Motif 430 (n=224)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1613 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| B2RTY4 | MYO9A | S812 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| B2RTY4 | MYO9A | S1363 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| H8Y6P7 | GCOM1 | S506 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | None |
| O00151 | PDLIM1 | S152 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O14715 | RGPD8 | S1612 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14986 | PIP5K1B | S447 | ochoa | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). {ECO:0000250|UniProtKB:P70181, ECO:0000250|UniProtKB:Q99755}. |
| O15164 | TRIM24 | S612 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15164 | TRIM24 | S767 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15355 | PPM1G | S242 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15534 | PER1 | S1039 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43164 | PJA2 | S241 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43166 | SIPA1L1 | S93 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43865 | AHCYL1 | S84 | ochoa | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}. |
| O60271 | SPAG9 | S363 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60271 | SPAG9 | S593 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60292 | SIPA1L3 | S1306 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60296 | TRAK2 | S459 | ochoa | Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) | May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}. |
| O60353 | FZD6 | S673 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| O60583 | CCNT2 | S706 | ochoa | Cyclin-T2 (CycT2) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}. |
| O75448 | MED24 | S862 | ochoa | Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}. |
| O75914 | PAK3 | S154 | psp | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O75962 | TRIO | S1723 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O75970 | MPDZ | S1820 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O94808 | GFPT2 | S244 | ochoa | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. |
| O94880 | PHF14 | S571 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95071 | UBR5 | S1732 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95343 | SIX3 | S308 | ochoa | Homeobox protein SIX3 (Sine oculis homeobox homolog 3) | Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 also functions in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway. {ECO:0000250|UniProtKB:Q62233, ECO:0000269|PubMed:18791198}. |
| O95999 | BCL10 | S170 | psp | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| P04049 | RAF1 | Y232 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P05107 | ITGB2 | S489 | ochoa | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}. |
| P09769 | FGR | S57 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0CAP2 | POLR2M | S109 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}. |
| P0DJD0 | RGPD1 | S1597 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1605 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P13994 | YJU2B | S366 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
| P15291 | B4GALT1 | S73 | ochoa | Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] | [Beta-1,4-galactosyltransferase 1]: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. {ECO:0000269|PubMed:34855475}.; FUNCTION: [Processed beta-1,4-galactosyltransferase 1]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. {ECO:0000269|PubMed:16157350}. |
| P15336 | ATF2 | S437 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P20273 | CD22 | S725 | ochoa | B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) | Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration (PubMed:20172905). Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling (PubMed:8627166). If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced (PubMed:20516366). {ECO:0000269|PubMed:20172905, ECO:0000269|PubMed:20516366, ECO:0000269|PubMed:34330755, ECO:0000269|PubMed:8627166}. |
| P21333 | FLNA | S2338 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21359 | NF1 | S882 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P21860 | ERBB3 | S1051 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P25054 | APC | S1234 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P28066 | PSMA5 | S179 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P30260 | CDC27 | S219 | ochoa|psp | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P30414 | NKTR | S470 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | S514 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P31629 | HIVEP2 | S950 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35613 | BSG | S367 | ochoa | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| P41236 | PPP1R2 | S23 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P43119 | PTGIR | S366 | ochoa | Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
| P46087 | NOP2 | S662 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46100 | ATRX | S1202 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46108 | CRK | S40 | ochoa | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P46109 | CRKL | S41 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P46821 | MAP1B | S1211 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48165 | GJA8 | S258 | psp | Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70) | Structural component of eye lens gap junctions (PubMed:18006672, PubMed:19756179). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:18006672, PubMed:19756179). {ECO:0000250|UniProtKB:P55917, ECO:0000269|PubMed:16397066, ECO:0000269|PubMed:18006672, ECO:0000269|PubMed:19756179, ECO:0000269|PubMed:35531093}. |
| P49792 | RANBP2 | S1832 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2588 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49916 | LIG3 | S853 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P51636 | CAV2 | S135 | psp | Caveolin-2 | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250, ECO:0000269|PubMed:15504032, ECO:0000269|PubMed:18081315}. |
| P51826 | AFF3 | S881 | ochoa | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. |
| P52594 | AGFG1 | S367 | ochoa | Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) | Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}. |
| P52701 | MSH6 | S330 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P54132 | BLM | S579 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55197 | MLLT10 | S302 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P55198 | MLLT6 | S276 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
| P78536 | ADAM17 | S785 | ochoa | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}. |
| P98171 | ARHGAP4 | S497 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q01105 | SET | S183 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01484 | ANK2 | S3764 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q03164 | KMT2A | S1240 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S2283 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q08AD1 | CAMSAP2 | S1339 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12778 | FOXO1 | S429 | ochoa | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q13233 | MAP3K1 | S923 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13480 | GAB1 | S276 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13535 | ATR | S1875 | ochoa | Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}. |
| Q13772 | NCOA4 | S553 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q14126 | DSG2 | S1059 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14469 | HES1 | S37 | psp | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}. |
| Q14515 | SPARCL1 | S90 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
| Q14677 | CLINT1 | S322 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14966 | ZNF638 | S1461 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15025 | TNIP1 | S122 | psp | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. |
| Q15032 | R3HDM1 | S393 | ochoa | R3H domain-containing protein 1 | None |
| Q15058 | KIF14 | Y1230 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15139 | PRKD1 | S548 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15772 | SPEG | S2322 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16363 | LAMA4 | S953 | ochoa | Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Q16790 | CA9 | S53 | ochoa | Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1) | Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). {ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18703501, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19805286}. |
| Q2KHR3 | QSER1 | S508 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2KHR3 | QSER1 | S1227 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2LD37 | BLTP1 | S1528 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2TB10 | ZNF800 | S160 | ochoa | Zinc finger protein 800 | May be involved in transcriptional regulation. |
| Q5BKX6 | SLC45A4 | S410 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5FWF5 | ESCO1 | S383 | ochoa | N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}. |
| Q5H9R7 | PPP6R3 | S523 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JS13 | RALGPS1 | S297 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) | Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for. {ECO:0000250, ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:10889189}. |
| Q5JTV8 | TOR1AIP1 | S227 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5QJE6 | DNTTIP2 | S37 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SW79 | CEP170 | S269 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SYE7 | NHSL1 | S165 | ochoa | NHS-like protein 1 | None |
| Q5SYE7 | NHSL1 | S857 | ochoa | NHS-like protein 1 | None |
| Q5T8P6 | RBM26 | S132 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5T9C2 | EEIG1 | S250 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5VT06 | CEP350 | S1244 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q63ZY3 | KANK2 | S71 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q658Y4 | FAM91A1 | S366 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q66K14 | TBC1D9B | S752 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q68CP9 | ARID2 | S1302 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q68DK2 | ZFYVE26 | S700 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q69YH5 | CDCA2 | S469 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6GYQ0 | RALGAPA1 | S831 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6KC79 | NIPBL | S243 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NXS1 | PPP1R2B | S23 | ochoa | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6P444 | MTFR2 | S171 | ochoa | Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) | May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}. |
| Q6P4F7 | ARHGAP11A | S339 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6UB98 | ANKRD12 | S1143 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UWH4 | GASK1B | S199 | ochoa | Golgi-associated kinase 1B (Expressed in nerve and epithelium during development) (Protein FAM198B) | None |
| Q6ZWJ1 | STXBP4 | S163 | ochoa | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
| Q70CQ2 | USP34 | S3410 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q70EL1 | USP54 | S1188 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7L804 | RAB11FIP2 | S184 | ochoa | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}. |
