Motif 431 (n=93)

Position-wise Probabilities

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uniprot genes site source protein function
A6NKT7 RGPD3 S1264 ochoa RanBP2-like and GRIP domain-containing protein 3 None
E9PCH4 None S778 ochoa Rap guanine nucleotide exchange factor 6 None
O14715 RGPD8 S1263 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O15049 N4BP3 S209 ochoa NEDD4-binding protein 3 (N4BP3) Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}.
O15049 N4BP3 S210 ochoa NEDD4-binding protein 3 (N4BP3) Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}.
O15231 ZNF185 S132 ochoa Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) May be involved in the regulation of cellular proliferation and/or differentiation.
O15265 ATXN7 S217 ochoa Ataxin-7 (Spinocerebellar ataxia type 7 protein) Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}.
O43314 PPIP5K2 S1221 ochoa Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}.
O60238 BNIP3L S62 ochoa BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
O60861 GAS7 S162 ochoa Growth arrest-specific protein 7 (GAS-7) May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
O75385 ULK1 S224 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75581 LRP6 S1474 ochoa Low-density lipoprotein receptor-related protein 6 (LRP-6) Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}.
O75808 CAPN15 S337 ochoa Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) None
O94979 SEC31A S351 ochoa Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}.
P05549 TFAP2A S223 ochoa Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}.
P08913 ADRA2A S313 psp Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}.
P11362 FGFR1 S452 ochoa Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.
P13489 RNH1 S255 ochoa Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}.
P21802 FGFR2 S452 ochoa Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.
P35269 GTF2F1 S398 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P39880 CUX1 S875 ochoa Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
P49790 NUP153 S938 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P49792 RANBP2 S2239 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50454 SERPINH1 S139 ochoa Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
P51116 FXR2 S446 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P53814 SMTN S713 ochoa Smoothelin Structural protein of the cytoskeleton.
P54132 BLM S1379 ochoa RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}.
Q03164 KMT2A S2316 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q05209 PTPN12 S555 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q08AD1 CAMSAP2 S692 ochoa Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.
Q15018 ABRAXAS2 S339 ochoa BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}.
Q15303 ERBB4 S1124 ochoa Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}.
Q15643 TRIP11 S1858 ochoa Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.
Q16531 DDB1 S661 ochoa DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMed:16482215, PubMed:16940174, PubMed:17079684). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:38316879}.
Q16649 NFIL3 S285 ochoa Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}.
Q16658 FSCN1 S120 ochoa Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}.
Q5JTV8 TOR1AIP1 S263 ochoa Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.
Q5SRE5 NUP188 S1530 ochoa Nucleoporin NUP188 (hNup188) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}.
Q5TAQ9 DCAF8 S20 ochoa DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.
Q6QNK2 ADGRD1 S829 ochoa Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)] Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271). {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:35447113, ECO:0000269|PubMed:39884271}.
Q6T4R5 NHS S1479 ochoa Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.
Q6UX73 C16orf89 S173 ochoa UPF0764 protein C16orf89 None
Q6VUC0 TFAP2E S230 ochoa Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}.
Q6ZN18 AEBP2 S146 ochoa Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Q6ZN18 AEBP2 S147 ochoa Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Q6ZU67 BEND4 S99 ochoa BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4) None
Q7Z2Z1 TICRR S1718 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z3J3 RGPD4 S1264 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z460 CLASP1 S253 ochoa CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.
Q7Z589 EMSY S211 ochoa BRCA2-interacting transcriptional repressor EMSY Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.
Q7Z6R9 TFAP2D S223 ochoa Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}.
Q86XJ1 GAS2L3 S621 ochoa GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}.
Q8N1W1 ARHGEF28 S477 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N5C8 TAB3 S356 ochoa TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}.
Q8NEY1 NAV1 S697 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8TAT6 NPLOC4 S59 ochoa Nuclear protein localization protein 4 homolog (Protein NPL4) The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}.
Q8TEU7 RAPGEF6 S728 ochoa Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.
Q8WVM7 STAG1 S1069 ochoa Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Q8WXI7 MUC16 S9554 ochoa Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
Q92481 TFAP2B S242 ochoa Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}.
Q92754 TFAP2C S236 ochoa Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}.
Q96EZ8 MCRS1 S91 ochoa Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}.
Q96HI0 SENP5 S423 ochoa Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}.
Q96NE9 FRMD6 S390 ochoa FERM domain-containing protein 6 (Willin) None
Q96NE9 FRMD6 S413 ochoa FERM domain-containing protein 6 (Willin) None
Q96P11 NSUN5 S166 ochoa 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}.
Q96PE2 ARHGEF17 S568 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q99501 GAS2L1 S601 ochoa GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q99666 RGPD5 S1263 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9BWT7 CARD10 S570 ochoa Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}.
Q9BZF3 OSBPL6 S45 ochoa Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}.
Q9C040 TRIM2 S102 ochoa Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}.
Q9C0D0 PHACTR1 S186 ochoa Phosphatase and actin regulator 1 Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}.
Q9H1B7 IRF2BPL S336 ochoa Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}.
Q9H201 EPN3 S190 ochoa Epsin-3 (EPS-15-interacting protein 3) None
Q9H201 EPN3 S505 ochoa Epsin-3 (EPS-15-interacting protein 3) None
Q9HCM3 KIAA1549 S1913 ochoa UPF0606 protein KIAA1549 May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}.
Q9NQW6 ANLN S140 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NR09 BIRC6 S462 ochoa Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}.
Q9NRR5 UBQLN4 S317 ochoa Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}.
Q9P227 ARHGAP23 S1350 ochoa Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9UH99 SUN2 S19 ochoa SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}.
Q9UHD8 SEPTIN9 S22 ochoa Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}.
Q9ULT8 HECTD1 S1531 ochoa E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}.
Q9UPN3 MACF1 S7235 ochoa Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UPS6 SETD1B S1767 ochoa Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}.
Q9UPT5 EXOC7 S243 ochoa Exocyst complex component 7 (Exocyst complex component Exo70) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:E7FC72}.
Q9UQ35 SRRM2 S819 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2D8 SSX2IP S31 ochoa Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}.
Q9Y2F5 ICE1 S1330 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y5X1 SNX9 S199 ochoa Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.
Q9Y6I3 EPN1 S419 ochoa Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}.
Q9Y6M4 CSNK1G3 S33 ochoa Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}.
