Motif 438 (n=143)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2608 | ochoa | Snf2 related CREBBP activator protein | None |
| A6NNZ2 | TUBB8B | S278 | ochoa | Tubulin beta 8B | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| O00192 | ARVCF | S335 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00267 | SUPT5H | S804 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00512 | BCL9 | S157 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O15061 | SYNM | S1080 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43166 | SIPA1L1 | S1568 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O75069 | TMCC2 | S78 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75112 | LDB3 | S508 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75140 | DEPDC5 | S582 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75925 | PIAS1 | S506 | ochoa | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O94804 | STK10 | S469 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94875 | SORBS2 | S278 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O94888 | UBXN7 | S288 | ochoa | UBX domain-containing protein 7 | Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}. |
| O95071 | UBR5 | S621 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95613 | PCNT | S3277 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95817 | BAG3 | S180 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P04350 | TUBB4A | S278 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | S278 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P09874 | PARP1 | S375 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0C7T5 | ATXN1L | S206 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P11274 | BCR | S374 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P16144 | ITGB4 | S1457 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16144 | ITGB4 | S1501 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17302 | GJA1 | S262 | ochoa|psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P18583 | SON | S2181 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18887 | XRCC1 | S226 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19784 | CSNK2A2 | S21 | ochoa | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:30898438). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:11704824, PubMed:16193064, PubMed:30898438). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:19387551, PubMed:19387552). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387551, PubMed:19387552). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| P27448 | MARK3 | S543 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P27448 | MARK3 | S601 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P27816 | MAP4 | S899 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30622 | CLIP1 | S158 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P38398 | BRCA1 | S1486 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P46821 | MAP1B | S544 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S1190 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P50548 | ERF | S150 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P55196 | AFDN | S1782 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55884 | EIF3B | S81 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P68371 | TUBB4B | S278 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78559 | MAP1A | S2259 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82094 | TMF1 | S319 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01970 | PLCB3 | S929 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q03164 | KMT2A | S2101 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07157 | TJP1 | S280 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q09666 | AHNAK | S5400 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13136 | PPFIA1 | S776 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13330 | MTA1 | S460 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13480 | GAB1 | S256 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13761 | RUNX3 | S226 | ochoa | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13835 | PKP1 | S174 | psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q13885 | TUBB2A | S278 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14153 | FAM53B | S151 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
| Q14155 | ARHGEF7 | S159 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14160 | SCRIB | S1279 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14315 | FLNC | S2236 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14676 | MDC1 | S763 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14694 | USP10 | S218 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14699 | RFTN1 | S174 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14938 | NFIX | S271 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q14966 | ZNF638 | S369 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14980 | NUMA1 | S172 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15032 | R3HDM1 | S365 | ochoa | R3H domain-containing protein 1 | None |
| Q15599 | NHERF2 | S272 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15648 | MED1 | S774 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15942 | ZYX | S281 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q2KJY2 | KIF26B | S1144 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q3ZCM7 | TUBB8 | S278 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q5THJ4 | VPS13D | S1727 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VT25 | CDC42BPA | S1654 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VT52 | RPRD2 | S761 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5W0Z9 | ZDHHC20 | S318 | ochoa | Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245). May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. {ECO:0000250|UniProtKB:Q5Y5T1, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:29326245, ECO:0000269|PubMed:33219126}.; FUNCTION: (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q6IAA8 | LAMTOR1 | S45 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6N022 | TENM4 | S199 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6ZRS2 | SRCAP | S2785 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7Z2W4 | ZC3HAV1 | S390 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z7G8 | VPS13B | S1002 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86U44 | METTL3 | S67 | ochoa|psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86U86 | PBRM1 | S319 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UU1 | PHLDB1 | S546 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86WB0 | ZC3HC1 | S338 | ochoa|psp | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86YP4 | GATAD2A | S185 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IX07 | ZFPM1 | S671 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8N1G2 | CMTR1 | S29 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N1I0 | DOCK4 | S1769 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N3F8 | MICALL1 | S619 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3Z6 | ZCCHC7 | S485 | ochoa | Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) | None |
| Q8N612 | FHIP1B | S500 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8N8Z6 | DCBLD1 | S619 | ochoa | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NDX5 | PHC3 | S683 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NHV4 | NEDD1 | S548 | ochoa | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8WUA7 | TBC1D22A | S150 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q8WUZ0 | BCL7C | S106 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
| Q8WWI1 | LMO7 | S1573 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WX93 | PALLD | S728 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE0 | CASKIN2 | S708 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WYP5 | AHCTF1 | Y1145 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92574 | TSC1 | S524 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92585 | MAML1 | S321 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92844 | TANK | S211 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q96AP7 | ESAM | S339 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
| Q96JM3 | CHAMP1 | S267 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S311 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S369 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96PD2 | DCBLD2 | S727 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | None |
