Motif 422 (n=152)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S801 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A6NKD9 | CCDC85C | S209 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| A6NKT7 | RGPD3 | S1586 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H7C1W4 | None | S54 | ochoa | Uncharacterized protein | None |
| O14646 | CHD1 | S1539 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14715 | RGPD8 | S1585 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14777 | NDC80 | S69 | ochoa|psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15439 | ABCC4 | S664 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O15550 | KDM6A | S817 | ochoa | Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}. |
| O43524 | FOXO3 | S428 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O43822 | CFAP410 | S165 | ochoa | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}. |
| O95208 | EPN2 | S419 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95210 | STBD1 | S57 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95639 | CPSF4 | S230 | ochoa | Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}. |
| P07949 | RET | S689 | ochoa | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P09769 | FGR | S57 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0DPH7 | TUBA3C | T51 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T51 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10636 | MAPT | S515 | ochoa|psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10636 | MAPT | S729 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S1798 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P13796 | LCP1 | S110 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P13804 | ETFA | S185 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P15884 | TCF4 | S507 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P16144 | ITGB4 | S1208 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16234 | PDGFRA | S1041 | ochoa | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| P18850 | ATF6 | S97 | ochoa | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] | [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}. |
| P23677 | ITPKA | S123 | ochoa | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}. |
| P24394 | IL4R | S667 | ochoa | Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] | Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:17030238, ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}. |
| P28715 | ERCC5 | S310 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P35269 | GTF2F1 | S217 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P37275 | ZEB1 | S574 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P48444 | ARCN1 | S188 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P48634 | PRRC2A | S159 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49790 | NUP153 | S188 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49790 | NUP153 | S1456 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1449 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S1832 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2561 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52594 | AGFG1 | S146 | ochoa | Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) | Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}. |
| P52594 | AGFG1 | S149 | ochoa | Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) | Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}. |
| P55196 | AFDN | S239 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P57078 | RIPK4 | S423 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P60709 | ACTB | S52 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S54 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S52 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S53 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S54 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S54 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68363 | TUBA1B | T51 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P78310 | CXADR | S300 | ochoa | Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}. |
| P82094 | TMF1 | S250 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01082 | SPTBN1 | S2041 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q08378 | GOLGA3 | S278 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q08AD1 | CAMSAP2 | S1339 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S5863 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12778 | FOXO1 | S318 | ochoa | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q13085 | ACACA | S1203 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13131 | PRKAA1 | S516 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13409 | DYNC1I2 | S104 | ochoa | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}. |
| Q13416 | ORC2 | S138 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13835 | PKP1 | Y184 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14126 | DSG2 | S886 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14687 | GSE1 | S83 | ochoa | Genetic suppressor element 1 | None |
| Q14699 | RFTN1 | S167 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14980 | NUMA1 | S1833 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | Y1836 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15149 | PLEC | S4385 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15722 | LTB4R | S313 | ochoa|psp | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Q15746 | MYLK | S1772 | ochoa|psp | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16625 | OCLN | S340 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q2M1P5 | KIF7 | S455 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q4VCS5 | AMOT | S312 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q53GG5 | PDLIM3 | S151 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5PRF9 | SAMD4B | S274 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5T1R4 | HIVEP3 | S804 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5VT52 | RPRD2 | Y592 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VZ89 | DENND4C | S1060 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5W0B1 | OBI1 | S570 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q69YH5 | CDCA2 | S198 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6IQ23 | PLEKHA7 | S117 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6PEY2 | TUBA3E | T51 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6Y7W6 | GIGYF2 | S19 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6ZVM7 | TOM1L2 | S423 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q71RC2 | LARP4 | S381 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q71U36 | TUBA1A | T51 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q765P7 | MTSS2 | S321 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7Z2W4 | ZC3HAV1 | S386 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3J3 | RGPD4 | S1586 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86XA9 | HEATR5A | S829 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86YW5 | TREML1 | S201 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IUD2 | ERC1 | S994 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8N3U4 | STAG2 | S1064 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