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reactome_id name p -log10_p
R-HSA-1226099 Signaling by FGFR in disease 1.770917e-11 10.752
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.189966e-10 9.924
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 2.163454e-10 9.665
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 2.757850e-08 7.559
R-HSA-8851708 Signaling by FGFR2 IIIa TM 2.170397e-08 7.663
R-HSA-1839126 FGFR2 mutant receptor activation 2.579259e-08 7.589
R-HSA-5655253 Signaling by FGFR2 in disease 1.925162e-07 6.716
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 7.403049e-07 6.131
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 1.920862e-06 5.717
R-HSA-109704 PI3K Cascade 3.577119e-06 5.446
R-HSA-2219528 PI3K/AKT Signaling in Cancer 4.253645e-06 5.371
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 5.567021e-06 5.254
R-HSA-112399 IRS-mediated signalling 6.815919e-06 5.166
R-HSA-199418 Negative regulation of the PI3K/AKT network 8.377365e-06 5.077
R-HSA-2428928 IRS-related events triggered by IGF1R 9.538354e-06 5.021
R-HSA-190236 Signaling by FGFR 1.195917e-05 4.922
R-HSA-2428924 IGF1R signaling cascade 1.210951e-05 4.917
R-HSA-74751 Insulin receptor signalling cascade 1.210951e-05 4.917
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1.308138e-05 4.883
R-HSA-9834899 Specification of the neural plate border 2.601838e-05 4.585
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 3.047169e-05 4.516
R-HSA-190241 FGFR2 ligand binding and activation 3.545941e-05 4.450
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 4.719268e-05 4.326
R-HSA-1253288 Downregulation of ERBB4 signaling 6.690468e-05 4.175
R-HSA-5654695 PI-3K cascade:FGFR2 6.979094e-05 4.156
R-HSA-74752 Signaling by Insulin receptor 8.286108e-05 4.082
R-HSA-5654699 SHC-mediated cascade:FGFR2 8.867815e-05 4.052
R-HSA-5654700 FRS-mediated FGFR2 signaling 9.939887e-05 4.003
R-HSA-1250196 SHC1 events in ERBB2 signaling 1.236195e-04 3.908
R-HSA-1227990 Signaling by ERBB2 in Cancer 1.236195e-04 3.908
R-HSA-8863795 Downregulation of ERBB2 signaling 1.236195e-04 3.908
R-HSA-1839124 FGFR1 mutant receptor activation 1.675927e-04 3.776
R-HSA-5654727 Negative regulation of FGFR2 signaling 2.025570e-04 3.693
R-HSA-5654696 Downstream signaling of activated FGFR2 2.218796e-04 3.654
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 2.830533e-04 3.548
R-HSA-6785631 ERBB2 Regulates Cell Motility 3.312368e-04 3.480
R-HSA-5673001 RAF/MAP kinase cascade 3.068552e-04 3.513
R-HSA-1251985 Nuclear signaling by ERBB4 3.388904e-04 3.470
R-HSA-5684996 MAPK1/MAPK3 signaling 3.607654e-04 3.443
R-HSA-5654738 Signaling by FGFR2 3.863810e-04 3.413
R-HSA-5655302 Signaling by FGFR1 in disease 3.961633e-04 3.402
R-HSA-1250347 SHC1 events in ERBB4 signaling 4.427840e-04 3.354
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 4.427840e-04 3.354
R-HSA-1963640 GRB2 events in ERBB2 signaling 4.427840e-04 3.354
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 4.441119e-04 3.353
R-HSA-1839120 Signaling by FGFR1 amplification mutants 5.754741e-04 3.240
R-HSA-2023837 Signaling by FGFR2 amplification mutants 5.754741e-04 3.240
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors 5.754741e-04 3.240
R-HSA-2033519 Activated point mutants of FGFR2 5.759389e-04 3.240
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 8.249622e-04 3.084
R-HSA-5683057 MAPK family signaling cascades 1.038330e-03 2.984
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 1.234193e-03 2.909
R-HSA-168325 Viral Messenger RNA Synthesis 1.402173e-03 2.853
R-HSA-1227986 Signaling by ERBB2 1.329600e-03 2.876
R-HSA-9620244 Long-term potentiation 1.355000e-03 2.868
R-HSA-1257604 PIP3 activates AKT signaling 1.589934e-03 2.799
R-HSA-9664565 Signaling by ERBB2 KD Mutants 1.911634e-03 2.719
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.069885e-03 2.684
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.236057e-03 2.651
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.236057e-03 2.651
R-HSA-1855170 IPs transport between nucleus and cytosol 2.592694e-03 2.586
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.592694e-03 2.586
R-HSA-9924644 Developmental Lineages of the Mammary Gland 2.391739e-03 2.621
R-HSA-1236394 Signaling by ERBB4 2.612524e-03 2.583
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.783417e-03 2.555
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.783417e-03 2.555
R-HSA-180746 Nuclear import of Rev protein 2.982575e-03 2.525
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.190288e-03 2.496
R-HSA-1474165 Reproduction 3.548766e-03 2.450
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 3.190288e-03 2.496
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.631838e-03 2.440
R-HSA-9006925 Intracellular signaling by second messengers 3.712995e-03 2.430
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.865896e-03 2.413
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 4.108951e-03 2.386
R-HSA-168276 NS1 Mediated Effects on Host Pathways 4.108951e-03 2.386
R-HSA-1839122 Signaling by activated point mutants of FGFR1 4.951905e-03 2.305
R-HSA-1250342 PI3K events in ERBB4 signaling 4.951905e-03 2.305
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 4.361106e-03 2.360
R-HSA-190377 FGFR2b ligand binding and activation 4.333022e-03 2.363
R-HSA-177243 Interactions of Rev with host cellular proteins 4.361106e-03 2.360
R-HSA-176033 Interactions of Vpr with host cellular proteins 4.361106e-03 2.360
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4.622458e-03 2.335
R-HSA-3214841 PKMTs methylate histone lysines 4.622458e-03 2.335
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 6.070410e-03 2.217
R-HSA-9758941 Gastrulation 6.206031e-03 2.207
R-HSA-190375 FGFR2c ligand binding and activation 6.303777e-03 2.200
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 6.388839e-03 2.195
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 8.013905e-03 2.096
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 9.827645e-03 2.008
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 1.032403e-02 1.986
