Motif 447 (n=112)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0C4DFX4 None S243 ochoa Snf2 related CREBBP activator protein None
A1L390 PLEKHG3 S647 ochoa Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
A6NKT7 RGPD3 S768 ochoa RanBP2-like and GRIP domain-containing protein 3 None
M0QYT0 None S206 ochoa RRM domain-containing protein None
O14715 RGPD8 S767 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O14795 UNC13B S231 ochoa Protein unc-13 homolog B (Munc13-2) (munc13) Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}.
O15047 SETD1A S468 ochoa Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}.
O43683 BUB1 S198 psp Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O60237 PPP1R12B S447 ochoa Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
O60292 SIPA1L3 S1306 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O95644 NFATC1 S176 ochoa Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
O96020 CCNE2 S67 ochoa G1/S-specific cyclin-E2 Essential for the control of the cell cycle at the late G1 and early S phase. {ECO:0000269|PubMed:9840927, ECO:0000269|PubMed:9840943, ECO:0000269|PubMed:9858585}.
P0DJD0 RGPD1 S758 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S766 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P10606 COX5B S84 ochoa Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04037}.
P11474 ESRRA S26 ochoa Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. {ECO:0000269|PubMed:12522104, ECO:0000269|PubMed:16150865, ECO:0000269|PubMed:17676930, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:9271417}.
P13994 YJU2B S366 ochoa Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}.
P15391 CD19 S342 ochoa B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19) Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126). {ECO:0000250|UniProtKB:P25918, ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}.
P16066 NPR1 S538 psp Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}.
P20393 NR1D1 S59 psp Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}.
P29374 ARID4A S676 ochoa AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.
P35568 IRS1 S374 ochoa Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P36871 PGM1 S509 ochoa Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}.
P39880 CUX1 S875 ochoa Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
P40692 MLH1 S405 ochoa DNA mismatch repair protein Mlh1 (MutL protein homolog 1) Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:20020535, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:9311737}.
P45974 USP5 S710 ochoa Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}.
P48634 PRRC2A S2073 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P48681 NES S475 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P48681 NES S1445 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P49792 RANBP2 S767 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P51784 USP11 S942 ochoa Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799, PubMed:28992046). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046). {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726, ECO:0000269|PubMed:24724799, ECO:0000269|PubMed:28992046}.
P54132 BLM S579 ochoa RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}.
P54252 ATXN3 S260 psp Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}.
P78347 GTF2I S214 ochoa General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
Q01974 ROR2 S576 ochoa Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}.
Q05209 PTPN12 S555 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q08380 LGALS3BP S444 ochoa Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K) Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. {ECO:0000269|PubMed:11146440, ECO:0000269|PubMed:8034587, ECO:0000269|PubMed:9501082}.
Q13011 ECH1 S36 ochoa Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}.
Q13177 PAK2 S36 ochoa Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}.
Q14126 DSG2 S1059 ochoa Desmoglein-2 (Cadherin family member 5) (HDGC) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}.
Q14157 UBAP2L S319 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14185 DOCK1 S1807 ochoa Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}.
Q14699 RFTN1 S238 ochoa Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
Q15139 PRKD1 S548 ochoa Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}.
Q15583 TGIF1 S290 ochoa Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Q15714 TSC22D1 S267 ochoa TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}.
Q15811 ITSN1 S203 ochoa Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}.
Q16512 PKN1 S380 ochoa Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}.
Q17R98 ZNF827 S246 ochoa Zinc finger protein 827 As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}.
Q2M1V0 ISX S183 psp Intestine-specific homeobox (RAX-like homeobox) Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity). {ECO:0000250}.
Q2TAZ0 ATG2A S1402 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q58EX2 SDK2 S2105 ochoa Protein sidekick-2 Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}.
Q5M775 SPECC1 S314 ochoa Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) None
Q5SNT2 TMEM201 S473 ochoa Transmembrane protein 201 (Spindle-associated membrane protein 1) Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
Q5VST9 OBSCN S6961 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q68CZ2 TNS3 S976 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q68DK2 ZFYVE26 S1275 ochoa Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}.
Q6PJ69 TRIM65 S167 psp E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65) E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (PubMed:24778252). This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (PubMed:31160576). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade (PubMed:28594402). Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (PubMed:33373584). Plays also a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673). {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:31160576, ECO:0000269|PubMed:31310649, ECO:0000269|PubMed:33373584, ECO:0000269|PubMed:34512673}.
Q6ZRS2 SRCAP S262 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q6ZSZ5 ARHGEF18 S71 ochoa Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}.
Q7L4E1 MIGA2 S228 ochoa Mitoguardin 2 (Protein FAM73B) Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}.
Q7Z3J3 RGPD4 S768 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z589 EMSY S1101 ochoa BRCA2-interacting transcriptional repressor EMSY Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.
Q7Z5J4 RAI1 S1362 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q86UU0 BCL9L S1458 ochoa B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86UU1 PHLDB1 S465 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q8IV36 HID1 S593 ochoa Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}.
Q8IX90 SKA3 S317 ochoa Spindle and kinetochore-associated protein 3 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}.
Q8N2G6 ZCCHC24 S97 ochoa Zinc finger CCHC domain-containing protein 24 None
Q8ND83 SLAIN1 S247 ochoa SLAIN motif-containing protein 1 Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. {ECO:0000269|PubMed:21646404}.
Q8NEM0 MCPH1 S337 ochoa Microcephalin Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}.
Q8NFP9 NBEA S1011 ochoa Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}.
Q8TAP8 PPP1R35 S91 ochoa Protein phosphatase 1 regulatory subunit 35 During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}.
Q8TDD2 SP7 S80 psp Transcription factor Sp7 (Zinc finger protein osterix) Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). {ECO:0000250|UniProtKB:Q8VI67, ECO:0000269|PubMed:23457570}.
Q96BY6 DOCK10 S1322 ochoa Dedicator of cytokinesis protein 10 (Zizimin-3) Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.
Q96GS4 BORCS6 S93 ochoa BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}.
Q96MK2 RIPOR3 S603 ochoa RIPOR family member 3 None
Q96T37 RBM15 S212 ochoa RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q99638 RAD9A S270 ochoa Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}.
Q99666 RGPD5 S767 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9BQ52 ELAC2 S212 ochoa Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}.
Q9BX66 SORBS1 S280 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9C0B0 UNK S474 psp RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9H1Z4 WDR13 S74 ochoa WD repeat-containing protein 13 None
Q9H3M0 KCNF1 S177 ochoa Voltage-gated potassium channel regulatory subunit KCNF1 (Potassium voltage-gated channel subfamily F member 1) (Voltage-gated potassium channel subunit Kv5.1) (kH1) Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone. {ECO:0000250|UniProtKB:D4ADX7}.
Q9H4L5 OSBPL3 S197 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9H8N7 ZNF395 S376 ochoa Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) Plays a role in papillomavirus genes transcription.
Q9H9C1 VIPAS39 S130 ochoa Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}.
Q9NPI6 DCP1A S194 ochoa mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}.
Q9NQ31 AKIP1 S150 ochoa A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3) Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. {ECO:0000269|PubMed:18178962, ECO:0000269|PubMed:20562110}.
Q9NRL3 STRN4 S634 ochoa Striatin-4 (Zinedin) Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}.
Q9NZC9 SMARCAL1 S172 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}.
Q9NZT2 OGFR S382 ochoa Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Q9P206 NHSL3 S284 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P206 NHSL3 S508 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P270 SLAIN2 S251 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9P2N6 KANSL3 S880 ochoa KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q9UHB7 AFF4 S409 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UK58 CCNL1 S69 ochoa Cyclin-L1 (Cyclin-L) Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}.
Q9UK61 TASOR S1107 ochoa Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q9UKK3 PARP4 S1292 ochoa Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q9ULJ7 ANKRD50 S1352 ochoa Ankyrin repeat domain-containing protein 50 Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Q9UPW5 AGTPBP1 S319 ochoa Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1) Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000269|PubMed:22170066, ECO:0000269|PubMed:24022482, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:30420557}.
