Motif 435 (n=216)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S643 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NC98 | CCDC88B | S1380 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| O00401 | WASL | S19 | ochoa | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828, ECO:0000269|PubMed:9422512}. |
| O14795 | UNC13B | S301 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O15049 | N4BP3 | S148 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15055 | PER2 | S665 | psp | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O43166 | SIPA1L1 | S1393 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O60269 | GPRIN2 | S27 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
| O60271 | SPAG9 | S733 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60503 | ADCY9 | S691 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60941 | DTNB | S564 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75121 | MFAP3L | S307 | ochoa | Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) | May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}. |
| O75145 | PPFIA3 | S508 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75460 | ERN1 | S551 | ochoa | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:21317875, PubMed:24508390). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:21317875, PubMed:24508390). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:19328063, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:30118681, ECO:0000269|PubMed:36739529, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}. |
| O75976 | CPD | S1035 | ochoa | Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) | None |
| O94806 | PRKD3 | S216 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94832 | MYO1D | S971 | ochoa | Unconventional myosin-Id | Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}. |
| O94929 | ABLIM3 | S563 | ochoa | Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| O95239 | KIF4A | S1126 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| P04049 | RAF1 | S624 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04920 | SLC4A2 | S446 | ochoa | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
| P05023 | ATP1A1 | S217 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05771 | PRKCB | S149 | ochoa | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P09525 | ANXA4 | S154 | ochoa | Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}. |
| P10398 | ARAF | S585 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P10586 | PTPRF | S1305 | ochoa | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| P13637 | ATP1A3 | S207 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P17252 | PRKCA | S149 | ochoa | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P20648 | ATP4A | S228 | ochoa | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) | The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250|UniProtKB:P09626, ECO:0000250|UniProtKB:P19156, ECO:0000250|UniProtKB:Q64436}. |
| P21709 | EPHA1 | S906 | ochoa | Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}. |
| P21796 | VDAC1 | S241 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P21860 | ERBB3 | S1315 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P23588 | EIF4B | S445 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P25054 | APC | S963 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25054 | APC | S1864 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26045 | PTPN3 | S439 | ochoa | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P32004 | L1CAM | S1194 | ochoa | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P33552 | CKS2 | S51 | ochoa | Cyclin-dependent kinases regulatory subunit 2 (CKS-2) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
| P39880 | CUX1 | S1458 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41162 | ETV3 | S173 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P41743 | PRKCI | S226 | ochoa|psp | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P42684 | ABL2 | S634 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P42694 | HELZ | S1741 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P45880 | VDAC2 | S252 | ochoa | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P46013 | MKI67 | S1689 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | S544 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47914 | RPL29 | S31 | ochoa | Large ribosomal subunit protein eL29 (60S ribosomal protein L29) (Cell surface heparin-binding protein HIP) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P49790 | NUP153 | S386 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49796 | RGS3 | S946 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P50993 | ATP1A2 | S215 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P51116 | FXR2 | S637 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51805 | PLXNA3 | S1610 | ochoa | Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) | Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
| P54296 | MYOM2 | S62 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P57059 | SIK1 | S438 | ochoa | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| P57679 | EVC | S138 | ochoa | EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250|UniProtKB:P57680}. |
| P78524 | DENND2B | S525 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78559 | MAP1A | S322 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82912 | MRPS11 | S72 | ochoa | Small ribosomal subunit protein uS11m (28S ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2) | None |
| P98179 | RBM3 | S71 | ochoa | RNA-binding protein 3 (RNA-binding motif protein 3) (RNPL) | Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). {ECO:0000250}. |
| Q04637 | EIF4G1 | S1145 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q07157 | TJP1 | S337 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12802 | AKAP13 | S1507 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12802 | AKAP13 | S1900 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12802 | AKAP13 | S1932 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12815 | TROAP | S404 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12912 | IRAG2 | S378 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q12955 | ANK3 | S1462 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13322 | GRB10 | S431 | ochoa | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13370 | PDE3B | S299 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13393 | PLD1 | S508 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13439 | GOLGA4 | S74 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q13472 | TOP3A | S771 | ochoa | DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614). {ECO:0000269|PubMed:20445207, ECO:0000269|PubMed:29290614, ECO:0000269|PubMed:30057030, ECO:0000269|PubMed:8622991}. |
| Q13615 | MTMR3 | S652 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q13905 | RAPGEF1 | S314 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14126 | DSG2 | S680 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14161 | GIT2 | S361 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14194 | CRMP1 | S540 | ochoa | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
| Q14573 | ITPR3 | S1847 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14653 | IRF3 | S386 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14789 | GOLGB1 | S653 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14872 | MTF1 | S305 | ochoa|psp | Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) | Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). {ECO:0000250|UniProtKB:Q07243, ECO:0000269|PubMed:8065932}. |
| Q15036 | SNX17 | S440 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15075 | EEA1 | S359 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15139 | PRKD1 | S208 | ochoa|psp | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15276 | RABEP1 | S410 | ochoa | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
| Q15345 | LRRC41 | S330 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Q15596 | NCOA2 | S671 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15633 | TARBP2 | S286 | psp | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250|UniProtKB:P97473, ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:11438532, PubMed:12475984, PubMed:2011739). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269|PubMed:11438532, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:2011739, ECO:0000269|PubMed:30626973}. |
| Q15642 | TRIP10 | S299 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q16555 | DPYSL2 | S428 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q16555 | DPYSL2 | S540 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q2NKX8 | ERCC6L | S971 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2PPJ7 | RALGAPA2 | S376 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q3V6T2 | CCDC88A | S1590 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q5JSL3 | DOCK11 | S1240 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5S007 | LRRK2 | S976 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5SNT2 | TMEM201 | S444 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q5SNT2 | TMEM201 | S480 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q5SR56 | MFSD14B | S468 | ochoa | Hippocampus abundant transcript-like protein 1 (Major facilitator superfamily domain-containing 14B) | None |
| Q5SW79 | CEP170 | S1219 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T5Y3 | CAMSAP1 | S503 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TBA9 | FRY | S2490 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5TGY3 | AHDC1 | S172 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5THJ4 | VPS13D | S2864 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5U651 | RASIP1 | S331 | ochoa | Ras-interacting protein 1 (Rain) | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Q5VY43 | PEAR1 | S933 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q5VZF2 | MBNL2 | S56 | ochoa | Muscleblind-like protein 2 (Muscleblind-like protein 1) (Muscleblind-like protein-like) (Muscleblind-like protein-like 39) | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity). Regulates NCOR2 alternative splicing (By similarity). Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). {ECO:0000250|UniProtKB:F2Z3T4, ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16273094, ECO:0000269|PubMed:16946708}. |
