Motif 431 (n=93)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NKT7 | RGPD3 | S1264 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
E9PCH4 | None | S778 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
O14715 | RGPD8 | S1263 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
O15049 | N4BP3 | S209 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
O15049 | N4BP3 | S210 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
O15231 | ZNF185 | S132 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
O15265 | ATXN7 | S217 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
O43314 | PPIP5K2 | S1221 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
O60238 | BNIP3L | S62 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
O60861 | GAS7 | S162 | ochoa | Growth arrest-specific protein 7 (GAS-7) | May play a role in promoting maturation and morphological differentiation of cerebellar neurons. |
O75385 | ULK1 | S224 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
O75581 | LRP6 | S1474 | ochoa | Low-density lipoprotein receptor-related protein 6 (LRP-6) | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}. |
O75808 | CAPN15 | S337 | ochoa | Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) | None |
O94979 | SEC31A | S351 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
P05549 | TFAP2A | S223 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
P08913 | ADRA2A | S313 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
P11362 | FGFR1 | S452 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
P13489 | RNH1 | S255 | ochoa | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}. |
P21802 | FGFR2 | S452 | ochoa | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
P35269 | GTF2F1 | S398 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
P39880 | CUX1 | S875 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
P49790 | NUP153 | S938 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
P49792 | RANBP2 | S2239 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P50454 | SERPINH1 | S139 | ochoa | Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
P51116 | FXR2 | S446 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
P53814 | SMTN | S713 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
P54132 | BLM | S1379 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
Q03164 | KMT2A | S2316 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q05209 | PTPN12 | S555 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
Q08AD1 | CAMSAP2 | S692 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
Q15018 | ABRAXAS2 | S339 | ochoa | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. |
Q15303 | ERBB4 | S1124 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
Q15643 | TRIP11 | S1858 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
Q16531 | DDB1 | S661 | ochoa | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMed:16482215, PubMed:16940174, PubMed:17079684). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:38316879}. |
Q16649 | NFIL3 | S285 | ochoa | Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}. |
Q16658 | FSCN1 | S120 | ochoa | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
Q5JTV8 | TOR1AIP1 | S263 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
Q5SRE5 | NUP188 | S1530 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
Q5TAQ9 | DCAF8 | S20 | ochoa | DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
Q6QNK2 | ADGRD1 | S829 | ochoa | Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)] | Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271). {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:35447113, ECO:0000269|PubMed:39884271}. |
Q6T4R5 | NHS | S1479 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
Q6UX73 | C16orf89 | S173 | ochoa | UPF0764 protein C16orf89 | None |
Q6VUC0 | TFAP2E | S230 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
Q6ZN18 | AEBP2 | S146 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
Q6ZN18 | AEBP2 | S147 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
Q6ZU67 | BEND4 | S99 | ochoa | BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4) | None |
Q7Z2Z1 | TICRR | S1718 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
Q7Z3J3 | RGPD4 | S1264 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q7Z460 | CLASP1 | S253 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
Q7Z589 | EMSY | S211 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
Q7Z6R9 | TFAP2D | S223 | ochoa | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}. |
Q86XJ1 | GAS2L3 | S621 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
Q8N1W1 | ARHGEF28 | S477 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
Q8N5C8 | TAB3 | S356 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
Q8NEY1 | NAV1 | S697 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
Q8TAT6 | NPLOC4 | S59 | ochoa | Nuclear protein localization protein 4 homolog (Protein NPL4) | The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}. |
Q8TEU7 | RAPGEF6 | S728 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
Q8WVM7 | STAG1 | S1069 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
Q8WXI7 | MUC16 | S9554 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
Q92481 | TFAP2B | S242 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
Q92754 | TFAP2C | S236 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
Q96EZ8 | MCRS1 | S91 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
Q96HI0 | SENP5 | S423 | ochoa | Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. |
Q96NE9 | FRMD6 | S390 | ochoa | FERM domain-containing protein 6 (Willin) | None |
Q96NE9 | FRMD6 | S413 | ochoa | FERM domain-containing protein 6 (Willin) | None |
Q96P11 | NSUN5 | S166 | ochoa | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}. |
Q96PE2 | ARHGEF17 | S568 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q99501 | GAS2L1 | S601 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
Q99666 | RGPD5 | S1263 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
Q9BWT7 | CARD10 | S570 | ochoa | Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}. |
Q9BZF3 | OSBPL6 | S45 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
Q9C040 | TRIM2 | S102 | ochoa | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}. |
Q9C0D0 | PHACTR1 | S186 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
Q9H1B7 | IRF2BPL | S336 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
Q9H201 | EPN3 | S190 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
Q9H201 | EPN3 | S505 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
Q9HCM3 | KIAA1549 | S1913 | ochoa | UPF0606 protein KIAA1549 | May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}. |
Q9NQW6 | ANLN | S140 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
Q9NR09 | BIRC6 | S462 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
Q9NRR5 | UBQLN4 | S317 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