Q9UQ35 SRRM2 S2141 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2X7 GIT1 S592 ochoa ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y5Y4 PTGDR2 S338 ochoa Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
O60563 CCNT1 S369 Sugiyama Cyclin-T1 (CycT1) (Cyclin-T) Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}.
Q9HBL0 TNS1 S858 Sugiyama Tensin-1 (EC 3.1.3.-) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}.
Q06187 BTK S557 Sugiyama Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}.
Q16539 MAPK14 S32 Sugiyama Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:9430721, PubMed:9858528). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}.
P18850 ATF6 S98 Sugiyama Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}.
Q9UHD2 TBK1 S531 Sugiyama Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}.
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reactome_id name p -log10_p
R-HSA-69620 Cell Cycle Checkpoints 0.001198 2.922
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.003158 2.501
R-HSA-9008059 Interleukin-37 signaling 0.002582 2.588
R-HSA-5689877 Josephin domain DUBs 0.004368 2.360
R-HSA-416482 G alpha (12/13) signalling events 0.004088 2.388
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.014794 1.830
R-HSA-5632987 Defective Mismatch Repair Associated With PMS2 0.014794 1.830
R-HSA-5545483 Defective Mismatch Repair Associated With MLH1 0.014794 1.830
R-HSA-176034 Interactions of Tat with host cellular proteins 0.022110 1.655
R-HSA-5609974 Defective PGM1 causes PGM1-CDG 0.022110 1.655
R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.029372 1.532
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.043735 1.359
R-HSA-74713 IRS activation 0.050838 1.294
R-HSA-112412 SOS-mediated signalling 0.071833 1.144
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.092367 1.034
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.105806 0.975
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.105806 0.975
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.119047 0.924
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.119047 0.924
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.028478 1.545
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.132094 0.879
R-HSA-8964315 G beta:gamma signalling through BTK 0.132094 0.879
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.144949 0.839
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.163879 0.785
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.170096 0.769
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.170096 0.769
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.170096 0.769
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.170096 0.769
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.176267 0.754
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.176267 0.754
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.182393 0.739
R-HSA-112382 Formation of RNA Pol II elongation complex 0.074319 1.129
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.206447 0.685
R-HSA-141424 Amplification of signal from the kinetochores 0.033738 1.472
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.033738 1.472
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.218210 0.661
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.218210 0.661
R-HSA-167287 HIV elongation arrest and recovery 0.224026 0.650
R-HSA-167290 Pausing and recovery of HIV elongation 0.224026 0.650
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.235531 0.628
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.241219 0.618
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.241219 0.618
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.241219 0.618
R-HSA-1855170 IPs transport between nucleus and cytosol 0.252471 0.598
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.252471 0.598
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.258034 0.588
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.269038 0.570
R-HSA-383280 Nuclear Receptor transcription pathway 0.135209 0.869
R-HSA-68962 Activation of the pre-replicative complex 0.235531 0.628
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.263556 0.579
R-HSA-69618 Mitotic Spindle Checkpoint 0.050801 1.294
R-HSA-198203 PI3K/AKT activation 0.092367 1.034
R-HSA-169911 Regulation of Apoptosis 0.269038 0.570
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.144949 0.839
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.046676 1.331
R-HSA-5693537 Resolution of D-Loop Structures 0.258034 0.588
R-HSA-1606341 IRF3 mediated activation of type 1 IFN 0.050838 1.294
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.078728 1.104
R-HSA-2025928 Calcineurin activates NFAT 0.085573 1.068
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.105806 0.975
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.034689 1.460
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.144949 0.839
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.252471 0.598
R-HSA-3928664 Ephrin signaling 0.013028 1.885
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.249953 0.602
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.076456 1.117
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.132094 0.879
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.182393 0.739
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.108232 0.966
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.029985 1.523
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.037974 1.421
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.241708 0.617
R-HSA-5358508 Mismatch Repair 0.157616 0.802
R-HSA-373756 SDK interactions 0.014794 1.830
R-HSA-3249367 STAT6-mediated induction of chemokines 0.036580 1.437
R-HSA-8875513 MET interacts with TNS proteins 0.036580 1.437
R-HSA-176974 Unwinding of DNA 0.085573 1.068
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 0.092367 1.034
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.119047 0.924
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.132094 0.879
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.036317 1.440
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.037974 1.421
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.151306 0.820
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.157616 0.802
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.157616 0.802
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.181992 0.740
R-HSA-5693538 Homology Directed Repair 0.258206 0.588
R-HSA-5693607 Processing of DNA double-strand break ends 0.142809 0.845
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.144949 0.839
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 0.144949 0.839