| Q9BRR8 | GPATCH1 | S203 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BUF5 | TUBB6 | S278 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S278 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BY77 | POLDIP3 | S386 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BZ29 | DOCK9 | S1255 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C0C2 | TNKS1BP1 | S1121 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S303 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0H2 | TTYH3 | S503 | ochoa | Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3) | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q6P5F7, ECO:0000269|PubMed:15010458}. |
| Q9H0D6 | XRN2 | S451 | ochoa | 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) | Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}. |
| Q9H0J9 | PARP12 | S261 | ochoa | Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252). {ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34187568, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:39465252, ECO:0000269|PubMed:39888989}. |
| Q9H3Q1 | CDC42EP4 | S295 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9HCM4 | EPB41L5 | S405 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NQ84 | GPRC5C | S418 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NQW6 | ANLN | S48 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRA8 | EIF4ENIF1 | S690 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NUQ6 | SPATS2L | S455 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NZ52 | GGA3 | S371 | ochoa | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
| Q9P206 | NHSL3 | S322 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P266 | JCAD | S1307 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2F8 | SIPA1L2 | S1552 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9P2N6 | KANSL3 | S739 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9UHB6 | LIMA1 | S346 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UJM3 | ERRFI1 | S256 | ochoa|psp | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UKI8 | TLK1 | S77 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKI8 | TLK1 | S80 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKK3 | PARP4 | S1338 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULH1 | ASAP1 | S823 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9UNF0 | PACSIN2 | S357 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9UPQ0 | LIMCH1 | S210 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ35 | SRRM2 | S1329 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y520 | PRRC2C | S2035 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y570 | PPME1 | S25 | ochoa | Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}. |
| Q9Y5S2 | CDC42BPB | S1643 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q5VT52 | RPRD2 | S1180 | Sugiyama | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q14671 | PUM1 | S183 | Sugiyama | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| Q14697 | GANAB | S190 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| P51617 | IRAK1 | S571 | Sugiyama | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| Q8N5S9 | CAMKK1 | S57 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q96GD4 | AURKB | S22 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.822909e-11 | 10.317 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 6.829637e-11 | 10.166 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.271657e-09 | 8.644 |
| R-HSA-68877 | Mitotic Prometaphase | 1.567790e-09 | 8.805 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.105842e-09 | 8.387 |
| R-HSA-190861 | Gap junction assembly | 6.060611e-09 | 8.217 |
| R-HSA-9646399 | Aggrephagy | 1.725559e-08 | 7.763 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.371469e-08 | 7.625 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.734539e-08 | 7.563 |
| R-HSA-190828 | Gap junction trafficking | 3.727601e-08 | 7.429 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.853555e-08 | 7.414 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 9.690961e-08 | 7.014 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.223244e-07 | 6.912 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.278014e-07 | 6.642 |
| R-HSA-1632852 | Macroautophagy | 3.023607e-07 | 6.519 |
| R-HSA-983189 | Kinesins | 2.817861e-07 | 6.550 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.001461e-07 | 6.523 |
| R-HSA-9663891 | Selective autophagy | 3.604063e-07 | 6.443 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.105977e-07 | 6.214 |
| R-HSA-9612973 | Autophagy | 7.712174e-07 | 6.113 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 9.514650e-07 | 6.022 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 8.591552e-07 | 6.066 |
| R-HSA-437239 | Recycling pathway of L1 | 9.514650e-07 | 6.022 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.900328e-06 | 5.721 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.315965e-06 | 5.635 |
| R-HSA-69275 | G2/M Transition | 3.677181e-06 | 5.434 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 4.144401e-06 | 5.383 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.028368e-06 | 5.395 |
| R-HSA-5617833 | Cilium Assembly | 4.408568e-06 | 5.356 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.590455e-06 | 5.338 |
| R-HSA-68886 | M Phase | 5.407752e-06 | 5.267 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.844539e-06 | 5.105 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 7.798436e-06 | 5.108 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 8.451869e-06 | 5.073 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.404154e-06 | 5.076 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 9.939640e-06 | 5.003 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.162117e-05 | 4.935 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.172647e-05 | 4.931 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.716834e-05 | 4.765 |
| R-HSA-9833482 | PKR-mediated signaling | 1.986125e-05 | 4.702 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.694013e-05 | 4.570 |
| R-HSA-373760 | L1CAM interactions | 3.121084e-05 | 4.506 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.436311e-05 | 4.464 |
| R-HSA-391251 | Protein folding | 5.018588e-05 | 4.299 |
| R-HSA-112316 | Neuronal System | 5.026531e-05 | 4.299 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.754038e-05 | 4.170 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.671347e-05 | 4.115 |
| R-HSA-68882 | Mitotic Anaphase | 7.428080e-05 | 4.129 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 7.689038e-05 | 4.114 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.067884e-05 | 4.093 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.757565e-05 | 4.058 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.107122e-04 | 3.956 |
| R-HSA-1640170 | Cell Cycle | 1.396294e-04 | 3.855 |
| R-HSA-5620924 | Intraflagellar transport | 1.860979e-04 | 3.730 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.139445e-04 | 3.670 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.034309e-04 | 3.518 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.462680e-04 | 3.263 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.462680e-04 | 3.263 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.929578e-04 | 3.227 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.572811e-04 | 3.182 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 9.023828e-04 | 3.045 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 9.813455e-04 | 3.008 |
| R-HSA-380287 | Centrosome maturation | 1.092575e-03 | 2.962 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.144828e-03 | 2.941 |
| R-HSA-191650 | Regulation of gap junction activity | 1.456536e-03 | 2.837 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 1.456536e-03 | 2.837 |
| R-HSA-199991 | Membrane Trafficking | 1.354545e-03 | 2.868 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.712054e-03 | 2.766 |
| R-HSA-9824446 | Viral Infection Pathways | 1.982907e-03 | 2.703 |
| R-HSA-74160 | Gene expression (Transcription) | 2.191156e-03 | 2.659 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.347667e-03 | 2.629 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 2.558437e-03 | 2.592 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.767769e-03 | 2.424 |
| R-HSA-162582 | Signal Transduction | 3.418212e-03 | 2.466 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.810354e-03 | 2.419 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.812689e-03 | 2.419 |
| R-HSA-9609690 | HCMV Early Events | 3.948575e-03 | 2.404 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.576606e-03 | 2.339 |
| R-HSA-8875656 | MET receptor recycling | 4.750709e-03 | 2.323 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.750709e-03 | 2.323 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 4.750709e-03 | 2.323 |