| Q7Z3B3 | KANSL1 | S564 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z3J3 | RGPD4 | S1613 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3S7 | CACNA2D4 | S498 | ochoa | Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}. |
| Q7Z6Z7 | HUWE1 | S2749 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S3261 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S3262 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z739 | YTHDF3 | S23 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
| Q86SQ0 | PHLDB2 | S308 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86SQ0 | PHLDB2 | S347 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UR5 | RIMS1 | S1339 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86US8 | SMG6 | S864 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86WP2 | GPBP1 | S380 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q86XJ1 | GAS2L3 | S567 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q8IVT5 | KSR1 | S184 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8IWB9 | TEX2 | S388 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IX03 | WWC1 | S434 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IYH5 | ZZZ3 | S130 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8N183 | NDUFAF2 | S148 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone (PubMed:38949024). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:38949024}. |
| Q8N2G6 | ZCCHC24 | S69 | ochoa | Zinc finger CCHC domain-containing protein 24 | None |
| Q8N3S3 | PHTF2 | S221 | ochoa | Protein PHTF2 | None |
| Q8N556 | AFAP1 | S342 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8N573 | OXR1 | S526 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5B7 | CERS5 | S355 | ochoa|psp | Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). {ECO:0000250|UniProtKB:Q9D6K9, ECO:0000269|PubMed:16951403, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}. |
| Q8NA72 | POC5 | S78 | ochoa | Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) | Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. |
| Q8NEB9 | PIK3C3 | S243 | ochoa | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8TDD1 | DDX54 | S743 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TDW5 | SYTL5 | S319 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TEW0 | PARD3 | S143 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WUY3 | PRUNE2 | S1024 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WXH0 | SYNE2 | S4158 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WXI7 | MUC16 | S9579 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q8WYL5 | SSH1 | S909 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92508 | PIEZO1 | S392 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92547 | TOPBP1 | S296 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92613 | JADE3 | S793 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92754 | TFAP2C | S22 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
| Q92870 | APBB2 | S43 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q96AJ9 | VTI1A | S110 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
| Q96GX5 | MASTL | S551 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96HH9 | GRAMD2B | S71 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96HN2 | AHCYL2 | S165 | ochoa | Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) | May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). {ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}. |
| Q96L73 | NSD1 | S571 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96MU7 | YTHDC1 | S317 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96NE9 | FRMD6 | S414 | ochoa | FERM domain-containing protein 6 (Willin) | None |
| Q96SI9 | STRBP | S465 | ochoa | Spermatid perinuclear RNA-binding protein | Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}. |
| Q96T58 | SPEN | S1005 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99666 | RGPD5 | S1612 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BSJ8 | ESYT1 | S830 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BT25 | HAUS8 | S19 | ochoa|psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BTX1 | NDC1 | S417 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9BWT3 | PAPOLG | S515 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BX66 | SORBS1 | S280 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BZI7 | UPF3B | S33 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9C0B0 | UNK | S474 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0B0 | UNK | S475 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0D5 | TANC1 | S216 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0I3 | CCSER1 | S445 | ochoa | Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) | None |
| Q9H019 | MTFR1L | S237 | ochoa | Mitochondrial fission regulator 1-like | Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}. |
| Q9H3M0 | KCNF1 | S177 | ochoa | Voltage-gated potassium channel regulatory subunit KCNF1 (Potassium voltage-gated channel subfamily F member 1) (Voltage-gated potassium channel subunit Kv5.1) (kH1) | Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone. {ECO:0000250|UniProtKB:D4ADX7}. |
| Q9H3P7 | ACBD3 | S315 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9H4H8 | FAM83D | S472 | ochoa | Protein FAM83D (Spindle protein CHICA) | Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}. |
| Q9HA77 | CARS2 | S544 | ochoa | Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) | Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). {ECO:0000269|PubMed:29079736}.; FUNCTION: In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides (PubMed:29079736). CysSSHs behave as potent antioxidants and cellular protectants (PubMed:29079736). {ECO:0000269|PubMed:29079736}. |
| Q9HC44 | GPBP1L1 | S440 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9NQC3 | RTN4 | S440 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQS1 | AVEN | S135 | psp | Cell death regulator Aven | Protects against apoptosis mediated by Apaf-1. |
| Q9NR09 | BIRC6 | S3590 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NRZ9 | HELLS | S163 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NV58 | RNF19A | S633 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9P206 | NHSL3 | S96 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P225 | DNAH2 | S340 | ochoa | Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) | As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). {ECO:0000269|PubMed:30811583}. |
| Q9P273 | TENM3 | S26 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P2Q2 | FRMD4A | S614 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UEE9 | CFDP1 | S221 | ochoa | Craniofacial development protein 1 (Bucentaur) | May play a role during embryogenesis. {ECO:0000250}. |
| Q9UH99 | SUN2 | S135 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UHB7 | AFF4 | S619 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UKL3 | CASP8AP2 | S1270 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKV5 | AMFR | S601 | ochoa | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296). Required for proper lipid homeostasis (PubMed:37119330). {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:12670940, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:17043353, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:31073040, ECO:0000269|PubMed:31953408, ECO:0000269|PubMed:36593296, ECO:0000269|PubMed:37119330}. |
| Q9UKX7 | NUP50 | S262 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULH0 | KIDINS220 | S1740 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULH1 | ASAP1 | S866 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULL8 | SHROOM4 | S154 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UMD9 | COL17A1 | S61 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UQ84 | EXO1 | S659 | ochoa | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9Y2G3 | ATP11B | S445 | ochoa | Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}. |
| Q9Y2H2 | INPP5F | S829 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y2I8 | WDR37 | S30 | ochoa | WD repeat-containing protein 37 | Required for normal ER Ca2+ handling in lymphocytes. Together with PACS1, it plays an essential role in stabilizing peripheral lymphocyte populations. {ECO:0000250|UniProtKB:Q8CBE3}. |
| Q9Y2K6 | USP20 | S304 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y2W1 | THRAP3 | S746 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3S1 | WNK2 | S1918 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4B4 | RAD54L2 | S1194 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4C8 | RBM19 | S493 | ochoa | Probable RNA-binding protein 19 (RNA-binding motif protein 19) | Plays a role in embryo pre-implantation development. {ECO:0000250}. |
| Q9Y4F5 | CEP170B | S1356 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6Q9 | NCOA3 | S776 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| O00506 | STK25 | S341 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| A0MZ66 | SHTN1 | S444 | Sugiyama | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| Q01860 | POU5F1 | S288 | PSP | POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}. |
| O75581 | LRP6 | S1430 | SIGNOR | Low-density lipoprotein receptor-related protein 6 (LRP-6) | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}. |
| P46060 | RANGAP1 | S453 | Sugiyama | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| Q9Y262 | EIF3L | S80 | Sugiyama | Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q9H7E2 | TDRD3 | S364 | Sugiyama | Tudor domain-containing protein 3 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9827857 | Specification of primordial germ cells | 0.000347 | 3.460 |
| R-HSA-1474165 | Reproduction | 0.000363 | 3.440 |
| R-HSA-8875656 | MET receptor recycling | 0.000620 | 3.208 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.001001 | 3.000 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.001913 | 2.718 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.001384 | 2.859 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.004403 | 2.356 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.003871 | 2.412 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.002818 | 2.550 |
| R-HSA-5358508 | Mismatch Repair | 0.004978 | 2.303 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.005376 | 2.270 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.003365 | 2.473 |
| R-HSA-5693538 | Homology Directed Repair | 0.003707 | 2.431 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.003365 | 2.473 |
| R-HSA-8875878 | MET promotes cell motility | 0.004667 | 2.331 |
| R-HSA-169893 | Prolonged ERK activation events | 0.003380 | 2.471 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.004667 | 2.331 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.005429 | 2.265 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.004667 | 2.331 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.003664 | 2.436 |
| R-HSA-1640170 | Cell Cycle | 0.002821 | 2.550 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.002117 | 2.674 |
| R-HSA-9675135 | Diseases of DNA repair | 0.001331 | 2.876 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 0.006388 | 2.195 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.006331 | 2.199 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.007738 | 2.111 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.008007 | 2.097 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.009371 | 2.028 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.010741 | 1.969 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.011513 | 1.939 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.012773 | 1.894 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.014610 | 1.835 |