Q9P227 | ARHGAP23 | S1350 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
Q9UH99 | SUN2 | S19 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
Q9UHD8 | SEPTIN9 | S22 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
Q9ULT8 | HECTD1 | S1531 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
Q9UPN3 | MACF1 | S7235 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
Q9UPS6 | SETD1B | S1767 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
Q9UPT5 | EXOC7 | S243 | ochoa | Exocyst complex component 7 (Exocyst complex component Exo70) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:E7FC72}. |
Q9UQ35 | SRRM2 | S819 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y2D8 | SSX2IP | S31 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
Q9Y2F5 | ICE1 | S1330 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
Q9Y5X1 | SNX9 | S199 | ochoa | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
Q9Y6I3 | EPN1 | S419 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
Q9Y6M4 | CSNK1G3 | S33 | ochoa | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-1226099 | Signaling by FGFR in disease | 1.770917e-11 | 10.752 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.189966e-10 | 9.924 |
R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 2.163454e-10 | 9.665 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 2.757850e-08 | 7.559 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.170397e-08 | 7.663 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 2.579259e-08 | 7.589 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 1.925162e-07 | 6.716 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.403049e-07 | 6.131 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.920862e-06 | 5.717 |
R-HSA-109704 | PI3K Cascade | 3.577119e-06 | 5.446 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.253645e-06 | 5.371 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.567021e-06 | 5.254 |
R-HSA-112399 | IRS-mediated signalling | 6.815919e-06 | 5.166 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.377365e-06 | 5.077 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 9.538354e-06 | 5.021 |
R-HSA-190236 | Signaling by FGFR | 1.195917e-05 | 4.922 |
R-HSA-2428924 | IGF1R signaling cascade | 1.210951e-05 | 4.917 |
R-HSA-74751 | Insulin receptor signalling cascade | 1.210951e-05 | 4.917 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.308138e-05 | 4.883 |
R-HSA-9834899 | Specification of the neural plate border | 2.601838e-05 | 4.585 |
R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 3.047169e-05 | 4.516 |
R-HSA-190241 | FGFR2 ligand binding and activation | 3.545941e-05 | 4.450 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.719268e-05 | 4.326 |
R-HSA-1253288 | Downregulation of ERBB4 signaling | 6.690468e-05 | 4.175 |
R-HSA-5654695 | PI-3K cascade:FGFR2 | 6.979094e-05 | 4.156 |
R-HSA-74752 | Signaling by Insulin receptor | 8.286108e-05 | 4.082 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 8.867815e-05 | 4.052 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 9.939887e-05 | 4.003 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.236195e-04 | 3.908 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.236195e-04 | 3.908 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.236195e-04 | 3.908 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 1.675927e-04 | 3.776 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.025570e-04 | 3.693 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 2.218796e-04 | 3.654 |
R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.830533e-04 | 3.548 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 3.312368e-04 | 3.480 |
R-HSA-5673001 | RAF/MAP kinase cascade | 3.068552e-04 | 3.513 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.388904e-04 | 3.470 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.607654e-04 | 3.443 |
R-HSA-5654738 | Signaling by FGFR2 | 3.863810e-04 | 3.413 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 3.961633e-04 | 3.402 |
R-HSA-1250347 | SHC1 events in ERBB4 signaling | 4.427840e-04 | 3.354 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 4.427840e-04 | 3.354 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 4.427840e-04 | 3.354 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.441119e-04 | 3.353 |
R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 5.754741e-04 | 3.240 |
R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 5.754741e-04 | 3.240 |
R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 5.754741e-04 | 3.240 |
R-HSA-2033519 | Activated point mutants of FGFR2 | 5.759389e-04 | 3.240 |
R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 8.249622e-04 | 3.084 |
R-HSA-5683057 | MAPK family signaling cascades | 1.038330e-03 | 2.984 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.234193e-03 | 2.909 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 1.402173e-03 | 2.853 |
R-HSA-1227986 | Signaling by ERBB2 | 1.329600e-03 | 2.876 |
R-HSA-9620244 | Long-term potentiation | 1.355000e-03 | 2.868 |
R-HSA-1257604 | PIP3 activates AKT signaling | 1.589934e-03 | 2.799 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.911634e-03 | 2.719 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.069885e-03 | 2.684 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.236057e-03 | 2.651 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.236057e-03 | 2.651 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.592694e-03 | 2.586 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.592694e-03 | 2.586 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.391739e-03 | 2.621 |
R-HSA-1236394 | Signaling by ERBB4 | 2.612524e-03 | 2.583 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.783417e-03 | 2.555 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.783417e-03 | 2.555 |
R-HSA-180746 | Nuclear import of Rev protein | 2.982575e-03 | 2.525 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.190288e-03 | 2.496 |
R-HSA-1474165 | Reproduction | 3.548766e-03 | 2.450 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.190288e-03 | 2.496 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.631838e-03 | 2.440 |
R-HSA-9006925 | Intracellular signaling by second messengers | 3.712995e-03 | 2.430 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.865896e-03 | 2.413 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.108951e-03 | 2.386 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.108951e-03 | 2.386 |
R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 4.951905e-03 | 2.305 |
R-HSA-1250342 | PI3K events in ERBB4 signaling | 4.951905e-03 | 2.305 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.361106e-03 | 2.360 |
R-HSA-190377 | FGFR2b ligand binding and activation | 4.333022e-03 | 2.363 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.361106e-03 | 2.360 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.361106e-03 | 2.360 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.622458e-03 | 2.335 |