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.151306 0.820
R-HSA-74749 Signal attenuation 0.092367 1.034
R-HSA-418885 DCC mediated attractive signaling 0.132094 0.879
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.125228 0.902
R-HSA-9603381 Activated NTRK3 signals through PI3K 0.071833 1.144
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.105806 0.975
R-HSA-171007 p38MAPK events 0.132094 0.879
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.144949 0.839
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.044882 1.348
R-HSA-9707616 Heme signaling 0.015822 1.801
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.188474 0.725
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.258034 0.588
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.157616 0.802
R-HSA-525793 Myogenesis 0.212351 0.673
R-HSA-2424491 DAP12 signaling 0.235531 0.628
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.179329 0.746
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 0.036580 1.437
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 0.085573 1.068
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.125595 0.901
R-HSA-176187 Activation of ATR in response to replication stress 0.034689 1.460
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.144949 0.839
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.176267 0.754
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.176267 0.754
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.200500 0.698
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.235531 0.628
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.235531 0.628
R-HSA-1834941 STING mediated induction of host immune responses 0.163879 0.785
R-HSA-445355 Smooth Muscle Contraction 0.076456 1.117
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.224026 0.650
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.080636 1.093
R-HSA-9842663 Signaling by LTK 0.112451 0.949
R-HSA-69052 Switching of origins to a post-replicative state 0.122761 0.911
R-HSA-9837999 Mitochondrial protein degradation 0.181992 0.740
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.026952 1.569
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.039660 1.402
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.200500 0.698
R-HSA-6784531 tRNA processing in the nucleus 0.096513 1.015
R-HSA-180746 Nuclear import of Rev protein 0.263556 0.579
R-HSA-1839124 FGFR1 mutant receptor activation 0.252471 0.598
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.260959 0.583
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.260959 0.583
R-HSA-9708296 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 0.029372 1.532
R-HSA-428540 Activation of RAC1 0.105806 0.975
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.132094 0.879
R-HSA-9945266 Differentiation of T cells 0.138546 0.858
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 0.138546 0.858
R-HSA-163615 PKA activation 0.157616 0.802
R-HSA-1482801 Acyl chain remodelling of PS 0.206447 0.685
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.212351 0.673
R-HSA-2467813 Separation of Sister Chromatids 0.155163 0.809
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.144675 0.840
R-HSA-9909396 Circadian clock 0.099329 1.003
R-HSA-68877 Mitotic Prometaphase 0.210720 0.676
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.127759 0.894
R-HSA-432142 Platelet sensitization by LDL 0.157616 0.802
R-HSA-1482788 Acyl chain remodelling of PC 0.258034 0.588
R-HSA-1482839 Acyl chain remodelling of PE 0.269038 0.570
R-HSA-5205647 Mitophagy 0.263556 0.579
R-HSA-2682334 EPH-Ephrin signaling 0.041327 1.384
R-HSA-9675135 Diseases of DNA repair 0.007911 2.102
R-HSA-164944 Nef and signal transduction 0.064886 1.188
R-HSA-450341 Activation of the AP-1 family of transcription factors 0.085573 1.068
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.138546 0.858
R-HSA-167044 Signalling to RAS 0.176267 0.754
R-HSA-912446 Meiotic recombination 0.072202 1.141
R-HSA-9675126 Diseases of mitotic cell cycle 0.246866 0.608
R-HSA-397795 G-protein beta:gamma signalling 0.252471 0.598
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.062451 1.204
R-HSA-1592230 Mitochondrial biogenesis 0.017083 1.767
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.029401 1.532
R-HSA-69239 Synthesis of DNA 0.222533 0.653
R-HSA-389359 CD28 dependent Vav1 pathway 0.119047 0.924
R-HSA-5578768 Physiological factors 0.125595 0.901
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.132094 0.879
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.039660 1.402
R-HSA-70370 Galactose catabolism 0.144949 0.839
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.151306 0.820
R-HSA-69481 G2/M Checkpoints 0.090496 1.043
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.230143 0.638
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.072584 1.139
R-HSA-1538133 G0 and Early G1 0.246866 0.608
R-HSA-162909 Host Interactions of HIV factors 0.084801 1.072
R-HSA-168898 Toll-like Receptor Cascades 0.206880 0.684
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.230738 0.637
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.071833 1.144
R-HSA-193648 NRAGE signals death through JNK 0.012485 1.904
R-HSA-198753 ERK/MAPK targets 0.176267 0.754
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.176267 0.754
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.218210 0.661
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.224026 0.650
R-HSA-166166 MyD88-independent TLR4 cascade 0.230738 0.637
R-HSA-194138 Signaling by VEGF 0.087629 1.057
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.217076 0.663
R-HSA-69278 Cell Cycle, Mitotic 0.149458 0.825
R-HSA-69190 DNA strand elongation 0.246866 0.608
R-HSA-1640170 Cell Cycle 0.020603 1.686
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.112451 0.949
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.218210 0.661
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.229800 0.639
R-HSA-1500620 Meiosis 0.153079 0.815
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.120307 0.920
R-HSA-397014 Muscle contraction 0.249888 0.602
R-HSA-9662834 CD163 mediating an anti-inflammatory response 0.099111 1.004
R-HSA-391908 Prostanoid ligand receptors 0.099111 1.004
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.024150 1.617
R-HSA-9683610 Maturation of nucleoprotein 0.119047 0.924
R-HSA-5635838 Activation of SMO 0.138546 0.858
R-HSA-2586552 Signaling by Leptin 0.092367 1.034
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.182393 0.739
R-HSA-392518 Signal amplification 0.263556 0.579
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.078728 1.104
