Motif 429 (n=321)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6H8Y1 | BDP1 | S292 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NCS6 | C2orf72 | S246 | ochoa | Uncharacterized protein C2orf72 | None |
| A7E2V4 | ZSWIM8 | S1265 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| A8MT19 | RHPN2P1 | S495 | ochoa | Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) | None |
| E9PCH4 | None | S1143 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O00443 | PIK3C2A | S59 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O14595 | CTDSP2 | S54 | ochoa | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2) | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. |
| O14777 | NDC80 | S75 | ochoa|psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15014 | ZNF609 | S452 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15534 | PER1 | S809 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43314 | PPIP5K2 | S1073 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43482 | OIP5 | S47 | ochoa | Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
| O60343 | TBC1D4 | S569 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60664 | PLIN3 | S374 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60701 | UGDH | S349 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O60814 | H2BC12 | Y38 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O75179 | ANKRD17 | S1566 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75369 | FLNB | S1528 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O76061 | STC2 | S250 | ochoa | Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) | Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
| O94880 | PHF14 | S571 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94956 | SLCO2B1 | S687 | ochoa | Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9) | Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:26383540, PubMed:27576593, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, PubMed:29871943, Ref.25). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:14610227, ECO:0000269|PubMed:16908597, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20507927, ECO:0000269|PubMed:22201122, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:27576593, ECO:0000269|PubMed:29871943, ECO:0000269|PubMed:34628357, ECO:0000269|PubMed:35714613, ECO:0000269|Ref.25, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 3]: Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1. {ECO:0000269|PubMed:23531488}. |
| O94979 | SEC31A | S351 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95071 | UBR5 | S1701 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95239 | KIF4A | S886 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95999 | BCL10 | S170 | psp | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| O96028 | NSD2 | S55 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P04637 | TP53 | S366 | psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P05165 | PCCA | S251 | ochoa | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:8434582). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:10101253, PubMed:6765947, PubMed:8434582). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P0DTA4, ECO:0000250|UniProtKB:Q5LUF3, ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:6765947, ECO:0000269|PubMed:8434582}. |
| P05549 | TFAP2A | S222 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P07737 | PFN1 | S57 | ochoa | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| P0C0S8 | H2AC11 | S19 | ochoa | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P11055 | MYH3 | S643 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12429 | ANXA3 | S145 | ochoa | Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) | Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. |
| P12882 | MYH1 | S646 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S642 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S644 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S645 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14416 | DRD2 | S228 | psp | D(2) dopamine receptor (Dopamine D2 receptor) | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000269|PubMed:21645528}. |
| P16104 | H2AX | S19 | ochoa | Histone H2AX (H2a/x) (Histone H2A.X) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}. |
| P17098 | ZNF8 | S354 | ochoa | Zinc finger protein 8 (Zinc finger protein HF.18) | Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}. |
| P18031 | PTPN1 | S242 | psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P20671 | H2AC7 | S19 | ochoa | Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P23508 | MCC | S316 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P25100 | ADRA1D | S331 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P25116 | F2R | S395 | ochoa | Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) | High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (PubMed:10079109). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed:30568593, PubMed:34831181). {ECO:0000250|UniProtKB:P26824, ECO:0000250|UniProtKB:P30558, ECO:0000269|PubMed:10079109, ECO:0000269|PubMed:1672265, ECO:0000269|PubMed:30568593, ECO:0000269|PubMed:34831181, ECO:0000269|PubMed:8136362}. |
| P28715 | ERCC5 | S1067 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P30086 | PEBP1 | S98 | ochoa | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P30305 | CDC25B | S229 | ochoa | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30405 | PPIF | S39 | ochoa | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}. |
| P34972 | CNR2 | S335 | ochoa|psp | Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5) | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}. |
| P35670 | ATP7B | S340 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
| P35749 | MYH11 | S637 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1719 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38398 | BRCA1 | S1496 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40925 | MDH1 | S188 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P42566 | EPS15 | S745 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46939 | UTRN | S829 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P46939 | UTRN | S1865 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P46940 | IQGAP1 | S481 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P48444 | ARCN1 | S252 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P49368 | CCT3 | S243 | ochoa | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49902 | NT5C2 | S417 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P51948 | MNAT1 | S189 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P54252 | ATXN3 | S260 | psp | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P54296 | MYOM2 | S58 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55008 | AIF1 | S38 | ochoa | Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1) | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:15117732, ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}. |
| P55196 | AFDN | S1082 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P57053 | H2BC12L | Y38 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | Y38 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P61129 | ZC3H6 | S187 | ochoa | Zinc finger CCCH domain-containing protein 6 | None |
| P61764 | STXBP1 | S506 | ochoa | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P61925 | PKIA | S29 | ochoa | cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) | Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. |
| P62807 | H2BC4 | Y38 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P81274 | GPSM2 | S524 | ochoa | G-protein-signaling modulator 2 (Mosaic protein LGN) | Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}. |
| P98171 | ARHGAP4 | S216 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q00587 | CDC42EP1 | S25 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q00610 | CLTC | S146 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q01105 | SET | S183 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01831 | XPC | S346 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q01850 | CDR2 | S310 | ochoa | Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) | None |
| Q02388 | COL7A1 | S1966 | ochoa | Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Q02641 | CACNB1 | S191 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q03001 | DST | S1692 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03014 | HHEX | S213 | ochoa | Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein) | Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). {ECO:0000250|UniProtKB:P43120, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:20028982, ECO:0000269|PubMed:8096636}. |
| Q03188 | CENPC | S126 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03188 | CENPC | S195 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q05209 | PTPN12 | S397 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07065 | CKAP4 | S460 | ochoa | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) | Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}. |
| Q08170 | SRSF4 | S112 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q12802 | AKAP13 | S1856 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12830 | BPTF | S2239 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12929 | EPS8 | S57 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q12929 | EPS8 | S480 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13009 | TIAM1 | S59 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13085 | ACACA | S77 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13148 | TARDBP | S91 | ochoa|psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13243 | SRSF5 | S116 | ochoa | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. |
| Q13247 | SRSF6 | S118 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13303 | KCNAB2 | S111 | ochoa | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}. |
| Q13308 | PTK7 | S794 | ochoa | Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}. |
| Q13393 | PLD1 | S610 | psp | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13415 | ORC1 | S345 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13439 | GOLGA4 | S97 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q13480 | GAB1 | S418 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13561 | DCTN2 | S202 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q13586 | STIM1 | S400 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q13772 | NCOA4 | S553 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q14126 | DSG2 | S699 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14126 | DSG2 | S886 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14161 | GIT2 | S360 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14161 | GIT2 | S499 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14202 | ZMYM3 | S1054 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14244 | MAP7 | S282 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14694 | USP10 | S27 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14722 | KCNAB1 | S163 | ochoa | Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels (PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988, PubMed:7649300, PubMed:7890764, PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:9763623}.; FUNCTION: [Isoform KvB1.2]: Isoform KvB1.2 shows no effect on KCNA1, KCNA2 or KCNB1. {ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764}. |
| Q15111 | PLCL1 | S76 | ochoa | Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}. |
| Q15139 | PRKD1 | S548 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15424 | SAFB | S414 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15637 | SF1 | S267 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q15746 | MYLK | S1122 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q15776 | ZKSCAN8 | S37 | ochoa | Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) | May be involved in transcriptional regulation. |
| Q15785 | TOMM34 | S279 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q16533 | SNAPC1 | S289 | ochoa | snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}. |
| Q16555 | DPYSL2 | S427 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q16777 | H2AC20 | S19 | ochoa | Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q16778 | H2BC21 | Y38 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q16891 | IMMT | S583 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q17RS7 | GEN1 | S801 | ochoa | Flap endonuclease GEN homolog 1 (EC 3.1.-.-) | Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850). Also has endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604). {ECO:0000269|PubMed:19020614, ECO:0000269|PubMed:26578604, ECO:0000269|PubMed:26682650, ECO:0000269|PubMed:28049850}. |
| Q2KJY2 | KIF26B | S269 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2LD37 | BLTP1 | S1681 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q4KMP7 | TBC1D10B | S657 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q56NI9 | ESCO2 | S222 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
