Motif 43 (n=97)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AVK6 | E2F8 | S351 | ochoa | Transcription factor E2F8 (E2F-8) | Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}. |
| A1YPR0 | ZBTB7C | S215 | ochoa | Zinc finger and BTB domain-containing protein 7C (Affected by papillomavirus DNA integration in ME180 cells protein 1) (APM-1) (Zinc finger and BTB domain-containing protein 36) (Zinc finger protein 857C) | May be a tumor suppressor gene. {ECO:0000269|PubMed:9427755}. |
| O00746 | NME4 | S153 | ochoa | Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as a mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:17028143, PubMed:18635542, PubMed:23150663). {ECO:0000269|PubMed:10799505, ECO:0000269|PubMed:17028143, ECO:0000269|PubMed:18635542, ECO:0000269|PubMed:23150663, ECO:0000305, ECO:0000305|PubMed:24970086}. |
| O15213 | WDR46 | S41 | ochoa | WD repeat-containing protein 46 (WD repeat-containing protein BING4) | Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}. |
| O43524 | FOXO3 | S43 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O43896 | KIF1C | S990 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O75152 | ZC3H11A | T502 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O95696 | BRD1 | S25 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95696 | BRD1 | S814 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| P10070 | GLI2 | S839 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P14618 | PKM | S287 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P18206 | VCL | S290 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P29375 | KDM5A | S1438 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P29692 | EEF1D | S37 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P29692 | EEF1D | S70 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P30305 | CDC25B | S249 | ochoa|psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P33176 | KIF5B | S933 | ochoa | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P37275 | ZEB1 | S319 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P38936 | CDKN1A | S130 | ochoa|psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P40189 | IL6ST | S825 | ochoa | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) | Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:19915009, PubMed:2261637, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}. |
| P46934 | NEDD4 | S737 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P49137 | MAPKAPK2 | S272 | psp | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}. |
| P53990 | IST1 | S307 | ochoa | IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) | ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| P55196 | AFDN | S1779 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56182 | RRP1 | S383 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
| P57059 | SIK1 | S634 | ochoa | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| P85037 | FOXK1 | S420 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P98175 | RBM10 | S73 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q01167 | FOXK2 | S373 | ochoa|psp | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02156 | PRKCE | S388 | ochoa | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q08499 | PDE4D | S171 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q09666 | AHNAK | S337 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13572 | ITPK1 | S358 | ochoa | Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159) | Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 (PubMed:11042108, PubMed:8662638). Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 (PubMed:11042108). This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:11042108, PubMed:8662638). Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4 (PubMed:11909533, PubMed:17616525). May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium (PubMed:11909533). Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11042108, ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525, ECO:0000269|PubMed:8662638}. |
| Q13671 | RIN1 | S42 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14004 | CDK13 | S1153 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q15036 | SNX17 | S333 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q16644 | MAPKAPK3 | S251 | psp | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:15563468, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20599781, ECO:0000269|PubMed:8626550, ECO:0000269|PubMed:8774846}. |
| Q2LD37 | BLTP1 | S3653 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q32MQ0 | ZNF750 | S136 | ochoa | Zinc finger protein 750 | Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. {ECO:0000269|PubMed:22364861}. |
| Q3B820 | FAM161A | S462 | ochoa | Protein FAM161A | Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}. |
| Q3T8J9 | GON4L | S1902 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q4FZB7 | KMT5B | S532 | ochoa | Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}. |
| Q53ET0 | CRTC2 | S624 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5FBB7 | SGO1 | S468 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5FWE3 | PRRT3 | S841 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5T7B8 | KIF24 | S646 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5T7B8 | KIF24 | S1275 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5TH69 | ARFGEF3 | S295 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VST9 | OBSCN | S7450 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VYV7 | SLX4IP | S280 | ochoa | Protein SLX4IP (SLX4-interacting protein) | None |
| Q63HR2 | TNS2 | S941 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q68DQ2 | CRYBG3 | S2104 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6BDS2 | BLTP3A | S928 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6NUJ5 | PWWP2B | S191 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6PIY7 | TENT2 | S69 | ochoa | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
| Q6ZUM4 | ARHGAP27 | S466 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q7Z434 | MAVS | S462 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q86U90 | YRDC | S60 | ochoa | Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP) | Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459). Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464). Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464). May regulate the activity of some transporters (By similarity). {ECO:0000250|UniProtKB:Q3U5F4, ECO:0000269|PubMed:29760464, ECO:0000269|PubMed:31481669, ECO:0000269|PubMed:34545459}. |
| Q86US8 | SMG6 | S484 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q8IU81 | IRF2BP1 | S125 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8N163 | CCAR2 | S23 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N3F8 | MICALL1 | S578 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8NB15 | ZNF511 | S214 | ochoa | Zinc finger protein 511 | May be involved in transcriptional regulation. {ECO:0000305}. |