R-HSA-190242 FGFR1 ligand binding and activation 1.123370e-02 1.949
R-HSA-9827857 Specification of primordial germ cells 1.032403e-02 1.986
R-HSA-194441 Metabolism of non-coding RNA 1.144407e-02 1.941
R-HSA-191859 snRNP Assembly 1.144407e-02 1.941
R-HSA-1963642 PI3K events in ERBB2 signaling 1.032403e-02 1.986
R-HSA-1483249 Inositol phosphate metabolism 1.097463e-02 1.960
R-HSA-2980766 Nuclear Envelope Breakdown 1.055306e-02 1.977
R-HSA-6784531 tRNA processing in the nucleus 1.285973e-02 1.891
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 1.335287e-02 1.874
R-HSA-8848021 Signaling by PTK6 1.335287e-02 1.874
R-HSA-3371556 Cellular response to heat stress 1.456362e-02 1.837
R-HSA-5654689 PI-3K cascade:FGFR1 1.628230e-02 1.788
R-HSA-5578749 Transcriptional regulation by small RNAs 1.827504e-02 1.738
R-HSA-5654688 SHC-mediated cascade:FGFR1 1.852603e-02 1.732
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.887610e-02 1.724
R-HSA-5654693 FRS-mediated FGFR1 signaling 1.969405e-02 1.706
R-HSA-1169408 ISG15 antiviral mechanism 2.011090e-02 1.697
R-HSA-8853333 Signaling by FGFR2 fusions 2.046891e-02 1.689
R-HSA-9018519 Estrogen-dependent gene expression 2.189267e-02 1.660
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.212004e-02 1.655
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.477633e-02 1.606
R-HSA-5696394 DNA Damage Recognition in GG-NER 3.150825e-02 1.502
R-HSA-162599 Late Phase of HIV Life Cycle 2.525489e-02 1.598
R-HSA-1500620 Meiosis 2.693944e-02 1.570
R-HSA-182971 EGFR downregulation 2.731916e-02 1.564
R-HSA-5654726 Negative regulation of FGFR1 signaling 3.008516e-02 1.522
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.228643e-02 1.491
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 2.525489e-02 1.598
R-HSA-3247509 Chromatin modifying enzymes 3.174801e-02 1.498
R-HSA-9008059 Interleukin-37 signaling 2.597711e-02 1.585
R-HSA-438064 Post NMDA receptor activation events 2.920048e-02 1.535
R-HSA-162587 HIV Life Cycle 3.346027e-02 1.475
R-HSA-8853336 Signaling by plasma membrane FGFR1 fusions 3.388362e-02 1.470
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 3.388362e-02 1.470
R-HSA-5654687 Downstream signaling of activated FGFR1 3.443249e-02 1.463
R-HSA-4839726 Chromatin organization 3.906836e-02 1.408
R-HSA-70171 Glycolysis 4.195913e-02 1.377
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 4.384056e-02 1.358
R-HSA-6811438 Intra-Golgi traffic 4.544386e-02 1.343
R-HSA-190374 FGFR1c and Klotho ligand binding and activation 4.711625e-02 1.327
R-HSA-168255 Influenza Infection 4.874386e-02 1.312
R-HSA-9700206 Signaling by ALK in cancer 4.973352e-02 1.303
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.973352e-02 1.303
R-HSA-211000 Gene Silencing by RNA 4.973352e-02 1.303
R-HSA-5340588 Signaling by RNF43 mutants 5.366505e-02 1.270
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 5.366505e-02 1.270
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 5.658817e-02 1.247
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 6.016925e-02 1.221
R-HSA-2470946 Cohesin Loading onto Chromatin 6.662914e-02 1.176
R-HSA-190370 FGFR1b ligand binding and activation 7.304503e-02 1.136
R-HSA-9700645 ALK mutants bind TKIs 7.941721e-02 1.100
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 8.574598e-02 1.067
R-HSA-1221632 Meiotic synapsis 6.682154e-02 1.175
R-HSA-5654736 Signaling by FGFR1 7.259966e-02 1.139
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.721319e-02 1.173
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 8.574598e-02 1.067
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 7.941721e-02 1.100
R-HSA-8934903 Receptor Mediated Mitophagy 8.574598e-02 1.067
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 6.662914e-02 1.176
R-HSA-390696 Adrenoceptors 7.304503e-02 1.136
R-HSA-68882 Mitotic Anaphase 8.111220e-02 1.091
R-HSA-2555396 Mitotic Metaphase and Anaphase 8.207988e-02 1.086
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 8.574598e-02 1.067
R-HSA-177929 Signaling by EGFR 7.259966e-02 1.139
R-HSA-73893 DNA Damage Bypass 5.937423e-02 1.226
R-HSA-162909 Host Interactions of HIV factors 7.076531e-02 1.150
R-HSA-597592 Post-translational protein modification 6.885595e-02 1.162
R-HSA-1643685 Disease 7.724250e-02 1.112
R-HSA-68875 Mitotic Prophase 6.604792e-02 1.180
R-HSA-70326 Glucose metabolism 6.260915e-02 1.203
R-HSA-75893 TNF signaling 7.259966e-02 1.139
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 9.203163e-02 1.036
R-HSA-162906 HIV Infection 9.206933e-02 1.036
R-HSA-9705683 SARS-CoV-2-host interactions 9.309910e-02 1.031
R-HSA-162582 Signal Transduction 9.469836e-02 1.024
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 9.717877e-02 1.012
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 9.827445e-02 1.008
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 9.827445e-02 1.008
R-HSA-68884 Mitotic Telophase/Cytokinesis 9.827445e-02 1.008
R-HSA-5083636 Defective GALNT12 causes CRCS1 1.288562e-01 0.890
R-HSA-5083625 Defective GALNT3 causes HFTC 1.288562e-01 0.890
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 1.407990e-01 0.851
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1.525796e-01 0.817
R-HSA-9709603 Impaired BRCA2 binding to PALB2 1.525796e-01 0.817
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 1.584098e-01 0.800
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.584098e-01 0.800
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 1.584098e-01 0.800
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.584098e-01 0.800
R-HSA-6803529 FGFR2 alternative splicing 1.756627e-01 0.755
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 1.813354e-01 0.742
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 1.813354e-01 0.742
R-HSA-977068 Termination of O-glycan biosynthesis 1.813354e-01 0.742
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 1.925651e-01 0.715
R-HSA-141424 Amplification of signal from the kinetochores 1.375792e-01 0.861
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.375792e-01 0.861
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 1.981225e-01 0.703
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 1.399219e-01 0.854