| R-HSA-170984 | ARMS-mediated activation | 0.013830 | 1.859 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.014133 | 1.850 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.013830 | 1.859 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.014633 | 1.835 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.029008 | 1.537 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.029008 | 1.537 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.029008 | 1.537 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.029008 | 1.537 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.029008 | 1.537 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.029008 | 1.537 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.020998 | 1.678 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.016616 | 1.779 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.017849 | 1.748 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.017849 | 1.748 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.020464 | 1.689 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.020464 | 1.689 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.021846 | 1.661 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.024760 | 1.606 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.019131 | 1.718 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.023664 | 1.626 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.027873 | 1.555 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.021846 | 1.661 |
| R-HSA-9909396 | Circadian clock | 0.023288 | 1.633 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.024760 | 1.606 |
| R-HSA-69481 | G2/M Checkpoints | 0.019505 | 1.710 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.023278 | 1.633 |
| R-HSA-187687 | Signalling to ERKs | 0.024760 | 1.606 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.023664 | 1.626 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.023117 | 1.636 |
| R-HSA-9930044 | Nuclear RNA decay | 0.020464 | 1.689 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.020998 | 1.678 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.029504 | 1.530 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.032430 | 1.489 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.031185 | 1.506 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.032700 | 1.485 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.031185 | 1.506 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.032915 | 1.483 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.032915 | 1.483 |
| R-HSA-4793953 | Defective B4GALT1 causes CDG-2d | 0.043197 | 1.365 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 0.070957 | 1.149 |
| R-HSA-8865999 | MET activates PTPN11 | 0.070957 | 1.149 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.084535 | 1.073 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.084535 | 1.073 |
| R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 0.124094 | 0.906 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.124094 | 0.906 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 0.124094 | 0.906 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.136899 | 0.864 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.136899 | 0.864 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.136899 | 0.864 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.136899 | 0.864 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.136899 | 0.864 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.149517 | 0.825 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.149517 | 0.825 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.149517 | 0.825 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.049349 | 1.307 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.161951 | 0.791 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.053044 | 1.275 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.053044 | 1.275 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.053044 | 1.275 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.053044 | 1.275 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.060715 | 1.217 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.064685 | 1.189 |
| R-HSA-4839744 | Signaling by APC mutants | 0.186279 | 0.730 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.186279 | 0.730 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.186279 | 0.730 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.186279 | 0.730 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.198178 | 0.703 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.198178 | 0.703 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.077088 | 1.113 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.209904 | 0.678 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.209904 | 0.678 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.209904 | 0.678 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.209904 | 0.678 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.209904 | 0.678 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.085737 | 1.067 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.232846 | 0.633 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.232846 | 0.633 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.244067 | 0.612 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.244067 | 0.612 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.244067 | 0.612 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.244067 | 0.612 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.255124 | 0.593 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.255124 | 0.593 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.255124 | 0.593 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.255124 | 0.593 |
| R-HSA-5673000 | RAF activation | 0.122864 | 0.911 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.266021 | 0.575 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.266021 | 0.575 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.276758 | 0.558 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.276758 | 0.558 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.045106 | 1.346 |
| R-HSA-180292 | GAB1 signalosome | 0.287340 | 0.542 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.287340 | 0.542 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.297767 | 0.526 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.297767 | 0.526 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.297767 | 0.526 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.094067 | 1.027 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.163047 | 0.788 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.308042 | 0.511 |
| R-HSA-210991 | Basigin interactions | 0.318167 | 0.497 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.318167 | 0.497 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.189201 | 0.723 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.189201 | 0.723 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.194500 | 0.711 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.337978 | 0.471 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.210505 | 0.677 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.347667 | 0.459 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.221247 | 0.655 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.221247 | 0.655 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.226635 | 0.645 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.226635 | 0.645 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.366623 | 0.436 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.237438 | 0.624 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.242850 | 0.615 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.242850 | 0.615 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.313248 | 0.504 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.085737 | 1.067 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.244067 | 0.612 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.189201 | 0.723 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.189201 | 0.723 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.149517 | 0.825 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.163047 | 0.788 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.049750 | 1.303 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.328145 | 0.484 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.287340 | 0.542 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.308042 | 0.511 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.189201 | 0.723 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.339760 | 0.469 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.339760 | 0.469 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.084535 | 1.073 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.161951 | 0.791 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.161951 | 0.791 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.209904 | 0.678 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.323997 | 0.489 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.323997 | 0.489 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.042259 | 1.374 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.225047 | 0.648 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.339760 | 0.469 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.118030 | 0.928 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.097915 | 1.009 |
| R-HSA-5653890 | Lactose synthesis | 0.124094 | 0.906 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.149517 | 0.825 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.186279 | 0.730 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.232846 | 0.633 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.113247 | 0.946 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.137640 | 0.861 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.276758 | 0.558 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.094661 | 1.024 |
| R-HSA-373752 | Netrin-1 signaling | 0.178665 | 0.748 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.318167 | 0.497 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.226635 | 0.645 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.280797 | 0.552 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.318627 | 0.497 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.186279 | 0.730 |
| R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 0.198178 | 0.703 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.108515 | 0.965 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.074737 | 1.126 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.043243 | 1.364 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.209904 | 0.678 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.161951 | 0.791 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.266021 | 0.575 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.163047 | 0.788 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.080175 | 1.096 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.042295 | 1.374 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.264538 | 0.578 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.043197 | 1.365 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.035594 | 1.449 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.136899 | 0.864 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.042259 | 1.374 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.149517 | 0.825 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.161951 | 0.791 |