R-HSA-3214841 | PKMTs methylate histone lysines | 4.622458e-03 | 2.335 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.070410e-03 | 2.217 |
R-HSA-9758941 | Gastrulation | 6.206031e-03 | 2.207 |
R-HSA-190375 | FGFR2c ligand binding and activation | 6.303777e-03 | 2.200 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.388839e-03 | 2.195 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 8.013905e-03 | 2.096 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 9.827645e-03 | 2.008 |
R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.032403e-02 | 1.986 |
R-HSA-190242 | FGFR1 ligand binding and activation | 1.123370e-02 | 1.949 |
R-HSA-9827857 | Specification of primordial germ cells | 1.032403e-02 | 1.986 |
R-HSA-194441 | Metabolism of non-coding RNA | 1.144407e-02 | 1.941 |
R-HSA-191859 | snRNP Assembly | 1.144407e-02 | 1.941 |
R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.032403e-02 | 1.986 |
R-HSA-1483249 | Inositol phosphate metabolism | 1.097463e-02 | 1.960 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 1.055306e-02 | 1.977 |
R-HSA-6784531 | tRNA processing in the nucleus | 1.285973e-02 | 1.891 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.335287e-02 | 1.874 |
R-HSA-8848021 | Signaling by PTK6 | 1.335287e-02 | 1.874 |
R-HSA-3371556 | Cellular response to heat stress | 1.456362e-02 | 1.837 |
R-HSA-5654689 | PI-3K cascade:FGFR1 | 1.628230e-02 | 1.788 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.827504e-02 | 1.738 |
R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 1.852603e-02 | 1.732 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.887610e-02 | 1.724 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 1.969405e-02 | 1.706 |
R-HSA-1169408 | ISG15 antiviral mechanism | 2.011090e-02 | 1.697 |
R-HSA-8853333 | Signaling by FGFR2 fusions | 2.046891e-02 | 1.689 |
R-HSA-9018519 | Estrogen-dependent gene expression | 2.189267e-02 | 1.660 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.212004e-02 | 1.655 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.477633e-02 | 1.606 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.150825e-02 | 1.502 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 2.525489e-02 | 1.598 |
R-HSA-1500620 | Meiosis | 2.693944e-02 | 1.570 |
R-HSA-182971 | EGFR downregulation | 2.731916e-02 | 1.564 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.008516e-02 | 1.522 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.228643e-02 | 1.491 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.525489e-02 | 1.598 |
R-HSA-3247509 | Chromatin modifying enzymes | 3.174801e-02 | 1.498 |
R-HSA-9008059 | Interleukin-37 signaling | 2.597711e-02 | 1.585 |
R-HSA-438064 | Post NMDA receptor activation events | 2.920048e-02 | 1.535 |
R-HSA-162587 | HIV Life Cycle | 3.346027e-02 | 1.475 |
R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 3.388362e-02 | 1.470 |
R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 3.388362e-02 | 1.470 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.443249e-02 | 1.463 |
R-HSA-4839726 | Chromatin organization | 3.906836e-02 | 1.408 |
R-HSA-70171 | Glycolysis | 4.195913e-02 | 1.377 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.384056e-02 | 1.358 |
R-HSA-6811438 | Intra-Golgi traffic | 4.544386e-02 | 1.343 |
R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 4.711625e-02 | 1.327 |
R-HSA-168255 | Influenza Infection | 4.874386e-02 | 1.312 |
R-HSA-9700206 | Signaling by ALK in cancer | 4.973352e-02 | 1.303 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.973352e-02 | 1.303 |
R-HSA-211000 | Gene Silencing by RNA | 4.973352e-02 | 1.303 |
R-HSA-5340588 | Signaling by RNF43 mutants | 5.366505e-02 | 1.270 |
R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 5.366505e-02 | 1.270 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.658817e-02 | 1.247 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 6.016925e-02 | 1.221 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 6.662914e-02 | 1.176 |
R-HSA-190370 | FGFR1b ligand binding and activation | 7.304503e-02 | 1.136 |
R-HSA-9700645 | ALK mutants bind TKIs | 7.941721e-02 | 1.100 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 8.574598e-02 | 1.067 |
R-HSA-1221632 | Meiotic synapsis | 6.682154e-02 | 1.175 |
R-HSA-5654736 | Signaling by FGFR1 | 7.259966e-02 | 1.139 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.721319e-02 | 1.173 |
R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 8.574598e-02 | 1.067 |
R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 7.941721e-02 | 1.100 |
R-HSA-8934903 | Receptor Mediated Mitophagy | 8.574598e-02 | 1.067 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 6.662914e-02 | 1.176 |
R-HSA-390696 | Adrenoceptors | 7.304503e-02 | 1.136 |
R-HSA-68882 | Mitotic Anaphase | 8.111220e-02 | 1.091 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.207988e-02 | 1.086 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 8.574598e-02 | 1.067 |
R-HSA-177929 | Signaling by EGFR | 7.259966e-02 | 1.139 |
R-HSA-73893 | DNA Damage Bypass | 5.937423e-02 | 1.226 |
R-HSA-162909 | Host Interactions of HIV factors | 7.076531e-02 | 1.150 |
R-HSA-597592 | Post-translational protein modification | 6.885595e-02 | 1.162 |
R-HSA-1643685 | Disease | 7.724250e-02 | 1.112 |
R-HSA-68875 | Mitotic Prophase | 6.604792e-02 | 1.180 |
R-HSA-70326 | Glucose metabolism | 6.260915e-02 | 1.203 |
R-HSA-75893 | TNF signaling | 7.259966e-02 | 1.139 |
R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 9.203163e-02 | 1.036 |
R-HSA-162906 | HIV Infection | 9.206933e-02 | 1.036 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 9.309910e-02 | 1.031 |
R-HSA-162582 | Signal Transduction | 9.469836e-02 | 1.024 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 9.717877e-02 | 1.012 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 9.827445e-02 | 1.008 |
R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 9.827445e-02 | 1.008 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 9.827445e-02 | 1.008 |
R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.288562e-01 | 0.890 |
R-HSA-5083625 | Defective GALNT3 causes HFTC | 1.288562e-01 | 0.890 |
R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 1.407990e-01 | 0.851 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.525796e-01 | 0.817 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.525796e-01 | 0.817 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.584098e-01 | 0.800 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.584098e-01 | 0.800 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.584098e-01 | 0.800 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.584098e-01 | 0.800 |
R-HSA-6803529 | FGFR2 alternative splicing | 1.756627e-01 | 0.755 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.813354e-01 | 0.742 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.813354e-01 | 0.742 |