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.200500 0.698
R-HSA-381042 PERK regulates gene expression 0.269038 0.570
R-HSA-5688426 Deubiquitination 0.150357 0.823
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.047535 1.323
R-HSA-68875 Mitotic Prophase 0.263711 0.579
R-HSA-75153 Apoptotic execution phase 0.061928 1.208
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.043114 1.365
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.224026 0.650
R-HSA-69473 G2/M DNA damage checkpoint 0.125228 0.902
R-HSA-9679191 Potential therapeutics for SARS 0.131083 0.882
R-HSA-1852241 Organelle biogenesis and maintenance 0.248563 0.605
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.034643 1.460
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.241219 0.618
R-HSA-9694631 Maturation of nucleoprotein 0.163879 0.785
R-HSA-8863795 Downregulation of ERBB2 signaling 0.235531 0.628
R-HSA-391903 Eicosanoid ligand-binding receptors 0.170096 0.769
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.222533 0.653
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.206447 0.685
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 0.252471 0.598
R-HSA-187687 Signalling to ERKs 0.269038 0.570
R-HSA-68882 Mitotic Anaphase 0.257859 0.589
R-HSA-8878166 Transcriptional regulation by RUNX2 0.260959 0.583
R-HSA-9006936 Signaling by TGFB family members 0.148144 0.829
R-HSA-69615 G1/S DNA Damage Checkpoints 0.098826 1.005
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.259858 0.585
R-HSA-74160 Gene expression (Transcription) 0.154155 0.812
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.138546 0.858
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.023123 1.636
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.082981 1.081
R-HSA-162582 Signal Transduction 0.091756 1.037
R-HSA-9700206 Signaling by ALK in cancer 0.222533 0.653
R-HSA-168638 NOD1/2 Signaling Pathway 0.263556 0.579
R-HSA-390466 Chaperonin-mediated protein folding 0.160874 0.794
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.194509 0.711
R-HSA-211000 Gene Silencing by RNA 0.222533 0.653
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.258206 0.588
R-HSA-3322077 Glycogen synthesis 0.170096 0.769
R-HSA-182971 EGFR downregulation 0.241219 0.618
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.206203 0.686
R-HSA-1266695 Interleukin-7 signaling 0.206447 0.685
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.246866 0.608
R-HSA-982772 Growth hormone receptor signaling 0.194509 0.711
R-HSA-391251 Protein folding 0.176672 0.753
R-HSA-3700989 Transcriptional Regulation by TP53 0.029501 1.530
R-HSA-73887 Death Receptor Signaling 0.040397 1.394
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.103500 0.985
R-HSA-9856651 MITF-M-dependent gene expression 0.131083 0.882
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.246866 0.608
R-HSA-446652 Interleukin-1 family signaling 0.134437 0.871
R-HSA-5633007 Regulation of TP53 Activity 0.148144 0.829
R-HSA-193704 p75 NTR receptor-mediated signalling 0.049700 1.304
R-HSA-9730414 MITF-M-regulated melanocyte development 0.251877 0.599
R-HSA-9020591 Interleukin-12 signaling 0.130196 0.885
R-HSA-449147 Signaling by Interleukins 0.207699 0.683
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.235531 0.628
R-HSA-447115 Interleukin-12 family signaling 0.160874 0.794
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.269217 0.570
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.269217 0.570
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.271970 0.565
R-HSA-8941326 RUNX2 regulates bone development 0.274479 0.561
R-HSA-111933 Calmodulin induced events 0.274479 0.561
R-HSA-111997 CaM pathway 0.274479 0.561
R-HSA-1296072 Voltage gated Potassium channels 0.279880 0.553
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.279880 0.553
R-HSA-933541 TRAF6 mediated IRF7 activation 0.279880 0.553
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.279880 0.553
R-HSA-162906 HIV Infection 0.279949 0.553
R-HSA-69206 G1/S Transition 0.280227 0.552
R-HSA-212436 Generic Transcription Pathway 0.282482 0.549
R-HSA-6785470 tRNA processing in the mitochondrion 0.285242 0.545
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.285242 0.545
R-HSA-8875878 MET promotes cell motility 0.285242 0.545
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.285242 0.545
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.288477 0.540
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.290563 0.537
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.290563 0.537
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.290563 0.537
R-HSA-201556 Signaling by ALK 0.290563 0.537
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.293972 0.532
R-HSA-3247509 Chromatin modifying enzymes 0.294103 0.531
R-HSA-73857 RNA Polymerase II Transcription 0.295460 0.530
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.295845 0.529
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.295845 0.529
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.295845 0.529
R-HSA-167169 HIV Transcription Elongation 0.295845 0.529
R-HSA-177243 Interactions of Rev with host cellular proteins 0.295845 0.529
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.295845 0.529
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.295845 0.529
R-HSA-5260271 Diseases of Immune System 0.295845 0.529
R-HSA-8868766 rRNA processing in the mitochondrion 0.295845 0.529
R-HSA-202433 Generation of second messenger molecules 0.295845 0.529
R-HSA-8982491 Glycogen metabolism 0.295845 0.529
R-HSA-1474165 Reproduction 0.296718 0.528
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.301089 0.521
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.301089 0.521
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.301089 0.521
R-HSA-3214841 PKMTs methylate histone lysines 0.301089 0.521
R-HSA-5655302 Signaling by FGFR1 in disease 0.306293 0.514
R-HSA-6811438 Intra-Golgi traffic 0.306293 0.514
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.306293 0.514
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.306293 0.514
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.306293 0.514
R-HSA-9683701 Translation of Structural Proteins 0.306293 0.514
R-HSA-111996 Ca-dependent events 0.311459 0.507
R-HSA-3858494 Beta-catenin independent WNT signaling 0.315888 0.500
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.321678 0.493
R-HSA-3928662 EPHB-mediated forward signaling 0.321678 0.493
R-HSA-2172127 DAP12 interactions 0.321678 0.493
R-HSA-373752 Netrin-1 signaling 0.321678 0.493
R-HSA-69236 G1 Phase 0.321678 0.493
R-HSA-69231 Cyclin D associated events in G1 0.321678 0.493