R-HSA-5696398 Nucleotide Excision Repair 1.932882e-01 0.714
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 1.348480e-01 0.870
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 1.329210e-01 0.876
R-HSA-190373 FGFR1c ligand binding and activation 1.106328e-01 0.956
R-HSA-9703465 Signaling by FLT3 fusion proteins 1.981225e-01 0.703
R-HSA-69618 Mitotic Spindle Checkpoint 1.784428e-01 0.749
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 1.228232e-01 0.911
R-HSA-4641263 Regulation of FZD by ubiquitination 1.407990e-01 0.851
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 1.467095e-01 0.834
R-HSA-68877 Mitotic Prometaphase 1.806222e-01 0.743
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 1.167488e-01 0.933
R-HSA-2467813 Separation of Sister Chromatids 1.315951e-01 0.881
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 1.642001e-01 0.785
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 1.869695e-01 0.728
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 1.981225e-01 0.703
R-HSA-110320 Translesion Synthesis by POLH 1.525796e-01 0.817
R-HSA-5617833 Cilium Assembly 1.755073e-01 0.756
R-HSA-68886 M Phase 1.464931e-01 0.834
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 1.525796e-01 0.817
R-HSA-5620916 VxPx cargo-targeting to cilium 1.584098e-01 0.800
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 1.699510e-01 0.770
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 1.981225e-01 0.703
R-HSA-5689901 Metalloprotease DUBs 1.981225e-01 0.703
R-HSA-9609690 HCMV Early Events 1.857777e-01 0.731
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 1.164647e-01 0.934
R-HSA-199991 Membrane Trafficking 1.795306e-01 0.746
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 1.813354e-01 0.742
R-HSA-3214847 HATs acetylate histones 1.759864e-01 0.755
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1.044747e-01 0.981
R-HSA-74160 Gene expression (Transcription) 1.385536e-01 0.858
R-HSA-1640170 Cell Cycle 1.311340e-01 0.882
R-HSA-9610379 HCMV Late Events 1.209316e-01 0.917
R-HSA-445144 Signal transduction by L1 1.584098e-01 0.800
R-HSA-8939211 ESR-mediated signaling 1.026129e-01 0.989
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 1.756627e-01 0.755
R-HSA-446652 Interleukin-1 family signaling 1.135226e-01 0.945
R-HSA-9734767 Developmental Cell Lineages 1.324538e-01 0.878
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 1.124534e-01 0.949
R-HSA-73887 Death Receptor Signaling 1.164647e-01 0.934
R-HSA-913531 Interferon Signaling 1.475582e-01 0.831
R-HSA-381038 XBP1(S) activates chaperone genes 1.399219e-01 0.854
R-HSA-381070 IRE1alpha activates chaperones 1.541533e-01 0.812
R-HSA-72306 tRNA processing 1.425774e-01 0.846
R-HSA-5619102 SLC transporter disorders 1.362641e-01 0.866
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.164647e-01 0.934
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.032736e-01 0.692
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.036421e-01 0.691
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.036421e-01 0.691
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.036421e-01 0.691
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 2.036421e-01 0.691
R-HSA-174414 Processive synthesis on the C-strand of the telomere 2.036421e-01 0.691
R-HSA-264876 Insulin processing 2.036421e-01 0.691
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 2.091240e-01 0.680
R-HSA-113418 Formation of the Early Elongation Complex 2.091240e-01 0.680
R-HSA-167287 HIV elongation arrest and recovery 2.091240e-01 0.680
R-HSA-167290 Pausing and recovery of HIV elongation 2.091240e-01 0.680
R-HSA-212165 Epigenetic regulation of gene expression 2.124237e-01 0.673
R-HSA-9709570 Impaired BRCA2 binding to RAD51 2.145684e-01 0.668
R-HSA-72086 mRNA Capping 2.145684e-01 0.668
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 2.156763e-01 0.666
R-HSA-69278 Cell Cycle, Mitotic 2.192980e-01 0.659
R-HSA-1280215 Cytokine Signaling in Immune system 2.230634e-01 0.652
R-HSA-4791275 Signaling by WNT in cancer 2.306800e-01 0.637
R-HSA-8951664 Neddylation 2.319048e-01 0.635
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 2.359774e-01 0.627
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 2.359774e-01 0.627
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 2.359774e-01 0.627
R-HSA-5693537 Resolution of D-Loop Structures 2.412387e-01 0.618
R-HSA-5696400 Dual Incision in GG-NER 2.464640e-01 0.608
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 2.464640e-01 0.608
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 2.464640e-01 0.608
R-HSA-168638 NOD1/2 Signaling Pathway 2.464640e-01 0.608
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 2.464640e-01 0.608
R-HSA-5205647 Mitophagy 2.464640e-01 0.608
R-HSA-9694516 SARS-CoV-2 Infection 2.506172e-01 0.601
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 2.516537e-01 0.599
R-HSA-212300 PRC2 methylates histones and DNA 2.568080e-01 0.590
R-HSA-9682385 FLT3 signaling in disease 2.568080e-01 0.590
R-HSA-3371511 HSF1 activation 2.568080e-01 0.590
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 2.670112e-01 0.573
R-HSA-73894 DNA Repair 2.672133e-01 0.573
R-HSA-9006931 Signaling by Nuclear Receptors 2.717760e-01 0.566
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 2.720606e-01 0.565
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 2.770756e-01 0.557
R-HSA-167169 HIV Transcription Elongation 2.770756e-01 0.557
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 2.770756e-01 0.557
R-HSA-5696395 Formation of Incision Complex in GG-NER 2.770756e-01 0.557
R-HSA-3371568 Attenuation phase 2.770756e-01 0.557
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 2.770756e-01 0.557
R-HSA-5619115 Disorders of transmembrane transporters 2.798703e-01 0.553
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 2.820563e-01 0.550
R-HSA-9609646 HCMV Infection 2.854774e-01 0.544
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 2.870030e-01 0.542
R-HSA-167161 HIV Transcription Initiation 2.870030e-01 0.542
R-HSA-75953 RNA Polymerase II Transcription Initiation 2.870030e-01 0.542