| Q8NCG7 | DAGLB | S178 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
| Q8ND83 | SLAIN1 | S246 | ochoa | SLAIN motif-containing protein 1 | Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. {ECO:0000269|PubMed:21646404}. |
| Q8NDF8 | TENT4B | S48 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8NDI1 | EHBP1 | S659 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NHV4 | NEDD1 | S396 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8NI27 | THOC2 | S1211 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TB45 | DEPTOR | S282 | ochoa|psp | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8WUM0 | NUP133 | S492 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WWM7 | ATXN2L | S597 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WXE9 | STON2 | S295 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q8WYP5 | AHCTF1 | S1153 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92793 | CREBBP | S976 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92993 | KAT5 | S202 | ochoa | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}. |
| Q93052 | LPP | S144 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q93075 | TATDN2 | S111 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96RT1 | ERBIN | S1078 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99081 | TCF12 | S72 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99081 | TCF12 | S163 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99081 | TCF12 | S304 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99666 | RGPD5 | S1585 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99683 | MAP3K5 | S1227 | ochoa | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q9BPU6 | DPYSL5 | S531 | ochoa | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | Involved in the negative regulation of dendrite outgrowth. {ECO:0000269|PubMed:33894126}. |
| Q9BPU6 | DPYSL5 | S534 | ochoa | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | Involved in the negative regulation of dendrite outgrowth. {ECO:0000269|PubMed:33894126}. |
| Q9BQE3 | TUBA1C | T51 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BR39 | JPH2 | S164 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BRR8 | GPATCH1 | S199 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BVJ6 | UTP14A | S77 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW04 | SARG | S312 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BYT3 | STK33 | S46 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9BYW2 | SETD2 | S1239 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZ67 | FRMD8 | S20 | ochoa | FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. |
| Q9BZ67 | FRMD8 | S23 | ochoa | FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. |
| Q9BZ68 | FRMD8P1 | S20 | ochoa | Putative FERM domain-containing protein FRMD8P1 (FERM domain-containing 8 pseudogene 1) | None |
| Q9BZ68 | FRMD8P1 | S23 | ochoa | Putative FERM domain-containing protein FRMD8P1 (FERM domain-containing 8 pseudogene 1) | None |
| Q9C0D5 | TANC1 | S303 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H4L5 | OSBPL3 | S326 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H6T3 | RPAP3 | S506 | ochoa | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H7P6 | MVB12B | S200 | ochoa | Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. |
| Q9HCM3 | KIAA1549 | S1913 | ochoa | UPF0606 protein KIAA1549 | May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}. |
| Q9NPI6 | DCP1A | S179 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NQE9 | HINT3 | S27 | ochoa | Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). {ECO:0000269|PubMed:17870088}. |
| Q9NTI5 | PDS5B | S1139 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NX63 | CHCHD3 | Y49 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9NZB2 | FAM120A | S1044 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P265 | DIP2B | S258 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UD71 | PPP1R1B | S45 | ochoa | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) | Inhibitor of protein-phosphatase 1. |
| Q9UDT6 | CLIP2 | S30 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UGV2 | NDRG3 | S334 | ochoa | Protein NDRG3 (N-myc downstream-regulated gene 3 protein) | None |
| Q9ULT8 | HECTD1 | S251 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UPN9 | TRIM33 | S855 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9Y263 | PLAA | S484 | ochoa | Phospholipase A-2-activating protein (PLA2P) (PLAP) | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). {ECO:0000250|UniProtKB:P27612, ECO:0000269|PubMed:18291623, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}. |
| Q9Y3L3 | SH3BP1 | S168 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y5S2 | CDC42BPB | S1643 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y6D6 | ARFGEF1 | S396 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| R4GMW8 | BIVM-ERCC5 | S764 | ochoa | DNA excision repair protein ERCC-5 | None |
| P78371 | CCT2 | S143 | Sugiyama | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9H3Q1 | CDC42EP4 | S311 | Sugiyama | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| P13797 | PLS3 | S113 | Sugiyama | Plastin-3 (T-fimbrin) (T-plastin) | Actin-bundling protein. |
| Q96PH1 | NOX5 | S547 | SIGNOR | NADPH oxidase 5 (EC 1.6.3.-) | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516). {ECO:0000269|PubMed:12686516}.; FUNCTION: [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:11483596, PubMed:14982937, PubMed:17275676, PubMed:17587483, PubMed:21642394, PubMed:22387196, PubMed:22427510, PubMed:24505490, PubMed:36653838). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin (PubMed:17275676). Regulates redox-dependent processes in lymphocytes and spermatozoa (PubMed:11483596). {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:14982937, ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:17587483, ECO:0000269|PubMed:21642394, ECO:0000269|PubMed:22387196, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:24505490, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:21319793, ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v5]: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner (PubMed:17275676, PubMed:36653838). May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). However another study showed an absence of oxidase activity (PubMed:22427510). Subject to rapid degradation (PubMed:36653838). {ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.920894e-09 | 8.534 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.600717e-09 | 8.252 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.641075e-09 | 8.785 |