| R-HSA-212436 | Generic Transcription Pathway | 4.804999e-03 | 2.318 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.392966e-03 | 2.268 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 5.619945e-03 | 2.250 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.791415e-03 | 2.237 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.034143e-03 | 2.095 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 9.071890e-03 | 2.042 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.677306e-03 | 2.014 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 9.754716e-03 | 2.011 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 9.754716e-03 | 2.011 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.017179e-02 | 1.993 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.094658e-02 | 1.961 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.106590e-02 | 1.956 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.219926e-02 | 1.914 |
| R-HSA-9609646 | HCMV Infection | 1.288351e-02 | 1.890 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.351157e-02 | 1.869 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.351157e-02 | 1.869 |
| R-HSA-75153 | Apoptotic execution phase | 1.391986e-02 | 1.856 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.473442e-02 | 1.832 |
| R-HSA-6807070 | PTEN Regulation | 1.510699e-02 | 1.821 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.821488e-02 | 1.740 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.821488e-02 | 1.740 |
| R-HSA-109582 | Hemostasis | 1.679505e-02 | 1.775 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.835414e-02 | 1.736 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.931031e-02 | 1.714 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.348474e-02 | 1.629 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.535027e-02 | 1.596 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.711893e-02 | 1.567 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 2.719835e-02 | 1.565 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 2.719835e-02 | 1.565 |
| R-HSA-2262752 | Cellular responses to stress | 2.998725e-02 | 1.523 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.349578e-02 | 1.475 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.349578e-02 | 1.475 |
| R-HSA-913531 | Interferon Signaling | 3.390262e-02 | 1.470 |
| R-HSA-5693538 | Homology Directed Repair | 3.427425e-02 | 1.465 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 3.610017e-02 | 1.442 |
| R-HSA-422475 | Axon guidance | 3.691627e-02 | 1.433 |
| R-HSA-8865999 | MET activates PTPN11 | 4.492108e-02 | 1.348 |
| R-HSA-9843745 | Adipogenesis | 4.755464e-02 | 1.323 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.385973e-02 | 1.358 |
| R-HSA-4839726 | Chromatin organization | 3.881972e-02 | 1.411 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.430940e-02 | 1.354 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.997450e-02 | 1.398 |
| R-HSA-9930044 | Nuclear RNA decay | 5.057434e-02 | 1.296 |
| R-HSA-9675108 | Nervous system development | 5.249700e-02 | 1.280 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.288976e-02 | 1.277 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.295357e-02 | 1.276 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 5.366181e-02 | 1.270 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 5.366181e-02 | 1.270 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.368626e-02 | 1.270 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.652699e-02 | 1.248 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.652699e-02 | 1.248 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.763116e-02 | 1.239 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.797377e-02 | 1.237 |
| R-HSA-446728 | Cell junction organization | 5.815418e-02 | 1.235 |
| R-HSA-1266738 | Developmental Biology | 5.847436e-02 | 1.233 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 7.090561e-02 | 1.149 |
| R-HSA-9842640 | Signaling by LTK in cancer | 7.941011e-02 | 1.100 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 7.009013e-02 | 1.154 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 6.232308e-02 | 1.205 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 7.941011e-02 | 1.100 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 7.267919e-02 | 1.139 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.392534e-02 | 1.131 |
| R-HSA-165159 | MTOR signalling | 7.794827e-02 | 1.108 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 7.529883e-02 | 1.123 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 7.009013e-02 | 1.154 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 7.009013e-02 | 1.154 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 7.009013e-02 | 1.154 |
| R-HSA-73894 | DNA Repair | 6.241838e-02 | 1.205 |
| R-HSA-9694548 | Maturation of spike protein | 7.267919e-02 | 1.139 |
| R-HSA-73884 | Base Excision Repair | 6.393430e-02 | 1.194 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 7.794827e-02 | 1.108 |
| R-HSA-9683701 | Translation of Structural Proteins | 7.529883e-02 | 1.123 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 6.251426e-02 | 1.204 |
| R-HSA-195721 | Signaling by WNT | 7.434158e-02 | 1.129 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.858344e-02 | 1.164 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.546719e-02 | 1.184 |
| R-HSA-8854214 | TBC/RABGAPs | 8.062677e-02 | 1.094 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.170217e-02 | 1.088 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.276797e-02 | 1.082 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.341333e-02 | 1.079 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 8.783729e-02 | 1.056 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 8.783729e-02 | 1.056 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.618783e-02 | 1.017 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.618783e-02 | 1.017 |
| R-HSA-196025 | Formation of annular gap junctions | 9.618783e-02 | 1.017 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 9.618783e-02 | 1.017 |
| R-HSA-190873 | Gap junction degradation | 1.044624e-01 | 0.981 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.126618e-01 | 0.948 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.288375e-01 | 0.890 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.288375e-01 | 0.890 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.368152e-01 | 0.864 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.368152e-01 | 0.864 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.368152e-01 | 0.864 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.368152e-01 | 0.864 |
| R-HSA-180292 | GAB1 signalosome | 1.906633e-01 | 0.720 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 1.906633e-01 | 0.720 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 1.980785e-01 | 0.703 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.980785e-01 | 0.703 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.980785e-01 | 0.703 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.054262e-01 | 0.687 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.054262e-01 | 0.687 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.054262e-01 | 0.687 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.054262e-01 | 0.687 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.054262e-01 | 0.687 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.054262e-01 | 0.687 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.199216e-01 | 0.658 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.199216e-01 | 0.658 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.270704e-01 | 0.644 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.088512e-01 | 0.963 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 2.481290e-01 | 0.605 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.481290e-01 | 0.605 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.455083e-01 | 0.837 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.906633e-01 | 0.720 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.127070e-01 | 0.672 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.550210e-01 | 0.593 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.054262e-01 | 0.687 |
