Motif 432 (n=74)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AV96 | RBM47 | S540 | ochoa | RNA-binding protein 47 (RNA-binding motif protein 47) | Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing (PubMed:24038582, PubMed:24916387, PubMed:27050523, PubMed:30844405, PubMed:31358901, PubMed:34160127). Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24038582, PubMed:24916387, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:34160127). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (PubMed:27050523, PubMed:31358901). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). {ECO:0000250|UniProtKB:A0A8M1NHK4, ECO:0000269|PubMed:24038582, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:27050523, ECO:0000269|PubMed:30844405, ECO:0000269|PubMed:31358901, ECO:0000269|PubMed:34160127}. |
| A6NC98 | CCDC88B | S1379 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| O00221 | NFKBIE | S177 | ochoa | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}. |
| O00512 | BCL9 | S153 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O43303 | CCP110 | S510 | ochoa | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}. |
| O43683 | BUB1 | S602 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60583 | CCNT2 | S474 | ochoa | Cyclin-T2 (CycT2) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}. |
| O60664 | PLIN3 | S31 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60716 | CTNND1 | S168 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O94913 | PCF11 | S181 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| P0DMU7 | CT45A6 | S114 | ochoa | Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) | None |
| P0DMU8 | CT45A5 | S114 | ochoa | Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) | None |
| P0DMV0 | CT45A7 | S114 | ochoa | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | None |
| P0DPH7 | TUBA3C | T271 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T271 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P27448 | MARK3 | S540 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P35568 | IRS1 | S1100 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35749 | MYH11 | S637 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P49792 | RANBP2 | S2804 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P68363 | TUBA1B | T271 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | T271 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q02750 | MAP2K1 | S298 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| Q12789 | GTF3C1 | S1865 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q13094 | LCP2 | S338 | ochoa | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q14684 | RRP1B | S661 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14694 | USP10 | Y364 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q5FWE3 | PRRT3 | S900 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5HYN5 | CT45A1 | S114 | ochoa | Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) | None |
| Q66K74 | MAP1S | S546 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6NUJ5 | PWWP2B | S453 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6PEY2 | TUBA3E | T271 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6ZUM4 | ARHGAP27 | S455 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q71U36 | TUBA1A | T271 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q86SQ0 | PHLDB2 | S562 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86V48 | LUZP1 | S531 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86XP1 | DGKH | S691 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q8IX01 | SUGP2 | S572 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IZW8 | TNS4 | S359 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N1W1 | ARHGEF28 | S735 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N8S7 | ENAH | S485 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8ND82 | ZNF280C | S114 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
| Q8NHU0 | CT45A3 | S114 | ochoa | Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) | None |
| Q8TEQ0 | SNX29 | S444 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TES7 | FBF1 | S505 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TEV9 | SMCR8 | S401 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WZ73 | RFFL | Y29 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q92750 | TAF4B | S230 | ochoa | Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) | Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}. |
| Q96EB6 | SIRT1 | S539 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96F86 | EDC3 | S109 | ochoa|psp | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96I24 | FUBP3 | S538 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96PN7 | TRERF1 | S618 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96R06 | SPAG5 | S109 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q99567 | NUP88 | S44 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99567 | NUP88 | S167 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q9BQE3 | TUBA1C | T271 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BTA9 | WAC | S445 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BWH6 | RPAP1 | S200 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BX63 | BRIP1 | S122 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXK1 | KLF16 | S108 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9C0F1 | CEP44 | S342 | ochoa | Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3) | Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111). {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}. |
| Q9H3P7 | ACBD3 | S315 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9NPI6 | DCP1A | S367 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9P1T7 | MDFIC | S137 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Q9UHB6 | LIMA1 | S368 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9ULU4 | ZMYND8 | S438 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UPQ0 | LIMCH1 | S656 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQR0 | SCML2 | S255 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y2K5 | R3HDM2 | S348 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y426 | C2CD2 | S435 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y4H2 | IRS2 | S1148 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6Y8 | SEC23IP | S737 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| P41091 | EIF2S3 | S107 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| Q15642 | TRIP10 | S495 | Sugiyama | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q7RTN6 | STRADA | S46 | Sugiyama | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.362899e-11 | 10.627 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 3.212797e-11 | 10.493 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.714396e-11 | 10.243 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.007915e-10 | 9.697 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.156569e-10 | 9.288 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.747384e-10 | 9.324 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.480434e-10 | 9.072 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.216357e-09 | 8.915 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.459118e-09 | 8.836 |