| Q8NC44 | RETREG2 | S316 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8NFF5 | FLAD1 | S103 | ochoa | FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] | Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:27259049}. |
| Q8NFU3 | TSTD1 | S94 | ochoa | Thiosulfate:glutathione sulfurtransferase (TST) (EC 2.8.1.3) | Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). GSS(-) spontaneously reacts with glutathione to form glutathione disulfide (Probable). {ECO:0000269|PubMed:24981631, ECO:0000305}. |
| Q8TF44 | C2CD4C | S273 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WWQ0 | PHIP | S683 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q92783 | STAM | S156 | ochoa | Signal transducing adapter molecule 1 (STAM-1) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}. |
| Q96HA9 | PEX11G | S164 | ochoa | Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (Protein PEX11 homolog gamma) (PEX11-gamma) | Promotes membrane protrusion and elongation on the peroxisomal surface. {ECO:0000269|PubMed:20826455}. |
| Q96PY6 | NEK1 | S881 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96RY7 | IFT140 | S360 | ochoa | Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) | Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:20889716, PubMed:22503633). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22503633). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). {ECO:0000250|UniProtKB:E9PY46, ECO:0000269|PubMed:20889716, ECO:0000269|PubMed:22503633, ECO:0000269|PubMed:28724397}. |
| Q96TA1 | NIBAN2 | S646 | ochoa|psp | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99698 | LYST | S1516 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BX67 | JAM3 | S281 | ochoa|psp | Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). {ECO:0000250|UniProtKB:A3KPA0, ECO:0000250|UniProtKB:Q9D8B7, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11823489, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:23255084, ECO:0000269|PubMed:24357068, ECO:0000305|PubMed:28196865}.; FUNCTION: [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. {ECO:0000269|PubMed:20592283}. |
| Q9BYX4 | IFIH1 | S490 | ochoa | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:28594402, PubMed:32169843, PubMed:33727702). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. {ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19656871, ECO:0000269|PubMed:21217758, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:22160685, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:28606988, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:33514628, ECO:0000269|PubMed:33727702}. |
| Q9C0C2 | TNKS1BP1 | S504 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H1I8 | ASCC2 | S713 | ochoa | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q9H3Q1 | CDC42EP4 | S322 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4G0 | EPB41L1 | S544 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9HAH7 | FBRS | S281 | ochoa | Probable fibrosin-1 | None |
| Q9HAW4 | CLSPN | S846 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HB19 | PLEKHA2 | S194 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9NP31 | SH2D2A | S43 | ochoa | SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Q9NQU5 | PAK6 | S207 | ochoa | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NRL2 | BAZ1A | S270 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NVE7 | PANK4 | S393 | ochoa | 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) | Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}. |
| Q9P0K8 | FOXJ2 | S170 | ochoa | Forkhead box protein J2 (Fork head homologous X) | [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}. |
| Q9UBS8 | RNF14 | S162 | ochoa | E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (PubMed:36638793, PubMed:37651229). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (PubMed:37951215, PubMed:37951216). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326). {ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:23449499, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q9UER7 | DAXX | S424 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UHF7 | TRPS1 | S810 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UMN6 | KMT2B | S1039 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9Y2H0 | DLGAP4 | S775 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2K7 | KDM2A | S558 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y2R2 | PTPN22 | S692 | ochoa | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}. |
| Q9Y230 | RUVBL2 | S43 | Sugiyama | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| Q8WWI1 | LMO7 | S1410 | Sugiyama | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.000011 | 4.942 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.000011 | 4.942 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.000013 | 4.877 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.000042 | 4.372 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.000042 | 4.372 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.000100 | 3.998 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.000246 | 3.609 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.000840 | 3.076 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.001266 | 2.897 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.001479 | 2.830 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.001537 | 2.813 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.001537 | 2.813 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.001202 | 2.920 |
| R-HSA-5688426 | Deubiquitination | 0.003228 | 2.491 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.003716 | 2.430 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.004409 | 2.356 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.013815 | 1.860 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.013815 | 1.860 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.013815 | 1.860 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.013815 | 1.860 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.013815 | 1.860 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.007540 | 2.123 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.015467 | 1.811 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.009612 | 2.017 |
| R-HSA-983189 | Kinesins | 0.012195 | 1.914 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.007587 | 2.120 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.007587 | 2.120 |
| R-HSA-171007 | p38MAPK events | 0.007940 | 2.100 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.013676 | 1.864 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.009612 | 2.017 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.008914 | 2.050 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.007940 | 2.100 |