| R-HSA-68877 | Mitotic Prometaphase | 5.464676e-09 | 8.262 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.083257e-08 | 7.511 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.443810e-08 | 7.264 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.322027e-08 | 7.274 |
| R-HSA-190828 | Gap junction trafficking | 7.506067e-08 | 7.125 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.238642e-07 | 6.907 |
| R-HSA-437239 | Recycling pathway of L1 | 1.146157e-07 | 6.941 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.603911e-07 | 6.795 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.499618e-07 | 6.824 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.601729e-07 | 6.585 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.132434e-07 | 6.212 |
| R-HSA-9646399 | Aggrephagy | 6.192449e-07 | 6.208 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.705127e-07 | 6.113 |
| R-HSA-68882 | Mitotic Anaphase | 9.798891e-07 | 6.009 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.026389e-06 | 5.989 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.711161e-06 | 5.767 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.035181e-06 | 5.691 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.475844e-06 | 5.606 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.339813e-06 | 5.476 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.722782e-06 | 5.429 |
| R-HSA-68886 | M Phase | 3.737797e-06 | 5.427 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.210275e-06 | 5.376 |
| R-HSA-190861 | Gap junction assembly | 4.434670e-06 | 5.353 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.979118e-06 | 5.156 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.979118e-06 | 5.156 |
| R-HSA-373760 | L1CAM interactions | 8.115173e-06 | 5.091 |
| R-HSA-391251 | Protein folding | 1.077484e-05 | 4.968 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.144688e-05 | 4.941 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.209617e-05 | 4.917 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.403968e-05 | 4.853 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.795366e-05 | 4.746 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.227866e-05 | 4.652 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 2.302253e-05 | 4.638 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.453485e-05 | 4.610 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.958944e-05 | 4.529 |
| R-HSA-9833482 | PKR-mediated signaling | 3.543767e-05 | 4.451 |
| R-HSA-1500931 | Cell-Cell communication | 4.092967e-05 | 4.388 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.700057e-05 | 4.328 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.151784e-05 | 4.288 |
| R-HSA-446728 | Cell junction organization | 5.592229e-05 | 4.252 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.776600e-05 | 4.238 |
| R-HSA-9663891 | Selective autophagy | 6.498924e-05 | 4.187 |
| R-HSA-9609690 | HCMV Early Events | 7.384681e-05 | 4.132 |
| R-HSA-983189 | Kinesins | 7.387882e-05 | 4.131 |
| R-HSA-9612973 | Autophagy | 7.697689e-05 | 4.114 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.647824e-05 | 4.063 |
| R-HSA-9609646 | HCMV Infection | 1.035974e-04 | 3.985 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.188192e-04 | 3.925 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.436128e-04 | 3.843 |
| R-HSA-1640170 | Cell Cycle | 1.501413e-04 | 3.823 |
| R-HSA-418990 | Adherens junctions interactions | 1.677025e-04 | 3.775 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 2.043980e-04 | 3.690 |
| R-HSA-1632852 | Macroautophagy | 2.227422e-04 | 3.652 |
| R-HSA-75153 | Apoptotic execution phase | 2.394357e-04 | 3.621 |
| R-HSA-69275 | G2/M Transition | 2.588395e-04 | 3.587 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.777285e-04 | 3.556 |
| R-HSA-5620924 | Intraflagellar transport | 2.826034e-04 | 3.549 |
| R-HSA-5617833 | Cilium Assembly | 2.977462e-04 | 3.526 |
| R-HSA-162582 | Signal Transduction | 3.579503e-04 | 3.446 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.650974e-04 | 3.438 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 4.121816e-04 | 3.385 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.166323e-04 | 3.380 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.445641e-04 | 3.352 |
| R-HSA-199991 | Membrane Trafficking | 4.527189e-04 | 3.344 |
| R-HSA-421270 | Cell-cell junction organization | 4.638814e-04 | 3.334 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.221102e-04 | 3.282 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 6.062834e-04 | 3.217 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.189388e-04 | 3.143 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.959819e-04 | 3.099 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.959819e-04 | 3.099 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.821774e-04 | 3.008 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 9.904950e-04 | 3.004 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.286075e-03 | 2.891 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.390796e-03 | 2.857 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.444087e-03 | 2.840 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.286075e-03 | 2.891 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.710745e-03 | 2.767 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.307777e-03 | 2.637 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.417580e-03 | 2.617 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.587876e-03 | 2.587 |
| R-HSA-913531 | Interferon Signaling | 2.777177e-03 | 2.556 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.778217e-03 | 2.556 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.778217e-03 | 2.556 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 3.053060e-03 | 2.515 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.182652e-03 | 2.497 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.415166e-03 | 2.467 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.717657e-03 | 2.430 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.670379e-03 | 2.331 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.361895e-03 | 2.360 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.696710e-03 | 2.328 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 4.708066e-03 | 2.327 |