| R-HSA-6798695 | Neutrophil degranulation | 1.525041e-01 | 0.817 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.756281e-01 | 0.755 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.288375e-01 | 0.890 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.756281e-01 | 0.755 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.268588e-01 | 0.897 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.975031e-01 | 0.704 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.108535e-01 | 0.676 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 8.783729e-02 | 1.056 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.756281e-01 | 0.755 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.518464e-01 | 0.819 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.368152e-01 | 0.864 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.044624e-01 | 0.981 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.175631e-01 | 0.662 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.111144e-01 | 0.675 |
| R-HSA-192814 | vRNA Synthesis | 1.207866e-01 | 0.918 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.288375e-01 | 0.890 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.288375e-01 | 0.890 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.447203e-01 | 0.839 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.906633e-01 | 0.720 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.906633e-01 | 0.720 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 1.906633e-01 | 0.720 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.199216e-01 | 0.658 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.270704e-01 | 0.644 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.906633e-01 | 0.720 |
| R-HSA-3928664 | Ephrin signaling | 1.906633e-01 | 0.720 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.831801e-01 | 0.737 |
| R-HSA-9620244 | Long-term potentiation | 2.481290e-01 | 0.605 |
| R-HSA-5696398 | Nucleotide Excision Repair | 9.399837e-02 | 1.027 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.270704e-01 | 0.644 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.147746e-01 | 0.940 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.550210e-01 | 0.593 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.980785e-01 | 0.703 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.550359e-01 | 0.810 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.784795e-02 | 1.009 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 1.680067e-01 | 0.775 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.756281e-01 | 0.755 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.127070e-01 | 0.672 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.127070e-01 | 0.672 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.411735e-01 | 0.618 |
| R-HSA-9909396 | Circadian clock | 1.562735e-01 | 0.806 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 9.442937e-02 | 1.025 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 9.618783e-02 | 1.017 |
| R-HSA-177929 | Signaling by EGFR | 1.177668e-01 | 0.929 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.756281e-01 | 0.755 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.646801e-01 | 0.783 |
| R-HSA-1226099 | Signaling by FGFR in disease | 1.744275e-01 | 0.758 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.550210e-01 | 0.593 |
| R-HSA-6806834 | Signaling by MET | 1.941821e-01 | 0.712 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 8.783729e-02 | 1.056 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.044624e-01 | 0.981 |
| R-HSA-9683686 | Maturation of spike protein | 1.126618e-01 | 0.948 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.288375e-01 | 0.890 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.368152e-01 | 0.864 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.368152e-01 | 0.864 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.603154e-01 | 0.795 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.680067e-01 | 0.775 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.199216e-01 | 0.658 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.270704e-01 | 0.644 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 2.341542e-01 | 0.630 |
| R-HSA-429947 | Deadenylation of mRNA | 2.411735e-01 | 0.618 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.550210e-01 | 0.593 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.744275e-01 | 0.758 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.126618e-01 | 0.948 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.525535e-01 | 0.817 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.525535e-01 | 0.817 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.603154e-01 | 0.795 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.906633e-01 | 0.720 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.199216e-01 | 0.658 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.341542e-01 | 0.630 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.341542e-01 | 0.630 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.268588e-01 | 0.897 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.680067e-01 | 0.775 |
| R-HSA-9945266 | Differentiation of T cells | 1.680067e-01 | 0.775 |
| R-HSA-112043 | PLC beta mediated events | 1.330101e-01 | 0.876 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.688168e-02 | 1.061 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.222088e-01 | 0.913 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.603154e-01 | 0.795 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.680067e-01 | 0.775 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.831801e-01 | 0.737 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.831801e-01 | 0.737 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.550210e-01 | 0.593 |
| R-HSA-112040 | G-protein mediated events | 1.518464e-01 | 0.819 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.126618e-01 | 0.948 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.550210e-01 | 0.593 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.614533e-01 | 0.792 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.127070e-01 | 0.672 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.127070e-01 | 0.672 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 8.783729e-02 | 1.056 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.447203e-01 | 0.839 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.145535e-01 | 0.941 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.624008e-02 | 1.064 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.044624e-01 | 0.981 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.809768e-01 | 0.742 |
| R-HSA-73887 | Death Receptor Signaling | 2.111144e-01 | 0.675 |
| R-HSA-445144 | Signal transduction by L1 | 2.054262e-01 | 0.687 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.167551e-01 | 0.933 |
| R-HSA-1500931 | Cell-Cell communication | 9.090450e-02 | 1.041 |
| R-HSA-9694631 | Maturation of nucleoprotein | 1.980785e-01 | 0.703 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.270704e-01 | 0.644 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.875629e-01 | 0.727 |
| R-HSA-1643685 | Disease | 2.371725e-01 | 0.625 |
| R-HSA-3000170 | Syndecan interactions | 2.341542e-01 | 0.630 |
| R-HSA-3000157 | Laminin interactions | 2.481290e-01 | 0.605 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.040280e-01 | 0.690 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.016786e-01 | 0.695 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.016786e-01 | 0.695 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.680516e-01 | 0.775 |
| R-HSA-5663205 | Infectious disease | 1.049541e-01 | 0.979 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.695459e-01 | 0.771 |
| R-HSA-2028269 | Signaling by Hippo | 1.831801e-01 | 0.737 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.260153e-01 | 0.900 |
| R-HSA-9679506 | SARS-CoV Infections | 8.518664e-02 | 1.070 |
| R-HSA-109581 | Apoptosis | 2.302645e-01 | 0.638 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.581199e-01 | 0.588 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.615120e-01 | 0.583 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.618504e-01 | 0.582 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.618504e-01 | 0.582 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.618504e-01 | 0.582 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.618504e-01 | 0.582 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 2.618504e-01 | 0.582 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.686175e-01 | 0.571 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.686175e-01 | 0.571 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.686175e-01 | 0.571 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.686175e-01 | 0.571 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.686175e-01 | 0.571 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.735432e-01 | 0.563 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.753230e-01 | 0.560 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.753230e-01 | 0.560 |