| R-HSA-4839726 | Chromatin organization | 0.011579 | 1.936 |
| R-HSA-167044 | Signalling to RAS | 0.014407 | 1.841 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.011427 | 1.942 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.013380 | 1.874 |
| R-HSA-449147 | Signaling by Interleukins | 0.005492 | 2.260 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.015467 | 1.811 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.005965 | 2.224 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.017514 | 1.757 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.017684 | 1.752 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.018840 | 1.725 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.018840 | 1.725 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.018840 | 1.725 |
| R-HSA-3214842 | HDMs demethylate histones | 0.020027 | 1.698 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.018840 | 1.725 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.019954 | 1.700 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.020536 | 1.687 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.021244 | 1.673 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.022492 | 1.648 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.027774 | 1.556 |
| R-HSA-182971 | EGFR downregulation | 0.027774 | 1.556 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.025076 | 1.601 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.027774 | 1.556 |
| R-HSA-418990 | Adherens junctions interactions | 0.025822 | 1.588 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.029165 | 1.535 |
| R-HSA-70268 | Pyruvate metabolism | 0.029875 | 1.525 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.030584 | 1.515 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.040880 | 1.388 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.043548 | 1.361 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.044510 | 1.352 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.038071 | 1.419 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.042900 | 1.368 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.034999 | 1.456 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.044510 | 1.352 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.045343 | 1.343 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.039188 | 1.407 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.040100 | 1.397 |
| R-HSA-421270 | Cell-cell junction organization | 0.041431 | 1.383 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.038071 | 1.419 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.036523 | 1.437 |
| R-HSA-187687 | Signalling to ERKs | 0.034999 | 1.456 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.045667 | 1.340 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.045667 | 1.340 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.047112 | 1.327 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 0.073678 | 1.133 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.111572 | 0.952 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.166090 | 0.780 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.213614 | 0.670 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.213614 | 0.670 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.147928 | 0.830 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.054135 | 1.267 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.158766 | 0.799 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.166090 | 0.780 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.092821 | 1.032 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.111572 | 0.952 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.111572 | 0.952 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.227126 | 0.644 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.107416 | 0.969 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.057116 | 1.243 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.105365 | 0.977 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.159824 | 0.796 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.073678 | 1.133 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.086484 | 1.063 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.159716 | 0.797 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.105365 | 0.977 |
| R-HSA-73942 | DNA Damage Reversal | 0.123858 | 0.907 |
| R-HSA-5617833 | Cilium Assembly | 0.178721 | 0.748 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.080103 | 1.096 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.199716 | 0.700 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.085912 | 1.066 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.221720 | 0.654 |
| R-HSA-72312 | rRNA processing | 0.099695 | 1.001 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.065954 | 1.181 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.094320 | 1.025 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.111572 | 0.952 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.205274 | 0.688 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.185891 | 0.731 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.047530 | 1.323 |
| R-HSA-199920 | CREB phosphorylation | 0.060695 | 1.217 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.067209 | 1.173 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.080103 | 1.096 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.086484 | 1.063 |
| R-HSA-428540 | Activation of RAC1 | 0.099114 | 1.004 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.123858 | 0.907 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.188484 | 0.725 |
| R-HSA-429947 | Deadenylation of mRNA | 0.188484 | 0.725 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.087998 | 1.056 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.227126 | 0.644 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.105365 | 0.977 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.081786 | 1.087 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.212527 | 0.673 |
| R-HSA-196843 | Vitamin B2 (riboflavin) metabolism | 0.117736 | 0.929 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.205274 | 0.688 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.146705 | 0.834 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.054856 | 1.261 |
| R-HSA-5689603 | UCH proteinases | 0.116383 | 0.934 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.137203 | 0.863 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.123858 | 0.907 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.141973 | 0.848 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.141973 | 0.848 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.177096 | 0.752 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.182810 | 0.738 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.221720 | 0.654 |