| R-HSA-2534343 | Interaction With Cumulus Cells And The Zona Pellucida | 0.161951 | 0.791 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.174204 | 0.759 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.198178 | 0.703 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.198178 | 0.703 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.209904 | 0.678 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.209904 | 0.678 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.044315 | 1.353 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.244067 | 0.612 |
| R-HSA-1221632 | Meiotic synapsis | 0.062148 | 1.207 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.266021 | 0.575 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.287340 | 0.542 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.163047 | 0.788 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.357215 | 0.447 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.357215 | 0.447 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.232032 | 0.634 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.094661 | 1.024 |
| R-HSA-9834899 | Specification of the neural plate border | 0.049349 | 1.307 |
| R-HSA-3000157 | Laminin interactions | 0.366623 | 0.436 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.357215 | 0.447 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.049349 | 1.307 |
| R-HSA-157579 | Telomere Maintenance | 0.076726 | 1.115 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.287340 | 0.542 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.340039 | 0.468 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.161951 | 0.791 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.161951 | 0.791 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.081376 | 1.090 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.337978 | 0.471 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.215870 | 0.666 |
| R-HSA-73886 | Chromosome Maintenance | 0.139753 | 0.855 |
| R-HSA-180786 | Extension of Telomeres | 0.077377 | 1.111 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.095033 | 1.022 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.161951 | 0.791 |
| R-HSA-69239 | Synthesis of DNA | 0.256159 | 0.591 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.275389 | 0.560 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.163047 | 0.788 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.157898 | 0.802 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.163047 | 0.788 |
| R-HSA-376172 | DSCAM interactions | 0.057179 | 1.243 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.070957 | 1.149 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.111101 | 0.954 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.042259 | 1.374 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.209904 | 0.678 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.266021 | 0.575 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.276758 | 0.558 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.077377 | 1.111 |
| R-HSA-191859 | snRNP Assembly | 0.077377 | 1.111 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.082784 | 1.082 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.287340 | 0.542 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.318167 | 0.497 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.357215 | 0.447 |
| R-HSA-420029 | Tight junction interactions | 0.366623 | 0.436 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.209784 | 0.678 |
| R-HSA-9843745 | Adipogenesis | 0.172773 | 0.763 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.079951 | 1.097 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.099220 | 1.003 |
| R-HSA-1500620 | Meiosis | 0.049750 | 1.303 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.042259 | 1.374 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.334704 | 0.475 |
| R-HSA-195721 | Signaling by WNT | 0.327567 | 0.485 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.049349 | 1.307 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.161951 | 0.791 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.226635 | 0.645 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.327761 | 0.484 |
| R-HSA-68882 | Mitotic Anaphase | 0.268803 | 0.571 |
| R-HSA-177929 | Signaling by EGFR | 0.069572 | 1.158 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.063657 | 1.196 |
| R-HSA-6806834 | Signaling by MET | 0.042151 | 1.375 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.072874 | 1.137 |
| R-HSA-3928664 | Ephrin signaling | 0.287340 | 0.542 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.271590 | 0.566 |
| R-HSA-3214847 | HATs acetylate histones | 0.080783 | 1.093 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.318627 | 0.497 |
| R-HSA-73894 | DNA Repair | 0.199964 | 0.699 |
| R-HSA-69242 | S Phase | 0.229730 | 0.639 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.161951 | 0.791 |
| R-HSA-425381 | Bicarbonate transporters | 0.186279 | 0.730 |
| R-HSA-428540 | Activation of RAC1 | 0.198178 | 0.703 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.198178 | 0.703 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.034693 | 1.460 |
| R-HSA-69109 | Leading Strand Synthesis | 0.209904 | 0.678 |
| R-HSA-69091 | Polymerase switching | 0.209904 | 0.678 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.221459 | 0.655 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.221459 | 0.655 |
| R-HSA-68886 | M Phase | 0.076690 | 1.115 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.261402 | 0.583 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.345361 | 0.462 |
| R-HSA-170968 | Frs2-mediated activation | 0.221459 | 0.655 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.144575 | 0.840 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.157898 | 0.802 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.159545 | 0.797 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.340039 | 0.468 |
| R-HSA-202403 | TCR signaling | 0.267982 | 0.572 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.111101 | 0.954 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 0.111101 | 0.954 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.111101 | 0.954 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.161951 | 0.791 |
| R-HSA-111458 | Formation of apoptosome | 0.174204 | 0.759 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.046383 | 1.334 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.232846 | 0.633 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.287340 | 0.542 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.115215 | 0.938 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.366623 | 0.436 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.366623 | 0.436 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.359723 | 0.444 |
| R-HSA-186712 | Regulation of beta-cell development | 0.077377 | 1.111 |
| R-HSA-69306 | DNA Replication | 0.245450 | 0.610 |
| R-HSA-68875 | Mitotic Prophase | 0.049435 | 1.306 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.174204 | 0.759 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.198178 | 0.703 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.209904 | 0.678 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.209904 | 0.678 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.221459 | 0.655 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.232846 | 0.633 |
| R-HSA-975577 | N-Glycan antennae elongation | 0.255124 | 0.593 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.276758 | 0.558 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.276758 | 0.558 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.205154 | 0.688 |
| R-HSA-109704 | PI3K Cascade | 0.210505 | 0.677 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.366623 | 0.436 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.260092 | 0.585 |
| R-HSA-4086400 | PCP/CE pathway | 0.361241 | 0.442 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.077088 | 1.113 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.072132 | 1.142 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.080060 | 1.097 |
| R-HSA-4839726 | Chromatin organization | 0.104695 | 0.980 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.054710 | 1.262 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.137640 | 0.861 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.276758 | 0.558 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.080060 | 1.097 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.080060 | 1.097 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.080060 | 1.097 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.080060 | 1.097 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.085547 | 1.068 |
| R-HSA-392517 | Rap1 signalling | 0.297767 | 0.526 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.087064 | 1.060 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 0.347667 | 0.459 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.242850 | 0.615 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.083601 | 1.078 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.226721 | 0.645 |
| R-HSA-9758941 | Gastrulation | 0.232854 | 0.633 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.215870 | 0.666 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.318167 | 0.497 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.318167 | 0.497 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.089290 | 1.049 |
| R-HSA-216083 | Integrin cell surface interactions | 0.361241 | 0.442 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.275899 | 0.559 |
| R-HSA-186763 | Downstream signal transduction | 0.103839 | 0.984 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.297767 | 0.526 |
| R-HSA-9839394 | TGFBR3 expression | 0.366623 | 0.436 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.329357 | 0.482 |
| R-HSA-162582 | Signal Transduction | 0.174832 | 0.757 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.329357 | 0.482 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.056834 | 1.245 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.186279 | 0.730 |
| R-HSA-1187000 | Fertilization | 0.366623 | 0.436 |
| R-HSA-112399 | IRS-mediated signalling | 0.248267 | 0.605 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.264538 | 0.578 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.161475 | 0.792 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.213578 | 0.670 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.329357 | 0.482 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.128032 | 0.893 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.295787 | 0.529 |
| R-HSA-1483255 | PI Metabolism | 0.232758 | 0.633 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.149517 | 0.825 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.244067 | 0.612 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.094067 | 1.027 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.121561 | 0.915 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.080783 | 1.093 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.307765 | 0.512 |