| Q5JSH3 | WDR44 | S161 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5JTJ3 | COA6 | S84 | ochoa | Cytochrome c oxidase assembly factor 6 homolog | Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. {ECO:0000269|PubMed:24549041, ECO:0000269|PubMed:25959673, ECO:0000269|PubMed:26160915}. |
| Q5QNW6 | H2BC18 | Y38 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5SSJ5 | HP1BP3 | S248 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5SW79 | CEP170 | S724 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T0W9 | FAM83B | S542 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T1R4 | HIVEP3 | S804 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5THJ4 | VPS13D | S2434 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S1189 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1706 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VTT5 | MYOM3 | S240 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q5VZ89 | DENND4C | S908 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q676U5 | ATG16L1 | S289 | ochoa|psp | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q68EM7 | ARHGAP17 | S161 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q69YH5 | CDCA2 | S665 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6DN03 | H2BC20P | Y38 | ochoa | Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DRA6 | H2BC19P | Y38 | ochoa | Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6FI13 | H2AC18 | S19 | ochoa | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6IAA8 | LAMTOR1 | S97 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6P9G4 | TMEM154 | S111 | ochoa | Transmembrane protein 154 | None |
| Q6PFW1 | PPIP5K1 | S1036 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6SZW1 | SARM1 | S703 | ochoa | NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439792, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). {ECO:0000250|UniProtKB:Q6PDS3, ECO:0000269|PubMed:15123841, ECO:0000269|PubMed:16964262, ECO:0000269|PubMed:20306472, ECO:0000269|PubMed:25908823, ECO:0000269|PubMed:27671644, ECO:0000269|PubMed:28334607, ECO:0000269|PubMed:29395922, ECO:0000269|PubMed:30333228, ECO:0000269|PubMed:31128467, ECO:0000269|PubMed:31439792, ECO:0000269|PubMed:31439793, ECO:0000269|PubMed:32049506, ECO:0000269|PubMed:32828421, ECO:0000269|PubMed:33053563}. |
| Q6VUC0 | TFAP2E | S229 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
| Q6W2J9 | BCOR | S1404 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6XZF7 | DNMBP | S482 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6Y2X3 | DNAJC14 | S187 | ochoa | DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3) | Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}. |
| Q6ZU35 | CRACD | S542 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZWJ1 | STXBP4 | S163 | ochoa | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
| Q70EL1 | USP54 | S1250 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q71F56 | MED13L | S1642 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q7L576 | CYFIP1 | S582 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7L804 | RAB11FIP2 | S184 | ochoa | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}. |
| Q7Z3S7 | CACNA2D4 | S498 | ochoa | Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}. |
| Q7Z417 | NUFIP2 | S607 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z494 | NPHP3 | S1307 | ochoa | Nephrocystin-3 | Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. {ECO:0000269|PubMed:18371931}. |
| Q7Z6R9 | TFAP2D | S222 | ochoa | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}. |
| Q7Z6Z7 | HUWE1 | S3261 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7B0 | FILIP1 | S937 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q86SQ0 | PHLDB2 | S347 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UE4 | MTDH | S532 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86W34 | AMZ2 | S226 | ochoa | Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) | Probable zinc metalloprotease. {ECO:0000250|UniProtKB:Q8TXW1}. |
| Q86W92 | PPFIBP1 | S465 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q86WP2 | GPBP1 | S380 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q86Z02 | HIPK1 | S37 | ochoa | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q8IUC4 | RHPN2 | S598 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8IUE6 | H2AC21 | S19 | ochoa | Histone H2A type 2-B (H2A-clustered histone 21) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8IWS0 | PHF6 | S54 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IX90 | SKA3 | S317 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8IXK0 | PHC2 | S590 | ochoa | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Q8IY57 | YAF2 | S111 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8N122 | RPTOR | S854 | ochoa | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N201 | INTS1 | S81 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q8N257 | H2BC26 | Y38 | ochoa | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8N3C7 | CLIP4 | S432 | ochoa | CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) | None |
| Q8N5C8 | TAB3 | S356 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N8E3 | CEP112 | S241 | ochoa | Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) | None |
| Q8NC51 | SERBP1 | S202 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NCN4 | RNF169 | S471 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NDX5 | PHC3 | S228 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEM0 | MCPH1 | S101 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NFY9 | KBTBD8 | S346 | ochoa | Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}. |
| Q8NG31 | KNL1 | S1085 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TAT6 | NPLOC4 | S59 | ochoa | Nuclear protein localization protein 4 homolog (Protein NPL4) | The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}. |
| Q8TCG1 | CIP2A | S572 | ochoa | Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) | Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). {ECO:0000269|PubMed:17632056, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}. |
| Q8TEU7 | RAPGEF6 | S1093 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TEW0 | PARD3 | S143 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WWI1 | LMO7 | S1204 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WY36 | BBX | S885 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q92481 | TFAP2B | S241 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
| Q92598 | HSPH1 | S509 | ochoa | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q92622 | RUBCN | S387 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q92754 | TFAP2C | S235 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
| Q92785 | DPF2 | S117 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92859 | NEO1 | S802 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q93077 | H2AC6 | S19 | ochoa | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93079 | H2BC9 | Y38 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96AQ6 | PBXIP1 | S550 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96B33 | CLDN23 | S203 | ochoa | Claudin-23 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}. |
| Q96BT3 | CENPT | S183 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96DY7 | MTBP | S755 | ochoa | Mdm2-binding protein (hMTBP) | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}. |
| Q96EY5 | MVB12A | S207 | ochoa|psp | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96F07 | CYFIP2 | S606 | ochoa | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}. |
| Q96F86 | EDC3 | S109 | ochoa|psp | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96HH9 | GRAMD2B | S71 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96J84 | KIRREL1 | S573 | psp | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}. |
| Q96K76 | USP47 | S963 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96KK5 | H2AC12 | S19 | ochoa | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96KN1 | LRATD2 | S178 | ochoa | Protein LRATD2 (Breast cancer membrane protein 101) (LRAT domain-containing 2) (Protein FAM84B) (Protein NSE2) | None |
| Q96KR1 | ZFR | S475 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96L73 | NSD1 | S571 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96MY1 | NOL4L | S294 | ochoa | Nucleolar protein 4-like | None |
| Q96P11 | NSUN5 | S166 | ochoa | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}. |
| Q96PE2 | ARHGEF17 | S1330 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96S59 | RANBP9 | S534 | ochoa | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q96ST8 | CEP89 | S113 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q99569 | PKP4 | S388 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99570 | PIK3R4 | S813 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99570 | PIK3R4 | S894 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99570 | PIK3R4 | S925 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99590 | SCAF11 | S1169 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99877 | H2BC15 | Y38 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99878 | H2AC14 | S19 | ochoa | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | Y38 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | Y38 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BPZ3 | PAIP2 | S100 | ochoa | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. {ECO:0000269|PubMed:11172725}. |
| Q9BSF8 | BTBD10 | S74 | ochoa | BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) | Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. {ECO:0000250|UniProtKB:Q80X66}. |
| Q9BVI0 | PHF20 | S158 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BVJ6 | UTP14A | S77 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW04 | SARG | S35 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BX63 | BRIP1 | S1003 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BZ67 | FRMD8 | S20 | ochoa | FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. |
| Q9BZ68 | FRMD8P1 | S20 | ochoa | Putative FERM domain-containing protein FRMD8P1 (FERM domain-containing 8 pseudogene 1) | None |
| Q9C0C2 | TNKS1BP1 | S962 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D2 | CEP295 | S2023 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9C0D5 | TANC1 | S609 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9GZV5 | WWTR1 | S173 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H0H5 | RACGAP1 | S169 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H0K1 | SIK2 | S342 | ochoa | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H201 | EPN3 | S505 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H2P0 | ADNP | S874 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H3P7 | ACBD3 | S315 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9H6Z4 | RANBP3 | S125 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H967 | WDR76 | S113 | ochoa | WD repeat-containing protein 76 | Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000250}. |
| Q9H9A7 | RMI1 | S274 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9H9H4 | VPS37B | S98 | ochoa | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}. |
| Q9HC78 | ZBTB20 | S224 | ochoa | Zinc finger and BTB domain-containing protein 20 (Dendritic-derived BTB/POZ zinc finger protein) (Zinc finger protein 288) | May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q8K0L9, ECO:0000269|PubMed:11352661}. |
| Q9HCD5 | NCOA5 | S377 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCH5 | SYTL2 | S321 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCP0 | CSNK1G1 | S31 | ochoa | Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}. |
| Q9NP62 | GCM1 | S177 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NQT8 | KIF13B | S1293 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NR09 | BIRC6 | S461 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NR09 | BIRC6 | S2221 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NRY4 | ARHGAP35 | S769 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NSK0 | KLC4 | S565 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NTM9 | CUTC | S238 | ochoa | Copper homeostasis protein cutC homolog | May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. {ECO:0000269|PubMed:16182249, ECO:0000269|PubMed:19878721}. |
| Q9NWH9 | SLTM | S788 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NXF1 | TEX10 | S292 | ochoa | Testis-expressed protein 10 | Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). {ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q9NZI5 | GRHL1 | S76 | ochoa|psp | Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32) | Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). May play a role in regulating glucose homeostasis and insulin signaling. {ECO:0000250|UniProtKB:Q921D9, ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:18288204, ECO:0000269|PubMed:29309642, ECO:0000269|PubMed:35013237}.; FUNCTION: [Isoform 1]: Functions as a transcription activator. {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:29309642}.; FUNCTION: [Isoform 2]: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. {ECO:0000269|PubMed:12175488}. |