| R-HSA-157579 | Telomere Maintenance | 0.173472 | 0.761 |
| R-HSA-8953854 | Metabolism of RNA | 0.075185 | 1.124 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.086484 | 1.063 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.177096 | 0.752 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.190894 | 0.719 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.182810 | 0.738 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.065954 | 1.181 |
| R-HSA-2559583 | Cellular Senescence | 0.050834 | 1.294 |
| R-HSA-3214847 | HATs acetylate histones | 0.178423 | 0.749 |
| R-HSA-450294 | MAP kinase activation | 0.083841 | 1.077 |
| R-HSA-177929 | Signaling by EGFR | 0.073731 | 1.132 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.218700 | 0.660 |
| R-HSA-448424 | Interleukin-17 signaling | 0.103006 | 0.987 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.061671 | 1.210 |
| R-HSA-1640170 | Cell Cycle | 0.068176 | 1.166 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.105365 | 0.977 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.135976 | 0.867 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.084931 | 1.071 |
| R-HSA-9833110 | RSV-host interactions | 0.193403 | 0.714 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.071053 | 1.148 |
| R-HSA-194138 | Signaling by VEGF | 0.074729 | 1.127 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.063797 | 1.195 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.210794 | 0.676 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.185891 | 0.731 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.234017 | 0.631 |
| R-HSA-446728 | Cell junction organization | 0.057703 | 1.239 |
| R-HSA-1181150 | Signaling by NODAL | 0.159716 | 0.797 |
| R-HSA-180024 | DARPP-32 events | 0.216276 | 0.665 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.198433 | 0.702 |
| R-HSA-1500931 | Cell-Cell communication | 0.086016 | 1.065 |
| R-HSA-69275 | G2/M Transition | 0.171871 | 0.765 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.175286 | 0.756 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.150175 | 0.823 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.232495 | 0.634 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.170789 | 0.768 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.177096 | 0.752 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.051320 | 1.290 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.190894 | 0.719 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.203479 | 0.691 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.216276 | 0.665 |
| R-HSA-264876 | Insulin processing | 0.205274 | 0.688 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.175945 | 0.755 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.175945 | 0.755 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.175945 | 0.755 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.199716 | 0.700 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.206007 | 0.686 |
| R-HSA-168256 | Immune System | 0.068584 | 1.164 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.208539 | 0.681 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.236577 | 0.626 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.208539 | 0.681 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.236577 | 0.626 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.195916 | 0.708 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.216155 | 0.665 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.223796 | 0.650 |
| R-HSA-109582 | Hemostasis | 0.198264 | 0.703 |
| R-HSA-70171 | Glycolysis | 0.180907 | 0.743 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.196164 | 0.707 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.066285 | 1.179 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.153536 | 0.814 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.232495 | 0.634 |
| R-HSA-70326 | Glucose metabolism | 0.231459 | 0.636 |
| R-HSA-6806834 | Signaling by MET | 0.125534 | 0.901 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.237828 | 0.624 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.237828 | 0.624 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.237828 | 0.624 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.237828 | 0.624 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.237828 | 0.624 |
| R-HSA-3371556 | Cellular response to heat stress | 0.241702 | 0.617 |
| R-HSA-73886 | Chromosome Maintenance | 0.241702 | 0.617 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.243123 | 0.614 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.243123 | 0.614 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.243123 | 0.614 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.244266 | 0.612 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.244266 | 0.612 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.245040 | 0.611 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.246832 | 0.608 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.253606 | 0.596 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.258793 | 0.587 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.258793 | 0.587 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.262242 | 0.581 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.263944 | 0.578 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.274140 | 0.562 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.274140 | 0.562 |
| R-HSA-9909396 | Circadian clock | 0.275093 | 0.561 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.279186 | 0.554 |
| R-HSA-9607240 | FLT3 Signaling | 0.284196 | 0.546 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.284196 | 0.546 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.289173 | 0.539 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.289173 | 0.539 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.289173 | 0.539 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.289173 | 0.539 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.290501 | 0.537 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.292743 | 0.534 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.293066 | 0.533 |
| R-HSA-212436 | Generic Transcription Pathway | 0.298644 | 0.525 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.299022 | 0.524 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.303897 | 0.517 |