| R-HSA-190861 | Gap junction assembly | 1.712769e-09 | 8.766 |
| R-HSA-9646399 | Aggrephagy | 4.352169e-09 | 8.361 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.780914e-09 | 8.238 |
| R-HSA-68877 | Mitotic Prometaphase | 8.170500e-09 | 8.088 |
| R-HSA-190828 | Gap junction trafficking | 8.660684e-09 | 8.062 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.267572e-08 | 7.897 |
| R-HSA-437239 | Recycling pathway of L1 | 1.267572e-08 | 7.897 |
| R-HSA-9833482 | PKR-mediated signaling | 1.469735e-08 | 7.833 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.423064e-08 | 7.847 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.614958e-08 | 7.792 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.408071e-08 | 7.618 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.091900e-08 | 7.510 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.178569e-08 | 7.498 |
| R-HSA-9663891 | Selective autophagy | 3.091900e-08 | 7.510 |
| R-HSA-983189 | Kinesins | 5.320097e-08 | 7.274 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.466173e-08 | 7.189 |
| R-HSA-9609690 | HCMV Early Events | 1.120125e-07 | 6.951 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.123229e-07 | 6.950 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.455691e-07 | 6.837 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.720596e-07 | 6.764 |
| R-HSA-68882 | Mitotic Anaphase | 2.619995e-07 | 6.582 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.722472e-07 | 6.565 |
| R-HSA-373760 | L1CAM interactions | 2.827484e-07 | 6.549 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.990736e-07 | 6.524 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.820948e-07 | 6.418 |
| R-HSA-5620924 | Intraflagellar transport | 3.955906e-07 | 6.403 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.329875e-07 | 6.273 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.329875e-07 | 6.273 |
| R-HSA-68886 | M Phase | 6.508151e-07 | 6.187 |
| R-HSA-391251 | Protein folding | 7.958565e-07 | 6.099 |
| R-HSA-9609646 | HCMV Infection | 8.810202e-07 | 6.055 |
| R-HSA-5617833 | Cilium Assembly | 9.483402e-07 | 6.023 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.091021e-06 | 5.962 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.091021e-06 | 5.962 |
| R-HSA-1632852 | Macroautophagy | 1.206215e-06 | 5.919 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.660038e-06 | 5.780 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.561394e-06 | 5.806 |
| R-HSA-9612973 | Autophagy | 2.450828e-06 | 5.611 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.410928e-06 | 5.267 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.473716e-06 | 5.262 |
| R-HSA-69275 | G2/M Transition | 8.056671e-06 | 5.094 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.639360e-06 | 5.064 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.003459e-06 | 5.046 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.293708e-05 | 4.888 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.380434e-05 | 4.860 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.938534e-05 | 4.713 |
| R-HSA-422475 | Axon guidance | 2.030400e-05 | 4.692 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.895983e-05 | 4.538 |
| R-HSA-913531 | Interferon Signaling | 2.930321e-05 | 4.533 |
| R-HSA-9675108 | Nervous system development | 3.756432e-05 | 4.425 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.524955e-05 | 4.344 |
| R-HSA-1640170 | Cell Cycle | 5.326621e-05 | 4.274 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.212243e-04 | 3.916 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.508717e-04 | 3.821 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 2.923492e-04 | 3.534 |
| R-HSA-162582 | Signal Transduction | 4.080777e-04 | 3.389 |
| R-HSA-199991 | Membrane Trafficking | 4.219793e-04 | 3.375 |
| R-HSA-74713 | IRS activation | 5.693706e-04 | 3.245 |
| R-HSA-112412 | SOS-mediated signalling | 1.150954e-03 | 2.939 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.487275e-03 | 2.828 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.507785e-03 | 2.822 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.511812e-03 | 2.821 |
| R-HSA-198203 | PI3K/AKT activation | 1.926674e-03 | 2.715 |
| R-HSA-74749 | Signal attenuation | 1.926674e-03 | 2.715 |
| R-HSA-2586552 | Signaling by Leptin | 1.926674e-03 | 2.715 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.378113e-03 | 2.624 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.514302e-03 | 2.600 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.280962e-03 | 2.277 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.280962e-03 | 2.277 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 4.901753e-03 | 2.310 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.916795e-03 | 2.228 |
| R-HSA-109582 | Hemostasis | 5.972275e-03 | 2.224 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.572664e-03 | 2.121 |
| R-HSA-380287 | Centrosome maturation | 8.091011e-03 | 2.092 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.111167e-03 | 2.091 |
| R-HSA-982772 | Growth hormone receptor signaling | 9.114479e-03 | 2.040 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 9.764461e-03 | 2.010 |
| R-HSA-9824446 | Viral Infection Pathways | 9.991517e-03 | 2.000 |
| R-HSA-112316 | Neuronal System | 1.027080e-02 | 1.988 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.034951e-02 | 1.985 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.067911e-02 | 1.971 |
| R-HSA-162587 | HIV Life Cycle | 1.098906e-02 | 1.959 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.373923e-02 | 1.862 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.131193e-02 | 1.946 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.131193e-02 | 1.946 |