| R-HSA-8939211 | ESR-mediated signaling | 4.763094e-03 | 2.322 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.087998e-03 | 2.293 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.451939e-03 | 2.263 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.571884e-03 | 2.254 |
| R-HSA-446107 | Type I hemidesmosome assembly | 5.659459e-03 | 2.247 |
| R-HSA-196025 | Formation of annular gap junctions | 5.659459e-03 | 2.247 |
| R-HSA-190873 | Gap junction degradation | 6.691159e-03 | 2.174 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 5.965738e-03 | 2.224 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 6.429835e-03 | 2.192 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 6.429835e-03 | 2.192 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.623675e-03 | 2.179 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.730709e-03 | 2.242 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 6.691159e-03 | 2.174 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 6.691159e-03 | 2.174 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 6.018833e-03 | 2.220 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 7.421113e-03 | 2.130 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 7.421113e-03 | 2.130 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 7.801484e-03 | 2.108 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 7.801484e-03 | 2.108 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 7.948731e-03 | 2.100 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 7.948731e-03 | 2.100 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 1.001011e-02 | 2.000 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 1.001011e-02 | 2.000 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 1.001011e-02 | 2.000 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 1.001011e-02 | 2.000 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 1.001011e-02 | 2.000 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 1.001011e-02 | 2.000 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 9.068920e-03 | 2.042 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 9.442929e-03 | 2.025 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 8.988774e-03 | 2.046 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.025140e-02 | 1.989 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.027689e-02 | 1.988 |
| R-HSA-180746 | Nuclear import of Rev protein | 8.497938e-03 | 2.071 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 8.497938e-03 | 2.071 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.091419e-02 | 1.962 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.200356e-02 | 1.921 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.225613e-02 | 1.912 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.225613e-02 | 1.912 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.296100e-02 | 1.887 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.497173e-02 | 1.825 |
| R-HSA-196780 | Biotin transport and metabolism | 1.602344e-02 | 1.795 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.602344e-02 | 1.795 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.682834e-02 | 1.774 |
| R-HSA-2262752 | Cellular responses to stress | 1.744466e-02 | 1.758 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.767094e-02 | 1.753 |
| R-HSA-1266738 | Developmental Biology | 2.253321e-02 | 1.647 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.287647e-02 | 1.641 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.315664e-02 | 1.635 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.321416e-02 | 1.634 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.349723e-02 | 1.629 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.355226e-02 | 1.628 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.410774e-02 | 1.618 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.421946e-02 | 1.616 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 2.973255e-02 | 1.527 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.249740e-02 | 1.488 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.071731e-02 | 1.513 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 2.973255e-02 | 1.527 |
| R-HSA-191859 | snRNP Assembly | 3.073887e-02 | 1.512 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.073887e-02 | 1.512 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.847307e-02 | 1.546 |
| R-HSA-422475 | Axon guidance | 2.871958e-02 | 1.542 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.737486e-02 | 1.563 |
| R-HSA-1474244 | Extracellular matrix organization | 2.645302e-02 | 1.578 |
| R-HSA-162587 | HIV Life Cycle | 3.278193e-02 | 1.484 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.498056e-02 | 1.456 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.554650e-02 | 1.449 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.554650e-02 | 1.449 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.609046e-02 | 1.443 |
| R-HSA-109581 | Apoptosis | 3.629588e-02 | 1.440 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.740407e-02 | 1.427 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.939154e-02 | 1.405 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.944684e-02 | 1.404 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.944684e-02 | 1.404 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.944684e-02 | 1.404 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.944684e-02 | 1.404 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.944684e-02 | 1.404 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.944684e-02 | 1.404 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.944684e-02 | 1.404 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.944684e-02 | 1.404 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.944684e-02 | 1.404 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.944684e-02 | 1.404 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.944684e-02 | 1.404 |
| R-HSA-9839394 | TGFBR3 expression | 3.945833e-02 | 1.404 |
| R-HSA-3214842 | HDMs demethylate histones | 3.945833e-02 | 1.404 |
| R-HSA-9830364 | Formation of the nephric duct | 3.945833e-02 | 1.404 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.086436e-02 | 1.389 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.177449e-02 | 1.379 |
| R-HSA-525793 | Myogenesis | 4.177449e-02 | 1.379 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.206757e-02 | 1.376 |
| R-HSA-9675108 | Nervous system development | 4.221629e-02 | 1.375 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.445000e-02 | 1.352 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.658673e-02 | 1.332 |