| Q9NZJ0 | DTL | S557 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9NZV1 | CRIM1 | S980 | ochoa | Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] | May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}. |
| Q9P0J7 | KCMF1 | S219 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P0M6 | MACROH2A2 | S341 | ochoa | Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}. |
| Q9P0U3 | SENP1 | S107 | ochoa | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
| Q9P0W2 | HMG20B | S160 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35) | Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. |
| Q9P1T7 | MDFIC | S137 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Q9P246 | STIM2 | S343 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P2B7 | CFAP97 | S329 | ochoa | Cilia- and flagella-associated protein 97 | None |
| Q9UBD5 | ORC3 | S207 | ochoa | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:31160578}. |
| Q9UBU7 | DBF4 | S259 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UJF2 | RASAL2 | S829 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UJY4 | GGA2 | S326 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9UK61 | TASOR | S1551 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKA2 | FBXL4 | S267 | ochoa | F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) | Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors (PubMed:36896912, PubMed:38992176). Rescues also mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission (By similarity). {ECO:0000250|UniProtKB:Q8BH70, ECO:0000269|PubMed:36896912, ECO:0000269|PubMed:38992176}. |
| Q9UKX2 | MYH2 | S648 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULD2 | MTUS1 | S773 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULH0 | KIDINS220 | S1740 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULJ3 | ZBTB21 | S284 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULJ3 | ZBTB21 | S460 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULL8 | SHROOM4 | S154 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9ULT8 | HECTD1 | S1570 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMZ2 | SYNRG | S785 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UNZ2 | NSFL1C | S59 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UQM7 | CAMK2A | S330 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y266 | NUDC | S259 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y2I8 | WDR37 | S30 | ochoa | WD repeat-containing protein 37 | Required for normal ER Ca2+ handling in lymphocytes. Together with PACS1, it plays an essential role in stabilizing peripheral lymphocyte populations. {ECO:0000250|UniProtKB:Q8CBE3}. |
| Q9Y2Y0 | ARL2BP | S140 | ochoa | ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1) | Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. {ECO:0000269|PubMed:18234692}. |
| Q9Y426 | C2CD2 | S474 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y4D8 | HECTD4 | S1138 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4D8 | HECTD4 | S1715 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4G8 | RAPGEF2 | S959 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y520 | PRRC2C | S1544 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5B6 | PAXBP1 | S154 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y5X1 | SNX9 | S197 | ochoa | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q9Y5X1 | SNX9 | S198 | ochoa | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q9Y623 | MYH4 | S646 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y657 | SPIN1 | S38 | ochoa | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| Q9Y6B7 | AP4B1 | S592 | ochoa | AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9Y6D5 | ARFGEF2 | S276 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| R4GMW8 | BIVM-ERCC5 | S1521 | ochoa | DNA excision repair protein ERCC-5 | None |
| O43715 | TRIAP1 | S32 | Sugiyama | TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV) | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759, ECO:0000269|PubMed:26071602}. |
| P54578 | USP14 | S431 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| Q99798 | ACO2 | S388 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| Q6IBS0 | TWF2 | S139 | Sugiyama | Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}. |
| P06899 | H2BC11 | Y38 | Sugiyama | Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P23527 | H2BC17 | Y38 | Sugiyama | Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P33778 | H2BC3 | Y38 | Sugiyama | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P29320 | EPHA3 | S938 | Sugiyama | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| O43399 | TPD52L2 | S103 | Sugiyama | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-171306 | Packaging Of Telomere Ends | 1.110223e-16 | 15.955 |
| R-HSA-5334118 | DNA methylation | 1.110223e-16 | 15.955 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.110223e-16 | 15.955 |
| R-HSA-774815 | Nucleosome assembly | 1.110223e-16 | 15.955 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.110223e-16 | 15.955 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.110223e-16 | 15.955 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.110223e-16 | 15.955 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.110223e-16 | 15.955 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.110223e-16 | 15.955 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.110223e-16 | 15.955 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.110223e-16 | 15.955 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.110223e-16 | 15.955 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.110223e-16 | 15.955 |
| R-HSA-1221632 | Meiotic synapsis | 1.110223e-16 | 15.955 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.110223e-16 | 15.955 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.110223e-16 | 15.955 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.110223e-16 | 15.955 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.110223e-16 | 15.955 |
| R-HSA-912446 | Meiotic recombination | 1.110223e-16 | 15.955 |
| R-HSA-9710421 | Defective pyroptosis | 1.110223e-16 | 15.955 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.110223e-16 | 15.955 |
| R-HSA-73927 | Depurination | 1.110223e-16 | 15.955 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.110223e-16 | 15.955 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.110223e-16 | 15.955 |
| R-HSA-73928 | Depyrimidination | 1.110223e-16 | 15.955 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.110223e-16 | 15.955 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.220446e-16 | 15.654 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.330669e-16 | 15.477 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.330669e-16 | 15.477 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.661338e-16 | 15.176 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.221245e-15 | 14.913 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.776357e-15 | 14.750 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.998401e-15 | 14.699 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.220446e-15 | 14.654 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.330669e-15 | 14.477 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.994405e-15 | 14.155 |
| R-HSA-9645723 | Diseases of programmed cell death | 9.103829e-15 | 14.041 |
| R-HSA-3214847 | HATs acetylate histones | 1.010303e-14 | 13.996 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.076916e-14 | 13.968 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.143530e-14 | 13.942 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.421085e-14 | 13.847 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.632028e-14 | 13.787 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.632028e-14 | 13.787 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.709743e-14 | 13.767 |
| R-HSA-977225 | Amyloid fiber formation | 2.009504e-14 | 13.697 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.231548e-14 | 13.651 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.786660e-14 | 13.555 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.842171e-14 | 13.546 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.474998e-14 | 13.459 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.674838e-14 | 13.435 |
| R-HSA-1500620 | Meiosis | 4.485301e-14 | 13.348 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.340173e-14 | 13.272 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.605827e-14 | 13.180 |
| R-HSA-73886 | Chromosome Maintenance | 6.672440e-14 | 13.176 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.639799e-13 | 12.785 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.669775e-13 | 12.777 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.680078e-13 | 12.572 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.782219e-13 | 12.556 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.442935e-13 | 12.128 |
| R-HSA-73884 | Base Excision Repair | 1.376121e-12 | 11.861 |
| R-HSA-69481 | G2/M Checkpoints | 1.486256e-12 | 11.828 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.620704e-12 | 11.790 |
| R-HSA-9610379 | HCMV Late Events | 1.772360e-12 | 11.751 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.830647e-12 | 11.737 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.301936e-12 | 11.638 |
| R-HSA-1474165 | Reproduction | 2.533862e-12 | 11.596 |
| R-HSA-68875 | Mitotic Prophase | 3.911538e-12 | 11.408 |
| R-HSA-157579 | Telomere Maintenance | 6.035616e-12 | 11.219 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.912093e-12 | 11.050 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.008649e-11 | 10.697 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.008649e-11 | 10.697 |
| R-HSA-5688426 | Deubiquitination | 2.518064e-11 | 10.599 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.219469e-11 | 10.492 |
| R-HSA-211000 | Gene Silencing by RNA | 3.078171e-11 | 10.512 |
| R-HSA-69306 | DNA Replication | 5.047807e-11 | 10.297 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.424106e-11 | 10.192 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.424106e-11 | 10.192 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.424106e-11 | 10.192 |
| R-HSA-4839726 | Chromatin organization | 7.898748e-11 | 10.102 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.959833e-11 | 10.099 |
| R-HSA-73894 | DNA Repair | 1.095446e-10 | 9.960 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.184386e-10 | 9.927 |
| R-HSA-5693538 | Homology Directed Repair | 1.714614e-10 | 9.766 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.191266e-10 | 9.496 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.537577e-10 | 9.451 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.292190e-10 | 9.367 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.292190e-10 | 9.367 |
| R-HSA-2559583 | Cellular Senescence | 8.236967e-10 | 9.084 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.884963e-09 | 8.725 |
| R-HSA-1500931 | Cell-Cell communication | 2.108821e-09 | 8.676 |
| R-HSA-421270 | Cell-cell junction organization | 2.181120e-09 | 8.661 |
| R-HSA-446728 | Cell junction organization | 3.211607e-09 | 8.493 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.308705e-09 | 8.480 |
| R-HSA-418990 | Adherens junctions interactions | 4.161509e-09 | 8.381 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.620671e-09 | 8.118 |
| R-HSA-9609646 | HCMV Infection | 9.278203e-09 | 8.033 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.190461e-08 | 7.924 |
| R-HSA-9609690 | HCMV Early Events | 1.663548e-08 | 7.779 |
| R-HSA-1640170 | Cell Cycle | 3.224244e-08 | 7.492 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.904851e-08 | 7.309 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.032178e-08 | 7.044 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.066033e-07 | 6.972 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.180184e-07 | 6.928 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.428018e-07 | 6.845 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.965311e-07 | 6.707 |
| R-HSA-68886 | M Phase | 3.222821e-07 | 6.492 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.010685e-07 | 6.154 |
| R-HSA-157118 | Signaling by NOTCH | 1.488179e-06 | 5.827 |
| R-HSA-195721 | Signaling by WNT | 2.456364e-06 | 5.610 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.659261e-06 | 5.575 |
| R-HSA-8852135 | Protein ubiquitination | 2.702550e-06 | 5.568 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.601739e-06 | 5.443 |
| R-HSA-8939211 | ESR-mediated signaling | 4.769127e-06 | 5.322 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 7.678976e-06 | 5.115 |
| R-HSA-5689603 | UCH proteinases | 5.649734e-04 | 3.248 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.245533e-04 | 3.140 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.160141e-04 | 3.088 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.048413e-03 | 2.979 |
| R-HSA-9834899 | Specification of the neural plate border | 1.973060e-03 | 2.705 |
| R-HSA-212436 | Generic Transcription Pathway | 2.376736e-03 | 2.624 |
| R-HSA-74160 | Gene expression (Transcription) | 3.197058e-03 | 2.495 |