| R-HSA-2262752 | Cellular responses to stress | 1.245747e-02 | 1.905 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.446753e-02 | 1.840 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.446753e-02 | 1.840 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 1.461133e-02 | 1.835 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.597309e-02 | 1.797 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.597309e-02 | 1.797 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.675000e-02 | 1.776 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.675000e-02 | 1.776 |
| R-HSA-5673000 | RAF activation | 1.754277e-02 | 1.756 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.754277e-02 | 1.756 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.755985e-02 | 1.755 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.835123e-02 | 1.736 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.173863e-02 | 1.663 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.262304e-02 | 1.645 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.001455e-02 | 1.699 |
| R-HSA-202433 | Generation of second messenger molecules | 2.262304e-02 | 1.645 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.001455e-02 | 1.699 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.839846e-02 | 1.735 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.262304e-02 | 1.645 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.262304e-02 | 1.645 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.352214e-02 | 1.629 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.086908e-02 | 1.680 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.173863e-02 | 1.663 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.001455e-02 | 1.699 |
| R-HSA-8875513 | MET interacts with TNS proteins | 2.423490e-02 | 1.616 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.443578e-02 | 1.612 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.443578e-02 | 1.612 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.443578e-02 | 1.612 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.684724e-02 | 1.571 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.823253e-02 | 1.549 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 2.901183e-02 | 1.537 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 2.901183e-02 | 1.537 |
| R-HSA-3371556 | Cellular response to heat stress | 2.907850e-02 | 1.536 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.921648e-02 | 1.534 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.921648e-02 | 1.534 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.921648e-02 | 1.534 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.921648e-02 | 1.534 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.921648e-02 | 1.534 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 3.849652e-02 | 1.415 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 4.320451e-02 | 1.364 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 4.788973e-02 | 1.320 |
| R-HSA-72731 | Recycling of eIF2:GDP | 4.788973e-02 | 1.320 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.552337e-02 | 1.342 |
| R-HSA-112399 | IRS-mediated signalling | 4.090402e-02 | 1.388 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 4.788973e-02 | 1.320 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 3.849652e-02 | 1.415 |
| R-HSA-191859 | snRNP Assembly | 4.319031e-02 | 1.365 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.319031e-02 | 1.365 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.552337e-02 | 1.342 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.204125e-02 | 1.376 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 3.849652e-02 | 1.415 |
| R-HSA-109704 | PI3K Cascade | 3.328669e-02 | 1.478 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.090402e-02 | 1.388 |
| R-HSA-162906 | HIV Infection | 3.357935e-02 | 1.474 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.670709e-02 | 1.331 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.819006e-02 | 1.317 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.319031e-02 | 1.365 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.362234e-02 | 1.473 |
| R-HSA-166520 | Signaling by NTRKs | 4.860796e-02 | 1.313 |
| R-HSA-1280218 | Adaptive Immune System | 3.568094e-02 | 1.448 |
| R-HSA-5663205 | Infectious disease | 3.818030e-02 | 1.418 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.910824e-02 | 1.309 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.910824e-02 | 1.309 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.032539e-02 | 1.298 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.032539e-02 | 1.298 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 5.255230e-02 | 1.279 |
| R-HSA-167172 | Transcription of the HIV genome | 5.404158e-02 | 1.267 |
| R-HSA-1266738 | Developmental Biology | 5.426288e-02 | 1.265 |
| R-HSA-9610379 | HCMV Late Events | 5.522685e-02 | 1.258 |
| R-HSA-9613354 | Lipophagy | 5.719232e-02 | 1.243 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 5.719232e-02 | 1.243 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.752458e-02 | 1.240 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 6.180991e-02 | 1.209 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 6.180991e-02 | 1.209 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 6.180991e-02 | 1.209 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 7.097819e-02 | 1.149 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 7.552911e-02 | 1.122 |
| R-HSA-9027284 | Erythropoietin activates RAS | 8.905019e-02 | 1.050 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 8.905019e-02 | 1.050 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 8.905019e-02 | 1.050 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 9.795558e-02 | 1.009 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.111527e-01 | 0.954 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.111527e-01 | 0.954 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.155093e-01 | 0.937 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.155093e-01 | 0.937 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.155093e-01 | 0.937 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.155093e-01 | 0.937 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.257580e-02 | 1.139 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 7.097819e-02 | 1.149 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 9.795558e-02 | 1.009 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.962820e-02 | 1.099 |