| R-HSA-162906 | HIV Infection | 0.159293 | 0.798 |
| R-HSA-194138 | Signaling by VEGF | 0.339760 | 0.469 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.122864 | 0.911 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.297767 | 0.526 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.221247 | 0.655 |
| R-HSA-70171 | Glycolysis | 0.225047 | 0.648 |
| R-HSA-162587 | HIV Life Cycle | 0.118060 | 0.928 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.211224 | 0.675 |
| R-HSA-157118 | Signaling by NOTCH | 0.091718 | 1.038 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.366623 | 0.436 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.269964 | 0.569 |
| R-HSA-166520 | Signaling by NTRKs | 0.100314 | 0.999 |
| R-HSA-8848021 | Signaling by PTK6 | 0.280812 | 0.552 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.280812 | 0.552 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.287340 | 0.542 |
| R-HSA-3371556 | Cellular response to heat stress | 0.139753 | 0.855 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.319846 | 0.495 |
| R-HSA-8983711 | OAS antiviral response | 0.209904 | 0.678 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.244067 | 0.612 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.297767 | 0.526 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.308042 | 0.511 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.361241 | 0.442 |
| R-HSA-186797 | Signaling by PDGF | 0.275389 | 0.560 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.124781 | 0.904 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.285958 | 0.544 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.286231 | 0.543 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.334704 | 0.475 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.347667 | 0.459 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.108515 | 0.965 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.168226 | 0.774 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.291647 | 0.535 |
| R-HSA-73887 | Death Receptor Signaling | 0.248623 | 0.604 |
| R-HSA-70326 | Glucose metabolism | 0.303770 | 0.517 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.291801 | 0.535 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.286231 | 0.543 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.052987 | 1.276 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.340039 | 0.468 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.347667 | 0.459 |
| R-HSA-109581 | Apoptosis | 0.274305 | 0.562 |
| R-HSA-75153 | Apoptotic execution phase | 0.189201 | 0.723 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.357300 | 0.447 |
| R-HSA-2028269 | Signaling by Hippo | 0.276758 | 0.558 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.287340 | 0.542 |
| R-HSA-5619102 | SLC transporter disorders | 0.290580 | 0.537 |
| R-HSA-1442490 | Collagen degradation | 0.269964 | 0.569 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.337978 | 0.471 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.248623 | 0.604 |
| R-HSA-211000 | Gene Silencing by RNA | 0.256159 | 0.591 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.267839 | 0.572 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.371662 | 0.430 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.371748 | 0.430 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.373216 | 0.428 |
| R-HSA-525793 | Myogenesis | 0.375895 | 0.425 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.375895 | 0.425 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.375895 | 0.425 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.375895 | 0.425 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.375895 | 0.425 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.375895 | 0.425 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.375895 | 0.425 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.375895 | 0.425 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.376531 | 0.424 |
| R-HSA-5688426 | Deubiquitination | 0.380494 | 0.420 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.385032 | 0.415 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.385032 | 0.415 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.385032 | 0.415 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.385032 | 0.415 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.392551 | 0.406 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.392551 | 0.406 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.392579 | 0.406 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.394035 | 0.404 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.394035 | 0.404 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.394035 | 0.404 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.394035 | 0.404 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.402836 | 0.395 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.402836 | 0.395 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.402907 | 0.395 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.402907 | 0.395 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.402907 | 0.395 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.402907 | 0.395 |
| R-HSA-1280218 | Adaptive Immune System | 0.403619 | 0.394 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.403668 | 0.394 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.411649 | 0.385 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.411649 | 0.385 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.411649 | 0.385 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.411649 | 0.385 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.411649 | 0.385 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.412846 | 0.384 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.412846 | 0.384 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.420265 | 0.376 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.420265 | 0.376 |
| R-HSA-5357801 | Programmed Cell Death | 0.422682 | 0.374 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.424385 | 0.372 |
| R-HSA-202424 | Downstream TCR signaling | 0.428179 | 0.368 |
| R-HSA-73884 | Base Excision Repair | 0.428179 | 0.368 |
| R-HSA-69190 | DNA strand elongation | 0.428754 | 0.368 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.428754 | 0.368 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.437120 | 0.359 |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 0.437120 | 0.359 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.437120 | 0.359 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.437120 | 0.359 |
| R-HSA-354192 | Integrin signaling | 0.437120 | 0.359 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.442117 | 0.354 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.443112 | 0.353 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.443112 | 0.353 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.445364 | 0.351 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.448043 | 0.349 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.448043 | 0.349 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.452948 | 0.344 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.453487 | 0.343 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.453487 | 0.343 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.453487 | 0.343 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.453487 | 0.343 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.453487 | 0.343 |
| R-HSA-190861 | Gap junction assembly | 0.453487 | 0.343 |
| R-HSA-422475 | Axon guidance | 0.454261 | 0.343 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.461492 | 0.336 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.461492 | 0.336 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.461492 | 0.336 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.461492 | 0.336 |
| R-HSA-169911 | Regulation of Apoptosis | 0.461492 | 0.336 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.461492 | 0.336 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.468724 | 0.329 |
| R-HSA-1989781 | PPARA activates gene expression | 0.468724 | 0.329 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.469380 | 0.328 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.469380 | 0.328 |
| R-HSA-8853659 | RET signaling | 0.469380 | 0.328 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.469380 | 0.328 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.469380 | 0.328 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.472319 | 0.326 |
| R-HSA-9610379 | HCMV Late Events | 0.476223 | 0.322 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.476223 | 0.322 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.477098 | 0.321 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.477098 | 0.321 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.477098 | 0.321 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.477154 | 0.321 |
| R-HSA-4641258 | Degradation of DVL | 0.477154 | 0.321 |
| R-HSA-4641257 | Degradation of AXIN | 0.477154 | 0.321 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.477154 | 0.321 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.477154 | 0.321 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.477154 | 0.321 |
| R-HSA-8948216 | Collagen chain trimerization | 0.477154 | 0.321 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.477943 | 0.321 |
| R-HSA-9931953 | Biofilm formation | 0.484813 | 0.314 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.484813 | 0.314 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.487380 | 0.312 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.492361 | 0.308 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.492361 | 0.308 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.492361 | 0.308 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.492361 | 0.308 |
| R-HSA-69541 | Stabilization of p53 | 0.492361 | 0.308 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.492361 | 0.308 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.496425 | 0.304 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.497463 | 0.303 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.499799 | 0.301 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.499799 | 0.301 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.499799 | 0.301 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.499799 | 0.301 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 0.499799 | 0.301 |
| R-HSA-202433 | Generation of second messenger molecules | 0.499799 | 0.301 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.499799 | 0.301 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.499799 | 0.301 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.507129 | 0.295 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.507129 | 0.295 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.507129 | 0.295 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.507129 | 0.295 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.507129 | 0.295 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.507129 | 0.295 |
| R-HSA-9833110 | RSV-host interactions | 0.509797 | 0.293 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.514351 | 0.289 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.514351 | 0.289 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.514351 | 0.289 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.514351 | 0.289 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.514351 | 0.289 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.514359 | 0.289 |