| R-HSA-1280218 | Adaptive Immune System | 3.332613e-03 | 2.477 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 3.418043e-03 | 2.466 |
| R-HSA-6804754 | Regulation of TP53 Expression | 3.518748e-03 | 2.454 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 3.660252e-03 | 2.436 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 5.420462e-03 | 2.266 |
| R-HSA-199991 | Membrane Trafficking | 6.209260e-03 | 2.207 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 6.250002e-03 | 2.204 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 7.303005e-03 | 2.136 |
| R-HSA-9615710 | Late endosomal microautophagy | 7.423656e-03 | 2.129 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 7.695520e-03 | 2.114 |
| R-HSA-9008059 | Interleukin-37 signaling | 8.171861e-03 | 2.088 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 8.454798e-03 | 2.073 |
| R-HSA-196780 | Biotin transport and metabolism | 8.454798e-03 | 2.073 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 8.455971e-03 | 2.073 |
| R-HSA-1266738 | Developmental Biology | 9.097359e-03 | 2.041 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.106216e-02 | 1.956 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.109580e-02 | 1.955 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.070778e-02 | 1.970 |
| R-HSA-2262752 | Cellular responses to stress | 1.112882e-02 | 1.954 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.165385e-02 | 1.934 |
| R-HSA-597592 | Post-translational protein modification | 1.294657e-02 | 1.888 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.329924e-02 | 1.876 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.575374e-02 | 1.803 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.659604e-02 | 1.780 |
| R-HSA-983189 | Kinesins | 1.693965e-02 | 1.771 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.693965e-02 | 1.771 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.752971e-02 | 1.756 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.752971e-02 | 1.756 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.752971e-02 | 1.756 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.752971e-02 | 1.756 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.845490e-02 | 1.734 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 2.020240e-02 | 1.695 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.049488e-02 | 1.688 |
| R-HSA-9723907 | Loss of Function of TP53 in Cancer | 2.137969e-02 | 1.670 |
| R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 2.137969e-02 | 1.670 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.140322e-02 | 1.670 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 2.410366e-02 | 1.618 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.828565e-02 | 1.548 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 2.828565e-02 | 1.548 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 3.273464e-02 | 1.485 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.043928e-02 | 1.517 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.559753e-02 | 1.449 |
| R-HSA-5689877 | Josephin domain DUBs | 3.273464e-02 | 1.485 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.015761e-02 | 1.521 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.093858e-02 | 1.509 |
| R-HSA-397014 | Muscle contraction | 3.127423e-02 | 1.505 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.111294e-02 | 1.507 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.296549e-02 | 1.482 |
| R-HSA-9612973 | Autophagy | 3.726310e-02 | 1.429 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.844616e-02 | 1.415 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.034674e-02 | 1.394 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.117590e-02 | 1.385 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.117590e-02 | 1.385 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 4.230358e-02 | 1.374 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 4.230358e-02 | 1.374 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 4.230358e-02 | 1.374 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.373869e-02 | 1.359 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.412038e-02 | 1.355 |
| R-HSA-162582 | Signal Transduction | 4.457296e-02 | 1.351 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.633829e-02 | 1.334 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.633829e-02 | 1.334 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.716694e-02 | 1.326 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.081073e-02 | 1.294 |
| R-HSA-177929 | Signaling by EGFR | 5.148114e-02 | 1.288 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 5.294205e-02 | 1.276 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 6.278136e-02 | 1.202 |
| R-HSA-390522 | Striated Muscle Contraction | 5.690682e-02 | 1.245 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.690682e-02 | 1.245 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.499631e-02 | 1.260 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.499631e-02 | 1.260 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.701739e-02 | 1.244 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 6.034894e-02 | 1.219 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 6.751743e-02 | 1.171 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.356149e-02 | 1.271 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 5.853584e-02 | 1.233 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 5.853584e-02 | 1.233 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 6.034894e-02 | 1.219 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 7.029413e-02 | 1.153 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.388634e-02 | 1.195 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.356149e-02 | 1.271 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.356149e-02 | 1.271 |
| R-HSA-5578768 | Physiological factors | 5.853584e-02 | 1.233 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.478167e-02 | 1.126 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 7.505402e-02 | 1.125 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 7.643741e-02 | 1.117 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 7.643741e-02 | 1.117 |
| R-HSA-1483148 | Synthesis of PG | 7.643741e-02 | 1.117 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.845362e-02 | 1.105 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 7.895605e-02 | 1.103 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 8.125628e-02 | 1.090 |
| R-HSA-9827857 | Specification of primordial germ cells | 8.274326e-02 | 1.082 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 8.274326e-02 | 1.082 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 8.294486e-02 | 1.081 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.417249e-02 | 1.026 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 9.502418e-02 | 1.022 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 9.580413e-02 | 1.019 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 9.580413e-02 | 1.019 |
| R-HSA-8865999 | MET activates PTPN11 | 1.024363e-01 | 0.990 |
| R-HSA-373753 | Nephrin family interactions | 1.025407e-01 | 0.989 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.025407e-01 | 0.989 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.085941e-01 | 0.964 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.089336e-01 | 0.963 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.119280e-01 | 0.951 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.131368e-01 | 0.946 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.131368e-01 | 0.946 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.131368e-01 | 0.946 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.131368e-01 | 0.946 |
| R-HSA-9675135 | Diseases of DNA repair | 1.131368e-01 | 0.946 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.216318e-01 | 0.915 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.404180e-01 | 0.853 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.234714e-01 | 0.908 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.602888e-01 | 0.795 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 1.678779e-01 | 0.775 |
| R-HSA-72187 | mRNA 3'-end processing | 1.418150e-01 | 0.848 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.234714e-01 | 0.908 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.177506e-01 | 0.929 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.368763e-01 | 0.864 |
| R-HSA-8849472 | PTK6 Down-Regulation | 1.404180e-01 | 0.853 |
| R-HSA-420029 | Tight junction interactions | 1.453159e-01 | 0.838 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 1.216318e-01 | 0.915 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 1.216318e-01 | 0.915 |
| R-HSA-437239 | Recycling pathway of L1 | 1.177506e-01 | 0.929 |
| R-HSA-390651 | Dopamine receptors | 1.216318e-01 | 0.915 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 1.404180e-01 | 0.853 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.270435e-01 | 0.896 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.270435e-01 | 0.896 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 1.216318e-01 | 0.915 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.239482e-01 | 0.907 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.177506e-01 | 0.929 |
| R-HSA-6806834 | Signaling by MET | 1.250823e-01 | 0.903 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.703187e-01 | 0.769 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.631581e-01 | 0.787 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.177835e-01 | 0.929 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.234714e-01 | 0.908 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.453159e-01 | 0.838 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.527660e-01 | 0.816 |
| R-HSA-73893 | DNA Damage Bypass | 1.271835e-01 | 0.896 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.588035e-01 | 0.799 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.208886e-01 | 0.918 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.304296e-01 | 0.885 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.453159e-01 | 0.838 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.621368e-01 | 0.790 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.463397e-01 | 0.835 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 1.306615e-01 | 0.884 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.602888e-01 | 0.795 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.163826e-01 | 0.934 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.602888e-01 | 0.795 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.527660e-01 | 0.816 |
| R-HSA-9824446 | Viral Infection Pathways | 1.636085e-01 | 0.786 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.520510e-01 | 0.818 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.767524e-01 | 0.753 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.767969e-01 | 0.753 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.767969e-01 | 0.753 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.809963e-01 | 0.742 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.832304e-01 | 0.737 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.832304e-01 | 0.737 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.832304e-01 | 0.737 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.832304e-01 | 0.737 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.832672e-01 | 0.737 |
| R-HSA-69206 | G1/S Transition | 1.883200e-01 | 0.725 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.886609e-01 | 0.724 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.944064e-01 | 0.711 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.944064e-01 | 0.711 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 2.116404e-01 | 0.674 |
| R-HSA-196025 | Formation of annular gap junctions | 2.116404e-01 | 0.674 |
| R-HSA-8875656 | MET receptor recycling | 2.116404e-01 | 0.674 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 2.116404e-01 | 0.674 |
| R-HSA-170984 | ARMS-mediated activation | 2.285067e-01 | 0.641 |
| R-HSA-9613354 | Lipophagy | 2.285067e-01 | 0.641 |
| R-HSA-190873 | Gap junction degradation | 2.285067e-01 | 0.641 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 2.450131e-01 | 0.611 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.450131e-01 | 0.611 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 2.611674e-01 | 0.583 |
| R-HSA-2214320 | Anchoring fibril formation | 2.769770e-01 | 0.558 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.769770e-01 | 0.558 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.769770e-01 | 0.558 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.924493e-01 | 0.534 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 3.224104e-01 | 0.492 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 3.369130e-01 | 0.472 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 3.369130e-01 | 0.472 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 3.511062e-01 | 0.455 |