| R-HSA-9762292 | Regulation of CDH11 function | 6.180991e-02 | 1.209 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 6.640516e-02 | 1.178 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.044313e-02 | 1.219 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.678190e-02 | 1.115 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 9.795558e-02 | 1.009 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 9.795558e-02 | 1.009 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.175347e-02 | 1.209 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 9.282886e-02 | 1.032 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.067750e-01 | 0.972 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.129084e-01 | 0.947 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 6.640516e-02 | 1.178 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 1.067750e-01 | 0.972 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.020882e-02 | 1.154 |
| R-HSA-170968 | Frs2-mediated activation | 8.005801e-02 | 1.097 |
| R-HSA-9842663 | Signaling by LTK | 7.552911e-02 | 1.122 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.984220e-02 | 1.047 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.581775e-02 | 1.182 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 8.905019e-02 | 1.050 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 8.905019e-02 | 1.050 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 7.552911e-02 | 1.122 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.065447e-01 | 0.972 |
| R-HSA-169893 | Prolonged ERK activation events | 9.351368e-02 | 1.029 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 8.456500e-02 | 1.073 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.914262e-02 | 1.228 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 8.905019e-02 | 1.050 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.155093e-01 | 0.937 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 8.456500e-02 | 1.073 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 9.351368e-02 | 1.029 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.067750e-01 | 0.972 |
| R-HSA-445144 | Signal transduction by L1 | 1.155093e-01 | 0.937 |
| R-HSA-70171 | Glycolysis | 1.035038e-01 | 0.985 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.785209e-02 | 1.238 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.962820e-02 | 1.099 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.307353e-02 | 1.200 |
| R-HSA-2682334 | EPH-Ephrin signaling | 8.984220e-02 | 1.047 |
| R-HSA-597592 | Post-translational protein modification | 6.508546e-02 | 1.187 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 1.023760e-01 | 0.990 |
| R-HSA-1643685 | Disease | 9.573264e-02 | 1.019 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.070994e-01 | 0.970 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.160916e-01 | 0.935 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.160916e-01 | 0.935 |
| R-HSA-211000 | Gene Silencing by RNA | 1.160916e-01 | 0.935 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.176919e-01 | 0.929 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.192977e-01 | 0.923 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.198447e-01 | 0.921 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.209092e-01 | 0.918 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.209092e-01 | 0.918 |
| R-HSA-202403 | TCR signaling | 1.209092e-01 | 0.918 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.234259e-01 | 0.909 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.241483e-01 | 0.906 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.241592e-01 | 0.906 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.241592e-01 | 0.906 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.241592e-01 | 0.906 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.257758e-01 | 0.900 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.284528e-01 | 0.891 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.284528e-01 | 0.891 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.306891e-01 | 0.884 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 1.327256e-01 | 0.877 |
| R-HSA-70326 | Glucose metabolism | 1.356468e-01 | 0.868 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.369778e-01 | 0.863 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.373088e-01 | 0.862 |
| R-HSA-68875 | Mitotic Prophase | 1.406464e-01 | 0.852 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.412093e-01 | 0.850 |
| R-HSA-9839394 | TGFBR3 expression | 1.412093e-01 | 0.850 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.412093e-01 | 0.850 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.454204e-01 | 0.837 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.456858e-01 | 0.837 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.473741e-01 | 0.832 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.496110e-01 | 0.825 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.537814e-01 | 0.813 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.537814e-01 | 0.813 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.579316e-01 | 0.802 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.579316e-01 | 0.802 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.579316e-01 | 0.802 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.579316e-01 | 0.802 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.579316e-01 | 0.802 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.579316e-01 | 0.802 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.593023e-01 | 0.798 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.620617e-01 | 0.790 |
| R-HSA-2424491 | DAP12 signaling | 1.620617e-01 | 0.790 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.620617e-01 | 0.790 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.743323e-01 | 0.759 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.743323e-01 | 0.759 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.743323e-01 | 0.759 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.755464e-01 | 0.756 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.783829e-01 | 0.749 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.783829e-01 | 0.749 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.816288e-01 | 0.741 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.824140e-01 | 0.739 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.824140e-01 | 0.739 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.854181e-01 | 0.732 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.864255e-01 | 0.729 |
| R-HSA-381042 | PERK regulates gene expression | 1.864255e-01 | 0.729 |