R-HSA-977068 | Termination of O-glycan biosynthesis | 1.813354e-01 | 0.742 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.925651e-01 | 0.715 |
R-HSA-141424 | Amplification of signal from the kinetochores | 1.375792e-01 | 0.861 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.375792e-01 | 0.861 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.981225e-01 | 0.703 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.399219e-01 | 0.854 |
R-HSA-5696398 | Nucleotide Excision Repair | 1.932882e-01 | 0.714 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.348480e-01 | 0.870 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.329210e-01 | 0.876 |
R-HSA-190373 | FGFR1c ligand binding and activation | 1.106328e-01 | 0.956 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.981225e-01 | 0.703 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 1.784428e-01 | 0.749 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.228232e-01 | 0.911 |
R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.407990e-01 | 0.851 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.467095e-01 | 0.834 |
R-HSA-68877 | Mitotic Prometaphase | 1.806222e-01 | 0.743 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.167488e-01 | 0.933 |
R-HSA-2467813 | Separation of Sister Chromatids | 1.315951e-01 | 0.881 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.642001e-01 | 0.785 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.869695e-01 | 0.728 |
R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 1.981225e-01 | 0.703 |
R-HSA-110320 | Translesion Synthesis by POLH | 1.525796e-01 | 0.817 |
R-HSA-5617833 | Cilium Assembly | 1.755073e-01 | 0.756 |
R-HSA-68886 | M Phase | 1.464931e-01 | 0.834 |
R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 1.525796e-01 | 0.817 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.584098e-01 | 0.800 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.699510e-01 | 0.770 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.981225e-01 | 0.703 |
R-HSA-5689901 | Metalloprotease DUBs | 1.981225e-01 | 0.703 |
R-HSA-9609690 | HCMV Early Events | 1.857777e-01 | 0.731 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.164647e-01 | 0.934 |
R-HSA-199991 | Membrane Trafficking | 1.795306e-01 | 0.746 |
R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 1.813354e-01 | 0.742 |
R-HSA-3214847 | HATs acetylate histones | 1.759864e-01 | 0.755 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.044747e-01 | 0.981 |
R-HSA-74160 | Gene expression (Transcription) | 1.385536e-01 | 0.858 |
R-HSA-1640170 | Cell Cycle | 1.311340e-01 | 0.882 |
R-HSA-9610379 | HCMV Late Events | 1.209316e-01 | 0.917 |
R-HSA-445144 | Signal transduction by L1 | 1.584098e-01 | 0.800 |
R-HSA-8939211 | ESR-mediated signaling | 1.026129e-01 | 0.989 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.756627e-01 | 0.755 |
R-HSA-446652 | Interleukin-1 family signaling | 1.135226e-01 | 0.945 |
R-HSA-9734767 | Developmental Cell Lineages | 1.324538e-01 | 0.878 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.124534e-01 | 0.949 |
R-HSA-73887 | Death Receptor Signaling | 1.164647e-01 | 0.934 |
R-HSA-913531 | Interferon Signaling | 1.475582e-01 | 0.831 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 1.399219e-01 | 0.854 |
R-HSA-381070 | IRE1alpha activates chaperones | 1.541533e-01 | 0.812 |
R-HSA-72306 | tRNA processing | 1.425774e-01 | 0.846 |
R-HSA-5619102 | SLC transporter disorders | 1.362641e-01 | 0.866 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.164647e-01 | 0.934 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.032736e-01 | 0.692 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.036421e-01 | 0.691 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.036421e-01 | 0.691 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.036421e-01 | 0.691 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.036421e-01 | 0.691 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.036421e-01 | 0.691 |
R-HSA-264876 | Insulin processing | 2.036421e-01 | 0.691 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.091240e-01 | 0.680 |
R-HSA-113418 | Formation of the Early Elongation Complex | 2.091240e-01 | 0.680 |
R-HSA-167287 | HIV elongation arrest and recovery | 2.091240e-01 | 0.680 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 2.091240e-01 | 0.680 |
R-HSA-212165 | Epigenetic regulation of gene expression | 2.124237e-01 | 0.673 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.145684e-01 | 0.668 |
R-HSA-72086 | mRNA Capping | 2.145684e-01 | 0.668 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.156763e-01 | 0.666 |
R-HSA-69278 | Cell Cycle, Mitotic | 2.192980e-01 | 0.659 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 2.230634e-01 | 0.652 |
R-HSA-4791275 | Signaling by WNT in cancer | 2.306800e-01 | 0.637 |
R-HSA-8951664 | Neddylation | 2.319048e-01 | 0.635 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.359774e-01 | 0.627 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.359774e-01 | 0.627 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.359774e-01 | 0.627 |
R-HSA-5693537 | Resolution of D-Loop Structures | 2.412387e-01 | 0.618 |
R-HSA-5696400 | Dual Incision in GG-NER | 2.464640e-01 | 0.608 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.464640e-01 | 0.608 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.464640e-01 | 0.608 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 2.464640e-01 | 0.608 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.464640e-01 | 0.608 |
R-HSA-5205647 | Mitophagy | 2.464640e-01 | 0.608 |
R-HSA-9694516 | SARS-CoV-2 Infection | 2.506172e-01 | 0.601 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.516537e-01 | 0.599 |
R-HSA-212300 | PRC2 methylates histones and DNA | 2.568080e-01 | 0.590 |
R-HSA-9682385 | FLT3 signaling in disease | 2.568080e-01 | 0.590 |
R-HSA-3371511 | HSF1 activation | 2.568080e-01 | 0.590 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.670112e-01 | 0.573 |
R-HSA-73894 | DNA Repair | 2.672133e-01 | 0.573 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 2.717760e-01 | 0.566 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.720606e-01 | 0.565 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.770756e-01 | 0.557 |
R-HSA-167169 | HIV Transcription Elongation | 2.770756e-01 | 0.557 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.770756e-01 | 0.557 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.770756e-01 | 0.557 |
R-HSA-3371568 | Attenuation phase | 2.770756e-01 | 0.557 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 2.770756e-01 | 0.557 |
R-HSA-5619115 | Disorders of transmembrane transporters | 2.798703e-01 | 0.553 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.820563e-01 | 0.550 |
R-HSA-9609646 | HCMV Infection | 2.854774e-01 | 0.544 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.870030e-01 | 0.542 |