| R-HSA-418346 | Platelet homeostasis | 0.518893 | 0.285 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.523398 | 0.281 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.523398 | 0.281 |
| R-HSA-72306 | tRNA processing | 0.527268 | 0.278 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.527875 | 0.277 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.527875 | 0.277 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.528481 | 0.277 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.528481 | 0.277 |
| R-HSA-9675108 | Nervous system development | 0.529974 | 0.276 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.532324 | 0.274 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.532324 | 0.274 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.532324 | 0.274 |
| R-HSA-9907900 | Proteasome assembly | 0.535392 | 0.271 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.535392 | 0.271 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.535392 | 0.271 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.535392 | 0.271 |
| R-HSA-190828 | Gap junction trafficking | 0.535392 | 0.271 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.537848 | 0.269 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.537848 | 0.269 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.537848 | 0.269 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.541345 | 0.267 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.542202 | 0.266 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.542202 | 0.266 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.542202 | 0.266 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.542202 | 0.266 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.542202 | 0.266 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.542202 | 0.266 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.542202 | 0.266 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.542202 | 0.266 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.542202 | 0.266 |
| R-HSA-9824272 | Somitogenesis | 0.542202 | 0.266 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.542202 | 0.266 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.542202 | 0.266 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.545499 | 0.263 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.545499 | 0.263 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.548913 | 0.260 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.548913 | 0.260 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.548913 | 0.260 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.549833 | 0.260 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.555525 | 0.255 |
| R-HSA-437239 | Recycling pathway of L1 | 0.555525 | 0.255 |
| R-HSA-168255 | Influenza Infection | 0.558599 | 0.253 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.562041 | 0.250 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.562041 | 0.250 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.562041 | 0.250 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 0.568462 | 0.245 |
| R-HSA-73893 | DNA Damage Bypass | 0.568462 | 0.245 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.568462 | 0.245 |
| R-HSA-9766229 | Degradation of CDH1 | 0.568462 | 0.245 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.568462 | 0.245 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.568462 | 0.245 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.568462 | 0.245 |
| R-HSA-373760 | L1CAM interactions | 0.571066 | 0.243 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.574789 | 0.240 |
| R-HSA-912446 | Meiotic recombination | 0.581024 | 0.236 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.581024 | 0.236 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.583455 | 0.234 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.583455 | 0.234 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.583455 | 0.234 |
| R-HSA-72187 | mRNA 3'-end processing | 0.587168 | 0.231 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.587168 | 0.231 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.587168 | 0.231 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.587168 | 0.231 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.587168 | 0.231 |
| R-HSA-1474244 | Extracellular matrix organization | 0.590303 | 0.229 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.591568 | 0.228 |
| R-HSA-983712 | Ion channel transport | 0.591915 | 0.228 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.593222 | 0.227 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.593222 | 0.227 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.595580 | 0.225 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.595580 | 0.225 |
| R-HSA-72649 | Translation initiation complex formation | 0.599188 | 0.222 |
| R-HSA-68877 | Mitotic Prometaphase | 0.604782 | 0.218 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.610859 | 0.214 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.610859 | 0.214 |
| R-HSA-5578775 | Ion homeostasis | 0.610859 | 0.214 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.610859 | 0.214 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.610859 | 0.214 |
| R-HSA-75893 | TNF signaling | 0.610859 | 0.214 |
| R-HSA-9609690 | HCMV Early Events | 0.614255 | 0.212 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.615199 | 0.211 |
| R-HSA-5621480 | Dectin-2 family | 0.616567 | 0.210 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.616567 | 0.210 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.622192 | 0.206 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.622192 | 0.206 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.622192 | 0.206 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.627734 | 0.202 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.627734 | 0.202 |
| R-HSA-74160 | Gene expression (Transcription) | 0.629644 | 0.201 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.632741 | 0.199 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.633196 | 0.198 |
| R-HSA-351202 | Metabolism of polyamines | 0.633196 | 0.198 |
| R-HSA-379724 | tRNA Aminoacylation | 0.633196 | 0.198 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.638577 | 0.195 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.638577 | 0.195 |
| R-HSA-450294 | MAP kinase activation | 0.638577 | 0.195 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.638577 | 0.195 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.638577 | 0.195 |
| R-HSA-112043 | PLC beta mediated events | 0.638577 | 0.195 |
| R-HSA-446728 | Cell junction organization | 0.640355 | 0.194 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.642947 | 0.192 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.643880 | 0.191 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.643880 | 0.191 |
| R-HSA-9707616 | Heme signaling | 0.643880 | 0.191 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.643880 | 0.191 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.648094 | 0.188 |
| R-HSA-9658195 | Leishmania infection | 0.648094 | 0.188 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.649106 | 0.188 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.649106 | 0.188 |
| R-HSA-6799198 | Complex I biogenesis | 0.649106 | 0.188 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.649106 | 0.188 |
| R-HSA-373755 | Semaphorin interactions | 0.649106 | 0.188 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.649106 | 0.188 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.654255 | 0.184 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.654255 | 0.184 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.659298 | 0.181 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.659298 | 0.181 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.662785 | 0.179 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.664329 | 0.178 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.664329 | 0.178 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.666243 | 0.176 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.669256 | 0.174 |
| R-HSA-112040 | G-protein mediated events | 0.669256 | 0.174 |
| R-HSA-6807070 | PTEN Regulation | 0.669673 | 0.174 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.673074 | 0.172 |
| R-HSA-9664407 | Parasite infection | 0.673074 | 0.172 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.673074 | 0.172 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.674111 | 0.171 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.674111 | 0.171 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.674111 | 0.171 |
| R-HSA-167172 | Transcription of the HIV genome | 0.674111 | 0.171 |
| R-HSA-1266738 | Developmental Biology | 0.680600 | 0.167 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.683608 | 0.165 |
| R-HSA-448424 | Interleukin-17 signaling | 0.683608 | 0.165 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.683608 | 0.165 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.688253 | 0.162 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.688253 | 0.162 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.688253 | 0.162 |
| R-HSA-3000178 | ECM proteoglycans | 0.688253 | 0.162 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.689657 | 0.161 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.692830 | 0.159 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.692830 | 0.159 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.697340 | 0.157 |
| R-HSA-4086398 | Ca2+ pathway | 0.697340 | 0.157 |
| R-HSA-9749641 | Aspirin ADME | 0.697340 | 0.157 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.699272 | 0.155 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.703066 | 0.153 |
| R-HSA-380287 | Centrosome maturation | 0.706164 | 0.151 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.706164 | 0.151 |
| R-HSA-8852135 | Protein ubiquitination | 0.706164 | 0.151 |
| R-HSA-6798695 | Neutrophil degranulation | 0.707629 | 0.150 |
| R-HSA-5689603 | UCH proteinases | 0.710479 | 0.148 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.710778 | 0.148 |
| R-HSA-913531 | Interferon Signaling | 0.711016 | 0.148 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.714749 | 0.146 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.714749 | 0.146 |
| R-HSA-8953854 | Metabolism of RNA | 0.718913 | 0.143 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.718921 | 0.143 |
| R-HSA-5619084 | ABC transporter disorders | 0.718921 | 0.143 |
| R-HSA-1643685 | Disease | 0.720423 | 0.142 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.727118 | 0.138 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.727118 | 0.138 |
| R-HSA-1500931 | Cell-Cell communication | 0.730133 | 0.137 |
| R-HSA-8939211 | ESR-mediated signaling | 0.730592 | 0.136 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.731126 | 0.136 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.735076 | 0.134 |
| R-HSA-449147 | Signaling by Interleukins | 0.737448 | 0.132 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.738969 | 0.131 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.742804 | 0.129 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.743581 | 0.129 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.746583 | 0.127 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.750307 | 0.125 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.753976 | 0.123 |