| R-HSA-187687 | Signalling to ERKs | 1.864255e-01 | 0.729 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.904175e-01 | 0.720 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.904175e-01 | 0.720 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.904175e-01 | 0.720 |
| R-HSA-163560 | Triglyceride catabolism | 1.904175e-01 | 0.720 |
| R-HSA-8853659 | RET signaling | 1.904175e-01 | 0.720 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.904175e-01 | 0.720 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.943903e-01 | 0.711 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.943903e-01 | 0.711 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.960351e-01 | 0.708 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.983437e-01 | 0.703 |
| R-HSA-8875878 | MET promotes cell motility | 1.983437e-01 | 0.703 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.995917e-01 | 0.700 |
| R-HSA-168256 | Immune System | 1.999340e-01 | 0.699 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.004447e-01 | 0.698 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.022781e-01 | 0.694 |
| R-HSA-201556 | Signaling by ALK | 2.022781e-01 | 0.694 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.022781e-01 | 0.694 |
| R-HSA-392499 | Metabolism of proteins | 2.050690e-01 | 0.688 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 2.061933e-01 | 0.686 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.061933e-01 | 0.686 |
| R-HSA-5260271 | Diseases of Immune System | 2.061933e-01 | 0.686 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.061933e-01 | 0.686 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.085171e-01 | 0.681 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.100896e-01 | 0.678 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.100896e-01 | 0.678 |
| R-HSA-167161 | HIV Transcription Initiation | 2.139670e-01 | 0.670 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.139670e-01 | 0.670 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.139670e-01 | 0.670 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.159985e-01 | 0.666 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.174848e-01 | 0.663 |
| R-HSA-165159 | MTOR signalling | 2.178256e-01 | 0.662 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.216655e-01 | 0.654 |
| R-HSA-2172127 | DAP12 interactions | 2.254868e-01 | 0.647 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.254868e-01 | 0.647 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.292895e-01 | 0.640 |
| R-HSA-5619102 | SLC transporter disorders | 2.300973e-01 | 0.638 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.330739e-01 | 0.633 |
| R-HSA-9675135 | Diseases of DNA repair | 2.330739e-01 | 0.633 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.330739e-01 | 0.633 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.368398e-01 | 0.626 |
| R-HSA-72306 | tRNA processing | 2.373281e-01 | 0.625 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.427601e-01 | 0.615 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.427601e-01 | 0.615 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.427601e-01 | 0.615 |
| R-HSA-9766229 | Degradation of CDH1 | 2.443171e-01 | 0.612 |
| R-HSA-73893 | DNA Damage Bypass | 2.443171e-01 | 0.612 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.517220e-01 | 0.599 |
| R-HSA-168255 | Influenza Infection | 2.536407e-01 | 0.596 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.553976e-01 | 0.593 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.553976e-01 | 0.593 |
| R-HSA-72187 | mRNA 3'-end processing | 2.553976e-01 | 0.593 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.553976e-01 | 0.593 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.553976e-01 | 0.593 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.590553e-01 | 0.587 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.590553e-01 | 0.587 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.590553e-01 | 0.587 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.590553e-01 | 0.587 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.609027e-01 | 0.584 |
| R-HSA-72649 | Translation initiation complex formation | 2.626953e-01 | 0.581 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.663176e-01 | 0.575 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.699223e-01 | 0.569 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.699223e-01 | 0.569 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.699223e-01 | 0.569 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.735096e-01 | 0.563 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.754333e-01 | 0.560 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.770795e-01 | 0.557 |
| R-HSA-8979227 | Triglyceride metabolism | 2.806320e-01 | 0.552 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.841673e-01 | 0.546 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.845114e-01 | 0.546 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.876854e-01 | 0.541 |
| R-HSA-450294 | MAP kinase activation | 2.876854e-01 | 0.541 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.911865e-01 | 0.536 |
| R-HSA-9707616 | Heme signaling | 2.911865e-01 | 0.536 |
| R-HSA-373755 | Semaphorin interactions | 2.946706e-01 | 0.531 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.084386e-01 | 0.511 |
| R-HSA-204005 | COPII-mediated vesicle transport | 3.185902e-01 | 0.497 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.185902e-01 | 0.497 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.185902e-01 | 0.497 |
| R-HSA-448424 | Interleukin-17 signaling | 3.185902e-01 | 0.497 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.185902e-01 | 0.497 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.219412e-01 | 0.492 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.219412e-01 | 0.492 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.252760e-01 | 0.488 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.252760e-01 | 0.488 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.252760e-01 | 0.488 |
| R-HSA-418990 | Adherens junctions interactions | 3.260843e-01 | 0.487 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.318971e-01 | 0.479 |
| R-HSA-8852135 | Protein ubiquitination | 3.351835e-01 | 0.475 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.439906e-01 | 0.463 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.449473e-01 | 0.462 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.513777e-01 | 0.454 |
| R-HSA-6806834 | Signaling by MET | 3.513777e-01 | 0.454 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.545695e-01 | 0.450 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.775860e-01 | 0.423 |