| Q658Y4 | FAM91A1 | S674 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6GYQ0 | RALGAPA1 | S864 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6N021 | TET2 | S102 | ochoa | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}. |
| Q6N022 | TENM4 | S199 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6NY19 | KANK3 | S293 | ochoa | KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
| Q6P0Q8 | MAST2 | S151 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P4F7 | ARHGAP11A | S469 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6SJ93 | FAM111B | S352 | ochoa | Serine protease FAM111B (EC 3.4.21.-) (Cancer-associated nucleoprotein) | Serine protease. {ECO:0000250|UniProtKB:Q96PZ2}. |
| Q6WKZ4 | RAB11FIP1 | S438 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZRV2 | FAM83H | S813 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZSZ5 | ARHGEF18 | S67 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q6ZUT9 | DENND5B | S1079 | ochoa | DENN domain-containing protein 5B (Rab6IP1-like protein) | Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q7L5D6 | GET4 | S304 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q7Z402 | TMC7 | S89 | ochoa | Transmembrane channel-like protein 7 | Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}. |
| Q7Z591 | AKNA | S889 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5J4 | RAI1 | S574 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z7L1 | SLFN11 | S131 | ochoa | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86SQ0 | PHLDB2 | S163 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86T90 | KIAA1328 | S68 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86VF7 | NRAP | S1487 | ochoa | Nebulin-related-anchoring protein (N-RAP) | May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}. |
| Q86VY9 | TMEM200A | S326 | ochoa | Transmembrane protein 200A | None |
| Q86VZ1 | P2RY8 | S335 | ochoa | S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8) | G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed:25274307, PubMed:30842656, PubMed:34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed:25274307, PubMed:30842656, PubMed:34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed:30842656, PubMed:34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed:25274307). {ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:30842656, ECO:0000269|PubMed:34088745}. |
| Q86WB0 | ZC3HC1 | S87 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86X27 | RALGPS2 | S422 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q8IX03 | WWC1 | S978 | psp | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IZH2 | XRN1 | S1653 | ochoa | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. |
| Q8N137 | CNTROB | S41 | psp | Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}. |
| Q8N1G2 | CMTR1 | S49 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N1I0 | DOCK4 | S1769 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N392 | ARHGAP18 | S69 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8N6R0 | METTL13 | S269 | ochoa | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (PubMed:30143613, PubMed:30612740). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (PubMed:30143613). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (PubMed:30143613, PubMed:30612740). Has no activity towards core histones H2A, H2B, H3 and H4 (PubMed:30612740). {ECO:0000269|PubMed:30143613, ECO:0000269|PubMed:30612740}. |
| Q8N8S7 | ENAH | S531 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8NDX1 | PSD4 | S491 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NF91 | SYNE1 | S8258 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFP9 | NBEA | S1717 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8TBC3 | SHKBP1 | S640 | ochoa | SH3KBP1-binding protein 1 (SETA-binding protein 1) | Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}. |
| Q8TDM6 | DLG5 | S932 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TE68 | EPS8L1 | S583 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TF72 | SHROOM3 | S819 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WWI1 | LMO7 | S249 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXH0 | SYNE2 | Y4111 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92609 | TBC1D5 | S544 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92823 | NRCAM | S1254 | ochoa | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}. |
| Q96BY6 | DOCK10 | S1292 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96EP0 | RNF31 | S383 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
| Q96GY0 | ZC2HC1A | S279 | ochoa | Zinc finger C2HC domain-containing protein 1A | None |
| Q96JH8 | RADIL | S219 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96N46 | TTC14 | S583 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96N67 | DOCK7 | S414 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96PV4 | PNMA5 | S128 | ochoa | Paraneoplastic antigen-like protein 5 (Tumor antigen BJ-HCC-25) | None |
| Q96RU3 | FNBP1 | S299 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q99704 | DOK1 | S313 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q9BPU6 | DPYSL5 | S534 | ochoa | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | Involved in the negative regulation of dendrite outgrowth. {ECO:0000269|PubMed:33894126}. |
| Q9BR39 | JPH2 | S165 | ochoa|psp | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BSJ8 | ESYT1 | S860 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BSQ5 | CCM2 | S181 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BYW2 | SETD2 | S803 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C0B5 | ZDHHC5 | S299 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0K1 | SLC39A8 | S278 | ochoa | Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) | Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:26637978, PubMed:29337306, PubMed:29453449). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). May also transport iron and cobalt through membranes (PubMed:22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). With manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385). {ECO:0000250|UniProtKB:Q91W10, ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:19401385, ECO:0000269|PubMed:22898811, ECO:0000269|PubMed:23403290, ECO:0000269|PubMed:26637978, ECO:0000269|PubMed:27166256, ECO:0000269|PubMed:27466201, ECO:0000269|PubMed:28056086, ECO:0000269|PubMed:28481222, ECO:0000269|PubMed:29337306, ECO:0000269|PubMed:29453449, ECO:0000269|PubMed:29927450, ECO:0000269|PubMed:31699897}. |
| Q9H013 | ADAM19 | S756 | ochoa | Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM) | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}. |
| Q9H1A4 | ANAPC1 | S336 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H201 | EPN3 | S506 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H4A3 | WNK1 | S170 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H4G0 | EPB41L1 | S430 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H5N1 | RABEP2 | S189 | ochoa | Rab GTPase-binding effector protein 2 (Rabaptin-5beta) | Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}. |
| Q9HAW4 | CLSPN | S833 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HCD5 | NCOA5 | S381 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCS5 | EPB41L4A | S652 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NQG7 | HPS4 | S269 | ochoa | BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog) | Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). {ECO:0000269|PubMed:23084991}. |
| Q9NQW6 | ANLN | S661 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR56 | MBNL1 | S56 | ochoa | Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). Regulates NCOR2 alternative splicing (By similarity). {ECO:0000250|UniProtKB:A0A8I6B1J2, ECO:0000269|PubMed:10970838, ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:37548402}. |
| Q9NV58 | RNF19A | S69 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9NWQ8 | PAG1 | S333 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NZB2 | FAM120A | S1048 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZT2 | OGFR | S423 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P1Y5 | CAMSAP3 | S1051 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P273 | TENM3 | S202 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P2G1 | ANKIB1 | S782 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9UGP4 | LIMD1 | S243 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UIW2 | PLXNA1 | S1635 | ochoa | Plexin-A1 (Semaphorin receptor NOV) | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. {ECO:0000250|UniProtKB:P70206}. |
| Q9UKA4 | AKAP11 | S1526 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKK3 | PARP4 | S1338 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULH0 | KIDINS220 | S885 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULH0 | KIDINS220 | S1362 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULJ3 | ZBTB21 | S219 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULM3 | YEATS2 | S403 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UQ26 | RIMS2 | S403 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9Y277 | VDAC3 | S241 | ochoa | Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity). {ECO:0000250|UniProtKB:Q60931, ECO:0000269|PubMed:31935282}. |
| Q9Y2J2 | EPB41L3 | S443 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2K1 | ZBTB1 | S179 | ochoa | Zinc finger and BTB domain-containing protein 1 | Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}. |
| Q9Y4F1 | FARP1 | S473 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4G8 | RAPGEF2 | S1316 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y4X5 | ARIH1 | S517 | ochoa | E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1) | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:23707686, PubMed:24076655, PubMed:27565346). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916). In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197). {ECO:0000269|PubMed:14623119, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:17289916, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29689197}. |
| Q9Y5P4 | CERT1 | S126 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y6Q9 | NCOA3 | S1033 | ochoa|psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y6R9 | CCDC61 | S469 | ochoa | Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}. |