| R-HSA-68875 | Mitotic Prophase | 4.731085e-02 | 1.325 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.768638e-02 | 1.322 |
| R-HSA-3371556 | Cellular response to heat stress | 4.837427e-02 | 1.315 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.901724e-02 | 1.310 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.914598e-02 | 1.309 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.062730e-02 | 1.296 |
| R-HSA-168255 | Influenza Infection | 5.081599e-02 | 1.294 |
| R-HSA-380287 | Centrosome maturation | 5.213020e-02 | 1.283 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.213020e-02 | 1.283 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 5.858637e-02 | 1.232 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 5.858637e-02 | 1.232 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 5.858637e-02 | 1.232 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 6.801352e-02 | 1.167 |
| R-HSA-390522 | Striated Muscle Contraction | 6.199876e-02 | 1.208 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 7.312258e-02 | 1.136 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 7.734685e-02 | 1.112 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.660426e-02 | 1.176 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 6.801352e-02 | 1.167 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 7.734685e-02 | 1.112 |
| R-HSA-9659379 | Sensory processing of sound | 5.835492e-02 | 1.234 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.878022e-02 | 1.104 |
| R-HSA-4839726 | Chromatin organization | 5.567162e-02 | 1.254 |
| R-HSA-5357801 | Programmed Cell Death | 7.815520e-02 | 1.107 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.899182e-02 | 1.102 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.918027e-02 | 1.101 |
| R-HSA-397014 | Muscle contraction | 8.631985e-02 | 1.064 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 8.658727e-02 | 1.063 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 8.658727e-02 | 1.063 |
| R-HSA-391906 | Leukotriene receptors | 8.658727e-02 | 1.063 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.752162e-02 | 1.058 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 8.784081e-02 | 1.056 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.784081e-02 | 1.056 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.784081e-02 | 1.056 |
| R-HSA-9758941 | Gastrulation | 8.921308e-02 | 1.050 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.069433e-02 | 1.042 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 9.573573e-02 | 1.019 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 9.573573e-02 | 1.019 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 9.573573e-02 | 1.019 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 9.626720e-02 | 1.017 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 9.705874e-02 | 1.013 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.827643e-02 | 1.008 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.002998e-01 | 0.999 |
| R-HSA-3214847 | HATs acetylate histones | 1.002998e-01 | 0.999 |
| R-HSA-9610379 | HCMV Late Events | 1.013901e-01 | 0.994 |
| R-HSA-70171 | Glycolysis | 1.023413e-01 | 0.990 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.033499e-01 | 0.986 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.033499e-01 | 0.986 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.033499e-01 | 0.986 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.033499e-01 | 0.986 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.033499e-01 | 0.986 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.047931e-01 | 0.980 |
| R-HSA-162906 | HIV Infection | 1.052548e-01 | 0.978 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.064738e-01 | 0.973 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.065366e-01 | 0.973 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.106709e-01 | 0.956 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.137603e-01 | 0.944 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.401298e-01 | 0.853 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.401298e-01 | 0.853 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.572748e-01 | 0.803 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.740800e-01 | 0.759 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.740800e-01 | 0.759 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.905521e-01 | 0.720 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.146500e-01 | 0.668 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.146500e-01 | 0.668 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.225231e-01 | 0.653 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.225231e-01 | 0.653 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.225231e-01 | 0.653 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.225231e-01 | 0.653 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.225231e-01 | 0.653 |
| R-HSA-72187 | mRNA 3'-end processing | 1.228479e-01 | 0.911 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.572748e-01 | 0.803 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.905521e-01 | 0.720 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.487452e-01 | 0.828 |
| R-HSA-4641265 | Repression of WNT target genes | 1.487452e-01 | 0.828 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.657195e-01 | 0.781 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.401298e-01 | 0.853 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.401298e-01 | 0.853 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.487452e-01 | 0.828 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.572748e-01 | 0.803 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.572748e-01 | 0.803 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.146500e-01 | 0.668 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.535475e-01 | 0.814 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.657195e-01 | 0.781 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.146500e-01 | 0.668 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.226383e-01 | 0.911 |
| R-HSA-426048 | Arachidonate production from DAG | 1.226383e-01 | 0.911 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.401298e-01 | 0.853 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.905521e-01 | 0.720 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.066977e-01 | 0.685 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.108131e-01 | 0.676 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.108131e-01 | 0.676 |