| R-HSA-421270 | Cell-cell junction organization | 3.845743e-01 | 0.415 |
| R-HSA-5688426 | Deubiquitination | 3.915299e-01 | 0.407 |
| R-HSA-5389840 | Mitochondrial translation elongation | 4.094406e-01 | 0.388 |
| R-HSA-8953854 | Metabolism of RNA | 4.110966e-01 | 0.386 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.123501e-01 | 0.385 |
| R-HSA-5368286 | Mitochondrial translation initiation | 4.152455e-01 | 0.382 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.152455e-01 | 0.382 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.152455e-01 | 0.382 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.152455e-01 | 0.382 |
| R-HSA-9614085 | FOXO-mediated transcription | 4.181267e-01 | 0.379 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.209940e-01 | 0.376 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.238473e-01 | 0.373 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 4.295123e-01 | 0.367 |
| R-HSA-446728 | Cell junction organization | 4.308248e-01 | 0.366 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.323242e-01 | 0.364 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.461795e-01 | 0.350 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.461795e-01 | 0.350 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.461795e-01 | 0.350 |
| R-HSA-5419276 | Mitochondrial translation termination | 4.489102e-01 | 0.348 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.570229e-01 | 0.340 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.570229e-01 | 0.340 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.570229e-01 | 0.340 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.590156e-01 | 0.338 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.623657e-01 | 0.335 |
| R-HSA-195721 | Signaling by WNT | 4.639088e-01 | 0.334 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.702828e-01 | 0.328 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.702828e-01 | 0.328 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.728961e-01 | 0.325 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.728961e-01 | 0.325 |
| R-HSA-5693538 | Homology Directed Repair | 4.780847e-01 | 0.320 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.806600e-01 | 0.318 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.806600e-01 | 0.318 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.883110e-01 | 0.311 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.883110e-01 | 0.311 |
| R-HSA-1500931 | Cell-Cell communication | 4.927245e-01 | 0.307 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.983395e-01 | 0.302 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.983395e-01 | 0.302 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.983395e-01 | 0.302 |
| R-HSA-194138 | Signaling by VEGF | 4.983395e-01 | 0.302 |
| R-HSA-114608 | Platelet degranulation | 5.032807e-01 | 0.298 |
| R-HSA-69481 | G2/M Checkpoints | 5.032807e-01 | 0.298 |
| R-HSA-9909396 | Circadian clock | 5.178177e-01 | 0.286 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.201994e-01 | 0.284 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.326200e-01 | 0.274 |
| R-HSA-5368287 | Mitochondrial translation | 5.342474e-01 | 0.272 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.365489e-01 | 0.270 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.429981e-01 | 0.265 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.478891e-01 | 0.261 |
| R-HSA-73894 | DNA Repair | 5.589881e-01 | 0.253 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.676153e-01 | 0.246 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.697540e-01 | 0.244 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.718822e-01 | 0.243 |
| R-HSA-9711097 | Cellular response to starvation | 5.802915e-01 | 0.236 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.802915e-01 | 0.236 |
| R-HSA-109581 | Apoptosis | 5.885377e-01 | 0.230 |
| R-HSA-9824439 | Bacterial Infection Pathways | 6.019238e-01 | 0.220 |
| R-HSA-449147 | Signaling by Interleukins | 6.186935e-01 | 0.209 |
| R-HSA-72766 | Translation | 6.514457e-01 | 0.186 |
| R-HSA-74160 | Gene expression (Transcription) | 6.536835e-01 | 0.185 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.660256e-01 | 0.177 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.660256e-01 | 0.177 |
| R-HSA-5357801 | Programmed Cell Death | 6.709731e-01 | 0.173 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.817080e-01 | 0.166 |
| R-HSA-397014 | Muscle contraction | 6.822377e-01 | 0.166 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.535804e-01 | 0.123 |
| R-HSA-416476 | G alpha (q) signalling events | 7.548079e-01 | 0.122 |
| R-HSA-9679506 | SARS-CoV Infections | 7.788215e-01 | 0.109 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.174826e-01 | 0.088 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.584896e-01 | 0.066 |
| R-HSA-212436 | Generic Transcription Pathway | 8.952019e-01 | 0.048 |
| R-HSA-168249 | Innate Immune System | 9.662911e-01 | 0.015 |
| R-HSA-388396 | GPCR downstream signalling | 9.816802e-01 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 9.880769e-01 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 9.937509e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.995791e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999981e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.758 | 0.159 | 1 | 0.418 |
CDC7 |
0.754 | 0.210 | 1 | 0.481 |
HIPK4 |
0.750 | 0.166 | 1 | 0.319 |
RSK2 |
0.747 | 0.149 | -3 | 0.793 |
CLK2 |
0.747 | 0.156 | -3 | 0.774 |
NDR2 |
0.747 | 0.128 | -3 | 0.857 |
SKMLCK |
0.744 | 0.151 | -2 | 0.847 |
MAPKAPK2 |
0.744 | 0.131 | -3 | 0.766 |
DYRK2 |
0.744 | 0.096 | 1 | 0.321 |
PIM3 |
0.744 | 0.107 | -3 | 0.843 |
PRKD1 |
0.743 | 0.111 | -3 | 0.827 |
MTOR |
0.740 | 0.016 | 1 | 0.418 |
COT |
0.740 | 0.056 | 2 | 0.733 |
CAMK1B |
0.739 | 0.089 | -3 | 0.835 |
DYRK4 |
0.739 | 0.088 | 1 | 0.296 |
PRKD2 |
0.739 | 0.122 | -3 | 0.794 |
MOS |
0.739 | 0.095 | 1 | 0.447 |
LATS2 |
0.737 | 0.101 | -5 | 0.856 |
HIPK2 |
0.737 | 0.103 | 1 | 0.268 |
GRK7 |
0.737 | 0.136 | 1 | 0.555 |
P90RSK |
0.737 | 0.104 | -3 | 0.788 |
LATS1 |
0.736 | 0.134 | -3 | 0.874 |
SRPK1 |
0.736 | 0.076 | -3 | 0.758 |
NDR1 |
0.736 | 0.077 | -3 | 0.838 |
PASK |
0.735 | 0.232 | -3 | 0.854 |
DAPK2 |
0.735 | 0.142 | -3 | 0.837 |
CDKL5 |
0.734 | 0.088 | -3 | 0.793 |
BMPR1B |
0.734 | 0.220 | 1 | 0.594 |
MAPKAPK3 |
0.734 | 0.088 | -3 | 0.792 |
MSK1 |
0.734 | 0.113 | -3 | 0.763 |
RSK3 |
0.734 | 0.088 | -3 | 0.785 |
ICK |
0.734 | 0.091 | -3 | 0.829 |
AURC |
0.734 | 0.100 | -2 | 0.671 |
CDKL1 |
0.734 | 0.068 | -3 | 0.796 |
DYRK1B |
0.733 | 0.082 | 1 | 0.331 |