| Q9Y6X4 | FAM169A | S361 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| P00441 | SOD1 | S106 | Sugiyama | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| O94804 | STK10 | S824 | Sugiyama | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| P63151 | PPP2R2A | S412 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| Q66LE6 | PPP2R2D | S418 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity). {ECO:0000250|UniProtKB:Q7ZX64, ECO:0000250|UniProtKB:Q925E7}. |
| Q9UBR2 | CTSZ | S195 | Sugiyama | Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) | Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000269|PubMed:10504234}. |
| P05129 | PRKCG | S148 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| Q96T88 | UHRF1 | S675 | SIGNOR | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q00610 | CLTC | S1466 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q5JSH3 | WDR44 | S667 | Sugiyama | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q7Z7E8 | UBE2Q1 | S404 | Sugiyama | Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) | Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000269|PubMed:22496338}. |
| P00966 | ASS1 | S92 | Sugiyama | Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}. |
| Q14524 | SCN5A | S20 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.000007 | 5.148 |
| R-HSA-422475 | Axon guidance | 0.000070 | 4.152 |
| R-HSA-9675108 | Nervous system development | 0.000168 | 3.776 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.000213 | 3.672 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.000426 | 3.371 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.001054 | 2.977 |
| R-HSA-162582 | Signal Transduction | 0.000991 | 3.004 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.001365 | 2.865 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.002064 | 2.685 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.002492 | 2.603 |
| R-HSA-5578775 | Ion homeostasis | 0.002389 | 2.622 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.002271 | 2.644 |
| R-HSA-373760 | L1CAM interactions | 0.002827 | 2.549 |
| R-HSA-112043 | PLC beta mediated events | 0.003287 | 2.483 |
| R-HSA-111933 | Calmodulin induced events | 0.003525 | 2.453 |
| R-HSA-111997 | CaM pathway | 0.003525 | 2.453 |
| R-HSA-373755 | Semaphorin interactions | 0.003707 | 2.431 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.003931 | 2.406 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.004527 | 2.344 |
| R-HSA-112040 | G-protein mediated events | 0.004660 | 2.332 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.006080 | 2.216 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005979 | 2.223 |
| R-HSA-111996 | Ca-dependent events | 0.005968 | 2.224 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.007066 | 2.151 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.007026 | 2.153 |
| R-HSA-199991 | Membrane Trafficking | 0.007704 | 2.113 |
| R-HSA-75153 | Apoptotic execution phase | 0.007773 | 2.109 |
| R-HSA-437239 | Recycling pathway of L1 | 0.008274 | 2.082 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.009169 | 2.038 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.010993 | 1.959 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.010993 | 1.959 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.010204 | 1.991 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.010993 | 1.959 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.010993 | 1.959 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.011109 | 1.954 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.011149 | 1.953 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.013053 | 1.884 |
| R-HSA-418597 | G alpha (z) signalling events | 0.013057 | 1.884 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.014121 | 1.850 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.015071 | 1.822 |
| R-HSA-5576891 | Cardiac conduction | 0.019509 | 1.710 |
| R-HSA-5205647 | Mitophagy | 0.021303 | 1.672 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.022205 | 1.654 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.024078 | 1.618 |
| R-HSA-8853659 | RET signaling | 0.024078 | 1.618 |
| R-HSA-111885 | Opioid Signalling | 0.025196 | 1.599 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.033442 | 1.476 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.036533 | 1.437 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.031828 | 1.497 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.030460 | 1.516 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.033516 | 1.475 |
| R-HSA-169893 | Prolonged ERK activation events | 0.033442 | 1.476 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.033442 | 1.476 |
| R-HSA-1483148 | Synthesis of PG | 0.036533 | 1.437 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.030460 | 1.516 |
| R-HSA-4086400 | PCP/CE pathway | 0.035372 | 1.451 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.036533 | 1.437 |
| R-HSA-983712 | Ion channel transport | 0.030483 | 1.516 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.037646 | 1.424 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.039729 | 1.401 |
| R-HSA-2028269 | Signaling by Hippo | 0.039729 | 1.401 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.043028 | 1.366 |
| R-HSA-163615 | PKA activation | 0.043028 | 1.366 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.043028 | 1.366 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.050481 | 1.297 |
| R-HSA-8941237 | Invadopodia formation | 0.068646 | 1.163 |
| R-HSA-5660489 | MTF1 activates gene expression | 0.081801 | 1.087 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.081801 | 1.087 |
| R-HSA-447038 | NrCAM interactions | 0.094772 | 1.023 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.094772 | 1.023 |
| R-HSA-165160 | PDE3B signalling | 0.107560 | 0.968 |
| R-HSA-109703 | PKB-mediated events | 0.107560 | 0.968 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.132599 | 0.877 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.132599 | 0.877 |
| R-HSA-196025 | Formation of annular gap junctions | 0.144855 | 0.839 |
| R-HSA-170984 | ARMS-mediated activation | 0.156938 | 0.804 |
| R-HSA-190873 | Gap junction degradation | 0.156938 | 0.804 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.156938 | 0.804 |
| R-HSA-4839744 | Signaling by APC mutants | 0.180598 | 0.743 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.180598 | 0.743 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.180598 | 0.743 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.180598 | 0.743 |
| R-HSA-429947 | Deadenylation of mRNA | 0.068682 | 1.163 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.192178 | 0.716 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.192178 | 0.716 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.203596 | 0.691 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.203596 | 0.691 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.203596 | 0.691 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.203596 | 0.691 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.203596 | 0.691 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.203596 | 0.691 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.214853 | 0.668 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.225951 | 0.646 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.225951 | 0.646 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.236893 | 0.625 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.236893 | 0.625 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.236893 | 0.625 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.236893 | 0.625 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.236893 | 0.625 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.236893 | 0.625 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.247682 | 0.606 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.247682 | 0.606 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.247682 | 0.606 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.289337 | 0.539 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.289337 | 0.539 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.154542 | 0.811 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.299387 | 0.524 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.299387 | 0.524 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.299387 | 0.524 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.299387 | 0.524 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.309296 | 0.510 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.179590 | 0.746 |
| R-HSA-72649 | Translation initiation complex formation | 0.220744 | 0.656 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.356784 | 0.448 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.231164 | 0.636 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.392422 | 0.406 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.401020 | 0.397 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.409497 | 0.388 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.409497 | 0.388 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.426094 | 0.370 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.426094 | 0.370 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.244205 | 0.612 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.259353 | 0.586 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.259353 | 0.586 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.421107 | 0.376 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.179590 | 0.746 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.179590 | 0.746 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.093683 | 1.028 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.154542 | 0.811 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.241615 | 0.617 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.179590 | 0.746 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.184673 | 0.734 |
| R-HSA-191650 | Regulation of gap junction activity | 0.081801 | 1.087 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.374856 | 0.426 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.057269 | 1.242 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.381473 | 0.419 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.094772 | 1.023 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.120168 | 0.920 |