| R-HSA-9664407 | Parasite infection | 2.108131e-01 | 0.676 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.905521e-01 | 0.720 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.066977e-01 | 0.685 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.137603e-01 | 0.944 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.740800e-01 | 0.759 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.823573e-01 | 0.739 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.146500e-01 | 0.668 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.214356e-01 | 0.916 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.927651e-01 | 0.715 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.476015e-01 | 0.831 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.500642e-01 | 0.824 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.657195e-01 | 0.781 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.740800e-01 | 0.759 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.225231e-01 | 0.653 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.137603e-01 | 0.944 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.657195e-01 | 0.781 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.740800e-01 | 0.759 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.986653e-01 | 0.702 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.711876e-01 | 0.767 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.855301e-01 | 0.732 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.225231e-01 | 0.653 |
| R-HSA-186712 | Regulation of beta-cell development | 1.465973e-01 | 0.834 |
| R-HSA-2028269 | Signaling by Hippo | 1.986653e-01 | 0.702 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.017917e-01 | 0.695 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.082228e-01 | 0.681 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.142090e-01 | 0.669 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.226383e-01 | 0.911 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.487227e-01 | 0.828 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.630487e-01 | 0.788 |
| R-HSA-1181150 | Signaling by NODAL | 2.225231e-01 | 0.653 |
| R-HSA-9830369 | Kidney development | 1.747559e-01 | 0.758 |
| R-HSA-373753 | Nephrin family interactions | 2.225231e-01 | 0.653 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 2.225231e-01 | 0.653 |
| R-HSA-70326 | Glucose metabolism | 1.463766e-01 | 0.835 |
| R-HSA-163685 | Integration of energy metabolism | 2.004969e-01 | 0.698 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 1.465973e-01 | 0.834 |
| R-HSA-449147 | Signaling by Interleukins | 1.181076e-01 | 0.928 |
| R-HSA-72306 | tRNA processing | 1.244199e-01 | 0.905 |
| R-HSA-168256 | Immune System | 1.321277e-01 | 0.879 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.676320e-01 | 0.776 |
| R-HSA-109582 | Hemostasis | 1.889854e-01 | 0.724 |
| R-HSA-211000 | Gene Silencing by RNA | 1.192524e-01 | 0.924 |
| R-HSA-112316 | Neuronal System | 1.218369e-01 | 0.914 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.073402e-01 | 0.683 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.303178e-01 | 0.638 |
| R-HSA-69242 | S Phase | 2.344263e-01 | 0.630 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.361868e-01 | 0.627 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.367963e-01 | 0.626 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.380348e-01 | 0.623 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.380348e-01 | 0.623 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.380348e-01 | 0.623 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.404972e-01 | 0.619 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.404977e-01 | 0.619 |
| R-HSA-8953854 | Metabolism of RNA | 2.447252e-01 | 0.611 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.456749e-01 | 0.610 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.456749e-01 | 0.610 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.479085e-01 | 0.606 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.479085e-01 | 0.606 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.479085e-01 | 0.606 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.516170e-01 | 0.599 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.532389e-01 | 0.596 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.532389e-01 | 0.596 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.532389e-01 | 0.596 |
| R-HSA-9830674 | Formation of the ureteric bud | 2.532389e-01 | 0.596 |
| R-HSA-200425 | Carnitine shuttle | 2.532389e-01 | 0.596 |
| R-HSA-3000170 | Syndecan interactions | 2.532389e-01 | 0.596 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.607274e-01 | 0.584 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.607274e-01 | 0.584 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.607274e-01 | 0.584 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.607274e-01 | 0.584 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.607274e-01 | 0.584 |
| R-HSA-8957322 | Metabolism of steroids | 2.660531e-01 | 0.575 |
| R-HSA-9824446 | Viral Infection Pathways | 2.663528e-01 | 0.575 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.665807e-01 | 0.574 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.681414e-01 | 0.572 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.681414e-01 | 0.572 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.681414e-01 | 0.572 |
| R-HSA-3000157 | Laminin interactions | 2.681414e-01 | 0.572 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.701753e-01 | 0.568 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.738873e-01 | 0.562 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.754814e-01 | 0.560 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.754814e-01 | 0.560 |
| R-HSA-70635 | Urea cycle | 2.754814e-01 | 0.560 |
| R-HSA-1280218 | Adaptive Immune System | 2.778713e-01 | 0.556 |
| R-HSA-1474290 | Collagen formation | 2.813089e-01 | 0.551 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.827483e-01 | 0.549 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.827483e-01 | 0.549 |
| R-HSA-8949613 | Cristae formation | 2.827483e-01 | 0.549 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.827483e-01 | 0.549 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.827483e-01 | 0.549 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.827483e-01 | 0.549 |
| R-HSA-5619102 | SLC transporter disorders | 2.855819e-01 | 0.544 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.899427e-01 | 0.538 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.899427e-01 | 0.538 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.899427e-01 | 0.538 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.899427e-01 | 0.538 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.899427e-01 | 0.538 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.970655e-01 | 0.527 |