| R-HSA-72086 | mRNA Capping | 2.753230e-01 | 0.560 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.753230e-01 | 0.560 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.753230e-01 | 0.560 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.753230e-01 | 0.560 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.753230e-01 | 0.560 |
| R-HSA-597592 | Post-translational protein modification | 2.815496e-01 | 0.550 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.819675e-01 | 0.550 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.819675e-01 | 0.550 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.819675e-01 | 0.550 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.819675e-01 | 0.550 |
| R-HSA-111885 | Opioid Signalling | 2.852529e-01 | 0.545 |
| R-HSA-182971 | EGFR downregulation | 2.885514e-01 | 0.540 |
| R-HSA-9833110 | RSV-host interactions | 2.886407e-01 | 0.540 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.920268e-01 | 0.535 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.950754e-01 | 0.530 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.959974e-01 | 0.529 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.987927e-01 | 0.525 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.987927e-01 | 0.525 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.015399e-01 | 0.521 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.015399e-01 | 0.521 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.015399e-01 | 0.521 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.015399e-01 | 0.521 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.015399e-01 | 0.521 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.015399e-01 | 0.521 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.015399e-01 | 0.521 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.015399e-01 | 0.521 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.015399e-01 | 0.521 |
| R-HSA-390522 | Striated Muscle Contraction | 3.079456e-01 | 0.512 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.079456e-01 | 0.512 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.079456e-01 | 0.512 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.079456e-01 | 0.512 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.089224e-01 | 0.510 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.089224e-01 | 0.510 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.142929e-01 | 0.503 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.142929e-01 | 0.503 |
| R-HSA-5673000 | RAF activation | 3.142929e-01 | 0.503 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.142929e-01 | 0.503 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.142929e-01 | 0.503 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.142929e-01 | 0.503 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.142929e-01 | 0.503 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.142929e-01 | 0.503 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.142929e-01 | 0.503 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.142929e-01 | 0.503 |
| R-HSA-5205647 | Mitophagy | 3.142929e-01 | 0.503 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.205824e-01 | 0.494 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.205824e-01 | 0.494 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.205824e-01 | 0.494 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.205824e-01 | 0.494 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.223835e-01 | 0.492 |
| R-HSA-8853659 | RET signaling | 3.268146e-01 | 0.486 |
| R-HSA-111933 | Calmodulin induced events | 3.268146e-01 | 0.486 |
| R-HSA-111997 | CaM pathway | 3.268146e-01 | 0.486 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.268146e-01 | 0.486 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.268146e-01 | 0.486 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 3.290906e-01 | 0.483 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.329900e-01 | 0.478 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.329900e-01 | 0.478 |
| R-HSA-8875878 | MET promotes cell motility | 3.391091e-01 | 0.470 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.391091e-01 | 0.470 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.391175e-01 | 0.470 |
| R-HSA-5357801 | Programmed Cell Death | 3.418307e-01 | 0.466 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.451725e-01 | 0.462 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.451725e-01 | 0.462 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.451725e-01 | 0.462 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.451725e-01 | 0.462 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.511806e-01 | 0.454 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.511806e-01 | 0.454 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.511806e-01 | 0.454 |
| R-HSA-167169 | HIV Transcription Elongation | 3.511806e-01 | 0.454 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.571339e-01 | 0.447 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.571339e-01 | 0.447 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.571339e-01 | 0.447 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.590308e-01 | 0.445 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.590308e-01 | 0.445 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.630330e-01 | 0.440 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.630330e-01 | 0.440 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.630330e-01 | 0.440 |
| R-HSA-111996 | Ca-dependent events | 3.688783e-01 | 0.433 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.688783e-01 | 0.433 |
| R-HSA-73928 | Depyrimidination | 3.688783e-01 | 0.433 |
| R-HSA-418990 | Adherens junctions interactions | 3.742821e-01 | 0.427 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.746704e-01 | 0.426 |
| R-HSA-69481 | G2/M Checkpoints | 3.754594e-01 | 0.425 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.804096e-01 | 0.420 |
| R-HSA-8951664 | Neddylation | 3.817342e-01 | 0.418 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.852353e-01 | 0.414 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.860965e-01 | 0.413 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.860965e-01 | 0.413 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.860965e-01 | 0.413 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.860965e-01 | 0.413 |
| R-HSA-8953854 | Metabolism of RNA | 3.883965e-01 | 0.411 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.917316e-01 | 0.407 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.917316e-01 | 0.407 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.917316e-01 | 0.407 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.917316e-01 | 0.407 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.917316e-01 | 0.407 |
| R-HSA-9675135 | Diseases of DNA repair | 3.917316e-01 | 0.407 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.973153e-01 | 0.401 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.973153e-01 | 0.401 |
| R-HSA-1483191 | Synthesis of PC | 3.973153e-01 | 0.401 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.990455e-01 | 0.399 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.028481e-01 | 0.395 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.083304e-01 | 0.389 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.083304e-01 | 0.389 |
| R-HSA-73893 | DNA Damage Bypass | 4.083304e-01 | 0.389 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.109726e-01 | 0.386 |
| R-HSA-109704 | PI3K Cascade | 4.137627e-01 | 0.383 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.137627e-01 | 0.383 |
| R-HSA-912446 | Meiotic recombination | 4.191455e-01 | 0.378 |
| R-HSA-72187 | mRNA 3'-end processing | 4.244792e-01 | 0.372 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.244792e-01 | 0.372 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.297643e-01 | 0.367 |
| R-HSA-1221632 | Meiotic synapsis | 4.297643e-01 | 0.367 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.297643e-01 | 0.367 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.297643e-01 | 0.367 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.297643e-01 | 0.367 |
| R-HSA-72649 | Translation initiation complex formation | 4.350011e-01 | 0.362 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.350011e-01 | 0.362 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.401902e-01 | 0.356 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.453319e-01 | 0.351 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.453319e-01 | 0.351 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.453319e-01 | 0.351 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.453319e-01 | 0.351 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.453319e-01 | 0.351 |