| R-HSA-69236 | G1 Phase | 0.303897 | 0.517 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.303897 | 0.517 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.303897 | 0.517 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.304288 | 0.517 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.305872 | 0.514 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.308428 | 0.511 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.308737 | 0.510 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.308737 | 0.510 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.309714 | 0.509 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.313544 | 0.504 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.313544 | 0.504 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.313544 | 0.504 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.313544 | 0.504 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.313544 | 0.504 |
| R-HSA-75153 | Apoptotic execution phase | 0.313544 | 0.504 |
| R-HSA-69242 | S Phase | 0.321183 | 0.493 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.321183 | 0.493 |
| R-HSA-166520 | Signaling by NTRKs | 0.321183 | 0.493 |
| R-HSA-199991 | Membrane Trafficking | 0.322095 | 0.492 |
| R-HSA-5620924 | Intraflagellar transport | 0.323059 | 0.491 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.336414 | 0.473 |
| R-HSA-73887 | Death Receptor Signaling | 0.336414 | 0.473 |
| R-HSA-72187 | mRNA 3'-end processing | 0.341699 | 0.466 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.346279 | 0.461 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.346279 | 0.461 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.351545 | 0.454 |
| R-HSA-418597 | G alpha (z) signalling events | 0.355344 | 0.449 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.359830 | 0.444 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.359830 | 0.444 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.359830 | 0.444 |
| R-HSA-75893 | TNF signaling | 0.359830 | 0.444 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.364285 | 0.439 |
| R-HSA-162582 | Signal Transduction | 0.369069 | 0.433 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.373103 | 0.428 |
| R-HSA-180786 | Extension of Telomeres | 0.373103 | 0.428 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.375345 | 0.426 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.377466 | 0.423 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.381799 | 0.418 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.386102 | 0.413 |
| R-HSA-9707616 | Heme signaling | 0.386102 | 0.413 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.386102 | 0.413 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.386102 | 0.413 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.391285 | 0.408 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.398835 | 0.399 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.411306 | 0.386 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.411306 | 0.386 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.419477 | 0.377 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.423520 | 0.373 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.423520 | 0.373 |
| R-HSA-6798695 | Neutrophil degranulation | 0.426160 | 0.370 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.427536 | 0.369 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.427536 | 0.369 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.427536 | 0.369 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.429925 | 0.367 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.431523 | 0.365 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.431523 | 0.365 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.435483 | 0.361 |
| R-HSA-2262752 | Cellular responses to stress | 0.436078 | 0.360 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.439416 | 0.357 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.451052 | 0.346 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.451052 | 0.346 |
| R-HSA-216083 | Integrin cell surface interactions | 0.451052 | 0.346 |
| R-HSA-9659379 | Sensory processing of sound | 0.454878 | 0.342 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.458056 | 0.339 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.458677 | 0.338 |
| R-HSA-9833482 | PKR-mediated signaling | 0.458677 | 0.338 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.458677 | 0.338 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.460444 | 0.337 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.462449 | 0.335 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.462449 | 0.335 |
| R-HSA-1280218 | Adaptive Immune System | 0.465900 | 0.332 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.466196 | 0.331 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.466196 | 0.331 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.471214 | 0.327 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.477281 | 0.321 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.477281 | 0.321 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.480925 | 0.318 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.480925 | 0.318 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.480925 | 0.318 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.484544 | 0.315 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.488138 | 0.311 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.488138 | 0.311 |
| R-HSA-68882 | Mitotic Anaphase | 0.489854 | 0.310 |
| R-HSA-156902 | Peptide chain elongation | 0.491707 | 0.308 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.492081 | 0.308 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.498771 | 0.302 |
| R-HSA-8951664 | Neddylation | 0.500929 | 0.300 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.502267 | 0.299 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.505738 | 0.296 |
| R-HSA-391251 | Protein folding | 0.509186 | 0.293 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.516176 | 0.287 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.519394 | 0.285 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.520476 | 0.284 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.522739 | 0.282 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.522739 | 0.282 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.522739 | 0.282 |
| R-HSA-74160 | Gene expression (Transcription) | 0.524579 | 0.280 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.529375 | 0.276 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.535327 | 0.271 |
| R-HSA-913531 | Interferon Signaling | 0.535353 | 0.271 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.535921 | 0.271 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.539159 | 0.268 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.542376 | 0.266 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.542376 | 0.266 |
| R-HSA-1483255 | PI Metabolism | 0.545570 | 0.263 |
| R-HSA-192823 | Viral mRNA Translation | 0.548742 | 0.261 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.551892 | 0.258 |