R-HSA-4839726 Chromatin organization 0.324572 0.489
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.326730 0.486
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.326730 0.486
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.326730 0.486
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.326730 0.486
R-HSA-1489509 DAG and IP3 signaling 0.326730 0.486
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.326793 0.486
R-HSA-9664417 Leishmania phagocytosis 0.326793 0.486
R-HSA-9664407 Parasite infection 0.326793 0.486
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.329512 0.482
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.331745 0.479
R-HSA-2299718 Condensation of Prophase Chromosomes 0.331745 0.479
R-HSA-5357905 Regulation of TNFR1 signaling 0.331745 0.479
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.334841 0.475
R-HSA-162599 Late Phase of HIV Life Cycle 0.334943 0.475
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.334943 0.475
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 0.336723 0.473
R-HSA-389356 Co-stimulation by CD28 0.341665 0.466
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.345765 0.461
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.346570 0.460
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.346570 0.460
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.346570 0.460
R-HSA-69242 S Phase 0.351155 0.455
R-HSA-166520 Signaling by NTRKs 0.351155 0.455
R-HSA-109704 PI3K Cascade 0.351438 0.454
R-HSA-68886 M Phase 0.353475 0.452
R-HSA-9864848 Complex IV assembly 0.356271 0.448
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.361068 0.442
R-HSA-68949 Orc1 removal from chromatin 0.361068 0.442
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.361068 0.442
R-HSA-69306 DNA Replication 0.364564 0.438
R-HSA-5693532 DNA Double-Strand Break Repair 0.364564 0.438
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.365829 0.437
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.367234 0.435
R-HSA-1989781 PPARA activates gene expression 0.369899 0.432
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.370009 0.432
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.370555 0.431
R-HSA-9610379 HCMV Late Events 0.375217 0.426
R-HSA-162587 HIV Life Cycle 0.375217 0.426
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.375217 0.426
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.375247 0.426
R-HSA-3214815 HDACs deacetylate histones 0.375247 0.426
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.379903 0.420
R-HSA-75893 TNF signaling 0.379903 0.420
R-HSA-177929 Signaling by EGFR 0.379903 0.420
R-HSA-112399 IRS-mediated signalling 0.384526 0.415
R-HSA-2980766 Nuclear Envelope Breakdown 0.384526 0.415
R-HSA-1483166 Synthesis of PA 0.384526 0.415
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.384526 0.415
R-HSA-109581 Apoptosis 0.388432 0.411
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.389114 0.410
R-HSA-9658195 Leishmania infection 0.389416 0.410
R-HSA-9824443 Parasitic Infection Pathways 0.389416 0.410
R-HSA-191859 snRNP Assembly 0.393668 0.405
R-HSA-194441 Metabolism of non-coding RNA 0.393668 0.405
R-HSA-9033241 Peroxisomal protein import 0.393668 0.405
R-HSA-429914 Deadenylation-dependent mRNA decay 0.393668 0.405
R-HSA-180786 Extension of Telomeres 0.393668 0.405
R-HSA-1227986 Signaling by ERBB2 0.398188 0.400
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.398188 0.400
R-HSA-2428928 IRS-related events triggered by IGF1R 0.402675 0.395
R-HSA-168325 Viral Messenger RNA Synthesis 0.402675 0.395
R-HSA-450294 MAP kinase activation 0.402675 0.395
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.402675 0.395
R-HSA-112043 PLC beta mediated events 0.402675 0.395
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.407129 0.390
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.407129 0.390
R-HSA-186797 Signaling by PDGF 0.407129 0.390
R-HSA-373755 Semaphorin interactions 0.411550 0.386
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.411550 0.386
R-HSA-8848021 Signaling by PTK6 0.411550 0.386
R-HSA-72306 tRNA processing 0.411905 0.385
R-HSA-5621481 C-type lectin receptors (CLRs) 0.414486 0.382
R-HSA-74751 Insulin receptor signalling cascade 0.415939 0.381
R-HSA-2428924 IGF1R signaling cascade 0.415939 0.381
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.415939 0.381
R-HSA-5689880 Ub-specific processing proteases 0.419633 0.377
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.420294 0.376
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.422197 0.374
R-HSA-195721 Signaling by WNT 0.423332 0.373
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.424756 0.372
R-HSA-9678108 SARS-CoV-1 Infection 0.424756 0.372
R-HSA-196807 Nicotinate metabolism 0.428910 0.368
R-HSA-112040 G-protein mediated events 0.428910 0.368
R-HSA-9679506 SARS-CoV Infections 0.429105 0.367
R-HSA-1280215 Cytokine Signaling in Immune system 0.430513 0.366
R-HSA-167172 Transcription of the HIV genome 0.433169 0.363
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.433169 0.363
R-HSA-2559583 Cellular Senescence 0.437463 0.359
R-HSA-69202 Cyclin E associated events during G1/S transition 0.441595 0.355
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.441595 0.355
R-HSA-448424 Interleukin-17 signaling 0.441595 0.355
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.441595 0.355
R-HSA-453276 Regulation of mitotic cell cycle 0.445761 0.351
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.445761 0.351
R-HSA-5632684 Hedgehog 'on' state 0.445761 0.351
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.449896 0.347
R-HSA-5578749 Transcriptional regulation by small RNAs 0.449896 0.347
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.449896 0.347
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.454001 0.343
R-HSA-4086398 Ca2+ pathway 0.454001 0.343
R-HSA-1226099 Signaling by FGFR in disease 0.458075 0.339
R-HSA-8852135 Protein ubiquitination 0.462119 0.335
R-HSA-1169408 ISG15 antiviral mechanism 0.462119 0.335
R-HSA-1980143 Signaling by NOTCH1 0.466133 0.331
R-HSA-9694635 Translation of Structural Proteins 0.470118 0.328
R-HSA-212165 Epigenetic regulation of gene expression 0.471997 0.326
R-HSA-112315 Transmission across Chemical Synapses 0.471997 0.326
R-HSA-4086400 PCP/CE pathway 0.474072 0.324
R-HSA-9609690 HCMV Early Events 0.477081 0.321
R-HSA-6806834 Signaling by MET 0.481895 0.317
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.489602 0.310
R-HSA-9707564 Cytoprotection by HMOX1 0.493412 0.307
R-HSA-1483206 Glycerophospholipid biosynthesis 0.493882 0.306
R-HSA-112316 Neuronal System 0.496200 0.304