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 2.870030e-01 0.542
R-HSA-381119 Unfolded Protein Response (UPR) 2.920595e-01 0.535
R-HSA-5688426 Deubiquitination 2.948437e-01 0.530
R-HSA-73776 RNA Polymerase II Promoter Escape 2.967953e-01 0.528
R-HSA-8854214 TBC/RABGAPs 2.967953e-01 0.528
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 2.967953e-01 0.528
R-HSA-69620 Cell Cycle Checkpoints 3.004740e-01 0.522
R-HSA-3928662 EPHB-mediated forward signaling 3.016414e-01 0.521
R-HSA-375280 Amine ligand-binding receptors 3.016414e-01 0.521
R-HSA-5683826 Surfactant metabolism 3.016414e-01 0.521
R-HSA-8856828 Clathrin-mediated endocytosis 3.047545e-01 0.516
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 3.064543e-01 0.514
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 3.064543e-01 0.514
R-HSA-76009 Platelet Aggregation (Plug Formation) 3.064543e-01 0.514
R-HSA-72165 mRNA Splicing - Minor Pathway 3.112344e-01 0.507
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 3.112344e-01 0.507
R-HSA-9675135 Diseases of DNA repair 3.112344e-01 0.507
R-HSA-5357905 Regulation of TNFR1 signaling 3.112344e-01 0.507
R-HSA-392499 Metabolism of proteins 3.128033e-01 0.505
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 3.159819e-01 0.500
R-HSA-5620924 Intraflagellar transport 3.206969e-01 0.494
R-HSA-3371571 HSF1-dependent transactivation 3.346495e-01 0.475
R-HSA-912446 Meiotic recombination 3.346495e-01 0.475
R-HSA-112382 Formation of RNA Pol II elongation complex 3.392369e-01 0.469
R-HSA-75955 RNA Polymerase II Transcription Elongation 3.437931e-01 0.464
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.437931e-01 0.464
R-HSA-877300 Interferon gamma signaling 3.450552e-01 0.462
R-HSA-5653656 Vesicle-mediated transport 3.466707e-01 0.460
R-HSA-418597 G alpha (z) signalling events 3.528121e-01 0.452
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 3.572755e-01 0.447
R-HSA-193648 NRAGE signals death through JNK 3.572755e-01 0.447
R-HSA-5621480 Dectin-2 family 3.617083e-01 0.442
R-HSA-6782135 Dual incision in TC-NER 3.661108e-01 0.436
R-HSA-180786 Extension of Telomeres 3.704833e-01 0.431
R-HSA-5621481 C-type lectin receptors (CLRs) 3.772556e-01 0.423
R-HSA-450294 MAP kinase activation 3.791387e-01 0.421
R-HSA-9793380 Formation of paraxial mesoderm 3.791387e-01 0.421
R-HSA-375165 NCAM signaling for neurite out-growth 3.834221e-01 0.416
R-HSA-9616222 Transcriptional regulation of granulopoiesis 3.834221e-01 0.416
R-HSA-186797 Signaling by PDGF 3.834221e-01 0.416
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 3.876762e-01 0.412
R-HSA-380259 Loss of Nlp from mitotic centrosomes 3.876762e-01 0.412
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 3.919012e-01 0.407
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 3.960973e-01 0.402
R-HSA-8854518 AURKA Activation by TPX2 4.002647e-01 0.398
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 4.002647e-01 0.398
R-HSA-212436 Generic Transcription Pathway 4.008897e-01 0.397
R-HSA-73857 RNA Polymerase II Transcription 4.023510e-01 0.395
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.044036e-01 0.393
R-HSA-913709 O-linked glycosylation of mucins 4.085143e-01 0.389
R-HSA-167172 Transcription of the HIV genome 4.085143e-01 0.389
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 4.085143e-01 0.389
R-HSA-69275 G2/M Transition 4.135873e-01 0.383
R-HSA-1852241 Organelle biogenesis and maintenance 4.164682e-01 0.380
R-HSA-204005 COPII-mediated vesicle transport 4.166513e-01 0.380
R-HSA-448424 Interleukin-17 signaling 4.166513e-01 0.380
R-HSA-9764560 Regulation of CDH1 Gene Transcription 4.166513e-01 0.380
R-HSA-453274 Mitotic G2-G2/M phases 4.183550e-01 0.378
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 4.206781e-01 0.376
R-HSA-5620920 Cargo trafficking to the periciliary membrane 4.206781e-01 0.376
R-HSA-112315 Transmission across Chemical Synapses 4.219750e-01 0.375
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.246774e-01 0.372
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 4.278323e-01 0.369
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 4.286493e-01 0.368
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 4.286493e-01 0.368
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 4.286493e-01 0.368
R-HSA-3700989 Transcriptional Regulation by TP53 4.318662e-01 0.365
R-HSA-72163 mRNA Splicing - Major Pathway 4.325411e-01 0.364
R-HSA-674695 RNA Polymerase II Pre-transcription Events 4.325941e-01 0.364
R-HSA-69473 G2/M DNA damage checkpoint 4.325941e-01 0.364
R-HSA-380287 Centrosome maturation 4.365118e-01 0.360
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 4.365118e-01 0.360
R-HSA-5689603 UCH proteinases 4.404028e-01 0.356
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 4.465441e-01 0.350
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 4.481050e-01 0.349
R-HSA-416482 G alpha (12/13) signalling events 4.481050e-01 0.349
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.557021e-01 0.341
R-HSA-72172 mRNA Splicing 4.580673e-01 0.339
R-HSA-5693607 Processing of DNA double-strand break ends 4.594617e-01 0.338
R-HSA-449147 Signaling by Interleukins 4.607067e-01 0.337
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.705868e-01 0.327
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.705868e-01 0.327
R-HSA-6802957 Oncogenic MAPK signaling 4.742445e-01 0.324
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 4.778772e-01 0.321
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 4.814849e-01 0.317
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 4.886265e-01 0.311
R-HSA-9663891 Selective autophagy 4.886265e-01 0.311
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 4.956707e-01 0.305
R-HSA-2682334 EPH-Ephrin signaling 5.060569e-01 0.296
R-HSA-8878171 Transcriptional regulation by RUNX1 5.070868e-01 0.295
R-HSA-1474290 Collagen formation 5.128631e-01 0.290
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 5.195763e-01 0.284
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.228984e-01 0.282
R-HSA-157579 Telomere Maintenance 5.261978e-01 0.279
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.261978e-01 0.279