R-HSA-167161 | HIV Transcription Initiation | 2.870030e-01 | 0.542 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.870030e-01 | 0.542 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.870030e-01 | 0.542 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 2.920595e-01 | 0.535 |
R-HSA-5688426 | Deubiquitination | 2.948437e-01 | 0.530 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.967953e-01 | 0.528 |
R-HSA-8854214 | TBC/RABGAPs | 2.967953e-01 | 0.528 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.967953e-01 | 0.528 |
R-HSA-69620 | Cell Cycle Checkpoints | 3.004740e-01 | 0.522 |
R-HSA-3928662 | EPHB-mediated forward signaling | 3.016414e-01 | 0.521 |
R-HSA-375280 | Amine ligand-binding receptors | 3.016414e-01 | 0.521 |
R-HSA-5683826 | Surfactant metabolism | 3.016414e-01 | 0.521 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 3.047545e-01 | 0.516 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3.064543e-01 | 0.514 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.064543e-01 | 0.514 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.064543e-01 | 0.514 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.112344e-01 | 0.507 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.112344e-01 | 0.507 |
R-HSA-9675135 | Diseases of DNA repair | 3.112344e-01 | 0.507 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 3.112344e-01 | 0.507 |
R-HSA-392499 | Metabolism of proteins | 3.128033e-01 | 0.505 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.159819e-01 | 0.500 |
R-HSA-5620924 | Intraflagellar transport | 3.206969e-01 | 0.494 |
R-HSA-3371571 | HSF1-dependent transactivation | 3.346495e-01 | 0.475 |
R-HSA-912446 | Meiotic recombination | 3.346495e-01 | 0.475 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.392369e-01 | 0.469 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.437931e-01 | 0.464 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.437931e-01 | 0.464 |
R-HSA-877300 | Interferon gamma signaling | 3.450552e-01 | 0.462 |
R-HSA-5653656 | Vesicle-mediated transport | 3.466707e-01 | 0.460 |
R-HSA-418597 | G alpha (z) signalling events | 3.528121e-01 | 0.452 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.572755e-01 | 0.447 |
R-HSA-193648 | NRAGE signals death through JNK | 3.572755e-01 | 0.447 |
R-HSA-5621480 | Dectin-2 family | 3.617083e-01 | 0.442 |
R-HSA-6782135 | Dual incision in TC-NER | 3.661108e-01 | 0.436 |
R-HSA-180786 | Extension of Telomeres | 3.704833e-01 | 0.431 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.772556e-01 | 0.423 |
R-HSA-450294 | MAP kinase activation | 3.791387e-01 | 0.421 |
R-HSA-9793380 | Formation of paraxial mesoderm | 3.791387e-01 | 0.421 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 3.834221e-01 | 0.416 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.834221e-01 | 0.416 |
R-HSA-186797 | Signaling by PDGF | 3.834221e-01 | 0.416 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.876762e-01 | 0.412 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.876762e-01 | 0.412 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.919012e-01 | 0.407 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.960973e-01 | 0.402 |
R-HSA-8854518 | AURKA Activation by TPX2 | 4.002647e-01 | 0.398 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.002647e-01 | 0.398 |
R-HSA-212436 | Generic Transcription Pathway | 4.008897e-01 | 0.397 |
R-HSA-73857 | RNA Polymerase II Transcription | 4.023510e-01 | 0.395 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.044036e-01 | 0.393 |
R-HSA-913709 | O-linked glycosylation of mucins | 4.085143e-01 | 0.389 |
R-HSA-167172 | Transcription of the HIV genome | 4.085143e-01 | 0.389 |
R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 4.085143e-01 | 0.389 |
R-HSA-69275 | G2/M Transition | 4.135873e-01 | 0.383 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 4.164682e-01 | 0.380 |
R-HSA-204005 | COPII-mediated vesicle transport | 4.166513e-01 | 0.380 |
R-HSA-448424 | Interleukin-17 signaling | 4.166513e-01 | 0.380 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.166513e-01 | 0.380 |
R-HSA-453274 | Mitotic G2-G2/M phases | 4.183550e-01 | 0.378 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.206781e-01 | 0.376 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.206781e-01 | 0.376 |
R-HSA-112315 | Transmission across Chemical Synapses | 4.219750e-01 | 0.375 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.246774e-01 | 0.372 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.278323e-01 | 0.369 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.286493e-01 | 0.368 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.286493e-01 | 0.368 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.286493e-01 | 0.368 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.318662e-01 | 0.365 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 4.325411e-01 | 0.364 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.325941e-01 | 0.364 |
R-HSA-69473 | G2/M DNA damage checkpoint | 4.325941e-01 | 0.364 |
R-HSA-380287 | Centrosome maturation | 4.365118e-01 | 0.360 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.365118e-01 | 0.360 |
R-HSA-5689603 | UCH proteinases | 4.404028e-01 | 0.356 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.465441e-01 | 0.350 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.481050e-01 | 0.349 |
R-HSA-416482 | G alpha (12/13) signalling events | 4.481050e-01 | 0.349 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.557021e-01 | 0.341 |
R-HSA-72172 | mRNA Splicing | 4.580673e-01 | 0.339 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 4.594617e-01 | 0.338 |
R-HSA-449147 | Signaling by Interleukins | 4.607067e-01 | 0.337 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.705868e-01 | 0.327 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.705868e-01 | 0.327 |
R-HSA-6802957 | Oncogenic MAPK signaling | 4.742445e-01 | 0.324 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.778772e-01 | 0.321 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.814849e-01 | 0.317 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.886265e-01 | 0.311 |
R-HSA-9663891 | Selective autophagy | 4.886265e-01 | 0.311 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.956707e-01 | 0.305 |
R-HSA-2682334 | EPH-Ephrin signaling | 5.060569e-01 | 0.296 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.070868e-01 | 0.295 |
R-HSA-1474290 | Collagen formation | 5.128631e-01 | 0.290 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.195763e-01 | 0.284 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.228984e-01 | 0.282 |
R-HSA-157579 | Telomere Maintenance | 5.261978e-01 | 0.279 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.261978e-01 | 0.279 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.294745e-01 | 0.276 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.294745e-01 | 0.276 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.294745e-01 | 0.276 |