| R-HSA-112399 | IRS-mediated signalling | 4.504267e-01 | 0.346 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.504267e-01 | 0.346 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.516353e-01 | 0.345 |
| R-HSA-421270 | Cell-cell junction organization | 4.548722e-01 | 0.342 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.554751e-01 | 0.342 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.604773e-01 | 0.337 |
| R-HSA-186712 | Regulation of beta-cell development | 4.604773e-01 | 0.337 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.654340e-01 | 0.332 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.654340e-01 | 0.332 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.654340e-01 | 0.332 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.654340e-01 | 0.332 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.654340e-01 | 0.332 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.654340e-01 | 0.332 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.703454e-01 | 0.328 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.703454e-01 | 0.328 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.703454e-01 | 0.328 |
| R-HSA-450294 | MAP kinase activation | 4.703454e-01 | 0.328 |
| R-HSA-9707616 | Heme signaling | 4.752119e-01 | 0.323 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.752119e-01 | 0.323 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.800341e-01 | 0.319 |
| R-HSA-9711097 | Cellular response to starvation | 4.818203e-01 | 0.317 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.848122e-01 | 0.314 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.848122e-01 | 0.314 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.848122e-01 | 0.314 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.895468e-01 | 0.310 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.942381e-01 | 0.306 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.988866e-01 | 0.302 |
| R-HSA-196807 | Nicotinate metabolism | 4.988866e-01 | 0.302 |
| R-HSA-167172 | Transcription of the HIV genome | 5.034926e-01 | 0.298 |
| R-HSA-448424 | Interleukin-17 signaling | 5.125789e-01 | 0.290 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.170600e-01 | 0.286 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.170600e-01 | 0.286 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.170600e-01 | 0.286 |
| R-HSA-1280218 | Adaptive Immune System | 5.211854e-01 | 0.283 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.215001e-01 | 0.283 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.215001e-01 | 0.283 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.251444e-01 | 0.280 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.258996e-01 | 0.279 |
| R-HSA-4086398 | Ca2+ pathway | 5.258996e-01 | 0.279 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.258996e-01 | 0.279 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.279457e-01 | 0.277 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.279457e-01 | 0.277 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.302590e-01 | 0.276 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.302590e-01 | 0.276 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.335151e-01 | 0.273 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.345786e-01 | 0.272 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.345786e-01 | 0.272 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.388587e-01 | 0.269 |
| R-HSA-2559583 | Cellular Senescence | 5.472428e-01 | 0.262 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.473019e-01 | 0.262 |
| R-HSA-4086400 | PCP/CE pathway | 5.473019e-01 | 0.262 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.473019e-01 | 0.262 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.514658e-01 | 0.258 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.555917e-01 | 0.255 |
| R-HSA-977225 | Amyloid fiber formation | 5.596798e-01 | 0.252 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.596798e-01 | 0.252 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.637306e-01 | 0.249 |
| R-HSA-392499 | Metabolism of proteins | 5.656501e-01 | 0.247 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.677443e-01 | 0.246 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.717214e-01 | 0.243 |
| R-HSA-1500620 | Meiosis | 5.756622e-01 | 0.240 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.764470e-01 | 0.239 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.795669e-01 | 0.237 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.841716e-01 | 0.233 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.892639e-01 | 0.230 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.985616e-01 | 0.223 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.993105e-01 | 0.222 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.022569e-01 | 0.220 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.095466e-01 | 0.215 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.095466e-01 | 0.215 |
| R-HSA-72172 | mRNA Splicing | 6.116098e-01 | 0.214 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.167036e-01 | 0.210 |
| R-HSA-1474290 | Collagen formation | 6.167036e-01 | 0.210 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.202331e-01 | 0.207 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.237303e-01 | 0.205 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.306290e-01 | 0.200 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.340311e-01 | 0.198 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.340311e-01 | 0.198 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.340311e-01 | 0.198 |
| R-HSA-190236 | Signaling by FGFR | 6.340311e-01 | 0.198 |
| R-HSA-422356 | Regulation of insulin secretion | 6.340311e-01 | 0.198 |
| R-HSA-3214847 | HATs acetylate histones | 6.374020e-01 | 0.196 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.440517e-01 | 0.191 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.473310e-01 | 0.189 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.473310e-01 | 0.189 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.694608e-01 | 0.174 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.694608e-01 | 0.174 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.694608e-01 | 0.174 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.694608e-01 | 0.174 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.694608e-01 | 0.174 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.725075e-01 | 0.172 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.814813e-01 | 0.167 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.824494e-01 | 0.166 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.844179e-01 | 0.165 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.844179e-01 | 0.165 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.873277e-01 | 0.163 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.930675e-01 | 0.159 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.987026e-01 | 0.156 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.987026e-01 | 0.156 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.014815e-01 | 0.154 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.042349e-01 | 0.152 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.069632e-01 | 0.151 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.069632e-01 | 0.151 |
| R-HSA-68875 | Mitotic Prophase | 7.096664e-01 | 0.149 |
| R-HSA-3371556 | Cellular response to heat stress | 7.123448e-01 | 0.147 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.149987e-01 | 0.146 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.149987e-01 | 0.146 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.202338e-01 | 0.143 |
| R-HSA-5688426 | Deubiquitination | 7.209472e-01 | 0.142 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.228080e-01 | 0.141 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.253734e-01 | 0.139 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.253734e-01 | 0.139 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.253734e-01 | 0.139 |
| R-HSA-114608 | Platelet degranulation | 7.304191e-01 | 0.136 |
| R-HSA-1474165 | Reproduction | 7.402360e-01 | 0.131 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.473649e-01 | 0.126 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.565687e-01 | 0.121 |
| R-HSA-163685 | Integration of energy metabolism | 7.565687e-01 | 0.121 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.718810e-01 | 0.112 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.718810e-01 | 0.112 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.739889e-01 | 0.111 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.785901e-01 | 0.109 |
| R-HSA-166520 | Signaling by NTRKs | 7.842418e-01 | 0.106 |