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.294745e-01 0.276
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.294745e-01 0.276
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.294745e-01 0.276
R-HSA-422356 Regulation of insulin secretion 5.294745e-01 0.276
R-HSA-193704 p75 NTR receptor-mediated signalling 5.327288e-01 0.273
R-HSA-192105 Synthesis of bile acids and bile salts 5.327288e-01 0.273
R-HSA-9020702 Interleukin-1 signaling 5.391706e-01 0.268
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 5.486687e-01 0.261
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 5.548927e-01 0.256
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 5.640695e-01 0.249
R-HSA-9679506 SARS-CoV Infections 5.642172e-01 0.249
R-HSA-975155 MyD88 dependent cascade initiated on endosome 5.670866e-01 0.246
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 5.700830e-01 0.244
R-HSA-166166 MyD88-independent TLR4 cascade 5.700830e-01 0.244
R-HSA-194068 Bile acid and bile salt metabolism 5.700830e-01 0.244
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 5.789494e-01 0.237
R-HSA-2262752 Cellular responses to stress 5.797909e-01 0.237
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 5.818645e-01 0.235
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 5.876346e-01 0.231
R-HSA-373760 L1CAM interactions 5.933259e-01 0.227
R-HSA-9007101 Rab regulation of trafficking 5.961422e-01 0.225
R-HSA-2980736 Peptide hormone metabolism 5.961422e-01 0.225
R-HSA-5693538 Homology Directed Repair 5.989393e-01 0.223
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.017171e-01 0.221
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.017171e-01 0.221
R-HSA-73886 Chromosome Maintenance 6.072157e-01 0.217
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.099367e-01 0.215
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.099367e-01 0.215
R-HSA-2132295 MHC class II antigen presentation 6.126390e-01 0.213
R-HSA-69481 G2/M Checkpoints 6.258749e-01 0.204
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 6.406595e-01 0.193
R-HSA-9909396 Circadian clock 6.411675e-01 0.193
R-HSA-1474228 Degradation of the extracellular matrix 6.411675e-01 0.193
R-HSA-163685 Integration of energy metabolism 6.534369e-01 0.185
R-HSA-5173105 O-linked glycosylation 6.558404e-01 0.183
R-HSA-9948299 Ribosome-associated quality control 6.582274e-01 0.182
R-HSA-112316 Neuronal System 6.587082e-01 0.181
R-HSA-1632852 Macroautophagy 6.652905e-01 0.177
R-HSA-2871837 FCERI mediated NF-kB activation 6.744832e-01 0.171
R-HSA-199977 ER to Golgi Anterograde Transport 6.812132e-01 0.167
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.834258e-01 0.165
R-HSA-69242 S Phase 6.834258e-01 0.165
R-HSA-9856651 MITF-M-dependent gene expression 6.878053e-01 0.163
R-HSA-9755511 KEAP1-NFE2L2 pathway 6.899725e-01 0.161
R-HSA-5693532 DNA Double-Strand Break Repair 6.942623e-01 0.158
R-HSA-69306 DNA Replication 6.942623e-01 0.158
R-HSA-1474244 Extracellular matrix organization 6.991404e-01 0.155
R-HSA-8953897 Cellular responses to stimuli 7.004608e-01 0.155
R-HSA-9612973 Autophagy 7.005869e-01 0.155
R-HSA-8953854 Metabolism of RNA 7.085882e-01 0.150
R-HSA-9006936 Signaling by TGFB family members 7.088184e-01 0.149
R-HSA-5633007 Regulation of TP53 Activity 7.088184e-01 0.149
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.340528e-01 0.134
R-HSA-5689880 Ub-specific processing proteases 7.359016e-01 0.133
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 7.359016e-01 0.133
R-HSA-9764265 Regulation of CDH1 Expression and Function 7.359016e-01 0.133
R-HSA-422475 Axon guidance 7.523273e-01 0.124
R-HSA-201681 TCF dependent signaling in response to WNT 7.537033e-01 0.123
R-HSA-3781865 Diseases of glycosylation 7.554167e-01 0.122
R-HSA-168898 Toll-like Receptor Cascades 7.670842e-01 0.115
R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.702113e-01 0.113
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 7.750787e-01 0.111
R-HSA-389948 Co-inhibition by PD-1 7.812780e-01 0.107
R-HSA-948021 Transport to the Golgi and subsequent modification 7.843138e-01 0.106
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 7.858161e-01 0.105
R-HSA-376176 Signaling by ROBO receptors 7.858161e-01 0.105
R-HSA-9675108 Nervous system development 7.894941e-01 0.103
R-HSA-9730414 MITF-M-regulated melanocyte development 8.016716e-01 0.096
R-HSA-418990 Adherens junctions interactions 8.084887e-01 0.092
R-HSA-1266738 Developmental Biology 8.109641e-01 0.091
R-HSA-421270 Cell-cell junction organization 8.480091e-01 0.072
R-HSA-388841 Regulation of T cell activation by CD28 family 8.532457e-01 0.069
R-HSA-9711123 Cellular response to chemical stress 8.650954e-01 0.063
R-HSA-76002 Platelet activation, signaling and aggregation 8.706596e-01 0.060
R-HSA-446728 Cell junction organization 8.742420e-01 0.058
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.777261e-01 0.057
R-HSA-195721 Signaling by WNT 8.907315e-01 0.050
R-HSA-1500931 Cell-Cell communication 9.037297e-01 0.044
R-HSA-9824446 Viral Infection Pathways 9.037537e-01 0.044
R-HSA-8957322 Metabolism of steroids 9.090031e-01 0.041
R-HSA-168256 Immune System 9.303152e-01 0.031
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.448751e-01 0.025
R-HSA-418594 G alpha (i) signalling events 9.497213e-01 0.022
R-HSA-446203 Asparagine N-linked glycosylation 9.547904e-01 0.020
R-HSA-5668914 Diseases of metabolism 9.563648e-01 0.019
R-HSA-72766 Translation 9.569793e-01 0.019
R-HSA-388396 GPCR downstream signalling 9.754790e-01 0.011
R-HSA-1280218 Adaptive Immune System 9.803687e-01 0.009
R-HSA-372790 Signaling by GPCR 9.853274e-01 0.006
R-HSA-500792 GPCR ligand binding 9.862473e-01 0.006
R-HSA-5663205 Infectious disease 9.936161e-01 0.003
R-HSA-109582 Hemostasis 9.966287e-01 0.001
R-HSA-168249 Innate Immune System 9.993292e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999819e-01 0.000
R-HSA-1430728 Metabolism 9.999999e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
BMPR1BBMPR1B 0.763 0.348 1 0.644
GRK1GRK1 0.760 0.279 -2 0.755
COTCOT 0.759 0.197 2 0.745
CDC7CDC7 0.756 0.156 1 0.507