| R-HSA-111885 | Opioid Signalling | 0.551892 | 0.258 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.564276 | 0.249 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.567318 | 0.246 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.567318 | 0.246 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.567318 | 0.246 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.570340 | 0.244 |
| R-HSA-202403 | TCR signaling | 0.573340 | 0.242 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.579279 | 0.237 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.585136 | 0.233 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.586372 | 0.232 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.593771 | 0.226 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.596609 | 0.224 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.596609 | 0.224 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.599428 | 0.222 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.599428 | 0.222 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.599428 | 0.222 |
| R-HSA-168249 | Innate Immune System | 0.602134 | 0.220 |
| R-HSA-5693538 | Homology Directed Repair | 0.602227 | 0.220 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.608541 | 0.216 |
| R-HSA-72766 | Translation | 0.608696 | 0.216 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.610509 | 0.214 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.617743 | 0.209 |
| R-HSA-69206 | G1/S Transition | 0.623933 | 0.205 |
| R-HSA-114608 | Platelet degranulation | 0.629174 | 0.201 |
| R-HSA-69481 | G2/M Checkpoints | 0.629174 | 0.201 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.646953 | 0.189 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.647801 | 0.189 |
| R-HSA-6807070 | PTEN Regulation | 0.663886 | 0.178 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.673198 | 0.172 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.682255 | 0.166 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.693226 | 0.159 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.695375 | 0.158 |
| R-HSA-2142753 | Arachidonate metabolism | 0.695375 | 0.158 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.697509 | 0.156 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.699628 | 0.155 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.701732 | 0.154 |
| R-HSA-162587 | HIV Life Cycle | 0.705897 | 0.151 |
| R-HSA-9711097 | Cellular response to starvation | 0.707958 | 0.150 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.712037 | 0.147 |
| R-HSA-109581 | Apoptosis | 0.716059 | 0.145 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.720026 | 0.143 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.720026 | 0.143 |
| R-HSA-1266738 | Developmental Biology | 0.728612 | 0.138 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.729647 | 0.137 |
| R-HSA-392499 | Metabolism of proteins | 0.730690 | 0.136 |
| R-HSA-72306 | tRNA processing | 0.733482 | 0.135 |
| R-HSA-418555 | G alpha (s) signalling events | 0.735351 | 0.134 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.740881 | 0.130 |
| R-HSA-597592 | Post-translational protein modification | 0.742961 | 0.129 |
| R-HSA-73894 | DNA Repair | 0.744488 | 0.128 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.749711 | 0.125 |
| R-HSA-168255 | Influenza Infection | 0.749844 | 0.125 |
| R-HSA-983712 | Ion channel transport | 0.766859 | 0.115 |
| R-HSA-68886 | M Phase | 0.773295 | 0.112 |
| R-HSA-68877 | Mitotic Prometaphase | 0.773339 | 0.112 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.774931 | 0.111 |
| R-HSA-9609690 | HCMV Early Events | 0.778082 | 0.109 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.782638 | 0.106 |
| R-HSA-72172 | mRNA Splicing | 0.791728 | 0.101 |
| R-HSA-5357801 | Programmed Cell Death | 0.793191 | 0.101 |
| R-HSA-397014 | Muscle contraction | 0.803157 | 0.095 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.803157 | 0.095 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.821682 | 0.085 |
| R-HSA-162906 | HIV Infection | 0.822938 | 0.085 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.825421 | 0.083 |
| R-HSA-15869 | Metabolism of nucleotides | 0.833846 | 0.079 |
| R-HSA-8939211 | ESR-mediated signaling | 0.835017 | 0.078 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.846857 | 0.072 |
| R-HSA-9609646 | HCMV Infection | 0.849506 | 0.071 |
| R-HSA-112316 | Neuronal System | 0.857448 | 0.067 |
| R-HSA-416476 | G alpha (q) signalling events | 0.863702 | 0.064 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.867508 | 0.062 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.885828 | 0.053 |
| R-HSA-1483257 | Phospholipid metabolism | 0.890585 | 0.050 |
| R-HSA-422475 | Axon guidance | 0.907651 | 0.042 |
| R-HSA-9824446 | Viral Infection Pathways | 0.907787 | 0.042 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.910312 | 0.041 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.910312 | 0.041 |
| R-HSA-9679506 | SARS-CoV Infections | 0.912811 | 0.040 |
| R-HSA-1474244 | Extracellular matrix organization | 0.915270 | 0.038 |
| R-HSA-388396 | GPCR downstream signalling | 0.918739 | 0.037 |
| R-HSA-9675108 | Nervous system development | 0.925437 | 0.034 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.932528 | 0.030 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.939627 | 0.027 |
| R-HSA-372790 | Signaling by GPCR | 0.947272 | 0.024 |
| R-HSA-1643685 | Disease | 0.947321 | 0.024 |
| R-HSA-418594 | G alpha (i) signalling events | 0.951058 | 0.022 |
| R-HSA-8978868 | Fatty acid metabolism | 0.951058 | 0.022 |
| R-HSA-5663205 | Infectious disease | 0.960088 | 0.018 |
| R-HSA-382551 | Transport of small molecules | 0.999250 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999794 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999889 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999936 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.819 | 0.583 | 1 | 0.907 |
CDK18 |
0.809 | 0.611 | 1 | 0.928 |
CDK19 |
0.806 | 0.600 | 1 | 0.919 |
P38G |
0.802 | 0.631 | 1 | 0.936 |
CDK17 |
0.802 | 0.610 | 1 | 0.933 |
CDK8 |
0.802 | 0.595 | 1 | 0.907 |
HIPK2 |
0.800 | 0.568 | 1 | 0.912 |
JNK2 |
0.797 | 0.631 | 1 | 0.939 |
ERK1 |
0.797 | 0.602 | 1 | 0.913 |
CDK1 |
0.797 | 0.582 | 1 | 0.928 |
P38D |
0.797 | 0.620 | 1 | 0.941 |
CDK16 |
0.796 | 0.585 | 1 | 0.931 |
CDK5 |
0.795 | 0.578 | 1 | 0.903 |
CDK3 |
0.795 | 0.538 | 1 | 0.935 |
P38B |
0.795 | 0.608 | 1 | 0.904 |
CDK7 |
0.794 | 0.567 | 1 | 0.923 |
CDK13 |
0.792 | 0.583 | 1 | 0.931 |
JNK3 |
0.791 | 0.616 | 1 | 0.929 |
CLK3 |
0.790 | 0.369 | 1 | 0.741 |
DYRK2 |
0.789 | 0.532 | 1 | 0.876 |
CDK12 |
0.788 | 0.580 | 1 | 0.936 |
HIPK4 |
0.785 | 0.381 | 1 | 0.738 |
P38A |
0.785 | 0.580 | 1 | 0.873 |
DYRK4 |
0.782 | 0.535 | 1 | 0.929 |
CDK9 |
0.782 | 0.572 | 1 | 0.928 |