| R-HSA-9758941 | Gastrulation | 7.862362e-01 | 0.104 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.890890e-01 | 0.103 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.921103e-01 | 0.101 |
| R-HSA-1989781 | PPARA activates gene expression | 7.978241e-01 | 0.098 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.978241e-01 | 0.098 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.015463e-01 | 0.096 |
| R-HSA-162587 | HIV Life Cycle | 8.015463e-01 | 0.096 |
| R-HSA-877300 | Interferon gamma signaling | 8.052005e-01 | 0.094 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.070024e-01 | 0.093 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.257636e-01 | 0.083 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.305580e-01 | 0.081 |
| R-HSA-168255 | Influenza Infection | 8.397573e-01 | 0.076 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.526341e-01 | 0.069 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.532142e-01 | 0.069 |
| R-HSA-983712 | Ion channel transport | 8.539998e-01 | 0.069 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.718508e-01 | 0.060 |
| R-HSA-6805567 | Keratinization | 8.765405e-01 | 0.057 |
| R-HSA-168249 | Innate Immune System | 8.807033e-01 | 0.055 |
| R-HSA-397014 | Muscle contraction | 8.832573e-01 | 0.054 |
| R-HSA-162906 | HIV Infection | 8.985031e-01 | 0.046 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.013060e-01 | 0.045 |
| R-HSA-72312 | rRNA processing | 9.031318e-01 | 0.044 |
| R-HSA-418594 | G alpha (i) signalling events | 9.064517e-01 | 0.043 |
| R-HSA-8939211 | ESR-mediated signaling | 9.075508e-01 | 0.042 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.075508e-01 | 0.042 |
| R-HSA-157118 | Signaling by NOTCH | 9.101055e-01 | 0.041 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.274974e-01 | 0.033 |
| R-HSA-416476 | G alpha (q) signalling events | 9.281725e-01 | 0.032 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.336276e-01 | 0.030 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.345898e-01 | 0.029 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.393108e-01 | 0.027 |
| R-HSA-168256 | Immune System | 9.448449e-01 | 0.025 |
| R-HSA-1483257 | Phospholipid metabolism | 9.462711e-01 | 0.024 |
| R-HSA-8957322 | Metabolism of steroids | 9.590706e-01 | 0.018 |
| R-HSA-1474244 | Extracellular matrix organization | 9.616753e-01 | 0.017 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.716358e-01 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.719016e-01 | 0.012 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.767272e-01 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 9.788262e-01 | 0.009 |
| R-HSA-72766 | Translation | 9.849257e-01 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 9.886159e-01 | 0.005 |
| R-HSA-449147 | Signaling by Interleukins | 9.976648e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.999258e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999923e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1E |
0.810 | 0.520 | -3 | 0.666 |
CK1D |
0.804 | 0.514 | -3 | 0.680 |
CK1G1 |
0.802 | 0.489 | -3 | 0.646 |
CK1A2 |
0.801 | 0.510 | -3 | 0.680 |
COT |
0.787 | 0.209 | 2 | 0.860 |
CK1A |
0.787 | 0.450 | -3 | 0.690 |
CLK3 |
0.779 | 0.135 | 1 | 0.837 |
KIS |
0.779 | 0.166 | 1 | 0.689 |
MTOR |
0.774 | 0.190 | 1 | 0.811 |
GRK1 |
0.771 | 0.206 | -2 | 0.803 |
SRPK1 |
0.767 | 0.045 | -3 | 0.201 |
CLK2 |
0.767 | 0.111 | -3 | 0.198 |
CDC7 |
0.766 | 0.099 | 1 | 0.838 |
ATR |
0.765 | 0.125 | 1 | 0.903 |
IKKB |
0.764 | 0.038 | -2 | 0.724 |
CK1G3 |
0.764 | 0.433 | -3 | 0.688 |
MOS |
0.763 | 0.089 | 1 | 0.839 |
PIM3 |
0.762 | 0.017 | -3 | 0.233 |
GRK5 |
0.762 | 0.174 | -3 | 0.353 |
CDKL1 |
0.762 | 0.040 | -3 | 0.211 |
NDR2 |
0.761 | 0.035 | -3 | 0.224 |
GRK7 |
0.761 | 0.183 | 1 | 0.797 |
DSTYK |
0.761 | 0.024 | 2 | 0.843 |
SRPK2 |
0.760 | 0.020 | -3 | 0.173 |
MST4 |
0.759 | 0.101 | 2 | 0.825 |
PRPK |
0.759 | 0.026 | -1 | 0.664 |
RSK2 |
0.759 | 0.011 | -3 | 0.179 |
SKMLCK |
0.759 | 0.076 | -2 | 0.873 |
RAF1 |
0.759 | 0.044 | 1 | 0.868 |
HIPK4 |
0.759 | 0.067 | 1 | 0.801 |
BMPR1B |
0.758 | 0.178 | 1 | 0.809 |
SRPK3 |
0.758 | 0.036 | -3 | 0.211 |
CDKL5 |
0.758 | 0.036 | -3 | 0.198 |
MLK1 |
0.757 | 0.089 | 2 | 0.783 |
GRK4 |
0.756 | 0.153 | -2 | 0.814 |
PRKD1 |
0.756 | 0.006 | -3 | 0.172 |
GRK6 |
0.756 | 0.167 | 1 | 0.857 |
P90RSK |
0.755 | -0.006 | -3 | 0.180 |
GCN2 |
0.755 | -0.038 | 2 | 0.729 |
PDHK4 |
0.754 | -0.055 | 1 | 0.870 |
CLK4 |
0.754 | 0.053 | -3 | 0.211 |
PKN2 |
0.754 | 0.025 | -3 | 0.227 |
PIM1 |
0.753 | 0.017 | -3 | 0.229 |
PKACB |
0.753 | 0.058 | -2 | 0.690 |
CAMK1B |
0.753 | -0.022 | -3 | 0.230 |
ICK |
0.752 | 0.052 | -3 | 0.220 |
ERK5 |
0.752 | 0.030 | 1 | 0.809 |
TBK1 |
0.752 | -0.004 | 1 | 0.772 |
BMPR2 |
0.752 | 0.027 | -2 | 0.840 |
NLK |
0.751 | 0.009 | 1 | 0.838 |
IKKA |
0.751 | 0.031 | -2 | 0.719 |
PRKD2 |
0.751 | -0.023 | -3 | 0.153 |
MAPKAPK2 |
0.751 | -0.032 | -3 | 0.160 |
DYRK2 |
0.751 | 0.057 | 1 | 0.703 |
RSK4 |
0.750 | 0.019 | -3 | 0.183 |
NUAK2 |
0.750 | -0.002 | -3 | 0.229 |
AURC |
0.750 | 0.058 | -2 | 0.693 |
IKKE |
0.750 | -0.018 | 1 | 0.769 |
PKACG |
0.749 | 0.028 | -2 | 0.735 |
NEK6 |
0.749 | -0.044 | -2 | 0.810 |
CDK1 |
0.749 | 0.078 | 1 | 0.634 |
CHAK2 |
0.749 | 0.010 | -1 | 0.584 |
NDR1 |
0.749 | -0.016 | -3 | 0.211 |
RIPK3 |
0.749 | 0.008 | 3 | 0.629 |
ATM |
0.749 | 0.073 | 1 | 0.865 |
RSK3 |
0.749 | -0.018 | -3 | 0.166 |
PKCD |
0.749 | 0.043 | 2 | 0.762 |
TGFBR2 |
0.749 | -0.000 | -2 | 0.790 |
BCKDK |
0.748 | -0.025 | -1 | 0.659 |
PRKX |
0.748 | 0.035 | -3 | 0.180 |
AKT2 |
0.748 | 0.018 | -3 | 0.171 |
WNK1 |
0.748 | -0.005 | -2 | 0.854 |
CLK1 |
0.748 | 0.026 | -3 | 0.176 |
PKCB |
0.747 | 0.044 | 2 | 0.717 |
PKN3 |
0.747 | -0.035 | -3 | 0.204 |
ULK2 |
0.747 | -0.075 | 2 | 0.726 |
CAMK2G |
0.747 | -0.042 | 2 | 0.735 |
GRK3 |
0.747 | 0.171 | -2 | 0.699 |
HIPK2 |
0.747 | 0.070 | 1 | 0.609 |
MSK2 |
0.747 | -0.002 | -3 | 0.200 |
CDK18 |
0.747 | 0.085 | 1 | 0.599 |
PKCG |
0.746 | 0.056 | 2 | 0.713 |
PKCA |
0.746 | 0.069 | 2 | 0.706 |
PDHK1 |
0.746 | -0.105 | 1 | 0.858 |
NEK7 |
0.746 | -0.064 | -3 | 0.242 |
NIK |
0.746 | -0.010 | -3 | 0.237 |
GRK2 |
0.745 | 0.128 | -2 | 0.728 |
DAPK2 |
0.745 | 0.008 | -3 | 0.226 |
DLK |
0.745 | 0.071 | 1 | 0.866 |
MLK3 |
0.745 | 0.032 | 2 | 0.716 |
CAMLCK |
0.745 | 0.003 | -2 | 0.848 |
CDK8 |
0.744 | 0.038 | 1 | 0.662 |
MSK1 |
0.744 | 0.017 | -3 | 0.187 |
DNAPK |
0.744 | 0.109 | 1 | 0.822 |
CDK19 |
0.744 | 0.050 | 1 | 0.623 |
MAPKAPK3 |
0.743 | -0.073 | -3 | 0.162 |
MARK4 |
0.743 | 0.023 | 4 | 0.784 |
CAMK2D |
0.743 | -0.044 | -3 | 0.195 |
CAMK2A |
0.742 | -0.017 | 2 | 0.733 |
FAM20C |
0.742 | 0.022 | 2 | 0.519 |
MLK2 |
0.741 | 0.001 | 2 | 0.778 |
CAMK2B |
0.741 | -0.006 | 2 | 0.719 |
ACVR2A |
0.741 | 0.103 | -2 | 0.769 |
CK1G2 |
0.741 | 0.361 | -3 | 0.669 |
TLK2 |
0.741 | 0.069 | 1 | 0.852 |
P70S6KB |
0.741 | -0.040 | -3 | 0.193 |
HUNK |
0.741 | -0.057 | 2 | 0.761 |
MLK4 |
0.741 | 0.063 | 2 | 0.696 |
MASTL |
0.741 | -0.041 | -2 | 0.775 |
HIPK1 |
0.740 | 0.054 | 1 | 0.717 |
JNK3 |
0.740 | 0.056 | 1 | 0.649 |
PAK1 |
0.740 | 0.008 | -2 | 0.806 |
IRE1 |
0.740 | 0.010 | 1 | 0.821 |
ACVR2B |
0.739 | 0.084 | -2 | 0.781 |
TTBK2 |
0.739 | -0.010 | 2 | 0.624 |
MNK2 |
0.739 | 0.007 | -2 | 0.783 |
SMG1 |
0.739 | 0.039 | 1 | 0.868 |
MYLK4 |
0.739 | 0.020 | -2 | 0.792 |
MST3 |
0.739 | 0.165 | 2 | 0.807 |
CDK5 |
0.738 | 0.068 | 1 | 0.685 |
TGFBR1 |
0.738 | 0.049 | -2 | 0.810 |
ULK1 |
0.738 | -0.108 | -3 | 0.216 |
ALK4 |
0.738 | 0.056 | -2 | 0.831 |
AMPKA1 |
0.738 | -0.037 | -3 | 0.218 |
JNK2 |
0.738 | 0.062 | 1 | 0.621 |
NIM1 |
0.738 | 0.070 | 3 | 0.654 |
MEKK3 |
0.737 | 0.165 | 1 | 0.844 |
P38B |
0.737 | 0.079 | 1 | 0.636 |
SGK3 |
0.737 | 0.013 | -3 | 0.181 |
NEK9 |
0.737 | -0.068 | 2 | 0.779 |
MNK1 |
0.737 | 0.006 | -2 | 0.782 |
YSK4 |
0.736 | 0.017 | 1 | 0.812 |
DYRK4 |
0.736 | 0.057 | 1 | 0.620 |
P38A |
0.736 | 0.069 | 1 | 0.706 |
LATS2 |
0.736 | -0.066 | -5 | 0.669 |
CDK13 |
0.736 | 0.031 | 1 | 0.641 |
PKCZ |
0.735 | 0.005 | 2 | 0.733 |
PKCH |
0.735 | 0.004 | 2 | 0.689 |
AMPKA2 |
0.735 | -0.043 | -3 | 0.199 |
ERK1 |
0.735 | 0.056 | 1 | 0.626 |
LATS1 |
0.734 | -0.009 | -3 | 0.211 |
P38G |
0.734 | 0.058 | 1 | 0.546 |
PRKD3 |
0.734 | -0.055 | -3 | 0.162 |
BMPR1A |
0.734 | 0.115 | 1 | 0.781 |
CDK17 |
0.734 | 0.058 | 1 | 0.548 |
MEK1 |
0.734 | 0.106 | 2 | 0.782 |
PKACA |
0.734 | 0.021 | -2 | 0.643 |
AURA |
0.733 | 0.050 | -2 | 0.679 |
RIPK1 |
0.733 | -0.059 | 1 | 0.852 |
PAK3 |
0.733 | -0.022 | -2 | 0.791 |
CAMK4 |
0.733 | -0.069 | -3 | 0.219 |
ANKRD3 |
0.733 | -0.065 | 1 | 0.881 |
QSK |
0.733 | 0.018 | 4 | 0.755 |
TSSK2 |
0.733 | -0.031 | -5 | 0.851 |
DYRK1A |
0.732 | 0.012 | 1 | 0.741 |
ALK2 |
0.732 | 0.051 | -2 | 0.817 |
MAK |
0.732 | 0.091 | -2 | 0.840 |
PASK |
0.732 | 0.050 | -3 | 0.259 |