| R-HSA-9609646 | HCMV Infection | 0.760506 | 0.119 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.761155 | 0.119 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.764665 | 0.117 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.768125 | 0.115 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.768125 | 0.115 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.768125 | 0.115 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.772627 | 0.112 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.773383 | 0.112 |
| R-HSA-2029481 | FCGR activation | 0.781463 | 0.107 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.782445 | 0.107 |
| R-HSA-1474290 | Collagen formation | 0.784676 | 0.105 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.787842 | 0.104 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.790962 | 0.102 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.790962 | 0.102 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.793627 | 0.100 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.794036 | 0.100 |
| R-HSA-1296071 | Potassium Channels | 0.794036 | 0.100 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.800050 | 0.097 |
| R-HSA-190236 | Signaling by FGFR | 0.800050 | 0.097 |
| R-HSA-422356 | Regulation of insulin secretion | 0.800050 | 0.097 |
| R-HSA-3781865 | Diseases of glycosylation | 0.800902 | 0.096 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.802991 | 0.095 |
| R-HSA-69275 | G2/M Transition | 0.805301 | 0.094 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.805889 | 0.094 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.805889 | 0.094 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.808654 | 0.092 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.808745 | 0.092 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.808745 | 0.092 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.809613 | 0.092 |
| R-HSA-5617833 | Cilium Assembly | 0.813841 | 0.089 |
| R-HSA-597592 | Post-translational protein modification | 0.814101 | 0.089 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.817063 | 0.088 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.817063 | 0.088 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.817063 | 0.088 |
| R-HSA-111885 | Opioid Signalling | 0.817063 | 0.088 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.819755 | 0.086 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.819755 | 0.086 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.822407 | 0.085 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.830134 | 0.081 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.830134 | 0.081 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.830134 | 0.081 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.833748 | 0.079 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.835098 | 0.078 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.835098 | 0.078 |
| R-HSA-428157 | Sphingolipid metabolism | 0.835629 | 0.078 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.839917 | 0.076 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.841184 | 0.075 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.842274 | 0.075 |
| R-HSA-1483257 | Phospholipid metabolism | 0.843863 | 0.074 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.844596 | 0.073 |
| R-HSA-212436 | Generic Transcription Pathway | 0.846152 | 0.073 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.846885 | 0.072 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.851361 | 0.070 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.851361 | 0.070 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.853550 | 0.069 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.853550 | 0.069 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.855707 | 0.068 |
| R-HSA-397014 | Muscle contraction | 0.856757 | 0.067 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.864023 | 0.063 |
| R-HSA-199991 | Membrane Trafficking | 0.865282 | 0.063 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.869946 | 0.061 |
| R-HSA-8951664 | Neddylation | 0.870948 | 0.060 |
| R-HSA-69206 | G1/S Transition | 0.873750 | 0.059 |
| R-HSA-114608 | Platelet degranulation | 0.877444 | 0.057 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.878365 | 0.056 |
| R-HSA-5576891 | Cardiac conduction | 0.886215 | 0.052 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.886215 | 0.052 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.889546 | 0.051 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.893037 | 0.049 |
| R-HSA-163685 | Integration of energy metabolism | 0.895919 | 0.048 |
| R-HSA-5173105 | O-linked glycosylation | 0.897454 | 0.047 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.898966 | 0.046 |
| R-HSA-168249 | Innate Immune System | 0.900096 | 0.046 |
| R-HSA-1632852 | Macroautophagy | 0.903372 | 0.044 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.903372 | 0.044 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.907587 | 0.042 |
| R-HSA-421270 | Cell-cell junction organization | 0.909438 | 0.041 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.911618 | 0.040 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.917951 | 0.037 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.919163 | 0.037 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.921615 | 0.035 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.922180 | 0.035 |
| R-HSA-416476 | G alpha (q) signalling events | 0.922539 | 0.035 |
| R-HSA-9612973 | Autophagy | 0.923833 | 0.034 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.924958 | 0.034 |
| R-HSA-9711097 | Cellular response to starvation | 0.926066 | 0.033 |
| R-HSA-877300 | Interferon gamma signaling | 0.927158 | 0.033 |
| R-HSA-168256 | Immune System | 0.933428 | 0.030 |
| R-HSA-418555 | G alpha (s) signalling events | 0.939975 | 0.027 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.941737 | 0.026 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.941737 | 0.026 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.942413 | 0.026 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.943447 | 0.025 |
| R-HSA-611105 | Respiratory electron transport | 0.945919 | 0.024 |
| R-HSA-2559583 | Cellular Senescence | 0.947507 | 0.023 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.953408 | 0.021 |
| R-HSA-109582 | Hemostasis | 0.954158 | 0.020 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.956755 | 0.019 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.957396 | 0.019 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.958648 | 0.018 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.961043 | 0.017 |
| R-HSA-72766 | Translation | 0.962585 | 0.017 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.962705 | 0.017 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.962749 | 0.016 |
| R-HSA-72172 | mRNA Splicing | 0.963844 | 0.016 |
| R-HSA-6805567 | Keratinization | 0.964908 | 0.016 |
| R-HSA-9748784 | Drug ADME | 0.970665 | 0.013 |
| R-HSA-418990 | Adherens junctions interactions | 0.970665 | 0.013 |
| R-HSA-9679506 | SARS-CoV Infections | 0.971472 | 0.013 |
| R-HSA-2262752 | Cellular responses to stress | 0.971792 | 0.012 |
| R-HSA-112316 | Neuronal System | 0.975986 | 0.011 |
| R-HSA-72312 | rRNA processing | 0.976203 | 0.010 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.979598 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 0.981989 | 0.008 |
| R-HSA-5663205 | Infectious disease | 0.984343 | 0.007 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.985639 | 0.006 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.986117 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 0.988954 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 0.990296 | 0.004 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.993920 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.994325 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.995362 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.996703 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.997568 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997946 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.998312 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998905 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999901 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999932 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.831 | 0.213 | 2 | 0.885 |
CDC7 |
0.824 | 0.211 | 1 | 0.339 |
BMPR1B |
0.822 | 0.393 | 1 | 0.466 |
CLK3 |
0.817 | 0.091 | 1 | 0.225 |
GRK1 |
0.814 | 0.185 | -2 | 0.794 |
GRK6 |
0.812 | 0.260 | 1 | 0.343 |
NDR2 |
0.812 | 0.078 | -3 | 0.840 |
MTOR |
0.810 | -0.027 | 1 | 0.199 |
RSK2 |
0.810 | 0.108 | -3 | 0.760 |
IKKB |
0.809 | -0.017 | -2 | 0.742 |
PIM3 |
0.809 | 0.066 | -3 | 0.826 |
TGFBR1 |
0.808 | 0.257 | -2 | 0.833 |
DSTYK |
0.808 | 0.046 | 2 | 0.883 |
CAMK2G |
0.807 | 0.060 | 2 | 0.841 |
CAMK2B |
0.807 | 0.141 | 2 | 0.827 |
BMPR1A |
0.806 | 0.312 | 1 | 0.445 |
MOS |
0.806 | 0.078 | 1 | 0.267 |
GRK7 |
0.806 | 0.176 | 1 | 0.299 |
TBK1 |
0.804 | -0.102 | 1 | 0.178 |
GRK5 |
0.804 | 0.147 | -3 | 0.885 |
CK2A2 |
0.803 | 0.266 | 1 | 0.415 |
IKKA |
0.803 | 0.038 | -2 | 0.732 |
RAF1 |
0.803 | -0.012 | 1 | 0.243 |
ALK4 |
0.803 | 0.228 | -2 | 0.860 |
MAPKAPK2 |
0.802 | 0.075 | -3 | 0.716 |
LATS2 |
0.802 | 0.049 | -5 | 0.765 |
SKMLCK |
0.801 | 0.108 | -2 | 0.846 |
GCN2 |
0.801 | -0.100 | 2 | 0.799 |
CAMK1B |
0.801 | 0.035 | -3 | 0.857 |
DRAK1 |
0.801 | 0.359 | 1 | 0.468 |
PRPK |
0.801 | -0.057 | -1 | 0.856 |
KIS |
0.801 | -0.017 | 1 | 0.158 |
ACVR2A |
0.801 | 0.290 | -2 | 0.810 |
PLK1 |
0.800 | 0.201 | -2 | 0.813 |
IKKE |
0.800 | -0.114 | 1 | 0.178 |
JNK2 |
0.800 | 0.012 | 1 | 0.177 |
CDK1 |
0.800 | 0.020 | 1 | 0.214 |
PDHK4 |
0.800 | -0.104 | 1 | 0.223 |
CAMK2A |
0.799 | 0.129 | 2 | 0.831 |
CAMK2D |
0.799 | 0.038 | -3 | 0.846 |
CK2A1 |
0.799 | 0.276 | 1 | 0.436 |
P90RSK |
0.799 | 0.060 | -3 | 0.756 |
ACVR2B |
0.799 | 0.280 | -2 | 0.819 |
ATR |
0.799 | -0.045 | 1 | 0.215 |
NLK |
0.799 | -0.031 | 1 | 0.220 |
GRK2 |
0.798 | 0.289 | -2 | 0.719 |
ERK5 |
0.798 | -0.042 | 1 | 0.202 |
NDR1 |
0.798 | 0.014 | -3 | 0.830 |
TGFBR2 |
0.797 | 0.053 | -2 | 0.821 |
RSK4 |
0.796 | 0.113 | -3 | 0.725 |
BMPR2 |
0.796 | -0.036 | -2 | 0.886 |
ULK2 |
0.796 | -0.116 | 2 | 0.778 |
PIM1 |
0.795 | 0.038 | -3 | 0.771 |
CDK8 |
0.795 | -0.040 | 1 | 0.172 |
HUNK |
0.795 | 0.008 | 2 | 0.811 |
ALK2 |
0.795 | 0.189 | -2 | 0.841 |
MST4 |
0.795 | -0.014 | 2 | 0.827 |
PRKD1 |
0.795 | -0.009 | -3 | 0.822 |
PKN3 |
0.795 | -0.023 | -3 | 0.816 |
DLK |
0.794 | 0.111 | 1 | 0.282 |
JNK3 |
0.794 | -0.004 | 1 | 0.171 |
LATS1 |
0.793 | 0.100 | -3 | 0.860 |
WNK1 |
0.793 | -0.048 | -2 | 0.867 |
CDKL1 |
0.793 | -0.010 | -3 | 0.793 |
GRK4 |
0.792 | 0.040 | -2 | 0.830 |
DAPK2 |
0.792 | 0.093 | -3 | 0.869 |
CDK19 |
0.792 | -0.039 | 1 | 0.164 |
NEK6 |
0.792 | -0.062 | -2 | 0.857 |
NEK7 |
0.792 | -0.093 | -3 | 0.854 |
PKN2 |
0.791 | 0.003 | -3 | 0.838 |
P38G |
0.791 | -0.014 | 1 | 0.169 |
RIPK3 |
0.791 | -0.057 | 3 | 0.691 |
MAPKAPK3 |
0.791 | 0.005 | -3 | 0.768 |
ULK1 |
0.791 | -0.078 | -3 | 0.819 |
FAM20C |
0.791 | 0.038 | 2 | 0.645 |
NIK |
0.791 | -0.033 | -3 | 0.880 |
PKACG |
0.791 | 0.006 | -2 | 0.738 |
PDHK1 |
0.790 | -0.178 | 1 | 0.192 |
CDK18 |
0.790 | -0.021 | 1 | 0.162 |
MSK1 |
0.790 | 0.068 | -3 | 0.738 |
RSK3 |
0.790 | 0.008 | -3 | 0.743 |
CLK2 |
0.790 | 0.076 | -3 | 0.723 |
DYRK2 |