| R-HSA-5673000 | RAF activation | 0.116182 | 0.935 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.268805 | 0.571 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.426094 | 0.370 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.426094 | 0.370 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.244205 | 0.612 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.258318 | 0.588 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.282292 | 0.549 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.365884 | 0.437 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.282292 | 0.549 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.120168 | 0.920 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.168852 | 0.772 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.374856 | 0.426 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.197809 | 0.704 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.417854 | 0.379 |
| R-HSA-445144 | Signal transduction by L1 | 0.299387 | 0.524 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.081801 | 1.087 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.132599 | 0.877 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.168852 | 0.772 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.192178 | 0.716 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.192178 | 0.716 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.203596 | 0.691 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.203596 | 0.691 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.258318 | 0.588 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.071445 | 1.146 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.279144 | 0.554 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.279144 | 0.554 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.252086 | 0.598 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.383701 | 0.416 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.392422 | 0.406 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.361228 | 0.442 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.347554 | 0.459 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.416711 | 0.380 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.144855 | 0.839 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.299387 | 0.524 |
| R-HSA-5334118 | DNA methylation | 0.392422 | 0.406 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.401020 | 0.397 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.060926 | 1.215 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.278296 | 0.555 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.356784 | 0.448 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.279144 | 0.554 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.409497 | 0.388 |
| R-HSA-525793 | Myogenesis | 0.365884 | 0.437 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.178411 | 0.749 |
| R-HSA-74713 | IRS activation | 0.094772 | 1.023 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.107560 | 0.968 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.053498 | 1.272 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.168852 | 0.772 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.180598 | 0.743 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.068682 | 1.163 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.225951 | 0.646 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.258318 | 0.588 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.258318 | 0.588 |
| R-HSA-8875878 | MET promotes cell motility | 0.135051 | 0.870 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.309296 | 0.510 |
| R-HSA-420029 | Tight junction interactions | 0.356784 | 0.448 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.401020 | 0.397 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.392422 | 0.406 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.066558 | 1.177 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.309264 | 0.510 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.231164 | 0.636 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.194899 | 0.710 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.053498 | 1.272 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.258318 | 0.588 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.268805 | 0.571 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.319065 | 0.496 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.374856 | 0.426 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.374856 | 0.426 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.164164 | 0.785 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.426094 | 0.370 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.347554 | 0.459 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.411316 | 0.386 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.192178 | 0.716 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.258318 | 0.588 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.289337 | 0.539 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.144855 | 0.839 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.156938 | 0.804 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.060926 | 1.215 |
| R-HSA-425381 | Bicarbonate transporters | 0.180598 | 0.743 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.076742 | 1.115 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.236893 | 0.625 |
| R-HSA-187687 | Signalling to ERKs | 0.120833 | 0.918 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.278454 | 0.555 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.422858 | 0.374 |
| R-HSA-9909396 | Circadian clock | 0.061721 | 1.210 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.401020 | 0.397 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.156938 | 0.804 |
| R-HSA-5635838 | Activation of SMO | 0.247682 | 0.606 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.258318 | 0.588 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.073948 | 1.131 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.289337 | 0.539 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.426094 | 0.370 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.132873 | 0.877 |
| R-HSA-9663891 | Selective autophagy | 0.161103 | 0.793 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.295429 | 0.530 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.055050 | 1.259 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.094772 | 1.023 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.268805 | 0.571 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.139870 | 0.854 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.273055 | 0.564 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.417854 | 0.379 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.106840 | 0.971 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.150980 | 0.821 |
| R-HSA-1500620 | Meiosis | 0.147653 | 0.831 |
| R-HSA-68886 | M Phase | 0.350029 | 0.456 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.210743 | 0.676 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.262569 | 0.581 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.178411 | 0.749 |
| R-HSA-913531 | Interferon Signaling | 0.219647 | 0.658 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.235007 | 0.629 |
| R-HSA-73887 | Death Receptor Signaling | 0.230314 | 0.638 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.156938 | 0.804 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.236893 | 0.625 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.130270 | 0.885 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.268805 | 0.571 |
| R-HSA-1221632 | Meiotic synapsis | 0.215549 | 0.666 |
| R-HSA-77387 | Insulin receptor recycling | 0.383701 | 0.416 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.409497 | 0.388 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.409497 | 0.388 |
| R-HSA-195721 | Signaling by WNT | 0.300051 | 0.523 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.240441 | 0.619 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.240441 | 0.619 |
| R-HSA-170968 | Frs2-mediated activation | 0.214853 | 0.668 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.409497 | 0.388 |
| R-HSA-9659379 | Sensory processing of sound | 0.351013 | 0.455 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.330424 | 0.481 |
| R-HSA-8848021 | Signaling by PTK6 | 0.081685 | 1.088 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.081685 | 1.088 |
| R-HSA-8964038 | LDL clearance | 0.328696 | 0.483 |
| R-HSA-9833110 | RSV-host interactions | 0.229210 | 0.640 |
| R-HSA-68875 | Mitotic Prophase | 0.125471 | 0.901 |
| R-HSA-447043 | Neurofascin interactions | 0.120168 | 0.920 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.156938 | 0.804 |
| R-HSA-74749 | Signal attenuation | 0.168852 | 0.772 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.268805 | 0.571 |
| R-HSA-392517 | Rap1 signalling | 0.289337 | 0.539 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.289337 | 0.539 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.231164 | 0.636 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.365884 | 0.437 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.118252 | 0.927 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.294001 | 0.532 |
| R-HSA-1266738 | Developmental Biology | 0.371382 | 0.430 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.068982 | 1.161 |
| R-HSA-1632852 | Macroautophagy | 0.189203 | 0.723 |
| R-HSA-5660526 | Response to metal ions | 0.258318 | 0.588 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.225951 | 0.646 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.279144 | 0.554 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.231164 | 0.636 |
| R-HSA-70635 | Urea cycle | 0.365884 | 0.437 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.392422 | 0.406 |
| R-HSA-112316 | Neuronal System | 0.092020 | 1.036 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.118647 | 0.926 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.426094 | 0.370 |
| R-HSA-9607240 | FLT3 Signaling | 0.149618 | 0.825 |
| R-HSA-1474165 | Reproduction | 0.058945 | 1.230 |