MOSMOS 0.756 0.271 1 0.441
KISKIS 0.748 0.056 1 0.257
CLK3CLK3 0.746 0.075 1 0.352
BMPR1ABMPR1A 0.743 0.253 1 0.622
TGFBR1TGFBR1 0.739 0.193 -2 0.649
DSTYKDSTYK 0.739 0.056 2 0.765
GRK7GRK7 0.738 0.161 1 0.436
CK2A2CK2A2 0.738 0.197 1 0.590
ACVR2BACVR2B 0.738 0.251 -2 0.629
IKKBIKKB 0.737 -0.035 -2 0.612
GRK2GRK2 0.737 0.254 -2 0.625
PRPKPRPK 0.735 -0.021 -1 0.630
MTORMTOR 0.735 -0.053 1 0.308
GRK6GRK6 0.734 0.152 1 0.507
ACVR2AACVR2A 0.734 0.218 -2 0.613
CDK1CDK1 0.734 0.043 1 0.304
RAF1RAF1 0.734 -0.004 1 0.396
GCN2GCN2 0.732 -0.088 2 0.656
GRK3GRK3 0.732 0.220 -2 0.611
SKMLCKSKMLCK 0.732 0.074 -2 0.723
CK2A1CK2A1 0.732 0.209 1 0.607
GRK5GRK5 0.731 0.058 -3 0.810
PIM3PIM3 0.731 -0.009 -3 0.714
IKKAIKKA 0.731 -0.009 -2 0.603
DRAK1DRAK1 0.730 0.293 1 0.604
IKKEIKKE 0.728 -0.115 1 0.296
CAMK2GCAMK2G 0.728 -0.001 2 0.703
NLKNLK 0.728 -0.031 1 0.347
TBK1TBK1 0.727 -0.136 1 0.292
ERK5ERK5 0.727 -0.052 1 0.331
NDR2NDR2 0.727 -0.029 -3 0.717
ALK4ALK4 0.727 0.135 -2 0.676
BMPR2BMPR2 0.727 -0.045 -2 0.704
ATRATR 0.726 -0.062 1 0.333
GRK4GRK4 0.726 0.044 -2 0.728
ALK2ALK2 0.725 0.142 -2 0.670
TGFBR2TGFBR2 0.725 -0.002 -2 0.629
CDK3CDK3 0.724 0.046 1 0.251
PDHK4PDHK4 0.724 -0.185 1 0.361
PRKD1PRKD1 0.723 -0.022 -3 0.697
HIPK4HIPK4 0.723 -0.041 1 0.296
CAMK1BCAMK1B 0.723 -0.016 -3 0.755
JNK2JNK2 0.723 0.005 1 0.256
RIPK3RIPK3 0.722 -0.022 3 0.617
MST4MST4 0.722 -0.027 2 0.697
CHAK2CHAK2 0.721 -0.051 -1 0.560
DYRK2DYRK2 0.721 -0.027 1 0.281
MLK1MLK1 0.721 -0.051 2 0.661
CK1ECK1E 0.721 0.104 -3 0.531
ULK2ULK2 0.721 -0.151 2 0.620
DAPK2DAPK2 0.720 0.040 -3 0.768
CLK2CLK2 0.720 0.061 -3 0.620
RSK2RSK2 0.720 0.004 -3 0.637
HUNKHUNK 0.720 -0.002 2 0.690
NEK6NEK6 0.720 -0.094 -2 0.664
DLKDLK 0.720 0.069 1 0.430
FAM20CFAM20C 0.718 -0.007 2 0.536
NEK7NEK7 0.718 -0.113 -3 0.825
JNK3JNK3 0.718 -0.013 1 0.254
CDKL1CDKL1 0.717 -0.041 -3 0.689
CDK8CDK8 0.717 -0.064 1 0.257
PKN2PKN2 0.717 -0.013 -3 0.724
CDK2CDK2 0.717 0.047 1 0.356
ATMATM 0.717 -0.047 1 0.306
PLK1PLK1 0.716 0.078 -2 0.604
PDHK1PDHK1 0.716 -0.228 1 0.333
P38BP38B 0.716 -0.018 1 0.249
MARK4MARK4 0.716 -0.062 4 0.881
WNK1WNK1 0.716 -0.089 -2 0.730
DYRK4DYRK4 0.716 0.005 1 0.257
CAMLCKCAMLCK 0.715 -0.028 -2 0.698
P38GP38G 0.715 -0.025 1 0.241
CDK19CDK19 0.715 -0.057 1 0.239
NUAK2NUAK2 0.715 -0.030 -3 0.717
BCKDKBCKDK 0.715 -0.140 -1 0.542
CAMK2BCAMK2B 0.715 0.020 2 0.697
PASKPASK 0.715 0.185 -3 0.741
HIPK2HIPK2 0.714 -0.027 1 0.238
MAPKAPK2MAPKAPK2 0.714 -0.012 -3 0.568
ULK1ULK1 0.714 -0.118 -3 0.797
CAMK2ACAMK2A 0.713 0.034 2 0.722
MLK3MLK3 0.713 -0.025 2 0.589
CDK18CDK18 0.713 -0.034 1 0.241
P90RSKP90RSK 0.713 -0.032 -3 0.652
CDK7CDK7 0.713 -0.062 1 0.271
NIKNIK 0.712 -0.102 -3 0.787
PKN3PKN3 0.712 -0.071 -3 0.715
NDR1NDR1 0.712 -0.081 -3 0.705
CAMK2DCAMK2D 0.712 -0.068 -3 0.722
MASTLMASTL 0.712 -0.125 -2 0.662
SRPK1SRPK1 0.712 -0.046 -3 0.633
PRKD2PRKD2 0.712 -0.044 -3 0.620
CK1DCK1D 0.711 0.094 -3 0.483
CDK17CDK17 0.711 -0.037 1 0.240
TSSK2TSSK2 0.710 -0.020 -5 0.800
AURCAURC 0.710 -0.010 -2 0.545
P38DP38D 0.710 -0.024 1 0.184
CDKL5CDKL5 0.710 -0.063 -3 0.674
RSK4RSK4 0.710 0.021 -3 0.603
CDK5CDK5 0.710 -0.028 1 0.281
AURAAURA 0.710 0.017 -2 0.529
TTBK2TTBK2 0.709 -0.099 2 0.542
YSK4YSK4 0.709 -0.061 1 0.350
P38AP38A 0.709 -0.040 1 0.272
ERK1ERK1 0.709 -0.046 1 0.232
RIPK1RIPK1 0.708 -0.106 1 0.349
ICKICK 0.708 -0.066 -3 0.722
CDK13CDK13 0.707 -0.072 1 0.246
MAPKAPK3MAPKAPK3 0.707 -0.071 -3 0.630
RSK3RSK3 0.707 -0.063 -3 0.640
MEK1MEK1 0.707 -0.006 2 0.707
PIM1PIM1 0.707 -0.051 -3 0.641
JNK1JNK1 0.707 -0.003 1 0.266
MLK2MLK2 0.707 -0.139 2 0.666
MSK1MSK1 0.706 0.006 -3 0.613
AMPKA1AMPKA1 0.706 -0.088 -3 0.730
CLK4CLK4 0.706 -0.015 -3 0.641
MYLK4MYLK4 0.706 0.027 -2 0.642
PKACGPKACG 0.706 -0.070 -2 0.600
CK1A2CK1A2 0.706 0.080 -3 0.477
MEKK3MEKK3 0.706 0.043 1 0.392
PLK3PLK3 0.705 -0.034 2 0.685
ANKRD3ANKRD3 0.705 -0.108 1 0.378
MLK4MLK4 0.705 -0.042 2 0.565
PRP4PRP4 0.705 0.018 -3 0.786
MARK3MARK3 0.705 -0.002 4 0.821
LATS1LATS1 0.704 -0.013 -3 0.740
NEK9NEK9 0.704 -0.186 2 0.663
PKCDPKCD 0.704 -0.088 2 0.624
P70S6KBP70S6KB 0.704 -0.060 -3 0.667
LATS2LATS2 0.704 -0.089 -5 0.616
HIPK1HIPK1 0.703 -0.043 1 0.282
DNAPKDNAPK 0.703 -0.079 1 0.212
SMG1SMG1 0.702 -0.104 1 0.276
MSK2MSK2 0.702 -0.052 -3 0.609
MST3MST3 0.702 0.036 2 0.703
WNK3WNK3 0.702 -0.237 1 0.313
PKRPKR 0.702 -0.100 1 0.348
BRSK1BRSK1 0.701 -0.032 -3 0.661
IRE1IRE1 0.701 -0.141 1 0.306
TSSK1TSSK1 0.701 -0.074 -3 0.753
CDK12CDK12 0.701 -0.072 1 0.234
PAK1PAK1 0.701 -0.080 -2 0.657
QSKQSK 0.701 -0.055 4 0.855
TLK2TLK2 0.699 -0.124 1 0.314
PKCBPKCB 0.699 -0.069 2 0.580
CLK1CLK1 0.699 -0.028 -3 0.609
CAMK4CAMK4 0.699 -0.092 -3 0.687
ERK2ERK2 0.699 -0.067 1 0.245
PKACBPKACB 0.698 -0.026 -2 0.542
MNK2MNK2 0.698 -0.075 -2 0.633
DYRK1BDYRK1B 0.698 -0.049 1 0.273
PKCGPKCG 0.698 -0.071 2 0.584
AMPKA2AMPKA2 0.698 -0.097 -3 0.686
NIM1NIM1 0.698 -0.153 3 0.660
PRKXPRKX 0.698 -0.006 -3 0.525
QIKQIK 0.697 -0.098 -3 0.724
PKCAPKCA 0.697 -0.079 2 0.569
CDK16CDK16 0.697 -0.039 1 0.230
SRPK3SRPK3 0.697 -0.059 -3 0.613
VRK2VRK2 0.697 -0.218 1 0.355
SRPK2SRPK2 0.696 -0.066 -3 0.543
GAKGAK 0.696 0.070 1 0.389
PRKD3PRKD3 0.696 -0.059 -3 0.613
MARK2MARK2 0.696 -0.037 4 0.789
AURBAURB 0.696 -0.039 -2 0.540
CK1G1CK1G1 0.696 -0.025 -3 0.545
MPSK1MPSK1 0.695 -0.035 1 0.295
MARK1MARK1 0.695 -0.024 4 0.846
CDK9CDK9 0.695 -0.090 1 0.246
PAK3PAK3 0.695 -0.125 -2 0.646
GCKGCK 0.694 0.072 1 0.412
ZAKZAK 0.694 -0.092 1 0.360
CDK14CDK14 0.694 -0.048 1 0.264
TAO3TAO3 0.693 -0.040 1 0.360
NEK11NEK11 0.693 -0.009 1 0.367
MNK1MNK1 0.693 -0.076 -2 0.645
CHAK1CHAK1 0.693 -0.161 2 0.622
PKCZPKCZ 0.692 -0.118 2 0.613
PLK2PLK2 0.692 0.016 -3 0.761
PAK2PAK2 0.692 -0.105 -2 0.644
BRAFBRAF 0.692 -0.076 -4 0.776
CDK10CDK10 0.692 -0.043 1 0.261
PLK4PLK4 0.692 -0.133 2 0.504
MEK5MEK5 0.692 -0.124 2 0.680
SIKSIK 0.691 -0.092 -3 0.625
DYRK1ADYRK1A 0.691 -0.071 1 0.271
BRSK2BRSK2 0.691 -0.106 -3 0.685
HIPK3HIPK3 0.691 -0.079 1 0.252
NEK2NEK2 0.691 -0.180 2 0.644
DYRK3DYRK3 0.691 -0.054 1 0.280
CK1ACK1A 0.690 0.108 -3 0.407
PAK6PAK6 0.690 -0.070 -2 0.588
PKCHPKCH 0.690 -0.098 2 0.560
PKG2PKG2 0.690 -0.061 -2 0.544
DAPK1DAPK1 0.689 0.062 -3 0.655
IRE2IRE2 0.689 -0.175 2 0.579
PERKPERK 0.689 -0.150 -2 0.675