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.497195 0.303
R-HSA-5687128 MAPK6/MAPK4 signaling 0.500949 0.300
R-HSA-5357801 Programmed Cell Death 0.500978 0.300
R-HSA-9006925 Intracellular signaling by second messengers 0.507740 0.294
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.508375 0.294
R-HSA-438064 Post NMDA receptor activation events 0.512047 0.291
R-HSA-2262752 Cellular responses to stress 0.514141 0.289
R-HSA-9663891 Selective autophagy 0.515691 0.288
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.517290 0.286
R-HSA-1236974 ER-Phagosome pathway 0.519309 0.285
R-HSA-9694516 SARS-CoV-2 Infection 0.520596 0.283
R-HSA-112310 Neurotransmitter release cycle 0.522899 0.282
R-HSA-74752 Signaling by Insulin receptor 0.533513 0.273
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.533513 0.273
R-HSA-68867 Assembly of the pre-replicative complex 0.536998 0.270
R-HSA-73894 DNA Repair 0.540432 0.267
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.543892 0.264
R-HSA-388396 GPCR downstream signalling 0.545910 0.263
R-HSA-1296071 Potassium Channels 0.550684 0.259
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.550684 0.259
R-HSA-9705683 SARS-CoV-2-host interactions 0.553238 0.257
R-HSA-157579 Telomere Maintenance 0.554042 0.256
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.557375 0.254
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.557375 0.254
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.557375 0.254
R-HSA-3214847 HATs acetylate histones 0.560684 0.251
R-HSA-9614085 FOXO-mediated transcription 0.560684 0.251
R-HSA-192105 Synthesis of bile acids and bile salts 0.560684 0.251
R-HSA-70171 Glycolysis 0.563968 0.249
R-HSA-9842860 Regulation of endogenous retroelements 0.570463 0.244
R-HSA-2559580 Oxidative Stress Induced Senescence 0.570463 0.244
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.570463 0.244
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.576862 0.239
R-HSA-111885 Opioid Signalling 0.576862 0.239
R-HSA-418346 Platelet homeostasis 0.586285 0.232
R-HSA-9692914 SARS-CoV-1-host interactions 0.586285 0.232
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.592450 0.227
R-HSA-1236975 Antigen processing-Cross presentation 0.592450 0.227
R-HSA-69002 DNA Replication Pre-Initiation 0.595499 0.225
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.595499 0.225
R-HSA-202403 TCR signaling 0.598525 0.223
R-HSA-194068 Bile acid and bile salt metabolism 0.598525 0.223
R-HSA-9609646 HCMV Infection 0.599547 0.222
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.604509 0.219
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.604509 0.219
R-HSA-2871796 FCERI mediated MAPK activation 0.604509 0.219
R-HSA-1483249 Inositol phosphate metabolism 0.604509 0.219
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.607468 0.216
R-HSA-422475 Axon guidance 0.611913 0.213
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.616214 0.210
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.616214 0.210
R-HSA-70326 Glucose metabolism 0.624767 0.204
R-HSA-9824446 Viral Infection Pathways 0.628888 0.201
R-HSA-3371556 Cellular response to heat stress 0.635877 0.197
R-HSA-73886 Chromosome Maintenance 0.635877 0.197
R-HSA-372790 Signaling by GPCR 0.643407 0.192
R-HSA-6809371 Formation of the cornified envelope 0.643995 0.191
R-HSA-76002 Platelet activation, signaling and aggregation 0.645892 0.190
R-HSA-8953897 Cellular responses to stimuli 0.646430 0.189
R-HSA-977606 Regulation of Complement cascade 0.646661 0.189
R-HSA-114608 Platelet degranulation 0.654541 0.184
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.655002 0.184
R-HSA-9675108 Nervous system development 0.661442 0.180
R-HSA-5576891 Cardiac conduction 0.667288 0.176
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.672256 0.172
R-HSA-9018519 Estrogen-dependent gene expression 0.681971 0.166
R-HSA-1483257 Phospholipid metabolism 0.682912 0.166
R-HSA-1257604 PIP3 activates AKT signaling 0.682912 0.166
R-HSA-5358351 Signaling by Hedgehog 0.686720 0.163
R-HSA-381119 Unfolded Protein Response (UPR) 0.689069 0.162
R-HSA-1632852 Macroautophagy 0.693714 0.159
R-HSA-8856828 Clathrin-mediated endocytosis 0.700552 0.155
R-HSA-166658 Complement cascade 0.705027 0.152
R-HSA-9609507 Protein localization 0.722271 0.141
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.724355 0.140
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.726424 0.139
R-HSA-9612973 Autophagy 0.728477 0.138
R-HSA-1643685 Disease 0.741136 0.130
R-HSA-5619102 SLC transporter disorders 0.750078 0.125
R-HSA-5683057 MAPK family signaling cascades 0.761142 0.119
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.762927 0.118
R-HSA-9664433 Leishmania parasite growth and survival 0.762927 0.118
R-HSA-8953854 Metabolism of RNA 0.770059 0.113
R-HSA-611105 Respiratory electron transport 0.771702 0.113
R-HSA-168255 Influenza Infection 0.773418 0.112
R-HSA-201681 TCF dependent signaling in response to WNT 0.780155 0.108
R-HSA-3781865 Diseases of glycosylation 0.781808 0.107
R-HSA-69275 G2/M Transition 0.785076 0.105
R-HSA-453274 Mitotic G2-G2/M phases 0.788297 0.103
R-HSA-168249 Innate Immune System 0.796955 0.099
R-HSA-72163 mRNA Splicing - Major Pathway 0.797674 0.098
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.806204 0.094
R-HSA-913531 Interferon Signaling 0.806204 0.094
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.806638 0.093
R-HSA-428157 Sphingolipid metabolism 0.808094 0.093
R-HSA-376176 Signaling by ROBO receptors 0.810972 0.091
R-HSA-72172 mRNA Splicing 0.813807 0.089
R-HSA-6805567 Keratinization 0.816600 0.088
R-HSA-418594 G alpha (i) signalling events 0.831273 0.080
R-HSA-5663205 Infectious disease 0.832447 0.080
R-HSA-8878171 Transcriptional regulation by RUNX1 0.842345 0.075
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.845884 0.073
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.847046 0.072
R-HSA-72312 rRNA processing 0.849345 0.071
R-HSA-8939211 ESR-mediated signaling 0.854942 0.068
R-HSA-109582 Hemostasis 0.855493 0.068
R-HSA-157118 Signaling by NOTCH 0.858200 0.066
R-HSA-5619115 Disorders of transmembrane transporters 0.865524 0.063
R-HSA-421270 Cell-cell junction organization 0.869540 0.061
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.872885 0.059
R-HSA-388841 Regulation of T cell activation by CD28 family 0.874392 0.058
R-HSA-6798695 Neutrophil degranulation 0.874397 0.058
R-HSA-416476 G alpha (q) signalling events 0.881786 0.055
R-HSA-9711123 Cellular response to chemical stress 0.885320 0.053
R-HSA-446728 Cell junction organization 0.893702 0.049
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.896882 0.047
