |
0.755 | 0.258 | 4 | 0.787 |
ASK1 |
0.755 | -0.086 | 1 | 0.719 |
YSK1 |
0.755 | -0.160 | 2 | 0.774 |
DMPK1 |
0.754 | -0.022 | -3 | 0.662 |
BIKE |
0.754 | 0.026 | 1 | 0.711 |
HASPIN |
0.754 | -0.051 | -1 | 0.623 |
MRCKB |
0.754 | -0.087 | -3 | 0.630 |
MEK2 |
0.753 | -0.272 | 2 | 0.763 |
CAMK1A |
0.752 | -0.083 | -3 | 0.570 |
MRCKA |
0.752 | -0.094 | -3 | 0.652 |
PDHK4_TYR |
0.749 | 0.148 | 2 | 0.834 |
RIPK2 |
0.749 | -0.287 | 1 | 0.683 |
MAP2K6_TYR |
0.745 | 0.083 | -1 | 0.797 |
AAK1 |
0.745 | 0.096 | 1 | 0.631 |
MYO3B |
0.744 | -0.129 | 2 | 0.778 |
MYO3A |
0.744 | -0.140 | 1 | 0.724 |
PDHK1_TYR |
0.743 | 0.046 | -1 | 0.804 |
ROCK1 |
0.743 | -0.088 | -3 | 0.651 |
BMPR2_TYR |
0.743 | 0.021 | -1 | 0.788 |
MAP2K4_TYR |
0.742 | -0.019 | -1 | 0.796 |
NEK3 |
0.741 | -0.249 | 1 | 0.715 |
PKMYT1_TYR |
0.740 | 0.023 | 3 | 0.827 |
CK1G3 |
0.740 | 0.030 | -3 | 0.457 |
TESK1_TYR |
0.740 | -0.045 | 3 | 0.855 |
CRIK |
0.740 | -0.066 | -3 | 0.615 |
TAO1 |
0.740 | -0.167 | 1 | 0.686 |
STLK3 |
0.739 | -0.175 | 1 | 0.697 |
MAP2K7_TYR |
0.738 | -0.130 | 2 | 0.821 |
PKG1 |
0.738 | -0.106 | -2 | 0.515 |
TXK |
0.734 | 0.044 | 1 | 0.730 |
PINK1_TYR |
0.733 | -0.184 | 1 | 0.782 |
EPHA6 |
0.732 | -0.034 | -1 | 0.769 |
LIMK2_TYR |
0.732 | -0.050 | -3 | 0.793 |
CK1G2 |
0.731 | 0.035 | -3 | 0.536 |
YES1 |
0.731 | 0.009 | -1 | 0.782 |
EPHB4 |
0.731 | -0.041 | -1 | 0.748 |
CSF1R |
0.730 | -0.037 | 3 | 0.741 |
FGR |
0.729 | 0.011 | 1 | 0.759 |
YANK2 |
0.729 | -0.045 | 2 | 0.413 |
FER |
0.729 | -0.026 | 1 | 0.776 |
RET |
0.729 | -0.140 | 1 | 0.751 |
ROS1 |
0.728 | -0.063 | 3 | 0.735 |
JAK2 |
0.727 | -0.081 | 1 | 0.755 |
ABL2 |
0.727 | -0.051 | -1 | 0.727 |
INSRR |
0.726 | -0.041 | 3 | 0.716 |
FYN |
0.726 | 0.061 | -1 | 0.771 |
TYRO3 |
0.726 | -0.135 | 3 | 0.755 |
TYK2 |
0.726 | -0.143 | 1 | 0.748 |
LCK |
0.725 | -0.007 | -1 | 0.766 |
MST1R |
0.725 | -0.168 | 3 | 0.768 |
SRMS |
0.724 | -0.034 | 1 | 0.756 |
BLK |
0.724 | 0.024 | -1 | 0.758 |
ITK |
0.724 | -0.047 | -1 | 0.725 |
HCK |
0.724 | -0.052 | -1 | 0.759 |
EPHA4 |
0.724 | -0.023 | 2 | 0.757 |
LIMK1_TYR |
0.723 | -0.202 | 2 | 0.816 |
ABL1 |
0.723 | -0.074 | -1 | 0.718 |