AKT2AKT2 0.689 -0.046 -3 0.550
TLK1TLK1 0.688 -0.111 -2 0.665
CAMK1GCAMK1G 0.688 -0.049 -3 0.630
PHKG1PHKG1 0.688 -0.143 -3 0.694
MEKK2MEKK2 0.688 -0.121 2 0.644
SMMLCKSMMLCK 0.688 -0.017 -3 0.700
NUAK1NUAK1 0.687 -0.112 -3 0.653
SGK3SGK3 0.687 -0.084 -3 0.625
MST2MST2 0.686 -0.021 1 0.385
MEKK1MEKK1 0.686 -0.180 1 0.326
HPK1HPK1 0.686 0.020 1 0.398
MELKMELK 0.686 -0.138 -3 0.671
GSK3AGSK3A 0.685 -0.001 4 0.448
SNRKSNRK 0.685 -0.152 2 0.571
TAK1TAK1 0.684 0.014 1 0.362
PINK1PINK1 0.684 -0.177 1 0.312
NEK5NEK5 0.684 -0.172 1 0.318
DAPK3DAPK3 0.684 0.003 -3 0.669
TTBK1TTBK1 0.684 -0.125 2 0.480
CHK1CHK1 0.683 -0.103 -3 0.681
GSK3BGSK3B 0.683 -0.006 4 0.439
HRIHRI 0.683 -0.199 -2 0.659
MAPKAPK5MAPKAPK5 0.682 -0.136 -3 0.591
PIM2PIM2 0.682 -0.076 -3 0.608
CAMKK1CAMKK1 0.681 -0.120 -2 0.617
WNK4WNK4 0.681 -0.183 -2 0.724
DCAMKL1DCAMKL1 0.680 -0.114 -3 0.646
MINKMINK 0.680 -0.064 1 0.340
LKB1LKB1 0.680 -0.111 -3 0.795
MAP3K15MAP3K15 0.679 -0.103 1 0.320
CDK6CDK6 0.679 -0.062 1 0.231
MAKMAK 0.678 -0.034 -2 0.649
NEK8NEK8 0.678 -0.138 2 0.664
TXKTXK 0.678 0.317 1 0.574
PKACAPKACA 0.678 -0.049 -2 0.500
ERK7ERK7 0.677 -0.059 2 0.416
EEF2KEEF2K 0.677 -0.056 3 0.745
IRAK4IRAK4 0.676 -0.200 1 0.288
PTK2PTK2 0.676 0.345 -1 0.721
MEKK6MEKK6 0.676 -0.120 1 0.326
SSTKSSTK 0.676 -0.104 4 0.851
TAO2TAO2 0.676 -0.127 2 0.685
BMPR2_TYRBMPR2_TYR 0.676 0.344 -1 0.703
PKCTPKCT 0.675 -0.130 2 0.563
PKCEPKCE 0.675 -0.058 2 0.567
TNIKTNIK 0.674 -0.080 3 0.787
CAMKK2CAMKK2 0.674 -0.147 -2 0.611
PKCIPKCI 0.673 -0.107 2 0.574
DCAMKL2DCAMKL2 0.673 -0.106 -3 0.674
BUB1BUB1 0.673 0.004 -5 0.801
KHS2KHS2 0.672 -0.035 1 0.358
P70S6KP70S6K 0.672 -0.096 -3 0.570
AKT1AKT1 0.672 -0.078 -3 0.562
CDK4CDK4 0.671 -0.081 1 0.224
PDK1PDK1 0.671 -0.153 1 0.308
SYKSYK 0.671 0.297 -1 0.694
HGKHGK 0.671 -0.130 3 0.763
MST1MST1 0.671 -0.084 1 0.355
KHS1KHS1 0.671 -0.084 1 0.323
PAK5PAK5 0.671 -0.102 -2 0.531
IRAK1IRAK1 0.670 -0.210 -1 0.487
CAMK1DCAMK1D 0.670 -0.072 -3 0.528
NEK4NEK4 0.670 -0.193 1 0.302
VRK1VRK1 0.670 -0.127 2 0.683
PHKG2PHKG2 0.669 -0.156 -3 0.668
PDHK3_TYRPDHK3_TYR 0.669 0.145 4 0.923
FYNFYN 0.667 0.217 -1 0.706
PDHK4_TYRPDHK4_TYR 0.667 0.180 2 0.792
MOKMOK 0.667 -0.072 1 0.281
STK33STK33 0.667 -0.122 2 0.503
PAK4PAK4 0.666 -0.093 -2 0.538
LRRK2LRRK2 0.666 -0.163 2 0.692
PBKPBK 0.666 -0.098 1 0.306
MAP2K6_TYRMAP2K6_TYR 0.666 0.187 -1 0.646
NEK1NEK1 0.665 -0.184 1 0.307
PDHK1_TYRPDHK1_TYR 0.665 0.185 -1 0.662
OSR1OSR1 0.665 -0.040 2 0.643
RIPK2RIPK2 0.665 -0.164 1 0.323
CHK2CHK2 0.664 -0.053 -3 0.483
ALPHAK3ALPHAK3 0.664 -0.010 -1 0.575
EPHA6EPHA6 0.664 0.157 -1 0.672
YANK3YANK3 0.664 -0.032 2 0.345
SLKSLK 0.664 -0.109 -2 0.555
MEK2MEK2 0.663 -0.188 2 0.653
PKN1PKN1 0.662 -0.105 -3 0.584
ITKITK 0.662 0.186 -1 0.597
MAP2K4_TYRMAP2K4_TYR 0.661 0.046 -1 0.630
BMXBMX 0.661 0.156 -1 0.569
SRMSSRMS 0.661 0.170 1 0.491
YSK1YSK1 0.661 -0.153 2 0.639
AKT3AKT3 0.660 -0.067 -3 0.476
EPHA4EPHA4 0.660 0.130 2 0.713
SGK1SGK1 0.660 -0.063 -3 0.459
EPHB4EPHB4 0.659 0.094 -1 0.614
LOKLOK 0.659 -0.172 -2 0.594
ROCK2ROCK2 0.658 -0.092 -3 0.650
TESK1_TYRTESK1_TYR 0.658 -0.008 3 0.771
TTKTTK 0.657 -0.078 -2 0.640
LCKLCK 0.657 0.114 -1 0.683
MRCKAMRCKA 0.657 -0.089 -3 0.608
BLKBLK 0.656 0.106 -1 0.668
HASPINHASPIN 0.656 -0.088 -1 0.427
ASK1ASK1 0.655 -0.130 1 0.314
PKMYT1_TYRPKMYT1_TYR 0.655 -0.059 3 0.745
FGRFGR 0.655 0.053 1 0.423
MRCKBMRCKB 0.654 -0.097 -3 0.597
CAMK1ACAMK1A 0.654 -0.078 -3 0.500
PTK2BPTK2B 0.654 0.160 -1 0.548
EPHB2EPHB2 0.654 0.104 -1 0.610
EPHB1EPHB1 0.654 0.112 1 0.470
MAP2K7_TYRMAP2K7_TYR 0.654 -0.100 2 0.737
HCKHCK 0.653 0.076 -1 0.657
BIKEBIKE 0.653 -0.069 1 0.304
FERFER 0.652 0.035 1 0.441
DMPK1DMPK1 0.652 -0.053 -3 0.614
MYO3BMYO3B 0.651 -0.118 2 0.658
SBKSBK 0.651 -0.075 -3 0.412
YES1YES1 0.650 0.013 -1 0.618
METMET 0.650 0.068 3 0.672
ABL2ABL2 0.649 -0.019 -1 0.574
INSRRINSRR 0.649 0.057 3 0.623
JAK3JAK3 0.649 -0.001 1 0.316
SRCSRC 0.648 0.097 -1 0.652
MYO3AMYO3A 0.648 -0.114 1 0.317
CK1G2CK1G2 0.648 0.073 -3 0.460
CSF1RCSF1R 0.648 -0.047 3 0.681
EPHB3EPHB3 0.648 0.042 -1 0.604
KITKIT 0.648 0.003 3 0.682
PINK1_TYRPINK1_TYR 0.648 -0.102 1 0.370
EPHA7EPHA7 0.647 0.083 2 0.690
ERBB4ERBB4 0.646 0.119 1 0.399
ZAP70ZAP70 0.646 0.123 -1 0.638
EPHA8EPHA8 0.646 0.110 -1 0.638
ABL1ABL1 0.645 -0.042 -1 0.564
TECTEC 0.645 0.055 -1 0.514
MERTKMERTK 0.645 0.029 3 0.657
MST1RMST1R 0.644 -0.105 3 0.703
TYRO3TYRO3 0.644 -0.082 3 0.690
NEK3NEK3 0.644 -0.241 1 0.255
TAO1TAO1 0.644 -0.158 1 0.276
RETRET 0.643 -0.170 1 0.307
FRKFRK 0.642 0.040 -1 0.633
EPHA2EPHA2 0.642 0.122 -1 0.622
ROS1ROS1 0.642 -0.115 3 0.658
PKG1PKG1 0.642 -0.115 -2 0.471
EPHA5EPHA5 0.642 0.080 2 0.701
EGFREGFR 0.642 0.016 1 0.325
FLT1FLT1 0.642 0.043 -1 0.640
ROCK1ROCK1 0.642 -0.103 -3 0.610
EPHA3EPHA3 0.641 0.042 2 0.673
LYNLYN 0.641 0.040 3 0.611
AAK1AAK1 0.641 -0.052 1 0.245
STLK3STLK3 0.641 -0.144 1 0.332
LIMK2_TYRLIMK2_TYR 0.641 -0.148 -3 0.804
ERBB2ERBB2 0.641 0.007 1 0.354
CK1G3CK1G3 0.640 -0.012 -3 0.368
CRIKCRIK 0.640 -0.085 -3 0.549
JAK2JAK2 0.639 -0.188 1 0.284
LIMK1_TYRLIMK1_TYR 0.638 -0.189 2 0.693
TYK2TYK2 0.637 -0.246 1 0.289
WEE1_TYRWEE1_TYR 0.636 -0.035 -1 0.534
FGFR2FGFR2 0.636 -0.089 3 0.666
NTRK3NTRK3 0.635 -0.033 -1 0.570
YANK2YANK2 0.635 -0.040 2 0.352
DDR1DDR1 0.635 -0.148 4 0.863
KDRKDR 0.635 -0.066 3 0.636
BTKBTK 0.635 -0.059 -1 0.539
JAK1JAK1 0.634 -0.127 1 0.270
INSRINSR 0.634 -0.040 3 0.614
FGFR3FGFR3 0.634 -0.035 3 0.642
TNK2TNK2 0.633 -0.107 3 0.647
NTRK1NTRK1 0.633 -0.065 -1 0.588
MATKMATK 0.633 -0.024 -1 0.516
TEKTEK 0.632 -0.079 3 0.629
FLT3FLT3 0.632 -0.132 3 0.683
FESFES 0.631 0.089 -1 0.542
CSKCSK 0.631 -0.043 2 0.685
AXLAXL 0.631 -0.102 3 0.653
FGFR4FGFR4 0.631 -0.032 -1 0.564
EPHA1EPHA1 0.630 -0.049 3 0.647
PDGFRBPDGFRB 0.630 -0.158 3 0.684
ALKALK 0.629 -0.096 3 0.598
IGF1RIGF1R 0.628 0.008 3 0.561
FGFR1FGFR1 0.627 -0.161 3 0.641
LTKLTK 0.626 -0.124 3 0.625
PTK6PTK6 0.626 -0.158 -1 0.511
NTRK2NTRK2 0.625 -0.122 3 0.639
NEK10_TYRNEK10_TYR 0.625 -0.190 1 0.220
TNNI3K_TYRTNNI3K_TYR 0.623 -0.173 1 0.289
FLT4FLT4 0.623 -0.106 3 0.634
DDR2DDR2 0.619 -0.089 3 0.607
PDGFRAPDGFRA 0.619 -0.227 3 0.692
MUSKMUSK 0.617 -0.086 1 0.312
TNK1TNK1 0.617 -0.229 3 0.672