CDK14 |
0.781 | 0.555 | 1 | 0.914 |
HIPK1 |
0.781 | 0.501 | 1 | 0.868 |
NLK |
0.780 | 0.491 | 1 | 0.767 |
ERK2 |
0.778 | 0.563 | 1 | 0.901 |
JNK1 |
0.774 | 0.548 | 1 | 0.936 |
CDK10 |
0.773 | 0.511 | 1 | 0.921 |
HIPK3 |
0.773 | 0.490 | 1 | 0.843 |
DYRK1B |
0.772 | 0.502 | 1 | 0.901 |
ERK5 |
0.771 | 0.287 | 1 | 0.666 |
DYRK1A |
0.770 | 0.427 | 1 | 0.871 |
MTOR |
0.770 | 0.156 | 1 | 0.590 |
SRPK1 |
0.766 | 0.213 | -3 | 0.647 |
COT |
0.765 | -0.035 | 2 | 0.700 |
CDC7 |
0.765 | 0.021 | 1 | 0.492 |
CDK2 |
0.765 | 0.419 | 1 | 0.858 |
CDK6 |
0.765 | 0.523 | 1 | 0.918 |
CLK2 |
0.765 | 0.288 | -3 | 0.620 |
CLK1 |
0.761 | 0.279 | -3 | 0.605 |
CDK4 |
0.760 | 0.537 | 1 | 0.936 |
NEK6 |
0.760 | 0.053 | -2 | 0.797 |
MOS |
0.760 | 0.036 | 1 | 0.527 |
CLK4 |
0.760 | 0.258 | -3 | 0.629 |
MAK |
0.760 | 0.375 | -2 | 0.688 |
ICK |
0.759 | 0.240 | -3 | 0.748 |
BMPR1B |
0.759 | 0.132 | 1 | 0.441 |
PRP4 |
0.759 | 0.348 | -3 | 0.753 |
DYRK3 |
0.758 | 0.370 | 1 | 0.836 |
PRPK |
0.756 | -0.031 | -1 | 0.602 |
CDKL5 |
0.755 | 0.101 | -3 | 0.696 |
ATR |
0.754 | 0.017 | 1 | 0.492 |
TGFBR2 |
0.754 | 0.060 | -2 | 0.821 |
DSTYK |
0.753 | -0.053 | 2 | 0.712 |
GCN2 |
0.753 | -0.106 | 2 | 0.633 |
TBK1 |
0.752 | -0.084 | 1 | 0.390 |
SRPK2 |
0.752 | 0.155 | -3 | 0.560 |
BMPR2 |
0.751 | -0.027 | -2 | 0.816 |
CDKL1 |
0.751 | 0.057 | -3 | 0.706 |
PDHK4 |
0.750 | -0.102 | 1 | 0.515 |
NEK7 |
0.750 | -0.044 | -3 | 0.818 |
NDR2 |
0.749 | -0.005 | -3 | 0.755 |
IKKB |
0.748 | -0.112 | -2 | 0.659 |
TGFBR1 |
0.748 | 0.121 | -2 | 0.864 |
IKKE |
0.748 | -0.116 | 1 | 0.383 |
SRPK3 |
0.747 | 0.138 | -3 | 0.619 |
RAF1 |
0.747 | -0.143 | 1 | 0.456 |
ALK4 |
0.746 | 0.115 | -2 | 0.869 |
PDHK1 |
0.746 | -0.058 | 1 | 0.485 |
PRKD1 |
0.745 | 0.016 | -3 | 0.740 |
CHAK2 |
0.744 | -0.051 | -1 | 0.548 |
MLK1 |
0.744 | -0.108 | 2 | 0.653 |
PIM3 |
0.744 | -0.056 | -3 | 0.742 |
ERK7 |
0.743 | 0.174 | 2 | 0.434 |
ULK2 |
0.743 | -0.143 | 2 | 0.604 |
MST4 |
0.742 | -0.028 | 2 | 0.772 |
IKKA |
0.742 | -0.041 | -2 | 0.660 |
MOK |
0.741 | 0.322 | 1 | 0.769 |
BMPR1A |
0.741 | 0.110 | 1 | 0.430 |
AURC |
0.740 | 0.027 | -2 | 0.617 |
ACVR2A |
0.740 | 0.058 | -2 | 0.800 |
GRK1 |
0.740 | -0.032 | -2 | 0.704 |
ACVR2B |
0.740 | 0.054 | -2 | 0.807 |
CAMK1B |
0.740 | -0.079 | -3 | 0.745 |
MLK3 |
0.740 | -0.042 | 2 | 0.589 |
SKMLCK |
0.740 | -0.043 | -2 | 0.794 |
GRK7 |
0.738 | 0.025 | 1 | 0.462 |
ALK2 |
0.738 | 0.089 | -2 | 0.853 |
MLK2 |
0.738 | -0.072 | 2 | 0.664 |
NIK |
0.738 | -0.092 | -3 | 0.777 |
CAMLCK |
0.738 | -0.037 | -2 | 0.778 |
RIPK3 |
0.738 | -0.141 | 3 | 0.785 |
CAMK2G |
0.737 | -0.126 | 2 | 0.622 |
GRK5 |
0.737 | -0.125 | -3 | 0.787 |
NEK9 |
0.737 | -0.098 | 2 | 0.684 |
TLK2 |
0.737 | 0.059 | 1 | 0.408 |
WNK1 |
0.737 | -0.087 | -2 | 0.784 |
RSK2 |
0.736 | -0.029 | -3 | 0.658 |
PRKD2 |
0.736 | -0.015 | -3 | 0.654 |
NDR1 |
0.736 | -0.075 | -3 | 0.731 |
ULK1 |
0.735 | -0.133 | -3 | 0.775 |
NUAK2 |
0.734 | -0.037 | -3 | 0.718 |
LATS2 |
0.734 | -0.042 | -5 | 0.716 |
PKN3 |
0.734 | -0.091 | -3 | 0.724 |
RSK3 |
0.734 | -0.038 | -3 | 0.656 |
DAPK2 |
0.734 | -0.070 | -3 | 0.763 |
IRE1 |
0.733 | -0.073 | 1 | 0.418 |
PINK1 |
0.733 | 0.113 | 1 | 0.600 |
BCKDK |
0.733 | -0.143 | -1 | 0.522 |
PKCD |
0.732 | -0.061 | 2 | 0.612 |
GSK3A |
0.732 | 0.141 | 4 | 0.364 |
P90RSK |
0.732 | -0.044 | -3 | 0.666 |
PKN2 |
0.731 | -0.105 | -3 | 0.720 |
ATM |
0.731 | -0.071 | 1 | 0.447 |
MLK4 |
0.731 | -0.074 | 2 | 0.562 |
ANKRD3 |
0.731 | -0.145 | 1 | 0.459 |
PIM1 |
0.730 | -0.036 | -3 | 0.662 |
FAM20C |
0.730 | -0.028 | 2 | 0.468 |
P70S6KB |
0.730 | -0.046 | -3 | 0.667 |
PHKG1 |
0.730 | -0.060 | -3 | 0.706 |
PKR |
0.730 | -0.045 | 1 | 0.459 |
SMG1 |
0.730 | -0.057 | 1 | 0.459 |
GRK4 |
0.730 | -0.127 | -2 | 0.743 |
CAMK2D |
0.729 | -0.090 | -3 | 0.735 |
MPSK1 |
0.729 | 0.064 | 1 | 0.458 |
TTBK2 |
0.729 | -0.151 | 2 | 0.550 |
VRK2 |
0.729 | 0.028 | 1 | 0.543 |
MAPKAPK3 |
0.729 | -0.077 | -3 | 0.664 |
DNAPK |
0.729 | -0.029 | 1 | 0.429 |
PKCA |
0.729 | -0.042 | 2 | 0.573 |
HUNK |
0.728 | -0.133 | 2 | 0.623 |
MAPKAPK2 |
0.728 | -0.037 | -3 | 0.622 |
LATS1 |
0.728 | -0.027 | -3 | 0.787 |
PKCB |
0.728 | -0.051 | 2 | 0.584 |
MNK2 |
0.728 | -0.038 | -2 | 0.724 |
MASTL |
0.728 | -0.195 | -2 | 0.728 |
DLK |
0.727 | -0.201 | 1 | 0.461 |
GRK6 |
0.727 | -0.139 | 1 | 0.461 |
PKACG |
0.727 | -0.062 | -2 | 0.679 |
NEK2 |
0.727 | -0.074 | 2 | 0.661 |
PAK6 |
0.726 | -0.016 | -2 | 0.647 |
IRE2 |
0.726 | -0.078 | 2 | 0.563 |
MARK4 |
0.726 | -0.107 | 4 | 0.697 |
WNK3 |
0.726 | -0.237 | 1 | 0.436 |
YSK4 |
0.726 | -0.123 | 1 | 0.415 |
MEK1 |
0.723 | -0.127 | 2 | 0.661 |
PKCZ |
0.723 | -0.066 | 2 | 0.617 |
PKCG |
0.723 | -0.080 | 2 | 0.572 |
PLK1 |
0.723 | -0.117 | -2 | 0.748 |
PAK1 |
0.723 | -0.064 | -2 | 0.720 |
PAK3 |
0.723 | -0.081 | -2 | 0.717 |
PERK |
0.723 | -0.050 | -2 | 0.789 |
AMPKA1 |
0.722 | -0.121 | -3 | 0.738 |
PKACB |
0.722 | -0.009 | -2 | 0.630 |
NIM1 |
0.722 | -0.118 | 3 | 0.775 |
TSSK1 |
0.722 | -0.062 | -3 | 0.761 |
PRKD3 |
0.721 | -0.048 | -3 | 0.614 |
AKT2 |
0.721 | -0.006 | -3 | 0.552 |
AURB |
0.720 | -0.025 | -2 | 0.614 |
RIPK1 |
0.720 | -0.245 | 1 | 0.431 |
RSK4 |
0.720 | -0.038 | -3 | 0.634 |
TLK1 |
0.720 | -0.038 | -2 | 0.812 |
CAMK2B |
0.720 | -0.091 | 2 | 0.617 |
AURA |
0.719 | -0.021 | -2 | 0.597 |
MST3 |
0.719 | -0.039 | 2 | 0.706 |
NEK5 |
0.719 | -0.060 | 1 | 0.431 |
GRK2 |
0.719 | -0.069 | -2 | 0.662 |
SGK3 |
0.718 | -0.041 | -3 | 0.648 |
CHAK1 |
0.718 | -0.151 | 2 | 0.612 |
CAMK2A |
0.718 | -0.076 | 2 | 0.620 |
PKG2 |
0.718 | -0.041 | -2 | 0.619 |
CK1E |
0.717 | -0.031 | -3 | 0.489 |
PKCH |
0.717 | -0.095 | 2 | 0.551 |
MEKK1 |
0.717 | -0.130 | 1 | 0.438 |
PLK4 |
0.717 | -0.110 | 2 | 0.459 |
AMPKA2 |
0.717 | -0.099 | -3 | 0.700 |
TSSK2 |
0.716 | -0.128 | -5 | 0.761 |
MNK1 |
0.716 | -0.066 | -2 | 0.725 |
MSK2 |
0.716 | -0.087 | -3 | 0.641 |
PLK3 |
0.716 | -0.112 | 2 | 0.579 |
GSK3B |
0.716 | 0.022 | 4 | 0.362 |
ZAK |
0.716 | -0.136 | 1 | 0.421 |
HRI |
0.716 | -0.118 | -2 | 0.798 |
MEKK2 |
0.716 | -0.087 | 2 | 0.634 |
NUAK1 |
0.715 | -0.081 | -3 | 0.659 |
MEK5 |
0.714 | -0.149 | 2 | 0.653 |
PAK2 |
0.714 | -0.095 | -2 | 0.703 |
TAO3 |
0.714 | -0.060 | 1 | 0.461 |
CK1D |
0.714 | -0.007 | -3 | 0.440 |
MSK1 |
0.714 | -0.059 | -3 | 0.639 |
QSK |
0.713 | -0.092 | 4 | 0.687 |
CAMK4 |
0.713 | -0.176 | -3 | 0.688 |
DCAMKL1 |
0.712 | -0.067 | -3 | 0.657 |
WNK4 |
0.712 | -0.111 | -2 | 0.776 |
LKB1 |
0.711 | 0.015 | -3 | 0.786 |
MAPKAPK5 |
0.711 | -0.109 | -3 | 0.613 |
PIM2 |
0.711 | -0.036 | -3 | 0.614 |
BRAF |
0.711 | -0.115 | -4 | 0.777 |
PRKX |
0.711 | -0.023 | -3 | 0.547 |
MELK |
0.711 | -0.137 | -3 | 0.675 |
CK1G1 |
0.710 | -0.039 | -3 | 0.490 |
DRAK1 |
0.710 | -0.165 | 1 | 0.416 |
MEKK3 |
0.710 | -0.176 | 1 | 0.440 |
NEK11 |
0.710 | -0.121 | 1 | 0.448 |
PKCT |
0.710 | -0.082 | 2 | 0.566 |
BUB1 |
0.709 | 0.055 | -5 | 0.746 |
QIK |
0.709 | -0.178 | -3 | 0.715 |
MYLK4 |
0.708 | -0.089 | -2 | 0.712 |
CHK1 |