0.790 | -0.027 | 1 | 0.169 |
MARK4 |
0.790 | -0.018 | 4 | 0.786 |
HIPK4 |
0.790 | -0.042 | 1 | 0.171 |
PRKD2 |
0.789 | 0.001 | -3 | 0.753 |
MLK1 |
0.789 | -0.068 | 2 | 0.798 |
ATM |
0.789 | -0.038 | 1 | 0.204 |
CDK17 |
0.789 | -0.023 | 1 | 0.169 |
CAMLCK |
0.789 | 0.008 | -2 | 0.842 |
P70S6KB |
0.789 | 0.022 | -3 | 0.786 |
PKCD |
0.789 | -0.014 | 2 | 0.768 |
SRPK1 |
0.789 | -0.017 | -3 | 0.733 |
BCKDK |
0.789 | -0.098 | -1 | 0.830 |
CDK3 |
0.789 | 0.004 | 1 | 0.173 |
CHAK2 |
0.788 | -0.048 | -1 | 0.883 |
DNAPK |
0.788 | -0.037 | 1 | 0.151 |
AMPKA1 |
0.788 | -0.023 | -3 | 0.851 |
NUAK2 |
0.787 | -0.005 | -3 | 0.830 |
GRK3 |
0.787 | 0.234 | -2 | 0.680 |
P38B |
0.787 | -0.017 | 1 | 0.165 |
PASK |
0.787 | 0.221 | -3 | 0.854 |
MSK2 |
0.787 | 0.012 | -3 | 0.733 |
ICK |
0.786 | -0.019 | -3 | 0.833 |
AURC |
0.786 | 0.036 | -2 | 0.652 |
PRKX |
0.786 | 0.074 | -3 | 0.660 |
CDK7 |
0.785 | -0.050 | 1 | 0.177 |
CDKL5 |
0.785 | -0.037 | -3 | 0.788 |
PLK3 |
0.785 | 0.031 | 2 | 0.798 |
TSSK2 |
0.784 | 0.005 | -5 | 0.825 |
CAMK4 |
0.784 | -0.032 | -3 | 0.820 |
MASTL |
0.784 | -0.106 | -2 | 0.810 |
CDK13 |
0.783 | -0.053 | 1 | 0.163 |
CDK2 |
0.783 | 0.006 | 1 | 0.246 |
CLK4 |
0.783 | 0.012 | -3 | 0.750 |
ERK1 |
0.782 | -0.038 | 1 | 0.155 |
PKACB |
0.782 | 0.037 | -2 | 0.670 |
WNK3 |
0.782 | -0.175 | 1 | 0.179 |
ANKRD3 |
0.782 | -0.076 | 1 | 0.228 |
DYRK4 |
0.782 | -0.013 | 1 | 0.161 |
PAK1 |
0.782 | -0.023 | -2 | 0.774 |
CDK5 |
0.782 | -0.028 | 1 | 0.182 |
RIPK1 |
0.781 | -0.115 | 1 | 0.208 |
HIPK2 |
0.781 | -0.022 | 1 | 0.144 |
P38D |
0.781 | -0.023 | 1 | 0.126 |
TSSK1 |
0.781 | -0.018 | -3 | 0.870 |
AMPKA2 |
0.781 | -0.032 | -3 | 0.815 |
TTBK2 |
0.781 | -0.118 | 2 | 0.699 |
P38A |
0.781 | -0.035 | 1 | 0.172 |
MEK1 |
0.780 | 0.046 | 2 | 0.850 |
CDK16 |
0.780 | -0.014 | 1 | 0.160 |
MLK3 |
0.780 | -0.030 | 2 | 0.719 |
NEK9 |
0.780 | -0.138 | 2 | 0.815 |
AURA |
0.780 | 0.041 | -2 | 0.624 |
ERK2 |
0.780 | -0.044 | 1 | 0.167 |
YSK4 |
0.779 | -0.062 | 1 | 0.214 |
NIM1 |
0.779 | -0.072 | 3 | 0.744 |
SRPK2 |
0.778 | -0.019 | -3 | 0.654 |
CLK1 |
0.778 | 0.002 | -3 | 0.722 |
JNK1 |
0.778 | -0.004 | 1 | 0.186 |
MYLK4 |
0.778 | 0.050 | -2 | 0.761 |
BRSK1 |
0.777 | 0.031 | -3 | 0.775 |
PKCB |
0.777 | -0.018 | 2 | 0.711 |
MLK2 |
0.777 | -0.128 | 2 | 0.806 |
CDK14 |
0.777 | -0.023 | 1 | 0.178 |
CDK12 |
0.777 | -0.055 | 1 | 0.158 |
PKR |
0.776 | -0.078 | 1 | 0.191 |
MNK2 |
0.776 | -0.030 | -2 | 0.779 |
PKCG |
0.776 | -0.019 | 2 | 0.715 |
QSK |
0.776 | -0.010 | 4 | 0.758 |
TLK2 |
0.776 | -0.063 | 1 | 0.188 |
AURB |
0.775 | 0.006 | -2 | 0.651 |
PAK3 |
0.775 | -0.074 | -2 | 0.771 |
SMG1 |
0.775 | -0.080 | 1 | 0.177 |
MEKK3 |
0.775 | 0.004 | 1 | 0.247 |
MARK3 |
0.775 | 0.027 | 4 | 0.714 |
MLK4 |
0.774 | -0.024 | 2 | 0.709 |
HIPK1 |
0.774 | -0.028 | 1 | 0.168 |
PAK2 |
0.774 | -0.047 | -2 | 0.762 |
DYRK1B |
0.774 | -0.025 | 1 | 0.173 |
PAK6 |
0.774 | -0.024 | -2 | 0.698 |
PLK4 |
0.773 | -0.077 | 2 | 0.653 |
CDK9 |
0.773 | -0.068 | 1 | 0.162 |
PKCA |
0.773 | -0.032 | 2 | 0.698 |
SGK3 |
0.773 | -0.007 | -3 | 0.754 |
QIK |
0.773 | -0.058 | -3 | 0.840 |
MNK1 |
0.773 | -0.022 | -2 | 0.791 |
MELK |
0.773 | -0.061 | -3 | 0.799 |
IRE1 |
0.772 | -0.142 | 1 | 0.164 |
MARK2 |
0.772 | 0.008 | 4 | 0.680 |
CDK10 |
0.771 | -0.023 | 1 | 0.177 |
CHK1 |
0.771 | -0.021 | -3 | 0.818 |
MST3 |
0.771 | 0.032 | 2 | 0.813 |
ZAK |
0.771 | -0.056 | 1 | 0.223 |
DCAMKL1 |
0.771 | -0.013 | -3 | 0.766 |
CK1E |
0.770 | 0.057 | -3 | 0.607 |
SRPK3 |
0.770 | -0.038 | -3 | 0.706 |
PKG2 |
0.770 | -0.009 | -2 | 0.671 |
BRAF |
0.770 | -0.002 | -4 | 0.829 |
MARK1 |
0.770 | 0.021 | 4 | 0.735 |
PKCH |
0.770 | -0.046 | 2 | 0.698 |
CAMK1G |
0.769 | -0.021 | -3 | 0.749 |
NUAK1 |
0.769 | -0.063 | -3 | 0.773 |
PRKD3 |
0.769 | -0.046 | -3 | 0.722 |
NEK2 |
0.769 | -0.133 | 2 | 0.786 |
BRSK2 |
0.769 | -0.061 | -3 | 0.811 |
AKT2 |
0.769 | -0.003 | -3 | 0.667 |
VRK2 |
0.769 | -0.202 | 1 | 0.208 |
SIK |
0.768 | -0.043 | -3 | 0.749 |
PKCZ |
0.768 | -0.081 | 2 | 0.757 |
PHKG1 |
0.768 | -0.107 | -3 | 0.823 |
GSK3A |
0.767 | 0.035 | 4 | 0.492 |
PIM2 |
0.766 | -0.005 | -3 | 0.731 |
DYRK1A |
0.766 | -0.046 | 1 | 0.167 |
IRE2 |
0.765 | -0.140 | 2 | 0.740 |
MAPKAPK5 |
0.765 | -0.082 | -3 | 0.714 |
GAK |
0.765 | 0.019 | 1 | 0.230 |
CHAK1 |
0.765 | -0.148 | 2 | 0.742 |
DAPK1 |
0.764 | 0.115 | -3 | 0.770 |
GSK3B |
0.764 | 0.023 | 4 | 0.480 |
PKACA |
0.764 | 0.013 | -2 | 0.618 |
TAO3 |
0.764 | -0.026 | 1 | 0.224 |
SMMLCK |
0.763 | 0.022 | -3 | 0.813 |
GCK |
0.763 | 0.078 | 1 | 0.272 |
DYRK3 |
0.763 | -0.039 | 1 | 0.161 |
DCAMKL2 |
0.763 | -0.034 | -3 | 0.790 |
MPSK1 |
0.763 | -0.058 | 1 | 0.152 |
CK1D |
0.762 | 0.047 | -3 | 0.564 |
MEK5 |
0.762 | -0.129 | 2 | 0.820 |
TLK1 |
0.761 | -0.109 | -2 | 0.831 |
MEKK1 |
0.761 | -0.154 | 1 | 0.189 |
PRP4 |
0.761 | -0.039 | -3 | 0.753 |
HIPK3 |
0.761 | -0.073 | 1 | 0.145 |
DAPK3 |
0.761 | 0.059 | -3 | 0.786 |
MEKK2 |
0.760 | -0.106 | 2 | 0.798 |
WNK4 |
0.760 | -0.125 | -2 | 0.864 |
NEK5 |
0.760 | -0.125 | 1 | 0.185 |
PLK2 |
0.760 | 0.027 | -3 | 0.746 |
CAMK1D |
0.760 | 0.001 | -3 | 0.657 |
PERK |
0.760 | -0.148 | -2 | 0.845 |
P70S6K |
0.759 | -0.021 | -3 | 0.697 |
CK1A2 |
0.759 | 0.048 | -3 | 0.560 |
AKT1 |
0.759 | -0.021 | -3 | 0.691 |
NEK11 |
0.758 | -0.060 | 1 | 0.240 |
CAMKK1 |
0.758 | -0.066 | -2 | 0.755 |
SNRK |
0.757 | -0.143 | 2 | 0.696 |
HRI |
0.757 | -0.192 | -2 | 0.855 |
TTBK1 |
0.756 | -0.130 | 2 | 0.620 |
CDK6 |
0.756 | -0.056 | 1 | 0.152 |
PKCT |
0.755 | -0.082 | 2 | 0.708 |
CK1G1 |
0.755 | -0.033 | -3 | 0.589 |
PAK5 |
0.755 | -0.053 | -2 | 0.632 |
IRAK4 |
0.755 | -0.157 | 1 | 0.153 |
MST2 |
0.755 | -0.025 | 1 | 0.241 |
SSTK |
0.754 | -0.058 | 4 | 0.735 |
TAK1 |
0.754 | -0.022 | 1 | 0.227 |
NEK8 |
0.754 | -0.105 | 2 | 0.799 |
HPK1 |
0.754 | 0.021 | 1 | 0.263 |
CDK4 |
0.754 | -0.058 | 1 | 0.149 |
PINK1 |
0.753 | -0.176 | 1 | 0.176 |
CAMKK2 |
0.753 | -0.069 | -2 | 0.745 |
MAK |
0.753 | -0.004 | -2 | 0.721 |
LKB1 |
0.753 | -0.088 | -3 | 0.849 |
PKCI |
0.752 | -0.064 | 2 | 0.721 |
PHKG2 |
0.751 | -0.112 | -3 | 0.790 |
PAK4 |
0.751 | -0.049 | -2 | 0.637 |
PKCE |
0.751 | -0.022 | 2 | 0.692 |
MINK |
0.750 | -0.069 | 1 | 0.206 |
PDK1 |
0.749 | -0.112 | 1 | 0.188 |
TAO2 |
0.748 | -0.113 | 2 | 0.823 |
EEF2K |
0.748 | -0.058 | 3 | 0.784 |
MAP3K15 |
0.748 | -0.106 | 1 | 0.196 |
SGK1 |
0.748 | 0.004 | -3 | 0.587 |
MRCKA |
0.748 | -0.010 | -3 | 0.742 |
ERK7 |
0.748 | -0.052 | 2 | 0.518 |
TNIK |
0.748 | -0.068 | 3 | 0.808 |
PDHK3_TYR |
0.747 | 0.231 | 4 | 0.878 |
MST1 |
0.746 | -0.062 | 1 | 0.216 |
KHS2 |
0.746 | -0.008 | 1 | 0.228 |
MOK |
0.746 | -0.032 | 1 | 0.160 |
MEKK6 |
0.745 | -0.125 | 1 | 0.195 |
AKT3 |
0.745 | -0.011 | -3 | 0.602 |
HGK |
0.745 | -0.111 | 3 | 0.800 |
NEK4 |
0.745 | -0.160 | 1 | 0.172 |
KHS1 |
0.745 | -0.058 | 1 | 0.196 |
ROCK2 |
0.744 | -0.012 | -3 | 0.779 |
VRK1 |
0.744 | -0.101 | 2 | 0.846 |
PKN1 |
0.743 | -0.068 | -3 | 0.716 |
PDHK4_TYR |
0.743 | 0.183 | 2 | 0.891 |
IRAK1 |
0.743 | -0.203 | -1 | 0.772 |
PBK |
0.742 | -0.079 | 1 | 0.160 |
SLK |
0.742 | -0.076 | -2 | 0.698 |
STK33 |
0.742 | -0.099 | 2 | 0.619 |
CHK2 |
0.741 | -0.024 | -3 | 0.610 |
NEK1 |
0.741 | -0.145 | 1 | 0.171 |
BUB1 |
0.741 | -0.022 | -5 | 0.796 |
MRCKB |
0.741 | -0.033 | -3 | 0.722 |
CAMK1A |
0.741 | -0.029 | -3 | 0.622 |
LOK |
0.740 | -0.115 | -2 | 0.752 |
LRRK2 |
0.739 | -0.140 | 2 | 0.830 |
RIPK2 |
0.738 | -0.175 | 1 | 0.195 |
YSK1 |
0.738 | -0.115 | 2 | 0.779 |
MAP2K6_TYR |
0.737 | 0.170 | -1 | 0.882 |
MEK2 |
0.737 | -0.136 | 2 | 0.814 |
CK1A |
0.736 | 0.092 | -3 | 0.471 |
BMPR2_TYR |
0.736 | 0.188 | -1 | 0.856 |
OSR1 |
0.735 | -0.037 | 2 | 0.792 |
DMPK1 |
0.735 | -0.002 | -3 | 0.742 |
PDHK1_TYR |
0.734 | 0.118 | -1 | 0.887 |
BIKE |
0.734 | -0.057 | 1 | 0.168 |
MAP2K4_TYR |
0.733 | 0.050 | -1 | 0.880 |
SBK |
0.733 | -0.025 | -3 | 0.541 |
TXK |
0.732 | 0.265 | 1 | 0.397 |
TESK1_TYR |
0.732 | -0.016 | 3 | 0.855 |
HASPIN |
0.730 | -0.050 | -1 | 0.739 |
CRIK |
0.729 | -0.015 | -3 | 0.689 |
YANK3 |
0.729 | -0.027 | 2 | 0.419 |
ASK1 |
0.729 | -0.116 | 1 | 0.193 |
MAP2K7_TYR |
0.728 | -0.098 | 2 | 0.860 |
TTK |
0.728 | -0.058 | -2 | 0.831 |
ROCK1 |
0.728 | -0.038 | -3 | 0.740 |
PKG1 |
0.727 | -0.063 | -2 | 0.586 |
ALPHAK3 |
0.725 | -0.071 | -1 | 0.763 |
AAK1 |
0.725 | -0.040 | 1 | 0.130 |
PINK1_TYR |
0.724 | -0.109 | 1 | 0.227 |
PKMYT1_TYR |
0.723 | -0.101 | 3 | 0.816 |
NEK3 |
0.723 | -0.201 | 1 | 0.140 |
EPHB4 |
0.722 | 0.037 | -1 | 0.839 |
LIMK2_TYR |
0.721 | -0.099 | -3 | 0.901 |
EPHA6 |
0.721 | 0.018 | -1 | 0.838 |
SRMS |
0.720 | 0.119 | 1 | 0.323 |
STLK3 |
0.719 | -0.108 | 1 | 0.202 |
MYO3A |
0.719 | -0.114 | 1 | 0.182 |
MYO3B |
0.719 | -0.119 | 2 | 0.793 |
RET |
0.718 | -0.179 | 1 | 0.178 |
EPHA4 |
0.718 | 0.052 | 2 | 0.795 |
EPHB1 |
0.718 | 0.074 | 1 | 0.307 |
TAO1 |
0.717 | -0.144 | 1 | 0.162 |
INSRR |
0.717 | 0.037 | 3 | 0.691 |
YES1 |
0.716 | -0.019 | -1 | 0.844 |
ITK |
0.716 | 0.097 | -1 | 0.785 |
FGR |
0.715 | -0.011 | 1 | 0.263 |
FER |
0.713 | -0.005 | 1 | 0.281 |
EPHB2 |
0.713 | 0.038 | -1 | 0.814 |
TYRO3 |
0.713 | -0.086 | 3 | 0.733 |
DDR1 |
0.713 | -0.120 | 4 | 0.767 |
CSF1R |
0.712 | -0.123 | 3 | 0.725 |
LIMK1_TYR |
0.711 | -0.178 | 2 | 0.838 |
MST1R |
0.711 | -0.194 | 3 | 0.749 |
JAK3 |
0.711 | -0.125 | 1 | 0.196 |
NEK10_TYR |
0.711 | -0.149 | 1 | 0.136 |
EPHB3 |
0.711 | -0.008 | -1 | 0.819 |
ABL2 |
0.710 | -0.073 | -1 | 0.801 |
PTK2 |
0.710 | 0.186 | -1 | 0.756 |
MERTK |
0.710 | 0.042 | 3 | 0.724 |
TYK2 |
0.710 | -0.278 | 1 | 0.163 |
ROS1 |
0.709 | -0.136 | 3 | 0.702 |
BMX |
0.709 | 0.069 | -1 | 0.700 |
PTK2B |
0.709 | 0.158 | -1 | 0.765 |
FGFR2 |
0.709 | -0.119 | 3 | 0.755 |
JAK2 |
0.708 | -0.248 | 1 | 0.164 |
TNK2 |
0.707 | -0.098 | 3 | 0.702 |
EPHA7 |
0.707 | 0.024 | 2 | 0.788 |
KIT |
0.706 | -0.096 | 3 | 0.731 |
TEC |
0.706 | 0.037 | -1 | 0.730 |
SYK |
0.706 | 0.115 | -1 | 0.733 |
PDGFRB |
0.706 | -0.131 | 3 | 0.739 |
FYN |
0.706 | 0.021 | -1 | 0.769 |
AXL |
0.705 | -0.056 | 3 | 0.722 |
EGFR |
0.705 | -0.034 | 1 | 0.216 |
ABL1 |
0.704 | -0.100 | -1 | 0.793 |
FLT1 |
0.704 | -0.061 | -1 | 0.818 |
HCK |
0.704 | -0.093 | -1 | 0.801 |
NTRK1 |
0.703 | -0.042 | -1 | 0.821 |
CK1G3 |
0.703 | -0.010 | -3 | 0.420 |
EPHA5 |
0.703 | 0.028 | 2 | 0.787 |
EPHA3 |
0.702 | -0.015 | 2 | 0.767 |
BLK |
0.702 | -0.066 | -1 | 0.810 |
KDR |
0.702 | -0.129 | 3 | 0.695 |
MET |
0.702 | -0.068 | 3 | 0.724 |
FGFR1 |
0.701 | -0.174 | 3 | 0.715 |
LCK |
0.701 | -0.088 | -1 | 0.796 |
FGFR3 |
0.700 | -0.096 | 3 | 0.725 |
ERBB2 |
0.700 | -0.097 | 1 | 0.225 |
DDR2 |
0.699 | -0.060 | 3 | 0.684 |
TNK1 |
0.699 | -0.163 | 3 | 0.714 |
JAK1 |
0.698 | -0.173 | 1 | 0.161 |
FLT3 |
0.698 | -0.193 | 3 | 0.722 |
TEK |
0.698 | -0.142 | 3 | 0.671 |
NTRK3 |
0.698 | -0.038 | -1 | 0.765 |
WEE1_TYR |
0.698 | -0.079 | -1 | 0.745 |
YANK2 |
0.697 | -0.038 | 2 | 0.433 |
EPHA8 |
0.696 | -0.002 | -1 | 0.786 |
BTK |
0.696 | -0.113 | -1 | 0.755 |
INSR |
0.695 | -0.069 | 3 | 0.662 |
TNNI3K_TYR |
0.695 | -0.178 | 1 | 0.151 |
NTRK2 |
0.694 | -0.111 | 3 | 0.698 |
FLT4 |
0.694 | -0.140 | 3 | 0.701 |
ERBB4 |
0.694 | 0.007 | 1 | 0.278 |
SRC |
0.693 | -0.032 | -1 | 0.777 |
LTK |
0.693 | -0.119 | 3 | 0.685 |
ALK |
0.693 | -0.101 | 3 | 0.654 |
PDGFRA |
0.693 | -0.232 | 3 | 0.732 |
EPHA2 |
0.693 | 0.024 | -1 | 0.750 |
FRK |
0.692 | -0.101 | -1 | 0.812 |
EPHA1 |
0.691 | -0.111 | 3 | 0.692 |
MATK |
0.691 | -0.063 | -1 | 0.737 |
FGFR4 |
0.691 | -0.081 | -1 | 0.760 |
PTK6 |
0.690 | -0.164 | -1 | 0.716 |
CSK |
0.688 | -0.087 | 2 | 0.791 |
LYN |
0.687 | -0.105 | 3 | 0.650 |
IGF1R |
0.685 | -0.027 | 3 | 0.607 |
CK1G2 |
0.684 | -0.001 | -3 | 0.511 |
MUSK |
0.680 | -0.121 | 1 | 0.197 |
ZAP70 |
0.679 | -0.016 | -1 | 0.661 |
FES |
0.677 | 0.052 | -1 | 0.678 |