DRAK1 |
0.732 | 0.024 | 1 | 0.819 |
CDK3 |
0.732 | 0.052 | 1 | 0.563 |
MPSK1 |
0.732 | 0.123 | 1 | 0.761 |
AKT1 |
0.731 | 0.013 | -3 | 0.169 |
PKG2 |
0.731 | -0.001 | -2 | 0.679 |
TSSK1 |
0.731 | -0.037 | -3 | 0.213 |
PRP4 |
0.731 | -0.007 | -3 | 0.209 |
TAO3 |
0.731 | 0.113 | 1 | 0.834 |
QIK |
0.731 | -0.016 | -3 | 0.214 |
CDK12 |
0.731 | 0.029 | 1 | 0.619 |
AURB |
0.730 | 0.023 | -2 | 0.688 |
PHKG1 |
0.730 | -0.057 | -3 | 0.213 |
CDK14 |
0.730 | 0.057 | 1 | 0.647 |
CDK7 |
0.730 | 0.006 | 1 | 0.665 |
DYRK3 |
0.730 | 0.031 | 1 | 0.722 |
P38D |
0.730 | 0.069 | 1 | 0.560 |
TLK1 |
0.730 | 0.056 | -2 | 0.813 |
PKR |
0.730 | 0.001 | 1 | 0.860 |
SIK |
0.730 | -0.006 | -3 | 0.185 |
CDK10 |
0.730 | 0.055 | 1 | 0.631 |
MEKK2 |
0.730 | 0.144 | 2 | 0.757 |
PLK1 |
0.728 | -0.057 | -2 | 0.747 |
CDK2 |
0.728 | 0.014 | 1 | 0.720 |
DCAMKL1 |
0.728 | -0.027 | -3 | 0.182 |
HIPK3 |
0.728 | 0.017 | 1 | 0.723 |
PAK2 |
0.727 | -0.014 | -2 | 0.792 |
PAK6 |
0.727 | -0.013 | -2 | 0.732 |
WNK3 |
0.727 | -0.166 | 1 | 0.847 |
AKT3 |
0.727 | 0.012 | -3 | 0.151 |
PKCE |
0.727 | 0.037 | 2 | 0.693 |
VRK2 |
0.727 | -0.053 | 1 | 0.881 |
BRSK1 |
0.726 | -0.065 | -3 | 0.182 |
PIM2 |
0.726 | -0.033 | -3 | 0.176 |
NEK2 |
0.726 | -0.071 | 2 | 0.742 |
IRE2 |
0.726 | -0.035 | 2 | 0.703 |
CDK16 |
0.726 | 0.061 | 1 | 0.563 |
MARK3 |
0.726 | 0.003 | 4 | 0.700 |
SGK1 |
0.726 | 0.010 | -3 | 0.149 |
GSK3A |
0.726 | 0.056 | 4 | 0.490 |
ZAK |
0.726 | 0.033 | 1 | 0.818 |
CAMK1G |
0.725 | -0.058 | -3 | 0.188 |
NUAK1 |
0.725 | -0.080 | -3 | 0.179 |
CDK9 |
0.725 | -0.002 | 1 | 0.652 |
GCK |
0.725 | 0.128 | 1 | 0.848 |
MEK5 |
0.725 | 0.026 | 2 | 0.774 |
DYRK1B |
0.724 | 0.018 | 1 | 0.654 |
PKCT |
0.724 | 0.006 | 2 | 0.701 |
JNK1 |
0.724 | 0.057 | 1 | 0.599 |
YANK3 |
0.723 | 0.139 | 2 | 0.380 |
ERK2 |
0.723 | 0.012 | 1 | 0.682 |
CHAK1 |
0.722 | -0.082 | 2 | 0.689 |
HPK1 |
0.721 | 0.127 | 1 | 0.842 |
EEF2K |
0.721 | 0.089 | 3 | 0.776 |
MAPKAPK5 |
0.721 | -0.122 | -3 | 0.160 |
GSK3B |
0.721 | 0.037 | 4 | 0.484 |
BRSK2 |
0.721 | -0.083 | -3 | 0.186 |
NEK11 |
0.721 | 0.067 | 1 | 0.831 |
MEKK1 |
0.720 | -0.024 | 1 | 0.838 |
PLK3 |
0.720 | -0.080 | 2 | 0.707 |
MELK |
0.719 | -0.114 | -3 | 0.175 |
PERK |
0.719 | -0.056 | -2 | 0.807 |
PKCI |
0.719 | -0.001 | 2 | 0.705 |
NEK5 |
0.719 | -0.029 | 1 | 0.864 |
BRAF |
0.719 | -0.044 | -4 | 0.798 |
MST2 |
0.719 | 0.068 | 1 | 0.849 |
TNIK |
0.718 | 0.100 | 3 | 0.812 |
CK2A2 |
0.718 | 0.049 | 1 | 0.667 |
MARK2 |
0.718 | -0.020 | 4 | 0.663 |
SMMLCK |
0.718 | -0.028 | -3 | 0.206 |
PLK4 |
0.717 | -0.012 | 2 | 0.562 |
DAPK3 |
0.717 | 0.017 | -3 | 0.215 |
KHS2 |
0.717 | 0.124 | 1 | 0.846 |
DAPK1 |
0.717 | 0.025 | -3 | 0.226 |
GAK |
0.716 | 0.089 | 1 | 0.820 |
PINK1 |
0.716 | -0.119 | 1 | 0.811 |
MARK1 |
0.716 | -0.037 | 4 | 0.725 |
CHK1 |
0.716 | -0.107 | -3 | 0.157 |
MINK |
0.715 | 0.101 | 1 | 0.839 |
CAMK1D |
0.714 | -0.066 | -3 | 0.148 |
KHS1 |
0.714 | 0.101 | 1 | 0.830 |
HRI |
0.714 | -0.122 | -2 | 0.808 |
HGK |
0.714 | 0.062 | 3 | 0.795 |
CK2A1 |
0.714 | 0.062 | 1 | 0.653 |
WNK4 |
0.713 | -0.063 | -2 | 0.841 |
MOK |
0.713 | 0.038 | 1 | 0.737 |
SNRK |
0.713 | -0.143 | 2 | 0.625 |
P70S6K |
0.713 | -0.079 | -3 | 0.155 |
DCAMKL2 |
0.713 | -0.072 | -3 | 0.182 |
MAP3K15 |
0.713 | 0.082 | 1 | 0.804 |
CHK2 |
0.712 | -0.059 | -3 | 0.143 |
TAK1 |
0.712 | 0.064 | 1 | 0.856 |
PLK2 |
0.712 | -0.026 | -3 | 0.241 |
PHKG2 |
0.712 | -0.076 | -3 | 0.191 |
SBK |
0.712 | -0.034 | -3 | 0.116 |
MEKK6 |
0.711 | 0.033 | 1 | 0.837 |
NEK8 |
0.711 | -0.043 | 2 | 0.767 |
TAO2 |
0.711 | -0.004 | 2 | 0.795 |
TTBK1 |
0.711 | -0.069 | 2 | 0.554 |
LKB1 |
0.710 | -0.039 | -3 | 0.210 |
CAMKK1 |
0.710 | -0.069 | -2 | 0.711 |
PAK5 |
0.710 | -0.023 | -2 | 0.679 |
ERK7 |
0.710 | -0.000 | 2 | 0.509 |
IRAK4 |
0.710 | -0.076 | 1 | 0.838 |
PDK1 |
0.709 | -0.012 | 1 | 0.816 |
PKN1 |
0.709 | -0.052 | -3 | 0.161 |
SSTK |
0.707 | -0.056 | 4 | 0.759 |
CAMKK2 |
0.706 | -0.076 | -2 | 0.716 |
ROCK2 |
0.706 | 0.007 | -3 | 0.199 |
CDK6 |
0.706 | 0.019 | 1 | 0.621 |
NEK4 |
0.706 | -0.044 | 1 | 0.840 |
MST1 |
0.705 | 0.011 | 1 | 0.837 |
MRCKB |
0.705 | -0.018 | -3 | 0.175 |
PAK4 |
0.704 | -0.021 | -2 | 0.694 |
CAMK1A |
0.704 | -0.061 | -3 | 0.141 |
OSR1 |
0.703 | 0.062 | 2 | 0.768 |
SLK |
0.703 | -0.034 | -2 | 0.670 |
LRRK2 |
0.703 | -0.041 | 2 | 0.775 |
MRCKA |
0.703 | -0.026 | -3 | 0.179 |
NEK1 |
0.700 | -0.058 | 1 | 0.840 |
YSK1 |
0.700 | 0.025 | 2 | 0.760 |
DMPK1 |
0.700 | 0.009 | -3 | 0.193 |
LOK |
0.700 | -0.050 | -2 | 0.712 |
CDK4 |
0.699 | 0.003 | 1 | 0.604 |
VRK1 |
0.699 | -0.051 | 2 | 0.801 |
STK33 |
0.699 | -0.059 | 2 | 0.569 |
BUB1 |
0.699 | -0.003 | -5 | 0.784 |
YANK2 |
0.698 | 0.150 | 2 | 0.394 |
IRAK1 |
0.696 | -0.178 | -1 | 0.526 |
MAP2K6_TYR |
0.695 | 0.216 | -1 | 0.698 |
HASPIN |
0.694 | 0.002 | -1 | 0.490 |
ROCK1 |
0.694 | -0.008 | -3 | 0.181 |
TTK |
0.694 | 0.050 | -2 | 0.789 |
PDHK4_TYR |
0.694 | 0.176 | 2 | 0.840 |
PBK |
0.693 | -0.019 | 1 | 0.730 |
PDHK3_TYR |
0.692 | 0.090 | 4 | 0.888 |
MAP2K4_TYR |
0.692 | 0.164 | -1 | 0.699 |
MYO3B |
0.691 | 0.026 | 2 | 0.759 |
ALPHAK3 |
0.691 | 0.053 | -1 | 0.571 |
BMPR2_TYR |
0.690 | 0.086 | -1 | 0.685 |
PDHK1_TYR |
0.690 | 0.134 | -1 | 0.675 |
CRIK |
0.690 | -0.034 | -3 | 0.161 |
PKG1 |
0.688 | -0.048 | -2 | 0.588 |
MYO3A |
0.687 | 0.033 | 1 | 0.827 |
MEK2 |
0.687 | -0.129 | 2 | 0.740 |
RIPK2 |
0.687 | -0.160 | 1 | 0.775 |
TESK1_TYR |
0.685 | 0.004 | 3 | 0.795 |
PKMYT1_TYR |
0.684 | 0.069 | 3 | 0.754 |
MAP2K7_TYR |
0.684 | 0.027 | 2 | 0.793 |
ASK1 |
0.682 | -0.023 | 1 | 0.785 |
NEK3 |
0.682 | -0.109 | 1 | 0.798 |
TAO1 |
0.681 | -0.035 | 1 | 0.770 |
PINK1_TYR |
0.678 | -0.031 | 1 | 0.849 |
FGR |
0.677 | 0.057 | 1 | 0.855 |
EPHA6 |
0.676 | -0.015 | -1 | 0.611 |
LIMK2_TYR |
0.676 | -0.048 | -3 | 0.206 |
EPHB4 |
0.673 | -0.016 | -1 | 0.588 |
ABL2 |
0.673 | 0.043 | -1 | 0.573 |
RET |
0.673 | -0.059 | 1 | 0.843 |
STLK3 |
0.672 | -0.063 | 1 | 0.795 |
TXK |
0.672 | 0.053 | 1 | 0.831 |
ABL1 |
0.671 | 0.045 | -1 | 0.565 |
SYK |
0.671 | 0.118 | -1 | 0.575 |
CSF1R |
0.670 | -0.006 | 3 | 0.669 |
FLT1 |
0.669 | 0.046 | -1 | 0.616 |
LIMK1_TYR |
0.669 | -0.113 | 2 | 0.777 |
TYK2 |
0.668 | -0.080 | 1 | 0.836 |
JAK2 |
0.668 | -0.056 | 1 | 0.833 |
MST1R |
0.668 | -0.079 | 3 | 0.699 |
KIT |
0.668 | 0.018 | 3 | 0.669 |
JAK3 |
0.667 | -0.037 | 1 | 0.818 |
BIKE |
0.667 | -0.054 | 1 | 0.676 |
ROS1 |
0.667 | -0.065 | 3 | 0.636 |
FER |
0.666 | -0.048 | 1 | 0.869 |
MET |
0.665 | 0.031 | 3 | 0.662 |
EPHA4 |
0.665 | -0.041 | 2 | 0.725 |
KDR |
0.665 | -0.011 | 3 | 0.626 |
TYRO3 |
0.665 | -0.088 | 3 | 0.672 |
FYN |
0.664 | 0.026 | -1 | 0.582 |
TNNI3K_TYR |
0.664 | -0.012 | 1 | 0.827 |
LCK |
0.664 | -0.014 | -1 | 0.591 |
YES1 |
0.663 | -0.047 | -1 | 0.605 |
INSRR |
0.663 | -0.040 | 3 | 0.599 |
PTK2 |
0.663 | 0.067 | -1 | 0.592 |
SRMS |
0.663 | -0.049 | 1 | 0.862 |
BLK |
0.662 | -0.004 | -1 | 0.594 |
HCK |
0.662 | -0.057 | -1 | 0.590 |
DDR1 |
0.662 | -0.135 | 4 | 0.820 |
BMX |
0.662 | -0.007 | -1 | 0.482 |
ITK |
0.661 | -0.047 | -1 | 0.560 |
ZAP70 |
0.661 | 0.133 | -1 | 0.530 |
EPHB1 |
0.659 | -0.084 | 1 | 0.867 |
NEK10_TYR |
0.659 | -0.063 | 1 | 0.727 |
WEE1_TYR |
0.659 | -0.023 | -1 | 0.527 |
EPHB2 |
0.658 | -0.060 | -1 | 0.562 |
EPHB3 |
0.658 | -0.075 | -1 | 0.566 |
FLT3 |
0.657 | -0.065 | 3 | 0.677 |
JAK1 |
0.657 | -0.047 | 1 | 0.785 |
TNK2 |
0.657 | -0.075 | 3 | 0.623 |
FGFR2 |
0.657 | -0.096 | 3 | 0.659 |
MATK |
0.656 | -0.007 | -1 | 0.508 |
ERBB2 |
0.655 | -0.033 | 1 | 0.787 |
TEC |
0.653 | -0.073 | -1 | 0.479 |
PDGFRB |
0.653 | -0.134 | 3 | 0.671 |
MERTK |
0.653 | -0.067 | 3 | 0.656 |
FRK |
0.653 | -0.044 | -1 | 0.575 |
TNK1 |
0.653 | -0.098 | 3 | 0.662 |
AAK1 |
0.652 | -0.023 | 1 | 0.568 |
FGFR3 |
0.652 | -0.057 | 3 | 0.627 |
EPHA3 |
0.651 | -0.082 | 2 | 0.694 |
EPHA7 |
0.651 | -0.081 | 2 | 0.718 |
BTK |
0.651 | -0.135 | -1 | 0.518 |
NTRK1 |
0.650 | -0.124 | -1 | 0.609 |
SRC |
0.650 | -0.027 | -1 | 0.576 |
LYN |
0.649 | -0.055 | 3 | 0.595 |
EGFR |
0.649 | -0.027 | 1 | 0.698 |
FGFR4 |
0.648 | -0.020 | -1 | 0.549 |
PTK6 |
0.648 | -0.150 | -1 | 0.501 |
NTRK3 |
0.648 | -0.090 | -1 | 0.573 |
FLT4 |
0.647 | -0.102 | 3 | 0.629 |
EPHA5 |
0.647 | -0.060 | 2 | 0.711 |
EPHA8 |
0.646 | -0.062 | -1 | 0.559 |
FGFR1 |
0.646 | -0.140 | 3 | 0.618 |
ERBB4 |
0.646 | 0.041 | 1 | 0.712 |
INSR |
0.645 | -0.096 | 3 | 0.594 |
PDGFRA |
0.645 | -0.175 | 3 | 0.669 |
CSK |
0.645 | -0.060 | 2 | 0.720 |
TEK |
0.645 | -0.160 | 3 | 0.589 |
AXL |
0.645 | -0.142 | 3 | 0.639 |
PTK2B |
0.645 | -0.054 | -1 | 0.517 |
EPHA1 |
0.644 | -0.119 | 3 | 0.645 |
DDR2 |
0.643 | -0.095 | 3 | 0.576 |
ALK |
0.642 | -0.148 | 3 | 0.556 |
LTK |
0.641 | -0.143 | 3 | 0.596 |
NTRK2 |
0.641 | -0.167 | 3 | 0.614 |
EPHA2 |
0.638 | -0.072 | -1 | 0.541 |
IGF1R |
0.633 | -0.080 | 3 | 0.526 |
MUSK |
0.629 | -0.115 | 1 | 0.692 |
FES |
0.622 | -0.067 | -1 | 0.465 |