| R-HSA-397014 | Muscle contraction | 0.115546 | 0.937 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.203596 | 0.691 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.214853 | 0.668 |
| R-HSA-416700 | Other semaphorin interactions | 0.236893 | 0.625 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.401020 | 0.397 |
| R-HSA-4086398 | Ca2+ pathway | 0.320061 | 0.495 |
| R-HSA-9612973 | Autophagy | 0.236364 | 0.626 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.332455 | 0.478 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.168852 | 0.772 |
| R-HSA-210991 | Basigin interactions | 0.309296 | 0.510 |
| R-HSA-163685 | Integration of energy metabolism | 0.371016 | 0.431 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.144819 | 0.839 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.093683 | 1.028 |
| R-HSA-180292 | GAB1 signalosome | 0.279144 | 0.554 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.115546 | 0.937 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.426094 | 0.370 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.247682 | 0.606 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.319065 | 0.496 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.374856 | 0.426 |
| R-HSA-9707616 | Heme signaling | 0.262569 | 0.581 |
| R-HSA-6806834 | Signaling by MET | 0.356127 | 0.448 |
| R-HSA-435354 | Zinc transporters | 0.225951 | 0.646 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.236893 | 0.625 |
| R-HSA-373753 | Nephrin family interactions | 0.299387 | 0.524 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.164481 | 0.784 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.278454 | 0.555 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.120998 | 0.917 |
| R-HSA-9833482 | PKR-mediated signaling | 0.356127 | 0.448 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.289337 | 0.539 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.267812 | 0.572 |
| R-HSA-194138 | Signaling by VEGF | 0.320857 | 0.494 |
| R-HSA-165159 | MTOR signalling | 0.159497 | 0.797 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.242515 | 0.615 |
| R-HSA-166520 | Signaling by NTRKs | 0.420475 | 0.376 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.289337 | 0.539 |
| R-HSA-3000170 | Syndecan interactions | 0.338192 | 0.471 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.345884 | 0.461 |
| R-HSA-186763 | Downstream signal transduction | 0.409497 | 0.388 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.410276 | 0.387 |
| R-HSA-373752 | Netrin-1 signaling | 0.169492 | 0.771 |
| R-HSA-1483166 | Synthesis of PA | 0.236386 | 0.626 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.320061 | 0.495 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.351013 | 0.455 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.135051 | 0.870 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.225950 | 0.646 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.064765 | 1.189 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.292264 | 0.534 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.319065 | 0.496 |
| R-HSA-182971 | EGFR downregulation | 0.409497 | 0.388 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.340743 | 0.468 |
| R-HSA-177929 | Signaling by EGFR | 0.231164 | 0.636 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.207075 | 0.684 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.374854 | 0.426 |
| R-HSA-5688426 | Deubiquitination | 0.353579 | 0.452 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.392422 | 0.406 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.426094 | 0.370 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.425972 | 0.371 |
| R-HSA-109581 | Apoptosis | 0.254735 | 0.594 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.278296 | 0.555 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.218334 | 0.661 |
| R-HSA-5357801 | Programmed Cell Death | 0.397727 | 0.400 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.335589 | 0.474 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.396479 | 0.402 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.429079 | 0.367 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.434218 | 0.362 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.434218 | 0.362 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.434218 | 0.362 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.434218 | 0.362 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.434218 | 0.362 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.434218 | 0.362 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.434218 | 0.362 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.434218 | 0.362 |
| R-HSA-9679506 | SARS-CoV Infections | 0.434606 | 0.362 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.442227 | 0.354 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.442227 | 0.354 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.442227 | 0.354 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.442227 | 0.354 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.442883 | 0.354 |
| R-HSA-1989781 | PPARA activates gene expression | 0.446586 | 0.350 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.448449 | 0.348 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.449969 | 0.347 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.449969 | 0.347 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.450123 | 0.347 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.450123 | 0.347 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.450123 | 0.347 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.450123 | 0.347 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.453962 | 0.343 |
| R-HSA-382551 | Transport of small molecules | 0.456802 | 0.340 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.457908 | 0.339 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.457908 | 0.339 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.457908 | 0.339 |
| R-HSA-422356 | Regulation of insulin secretion | 0.459410 | 0.338 |
| R-HSA-877300 | Interferon gamma signaling | 0.461298 | 0.336 |
| R-HSA-1640170 | Cell Cycle | 0.463831 | 0.334 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.463839 | 0.334 |
| R-HSA-3214847 | HATs acetylate histones | 0.464095 | 0.333 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.465583 | 0.332 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.465583 | 0.332 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.465583 | 0.332 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.465583 | 0.332 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.467651 | 0.330 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.468756 | 0.329 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.473150 | 0.325 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.473150 | 0.325 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.473150 | 0.325 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.473150 | 0.325 |
| R-HSA-109582 | Hemostasis | 0.475391 | 0.323 |
| R-HSA-1483255 | PI Metabolism | 0.478005 | 0.321 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.480610 | 0.318 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.480610 | 0.318 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.480610 | 0.318 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.487157 | 0.312 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.487965 | 0.312 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.487965 | 0.312 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.487965 | 0.312 |
| R-HSA-202433 | Generation of second messenger molecules | 0.487965 | 0.312 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.495216 | 0.305 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.495216 | 0.305 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.495216 | 0.305 |
| R-HSA-9694548 | Maturation of spike protein | 0.495216 | 0.305 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.495216 | 0.305 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.495216 | 0.305 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.502365 | 0.299 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.502365 | 0.299 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.502365 | 0.299 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.502365 | 0.299 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.502365 | 0.299 |
| R-HSA-211000 | Gene Silencing by RNA | 0.505157 | 0.297 |
| R-HSA-157118 | Signaling by NOTCH | 0.506499 | 0.295 |
| R-HSA-991365 | Activation of GABAB receptors | 0.509414 | 0.293 |
| R-HSA-977444 | GABA B receptor activation | 0.509414 | 0.293 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.509414 | 0.293 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.509414 | 0.293 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.509593 | 0.293 |
| R-HSA-8854214 | TBC/RABGAPs | 0.516362 | 0.287 |
| R-HSA-202403 | TCR signaling | 0.518387 | 0.285 |
| R-HSA-190828 | Gap junction trafficking | 0.523213 | 0.281 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.523213 | 0.281 |
| R-HSA-69236 | G1 Phase | 0.523213 | 0.281 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.523213 | 0.281 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.527077 | 0.278 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.529968 | 0.276 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.529968 | 0.276 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.529968 | 0.276 |
| R-HSA-168255 | Influenza Infection | 0.535490 | 0.271 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.535660 | 0.271 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.535660 | 0.271 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.536627 | 0.270 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.536627 | 0.270 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.536627 | 0.270 |
| R-HSA-9675135 | Diseases of DNA repair | 0.536627 | 0.270 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.536627 | 0.270 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.539505 | 0.268 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.543192 | 0.265 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.543192 | 0.265 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.548333 | 0.261 |
| R-HSA-9634597 | GPER1 signaling | 0.549664 | 0.260 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.549664 | 0.260 |