| R-HSA-1296072 | Voltage gated Potassium channels | 2.461529e-01 | 0.609 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.106204e-01 | 0.676 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.721867e-01 | 0.429 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.377166e-01 | 0.471 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.769770e-01 | 0.558 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 3.224104e-01 | 0.492 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.201201e-01 | 0.495 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.675498e-01 | 0.573 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.435781e-01 | 0.464 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.924493e-01 | 0.534 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.859420e-01 | 0.544 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 3.511062e-01 | 0.455 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.382077e-01 | 0.623 |
| R-HSA-5576893 | Phase 2 - plateau phase | 3.649964e-01 | 0.438 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.461529e-01 | 0.609 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.859420e-01 | 0.544 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.382077e-01 | 0.623 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.259863e-01 | 0.487 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 3.224104e-01 | 0.492 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 1.987761e-01 | 0.702 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.924493e-01 | 0.534 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.779883e-01 | 0.556 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.649964e-01 | 0.438 |
| R-HSA-391251 | Protein folding | 3.786151e-01 | 0.422 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.944064e-01 | 0.711 |
| R-HSA-446107 | Type I hemidesmosome assembly | 2.116404e-01 | 0.674 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.450131e-01 | 0.611 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.450131e-01 | 0.611 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.924493e-01 | 0.534 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 3.075914e-01 | 0.512 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.559901e-01 | 0.592 |
| R-HSA-165159 | MTOR signalling | 2.938865e-01 | 0.532 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 3.511062e-01 | 0.455 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.785901e-01 | 0.422 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.489894e-01 | 0.457 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.489894e-01 | 0.457 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.944064e-01 | 0.711 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 2.285067e-01 | 0.641 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 3.224104e-01 | 0.492 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 3.369130e-01 | 0.472 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.511062e-01 | 0.455 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 3.785901e-01 | 0.422 |
| R-HSA-69541 | Stabilization of p53 | 2.620675e-01 | 0.582 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.649964e-01 | 0.438 |
| R-HSA-8951664 | Neddylation | 2.679410e-01 | 0.572 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.382077e-01 | 0.623 |
| R-HSA-68877 | Mitotic Prometaphase | 3.105705e-01 | 0.508 |
| R-HSA-3371556 | Cellular response to heat stress | 3.342055e-01 | 0.476 |
| R-HSA-71032 | Propionyl-CoA catabolism | 2.611674e-01 | 0.583 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.611674e-01 | 0.583 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 2.769770e-01 | 0.558 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.649964e-01 | 0.438 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.907439e-01 | 0.536 |
| R-HSA-182971 | EGFR downregulation | 1.909819e-01 | 0.719 |
| R-HSA-169893 | Prolonged ERK activation events | 3.511062e-01 | 0.455 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.030990e-01 | 0.518 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 2.285067e-01 | 0.641 |
| R-HSA-2028269 | Signaling by Hippo | 3.785901e-01 | 0.422 |
| R-HSA-390696 | Adrenoceptors | 2.116404e-01 | 0.674 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.924493e-01 | 0.534 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 3.075914e-01 | 0.512 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.369130e-01 | 0.472 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.223626e-01 | 0.653 |
| R-HSA-1566977 | Fibronectin matrix formation | 3.649964e-01 | 0.438 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.333646e-01 | 0.477 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.580346e-01 | 0.446 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.779883e-01 | 0.556 |
| R-HSA-1632852 | Macroautophagy | 2.579790e-01 | 0.588 |
| R-HSA-5576891 | Cardiac conduction | 2.145965e-01 | 0.668 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.611674e-01 | 0.583 |
| R-HSA-8851805 | MET activates RAS signaling | 2.924493e-01 | 0.534 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 3.224104e-01 | 0.492 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 3.224104e-01 | 0.492 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.066077e-01 | 0.685 |
| R-HSA-9766229 | Degradation of CDH1 | 3.489894e-01 | 0.457 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.622102e-01 | 0.581 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.050767e-01 | 0.688 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 3.511062e-01 | 0.455 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.785901e-01 | 0.422 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.785901e-01 | 0.422 |
| R-HSA-109704 | PI3K Cascade | 3.567560e-01 | 0.448 |
| R-HSA-373760 | L1CAM interactions | 3.099842e-01 | 0.509 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.450131e-01 | 0.611 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.779883e-01 | 0.556 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.083924e-01 | 0.511 |
| R-HSA-9675108 | Nervous system development | 3.261517e-01 | 0.487 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.669290e-01 | 0.574 |
| R-HSA-373755 | Semaphorin interactions | 1.995676e-01 | 0.700 |
| R-HSA-69242 | S Phase | 2.907439e-01 | 0.536 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.944064e-01 | 0.711 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.450131e-01 | 0.611 |
| R-HSA-9856872 | Malate-aspartate shuttle | 3.224104e-01 | 0.492 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.779883e-01 | 0.556 |
| R-HSA-8854214 | TBC/RABGAPs | 3.018188e-01 | 0.520 |
| R-HSA-392499 | Metabolism of proteins | 2.253135e-01 | 0.647 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.097356e-01 | 0.509 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.859494e-01 | 0.544 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.824769e-01 | 0.549 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.924493e-01 | 0.534 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 3.369130e-01 | 0.472 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.144715e-01 | 0.669 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 3.511062e-01 | 0.455 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 2.116404e-01 | 0.674 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 2.302762e-01 | 0.638 |
| R-HSA-6807070 | PTEN Regulation | 2.499297e-01 | 0.602 |
| R-HSA-9754706 | Atorvastatin ADME | 3.511062e-01 | 0.455 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.419599e-01 | 0.616 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.382077e-01 | 0.623 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.995676e-01 | 0.700 |
| R-HSA-163685 | Integration of energy metabolism | 2.379814e-01 | 0.623 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.559901e-01 | 0.592 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.786151e-01 | 0.422 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.908344e-01 | 0.536 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.541075e-01 | 0.595 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.669692e-01 | 0.435 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.798466e-01 | 0.420 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.798466e-01 | 0.420 |
| R-HSA-180292 | GAB1 signalosome | 3.918937e-01 | 0.407 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.918937e-01 | 0.407 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.918937e-01 | 0.407 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.918937e-01 | 0.407 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 3.918937e-01 | 0.407 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.918937e-01 | 0.407 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.918937e-01 | 0.407 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.918937e-01 | 0.407 |
| R-HSA-5578775 | Ion homeostasis | 4.025820e-01 | 0.395 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.025820e-01 | 0.395 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.047104e-01 | 0.393 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 4.049132e-01 | 0.393 |
| R-HSA-110320 | Translesion Synthesis by POLH | 4.049132e-01 | 0.393 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 4.049132e-01 | 0.393 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.100734e-01 | 0.387 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.100734e-01 | 0.387 |
| R-HSA-112399 | IRS-mediated signalling | 4.100734e-01 | 0.387 |
| R-HSA-1483166 | Synthesis of PA | 4.100734e-01 | 0.387 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.175184e-01 | 0.379 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 4.176548e-01 | 0.379 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 4.176548e-01 | 0.379 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 4.176548e-01 | 0.379 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 4.176548e-01 | 0.379 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 4.176548e-01 | 0.379 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.189629e-01 | 0.378 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.189629e-01 | 0.378 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.189629e-01 | 0.378 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.246610e-01 | 0.372 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.249159e-01 | 0.372 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.249159e-01 | 0.372 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 4.301243e-01 | 0.366 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 4.301243e-01 | 0.366 |
| R-HSA-2161541 | Abacavir metabolism | 4.301243e-01 | 0.366 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.301243e-01 | 0.366 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.301243e-01 | 0.366 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 4.301243e-01 | 0.366 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.357534e-01 | 0.361 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.359985e-01 | 0.361 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.395623e-01 | 0.357 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 4.423275e-01 | 0.354 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 4.423275e-01 | 0.354 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 4.423275e-01 | 0.354 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 4.423275e-01 | 0.354 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 4.423275e-01 | 0.354 |
| R-HSA-9755088 | Ribavirin ADME | 4.423275e-01 | 0.354 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 4.423275e-01 | 0.354 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.423275e-01 | 0.354 |
| R-HSA-1268020 | Mitochondrial protein import | 4.468089e-01 | 0.350 |
| R-HSA-422475 | Axon guidance | 4.509863e-01 | 0.346 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.540028e-01 | 0.343 |
| R-HSA-8848021 | Signaling by PTK6 | 4.540028e-01 | 0.343 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.540028e-01 | 0.343 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 4.542702e-01 | 0.343 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 4.542702e-01 | 0.343 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 4.542702e-01 | 0.343 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 4.542702e-01 | 0.343 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 4.542702e-01 | 0.343 |
| R-HSA-8964038 | LDL clearance | 4.542702e-01 | 0.343 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 4.542702e-01 | 0.343 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.547171e-01 | 0.342 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.594260e-01 | 0.338 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.611429e-01 | 0.336 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.611429e-01 | 0.336 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.639608e-01 | 0.334 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 4.659579e-01 | 0.332 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 4.659579e-01 | 0.332 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.659579e-01 | 0.332 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 4.659579e-01 | 0.332 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.659579e-01 | 0.332 |