0.708 | -0.096 | -3 | 0.733 |
IRAK4 |
0.707 | -0.159 | 1 | 0.408 |
GAK |
0.707 | -0.045 | 1 | 0.485 |
PAK5 |
0.707 | -0.046 | -2 | 0.602 |
PASK |
0.707 | -0.081 | -3 | 0.779 |
GRK3 |
0.707 | -0.065 | -2 | 0.633 |
SIK |
0.706 | -0.108 | -3 | 0.621 |
PKCI |
0.706 | -0.066 | 2 | 0.591 |
NEK4 |
0.706 | -0.078 | 1 | 0.411 |
AKT1 |
0.706 | -0.036 | -3 | 0.574 |
NEK8 |
0.705 | -0.137 | 2 | 0.642 |
CK1A2 |
0.705 | -0.032 | -3 | 0.431 |
MEKK6 |
0.705 | -0.063 | 1 | 0.426 |
PDK1 |
0.705 | -0.081 | 1 | 0.461 |
TNIK |
0.705 | -0.020 | 3 | 0.830 |
PKACA |
0.704 | -0.028 | -2 | 0.587 |
PAK4 |
0.704 | -0.038 | -2 | 0.613 |
CAMKK2 |
0.704 | -0.066 | -2 | 0.664 |
MAP3K15 |
0.703 | -0.077 | 1 | 0.423 |
CK2A2 |
0.703 | -0.051 | 1 | 0.406 |
HGK |
0.703 | -0.050 | 3 | 0.833 |
GCK |
0.703 | -0.078 | 1 | 0.437 |
P70S6K |
0.703 | -0.060 | -3 | 0.578 |
MARK3 |
0.703 | -0.108 | 4 | 0.626 |
MARK2 |
0.702 | -0.119 | 4 | 0.601 |
MST2 |
0.702 | -0.109 | 1 | 0.431 |
TTBK1 |
0.702 | -0.165 | 2 | 0.464 |
CAMKK1 |
0.702 | -0.150 | -2 | 0.663 |
DCAMKL2 |
0.702 | -0.101 | -3 | 0.673 |
TAO2 |
0.702 | -0.108 | 2 | 0.676 |
PKCE |
0.702 | -0.051 | 2 | 0.562 |
BRSK2 |
0.702 | -0.148 | -3 | 0.687 |
EEF2K |
0.701 | -0.043 | 3 | 0.767 |
NEK1 |
0.701 | -0.065 | 1 | 0.413 |
AKT3 |
0.700 | -0.010 | -3 | 0.505 |
SNRK |
0.700 | -0.214 | 2 | 0.496 |
SMMLCK |
0.700 | -0.098 | -3 | 0.700 |
BRSK1 |
0.700 | -0.135 | -3 | 0.666 |
MINK |
0.699 | -0.095 | 1 | 0.410 |
PHKG2 |
0.699 | -0.133 | -3 | 0.649 |
CAMK1G |
0.699 | -0.129 | -3 | 0.622 |
HPK1 |
0.698 | -0.083 | 1 | 0.433 |
LOK |
0.698 | -0.076 | -2 | 0.679 |
PLK2 |
0.697 | -0.059 | -3 | 0.787 |
TAK1 |
0.696 | -0.156 | 1 | 0.428 |
OSR1 |
0.696 | -0.020 | 2 | 0.662 |
NEK3 |
0.695 | -0.053 | 1 | 0.412 |
DAPK3 |
0.695 | -0.077 | -3 | 0.671 |
KHS1 |
0.695 | -0.055 | 1 | 0.420 |
SGK1 |
0.695 | -0.017 | -3 | 0.485 |
PBK |
0.694 | -0.028 | 1 | 0.428 |
HASPIN |
0.694 | -0.026 | -1 | 0.461 |
YSK1 |
0.693 | -0.083 | 2 | 0.676 |
LRRK2 |
0.693 | -0.107 | 2 | 0.675 |
SSTK |
0.693 | -0.121 | 4 | 0.678 |
CK2A1 |
0.693 | -0.062 | 1 | 0.393 |
KHS2 |
0.693 | -0.048 | 1 | 0.435 |
PKN1 |
0.692 | -0.083 | -3 | 0.589 |
IRAK1 |
0.692 | -0.252 | -1 | 0.504 |
VRK1 |
0.692 | -0.182 | 2 | 0.654 |
MARK1 |
0.692 | -0.158 | 4 | 0.642 |
MEK2 |
0.692 | -0.147 | 2 | 0.648 |
SLK |
0.691 | -0.099 | -2 | 0.630 |
TTK |
0.691 | -0.028 | -2 | 0.781 |
CHK2 |
0.689 | -0.067 | -3 | 0.493 |
ROCK2 |
0.688 | -0.058 | -3 | 0.664 |
MST1 |
0.688 | -0.146 | 1 | 0.413 |
DAPK1 |
0.688 | -0.082 | -3 | 0.651 |
SBK |
0.687 | 0.025 | -3 | 0.434 |
MRCKB |
0.687 | -0.057 | -3 | 0.596 |
STK33 |
0.686 | -0.148 | 2 | 0.453 |
MYO3B |
0.686 | -0.044 | 2 | 0.682 |
BIKE |
0.685 | -0.027 | 1 | 0.424 |
CAMK1D |
0.685 | -0.107 | -3 | 0.543 |
PDHK3_TYR |
0.684 | 0.103 | 4 | 0.778 |
CRIK |
0.682 | -0.009 | -3 | 0.590 |
CK1A |
0.681 | -0.026 | -3 | 0.359 |
MRCKA |
0.681 | -0.083 | -3 | 0.620 |
AAK1 |
0.681 | 0.014 | 1 | 0.383 |
LIMK2_TYR |
0.681 | 0.106 | -3 | 0.816 |
MAP2K4_TYR |
0.680 | 0.063 | -1 | 0.601 |
MYO3A |
0.680 | -0.076 | 1 | 0.425 |
ASK1 |
0.680 | -0.118 | 1 | 0.424 |
RIPK2 |
0.679 | -0.244 | 1 | 0.396 |
CAMK1A |
0.678 | -0.084 | -3 | 0.519 |
PKG1 |
0.678 | -0.066 | -2 | 0.540 |
DMPK1 |
0.678 | -0.039 | -3 | 0.620 |
PDHK4_TYR |
0.677 | 0.022 | 2 | 0.699 |
PKMYT1_TYR |
0.677 | 0.069 | 3 | 0.852 |
ALPHAK3 |
0.677 | -0.098 | -1 | 0.521 |
MAP2K6_TYR |
0.677 | 0.026 | -1 | 0.596 |
TESK1_TYR |
0.676 | 0.003 | 3 | 0.863 |
TAO1 |
0.674 | -0.115 | 1 | 0.404 |
PDHK1_TYR |
0.673 | -0.046 | -1 | 0.593 |
TXK |
0.673 | -0.021 | 1 | 0.448 |
BMPR2_TYR |
0.673 | -0.037 | -1 | 0.579 |
ROCK1 |
0.673 | -0.073 | -3 | 0.614 |
ABL2 |
0.671 | -0.042 | -1 | 0.563 |
MAP2K7_TYR |
0.671 | -0.113 | 2 | 0.671 |
YANK3 |
0.671 | -0.083 | 2 | 0.301 |
CSF1R |
0.669 | -0.051 | 3 | 0.834 |
LCK |
0.669 | -0.033 | -1 | 0.581 |
JAK2 |
0.668 | -0.045 | 1 | 0.452 |
BLK |
0.668 | -0.028 | -1 | 0.582 |
ABL1 |
0.667 | -0.057 | -1 | 0.565 |
STLK3 |
0.667 | -0.143 | 1 | 0.400 |
RET |
0.667 | -0.114 | 1 | 0.451 |
EPHA6 |
0.666 | -0.097 | -1 | 0.573 |
PINK1_TYR |
0.666 | -0.168 | 1 | 0.504 |
ROS1 |
0.665 | -0.085 | 3 | 0.801 |
YES1 |
0.665 | -0.073 | -1 | 0.585 |
JAK1 |
0.665 | -0.019 | 1 | 0.409 |
EPHB4 |
0.665 | -0.110 | -1 | 0.539 |
MST1R |
0.664 | -0.108 | 3 | 0.838 |
TYRO3 |
0.664 | -0.119 | 3 | 0.816 |
LIMK1_TYR |
0.663 | -0.073 | 2 | 0.668 |
HCK |
0.663 | -0.098 | -1 | 0.576 |
FGR |
0.662 | -0.100 | 1 | 0.440 |
FER |
0.662 | -0.115 | 1 | 0.468 |
TYK2 |
0.662 | -0.138 | 1 | 0.434 |
TNNI3K_TYR |
0.660 | 0.024 | 1 | 0.457 |
NEK10_TYR |
0.660 | -0.060 | 1 | 0.396 |
JAK3 |
0.660 | -0.124 | 1 | 0.446 |
ITK |
0.660 | -0.106 | -1 | 0.541 |
KIT |
0.659 | -0.097 | 3 | 0.827 |
KDR |
0.658 | -0.075 | 3 | 0.802 |
SRMS |
0.658 | -0.121 | 1 | 0.446 |
FGFR2 |
0.657 | -0.077 | 3 | 0.820 |
FYN |
0.657 | -0.057 | -1 | 0.562 |
EPHA4 |
0.656 | -0.093 | 2 | 0.584 |
MET |
0.656 | -0.084 | 3 | 0.826 |
INSRR |
0.656 | -0.120 | 3 | 0.785 |
MERTK |
0.656 | -0.108 | 3 | 0.815 |
TNK2 |
0.655 | -0.100 | 3 | 0.788 |
TEC |
0.655 | -0.111 | -1 | 0.507 |
EPHB1 |
0.654 | -0.148 | 1 | 0.443 |
TEK |
0.654 | -0.071 | 3 | 0.768 |
BMX |
0.654 | -0.104 | -1 | 0.486 |
DDR1 |
0.653 | -0.150 | 4 | 0.696 |
CK1G3 |
0.653 | -0.046 | -3 | 0.313 |
TNK1 |
0.653 | -0.089 | 3 | 0.807 |
FGFR1 |
0.652 | -0.077 | 3 | 0.791 |
EPHB3 |
0.652 | -0.145 | -1 | 0.531 |
EPHB2 |
0.651 | -0.141 | -1 | 0.521 |
PDGFRB |
0.651 | -0.176 | 3 | 0.825 |
FLT1 |
0.649 | -0.122 | -1 | 0.528 |
FGFR3 |
0.649 | -0.082 | 3 | 0.799 |
AXL |
0.649 | -0.150 | 3 | 0.813 |
FRK |
0.648 | -0.124 | -1 | 0.581 |
LYN |
0.648 | -0.104 | 3 | 0.738 |
PTK2B |
0.648 | -0.075 | -1 | 0.555 |
PTK6 |
0.648 | -0.154 | -1 | 0.503 |
ALK |
0.647 | -0.136 | 3 | 0.757 |
FLT3 |
0.647 | -0.184 | 3 | 0.808 |
EPHA7 |
0.646 | -0.128 | 2 | 0.575 |
SRC |
0.646 | -0.091 | -1 | 0.566 |
MATK |
0.644 | -0.102 | -1 | 0.496 |
PDGFRA |
0.644 | -0.202 | 3 | 0.822 |
ERBB2 |
0.643 | -0.149 | 1 | 0.419 |
BTK |
0.643 | -0.219 | -1 | 0.519 |
NTRK3 |
0.643 | -0.122 | -1 | 0.503 |
YANK2 |
0.643 | -0.091 | 2 | 0.301 |
SYK |
0.643 | -0.064 | -1 | 0.503 |
LTK |
0.643 | -0.155 | 3 | 0.779 |
PTK2 |
0.642 | -0.066 | -1 | 0.506 |
WEE1_TYR |
0.642 | -0.125 | -1 | 0.493 |
EPHA1 |
0.642 | -0.152 | 3 | 0.809 |
EGFR |
0.642 | -0.097 | 1 | 0.371 |
EPHA8 |
0.640 | -0.115 | -1 | 0.517 |
FLT4 |
0.640 | -0.158 | 3 | 0.784 |
FGFR4 |
0.640 | -0.093 | -1 | 0.505 |
NTRK1 |
0.640 | -0.198 | -1 | 0.528 |
INSR |
0.640 | -0.145 | 3 | 0.760 |
CK1G2 |
0.640 | -0.049 | -3 | 0.405 |
NTRK2 |
0.638 | -0.189 | 3 | 0.785 |
DDR2 |
0.638 | -0.071 | 3 | 0.772 |
EPHA3 |
0.638 | -0.168 | 2 | 0.555 |
ZAP70 |
0.636 | -0.032 | -1 | 0.459 |
EPHA5 |
0.636 | -0.147 | 2 | 0.556 |
CSK |
0.635 | -0.139 | 2 | 0.581 |
EPHA2 |
0.633 | -0.120 | -1 | 0.482 |
ERBB4 |
0.632 | -0.086 | 1 | 0.381 |
IGF1R |
0.627 | -0.134 | 3 | 0.703 |
MUSK |
0.626 | -0.148 | 1 | 0.344 |
FES |
0.619 | -0.146 | -1 | 0.477 |