R-HSA-422356 | Regulation of insulin secretion | 5.294745e-01 | 0.276 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.327288e-01 | 0.273 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 5.327288e-01 | 0.273 |
R-HSA-9020702 | Interleukin-1 signaling | 5.391706e-01 | 0.268 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.486687e-01 | 0.261 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.548927e-01 | 0.256 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.640695e-01 | 0.249 |
R-HSA-9679506 | SARS-CoV Infections | 5.642172e-01 | 0.249 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.670866e-01 | 0.246 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.700830e-01 | 0.244 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 5.700830e-01 | 0.244 |
R-HSA-194068 | Bile acid and bile salt metabolism | 5.700830e-01 | 0.244 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.789494e-01 | 0.237 |
R-HSA-2262752 | Cellular responses to stress | 5.797909e-01 | 0.237 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.818645e-01 | 0.235 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.876346e-01 | 0.231 |
R-HSA-373760 | L1CAM interactions | 5.933259e-01 | 0.227 |
R-HSA-9007101 | Rab regulation of trafficking | 5.961422e-01 | 0.225 |
R-HSA-2980736 | Peptide hormone metabolism | 5.961422e-01 | 0.225 |
R-HSA-5693538 | Homology Directed Repair | 5.989393e-01 | 0.223 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.017171e-01 | 0.221 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.017171e-01 | 0.221 |
R-HSA-73886 | Chromosome Maintenance | 6.072157e-01 | 0.217 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.099367e-01 | 0.215 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.099367e-01 | 0.215 |
R-HSA-2132295 | MHC class II antigen presentation | 6.126390e-01 | 0.213 |
R-HSA-69481 | G2/M Checkpoints | 6.258749e-01 | 0.204 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.406595e-01 | 0.193 |
R-HSA-9909396 | Circadian clock | 6.411675e-01 | 0.193 |
R-HSA-1474228 | Degradation of the extracellular matrix | 6.411675e-01 | 0.193 |
R-HSA-163685 | Integration of energy metabolism | 6.534369e-01 | 0.185 |
R-HSA-5173105 | O-linked glycosylation | 6.558404e-01 | 0.183 |
R-HSA-9948299 | Ribosome-associated quality control | 6.582274e-01 | 0.182 |
R-HSA-112316 | Neuronal System | 6.587082e-01 | 0.181 |
R-HSA-1632852 | Macroautophagy | 6.652905e-01 | 0.177 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 6.744832e-01 | 0.171 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 6.812132e-01 | 0.167 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.834258e-01 | 0.165 |
R-HSA-69242 | S Phase | 6.834258e-01 | 0.165 |
R-HSA-9856651 | MITF-M-dependent gene expression | 6.878053e-01 | 0.163 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.899725e-01 | 0.161 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 6.942623e-01 | 0.158 |
R-HSA-69306 | DNA Replication | 6.942623e-01 | 0.158 |
R-HSA-1474244 | Extracellular matrix organization | 6.991404e-01 | 0.155 |
R-HSA-8953897 | Cellular responses to stimuli | 7.004608e-01 | 0.155 |
R-HSA-9612973 | Autophagy | 7.005869e-01 | 0.155 |
R-HSA-8953854 | Metabolism of RNA | 7.085882e-01 | 0.150 |
R-HSA-9006936 | Signaling by TGFB family members | 7.088184e-01 | 0.149 |
R-HSA-5633007 | Regulation of TP53 Activity | 7.088184e-01 | 0.149 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.340528e-01 | 0.134 |
R-HSA-5689880 | Ub-specific processing proteases | 7.359016e-01 | 0.133 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.359016e-01 | 0.133 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.359016e-01 | 0.133 |
R-HSA-422475 | Axon guidance | 7.523273e-01 | 0.124 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 7.537033e-01 | 0.123 |
R-HSA-3781865 | Diseases of glycosylation | 7.554167e-01 | 0.122 |
R-HSA-168898 | Toll-like Receptor Cascades | 7.670842e-01 | 0.115 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.702113e-01 | 0.113 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.750787e-01 | 0.111 |
R-HSA-389948 | Co-inhibition by PD-1 | 7.812780e-01 | 0.107 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.843138e-01 | 0.106 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.858161e-01 | 0.105 |
R-HSA-376176 | Signaling by ROBO receptors | 7.858161e-01 | 0.105 |
R-HSA-9675108 | Nervous system development | 7.894941e-01 | 0.103 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.016716e-01 | 0.096 |
R-HSA-418990 | Adherens junctions interactions | 8.084887e-01 | 0.092 |
R-HSA-1266738 | Developmental Biology | 8.109641e-01 | 0.091 |
R-HSA-421270 | Cell-cell junction organization | 8.480091e-01 | 0.072 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.532457e-01 | 0.069 |
R-HSA-9711123 | Cellular response to chemical stress | 8.650954e-01 | 0.063 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 8.706596e-01 | 0.060 |
R-HSA-446728 | Cell junction organization | 8.742420e-01 | 0.058 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.777261e-01 | 0.057 |
R-HSA-195721 | Signaling by WNT | 8.907315e-01 | 0.050 |
R-HSA-1500931 | Cell-Cell communication | 9.037297e-01 | 0.044 |
R-HSA-9824446 | Viral Infection Pathways | 9.037537e-01 | 0.044 |
R-HSA-8957322 | Metabolism of steroids | 9.090031e-01 | 0.041 |
R-HSA-168256 | Immune System | 9.303152e-01 | 0.031 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.448751e-01 | 0.025 |
R-HSA-418594 | G alpha (i) signalling events | 9.497213e-01 | 0.022 |
R-HSA-446203 | Asparagine N-linked glycosylation | 9.547904e-01 | 0.020 |
R-HSA-5668914 | Diseases of metabolism | 9.563648e-01 | 0.019 |
R-HSA-72766 | Translation | 9.569793e-01 | 0.019 |
R-HSA-388396 | GPCR downstream signalling | 9.754790e-01 | 0.011 |
R-HSA-1280218 | Adaptive Immune System | 9.803687e-01 | 0.009 |
R-HSA-372790 | Signaling by GPCR | 9.853274e-01 | 0.006 |
R-HSA-500792 | GPCR ligand binding | 9.862473e-01 | 0.006 |
R-HSA-5663205 | Infectious disease | 9.936161e-01 | 0.003 |
R-HSA-109582 | Hemostasis | 9.966287e-01 | 0.001 |
R-HSA-168249 | Innate Immune System | 9.993292e-01 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 9.999819e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
BMPR1B |
0.763 | 0.348 | 1 | 0.644 |
GRK1 |
0.760 | 0.279 | -2 | 0.755 |
COT |
0.759 | 0.197 | 2 | 0.745 |
CDC7 |
0.756 | 0.156 | 1 | 0.507 |
MOS |
0.756 | 0.271 | 1 | 0.441 |
KIS |
0.748 | 0.056 | 1 | 0.257 |
CLK3 |
0.746 | 0.075 | 1 | 0.352 |
BMPR1A |
0.743 | 0.253 | 1 | 0.622 |
TGFBR1 |
0.739 | 0.193 | -2 | 0.649 |
DSTYK |
0.739 | 0.056 | 2 | 0.765 |
GRK7 |
0.738 | 0.161 | 1 | 0.436 |
CK2A2 |
0.738 | 0.197 | 1 | 0.590 |
ACVR2B |
0.738 | 0.251 | -2 | 0.629 |
IKKB |
0.737 | -0.035 | -2 | 0.612 |
GRK2 |
0.737 | 0.254 | -2 | 0.625 |
PRPK |
0.735 | -0.021 | -1 | 0.630 |
MTOR |
0.735 | -0.053 | 1 | 0.308 |
GRK6 |
0.734 | 0.152 | 1 | 0.507 |
ACVR2A |
0.734 | 0.218 | -2 | 0.613 |