KIT |
0.722 | -0.072 | 3 | 0.747 |
JAK3 |
0.722 | -0.128 | 1 | 0.734 |
BMX |
0.722 | -0.015 | -1 | 0.686 |
FGFR2 |
0.721 | -0.094 | 3 | 0.772 |
DDR1 |
0.721 | -0.159 | 4 | 0.690 |
EPHB2 |
0.720 | -0.052 | -1 | 0.721 |
EPHB1 |
0.719 | -0.093 | 1 | 0.758 |
MERTK |
0.718 | -0.068 | 3 | 0.740 |
TNK2 |
0.718 | -0.093 | 3 | 0.719 |
EPHB3 |
0.718 | -0.083 | -1 | 0.732 |
KDR |
0.716 | -0.116 | 3 | 0.709 |
TEK |
0.716 | -0.104 | 3 | 0.699 |
MET |
0.716 | -0.094 | 3 | 0.737 |
JAK1 |
0.715 | -0.050 | 1 | 0.702 |
FGFR3 |
0.715 | -0.079 | 3 | 0.741 |
FLT3 |
0.715 | -0.161 | 3 | 0.742 |
FGFR1 |
0.714 | -0.130 | 3 | 0.734 |
TEC |
0.714 | -0.095 | -1 | 0.679 |
SRC |
0.713 | -0.014 | -1 | 0.758 |
PDGFRB |
0.713 | -0.193 | 3 | 0.755 |
AXL |
0.713 | -0.142 | 3 | 0.749 |
TNK1 |
0.712 | -0.119 | 3 | 0.739 |
FLT1 |
0.712 | -0.115 | -1 | 0.733 |
BTK |
0.712 | -0.172 | -1 | 0.700 |
SYK |
0.711 | 0.035 | -1 | 0.712 |
NTRK1 |
0.711 | -0.130 | -1 | 0.749 |
EGFR |
0.711 | -0.040 | 1 | 0.630 |
LYN |
0.711 | -0.071 | 3 | 0.682 |
ERBB2 |
0.710 | -0.139 | 1 | 0.709 |
NEK10_TYR |
0.710 | -0.157 | 1 | 0.661 |
EPHA7 |
0.710 | -0.090 | 2 | 0.764 |
TNNI3K_TYR |
0.709 | -0.087 | 1 | 0.761 |
WEE1_TYR |
0.708 | -0.124 | -1 | 0.714 |
INSR |
0.708 | -0.119 | 3 | 0.701 |
NTRK3 |
0.708 | -0.085 | -1 | 0.722 |
ALK |
0.707 | -0.145 | 3 | 0.665 |
MATK |
0.707 | -0.085 | -1 | 0.665 |
FGFR4 |
0.707 | -0.048 | -1 | 0.691 |
FRK |
0.707 | -0.121 | -1 | 0.748 |
DDR2 |
0.707 | -0.025 | 3 | 0.702 |
PTK6 |
0.707 | -0.187 | -1 | 0.678 |
EPHA5 |
0.706 | -0.073 | 2 | 0.754 |
EPHA3 |
0.706 | -0.141 | 2 | 0.734 |
PTK2 |
0.706 | -0.002 | -1 | 0.707 |
LTK |
0.705 | -0.157 | 3 | 0.693 |
NTRK2 |
0.704 | -0.189 | 3 | 0.717 |
PTK2B |
0.704 | -0.095 | -1 | 0.703 |
EPHA8 |
0.703 | -0.086 | -1 | 0.727 |
FLT4 |
0.703 | -0.184 | 3 | 0.722 |
EPHA1 |
0.702 | -0.163 | 3 | 0.715 |
PDGFRA |
0.702 | -0.265 | 3 | 0.744 |
CSK |
0.701 | -0.122 | 2 | 0.759 |
IGF1R |
0.699 | -0.078 | 3 | 0.646 |
ERBB4 |
0.699 | -0.037 | 1 | 0.641 |
EPHA2 |
0.695 | -0.084 | -1 | 0.691 |
ZAP70 |
0.694 | 0.003 | -1 | 0.664 |
MUSK |
0.686 | -0.173 | 1 | 0.618 |
FES |
0.683 | -0.114 | -1 | 0.668 |