R-HSA-5673001 RAF/MAP kinase cascade 0.902222 0.045
R-HSA-1280218 Adaptive Immune System 0.905324 0.043
R-HSA-5684996 MAPK1/MAPK3 signaling 0.907288 0.042
R-HSA-1500931 Cell-Cell communication 0.920371 0.036
R-HSA-8957322 Metabolism of steroids 0.925076 0.034
R-HSA-1266738 Developmental Biology 0.931578 0.031
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.934178 0.030
R-HSA-168256 Immune System 0.941129 0.026
R-HSA-9006931 Signaling by Nuclear Receptors 0.944347 0.025
R-HSA-196854 Metabolism of vitamins and cofactors 0.944770 0.025
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.956419 0.019
R-HSA-199991 Membrane Trafficking 0.961885 0.017
R-HSA-5668914 Diseases of metabolism 0.966150 0.015
R-HSA-597592 Post-translational protein modification 0.972337 0.012
R-HSA-556833 Metabolism of lipids 0.973246 0.012
R-HSA-5653656 Vesicle-mediated transport 0.986777 0.006
R-HSA-500792 GPCR ligand binding 0.990285 0.004
R-HSA-392499 Metabolism of proteins 0.990516 0.004
R-HSA-1430728 Metabolism 0.999996 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
PRKD1PRKD1 0.755 0.250 -3 0.711
PRKD2PRKD2 0.750 0.160 -3 0.689
COTCOT 0.749 0.089 2 0.869
NDR2NDR2 0.744 0.061 -3 0.767
CLK3CLK3 0.743 0.085 1 0.733
MTORMTOR 0.742 0.155 1 0.697
NUAK2NUAK2 0.742 0.154 -3 0.723
CDC7CDC7 0.736 0.058 1 0.766
MOSMOS 0.736 0.083 1 0.775
MAPKAPK3MAPKAPK3 0.736 0.070 -3 0.675
CAMK2DCAMK2D 0.735 0.111 -3 0.701
WNK1WNK1 0.734 0.100 -2 0.850
MAPKAPK2MAPKAPK2 0.734 0.062 -3 0.642
HIPK4HIPK4 0.734 0.067 1 0.704
MARK4MARK4 0.733 0.149 4 0.812
TSSK1TSSK1 0.733 0.199 -3 0.768
MST4MST4 0.732 0.104 2 0.887
KISKIS 0.731 0.072 1 0.600
PIM3PIM3 0.731 -0.006 -3 0.718
LATS2LATS2 0.731 0.009 -5 0.325
CAMK2BCAMK2B 0.730 0.112 2 0.792
CAMK1BCAMK1B 0.730 0.077 -3 0.693
PKN2PKN2 0.729 0.101 -3 0.702
CAMK2ACAMK2A 0.729 0.103 2 0.823
QSKQSK 0.729 0.149 4 0.788
CHK1CHK1 0.729 0.214 -3 0.746
TSSK2TSSK2 0.728 0.211 -5 0.568
PDHK4PDHK4 0.728 -0.012 1 0.767
PIM1PIM1 0.728 0.039 -3 0.665
AMPKA1AMPKA1 0.728 0.108 -3 0.743
NDR1NDR1 0.728 0.004 -3 0.730
SKMLCKSKMLCK 0.728 0.046 -2 0.820
NLKNLK 0.727 0.040 1 0.742
PRKD3PRKD3 0.727 0.134 -3 0.612
CDKL1CDKL1 0.727 0.041 -3 0.625
PRPKPRPK 0.727 -0.035 -1 0.626
RAF1RAF1 0.727 0.013 1 0.782
PKN3PKN3 0.727 0.049 -3 0.684
ATRATR 0.726 0.026 1 0.738
IKKBIKKB 0.726 -0.030 -2 0.693
RSK2RSK2 0.726 0.023 -3 0.643
CDK18CDK18 0.726 0.094 1 0.538
CDK8CDK8 0.726 0.046 1 0.584
SIKSIK 0.725 0.132 -3 0.648
CDK19CDK19 0.725 0.053 1 0.550
QIKQIK 0.725 0.155 -3 0.699
PKCDPKCD 0.725 0.069 2 0.836
AMPKA2AMPKA2 0.725 0.091 -3 0.725
NUAK1NUAK1 0.724 0.099 -3 0.681
GCN2GCN2 0.724 -0.074 2 0.803
ERK5ERK5 0.724 0.033 1 0.688
CDKL5CDKL5 0.723 0.031 -3 0.623
NIKNIK 0.723 0.088 -3 0.727
NEK6NEK6 0.723 -0.012 -2 0.795
GRK1GRK1 0.723 0.051 -2 0.767
MNK2MNK2 0.723 0.062 -2 0.739
BCKDKBCKDK 0.722 -0.012 -1 0.609
DSTYKDSTYK 0.722 -0.043 2 0.908
CAMK2GCAMK2G 0.722 -0.012 2 0.820
PKCAPKCA 0.722 0.100 2 0.802
TBK1TBK1 0.722 -0.035 1 0.684
SRPK1SRPK1 0.721 0.001 -3 0.592
PKCGPKCG 0.721 0.075 2 0.811
P90RSKP90RSK 0.720 0.008 -3 0.637
PKCBPKCB 0.720 0.075 2 0.808
BMPR2BMPR2 0.720 -0.073 -2 0.826
IKKEIKKE 0.719 -0.040 1 0.689
CDK7CDK7 0.719 0.028 1 0.601
PDHK1PDHK1 0.719 -0.055 1 0.759
MARK3MARK3 0.718 0.128 4 0.749
BUB1BUB1 0.718 0.340 -5 0.658
ICKICK 0.718 0.037 -3 0.681
IKKAIKKA 0.718 -0.015 -2 0.698
AURCAURC 0.717 0.009 -2 0.587
PHKG1PHKG1 0.717 0.049 -3 0.724
PKACGPKACG 0.717 -0.004 -2 0.680
LATS1LATS1 0.717 0.051 -3 0.786
CAMK4CAMK4 0.717 0.041 -3 0.705
NEK7NEK7 0.716 -0.059 -3 0.707
GRK5GRK5 0.716 -0.027 -3 0.671
DAPK2DAPK2 0.716 0.021 -3 0.709
TGFBR2TGFBR2 0.716 -0.027 -2 0.710
CHAK2CHAK2 0.716 -0.026 -1 0.584
CK1ECK1E 0.715 0.067 -3 0.448
MNK1MNK1 0.715 0.046 -2 0.747
MLK1MLK1 0.715 -0.020 2 0.844
RSK3RSK3 0.715 -0.016 -3 0.620
RIPK3RIPK3 0.715 -0.048 3 0.707
NEK9NEK9 0.715 -0.028 2 0.850
ULK2ULK2 0.714 -0.105 2 0.766
GRK7GRK7 0.713 0.076 1 0.697
CDK17CDK17 0.713 0.061 1 0.494
MLK2MLK2 0.713 -0.021 2 0.829
BMPR1BBMPR1B 0.713 0.077 1 0.773
CDK1CDK1 0.713 0.045 1 0.573
MARK2MARK2 0.713 0.118 4 0.722
CAMLCKCAMLCK 0.713 -0.020 -2 0.784
HIPK2HIPK2 0.713 0.043 1 0.536
MLK3MLK3 0.713 0.034 2 0.812
PKACBPKACB 0.713 0.015 -2 0.607
MASTLMASTL 0.712 -0.046 -2 0.781
BRSK1BRSK1 0.712 0.030 -3 0.675
DYRK2DYRK2 0.712 0.022 1 0.606
PRKXPRKX 0.712 0.027 -3 0.637
NIM1NIM1 0.712 0.075 3 0.744
DNAPKDNAPK 0.712 0.051 1 0.650
HUNKHUNK 0.712 -0.048 2 0.758
MPSK1MPSK1 0.711 0.159 1 0.730
PKCZPKCZ 0.711 0.031 2 0.826
MELKMELK 0.711 0.030 -3 0.697
RSK4RSK4 0.710 -0.000 -3 0.650
BRSK2BRSK2 0.710 0.025 -3 0.701
DLKDLK 0.709 -0.017 1 0.755
ATMATM 0.709 -0.017 1 0.679
P70S6KBP70S6KB 0.709 -0.048 -3 0.657
SRPK2SRPK2 0.709 -0.022 -3 0.523
MARK1MARK1 0.709 0.106 4 0.763
CLK1CLK1 0.709 0.018 -3 0.619
CK1DCK1D 0.709 0.079 -3 0.406
CDK5CDK5 0.708 0.044 1 0.620
GRK6GRK6 0.708 -0.021 1 0.773
HIPK1HIPK1 0.708 0.034 1 0.625
WNK3WNK3 0.708 -0.120 1 0.740
NEK2NEK2 0.708 0.003 2 0.842
P38AP38A 0.707 0.050 1 0.613
MST3MST3 0.707 0.126 2 0.880
CLK4CLK4 0.707 0.002 -3 0.632
RIPK1RIPK1 0.707 -0.058 1 0.724
PKCHPKCH 0.707 0.038 2 0.773
YSK4YSK4 0.706 0.001 1 0.721
SMG1SMG1 0.706 -0.029 1 0.694
ANKRD3ANKRD3 0.706 -0.046 1 0.768
SGK3SGK3 0.706 0.021 -3 0.644
JNK2JNK2 0.706 0.034 1 0.550
FAM20CFAM20C 0.706 0.008 2 0.589
CDK16CDK16 0.706 0.070 1 0.507
PKRPKR 0.706 -0.007 1 0.763
CDK13CDK13 0.705 0.012 1 0.571
CAMK1GCAMK1G 0.705 0.039 -3 0.614
TGFBR1TGFBR1 0.705 0.019 -2 0.744
IRE1IRE1 0.705 -0.028 1 0.715
CLK2CLK2 0.705 0.029 -3 0.629
GRK4GRK4 0.705 -0.056 -2 0.783
TAO3TAO3 0.704 0.118 1 0.734
SRPK3SRPK3 0.704 -0.015 -3 0.545
MSK2MSK2 0.704 -0.034 -3 0.594
CK1G1CK1G1 0.704 0.051 -3 0.429
P38BP38B 0.704 0.050 1 0.541
CK1A2CK1A2 0.704 0.071 -3 0.401
ERK1ERK1 0.704 0.033 1 0.537
MYLK4MYLK4 0.704 -0.001 -2 0.703
PAK1PAK1 0.703 -0.049 -2 0.730
DCAMKL1DCAMKL1 0.703 0.038 -3 0.709
PASKPASK 0.703 0.076 -3 0.738
ALK4ALK4 0.703 -0.011 -2 0.764
CDK14CDK14 0.703 0.059 1 0.586
PAK6PAK6 0.702 0.009 -2 0.620
CAMK1DCAMK1D 0.701 0.055 -3 0.593
MSK1MSK1 0.701 -0.016 -3 0.603
TTBK2TTBK2 0.701 -0.085 2 0.718
ULK1ULK1 0.701 -0.140 -3 0.653
PKG2PKG2 0.701 -0.015 -2 0.607
MAPKAPK5MAPKAPK5 0.700 -0.042 -3 0.556
GCKGCK 0.700 0.143 1 0.787
P38GP38G 0.700 0.023 1 0.486
CDK10CDK10 0.700 0.037 1 0.573
PAK3PAK3 0.700 -0.071 -2 0.726
CDK12CDK12 0.700 0.014 1 0.546
PIM2PIM2 0.699 -0.023 -3 0.609
JNK3JNK3 0.699 0.004 1 0.568
AKT2AKT2 0.699 -0.011 -3 0.564
CDK3CDK3 0.699 0.033 1 0.510
AURBAURB 0.699 -0.026 -2 0.581
CDK9CDK9 0.698 -0.002 1 0.574
DRAK1DRAK1 0.698 0.036 1 0.760
MEK1MEK1 0.698 -0.021 2 0.794
GRK2GRK2 0.698 0.035 -2 0.668
WNK4WNK4 0.698 0.010 -2 0.838
ACVR2AACVR2A 0.697 0.017 -2 0.699
ACVR2BACVR2B 0.697 0.003 -2 0.716
HIPK3HIPK3 0.697 0.015 1 0.615
TLK2TLK2 0.697 -0.050 1 0.738
PKCEPKCE 0.696 0.051 2 0.800