| R-HSA-200425 | Carnitine shuttle | 4.659579e-01 | 0.332 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.682284e-01 | 0.330 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.773959e-01 | 0.321 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.773959e-01 | 0.321 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.773959e-01 | 0.321 |
| R-HSA-429947 | Deadenylation of mRNA | 4.773959e-01 | 0.321 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.773959e-01 | 0.321 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.773959e-01 | 0.321 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.781183e-01 | 0.320 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.784255e-01 | 0.320 |
| R-HSA-166520 | Signaling by NTRKs | 4.827531e-01 | 0.316 |
| R-HSA-9758941 | Gastrulation | 4.873716e-01 | 0.312 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.885896e-01 | 0.311 |
| R-HSA-9620244 | Long-term potentiation | 4.885896e-01 | 0.311 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.885896e-01 | 0.311 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.885896e-01 | 0.311 |
| R-HSA-3000157 | Laminin interactions | 4.885896e-01 | 0.311 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.891473e-01 | 0.311 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.911939e-01 | 0.309 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.960052e-01 | 0.305 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.995443e-01 | 0.301 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.995443e-01 | 0.301 |
| R-HSA-70635 | Urea cycle | 4.995443e-01 | 0.301 |
| R-HSA-2161522 | Abacavir ADME | 4.995443e-01 | 0.301 |
| R-HSA-525793 | Myogenesis | 4.995443e-01 | 0.301 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 4.995443e-01 | 0.301 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.011253e-01 | 0.300 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.028044e-01 | 0.299 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.095441e-01 | 0.293 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.096427e-01 | 0.293 |
| R-HSA-73887 | Death Receptor Signaling | 5.102052e-01 | 0.292 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 5.102650e-01 | 0.292 |
| R-HSA-8949613 | Cristae formation | 5.102650e-01 | 0.292 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 5.102650e-01 | 0.292 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 5.102650e-01 | 0.292 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 5.102650e-01 | 0.292 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.162240e-01 | 0.287 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 5.207566e-01 | 0.283 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 5.207566e-01 | 0.283 |
| R-HSA-77387 | Insulin receptor recycling | 5.207566e-01 | 0.283 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 5.207566e-01 | 0.283 |
| R-HSA-5620971 | Pyroptosis | 5.207566e-01 | 0.283 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.228433e-01 | 0.282 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.231847e-01 | 0.281 |
| R-HSA-162587 | HIV Life Cycle | 5.236834e-01 | 0.281 |
| R-HSA-72086 | mRNA Capping | 5.310241e-01 | 0.275 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 5.310241e-01 | 0.275 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 5.310241e-01 | 0.275 |
| R-HSA-418360 | Platelet calcium homeostasis | 5.310241e-01 | 0.275 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 5.310241e-01 | 0.275 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 5.310241e-01 | 0.275 |
| R-HSA-9006335 | Signaling by Erythropoietin | 5.310241e-01 | 0.275 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.358988e-01 | 0.271 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.387110e-01 | 0.269 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 5.410723e-01 | 0.267 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.410723e-01 | 0.267 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 5.410723e-01 | 0.267 |
| R-HSA-114452 | Activation of BH3-only proteins | 5.410723e-01 | 0.267 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 5.410723e-01 | 0.267 |
| R-HSA-168256 | Immune System | 5.423538e-01 | 0.266 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.489002e-01 | 0.261 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.489002e-01 | 0.261 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.509058e-01 | 0.259 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 5.509058e-01 | 0.259 |
| R-HSA-5694530 | Cargo concentration in the ER | 5.509058e-01 | 0.259 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.509058e-01 | 0.259 |
| R-HSA-4086400 | PCP/CE pathway | 5.550182e-01 | 0.256 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5.605292e-01 | 0.251 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.605292e-01 | 0.251 |
| R-HSA-9659379 | Sensory processing of sound | 5.612664e-01 | 0.251 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.639340e-01 | 0.249 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.639340e-01 | 0.249 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.699469e-01 | 0.244 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.699469e-01 | 0.244 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.699469e-01 | 0.244 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.699469e-01 | 0.244 |
| R-HSA-354192 | Integrin signaling | 5.699469e-01 | 0.244 |
| R-HSA-68882 | Mitotic Anaphase | 5.783002e-01 | 0.238 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.791634e-01 | 0.237 |
| R-HSA-189483 | Heme degradation | 5.791634e-01 | 0.237 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.820322e-01 | 0.235 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.881829e-01 | 0.230 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 5.881829e-01 | 0.230 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.881829e-01 | 0.230 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.881829e-01 | 0.230 |
| R-HSA-5673000 | RAF activation | 5.881829e-01 | 0.230 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.970097e-01 | 0.224 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.970097e-01 | 0.224 |
| R-HSA-187687 | Signalling to ERKs | 5.970097e-01 | 0.224 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.970097e-01 | 0.224 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.970097e-01 | 0.224 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.970097e-01 | 0.224 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.974311e-01 | 0.224 |
| R-HSA-8853659 | RET signaling | 6.056478e-01 | 0.218 |
| R-HSA-3371511 | HSF1 activation | 6.056478e-01 | 0.218 |
| R-HSA-8941326 | RUNX2 regulates bone development | 6.056478e-01 | 0.218 |
| R-HSA-111933 | Calmodulin induced events | 6.056478e-01 | 0.218 |
| R-HSA-111997 | CaM pathway | 6.056478e-01 | 0.218 |
| R-HSA-163560 | Triglyceride catabolism | 6.056478e-01 | 0.218 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 6.056478e-01 | 0.218 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 6.141012e-01 | 0.212 |
| R-HSA-419037 | NCAM1 interactions | 6.141012e-01 | 0.212 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 6.141012e-01 | 0.212 |
| R-HSA-8948216 | Collagen chain trimerization | 6.141012e-01 | 0.212 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.150494e-01 | 0.211 |
| R-HSA-9909396 | Circadian clock | 6.209199e-01 | 0.207 |
| R-HSA-8875878 | MET promotes cell motility | 6.223740e-01 | 0.206 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 6.304699e-01 | 0.200 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 6.304699e-01 | 0.200 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.313169e-01 | 0.200 |
| R-HSA-3371568 | Attenuation phase | 6.383927e-01 | 0.195 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 6.383927e-01 | 0.195 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 6.383927e-01 | 0.195 |
| R-HSA-167169 | HIV Transcription Elongation | 6.383927e-01 | 0.195 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 6.383927e-01 | 0.195 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 6.383927e-01 | 0.195 |
| R-HSA-5260271 | Diseases of Immune System | 6.383927e-01 | 0.195 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.383927e-01 | 0.195 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.431195e-01 | 0.192 |
| R-HSA-69275 | G2/M Transition | 6.473784e-01 | 0.189 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 6.537338e-01 | 0.185 |
| R-HSA-167161 | HIV Transcription Initiation | 6.537338e-01 | 0.185 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 6.537338e-01 | 0.185 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.537338e-01 | 0.185 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 6.537338e-01 | 0.185 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 6.537338e-01 | 0.185 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 6.537338e-01 | 0.185 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 6.537338e-01 | 0.185 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.548281e-01 | 0.184 |
| R-HSA-1474290 | Collagen formation | 6.578263e-01 | 0.182 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.578263e-01 | 0.182 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.585279e-01 | 0.181 |
| R-HSA-9664407 | Parasite infection | 6.602102e-01 | 0.180 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.602102e-01 | 0.180 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.602102e-01 | 0.180 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 6.611592e-01 | 0.180 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6.611592e-01 | 0.180 |
| R-HSA-111996 | Ca-dependent events | 6.611592e-01 | 0.180 |
| R-HSA-5617833 | Cilium Assembly | 6.621720e-01 | 0.179 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.643896e-01 | 0.178 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.671957e-01 | 0.176 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.684259e-01 | 0.175 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.684259e-01 | 0.175 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.729885e-01 | 0.172 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.729885e-01 | 0.172 |
| R-HSA-1296071 | Potassium Channels | 6.729885e-01 | 0.172 |
| R-HSA-190828 | Gap junction trafficking | 6.755371e-01 | 0.170 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.755371e-01 | 0.170 |
| R-HSA-5683826 | Surfactant metabolism | 6.755371e-01 | 0.170 |
| R-HSA-373752 | Netrin-1 signaling | 6.755371e-01 | 0.170 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.755371e-01 | 0.170 |
| R-HSA-69236 | G1 Phase | 6.755371e-01 | 0.170 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.764305e-01 | 0.170 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.765407e-01 | 0.170 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.779202e-01 | 0.169 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.779202e-01 | 0.169 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.793552e-01 | 0.168 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.824963e-01 | 0.166 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.824963e-01 | 0.166 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.824963e-01 | 0.166 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 6.824963e-01 | 0.166 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.824963e-01 | 0.166 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.827913e-01 | 0.166 |
| R-HSA-422356 | Regulation of insulin secretion | 6.827913e-01 | 0.166 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.893066e-01 | 0.162 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.893066e-01 | 0.162 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.893066e-01 | 0.162 |
| R-HSA-75153 | Apoptotic execution phase | 6.893066e-01 | 0.162 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.016761e-01 | 0.154 |
| R-HSA-1483255 | PI Metabolism | 7.016761e-01 | 0.154 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.039919e-01 | 0.152 |
| R-HSA-157858 | Gap junction trafficking and regulation | 7.088758e-01 | 0.149 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.107639e-01 | 0.148 |
| R-HSA-72172 | mRNA Splicing | 7.138428e-01 | 0.146 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 7.151219e-01 | 0.146 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 7.151219e-01 | 0.146 |
| R-HSA-9833110 | RSV-host interactions | 7.152204e-01 | 0.146 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 7.212343e-01 | 0.142 |
| R-HSA-1989781 | PPARA activates gene expression | 7.226154e-01 | 0.141 |
| R-HSA-5663205 | Infectious disease | 7.236493e-01 | 0.140 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 7.272159e-01 | 0.138 |
| R-HSA-6794361 | Neurexins and neuroligins | 7.272159e-01 | 0.138 |
| R-HSA-69239 | Synthesis of DNA | 7.282459e-01 | 0.138 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.297531e-01 | 0.137 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 7.330695e-01 | 0.135 |
| R-HSA-156588 | Glucuronidation | 7.387978e-01 | 0.131 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 7.444036e-01 | 0.128 |
| R-HSA-109581 | Apoptosis | 7.469673e-01 | 0.127 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.488337e-01 | 0.126 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.498894e-01 | 0.125 |