ERK5 |
0.733 | 0.019 | 1 | 0.435 |
CLK4 |
0.733 | 0.099 | -3 | 0.780 |
RSK4 |
0.733 | 0.133 | -3 | 0.785 |
PRPK |
0.733 | -0.013 | -1 | 0.563 |
CAMK2A |
0.732 | 0.115 | 2 | 0.663 |
GRK6 |
0.732 | 0.114 | 1 | 0.544 |
P38B |
0.732 | 0.057 | 1 | 0.354 |
GRK1 |
0.732 | 0.087 | -2 | 0.750 |
TBK1 |
0.732 | -0.046 | 1 | 0.360 |
CAMLCK |
0.732 | 0.076 | -2 | 0.828 |
PKACG |
0.731 | 0.075 | -2 | 0.738 |
CDK1 |
0.731 | 0.039 | 1 | 0.369 |
CLK1 |
0.731 | 0.096 | -3 | 0.763 |
AMPKA1 |
0.731 | 0.057 | -3 | 0.846 |
JNK2 |
0.730 | 0.030 | 1 | 0.320 |
TSSK2 |
0.730 | 0.066 | -5 | 0.843 |
TGFBR1 |
0.730 | 0.130 | -2 | 0.692 |
TSSK1 |
0.730 | 0.061 | -3 | 0.866 |
ATR |
0.730 | 0.018 | 1 | 0.366 |
WNK1 |
0.730 | 0.017 | -2 | 0.865 |
RAF1 |
0.730 | -0.017 | 1 | 0.422 |
HIPK1 |
0.730 | 0.092 | 1 | 0.323 |
NLK |
0.729 | -0.016 | 1 | 0.407 |
KIS |
0.729 | 0.068 | 1 | 0.314 |
AMPKA2 |
0.729 | 0.067 | -3 | 0.829 |
PKACB |
0.729 | 0.106 | -2 | 0.679 |
CAMK2B |
0.728 | 0.080 | 2 | 0.666 |
P70S6KB |
0.728 | 0.072 | -3 | 0.798 |
CAMK2D |
0.728 | 0.044 | -3 | 0.813 |
CHAK2 |
0.728 | 0.015 | -1 | 0.569 |
PAK1 |
0.728 | 0.055 | -2 | 0.795 |
CAMK2G |
0.728 | -0.016 | 2 | 0.676 |
PIM1 |
0.728 | 0.066 | -3 | 0.799 |
HUNK |
0.728 | 0.016 | 2 | 0.709 |
PRKX |
0.727 | 0.122 | -3 | 0.739 |
PDHK4 |
0.727 | -0.082 | 1 | 0.424 |
NUAK2 |
0.727 | 0.056 | -3 | 0.844 |
GRK5 |
0.726 | 0.044 | -3 | 0.787 |
IKKE |
0.726 | -0.075 | 1 | 0.355 |
MARK4 |
0.726 | 0.015 | 4 | 0.794 |
ALK4 |
0.726 | 0.109 | -2 | 0.726 |
DYRK1A |
0.726 | 0.083 | 1 | 0.327 |
CDK19 |
0.726 | 0.031 | 1 | 0.294 |
IKKB |
0.725 | -0.070 | -2 | 0.696 |
CDK3 |
0.725 | 0.032 | 1 | 0.321 |
MSK2 |
0.724 | 0.061 | -3 | 0.755 |
NIK |
0.724 | 0.006 | -3 | 0.837 |
CDK8 |
0.724 | 0.013 | 1 | 0.311 |
P38A |
0.724 | 0.038 | 1 | 0.357 |
CDK7 |
0.724 | 0.009 | 1 | 0.324 |
SRPK2 |
0.723 | 0.060 | -3 | 0.701 |
CDK18 |
0.723 | 0.030 | 1 | 0.312 |
MNK2 |
0.723 | 0.052 | -2 | 0.779 |
MYLK4 |
0.723 | 0.087 | -2 | 0.767 |
CDK2 |
0.722 | 0.027 | 1 | 0.446 |
BMPR2 |
0.722 | -0.109 | -2 | 0.807 |
DRAK1 |
0.722 | 0.191 | 1 | 0.590 |
PKN3 |
0.722 | -0.015 | -3 | 0.822 |
IKKA |
0.722 | -0.018 | -2 | 0.681 |
P38G |
0.721 | 0.015 | 1 | 0.310 |
JNK3 |
0.721 | 0.001 | 1 | 0.333 |
DSTYK |
0.721 | -0.046 | 2 | 0.715 |
DLK |
0.720 | 0.026 | 1 | 0.461 |
PAK3 |
0.720 | 0.016 | -2 | 0.790 |
MAK |
0.720 | 0.129 | -2 | 0.825 |
ACVR2B |
0.720 | 0.142 | -2 | 0.696 |
PKN2 |
0.720 | 0.006 | -3 | 0.814 |
GRK2 |
0.720 | 0.157 | -2 | 0.636 |
PAK6 |
0.720 | 0.056 | -2 | 0.728 |
BRSK1 |
0.719 | 0.061 | -3 | 0.800 |
QSK |
0.719 | 0.038 | 4 | 0.762 |
RIPK3 |
0.719 | -0.075 | 3 | 0.432 |
HIPK3 |
0.719 | 0.071 | 1 | 0.307 |
MARK3 |
0.719 | 0.051 | 4 | 0.744 |
DYRK3 |
0.718 | 0.069 | 1 | 0.306 |
PRKD3 |
0.718 | 0.054 | -3 | 0.762 |
MASTL |
0.718 | -0.083 | -2 | 0.770 |
SRPK3 |
0.718 | 0.040 | -3 | 0.729 |
CDK17 |
0.718 | 0.009 | 1 | 0.316 |
MST4 |
0.718 | -0.044 | 2 | 0.644 |
ERK1 |
0.718 | 0.010 | 1 | 0.325 |
NIM1 |
0.718 | -0.026 | 3 | 0.461 |
CAMK4 |
0.717 | 0.001 | -3 | 0.817 |
AKT2 |
0.717 | 0.073 | -3 | 0.722 |
SGK3 |
0.717 | 0.061 | -3 | 0.781 |
AURB |
0.717 | 0.053 | -2 | 0.663 |
ACVR2A |
0.717 | 0.129 | -2 | 0.683 |
MNK1 |
0.717 | 0.040 | -2 | 0.782 |
P38D |
0.717 | 0.034 | 1 | 0.236 |
DCAMKL1 |
0.717 | 0.051 | -3 | 0.808 |
CK2A2 |
0.717 | 0.103 | 1 | 0.535 |
PKACA |
0.716 | 0.092 | -2 | 0.641 |
GCN2 |
0.716 | -0.119 | 2 | 0.634 |
AURA |
0.716 | 0.060 | -2 | 0.628 |
PDHK1 |
0.716 | -0.136 | 1 | 0.384 |
PAK2 |
0.715 | 0.011 | -2 | 0.777 |
CDK13 |
0.715 | -0.019 | 1 | 0.315 |
PKG2 |
0.715 | 0.055 | -2 | 0.686 |
GSK3B |
0.715 | 0.083 | 4 | 0.517 |
MEK1 |
0.715 | 0.017 | 2 | 0.722 |
CDK5 |
0.715 | -0.002 | 1 | 0.340 |
ALK2 |
0.714 | 0.053 | -2 | 0.703 |
DAPK1 |
0.714 | 0.137 | -3 | 0.785 |
CHK1 |
0.713 | 0.015 | -3 | 0.853 |
PLK1 |
0.713 | 0.027 | -2 | 0.696 |
JNK1 |
0.713 | 0.006 | 1 | 0.349 |
MARK1 |
0.713 | 0.033 | 4 | 0.757 |
CK2A1 |
0.713 | 0.118 | 1 | 0.548 |
DNAPK |
0.713 | -0.023 | 1 | 0.268 |
BMPR1A |
0.712 | 0.129 | 1 | 0.555 |
WNK3 |
0.712 | -0.151 | 1 | 0.354 |
CDK9 |
0.712 | -0.018 | 1 | 0.315 |
MARK2 |
0.712 | 0.023 | 4 | 0.728 |
ULK2 |
0.712 | -0.149 | 2 | 0.633 |
RIPK1 |
0.712 | -0.127 | 1 | 0.356 |
GSK3A |
0.711 | 0.085 | 4 | 0.524 |
PKCD |
0.711 | -0.024 | 2 | 0.591 |
CDK14 |
0.711 | 0.003 | 1 | 0.338 |
GRK4 |
0.711 | -0.043 | -2 | 0.745 |
MELK |
0.710 | -0.012 | -3 | 0.807 |
TGFBR2 |
0.710 | -0.038 | -2 | 0.692 |
PIM2 |
0.710 | 0.055 | -3 | 0.766 |
CDK12 |
0.710 | -0.022 | 1 | 0.304 |
FAM20C |
0.709 | 0.011 | 2 | 0.548 |
BRSK2 |
0.709 | -0.000 | -3 | 0.806 |
MAPKAPK5 |
0.709 | 0.008 | -3 | 0.720 |
NEK6 |
0.709 | -0.077 | -2 | 0.771 |
PLK3 |
0.709 | -0.027 | 2 | 0.675 |
MOK |
0.709 | 0.104 | 1 | 0.332 |
ERK2 |
0.709 | -0.031 | 1 | 0.350 |
CDK10 |
0.709 | 0.012 | 1 | 0.324 |
ULK1 |
0.709 | -0.098 | -3 | 0.730 |
DAPK3 |
0.708 | 0.099 | -3 | 0.805 |
ATM |
0.708 | -0.073 | 1 | 0.321 |
SMG1 |
0.708 | -0.056 | 1 | 0.315 |
QIK |
0.708 | -0.031 | -3 | 0.812 |
CAMK1G |
0.708 | 0.016 | -3 | 0.763 |
NEK7 |
0.708 | -0.143 | -3 | 0.763 |
CDK16 |
0.707 | 0.009 | 1 | 0.317 |
MPSK1 |
0.707 | 0.031 | 1 | 0.321 |
GRK3 |
0.707 | 0.117 | -2 | 0.590 |
SSTK |
0.707 | 0.018 | 4 | 0.767 |
CAMK1D |
0.706 | 0.054 | -3 | 0.724 |
DCAMKL2 |
0.706 | 0.004 | -3 | 0.818 |
PKCB |
0.706 | -0.008 | 2 | 0.535 |
NUAK1 |
0.706 | -0.008 | -3 | 0.808 |
TTBK2 |
0.705 | -0.121 | 2 | 0.587 |
SMMLCK |
0.705 | 0.052 | -3 | 0.800 |
MLK2 |
0.705 | -0.109 | 2 | 0.652 |
SIK |
0.705 | 0.006 | -3 | 0.775 |
YSK4 |
0.705 | -0.083 | 1 | 0.394 |
PAK5 |
0.704 | 0.028 | -2 | 0.672 |
P70S6K |
0.704 | 0.037 | -3 | 0.727 |
VRK2 |
0.704 | -0.165 | 1 | 0.394 |
MLK1 |
0.704 | -0.156 | 2 | 0.614 |
BCKDK |
0.703 | -0.158 | -1 | 0.498 |
PKR |
0.703 | -0.110 | 1 | 0.354 |
PKCG |
0.703 | -0.027 | 2 | 0.541 |
CHAK1 |
0.703 | -0.092 | 2 | 0.644 |
TLK2 |
0.703 | -0.049 | 1 | 0.341 |
PAK4 |
0.702 | 0.030 | -2 | 0.671 |
WNK4 |
0.702 | -0.054 | -2 | 0.857 |
AKT1 |
0.701 | 0.041 | -3 | 0.740 |
NEK9 |
0.701 | -0.165 | 2 | 0.650 |
IRE1 |
0.700 | -0.104 | 1 | 0.316 |
PKCZ |
0.700 | -0.044 | 2 | 0.597 |
SGK1 |
0.700 | 0.073 | -3 | 0.659 |
ANKRD3 |
0.700 | -0.183 | 1 | 0.393 |
GCK |
0.699 | 0.068 | 1 | 0.448 |
NEK2 |
0.699 | -0.094 | 2 | 0.635 |
MST3 |
0.698 | -0.009 | 2 | 0.650 |
BUB1 |
0.698 | 0.099 | -5 | 0.764 |
CAMKK2 |
0.698 | 0.033 | -2 | 0.741 |
MRCKA |
0.698 | 0.056 | -3 | 0.770 |
GAK |
0.698 | -0.002 | 1 | 0.426 |
PKCH |
0.698 | -0.040 | 2 | 0.522 |
PKCA |
0.697 | -0.042 | 2 | 0.522 |
LKB1 |
0.697 | 0.030 | -3 | 0.753 |
MLK3 |
0.697 | -0.092 | 2 | 0.539 |
SBK |
0.697 | 0.071 | -3 | 0.625 |
PLK4 |
0.697 | -0.106 | 2 | 0.563 |
CK1E |
0.696 | 0.015 | -3 | 0.508 |