DYRK4DYRK4 0.696 0.014 1 0.542
HPK1HPK1 0.696 0.129 1 0.774
SSTKSSTK 0.696 0.038 4 0.765
MLK4MLK4 0.695 -0.043 2 0.766
ALK2ALK2 0.695 -0.019 -2 0.741
CAMK1ACAMK1A 0.695 0.076 -3 0.543
DCAMKL2DCAMKL2 0.695 0.034 -3 0.712
NEK5NEK5 0.695 0.006 1 0.742
PRP4PRP4 0.695 0.026 -3 0.657
PLK1PLK1 0.695 -0.068 -2 0.739
PHKG2PHKG2 0.695 0.013 -3 0.681
PKCIPKCI 0.695 0.041 2 0.806
PKACAPKACA 0.694 -0.005 -2 0.551
VRK2VRK2 0.694 -0.106 1 0.757
CHK2CHK2 0.694 0.056 -3 0.522
MAKMAK 0.694 0.077 -2 0.756
PKCTPKCT 0.694 0.014 2 0.777
IRE2IRE2 0.694 -0.068 2 0.752
MEKK3MEKK3 0.693 -0.004 1 0.736
MEKK1MEKK1 0.692 -0.052 1 0.725
AURAAURA 0.692 -0.025 -2 0.553
CHAK1CHAK1 0.692 -0.103 2 0.786
DYRK1BDYRK1B 0.692 -0.001 1 0.577
CDK2CDK2 0.692 -0.015 1 0.649
DYRK1ADYRK1A 0.692 -0.011 1 0.643
ERK2ERK2 0.692 -0.008 1 0.582
SMMLCKSMMLCK 0.692 -0.013 -3 0.649
PAK2PAK2 0.692 -0.070 -2 0.706
KHS2KHS2 0.692 0.129 1 0.776
MEK5MEK5 0.691 -0.039 2 0.800
GSK3AGSK3A 0.691 0.033 4 0.403
NEK11NEK11 0.691 0.043 1 0.734
AKT1AKT1 0.691 -0.005 -3 0.606
PLK4PLK4 0.691 -0.003 2 0.554
BMPR1ABMPR1A 0.691 0.025 1 0.745
ERK7ERK7 0.690 0.072 2 0.698
ZAKZAK 0.690 -0.019 1 0.700
PKN1PKN1 0.690 0.037 -3 0.589
MEKK2MEKK2 0.689 -0.015 2 0.797
GAKGAK 0.689 0.048 1 0.780
P38DP38D 0.689 0.022 1 0.491
PINK1PINK1 0.688 -0.101 1 0.757
TNIKTNIK 0.688 0.074 3 0.817
GRK3GRK3 0.688 0.034 -2 0.628
KHS1KHS1 0.688 0.100 1 0.747
DYRK3DYRK3 0.687 -0.013 1 0.624
TLK1TLK1 0.687 -0.072 -2 0.776
SBKSBK 0.687 0.023 -3 0.465
BRAFBRAF 0.687 -0.072 -4 0.549
TAO2TAO2 0.687 0.026 2 0.876
CK1ACK1A 0.687 0.086 -3 0.332
MAP3K15MAP3K15 0.686 0.084 1 0.683
PLK3PLK3 0.686 -0.089 2 0.747
PERKPERK 0.686 -0.101 -2 0.744
HRIHRI 0.686 -0.117 -2 0.766
CK2A2CK2A2 0.686 0.037 1 0.701
SNRKSNRK 0.686 -0.116 2 0.623
HGKHGK 0.685 0.052 3 0.814
MINKMINK 0.685 0.065 1 0.753
MST2MST2 0.685 0.034 1 0.756
LKB1LKB1 0.684 -0.058 -3 0.728
MOKMOK 0.684 0.032 1 0.628
IRAK4IRAK4 0.684 -0.085 1 0.706
DAPK3DAPK3 0.684 -0.001 -3 0.685
GSK3BGSK3B 0.683 -0.004 4 0.392
NEK4NEK4 0.682 -0.009 1 0.734
MEKK6MEKK6 0.682 0.038 1 0.717
ROCK2ROCK2 0.681 -0.001 -3 0.686
PAK5PAK5 0.681 -0.039 -2 0.571
SLKSLK 0.681 0.002 -2 0.675
P70S6KP70S6K 0.680 -0.074 -3 0.558
NEK1NEK1 0.680 0.048 1 0.720
PDK1PDK1 0.679 -0.029 1 0.694
DAPK1DAPK1 0.679 0.003 -3 0.650
SGK1SGK1 0.679 -0.011 -3 0.494
LOKLOK 0.678 -0.015 -2 0.722
LRRK2LRRK2 0.678 -0.002 2 0.858
YSK1YSK1 0.678 0.066 2 0.848
JNK1JNK1 0.677 -0.003 1 0.540
TAK1TAK1 0.677 -0.012 1 0.774
MRCKBMRCKB 0.677 -0.026 -3 0.614
AKT3AKT3 0.677 -0.026 -3 0.519
CDK6CDK6 0.677 0.007 1 0.559
MRCKAMRCKA 0.676 -0.027 -3 0.642
NEK8NEK8 0.676 -0.085 2 0.834
PAK4PAK4 0.676 -0.044 -2 0.579
MST1MST1 0.675 0.001 1 0.745
CK2A1CK2A1 0.675 0.027 1 0.693
PBKPBK 0.675 0.014 1 0.706
CAMKK1CAMKK1 0.674 -0.127 -2 0.689
TTBK1TTBK1 0.674 -0.097 2 0.633
CDK4CDK4 0.674 -0.008 1 0.539
EEF2KEEF2K 0.673 -0.003 3 0.775
CAMKK2CAMKK2 0.673 -0.113 -2 0.681
DMPK1DMPK1 0.670 0.001 -3 0.648
IRAK1IRAK1 0.670 -0.151 -1 0.528
VRK1VRK1 0.668 -0.097 2 0.804
PLK2PLK2 0.667 -0.045 -3 0.597
HASPINHASPIN 0.667 -0.012 -1 0.516
PDHK3_TYRPDHK3_TYR 0.666 0.160 4 0.848
ROCK1ROCK1 0.666 -0.023 -3 0.638
CRIKCRIK 0.665 -0.023 -3 0.598
BIKEBIKE 0.664 0.041 1 0.672
MYO3BMYO3B 0.664 0.039 2 0.860
PDHK4_TYRPDHK4_TYR 0.662 0.123 2 0.856
STK33STK33 0.662 -0.099 2 0.616
TAO1TAO1 0.662 0.016 1 0.660
OSR1OSR1 0.661 -0.030 2 0.793
AAK1AAK1 0.661 0.084 1 0.584
NEK3NEK3 0.660 -0.062 1 0.664
PKG1PKG1 0.658 -0.062 -2 0.525
MYO3AMYO3A 0.657 0.026 1 0.738
RIPK2RIPK2 0.657 -0.129 1 0.660
MAP2K4_TYRMAP2K4_TYR 0.657 0.101 -1 0.662
CK1G3CK1G3 0.656 0.051 -3 0.291
MEK2MEK2 0.656 -0.126 2 0.759
ASK1ASK1 0.655 -0.014 1 0.666
TESK1_TYRTESK1_TYR 0.655 0.021 3 0.852
PKMYT1_TYRPKMYT1_TYR 0.654 0.089 3 0.818
PDHK1_TYRPDHK1_TYR 0.653 0.047 -1 0.641
MAP2K6_TYRMAP2K6_TYR 0.653 0.027 -1 0.651
BMPR2_TYRBMPR2_TYR 0.652 0.036 -1 0.640
LIMK2_TYRLIMK2_TYR 0.652 0.022 -3 0.759
MAP2K7_TYRMAP2K7_TYR 0.651 -0.006 2 0.832
TTKTTK 0.651 -0.061 -2 0.752
YANK3YANK3 0.648 -0.020 2 0.424
PINK1_TYRPINK1_TYR 0.644 -0.080 1 0.741
LIMK1_TYRLIMK1_TYR 0.644 -0.018 2 0.839
TXKTXK 0.640 0.030 1 0.772
TYK2TYK2 0.639 -0.050 1 0.699
RETRET 0.638 -0.106 1 0.704
ABL2ABL2 0.636 -0.038 -1 0.570
FGRFGR 0.636 -0.052 1 0.759
ALPHAK3ALPHAK3 0.636 -0.103 -1 0.536
MST1RMST1R 0.636 -0.089 3 0.770
JAK2JAK2 0.636 -0.039 1 0.689
EPHB4EPHB4 0.635 -0.070 -1 0.569
EPHA6EPHA6 0.634 -0.090 -1 0.580
JAK1JAK1 0.633 0.026 1 0.651
TNK2TNK2 0.633 -0.059 3 0.701
STLK3STLK3 0.633 -0.127 1 0.680
TNNI3K_TYRTNNI3K_TYR 0.632 -0.008 1 0.683
CSF1RCSF1R 0.632 -0.078 3 0.753
ABL1ABL1 0.632 -0.042 -1 0.566
CK1G2CK1G2 0.632 0.018 -3 0.369
TYRO3TYRO3 0.631 -0.107 3 0.751
ROS1ROS1 0.631 -0.087 3 0.716
NEK10_TYRNEK10_TYR 0.631 -0.057 1 0.625
EPHA4EPHA4 0.629 -0.038 2 0.752
ITKITK 0.627 -0.054 -1 0.550
HCKHCK 0.627 -0.069 -1 0.568
WEE1_TYRWEE1_TYR 0.627 -0.040 -1 0.517
SRMSSRMS 0.627 -0.072 1 0.751
TNK1TNK1 0.626 -0.064 3 0.738
FERFER 0.626 -0.097 1 0.754
YES1YES1 0.626 -0.092 -1 0.596
EPHB1EPHB1 0.626 -0.059 1 0.732
DDR1DDR1 0.626 -0.175 4 0.754
LCKLCK 0.625 -0.061 -1 0.561
JAK3JAK3 0.625 -0.124 1 0.672
INSRRINSRR 0.624 -0.090 3 0.697
KITKIT 0.624 -0.093 3 0.754
EPHB3EPHB3 0.623 -0.083 -1 0.551
BMXBMX 0.623 -0.036 -1 0.492
METMET 0.623 -0.077 3 0.747
BLKBLK 0.623 -0.063 -1 0.580
KDRKDR 0.623 -0.102 3 0.723
PDGFRBPDGFRB 0.622 -0.129 3 0.761
FYNFYN 0.621 -0.032 -1 0.547
YANK2YANK2 0.620 -0.021 2 0.441
EPHB2EPHB2 0.620 -0.087 -1 0.544
TECTEC 0.620 -0.061 -1 0.511
MERTKMERTK 0.620 -0.071 3 0.740
PTK2PTK2 0.620 0.030 -1 0.530
AXLAXL 0.620 -0.108 3 0.734
FLT1FLT1 0.619 -0.086 -1 0.567
PDGFRAPDGFRA 0.618 -0.123 3 0.755
BTKBTK 0.617 -0.133 -1 0.529
FGFR2FGFR2 0.617 -0.164 3 0.757
EPHA3EPHA3 0.616 -0.075 2 0.724
EPHA7EPHA7 0.616 -0.068 2 0.753
FLT3FLT3 0.616 -0.144 3 0.742
PTK2BPTK2B 0.615 -0.026 -1 0.527
NTRK1NTRK1 0.615 -0.125 -1 0.566
SYKSYK 0.614 0.009 -1 0.513
LYNLYN 0.614 -0.071 3 0.668
PTK6PTK6 0.613 -0.149 -1 0.491
ALKALK 0.613 -0.111 3 0.669
ERBB2ERBB2 0.613 -0.101 1 0.672
LTKLTK 0.612 -0.118 3 0.704
FRKFRK 0.612 -0.090 -1 0.581
MATKMATK 0.611 -0.092 -1 0.516
NTRK3NTRK3 0.611 -0.093 -1 0.526
FGFR1FGFR1 0.610 -0.170 3 0.722
EPHA1EPHA1 0.610 -0.114 3 0.721
TEKTEK 0.609 -0.177 3 0.671
EPHA5EPHA5 0.609 -0.079 2 0.725
SRCSRC 0.608 -0.074 -1 0.555
CSKCSK 0.608 -0.088 2 0.750
DDR2DDR2 0.607 -0.109 3 0.687
EPHA8EPHA8 0.607 -0.079 -1 0.546
NTRK2NTRK2 0.607 -0.156 3 0.701
EGFREGFR 0.606 -0.071 1 0.572
INSRINSR 0.606 -0.120 3 0.670
FLT4FLT4 0.606 -0.154 3 0.716
FGFR3FGFR3 0.605 -0.155 3 0.727
EPHA2EPHA2 0.602 -0.055 -1 0.511
FGFR4FGFR4 0.600 -0.086 -1 0.518
ERBB4ERBB4 0.598 -0.049 1 0.604
MUSKMUSK 0.597 -0.099 1 0.571
ZAP70ZAP70 0.594 -0.030 -1 0.471
IGF1RIGF1R 0.590 -0.112 3 0.607
FESFES 0.583 -0.086 -1 0.468