CDK1 |
0.734 | 0.043 | 1 | 0.304 |
RAF1 |
0.734 | -0.004 | 1 | 0.396 |
GCN2 |
0.732 | -0.088 | 2 | 0.656 |
GRK3 |
0.732 | 0.220 | -2 | 0.611 |
SKMLCK |
0.732 | 0.074 | -2 | 0.723 |
CK2A1 |
0.732 | 0.209 | 1 | 0.607 |
GRK5 |
0.731 | 0.058 | -3 | 0.810 |
PIM3 |
0.731 | -0.009 | -3 | 0.714 |
IKKA |
0.731 | -0.009 | -2 | 0.603 |
DRAK1 |
0.730 | 0.293 | 1 | 0.604 |
IKKE |
0.728 | -0.115 | 1 | 0.296 |
CAMK2G |
0.728 | -0.001 | 2 | 0.703 |
NLK |
0.728 | -0.031 | 1 | 0.347 |
TBK1 |
0.727 | -0.136 | 1 | 0.292 |
ERK5 |
0.727 | -0.052 | 1 | 0.331 |
NDR2 |
0.727 | -0.029 | -3 | 0.717 |
ALK4 |
0.727 | 0.135 | -2 | 0.676 |
BMPR2 |
0.727 | -0.045 | -2 | 0.704 |
ATR |
0.726 | -0.062 | 1 | 0.333 |
GRK4 |
0.726 | 0.044 | -2 | 0.728 |
ALK2 |
0.725 | 0.142 | -2 | 0.670 |
TGFBR2 |
0.725 | -0.002 | -2 | 0.629 |
CDK3 |
0.724 | 0.046 | 1 | 0.251 |
PDHK4 |
0.724 | -0.185 | 1 | 0.361 |
PRKD1 |
0.723 | -0.022 | -3 | 0.697 |
HIPK4 |
0.723 | -0.041 | 1 | 0.296 |
CAMK1B |
0.723 | -0.016 | -3 | 0.755 |
JNK2 |
0.723 | 0.005 | 1 | 0.256 |
RIPK3 |
0.722 | -0.022 | 3 | 0.617 |
MST4 |
0.722 | -0.027 | 2 | 0.697 |
CHAK2 |
0.721 | -0.051 | -1 | 0.560 |
DYRK2 |
0.721 | -0.027 | 1 | 0.281 |
MLK1 |
0.721 | -0.051 | 2 | 0.661 |
CK1E |
0.721 | 0.104 | -3 | 0.531 |
ULK2 |
0.721 | -0.151 | 2 | 0.620 |
DAPK2 |
0.720 | 0.040 | -3 | 0.768 |
CLK2 |
0.720 | 0.061 | -3 | 0.620 |
RSK2 |
0.720 | 0.004 | -3 | 0.637 |
HUNK |
0.720 | -0.002 | 2 | 0.690 |
NEK6 |
0.720 | -0.094 | -2 | 0.664 |
DLK |
0.720 | 0.069 | 1 | 0.430 |
FAM20C |
0.718 | -0.007 | 2 | 0.536 |
NEK7 |
0.718 | -0.113 | -3 | 0.825 |
JNK3 |
0.718 | -0.013 | 1 | 0.254 |
CDKL1 |
0.717 | -0.041 | -3 | 0.689 |
CDK8 |
0.717 | -0.064 | 1 | 0.257 |
PKN2 |
0.717 | -0.013 | -3 | 0.724 |
CDK2 |
0.717 | 0.047 | 1 | 0.356 |
ATM |
0.717 | -0.047 | 1 | 0.306 |
PLK1 |
0.716 | 0.078 | -2 | 0.604 |
PDHK1 |
0.716 | -0.228 | 1 | 0.333 |
P38B |
0.716 | -0.018 | 1 | 0.249 |
MARK4 |
0.716 | -0.062 | 4 | 0.881 |
WNK1 |
0.716 | -0.089 | -2 | 0.730 |
DYRK4 |
0.716 | 0.005 | 1 | 0.257 |
CAMLCK |
0.715 | -0.028 | -2 | 0.698 |
P38G |
0.715 | -0.025 | 1 | 0.241 |
CDK19 |
0.715 | -0.057 | 1 | 0.239 |
NUAK2 |
0.715 | -0.030 | -3 | 0.717 |
BCKDK |
0.715 | -0.140 | -1 | 0.542 |
CAMK2B |
0.715 | 0.020 | 2 | 0.697 |
PASK |
0.715 | 0.185 | -3 | 0.741 |
HIPK2 |
0.714 | -0.027 | 1 | 0.238 |
MAPKAPK2 |
0.714 | -0.012 | -3 | 0.568 |
ULK1 |
0.714 | -0.118 | -3 | 0.797 |
CAMK2A |
0.713 | 0.034 | 2 | 0.722 |
MLK3 |
0.713 | -0.025 | 2 | 0.589 |
CDK18 |
0.713 | -0.034 | 1 | 0.241 |
P90RSK |
0.713 | -0.032 | -3 | 0.652 |
CDK7 |
0.713 | -0.062 | 1 | 0.271 |
NIK |
0.712 | -0.102 | -3 | 0.787 |
PKN3 |
0.712 | -0.071 | -3 | 0.715 |
NDR1 |
0.712 | -0.081 | -3 | 0.705 |
CAMK2D |
0.712 | -0.068 | -3 | 0.722 |
MASTL |
0.712 | -0.125 | -2 | 0.662 |
SRPK1 |
0.712 | -0.046 | -3 | 0.633 |
PRKD2 |
0.712 | -0.044 | -3 | 0.620 |
CK1D |
0.711 | 0.094 | -3 | 0.483 |
CDK17 |
0.711 | -0.037 | 1 | 0.240 |
TSSK2 |
0.710 | -0.020 | -5 | 0.800 |
AURC |
0.710 | -0.010 | -2 | 0.545 |
P38D |
0.710 | -0.024 | 1 | 0.184 |
CDKL5 |
0.710 | -0.063 | -3 | 0.674 |
RSK4 |
0.710 | 0.021 | -3 | 0.603 |
CDK5 |
0.710 | -0.028 | 1 | 0.281 |
AURA |
0.710 | 0.017 | -2 | 0.529 |
TTBK2 |
0.709 | -0.099 | 2 | 0.542 |
YSK4 |
0.709 | -0.061 | 1 | 0.350 |
P38A |
0.709 | -0.040 | 1 | 0.272 |
ERK1 |
0.709 | -0.046 | 1 | 0.232 |
RIPK1 |
0.708 | -0.106 | 1 | 0.349 |
ICK |
0.708 | -0.066 | -3 | 0.722 |
CDK13 |
0.707 | -0.072 | 1 | 0.246 |
MAPKAPK3 |
0.707 | -0.071 | -3 | 0.630 |
RSK3 |
0.707 | -0.063 | -3 | 0.640 |
MEK1 |
0.707 | -0.006 | 2 | 0.707 |
PIM1 |
0.707 | -0.051 | -3 | 0.641 |
JNK1 |
0.707 | -0.003 | 1 | 0.266 |
MLK2 |
0.707 | -0.139 | 2 | 0.666 |
MSK1 |
0.706 | 0.006 | -3 | 0.613 |
AMPKA1 |
0.706 | -0.088 | -3 | 0.730 |
CLK4 |
0.706 | -0.015 | -3 | 0.641 |
MYLK4 |
0.706 | 0.027 | -2 | 0.642 |
PKACG |
0.706 | -0.070 | -2 | 0.600 |
CK1A2 |
0.706 | 0.080 | -3 | 0.477 |
MEKK3 |
0.706 | 0.043 | 1 | 0.392 |
PLK3 |
0.705 | -0.034 | 2 | 0.685 |
ANKRD3 |
0.705 | -0.108 | 1 | 0.378 |
MLK4 |
0.705 | -0.042 | 2 | 0.565 |
PRP4 |
0.705 | 0.018 | -3 | 0.786 |
MARK3 |
0.705 | -0.002 | 4 | 0.821 |
LATS1 |
0.704 | -0.013 | -3 | 0.740 |
NEK9 |
0.704 | -0.186 | 2 | 0.663 |
PKCD |
0.704 | -0.088 | 2 | 0.624 |
P70S6KB |
0.704 | -0.060 | -3 | 0.667 |
LATS2 |
0.704 | -0.089 | -5 | 0.616 |
HIPK1 |
0.703 | -0.043 | 1 | 0.282 |
DNAPK |
0.703 | -0.079 | 1 | 0.212 |
SMG1 |
0.702 | -0.104 | 1 | 0.276 |
MSK2 |
0.702 | -0.052 | -3 | 0.609 |
MST3 |
0.702 | 0.036 | 2 | 0.703 |
WNK3 |
0.702 | -0.237 | 1 | 0.313 |
PKR |
0.702 | -0.100 | 1 | 0.348 |
BRSK1 |
0.701 | -0.032 | -3 | 0.661 |
IRE1 |
0.701 | -0.141 | 1 | 0.306 |
TSSK1 |
0.701 | -0.074 | -3 | 0.753 |
CDK12 |
0.701 | -0.072 | 1 | 0.234 |
PAK1 |
0.701 | -0.080 | -2 | 0.657 |
QSK |
0.701 | -0.055 | 4 | 0.855 |
TLK2 |
0.699 | -0.124 | 1 | 0.314 |
PKCB |
0.699 | -0.069 | 2 | 0.580 |
CLK1 |
0.699 | -0.028 | -3 | 0.609 |
CAMK4 |
0.699 | -0.092 | -3 | 0.687 |
ERK2 |
0.699 | -0.067 | 1 | 0.245 |
PKACB |
0.698 | -0.026 | -2 | 0.542 |
MNK2 |
0.698 | -0.075 | -2 | 0.633 |
DYRK1B |
0.698 | -0.049 | 1 | 0.273 |
PKCG |
0.698 | -0.071 | 2 | 0.584 |
AMPKA2 |
0.698 | -0.097 | -3 | 0.686 |
NIM1 |
0.698 | -0.153 | 3 | 0.660 |
PRKX |
0.698 | -0.006 | -3 | 0.525 |
QIK |
0.697 | -0.098 | -3 | 0.724 |
PKCA |
0.697 | -0.079 | 2 | 0.569 |
CDK16 |
0.697 | -0.039 | 1 | 0.230 |
SRPK3 |
0.697 | -0.059 | -3 | 0.613 |
VRK2 |
0.697 | -0.218 | 1 | 0.355 |
SRPK2 |
0.696 | -0.066 | -3 | 0.543 |
GAK |
0.696 | 0.070 | 1 | 0.389 |
PRKD3 |
0.696 | -0.059 | -3 | 0.613 |
MARK2 |
0.696 | -0.037 | 4 | 0.789 |
AURB |
0.696 | -0.039 | -2 | 0.540 |
CK1G1 |
0.696 | -0.025 | -3 | 0.545 |
MPSK1 |
0.695 | -0.035 | 1 | 0.295 |
MARK1 |
0.695 | -0.024 | 4 | 0.846 |
CDK9 |
0.695 | -0.090 | 1 | 0.246 |
PAK3 |
0.695 | -0.125 | -2 | 0.646 |
GCK |
0.694 | 0.072 | 1 | 0.412 |
ZAK |
0.694 | -0.092 | 1 | 0.360 |
CDK14 |
0.694 | -0.048 | 1 | 0.264 |
TAO3 |
0.693 | -0.040 | 1 | 0.360 |
NEK11 |
0.693 | -0.009 | 1 | 0.367 |
MNK1 |
0.693 | -0.076 | -2 | 0.645 |
CHAK1 |
0.693 | -0.161 | 2 | 0.622 |
PKCZ |
0.692 | -0.118 | 2 | 0.613 |
PLK2 |
0.692 | 0.016 | -3 | 0.761 |
PAK2 |
0.692 | -0.105 | -2 | 0.644 |
BRAF |
0.692 | -0.076 | -4 | 0.776 |
CDK10 |
0.692 | -0.043 | 1 | 0.261 |
PLK4 |
0.692 | -0.133 | 2 | 0.504 |
MEK5 |
0.692 | -0.124 | 2 | 0.680 |
SIK |
0.691 | -0.092 | -3 | 0.625 |
DYRK1A |
0.691 | -0.071 | 1 | 0.271 |
BRSK2 |
0.691 | -0.106 | -3 | 0.685 |
HIPK3 |
0.691 | -0.079 | 1 | 0.252 |
NEK2 |
0.691 | -0.180 | 2 | 0.644 |
DYRK3 |
0.691 | -0.054 | 1 | 0.280 |
CK1A |
0.690 | 0.108 | -3 | 0.407 |
PAK6 |
0.690 | -0.070 | -2 | 0.588 |
PKCH |
0.690 | -0.098 | 2 | 0.560 |
PKG2 |
0.690 | -0.061 | -2 | 0.544 |
DAPK1 |
0.689 | 0.062 | -3 | 0.655 |
IRE2 |
0.689 | -0.175 | 2 | 0.579 |
PERK |
0.689 | -0.150 | -2 | 0.675 |
AKT2 |
0.689 | -0.046 | -3 | 0.550 |
TLK1 |
0.688 | -0.111 | -2 | 0.665 |
CAMK1G |
0.688 | -0.049 | -3 | 0.630 |
PHKG1 |
0.688 | -0.143 | -3 | 0.694 |
MEKK2 |
0.688 | -0.121 | 2 | 0.644 |
SMMLCK |