| R-HSA-5654736 | Signaling by FGFR1 | 7.498894e-01 | 0.125 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 7.498894e-01 | 0.125 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 7.498894e-01 | 0.125 |
| R-HSA-75893 | TNF signaling | 7.498894e-01 | 0.125 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.566870e-01 | 0.121 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 7.605113e-01 | 0.119 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.605336e-01 | 0.119 |
| R-HSA-8979227 | Triglyceride metabolism | 7.656523e-01 | 0.116 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.680695e-01 | 0.115 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.680695e-01 | 0.115 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 7.706833e-01 | 0.113 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.756066e-01 | 0.110 |
| R-HSA-1442490 | Collagen degradation | 7.756066e-01 | 0.110 |
| R-HSA-450294 | MAP kinase activation | 7.756066e-01 | 0.110 |
| R-HSA-112043 | PLC beta mediated events | 7.756066e-01 | 0.110 |
| R-HSA-445717 | Aquaporin-mediated transport | 7.756066e-01 | 0.110 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.804245e-01 | 0.108 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.804245e-01 | 0.108 |
| R-HSA-186797 | Signaling by PDGF | 7.804245e-01 | 0.108 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 7.804245e-01 | 0.108 |
| R-HSA-162906 | HIV Infection | 7.814430e-01 | 0.107 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.825251e-01 | 0.107 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 7.851392e-01 | 0.105 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 7.851392e-01 | 0.105 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.851392e-01 | 0.105 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.897530e-01 | 0.103 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 7.986863e-01 | 0.098 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.994800e-01 | 0.097 |
| R-HSA-112040 | G-protein mediated events | 8.030100e-01 | 0.095 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.055483e-01 | 0.094 |
| R-HSA-194138 | Signaling by VEGF | 8.059282e-01 | 0.094 |
| R-HSA-167172 | Transcription of the HIV genome | 8.072411e-01 | 0.093 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 8.072411e-01 | 0.093 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.072411e-01 | 0.093 |
| R-HSA-5218859 | Regulated Necrosis | 8.072411e-01 | 0.093 |
| R-HSA-6798695 | Neutrophil degranulation | 8.121153e-01 | 0.090 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.152554e-01 | 0.089 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 8.154333e-01 | 0.089 |
| R-HSA-448424 | Interleukin-17 signaling | 8.154333e-01 | 0.089 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 8.154333e-01 | 0.089 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 8.154333e-01 | 0.089 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 8.154333e-01 | 0.089 |
| R-HSA-189445 | Metabolism of porphyrins | 8.193983e-01 | 0.087 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 8.232783e-01 | 0.084 |
| R-HSA-74259 | Purine catabolism | 8.232783e-01 | 0.084 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 8.270752e-01 | 0.082 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.270752e-01 | 0.082 |
| R-HSA-4086398 | Ca2+ pathway | 8.270752e-01 | 0.082 |
| R-HSA-9749641 | Aspirin ADME | 8.270752e-01 | 0.082 |
| R-HSA-983712 | Ion channel transport | 8.276911e-01 | 0.082 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 8.307908e-01 | 0.081 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 8.307908e-01 | 0.081 |
| R-HSA-1226099 | Signaling by FGFR in disease | 8.307908e-01 | 0.081 |
| R-HSA-380287 | Centrosome maturation | 8.344268e-01 | 0.079 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 8.344268e-01 | 0.079 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 8.344268e-01 | 0.079 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 8.344268e-01 | 0.079 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 8.448738e-01 | 0.073 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 8.448738e-01 | 0.073 |
| R-HSA-216083 | Integrin cell surface interactions | 8.448738e-01 | 0.073 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.461183e-01 | 0.073 |
| R-HSA-5654738 | Signaling by FGFR2 | 8.514707e-01 | 0.070 |
| R-HSA-9833482 | PKR-mediated signaling | 8.514707e-01 | 0.070 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.592143e-01 | 0.066 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.609104e-01 | 0.065 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.638369e-01 | 0.064 |
| R-HSA-5357801 | Programmed Cell Death | 8.651088e-01 | 0.063 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.655452e-01 | 0.063 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.696295e-01 | 0.061 |
| R-HSA-438064 | Post NMDA receptor activation events | 8.751763e-01 | 0.058 |
| R-HSA-70268 | Pyruvate metabolism | 8.751763e-01 | 0.058 |
| R-HSA-1643685 | Disease | 8.756363e-01 | 0.058 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.778609e-01 | 0.057 |
| R-HSA-9663891 | Selective autophagy | 8.778609e-01 | 0.057 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.806743e-01 | 0.055 |
| R-HSA-202424 | Downstream TCR signaling | 8.830584e-01 | 0.054 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.830584e-01 | 0.054 |
| R-HSA-9609507 | Protein localization | 8.846995e-01 | 0.053 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.866648e-01 | 0.052 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.877510e-01 | 0.052 |
| R-HSA-9748784 | Drug ADME | 8.887159e-01 | 0.051 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.904441e-01 | 0.050 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.928012e-01 | 0.049 |
| R-HSA-9711097 | Cellular response to starvation | 8.942199e-01 | 0.049 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.942199e-01 | 0.049 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.951076e-01 | 0.048 |
| R-HSA-877300 | Interferon gamma signaling | 8.960343e-01 | 0.048 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.973646e-01 | 0.047 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.978198e-01 | 0.047 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.995732e-01 | 0.046 |
| R-HSA-5389840 | Mitochondrial translation elongation | 9.017344e-01 | 0.045 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 9.017344e-01 | 0.045 |
| R-HSA-112316 | Neuronal System | 9.052616e-01 | 0.043 |
| R-HSA-5368286 | Mitochondrial translation initiation | 9.059186e-01 | 0.043 |
| R-HSA-190236 | Signaling by FGFR | 9.059186e-01 | 0.043 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.071614e-01 | 0.042 |
| R-HSA-9614085 | FOXO-mediated transcription | 9.079436e-01 | 0.042 |
| R-HSA-1483257 | Phospholipid metabolism | 9.097979e-01 | 0.041 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.137615e-01 | 0.039 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 9.156181e-01 | 0.038 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.156628e-01 | 0.038 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.171313e-01 | 0.038 |
| R-HSA-111885 | Opioid Signalling | 9.174349e-01 | 0.037 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 9.174349e-01 | 0.037 |
| R-HSA-418346 | Platelet homeostasis | 9.226545e-01 | 0.035 |
| R-HSA-5419276 | Mitochondrial translation termination | 9.275451e-01 | 0.033 |
| R-HSA-202403 | TCR signaling | 9.291057e-01 | 0.032 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.386989e-01 | 0.027 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.391309e-01 | 0.027 |
| R-HSA-1592230 | Mitochondrial biogenesis | 9.417262e-01 | 0.026 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.429384e-01 | 0.026 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.429822e-01 | 0.025 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.488686e-01 | 0.023 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.532081e-01 | 0.021 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.532081e-01 | 0.021 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.532081e-01 | 0.021 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.534658e-01 | 0.021 |
| R-HSA-114608 | Platelet degranulation | 9.541489e-01 | 0.020 |
| R-HSA-8956319 | Nucleotide catabolism | 9.561054e-01 | 0.019 |
| R-HSA-6805567 | Keratinization | 9.564856e-01 | 0.019 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.570523e-01 | 0.019 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.584488e-01 | 0.018 |
| R-HSA-9658195 | Leishmania infection | 9.584488e-01 | 0.018 |
| R-HSA-9843745 | Adipogenesis | 9.588852e-01 | 0.018 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 9.597723e-01 | 0.018 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.606402e-01 | 0.017 |
| R-HSA-109582 | Hemostasis | 9.628718e-01 | 0.016 |
| R-HSA-5368287 | Mitochondrial translation | 9.654695e-01 | 0.015 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.654695e-01 | 0.015 |
| R-HSA-449147 | Signaling by Interleukins | 9.701473e-01 | 0.013 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.709330e-01 | 0.013 |
| R-HSA-72312 | rRNA processing | 9.730079e-01 | 0.012 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.740011e-01 | 0.011 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.740011e-01 | 0.011 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.751123e-01 | 0.011 |
| R-HSA-913531 | Interferon Signaling | 9.756338e-01 | 0.011 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.792878e-01 | 0.009 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.794645e-01 | 0.009 |
| R-HSA-8957322 | Metabolism of steroids | 9.796348e-01 | 0.009 |
| R-HSA-1474244 | Extracellular matrix organization | 9.819137e-01 | 0.008 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.847515e-01 | 0.007 |
| R-HSA-416476 | G alpha (q) signalling events | 9.851770e-01 | 0.006 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.852715e-01 | 0.006 |
| R-HSA-611105 | Respiratory electron transport | 9.862071e-01 | 0.006 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.862580e-01 | 0.006 |
| R-HSA-168255 | Influenza Infection | 9.865056e-01 | 0.006 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.868164e-01 | 0.006 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.884223e-01 | 0.005 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.897520e-01 | 0.004 |
| R-HSA-8953854 | Metabolism of RNA | 9.898768e-01 | 0.004 |
| R-HSA-428157 | Sphingolipid metabolism | 9.916640e-01 | 0.004 |
| R-HSA-168249 | Innate Immune System | 9.917088e-01 | 0.004 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.935919e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.952893e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.958751e-01 | 0.002 |
| R-HSA-15869 | Metabolism of nucleotides | 9.962155e-01 | 0.002 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.964568e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.967473e-01 | 0.001 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.971264e-01 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.989116e-01 | 0.000 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.990108e-01 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 9.991089e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.992227e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.994037e-01 | 0.000 |
| R-HSA-72766 | Translation | 9.994273e-01 | 0.000 |
| R-HSA-9679506 | SARS-CoV Infections | 9.996968e-01 | 0.000 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.998763e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999476e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999837e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.999936e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999992e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.806 | 0.169 | -3 | 0.798 |
COT |
0.806 | 0.174 | 2 | 0.855 |
CDC7 |
0.800 | 0.183 | 1 | 0.237 |
P90RSK |
0.796 | 0.118 | -3 | 0.795 |
CLK3 |
0.796 | 0.091 | 1 | 0.122 |
NDR2 |
0.792 | 0.081 | -3 | 0.877 |
PIM3 |
0.792 | 0.082 | -3 | 0.864 |
CAMK1B |
0.791 | 0.114 | -3 | 0.880 |
BMPR1B |
0.791 | 0.337 | 1 | 0.374 |
DRAK1 |
0.791 | 0.390 | 1 | 0.374 |
RSK4 |
0.790 | 0.160 | -3 | 0.774 |
GRK6 |
0.790 | 0.222 | 1 | 0.241 |
RSK3 |
0.789 | 0.079 | -3 | 0.792 |
NDR1 |
0.789 | 0.083 | -3 | 0.867 |
SKMLCK |
0.789 | 0.162 | -2 | 0.854 |
MAPKAPK2 |
0.789 | 0.086 | -3 | 0.767 |
PKACG |
0.788 | 0.096 | -2 | 0.812 |
PLK1 |
0.788 | 0.226 | -2 | 0.836 |
AURC |
0.788 | 0.138 | -2 | 0.747 |
MOS |
0.786 | 0.076 | 1 | 0.164 |
TGFBR1 |
0.786 | 0.227 | -2 | 0.802 |
LATS2 |
0.786 | 0.064 | -5 | 0.800 |
MSK1 |
0.785 | 0.126 | -3 | 0.764 |
MAPKAPK3 |
0.785 | 0.062 | -3 | 0.811 |
PKN2 |
0.785 | 0.084 | -3 | 0.862 |
PRKD2 |
0.784 | 0.066 | -3 | 0.811 |
TBK1 |
0.784 | -0.102 | 1 | 0.080 |
CAMK2B |
0.784 | 0.114 | 2 | 0.738 |
PKN3 |
0.784 | 0.024 | -3 | 0.849 |
MTOR |
0.784 | -0.065 | 1 | 0.098 |
GCN2 |
0.784 | -0.084 | 2 | 0.798 |
CAMK2G |
0.783 | 0.018 | 2 | 0.792 |
WNK1 |
0.783 | 0.039 | -2 | 0.835 |
NLK |
0.783 | 0.007 | 1 | 0.114 |
DAPK2 |
0.783 | 0.183 | -3 | 0.884 |
P70S6KB |