AKT3 |
0.696 | 0.063 | -3 | 0.672 |
TAO3 |
0.696 | -0.035 | 1 | 0.408 |
PRP4 |
0.696 | -0.018 | -3 | 0.629 |
HPK1 |
0.696 | 0.044 | 1 | 0.434 |
PHKG1 |
0.696 | -0.066 | -3 | 0.819 |
SNRK |
0.695 | -0.097 | 2 | 0.572 |
NEK11 |
0.695 | -0.047 | 1 | 0.407 |
PBK |
0.695 | 0.018 | 1 | 0.353 |
PLK2 |
0.694 | 0.023 | -3 | 0.759 |
MEK5 |
0.693 | -0.138 | 2 | 0.671 |
ROCK2 |
0.693 | 0.060 | -3 | 0.801 |
BRAF |
0.693 | -0.079 | -4 | 0.734 |
CDK4 |
0.691 | -0.028 | 1 | 0.296 |
MEKK3 |
0.691 | -0.129 | 1 | 0.423 |
TLK1 |
0.691 | -0.102 | -2 | 0.726 |
CHK2 |
0.690 | 0.042 | -3 | 0.674 |
CAMKK1 |
0.690 | -0.067 | -2 | 0.731 |
CRIK |
0.689 | 0.067 | -3 | 0.746 |
CK1A2 |
0.688 | 0.009 | -3 | 0.458 |
MRCKB |
0.688 | 0.035 | -3 | 0.752 |
PKCE |
0.688 | 0.003 | 2 | 0.521 |
PDK1 |
0.688 | -0.076 | 1 | 0.349 |
NEK5 |
0.688 | -0.126 | 1 | 0.358 |
CDK6 |
0.688 | -0.042 | 1 | 0.297 |
IRE2 |
0.688 | -0.136 | 2 | 0.572 |
ZAK |
0.687 | -0.141 | 1 | 0.377 |
CAMK1A |
0.687 | 0.028 | -3 | 0.687 |
DMPK1 |
0.687 | 0.070 | -3 | 0.774 |
PERK |
0.687 | -0.155 | -2 | 0.754 |
PKCI |
0.687 | -0.039 | 2 | 0.547 |
CK1D |
0.687 | 0.002 | -3 | 0.452 |
MEKK6 |
0.686 | -0.047 | 1 | 0.379 |
MLK4 |
0.686 | -0.120 | 2 | 0.531 |
TNIK |
0.685 | -0.040 | 3 | 0.593 |
KHS2 |
0.685 | 0.004 | 1 | 0.398 |
MAP3K15 |
0.684 | -0.063 | 1 | 0.359 |
MEKK2 |
0.684 | -0.158 | 2 | 0.637 |
KHS1 |
0.684 | -0.019 | 1 | 0.371 |
PKCT |
0.684 | -0.058 | 2 | 0.532 |
MEKK1 |
0.684 | -0.207 | 1 | 0.352 |
MINK |
0.683 | -0.067 | 1 | 0.373 |
IRAK4 |
0.683 | -0.159 | 1 | 0.293 |
PHKG2 |
0.683 | -0.067 | -3 | 0.793 |
LOK |
0.683 | -0.052 | -2 | 0.752 |
PKN1 |
0.683 | -0.016 | -3 | 0.740 |
MST2 |
0.682 | -0.074 | 1 | 0.425 |
LRRK2 |
0.682 | -0.091 | 2 | 0.673 |
TAO2 |
0.682 | -0.114 | 2 | 0.662 |
HRI |
0.682 | -0.214 | -2 | 0.772 |
SLK |
0.682 | -0.045 | -2 | 0.694 |
HGK |
0.682 | -0.072 | 3 | 0.574 |
ERK7 |
0.682 | -0.052 | 2 | 0.354 |
EEF2K |
0.681 | -0.058 | 3 | 0.534 |
NEK4 |
0.680 | -0.099 | 1 | 0.335 |
STK33 |
0.679 | -0.081 | 2 | 0.521 |
PINK1 |
0.679 | -0.165 | 1 | 0.345 |
PKG1 |
0.679 | 0.017 | -2 | 0.612 |
TTBK1 |
0.678 | -0.144 | 2 | 0.525 |
ROCK1 |
0.678 | 0.035 | -3 | 0.763 |
MST1 |
0.678 | -0.083 | 1 | 0.401 |
TAK1 |
0.678 | -0.103 | 1 | 0.378 |
VRK1 |
0.677 | -0.132 | 2 | 0.704 |
NEK1 |
0.677 | -0.089 | 1 | 0.339 |
CK1G1 |
0.677 | -0.044 | -3 | 0.490 |
NEK8 |
0.677 | -0.168 | 2 | 0.633 |
MEK2 |
0.675 | -0.118 | 2 | 0.684 |
IRAK1 |
0.675 | -0.218 | -1 | 0.474 |
HASPIN |
0.673 | -0.054 | -1 | 0.461 |
YANK3 |
0.673 | -0.017 | 2 | 0.371 |
BIKE |
0.670 | -0.042 | 1 | 0.346 |
PDHK3_TYR |
0.668 | 0.203 | 4 | 0.818 |
ALPHAK3 |
0.666 | -0.061 | -1 | 0.489 |
YSK1 |
0.666 | -0.128 | 2 | 0.604 |
RIPK2 |
0.664 | -0.211 | 1 | 0.337 |
CK1A |
0.662 | 0.038 | -3 | 0.367 |
OSR1 |
0.661 | -0.078 | 2 | 0.638 |
ASK1 |
0.660 | -0.122 | 1 | 0.358 |
AAK1 |
0.660 | -0.025 | 1 | 0.289 |
PDHK4_TYR |
0.657 | 0.078 | 2 | 0.741 |
MYO3B |
0.656 | -0.088 | 2 | 0.638 |
BMPR2_TYR |
0.656 | 0.097 | -1 | 0.542 |
NEK3 |
0.655 | -0.172 | 1 | 0.294 |
MAP2K4_TYR |
0.655 | 0.060 | -1 | 0.555 |
TAO1 |
0.655 | -0.119 | 1 | 0.323 |
MAP2K6_TYR |
0.655 | 0.080 | -1 | 0.562 |
TESK1_TYR |
0.653 | 0.007 | 3 | 0.590 |
TTK |
0.651 | -0.114 | -2 | 0.717 |
MYO3A |
0.650 | -0.123 | 1 | 0.340 |
PDHK1_TYR |
0.650 | 0.017 | -1 | 0.553 |
TXK |
0.650 | 0.133 | 1 | 0.561 |
EPHA6 |
0.650 | 0.010 | -1 | 0.529 |
PKMYT1_TYR |
0.649 | -0.028 | 3 | 0.551 |
PTK2B |
0.648 | 0.140 | -1 | 0.488 |
LIMK2_TYR |
0.648 | 0.002 | -3 | 0.832 |
ABL2 |
0.647 | 0.020 | -1 | 0.513 |
MAP2K7_TYR |
0.647 | -0.120 | 2 | 0.715 |
ABL1 |
0.646 | 0.014 | -1 | 0.510 |
EPHB4 |
0.645 | -0.003 | -1 | 0.491 |
STLK3 |
0.645 | -0.153 | 1 | 0.359 |
DDR1 |
0.645 | -0.032 | 4 | 0.760 |
PINK1_TYR |
0.644 | -0.114 | 1 | 0.433 |
SRMS |
0.643 | 0.039 | 1 | 0.527 |
EPHA4 |
0.642 | 0.013 | 2 | 0.683 |
YANK2 |
0.642 | -0.032 | 2 | 0.373 |
PTK2 |
0.640 | 0.108 | -1 | 0.466 |
RET |
0.639 | -0.130 | 1 | 0.377 |
ITK |
0.639 | 0.020 | -1 | 0.486 |
MERTK |
0.638 | 0.007 | 3 | 0.467 |
EPHB1 |
0.638 | -0.010 | 1 | 0.503 |
FER |
0.638 | -0.030 | 1 | 0.496 |
FGR |
0.638 | -0.031 | 1 | 0.494 |
TNK2 |
0.637 | -0.057 | 3 | 0.433 |
YES1 |
0.637 | -0.062 | -1 | 0.526 |
INSRR |
0.637 | -0.043 | 3 | 0.422 |
MST1R |
0.636 | -0.151 | 3 | 0.500 |
CSF1R |
0.636 | -0.096 | 3 | 0.469 |
TYRO3 |
0.636 | -0.098 | 3 | 0.478 |
EPHB2 |
0.635 | -0.029 | -1 | 0.467 |
LIMK1_TYR |
0.635 | -0.130 | 2 | 0.694 |
AXL |
0.635 | -0.057 | 3 | 0.455 |
FYN |
0.633 | -0.010 | -1 | 0.494 |
FGFR2 |
0.633 | -0.110 | 3 | 0.492 |
DDR2 |
0.633 | -0.004 | 3 | 0.415 |
BMX |
0.632 | -0.012 | -1 | 0.433 |
EPHB3 |
0.632 | -0.064 | -1 | 0.482 |
NEK10_TYR |
0.632 | -0.087 | 1 | 0.295 |
ROS1 |
0.632 | -0.123 | 3 | 0.437 |
JAK2 |
0.630 | -0.170 | 1 | 0.351 |
EPHA7 |
0.630 | -0.035 | 2 | 0.676 |
JAK3 |
0.629 | -0.144 | 1 | 0.383 |
MET |
0.629 | -0.052 | 3 | 0.482 |
KIT |
0.629 | -0.100 | 3 | 0.472 |
TNK1 |
0.629 | -0.098 | 3 | 0.469 |
HCK |
0.628 | -0.122 | -1 | 0.511 |
SYK |
0.628 | 0.060 | -1 | 0.455 |
EPHA3 |
0.628 | -0.055 | 2 | 0.653 |
TYK2 |
0.628 | -0.234 | 1 | 0.361 |
EGFR |
0.627 | -0.022 | 1 | 0.475 |
EPHA8 |
0.626 | -0.022 | -1 | 0.473 |
CSK |
0.626 | -0.044 | 2 | 0.677 |
EPHA5 |
0.626 | -0.034 | 2 | 0.674 |
LCK |
0.626 | -0.094 | -1 | 0.518 |
BLK |
0.625 | -0.089 | -1 | 0.521 |
TEC |
0.625 | -0.056 | -1 | 0.441 |
NTRK1 |
0.625 | -0.102 | -1 | 0.482 |
FGFR3 |
0.624 | -0.112 | 3 | 0.462 |
INSR |
0.624 | -0.081 | 3 | 0.405 |
LTK |
0.624 | -0.098 | 3 | 0.421 |
CK1G3 |
0.624 | -0.059 | -3 | 0.321 |
JAK1 |
0.623 | -0.101 | 1 | 0.339 |
ERBB4 |
0.623 | 0.016 | 1 | 0.540 |
FGFR1 |
0.623 | -0.166 | 3 | 0.435 |
SRC |
0.623 | -0.051 | -1 | 0.496 |
NTRK3 |
0.623 | -0.070 | -1 | 0.457 |
ALK |
0.623 | -0.086 | 3 | 0.389 |
PDGFRB |
0.623 | -0.158 | 3 | 0.471 |
TEK |
0.622 | -0.159 | 3 | 0.414 |
FRK |
0.622 | -0.083 | -1 | 0.516 |
EPHA1 |
0.622 | -0.099 | 3 | 0.453 |
ERBB2 |
0.621 | -0.097 | 1 | 0.478 |
BTK |
0.621 | -0.156 | -1 | 0.462 |
KDR |
0.621 | -0.144 | 3 | 0.439 |
MATK |
0.620 | -0.069 | -1 | 0.462 |
CK1G2 |
0.620 | -0.034 | -3 | 0.410 |
EPHA2 |
0.620 | -0.027 | -1 | 0.434 |
TNNI3K_TYR |
0.619 | -0.069 | 1 | 0.314 |
FLT3 |
0.619 | -0.187 | 3 | 0.470 |
FLT1 |
0.619 | -0.122 | -1 | 0.487 |
PDGFRA |
0.618 | -0.192 | 3 | 0.475 |
FGFR4 |
0.616 | -0.092 | -1 | 0.452 |
MUSK |
0.616 | -0.060 | 1 | 0.483 |
WEE1_TYR |
0.615 | -0.121 | -1 | 0.455 |
IGF1R |
0.615 | -0.065 | 3 | 0.365 |
PTK6 |
0.615 | -0.155 | -1 | 0.447 |
NTRK2 |
0.614 | -0.158 | 3 | 0.431 |
LYN |
0.614 | -0.126 | 3 | 0.398 |
FLT4 |
0.613 | -0.172 | 3 | 0.436 |
FES |
0.612 | -0.008 | -1 | 0.417 |
ZAP70 |
0.611 | 0.019 | -1 | 0.431 |