| R-HSA-425410 | Metal ion SLC transporters | 0.549664 | 0.260 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.556045 | 0.255 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.559020 | 0.253 |
| R-HSA-5693538 | Homology Directed Repair | 0.560764 | 0.251 |
| R-HSA-109704 | PI3K Cascade | 0.562336 | 0.250 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.568539 | 0.245 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.568539 | 0.245 |
| R-HSA-912446 | Meiotic recombination | 0.568539 | 0.245 |
| R-HSA-2514856 | The phototransduction cascade | 0.568539 | 0.245 |
| R-HSA-418594 | G alpha (i) signalling events | 0.570443 | 0.244 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.574653 | 0.241 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.574653 | 0.241 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.580682 | 0.236 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.580682 | 0.236 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.586625 | 0.232 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.586873 | 0.231 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.592485 | 0.227 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.592711 | 0.227 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.592711 | 0.227 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.592711 | 0.227 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.596581 | 0.224 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.598262 | 0.223 |
| R-HSA-75893 | TNF signaling | 0.598262 | 0.223 |
| R-HSA-69481 | G2/M Checkpoints | 0.600423 | 0.222 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.603587 | 0.219 |
| R-HSA-112399 | IRS-mediated signalling | 0.603957 | 0.219 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.604222 | 0.219 |
| R-HSA-428157 | Sphingolipid metabolism | 0.606662 | 0.217 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.609721 | 0.215 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.615108 | 0.211 |
| R-HSA-191859 | snRNP Assembly | 0.615108 | 0.211 |
| R-HSA-9843745 | Adipogenesis | 0.619223 | 0.208 |
| R-HSA-977443 | GABA receptor activation | 0.620565 | 0.207 |
| R-HSA-983189 | Kinesins | 0.620565 | 0.207 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.625946 | 0.203 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.625946 | 0.203 |
| R-HSA-211976 | Endogenous sterols | 0.625946 | 0.203 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.625946 | 0.203 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.631250 | 0.200 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.631250 | 0.200 |
| R-HSA-1268020 | Mitochondrial protein import | 0.631250 | 0.200 |
| R-HSA-186797 | Signaling by PDGF | 0.631250 | 0.200 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.636480 | 0.196 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.640879 | 0.193 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.641635 | 0.193 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.646718 | 0.189 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.646718 | 0.189 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.647880 | 0.189 |
| R-HSA-68882 | Mitotic Anaphase | 0.653690 | 0.185 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.656493 | 0.183 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.656670 | 0.183 |
| R-HSA-196807 | Nicotinate metabolism | 0.656670 | 0.183 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.656670 | 0.183 |
| R-HSA-1483257 | Phospholipid metabolism | 0.656734 | 0.183 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.664911 | 0.177 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.666342 | 0.176 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.671076 | 0.173 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.671076 | 0.173 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.671076 | 0.173 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.671076 | 0.173 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.675743 | 0.170 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.675743 | 0.170 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.675743 | 0.170 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.680345 | 0.167 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.682623 | 0.166 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.684881 | 0.164 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.684881 | 0.164 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.684881 | 0.164 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.686246 | 0.164 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.689353 | 0.162 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.689353 | 0.162 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.689353 | 0.162 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.692866 | 0.159 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.693893 | 0.159 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.696983 | 0.157 |
| R-HSA-388396 | GPCR downstream signalling | 0.697709 | 0.156 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.698108 | 0.156 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.700047 | 0.155 |
| R-HSA-9609507 | Protein localization | 0.700047 | 0.155 |
| R-HSA-69306 | DNA Replication | 0.700047 | 0.155 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.701650 | 0.154 |
| R-HSA-1500931 | Cell-Cell communication | 0.705323 | 0.152 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.706098 | 0.151 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.714889 | 0.146 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.714889 | 0.146 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.714985 | 0.146 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.718937 | 0.143 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.722927 | 0.141 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.722927 | 0.141 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.726862 | 0.139 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.732082 | 0.135 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.732085 | 0.135 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.734564 | 0.134 |
| R-HSA-4839726 | Chromatin organization | 0.737638 | 0.132 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.738334 | 0.132 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.738334 | 0.132 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.742050 | 0.130 |
| R-HSA-421270 | Cell-cell junction organization | 0.742169 | 0.129 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.745714 | 0.127 |
| R-HSA-70268 | Pyruvate metabolism | 0.745714 | 0.127 |
| R-HSA-156902 | Peptide chain elongation | 0.749326 | 0.125 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.750930 | 0.124 |
| R-HSA-418555 | G alpha (s) signalling events | 0.753527 | 0.123 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.753527 | 0.123 |
| R-HSA-1280218 | Adaptive Immune System | 0.755248 | 0.122 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.758652 | 0.120 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.758652 | 0.120 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.759859 | 0.119 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.759859 | 0.119 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.763271 | 0.117 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.763685 | 0.117 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.766635 | 0.115 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.766635 | 0.115 |
| R-HSA-391251 | Protein folding | 0.766635 | 0.115 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.769951 | 0.114 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.769951 | 0.114 |
| R-HSA-416476 | G alpha (q) signalling events | 0.770122 | 0.113 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.773220 | 0.112 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.776443 | 0.110 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.776443 | 0.110 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.779621 | 0.108 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.779621 | 0.108 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.779621 | 0.108 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.782753 | 0.106 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.782753 | 0.106 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.782753 | 0.106 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.785841 | 0.105 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.786253 | 0.104 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.788885 | 0.103 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.791887 | 0.101 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.794235 | 0.100 |
| R-HSA-70171 | Glycolysis | 0.794845 | 0.100 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.794845 | 0.100 |
| R-HSA-446728 | Cell junction organization | 0.797421 | 0.098 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.797762 | 0.098 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.800638 | 0.097 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.800638 | 0.097 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.800772 | 0.096 |
| R-HSA-9658195 | Leishmania infection | 0.802908 | 0.095 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.802908 | 0.095 |
| R-HSA-192823 | Viral mRNA Translation | 0.803473 | 0.095 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.803473 | 0.095 |
| R-HSA-372790 | Signaling by GPCR | 0.804979 | 0.094 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.806268 | 0.094 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.806268 | 0.094 |
| R-HSA-2262752 | Cellular responses to stress | 0.808745 | 0.092 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.809023 | 0.092 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.809023 | 0.092 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.809023 | 0.092 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.811260 | 0.091 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.811739 | 0.091 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.814417 | 0.089 |
| R-HSA-418346 | Platelet homeostasis | 0.814417 | 0.089 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.817056 | 0.088 |