| R-HSA-72086 | mRNA Capping | 2.970655e-01 | 0.527 |
| R-HSA-180024 | DARPP-32 events | 2.970655e-01 | 0.527 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.970655e-01 | 0.527 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.970655e-01 | 0.527 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 2.970655e-01 | 0.527 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.970655e-01 | 0.527 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.970655e-01 | 0.527 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.019582e-01 | 0.520 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.041172e-01 | 0.517 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.041172e-01 | 0.517 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.041172e-01 | 0.517 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.041172e-01 | 0.517 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.041172e-01 | 0.517 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.041172e-01 | 0.517 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.074291e-01 | 0.512 |
| R-HSA-186763 | Downstream signal transduction | 3.110986e-01 | 0.507 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.110986e-01 | 0.507 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.110986e-01 | 0.507 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.180103e-01 | 0.498 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.180103e-01 | 0.498 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.248532e-01 | 0.488 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.248532e-01 | 0.488 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.248532e-01 | 0.488 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.248532e-01 | 0.488 |
| R-HSA-9930044 | Nuclear RNA decay | 3.248532e-01 | 0.488 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.248532e-01 | 0.488 |
| R-HSA-9733709 | Cardiogenesis | 3.248532e-01 | 0.488 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.248532e-01 | 0.488 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.248532e-01 | 0.488 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.256279e-01 | 0.487 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.256279e-01 | 0.487 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.292949e-01 | 0.482 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.316278e-01 | 0.479 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.316278e-01 | 0.479 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.316278e-01 | 0.479 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.316278e-01 | 0.479 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.316278e-01 | 0.479 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.383349e-01 | 0.471 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.383349e-01 | 0.471 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.383349e-01 | 0.471 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.383349e-01 | 0.471 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.383349e-01 | 0.471 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.449750e-01 | 0.462 |
| R-HSA-381042 | PERK regulates gene expression | 3.449750e-01 | 0.462 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.449750e-01 | 0.462 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.449750e-01 | 0.462 |
| R-HSA-8853659 | RET signaling | 3.515490e-01 | 0.454 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.515490e-01 | 0.454 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.515490e-01 | 0.454 |
| R-HSA-74160 | Gene expression (Transcription) | 3.522025e-01 | 0.453 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.580573e-01 | 0.446 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.580573e-01 | 0.446 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 3.580573e-01 | 0.446 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.645008e-01 | 0.438 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.708799e-01 | 0.431 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.708799e-01 | 0.431 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 3.708799e-01 | 0.431 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.708799e-01 | 0.431 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.728106e-01 | 0.429 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.771954e-01 | 0.423 |
| R-HSA-167169 | HIV Transcription Elongation | 3.771954e-01 | 0.423 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.771954e-01 | 0.423 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.771954e-01 | 0.423 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.771954e-01 | 0.423 |
| R-HSA-3371568 | Attenuation phase | 3.771954e-01 | 0.423 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.785124e-01 | 0.422 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.799596e-01 | 0.420 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.834479e-01 | 0.416 |
| R-HSA-9607240 | FLT3 Signaling | 3.834479e-01 | 0.416 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.834479e-01 | 0.416 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.834479e-01 | 0.416 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.896381e-01 | 0.409 |
| R-HSA-167161 | HIV Transcription Initiation | 3.896381e-01 | 0.409 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.896381e-01 | 0.409 |
| R-HSA-165159 | MTOR signalling | 3.957664e-01 | 0.403 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 3.957664e-01 | 0.403 |
| R-HSA-195721 | Signaling by WNT | 3.977296e-01 | 0.400 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.011969e-01 | 0.397 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.018336e-01 | 0.396 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.047040e-01 | 0.393 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.078402e-01 | 0.390 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.116889e-01 | 0.385 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.116889e-01 | 0.385 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.116889e-01 | 0.385 |
| R-HSA-194138 | Signaling by VEGF | 4.116889e-01 | 0.385 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.137869e-01 | 0.383 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.137869e-01 | 0.383 |
| R-HSA-69481 | G2/M Checkpoints | 4.186336e-01 | 0.378 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.196743e-01 | 0.377 |
| R-HSA-9675135 | Diseases of DNA repair | 4.196743e-01 | 0.377 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.255028e-01 | 0.371 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.312732e-01 | 0.365 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.312732e-01 | 0.365 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.369860e-01 | 0.360 |