0.783 | 0.090 | -3 | 0.825 |
CAMK2A |
0.782 | 0.127 | 2 | 0.750 |
RAF1 |
0.781 | -0.009 | 1 | 0.139 |
CAMK4 |
0.781 | 0.070 | -3 | 0.860 |
TGFBR2 |
0.781 | 0.078 | -2 | 0.824 |
PKACB |
0.781 | 0.117 | -2 | 0.768 |
IKKE |
0.781 | -0.113 | 1 | 0.082 |
ALK4 |
0.781 | 0.206 | -2 | 0.830 |
PRPK |
0.780 | -0.066 | -1 | 0.836 |
CLK2 |
0.780 | 0.113 | -3 | 0.786 |
CAMLCK |
0.780 | 0.098 | -2 | 0.877 |
PAK6 |
0.780 | 0.093 | -2 | 0.776 |
GRK5 |
0.780 | 0.107 | -3 | 0.856 |
CAMK2D |
0.780 | 0.032 | -3 | 0.863 |
GRK1 |
0.780 | 0.113 | -2 | 0.729 |
PIM1 |
0.780 | 0.062 | -3 | 0.809 |
ACVR2A |
0.780 | 0.272 | -2 | 0.810 |
MSK2 |
0.780 | 0.063 | -3 | 0.752 |
PRKX |
0.780 | 0.137 | -3 | 0.734 |
MNK2 |
0.779 | 0.085 | -2 | 0.835 |
PAK1 |
0.779 | 0.073 | -2 | 0.816 |
DSTYK |
0.779 | -0.008 | 2 | 0.845 |
CLK4 |
0.779 | 0.082 | -3 | 0.795 |
IKKB |
0.779 | -0.077 | -2 | 0.726 |
ULK2 |
0.779 | -0.092 | 2 | 0.804 |
MST4 |
0.779 | 0.023 | 2 | 0.775 |
NIK |
0.779 | 0.064 | -3 | 0.902 |
ACVR2B |
0.779 | 0.263 | -2 | 0.814 |
PRKD1 |
0.778 | 0.007 | -3 | 0.846 |
ERK5 |
0.778 | -0.038 | 1 | 0.099 |
HUNK |
0.778 | 0.028 | 2 | 0.841 |
AURB |
0.778 | 0.112 | -2 | 0.750 |
LATS1 |
0.778 | 0.112 | -3 | 0.890 |
PDHK4 |
0.778 | -0.124 | 1 | 0.117 |
CK2A2 |
0.777 | 0.213 | 1 | 0.337 |
GRK2 |
0.777 | 0.269 | -2 | 0.681 |
CLK1 |
0.777 | 0.074 | -3 | 0.781 |
MYLK4 |
0.777 | 0.140 | -2 | 0.824 |
AURA |
0.777 | 0.113 | -2 | 0.724 |
AMPKA1 |
0.777 | 0.043 | -3 | 0.886 |
MNK1 |
0.777 | 0.094 | -2 | 0.847 |
RIPK3 |
0.777 | 0.000 | 3 | 0.685 |
NUAK2 |
0.777 | 0.056 | -3 | 0.873 |
ATR |
0.777 | -0.060 | 1 | 0.103 |
JNK2 |
0.776 | -0.002 | 1 | 0.087 |
PKCD |
0.776 | 0.035 | 2 | 0.765 |
BMPR1A |
0.775 | 0.259 | 1 | 0.353 |
TSSK2 |
0.775 | 0.073 | -5 | 0.864 |
PKG2 |
0.775 | 0.098 | -2 | 0.768 |
KIS |
0.775 | -0.036 | 1 | 0.059 |
BMPR2 |
0.775 | -0.053 | -2 | 0.869 |
PAK3 |
0.775 | 0.038 | -2 | 0.819 |
SRPK1 |
0.775 | 0.006 | -3 | 0.760 |
CK2A1 |
0.775 | 0.233 | 1 | 0.362 |
CDKL1 |
0.774 | 0.005 | -3 | 0.806 |
DYRK2 |
0.774 | -0.008 | 1 | 0.073 |
CDK18 |
0.774 | -0.014 | 1 | 0.075 |
GRK7 |
0.774 | 0.112 | 1 | 0.202 |
SGK3 |
0.773 | 0.081 | -3 | 0.790 |
TSSK1 |
0.773 | 0.056 | -3 | 0.907 |
ULK1 |
0.772 | -0.069 | -3 | 0.801 |
MARK4 |
0.772 | -0.003 | 4 | 0.784 |
DLK |
0.772 | 0.088 | 1 | 0.177 |
CDK1 |
0.772 | -0.007 | 1 | 0.127 |
AMPKA2 |
0.772 | 0.034 | -3 | 0.859 |
MELK |
0.772 | 0.040 | -3 | 0.846 |
CDK17 |
0.771 | -0.022 | 1 | 0.089 |
NIM1 |
0.771 | -0.013 | 3 | 0.733 |
PKCG |
0.771 | 0.057 | 2 | 0.730 |
P38G |
0.771 | -0.019 | 1 | 0.089 |
DCAMKL1 |
0.770 | 0.074 | -3 | 0.839 |
CDK8 |
0.770 | -0.055 | 1 | 0.077 |
HIPK4 |
0.770 | -0.030 | 1 | 0.071 |
CDK19 |
0.770 | -0.047 | 1 | 0.071 |
PLK3 |
0.770 | 0.037 | 2 | 0.788 |
CDK14 |
0.769 | 0.010 | 1 | 0.087 |
PKCB |
0.769 | 0.040 | 2 | 0.716 |
WNK3 |
0.769 | -0.092 | 1 | 0.077 |
CDKL5 |
0.769 | -0.017 | -3 | 0.797 |
PAK2 |
0.769 | 0.048 | -2 | 0.808 |
PRKD3 |
0.769 | 0.034 | -3 | 0.776 |
BRSK1 |
0.769 | 0.072 | -3 | 0.832 |
JNK3 |
0.769 | -0.025 | 1 | 0.078 |
CDK7 |
0.768 | -0.040 | 1 | 0.082 |
ICK |
0.768 | -0.004 | -3 | 0.845 |
PDHK1 |
0.768 | -0.196 | 1 | 0.085 |
ALK2 |
0.768 | 0.137 | -2 | 0.815 |
DYRK4 |
0.768 | -0.001 | 1 | 0.071 |
IKKA |
0.768 | -0.042 | -2 | 0.701 |
PKACA |
0.768 | 0.098 | -2 | 0.730 |
NEK6 |
0.768 | -0.086 | -2 | 0.849 |
RIPK1 |
0.768 | -0.049 | 1 | 0.105 |
NEK7 |
0.767 | -0.124 | -3 | 0.824 |
CAMK1G |
0.767 | 0.047 | -3 | 0.789 |
CHAK2 |
0.767 | -0.051 | -1 | 0.844 |
MASTL |
0.767 | -0.081 | -2 | 0.788 |
SRPK2 |
0.767 | 0.006 | -3 | 0.688 |
AKT2 |
0.767 | 0.066 | -3 | 0.717 |
CDK16 |
0.766 | -0.004 | 1 | 0.078 |
PASK |
0.766 | 0.206 | -3 | 0.868 |
PKCH |
0.766 | 0.033 | 2 | 0.729 |
HIPK2 |
0.766 | -0.008 | 1 | 0.057 |
CDK10 |
0.765 | 0.016 | 1 | 0.088 |
DCAMKL2 |
0.765 | 0.053 | -3 | 0.860 |
DAPK1 |
0.765 | 0.201 | -3 | 0.809 |
GRK4 |
0.765 | -0.016 | -2 | 0.785 |
PLK4 |
0.765 | -0.032 | 2 | 0.738 |
CDK3 |
0.765 | -0.016 | 1 | 0.090 |
GRK3 |
0.765 | 0.209 | -2 | 0.634 |
MLK1 |
0.764 | -0.085 | 2 | 0.797 |
CDK13 |
0.764 | -0.053 | 1 | 0.071 |
CDK2 |
0.764 | -0.003 | 1 | 0.151 |
ATM |
0.764 | -0.066 | 1 | 0.094 |
QIK |
0.764 | 0.012 | -3 | 0.863 |
PKCA |
0.764 | 0.022 | 2 | 0.709 |
PHKG1 |
0.763 | -0.026 | -3 | 0.865 |
DNAPK |
0.763 | -0.069 | 1 | 0.047 |
MARK3 |
0.762 | 0.053 | 4 | 0.721 |
BCKDK |
0.762 | -0.139 | -1 | 0.790 |
CHK1 |
0.762 | 0.025 | -3 | 0.873 |
P38B |
0.762 | -0.036 | 1 | 0.074 |
HIPK1 |
0.762 | 0.007 | 1 | 0.071 |
CDK12 |
0.762 | -0.044 | 1 | 0.069 |
TTBK2 |
0.761 | -0.113 | 2 | 0.733 |
CDK5 |
0.761 | -0.029 | 1 | 0.087 |
DYRK1B |
0.761 | 0.000 | 1 | 0.083 |
PIM2 |
0.761 | 0.054 | -3 | 0.774 |
NEK9 |
0.761 | -0.122 | 2 | 0.816 |
PAK5 |
0.761 | 0.058 | -2 | 0.710 |
P38A |
0.761 | -0.035 | 1 | 0.076 |
IRE1 |
0.761 | -0.080 | 1 | 0.066 |
CDK9 |
0.761 | -0.051 | 1 | 0.070 |
FAM20C |
0.761 | -0.013 | 2 | 0.563 |
NUAK1 |
0.761 | -0.006 | -3 | 0.833 |
ANKRD3 |
0.761 | -0.076 | 1 | 0.118 |
BRSK2 |
0.760 | -0.004 | -3 | 0.856 |
PAK4 |
0.760 | 0.061 | -2 | 0.720 |
SMMLCK |
0.760 | 0.110 | -3 | 0.833 |
ERK1 |
0.760 | -0.044 | 1 | 0.065 |
MEK1 |
0.760 | 0.035 | 2 | 0.830 |
QSK |
0.760 | 0.014 | 4 | 0.752 |
ERK2 |
0.760 | -0.041 | 1 | 0.077 |
DAPK3 |
0.759 | 0.147 | -3 | 0.837 |
DYRK3 |
0.759 | 0.020 | 1 | 0.062 |
CAMK1D |
0.759 | 0.068 | -3 | 0.734 |
YSK4 |
0.758 | -0.072 | 1 | 0.115 |
PKCZ |
0.758 | -0.019 | 2 | 0.776 |
AKT1 |
0.758 | 0.059 | -3 | 0.743 |
PKR |
0.758 | -0.048 | 1 | 0.088 |
SNRK |
0.758 | -0.032 | 2 | 0.787 |
SRPK3 |
0.758 | -0.012 | -3 | 0.728 |
MARK1 |
0.757 | 0.049 | 4 | 0.738 |
PHKG2 |
0.757 | 0.000 | -3 | 0.847 |
P70S6K |
0.757 | 0.036 | -3 | 0.727 |
P38D |
0.757 | -0.036 | 1 | 0.036 |
JNK1 |
0.756 | -0.008 | 1 | 0.100 |
MARK2 |
0.756 | 0.022 | 4 | 0.681 |
NEK2 |
0.756 | -0.087 | 2 | 0.802 |
MLK3 |
0.756 | -0.038 | 2 | 0.719 |
MAPKAPK5 |
0.756 | -0.044 | -3 | 0.727 |
SIK |
0.755 | -0.008 | -3 | 0.805 |
DYRK1A |
0.755 | -0.017 | 1 | 0.068 |
MLK2 |
0.755 | -0.133 | 2 | 0.791 |
GSK3B |
0.754 | 0.061 | 4 | 0.547 |
MST3 |
0.753 | 0.058 | 2 | 0.801 |
TLK2 |
0.753 | -0.088 | 1 | 0.088 |
VRK2 |
0.752 | -0.150 | 1 | 0.097 |
PKCT |
0.752 | -0.001 | 2 | 0.730 |
SMG1 |
0.752 | -0.098 | 1 | 0.069 |
MLK4 |
0.752 | -0.029 | 2 | 0.717 |
IRE2 |
0.751 | -0.097 | 2 | 0.787 |
WNK4 |
0.751 | -0.045 | -2 | 0.821 |
MRCKA |
0.751 | 0.083 | -3 | 0.794 |
CHAK1 |
0.751 | -0.109 | 2 | 0.774 |
GSK3A |
0.750 | 0.053 | 4 | 0.556 |
PKCE |
0.750 | 0.058 | 2 | 0.715 |
MEKK3 |
0.750 | -0.026 | 1 | 0.144 |
PKCI |
0.750 | 0.023 | 2 | 0.744 |
HIPK3 |
0.750 | -0.032 | 1 | 0.047 |
SSTK |
0.750 | 0.021 | 4 | 0.747 |
ZAK |
0.748 | -0.070 | 1 | 0.120 |
PKN1 |
0.747 | 0.012 | -3 | 0.752 |
SGK1 |
0.746 | 0.062 | -3 | 0.631 |
PERK |
0.746 | -0.103 | -2 | 0.840 |
BRAF |
0.746 | -0.030 | -4 | 0.785 |
IRAK4 |
0.746 | -0.076 | 1 | 0.051 |
AKT3 |
0.745 | 0.054 | -3 | 0.649 |
MRCKB |
0.745 | 0.064 | -3 | 0.774 |
MEK5 |
0.744 | -0.097 | 2 | 0.818 |
GAK |
0.744 | 0.007 | 1 | 0.126 |
ROCK2 |
0.744 | 0.081 | -3 | 0.824 |
TLK1 |
0.744 | -0.103 | -2 | 0.808 |
PLK2 |
0.743 | 0.035 | -3 | 0.802 |
CAMK1A |
0.743 | 0.040 | -3 | 0.691 |
HRI |
0.742 | -0.148 | -2 | 0.855 |
GCK |
0.742 | 0.070 | 1 | 0.174 |
CHK2 |
0.742 | 0.042 | -3 | 0.670 |
CK1E |
0.742 | 0.010 | -3 | 0.524 |
PRP4 |
0.742 | -0.033 | -3 | 0.757 |
NEK5 |
0.741 | -0.111 | 1 | 0.080 |
CDK4 |
0.741 | -0.039 | 1 | 0.062 |
TAO3 |
0.741 | -0.028 | 1 | 0.122 |
NEK11 |
0.741 | -0.042 | 1 | 0.137 |
TTBK1 |
0.740 | -0.116 | 2 | 0.669 |
CDK6 |
0.740 | -0.044 | 1 | 0.063 |
DMPK1 |
0.740 | 0.103 | -3 | 0.802 |
HPK1 |
0.739 | 0.053 | 1 | 0.166 |
MEKK1 |
0.739 | -0.160 | 1 | 0.082 |
MEKK2 |
0.738 | -0.117 | 2 | 0.799 |
PDHK3_TYR |
0.738 | 0.194 | 4 | 0.865 |
NEK8 |
0.736 | -0.083 | 2 | 0.827 |
MAK |
0.736 | 0.004 | -2 | 0.694 |
CAMKK1 |
0.736 | -0.071 | -2 | 0.769 |
BUB1 |
0.735 | 0.040 | -5 | 0.809 |
MOK |
0.735 | 0.003 | 1 | 0.063 |
CK1A2 |
0.734 | 0.016 | -3 | 0.470 |
CAMKK2 |
0.734 | -0.055 | -2 | 0.767 |
PDK1 |
0.734 | -0.080 | 1 | 0.083 |
PKG1 |
0.734 | 0.036 | -2 | 0.693 |
TAO2 |
0.734 | -0.067 | 2 | 0.820 |
MPSK1 |
0.734 | -0.094 | 1 | 0.055 |
MAP3K15 |
0.733 | -0.069 | 1 | 0.093 |
ROCK1 |
0.732 | 0.063 | -3 | 0.791 |
SBK |
0.732 | 0.021 | -3 | 0.601 |
PINK1 |
0.732 | -0.179 | 1 | 0.076 |
MEKK6 |
0.732 | -0.067 | 1 | 0.092 |
STK33 |
0.732 | -0.061 | 2 | 0.657 |
LKB1 |
0.732 | -0.079 | -3 | 0.841 |
LOK |
0.731 | -0.046 | -2 | 0.779 |
EEF2K |
0.731 | -0.049 | 3 | 0.771 |
MST2 |
0.730 | -0.055 | 1 | 0.138 |
ERK7 |
0.730 | -0.028 | 2 | 0.552 |
IRAK1 |
0.730 | -0.144 | -1 | 0.767 |
PBK |
0.730 | -0.046 | 1 | 0.062 |
VRK1 |
0.730 | -0.062 | 2 | 0.875 |
NEK4 |
0.730 | -0.117 | 1 | 0.071 |
BMPR2_TYR |
0.729 | 0.191 | -1 | 0.862 |
PDHK4_TYR |
0.729 | 0.113 | 2 | 0.851 |
CK1G1 |
0.728 | -0.068 | -3 | 0.522 |
LRRK2 |
0.728 | -0.069 | 2 | 0.851 |
CRIK |
0.728 | 0.040 | -3 | 0.730 |
KHS2 |
0.728 | 0.013 | 1 | 0.130 |
MINK |
0.728 | -0.076 | 1 | 0.106 |
CK1D |
0.728 | -0.012 | -3 | 0.471 |
NEK1 |
0.727 | -0.098 | 1 | 0.070 |
TAK1 |
0.727 | -0.070 | 1 | 0.124 |
TNIK |
0.727 | -0.064 | 3 | 0.800 |
HGK |
0.727 | -0.095 | 3 | 0.788 |
MST1 |
0.726 | -0.066 | 1 | 0.116 |
KHS1 |
0.726 | -0.038 | 1 | 0.097 |
HASPIN |
0.726 | 0.042 | -1 | 0.814 |
TESK1_TYR |
0.726 | 0.024 | 3 | 0.854 |
RIPK2 |
0.726 | -0.131 | 1 | 0.094 |
MAP2K6_TYR |
0.725 | 0.108 | -1 | 0.857 |
SLK |
0.723 | -0.063 | -2 | 0.704 |
YSK1 |
0.722 | -0.080 | 2 | 0.777 |
MAP2K7_TYR |
0.722 | -0.071 | 2 | 0.858 |
MAP2K4_TYR |
0.722 | -0.003 | -1 | 0.850 |
MEK2 |
0.721 | -0.109 | 2 | 0.814 |
LIMK2_TYR |
0.720 | -0.016 | -3 | 0.908 |
PINK1_TYR |
0.720 | -0.049 | 1 | 0.123 |
TXK |
0.720 | 0.239 | 1 | 0.296 |
PDHK1_TYR |
0.719 | 0.042 | -1 | 0.863 |
BIKE |
0.719 | -0.046 | 1 | 0.073 |
EPHA6 |
0.718 | 0.053 | -1 | 0.833 |
PKMYT1_TYR |
0.718 | -0.064 | 3 | 0.816 |
EPHB4 |
0.714 | 0.031 | -1 | 0.807 |
YANK3 |
0.714 | -0.020 | 2 | 0.430 |
RET |
0.712 | -0.149 | 1 | 0.073 |
DDR1 |
0.712 | -0.061 | 4 | 0.781 |
TTK |
0.712 | -0.031 | -2 | 0.835 |
AAK1 |
0.712 | -0.032 | 1 | 0.045 |
NEK3 |
0.711 | -0.149 | 1 | 0.038 |
LIMK1_TYR |
0.711 | -0.093 | 2 | 0.848 |
ASK1 |
0.710 | -0.101 | 1 | 0.090 |
PTK2B |
0.710 | 0.183 | -1 | 0.741 |
SRMS |
0.710 | 0.095 | 1 | 0.218 |
EPHB1 |
0.709 | 0.063 | 1 | 0.198 |
EPHA4 |
0.709 | 0.035 | 2 | 0.777 |
OSR1 |
0.709 | -0.069 | 2 | 0.770 |
ITK |
0.708 | 0.100 | -1 | 0.770 |
INSRR |
0.707 | 0.024 | 3 | 0.684 |
TYRO3 |
0.707 | -0.054 | 3 | 0.720 |
YES1 |
0.706 | -0.028 | -1 | 0.809 |
MERTK |
0.705 | 0.056 | 3 | 0.728 |
MST1R |
0.705 | -0.161 | 3 | 0.754 |
EPHB2 |
0.705 | 0.027 | -1 | 0.786 |
NEK10_TYR |
0.705 | -0.136 | 1 | 0.046 |
MYO3B |
0.705 | -0.083 | 2 | 0.793 |
JAK3 |
0.704 | -0.112 | 1 | 0.091 |
FGFR2 |
0.704 | -0.098 | 3 | 0.758 |
FER |
0.704 | -0.021 | 1 | 0.173 |
FGR |
0.704 | -0.036 | 1 | 0.158 |
TAO1 |
0.704 | -0.102 | 1 | 0.066 |
PTK2 |
0.703 | 0.185 | -1 | 0.780 |
TNK2 |
0.703 | -0.059 | 3 | 0.707 |
TYK2 |
0.703 | -0.256 | 1 | 0.056 |
ROS1 |
0.702 | -0.107 | 3 | 0.689 |
EPHB3 |
0.702 | -0.019 | -1 | 0.789 |
CK1A |
0.702 | 0.038 | -3 | 0.379 |
BMX |
0.702 | 0.070 | -1 | 0.697 |
MYO3A |
0.701 | -0.099 | 1 | 0.085 |
AXL |
0.701 | -0.029 | 3 | 0.720 |
TNK1 |
0.701 | -0.073 | 3 | 0.707 |
CSF1R |
0.701 | -0.130 | 3 | 0.713 |
PDGFRB |
0.700 | -0.105 | 3 | 0.731 |
DDR2 |
0.700 | -0.021 | 3 | 0.676 |
ABL2 |
0.699 | -0.075 | -1 | 0.768 |
JAK2 |
0.699 | -0.236 | 1 | 0.056 |
ALPHAK3 |
0.699 | -0.096 | -1 | 0.739 |
EPHA7 |
0.699 | 0.021 | 2 | 0.790 |
ABL1 |
0.698 | -0.086 | -1 | 0.758 |
KDR |
0.698 | -0.095 | 3 | 0.685 |
STLK3 |
0.697 | -0.126 | 1 | 0.102 |
NTRK1 |
0.696 | -0.048 | -1 | 0.781 |
TEC |
0.696 | 0.027 | -1 | 0.696 |
FYN |
0.696 | 0.015 | -1 | 0.786 |
KIT |
0.695 | -0.110 | 3 | 0.724 |
FGFR1 |
0.695 | -0.155 | 3 | 0.709 |
EPHA3 |
0.695 | -0.018 | 2 | 0.769 |
FLT1 |
0.695 | -0.074 | -1 | 0.798 |
HCK |
0.695 | -0.088 | -1 | 0.796 |
FGFR3 |
0.694 | -0.090 | 3 | 0.727 |
WEE1_TYR |
0.694 | -0.056 | -1 | 0.733 |
EGFR |
0.694 | -0.053 | 1 | 0.122 |
TEK |
0.694 | -0.108 | 3 | 0.664 |
SYK |
0.694 | 0.089 | -1 | 0.752 |
EPHA5 |
0.694 | 0.011 | 2 | 0.778 |
EPHA1 |
0.692 | -0.060 | 3 | 0.704 |
TNNI3K_TYR |
0.692 | -0.143 | 1 | 0.042 |
ERBB2 |
0.692 | -0.095 | 1 | 0.125 |
LTK |
0.691 | -0.082 | 3 | 0.680 |
MET |
0.691 | -0.074 | 3 | 0.730 |
JAK1 |
0.691 | -0.162 | 1 | 0.058 |
FLT3 |
0.691 | -0.175 | 3 | 0.710 |
FLT4 |
0.690 | -0.119 | 3 | 0.696 |
LCK |
0.690 | -0.087 | -1 | 0.801 |
EPHA8 |
0.690 | 0.002 | -1 | 0.779 |
PDGFRA |
0.690 | -0.190 | 3 | 0.721 |
ALK |
0.690 | -0.066 | 3 | 0.643 |
BLK |
0.689 | -0.076 | -1 | 0.806 |
INSR |
0.689 | -0.063 | 3 | 0.660 |
FRK |
0.689 | -0.073 | -1 | 0.797 |
BTK |
0.689 | -0.100 | -1 | 0.729 |
NTRK2 |
0.688 | -0.100 | 3 | 0.691 |
NTRK3 |
0.688 | -0.053 | -1 | 0.734 |
MUSK |
0.686 | -0.074 | 1 | 0.105 |
EPHA2 |
0.686 | 0.019 | -1 | 0.746 |
PTK6 |
0.685 | -0.154 | -1 | 0.689 |
SRC |
0.684 | -0.038 | -1 | 0.772 |
ERBB4 |
0.683 | -0.004 | 1 | 0.183 |
CSK |
0.681 | -0.085 | 2 | 0.796 |
MATK |
0.680 | -0.068 | -1 | 0.702 |
YANK2 |
0.679 | -0.038 | 2 | 0.434 |
IGF1R |
0.678 | -0.028 | 3 | 0.607 |
FGFR4 |
0.678 | -0.106 | -1 | 0.727 |
LYN |
0.675 | -0.112 | 3 | 0.639 |
FES |
0.673 | 0.064 | -1 | 0.669 |
CK1G3 |
0.670 | -0.057 | -3 | 0.331 |
ZAP70 |
0.664 | -0.040 | -1 | 0.691 |
CK1G2 |
0.659 | -0.024 | -3 | 0.434 |