| R-HSA-69239 | Synthesis of DNA | 0.817056 | 0.088 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.822224 | 0.085 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.822224 | 0.085 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.822224 | 0.085 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.824754 | 0.084 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.824754 | 0.084 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.824754 | 0.084 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.825119 | 0.083 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.832128 | 0.080 |
| R-HSA-9824446 | Viral Infection Pathways | 0.837205 | 0.077 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.839194 | 0.076 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.841483 | 0.075 |
| R-HSA-70326 | Glucose metabolism | 0.845963 | 0.073 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.845963 | 0.073 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.845963 | 0.073 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.848156 | 0.072 |
| R-HSA-418990 | Adherens junctions interactions | 0.853428 | 0.069 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.854550 | 0.068 |
| R-HSA-3371556 | Cellular response to heat stress | 0.854550 | 0.068 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.854550 | 0.068 |
| R-HSA-8951664 | Neddylation | 0.858249 | 0.066 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.858663 | 0.066 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.858663 | 0.066 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.860675 | 0.065 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.860675 | 0.065 |
| R-HSA-114608 | Platelet degranulation | 0.868445 | 0.061 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.873988 | 0.058 |
| R-HSA-72312 | rRNA processing | 0.874715 | 0.058 |
| R-HSA-1474244 | Extracellular matrix organization | 0.877409 | 0.057 |
| R-HSA-9717189 | Sensory perception of taste | 0.877553 | 0.057 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.879298 | 0.056 |
| R-HSA-8939211 | ESR-mediated signaling | 0.881603 | 0.055 |
| R-HSA-72766 | Translation | 0.884511 | 0.053 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.890838 | 0.050 |
| R-HSA-5368287 | Mitochondrial translation | 0.890838 | 0.050 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.892395 | 0.049 |
| R-HSA-9664407 | Parasite infection | 0.893929 | 0.049 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.893929 | 0.049 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.893929 | 0.049 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.895441 | 0.048 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.898402 | 0.047 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.904075 | 0.044 |
| R-HSA-2187338 | Visual phototransduction | 0.905444 | 0.043 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.906793 | 0.042 |
| R-HSA-69242 | S Phase | 0.906793 | 0.042 |
| R-HSA-6798695 | Neutrophil degranulation | 0.910364 | 0.041 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.912000 | 0.040 |
| R-HSA-9610379 | HCMV Late Events | 0.918103 | 0.037 |
| R-HSA-162587 | HIV Life Cycle | 0.918103 | 0.037 |
| R-HSA-9711097 | Cellular response to starvation | 0.919272 | 0.037 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.921560 | 0.035 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.921560 | 0.035 |
| R-HSA-8953854 | Metabolism of RNA | 0.923417 | 0.035 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.925945 | 0.033 |
| R-HSA-168256 | Immune System | 0.927519 | 0.033 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.929073 | 0.032 |
| R-HSA-5619102 | SLC transporter disorders | 0.929073 | 0.032 |
| R-HSA-72306 | tRNA processing | 0.933040 | 0.030 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.935869 | 0.029 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.935869 | 0.029 |
| R-HSA-2559583 | Cellular Senescence | 0.942017 | 0.026 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.944468 | 0.025 |
| R-HSA-69275 | G2/M Transition | 0.946817 | 0.024 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.948327 | 0.023 |
| R-HSA-68877 | Mitotic Prometaphase | 0.951919 | 0.021 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.952301 | 0.021 |
| R-HSA-9609690 | HCMV Early Events | 0.953953 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 0.957296 | 0.019 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.958373 | 0.018 |
| R-HSA-6805567 | Keratinization | 0.960707 | 0.017 |
| R-HSA-162906 | HIV Infection | 0.970981 | 0.013 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.972211 | 0.012 |
| R-HSA-73894 | DNA Repair | 0.972447 | 0.012 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.973444 | 0.012 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.974884 | 0.011 |
| R-HSA-5663205 | Infectious disease | 0.976531 | 0.010 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.978265 | 0.010 |
| R-HSA-9609646 | HCMV Infection | 0.979188 | 0.009 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.982756 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.982792 | 0.008 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.986123 | 0.006 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.986323 | 0.006 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.989154 | 0.005 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.992455 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.993892 | 0.003 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.994440 | 0.002 |
| R-HSA-1643685 | Disease | 0.994610 | 0.002 |
| R-HSA-449147 | Signaling by Interleukins | 0.995241 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.996004 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.996022 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.998571 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.998963 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999017 | 0.000 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.999104 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999618 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999667 | 0.000 |
| R-HSA-74160 | Gene expression (Transcription) | 0.999758 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999989 | 0.000 |
| R-HSA-212436 | Generic Transcription Pathway | 0.999994 | 0.000 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
IKKE |
0.790 | 0.376 | 1 | 0.402 |
COT |
0.790 | 0.111 | 2 | 0.905 |
TBK1 |
0.788 | 0.344 | 1 | 0.375 |
IKKB |
0.786 | 0.210 | -2 | 0.798 |
CK1G1 |
0.784 | 0.354 | -3 | 0.767 |
KIS |
0.780 | 0.037 | 1 | 0.127 |
MTOR |
0.780 | 0.119 | 1 | 0.239 |
GRK1 |
0.778 | 0.161 | -2 | 0.808 |
RAF1 |
0.777 | 0.276 | 1 | 0.317 |
DSTYK |
0.776 | 0.094 | 2 | 0.925 |
CK1E |
0.774 | 0.280 | -3 | 0.771 |
MST4 |
0.774 | 0.141 | 2 | 0.894 |
IKKA |
0.772 | 0.122 | -2 | 0.795 |
GCN2 |
0.772 | -0.022 | 2 | 0.850 |
CDC7 |
0.771 | -0.029 | 1 | 0.155 |
CLK3 |
0.771 | 0.025 | 1 | 0.143 |
CK1D |
0.769 | 0.295 | -3 | 0.757 |
MOS |
0.769 | 0.006 | 1 | 0.164 |
BCKDK |
0.769 | 0.168 | -1 | 0.768 |
PDHK1 |
0.767 | 0.196 | 1 | 0.317 |
PDHK4 |
0.767 | 0.105 | 1 | 0.267 |
ULK2 |
0.766 | -0.007 | 2 | 0.821 |
NDR2 |
0.766 | 0.009 | -3 | 0.538 |
PRPK |
0.766 | -0.005 | -1 | 0.826 |
PIM3 |
0.765 | -0.020 | -3 | 0.542 |
NEK6 |
0.765 | 0.007 | -2 | 0.871 |
CK1A2 |
0.765 | 0.289 | -3 | 0.752 |
NEK7 |
0.765 | 0.029 | -3 | 0.612 |
GRK6 |
0.764 | 0.099 | 1 | 0.187 |
NLK |
0.764 | 0.004 | 1 | 0.193 |
CAMK2G |
0.763 | 0.014 | 2 | 0.850 |
MLK1 |
0.763 | 0.059 | 2 | 0.858 |
DNAPK |
0.762 | 0.122 | 1 | 0.312 |
YSK4 |
0.762 | 0.222 | 1 | 0.305 |
BMPR2 |
0.761 | 0.041 | -2 | 0.905 |
SRPK1 |
0.761 | 0.005 | -3 | 0.474 |
GRK5 |
0.761 | 0.041 | -3 | 0.689 |
BMPR1B |
0.760 | 0.045 | 1 | 0.132 |
ATR |
0.759 | -0.044 | 1 | 0.174 |
NDR1 |
0.759 | -0.010 | -3 | 0.530 |
PKN3 |
0.759 | -0.017 | -3 | 0.527 |
ULK1 |
0.759 | -0.032 | -3 | 0.592 |
PKN2 |
0.758 | 0.026 | -3 | 0.547 |
PRKD1 |
0.758 | 0.008 | -3 | 0.485 |
GRK4 |
0.758 | 0.077 | -2 | 0.837 |
ERK5 |
0.758 | -0.056 | 1 | 0.160 |
TGFBR2 |
0.758 | 0.027 | -2 | 0.809 |
GRK7 |
0.757 | 0.072 | 1 | 0.158 |
CDK8 |
0.757 | -0.044 | 1 | 0.110 |
RSK2 |
0.756 | -0.010 | -3 | 0.464 |
CAMK2D |
0.756 | 0.039 | -3 | 0.518 |
NEK9 |
0.756 | 0.031 | 2 | 0.880 |
LATS2 |
0.756 | 0.013 | -5 | 0.794 |
CDK1 |
0.755 | -0.020 | 1 | 0.101 |
WNK1 |
0.755 | 0.020 | -2 | 0.867 |
SRPK3 |
0.755 | 0.027 | -3 | 0.483 |
CAMK1B |
0.755 | -0.053 | -3 | 0.561 |
CDK19 |
0.755 | -0.042 | 1 | 0.105 |
JNK2 |
0.755 | -0.005 | 1 | 0.133 |
TTBK2 |
0.754 | 0.055 | 2 | 0.730 |
PIM1 |
0.754 | -0.003 | -3 | 0.512 |
SRPK2 |
0.754 | 0.004 | -3 | 0.422 |
CDKL1 |
0.754 | -0.039 | -3 | 0.521 |
HUNK |
0.754 | -0.057 | 2 | 0.825 |
CHAK2 |
0.754 | -0.004 | -1 | 0.786 |
HIPK4 |
0.754 | -0.035 | 1 | 0.150 |
JNK3 |
0.754 | -0.013 | 1 | 0.124 |
NUAK2 |
0.754 | -0.031 | -3 | 0.535 |
DLK |
0.753 | 0.058 | 1 | 0.199 |
PKCD |
0.753 | 0.024 | 2 | 0.835 |
P38G |
0.753 | -0.021 | 1 | 0.090 |
RIPK3 |
0.753 | -0.035 | 3 | 0.650 |
FAM20C |
0.752 | 0.034 | 2 | 0.643 |
TGFBR1 |
0.752 | 0.022 | -2 | 0.842 |
NIK |
0.752 | -0.014 | -3 | 0.586 |
ATM |
0.752 | -0.035 | 1 | 0.159 |
CAMK2B |
0.752 | 0.034 | 2 | 0.834 |
PRKD2 |
0.752 | -0.004 | -3 | 0.434 |
MAPKAPK2 |
0.751 | -0.025 | -3 | 0.427 |
LATS1 |
0.751 | 0.072 | -3 | 0.539 |
PKACG |
0.750 | 0.015 | -2 | 0.712 |
P90RSK |
0.750 | -0.025 | -3 | 0.472 |
PLK1 |
0.750 | 0.026 | -2 | 0.841 |
MEKK3 |
0.749 | 0.168 | 1 | 0.239 |
DYRK2 |
0.749 | -0.040 | 1 | 0.120 |
CDK13 |
0.749 | -0.041 | 1 | 0.122 |
CDKL5 |
0.749 | -0.049 | -3 | 0.501 |
CDK5 |
0.749 | -0.026 | 1 | 0.115 |
ERK1 |
0.748 | -0.024 | 1 | 0.128 |
MARK4 |
0.748 | -0.025 | 4 | 0.847 |
CDK18 |
0.748 | -0.038 | 1 | 0.097 |
WNK3 |
0.748 | -0.007 | 1 | 0.256 |
MLK2 |
0.748 | -0.037 | 2 | 0.868 |
AMPKA1 |
0.748 | -0.041 | -3 | 0.537 |
SKMLCK |
0.748 | -0.050 | -2 | 0.838 |
PKR |
0.747 | 0.061 | 1 | 0.205 |
RSK3 |
0.747 | -0.031 | -3 | 0.456 |
P70S6KB |
0.747 | -0.018 | -3 | 0.495 |
MLK3 |
0.747 | -0.011 | 2 | 0.793 |
ANKRD3 |
0.747 | 0.030 | 1 | 0.227 |
MASTL |
0.747 | -0.061 | -2 | 0.838 |
HIPK2 |
0.747 | -0.029 | 1 | 0.098 |
ACVR2B |
0.747 | 0.015 | -2 | 0.823 |
MAPKAPK3 |
0.747 | -0.035 | -3 | 0.451 |
CDK17 |
0.747 | -0.043 | 1 | 0.086 |
ACVR2A |
0.747 | 0.023 | -2 | 0.810 |
ALK4 |
0.746 | 0.022 | -2 | 0.858 |
TLK2 |
0.746 | 0.071 | 1 | 0.230 |
NEK2 |
0.746 | 0.064 | 2 | 0.858 |
IRE1 |
0.746 | -0.043 | 1 | 0.167 |
BMPR1A |
0.745 | 0.027 | 1 | 0.123 |
P38B |
0.745 | -0.028 | 1 | 0.121 |
ICK |
0.745 | -0.035 | -3 | 0.537 |