0.688 | -0.017 | -3 | 0.700 |
NUAK1 |
0.687 | -0.112 | -3 | 0.653 |
SGK3 |
0.687 | -0.084 | -3 | 0.625 |
MST2 |
0.686 | -0.021 | 1 | 0.385 |
MEKK1 |
0.686 | -0.180 | 1 | 0.326 |
HPK1 |
0.686 | 0.020 | 1 | 0.398 |
MELK |
0.686 | -0.138 | -3 | 0.671 |
GSK3A |
0.685 | -0.001 | 4 | 0.448 |
SNRK |
0.685 | -0.152 | 2 | 0.571 |
TAK1 |
0.684 | 0.014 | 1 | 0.362 |
PINK1 |
0.684 | -0.177 | 1 | 0.312 |
NEK5 |
0.684 | -0.172 | 1 | 0.318 |
DAPK3 |
0.684 | 0.003 | -3 | 0.669 |
TTBK1 |
0.684 | -0.125 | 2 | 0.480 |
CHK1 |
0.683 | -0.103 | -3 | 0.681 |
GSK3B |
0.683 | -0.006 | 4 | 0.439 |
HRI |
0.683 | -0.199 | -2 | 0.659 |
MAPKAPK5 |
0.682 | -0.136 | -3 | 0.591 |
PIM2 |
0.682 | -0.076 | -3 | 0.608 |
CAMKK1 |
0.681 | -0.120 | -2 | 0.617 |
WNK4 |
0.681 | -0.183 | -2 | 0.724 |
DCAMKL1 |
0.680 | -0.114 | -3 | 0.646 |
MINK |
0.680 | -0.064 | 1 | 0.340 |
LKB1 |
0.680 | -0.111 | -3 | 0.795 |
MAP3K15 |
0.679 | -0.103 | 1 | 0.320 |
CDK6 |
0.679 | -0.062 | 1 | 0.231 |
MAK |
0.678 | -0.034 | -2 | 0.649 |
NEK8 |
0.678 | -0.138 | 2 | 0.664 |
TXK |
0.678 | 0.317 | 1 | 0.574 |
PKACA |
0.678 | -0.049 | -2 | 0.500 |
ERK7 |
0.677 | -0.059 | 2 | 0.416 |
EEF2K |
0.677 | -0.056 | 3 | 0.745 |
IRAK4 |
0.676 | -0.200 | 1 | 0.288 |
PTK2 |
0.676 | 0.345 | -1 | 0.721 |
MEKK6 |
0.676 | -0.120 | 1 | 0.326 |
SSTK |
0.676 | -0.104 | 4 | 0.851 |
TAO2 |
0.676 | -0.127 | 2 | 0.685 |
BMPR2_TYR |
0.676 | 0.344 | -1 | 0.703 |
PKCT |
0.675 | -0.130 | 2 | 0.563 |
PKCE |
0.675 | -0.058 | 2 | 0.567 |
TNIK |
0.674 | -0.080 | 3 | 0.787 |
CAMKK2 |
0.674 | -0.147 | -2 | 0.611 |
PKCI |
0.673 | -0.107 | 2 | 0.574 |
DCAMKL2 |
0.673 | -0.106 | -3 | 0.674 |
BUB1 |
0.673 | 0.004 | -5 | 0.801 |
KHS2 |
0.672 | -0.035 | 1 | 0.358 |
P70S6K |
0.672 | -0.096 | -3 | 0.570 |
AKT1 |
0.672 | -0.078 | -3 | 0.562 |
CDK4 |
0.671 | -0.081 | 1 | 0.224 |
PDK1 |
0.671 | -0.153 | 1 | 0.308 |
SYK |
0.671 | 0.297 | -1 | 0.694 |
HGK |
0.671 | -0.130 | 3 | 0.763 |
MST1 |
0.671 | -0.084 | 1 | 0.355 |
KHS1 |
0.671 | -0.084 | 1 | 0.323 |
PAK5 |
0.671 | -0.102 | -2 | 0.531 |
IRAK1 |
0.670 | -0.210 | -1 | 0.487 |
CAMK1D |
0.670 | -0.072 | -3 | 0.528 |
NEK4 |
0.670 | -0.193 | 1 | 0.302 |
VRK1 |
0.670 | -0.127 | 2 | 0.683 |
PHKG2 |
0.669 | -0.156 | -3 | 0.668 |
PDHK3_TYR |
0.669 | 0.145 | 4 | 0.923 |
FYN |
0.667 | 0.217 | -1 | 0.706 |
PDHK4_TYR |
0.667 | 0.180 | 2 | 0.792 |
MOK |
0.667 | -0.072 | 1 | 0.281 |
STK33 |
0.667 | -0.122 | 2 | 0.503 |
PAK4 |
0.666 | -0.093 | -2 | 0.538 |
LRRK2 |
0.666 | -0.163 | 2 | 0.692 |
PBK |
0.666 | -0.098 | 1 | 0.306 |
MAP2K6_TYR |
0.666 | 0.187 | -1 | 0.646 |
NEK1 |
0.665 | -0.184 | 1 | 0.307 |
PDHK1_TYR |
0.665 | 0.185 | -1 | 0.662 |
OSR1 |
0.665 | -0.040 | 2 | 0.643 |
RIPK2 |
0.665 | -0.164 | 1 | 0.323 |
CHK2 |
0.664 | -0.053 | -3 | 0.483 |
ALPHAK3 |
0.664 | -0.010 | -1 | 0.575 |
EPHA6 |
0.664 | 0.157 | -1 | 0.672 |
YANK3 |
0.664 | -0.032 | 2 | 0.345 |
SLK |
0.664 | -0.109 | -2 | 0.555 |
MEK2 |
0.663 | -0.188 | 2 | 0.653 |
PKN1 |
0.662 | -0.105 | -3 | 0.584 |
ITK |
0.662 | 0.186 | -1 | 0.597 |
MAP2K4_TYR |
0.661 | 0.046 | -1 | 0.630 |
BMX |
0.661 | 0.156 | -1 | 0.569 |
SRMS |
0.661 | 0.170 | 1 | 0.491 |
YSK1 |
0.661 | -0.153 | 2 | 0.639 |
AKT3 |
0.660 | -0.067 | -3 | 0.476 |
EPHA4 |
0.660 | 0.130 | 2 | 0.713 |
SGK1 |
0.660 | -0.063 | -3 | 0.459 |
EPHB4 |
0.659 | 0.094 | -1 | 0.614 |
LOK |
0.659 | -0.172 | -2 | 0.594 |
ROCK2 |
0.658 | -0.092 | -3 | 0.650 |
TESK1_TYR |
0.658 | -0.008 | 3 | 0.771 |
TTK |
0.657 | -0.078 | -2 | 0.640 |
LCK |
0.657 | 0.114 | -1 | 0.683 |
MRCKA |
0.657 | -0.089 | -3 | 0.608 |
BLK |
0.656 | 0.106 | -1 | 0.668 |
HASPIN |
0.656 | -0.088 | -1 | 0.427 |
ASK1 |
0.655 | -0.130 | 1 | 0.314 |
PKMYT1_TYR |
0.655 | -0.059 | 3 | 0.745 |
FGR |
0.655 | 0.053 | 1 | 0.423 |
MRCKB |
0.654 | -0.097 | -3 | 0.597 |
CAMK1A |
0.654 | -0.078 | -3 | 0.500 |
PTK2B |
0.654 | 0.160 | -1 | 0.548 |
EPHB2 |
0.654 | 0.104 | -1 | 0.610 |
EPHB1 |
0.654 | 0.112 | 1 | 0.470 |
MAP2K7_TYR |
0.654 | -0.100 | 2 | 0.737 |
HCK |
0.653 | 0.076 | -1 | 0.657 |
BIKE |
0.653 | -0.069 | 1 | 0.304 |
FER |
0.652 | 0.035 | 1 | 0.441 |
DMPK1 |
0.652 | -0.053 | -3 | 0.614 |
MYO3B |
0.651 | -0.118 | 2 | 0.658 |
SBK |
0.651 | -0.075 | -3 | 0.412 |
YES1 |
0.650 | 0.013 | -1 | 0.618 |
MET |
0.650 | 0.068 | 3 | 0.672 |
ABL2 |
0.649 | -0.019 | -1 | 0.574 |
INSRR |
0.649 | 0.057 | 3 | 0.623 |
JAK3 |
0.649 | -0.001 | 1 | 0.316 |
SRC |
0.648 | 0.097 | -1 | 0.652 |
MYO3A |
0.648 | -0.114 | 1 | 0.317 |
CK1G2 |
0.648 | 0.073 | -3 | 0.460 |
CSF1R |
0.648 | -0.047 | 3 | 0.681 |
EPHB3 |
0.648 | 0.042 | -1 | 0.604 |
KIT |
0.648 | 0.003 | 3 | 0.682 |
PINK1_TYR |
0.648 | -0.102 | 1 | 0.370 |
EPHA7 |
0.647 | 0.083 | 2 | 0.690 |
ERBB4 |
0.646 | 0.119 | 1 | 0.399 |
ZAP70 |
0.646 | 0.123 | -1 | 0.638 |
EPHA8 |
0.646 | 0.110 | -1 | 0.638 |
ABL1 |
0.645 | -0.042 | -1 | 0.564 |
TEC |
0.645 | 0.055 | -1 | 0.514 |
MERTK |
0.645 | 0.029 | 3 | 0.657 |
MST1R |
0.644 | -0.105 | 3 | 0.703 |
TYRO3 |
0.644 | -0.082 | 3 | 0.690 |
NEK3 |
0.644 | -0.241 | 1 | 0.255 |
TAO1 |
0.644 | -0.158 | 1 | 0.276 |
RET |
0.643 | -0.170 | 1 | 0.307 |
FRK |
0.642 | 0.040 | -1 | 0.633 |
EPHA2 |
0.642 | 0.122 | -1 | 0.622 |
ROS1 |
0.642 | -0.115 | 3 | 0.658 |
PKG1 |
0.642 | -0.115 | -2 | 0.471 |
EPHA5 |
0.642 | 0.080 | 2 | 0.701 |
EGFR |
0.642 | 0.016 | 1 | 0.325 |
FLT1 |
0.642 | 0.043 | -1 | 0.640 |
ROCK1 |
0.642 | -0.103 | -3 | 0.610 |
EPHA3 |
0.641 | 0.042 | 2 | 0.673 |
LYN |
0.641 | 0.040 | 3 | 0.611 |
AAK1 |
0.641 | -0.052 | 1 | 0.245 |
STLK3 |
0.641 | -0.144 | 1 | 0.332 |
LIMK2_TYR |
0.641 | -0.148 | -3 | 0.804 |
ERBB2 |
0.641 | 0.007 | 1 | 0.354 |
CK1G3 |
0.640 | -0.012 | -3 | 0.368 |
CRIK |
0.640 | -0.085 | -3 | 0.549 |
JAK2 |
0.639 | -0.188 | 1 | 0.284 |
LIMK1_TYR |
0.638 | -0.189 | 2 | 0.693 |
TYK2 |
0.637 | -0.246 | 1 | 0.289 |
WEE1_TYR |
0.636 | -0.035 | -1 | 0.534 |
FGFR2 |
0.636 | -0.089 | 3 | 0.666 |
NTRK3 |
0.635 | -0.033 | -1 | 0.570 |
YANK2 |
0.635 | -0.040 | 2 | 0.352 |
DDR1 |
0.635 | -0.148 | 4 | 0.863 |
KDR |
0.635 | -0.066 | 3 | 0.636 |
BTK |
0.635 | -0.059 | -1 | 0.539 |
JAK1 |
0.634 | -0.127 | 1 | 0.270 |
INSR |
0.634 | -0.040 | 3 | 0.614 |
FGFR3 |
0.634 | -0.035 | 3 | 0.642 |
TNK2 |
0.633 | -0.107 | 3 | 0.647 |
NTRK1 |
0.633 | -0.065 | -1 | 0.588 |
MATK |
0.633 | -0.024 | -1 | 0.516 |
TEK |
0.632 | -0.079 | 3 | 0.629 |
FLT3 |
0.632 | -0.132 | 3 | 0.683 |
FES |
0.631 | 0.089 | -1 | 0.542 |
CSK |
0.631 | -0.043 | 2 | 0.685 |
AXL |
0.631 | -0.102 | 3 | 0.653 |
FGFR4 |
0.631 | -0.032 | -1 | 0.564 |
EPHA1 |
0.630 | -0.049 | 3 | 0.647 |
PDGFRB |
0.630 | -0.158 | 3 | 0.684 |
ALK |
0.629 | -0.096 | 3 | 0.598 |
IGF1R |
0.628 | 0.008 | 3 | 0.561 |
FGFR1 |
0.627 | -0.161 | 3 | 0.641 |
LTK |
0.626 | -0.124 | 3 | 0.625 |
PTK6 |
0.626 | -0.158 | -1 | 0.511 |
NTRK2 |
0.625 | -0.122 | 3 | 0.639 |
NEK10_TYR |
0.625 | -0.190 | 1 | 0.220 |
TNNI3K_TYR |
0.623 | -0.173 | 1 | 0.289 |
FLT4 |
0.623 | -0.106 | 3 | 0.634 |
DDR2 |
0.619 | -0.089 | 3 | 0.607 |
PDGFRA |
0.619 | -0.227 | 3 | 0.692 |
MUSK |
0.617 | -0.086 | 1 | 0.312 |
TNK1 |
0.617 | -0.229 | 3 | 0.672 |