PKCA |
0.744 | 0.042 | 2 | 0.778 |
RSK4 |
0.744 | 0.003 | -3 | 0.451 |
CLK2 |
0.744 | 0.009 | -3 | 0.466 |
MLK4 |
0.744 | 0.011 | 2 | 0.772 |
MST3 |
0.744 | 0.158 | 2 | 0.871 |
PKCG |
0.744 | 0.022 | 2 | 0.781 |
CAMLCK |
0.744 | -0.057 | -2 | 0.837 |
ALK2 |
0.743 | 0.016 | -2 | 0.841 |
CAMK2A |
0.743 | 0.006 | 2 | 0.854 |
P38D |
0.743 | -0.020 | 1 | 0.097 |
PLK3 |
0.743 | -0.010 | 2 | 0.795 |
AMPKA2 |
0.743 | -0.041 | -3 | 0.504 |
PKCB |
0.743 | -0.009 | 2 | 0.794 |
TLK1 |
0.743 | 0.111 | -2 | 0.853 |
AURC |
0.743 | 0.006 | -2 | 0.618 |
CDK12 |
0.743 | -0.043 | 1 | 0.121 |
MEK1 |
0.743 | 0.071 | 2 | 0.889 |
CDK7 |
0.743 | -0.065 | 1 | 0.121 |
NIM1 |
0.743 | -0.046 | 3 | 0.683 |
CK2A2 |
0.742 | 0.010 | 1 | 0.107 |
PHKG1 |
0.742 | -0.012 | -3 | 0.520 |
MSK2 |
0.742 | -0.035 | -3 | 0.473 |
GRK2 |
0.742 | 0.016 | -2 | 0.738 |
RIPK1 |
0.742 | -0.084 | 1 | 0.184 |
CK1A |
0.742 | 0.246 | -3 | 0.725 |
CDK3 |
0.742 | -0.034 | 1 | 0.088 |
MINK |
0.740 | 0.324 | 1 | 0.357 |
ZAK |
0.740 | 0.062 | 1 | 0.221 |
MEKK1 |
0.740 | 0.060 | 1 | 0.230 |
TSSK2 |
0.740 | -0.037 | -5 | 0.824 |
DAPK2 |
0.740 | -0.093 | -3 | 0.562 |
TAO3 |
0.740 | 0.127 | 1 | 0.251 |
HIPK1 |
0.739 | -0.033 | 1 | 0.125 |
MEKK2 |
0.739 | 0.116 | 2 | 0.853 |
P38A |
0.739 | -0.040 | 1 | 0.135 |
GCK |
0.739 | 0.296 | 1 | 0.349 |
IRE2 |
0.739 | -0.052 | 2 | 0.766 |
PKACB |
0.739 | -0.001 | -2 | 0.637 |
HPK1 |
0.739 | 0.328 | 1 | 0.389 |
TSSK1 |
0.739 | -0.030 | -3 | 0.537 |
MST2 |
0.738 | 0.228 | 1 | 0.313 |
CDK9 |
0.738 | -0.059 | 1 | 0.130 |
AURA |
0.738 | 0.039 | -2 | 0.591 |
ERK2 |
0.738 | -0.045 | 1 | 0.132 |
GRK3 |
0.738 | 0.051 | -2 | 0.689 |
MSK1 |
0.738 | -0.008 | -3 | 0.464 |
CDK16 |
0.738 | -0.036 | 1 | 0.090 |
PLK4 |
0.738 | 0.032 | 2 | 0.641 |
CHAK1 |
0.737 | -0.023 | 2 | 0.799 |
PKCH |
0.737 | -0.004 | 2 | 0.771 |
SMG1 |
0.737 | -0.064 | 1 | 0.177 |
CAMK4 |
0.737 | -0.084 | -3 | 0.525 |
SGK3 |
0.736 | 0.004 | -3 | 0.460 |
PAK1 |
0.736 | -0.038 | -2 | 0.754 |
KHS2 |
0.736 | 0.318 | 1 | 0.407 |
CDK10 |
0.736 | -0.021 | 1 | 0.113 |
CLK4 |
0.736 | -0.029 | -3 | 0.491 |
CK2A1 |
0.736 | 0.014 | 1 | 0.106 |
CDK2 |
0.736 | -0.061 | 1 | 0.121 |
DYRK4 |
0.736 | -0.041 | 1 | 0.101 |
KHS1 |
0.735 | 0.332 | 1 | 0.404 |
NUAK1 |
0.735 | -0.069 | -3 | 0.478 |
PHKG2 |
0.735 | 0.024 | -3 | 0.485 |
PAK3 |
0.735 | -0.047 | -2 | 0.760 |
QSK |
0.735 | -0.020 | 4 | 0.821 |
PRKD3 |
0.735 | -0.038 | -3 | 0.432 |
CLK1 |
0.734 | -0.028 | -3 | 0.446 |
MNK2 |
0.734 | -0.026 | -2 | 0.776 |
MNK1 |
0.734 | -0.023 | -2 | 0.786 |
AKT2 |
0.734 | -0.011 | -3 | 0.412 |
PERK |
0.734 | -0.005 | -2 | 0.846 |
PRKX |
0.734 | -0.005 | -3 | 0.401 |
MEK5 |
0.733 | 0.030 | 2 | 0.869 |
VRK2 |
0.733 | -0.105 | 1 | 0.184 |
PKCZ |
0.733 | -0.050 | 2 | 0.826 |
TNIK |
0.733 | 0.213 | 3 | 0.775 |
SIK |
0.733 | -0.039 | -3 | 0.467 |
QIK |
0.732 | -0.058 | -3 | 0.527 |
JNK1 |
0.732 | -0.031 | 1 | 0.114 |
AURB |
0.732 | 0.006 | -2 | 0.616 |
BRAF |
0.732 | 0.003 | -4 | 0.811 |
HGK |
0.732 | 0.191 | 3 | 0.776 |
CK1G3 |
0.732 | 0.293 | -3 | 0.697 |
BRSK1 |
0.732 | -0.054 | -3 | 0.479 |
CDK14 |
0.731 | -0.045 | 1 | 0.127 |
HRI |
0.731 | -0.036 | -2 | 0.854 |
PIM2 |
0.731 | -0.025 | -3 | 0.450 |
NEK11 |
0.731 | 0.119 | 1 | 0.273 |
TAK1 |
0.730 | 0.238 | 1 | 0.285 |
BRSK2 |
0.730 | -0.057 | -3 | 0.494 |
PAK6 |
0.730 | -0.002 | -2 | 0.676 |
PRP4 |
0.730 | -0.045 | -3 | 0.541 |
TTBK1 |
0.729 | 0.012 | 2 | 0.635 |
GAK |
0.729 | 0.036 | 1 | 0.173 |
MELK |
0.729 | -0.097 | -3 | 0.479 |
HIPK3 |
0.729 | -0.053 | 1 | 0.152 |
DYRK1B |
0.729 | -0.058 | 1 | 0.105 |
MAPKAPK5 |
0.729 | -0.080 | -3 | 0.446 |
PKG2 |
0.728 | -0.011 | -2 | 0.637 |
MST1 |
0.728 | 0.217 | 1 | 0.330 |
NEK5 |
0.728 | -0.018 | 1 | 0.210 |
DRAK1 |
0.728 | -0.107 | 1 | 0.135 |
MARK3 |
0.728 | -0.022 | 4 | 0.786 |
MYLK4 |
0.728 | -0.041 | -2 | 0.745 |
P70S6K |
0.728 | -0.014 | -3 | 0.425 |
PAK2 |
0.727 | -0.045 | -2 | 0.740 |
MPSK1 |
0.727 | -0.024 | 1 | 0.154 |
MARK2 |
0.727 | -0.030 | 4 | 0.757 |
PKCT |
0.727 | -0.015 | 2 | 0.782 |
DCAMKL1 |
0.726 | -0.057 | -3 | 0.468 |
DYRK1A |
0.726 | -0.062 | 1 | 0.139 |
NEK4 |
0.726 | 0.142 | 1 | 0.306 |
GSK3A |
0.726 | 0.027 | 4 | 0.550 |
WNK4 |
0.726 | -0.015 | -2 | 0.850 |
PINK1 |
0.726 | -0.135 | 1 | 0.156 |
AKT1 |
0.725 | -0.005 | -3 | 0.415 |
CAMK1G |
0.725 | -0.082 | -3 | 0.474 |
GSK3B |
0.725 | 0.037 | 4 | 0.542 |
CAMKK1 |
0.724 | -0.010 | -2 | 0.806 |
TAO2 |
0.724 | 0.057 | 2 | 0.885 |
PASK |
0.724 | -0.038 | -3 | 0.571 |
SNRK |
0.724 | -0.103 | 2 | 0.686 |
DYRK3 |
0.724 | -0.053 | 1 | 0.125 |
PLK2 |
0.723 | -0.001 | -3 | 0.601 |
EEF2K |
0.723 | 0.047 | 3 | 0.756 |
CDK6 |
0.723 | -0.038 | 1 | 0.120 |
IRAK4 |
0.723 | -0.072 | 1 | 0.187 |
SSTK |
0.722 | -0.022 | 4 | 0.803 |
CHK1 |
0.722 | -0.079 | -3 | 0.483 |
PKACA |
0.722 | -0.009 | -2 | 0.582 |
MAP3K15 |
0.722 | 0.061 | 1 | 0.234 |
CDK4 |
0.721 | -0.042 | 1 | 0.121 |
MARK1 |
0.721 | -0.043 | 4 | 0.803 |
PKCI |
0.721 | -0.011 | 2 | 0.794 |
SLK |
0.721 | 0.100 | -2 | 0.738 |
NEK8 |
0.721 | -0.022 | 2 | 0.845 |
PDK1 |
0.720 | -0.004 | 1 | 0.221 |
LOK |
0.720 | 0.098 | -2 | 0.790 |
LKB1 |
0.719 | -0.021 | -3 | 0.566 |
MEKK6 |
0.719 | 0.029 | 1 | 0.231 |
YSK1 |
0.717 | 0.074 | 2 | 0.855 |
PKCE |
0.717 | -0.002 | 2 | 0.762 |
CAMKK2 |
0.717 | -0.028 | -2 | 0.798 |
ERK7 |
0.716 | -0.018 | 2 | 0.587 |
SGK1 |
0.716 | -0.001 | -3 | 0.357 |
AKT3 |
0.715 | -0.010 | -3 | 0.362 |
PAK5 |
0.715 | -0.023 | -2 | 0.610 |
SMMLCK |
0.715 | -0.063 | -3 | 0.520 |
IRAK1 |
0.715 | -0.083 | -1 | 0.682 |
OSR1 |
0.714 | 0.085 | 2 | 0.865 |
PKN1 |
0.714 | -0.037 | -3 | 0.426 |
DCAMKL2 |
0.714 | -0.077 | -3 | 0.480 |
NEK1 |
0.713 | 0.005 | 1 | 0.231 |
MAK |
0.713 | -0.027 | -2 | 0.716 |
MRCKB |
0.712 | 0.022 | -3 | 0.444 |
MRCKA |
0.712 | 0.026 | -3 | 0.461 |
ROCK2 |
0.710 | 0.032 | -3 | 0.487 |
CAMK1D |
0.710 | -0.071 | -3 | 0.387 |
PAK4 |
0.710 | -0.027 | -2 | 0.618 |
CK1G2 |
0.709 | 0.213 | -3 | 0.739 |
LRRK2 |
0.708 | -0.029 | 2 | 0.878 |
CHK2 |
0.708 | -0.030 | -3 | 0.361 |
MOK |
0.707 | -0.052 | 1 | 0.112 |
RIPK2 |
0.707 | -0.066 | 1 | 0.236 |
DAPK3 |
0.707 | -0.063 | -3 | 0.504 |
PBK |
0.706 | -0.050 | 1 | 0.164 |
VRK1 |
0.706 | -0.073 | 2 | 0.843 |
STK33 |
0.706 | -0.064 | 2 | 0.636 |
NEK3 |
0.705 | -0.015 | 1 | 0.228 |
MEK2 |
0.705 | -0.028 | 2 | 0.858 |
MYO3A |
0.705 | 0.134 | 1 | 0.305 |
YANK3 |
0.703 | 0.048 | 2 | 0.400 |
DAPK1 |
0.703 | -0.060 | -3 | 0.505 |
TAO1 |
0.702 | 0.065 | 1 | 0.276 |
TTK |
0.702 | 0.034 | -2 | 0.835 |
HASPIN |
0.702 | -0.019 | -1 | 0.635 |
ROCK1 |
0.700 | 0.019 | -3 | 0.461 |
MYO3B |
0.699 | 0.049 | 2 | 0.860 |
PDHK3_TYR |
0.699 | 0.034 | 4 | 0.895 |
CAMK1A |
0.699 | -0.065 | -3 | 0.373 |
ASK1 |
0.698 | 0.017 | 1 | 0.228 |
STLK3 |
0.698 | 0.067 | 1 | 0.243 |
DMPK1 |
0.697 | -0.013 | -3 | 0.465 |
BMPR2_TYR |
0.696 | 0.068 | -1 | 0.882 |
SBK |
0.696 | -0.046 | -3 | 0.307 |
PDHK4_TYR |
0.696 | 0.048 | 2 | 0.905 |
BIKE |
0.696 | -0.049 | 1 | 0.143 |
MAP2K6_TYR |
0.696 | 0.057 | -1 | 0.869 |
CRIK |
0.695 | -0.008 | -3 | 0.408 |
ALPHAK3 |
0.694 | -0.015 | -1 | 0.765 |
MAP2K4_TYR |
0.694 | 0.008 | -1 | 0.856 |
PDHK1_TYR |
0.693 | 0.042 | -1 | 0.881 |
PKG1 |
0.692 | -0.033 | -2 | 0.555 |
BUB1 |
0.691 | -0.071 | -5 | 0.770 |
TESK1_TYR |
0.690 | -0.063 | 3 | 0.777 |
MAP2K7_TYR |
0.690 | -0.023 | 2 | 0.881 |
TYK2 |
0.689 | 0.091 | 1 | 0.249 |
RET |
0.688 | 0.057 | 1 | 0.230 |
NEK10_TYR |
0.688 | 0.087 | 1 | 0.267 |
AAK1 |
0.687 | -0.032 | 1 | 0.121 |
PINK1_TYR |
0.686 | -0.094 | 1 | 0.172 |
PKMYT1_TYR |
0.686 | -0.100 | 3 | 0.750 |
JAK1 |
0.685 | 0.109 | 1 | 0.276 |
JAK2 |
0.685 | 0.058 | 1 | 0.243 |
FGR |
0.684 | -0.006 | 1 | 0.169 |
JAK3 |
0.683 | -0.007 | 1 | 0.177 |
EPHA6 |
0.683 | -0.026 | -1 | 0.853 |
ABL2 |
0.682 | 0.002 | -1 | 0.756 |
INSRR |
0.682 | 0.020 | 3 | 0.626 |
CSF1R |
0.682 | 0.013 | 3 | 0.669 |
MST1R |
0.680 | -0.006 | 3 | 0.692 |
ROS1 |
0.680 | 0.011 | 3 | 0.668 |
LIMK2_TYR |
0.680 | -0.097 | -3 | 0.571 |
YANK2 |
0.679 | 0.058 | 2 | 0.423 |
LCK |
0.679 | -0.005 | -1 | 0.807 |
TXK |
0.679 | -0.043 | 1 | 0.132 |
ABL1 |
0.678 | -0.005 | -1 | 0.741 |
FLT1 |
0.677 | 0.031 | -1 | 0.853 |
EPHB4 |
0.677 | -0.064 | -1 | 0.811 |
BLK |
0.677 | -0.026 | -1 | 0.813 |
FLT3 |
0.676 | -0.001 | 3 | 0.684 |
YES1 |
0.676 | -0.072 | -1 | 0.797 |
KIT |
0.676 | 0.005 | 3 | 0.666 |
HCK |
0.676 | -0.036 | -1 | 0.794 |
LIMK1_TYR |
0.674 | -0.158 | 2 | 0.878 |
SYK |
0.674 | 0.069 | -1 | 0.821 |
FYN |
0.674 | 0.002 | -1 | 0.801 |
ERBB2 |
0.673 | 0.007 | 1 | 0.206 |
TNNI3K_TYR |
0.673 | -0.035 | 1 | 0.182 |
KDR |
0.672 | -0.016 | 3 | 0.624 |
FER |
0.672 | -0.104 | 1 | 0.171 |
TYRO3 |
0.671 | -0.101 | 3 | 0.691 |
EGFR |
0.671 | -0.016 | 1 | 0.142 |
SRMS |
0.670 | -0.084 | 1 | 0.171 |
EPHA4 |
0.670 | -0.063 | 2 | 0.782 |
FGFR2 |
0.670 | -0.071 | 3 | 0.657 |
EPHB2 |
0.669 | -0.068 | -1 | 0.794 |
PDGFRB |
0.668 | -0.097 | 3 | 0.688 |
EPHB1 |
0.668 | -0.093 | 1 | 0.174 |
DDR1 |
0.668 | -0.153 | 4 | 0.809 |
MET |
0.667 | -0.037 | 3 | 0.654 |
ITK |
0.667 | -0.099 | -1 | 0.746 |
EPHB3 |
0.666 | -0.093 | -1 | 0.789 |
FRK |
0.665 | -0.022 | -1 | 0.793 |
FGFR1 |
0.665 | -0.089 | 3 | 0.636 |
BMX |
0.665 | -0.056 | -1 | 0.665 |
PTK2 |
0.664 | 0.020 | -1 | 0.846 |
NTRK1 |
0.664 | -0.067 | -1 | 0.789 |
FGFR3 |
0.663 | -0.043 | 3 | 0.624 |
PDGFRA |
0.663 | -0.077 | 3 | 0.690 |
INSR |
0.662 | -0.056 | 3 | 0.620 |
BTK |
0.662 | -0.091 | -1 | 0.680 |
FLT4 |
0.662 | -0.055 | 3 | 0.631 |
ERBB4 |
0.662 | 0.011 | 1 | 0.143 |
FGFR4 |
0.662 | -0.001 | -1 | 0.753 |
LYN |
0.661 | -0.051 | 3 | 0.623 |
TEC |
0.661 | -0.080 | -1 | 0.651 |
TNK1 |
0.660 | -0.095 | 3 | 0.682 |
WEE1_TYR |
0.660 | -0.056 | -1 | 0.683 |
SRC |
0.660 | -0.058 | -1 | 0.778 |
TNK2 |
0.660 | -0.132 | 3 | 0.633 |
EPHA7 |
0.659 | -0.079 | 2 | 0.790 |
TEK |
0.659 | -0.112 | 3 | 0.614 |
ZAP70 |
0.658 | 0.046 | -1 | 0.727 |
MERTK |
0.658 | -0.114 | 3 | 0.641 |
ALK |
0.657 | -0.080 | 3 | 0.600 |
NTRK2 |
0.657 | -0.111 | 3 | 0.627 |
NTRK3 |
0.656 | -0.099 | -1 | 0.744 |
EPHA3 |
0.656 | -0.078 | 2 | 0.752 |
EPHA8 |
0.656 | -0.064 | -1 | 0.793 |
EPHA5 |
0.655 | -0.066 | 2 | 0.769 |
PTK6 |
0.654 | -0.116 | -1 | 0.659 |
AXL |
0.654 | -0.136 | 3 | 0.643 |
LTK |
0.654 | -0.102 | 3 | 0.617 |
MATK |
0.654 | -0.056 | -1 | 0.690 |
DDR2 |
0.652 | -0.104 | 3 | 0.601 |
EPHA1 |
0.652 | -0.093 | 3 | 0.627 |
CSK |
0.651 | -0.065 | 2 | 0.784 |
IGF1R |
0.650 | -0.046 | 3 | 0.558 |
MUSK |
0.650 | -0.093 | 1 | 0.145 |
EPHA2 |
0.648 | -0.061 | -1 | 0.773 |
PTK2B |
0.642 | -0.145 | -1 | 0.694 |
FES |
0.628 | -0.102 | -1 | 0.639 |