| R-HSA-9748787 | Azathioprine ADME | 4.426418e-01 | 0.354 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.426418e-01 | 0.354 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.482411e-01 | 0.348 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.537844e-01 | 0.343 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.537844e-01 | 0.343 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.537844e-01 | 0.343 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.592725e-01 | 0.338 |
| R-HSA-1221632 | Meiotic synapsis | 4.592725e-01 | 0.338 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.592725e-01 | 0.338 |
| R-HSA-9753281 | Paracetamol ADME | 4.700846e-01 | 0.328 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.700846e-01 | 0.328 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.726186e-01 | 0.325 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.754099e-01 | 0.323 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.754099e-01 | 0.323 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.859013e-01 | 0.313 |
| R-HSA-157118 | Signaling by NOTCH | 4.867482e-01 | 0.313 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.910686e-01 | 0.309 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.910686e-01 | 0.309 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.961842e-01 | 0.304 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.961842e-01 | 0.304 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.961842e-01 | 0.304 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.961842e-01 | 0.304 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.961842e-01 | 0.304 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.961842e-01 | 0.304 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.961842e-01 | 0.304 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.012488e-01 | 0.300 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.012488e-01 | 0.300 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.043705e-01 | 0.297 |
| R-HSA-186797 | Signaling by PDGF | 5.062627e-01 | 0.296 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.062627e-01 | 0.296 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.062627e-01 | 0.296 |
| R-HSA-1268020 | Mitochondrial protein import | 5.062627e-01 | 0.296 |
| R-HSA-9707616 | Heme signaling | 5.062627e-01 | 0.296 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.101154e-01 | 0.292 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.112265e-01 | 0.291 |
| R-HSA-373755 | Semaphorin interactions | 5.112265e-01 | 0.291 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.173269e-01 | 0.286 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.210059e-01 | 0.283 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.265673e-01 | 0.279 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.305908e-01 | 0.275 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.305908e-01 | 0.275 |
| R-HSA-167172 | Transcription of the HIV genome | 5.353115e-01 | 0.271 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.357100e-01 | 0.271 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.434515e-01 | 0.265 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.446118e-01 | 0.264 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.446118e-01 | 0.264 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.446118e-01 | 0.264 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.491924e-01 | 0.260 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.491924e-01 | 0.260 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.491924e-01 | 0.260 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.537272e-01 | 0.257 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.537272e-01 | 0.257 |
| R-HSA-4086398 | Ca2+ pathway | 5.582166e-01 | 0.253 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.582166e-01 | 0.253 |
| R-HSA-5663205 | Infectious disease | 5.601916e-01 | 0.252 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.626612e-01 | 0.250 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.626612e-01 | 0.250 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.626612e-01 | 0.250 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.632150e-01 | 0.249 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.670613e-01 | 0.246 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.670613e-01 | 0.246 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.714174e-01 | 0.243 |
| R-HSA-5689603 | UCH proteinases | 5.714174e-01 | 0.243 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.799993e-01 | 0.237 |
| R-HSA-9658195 | Leishmania infection | 5.852367e-01 | 0.233 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.852367e-01 | 0.233 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.884105e-01 | 0.230 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.925531e-01 | 0.227 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.925531e-01 | 0.227 |
| R-HSA-2559583 | Cellular Senescence | 5.962163e-01 | 0.225 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.007143e-01 | 0.221 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.047338e-01 | 0.218 |
| R-HSA-1500620 | Meiosis | 6.087131e-01 | 0.216 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.126526e-01 | 0.213 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.126526e-01 | 0.213 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.160225e-01 | 0.210 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.171513e-01 | 0.210 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.242360e-01 | 0.205 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.331884e-01 | 0.198 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.354751e-01 | 0.197 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.463801e-01 | 0.190 |
| R-HSA-2029481 | FCGR activation | 6.463801e-01 | 0.190 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.499425e-01 | 0.187 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.534693e-01 | 0.185 |
| R-HSA-72172 | mRNA Splicing | 6.603572e-01 | 0.180 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.604173e-01 | 0.180 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.638391e-01 | 0.178 |
| R-HSA-6805567 | Keratinization | 6.651214e-01 | 0.177 |
| R-HSA-190236 | Signaling by FGFR | 6.672268e-01 | 0.176 |
| R-HSA-1643685 | Disease | 6.689882e-01 | 0.175 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.705804e-01 | 0.174 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.728799e-01 | 0.172 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.739005e-01 | 0.171 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.771874e-01 | 0.169 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.804413e-01 | 0.167 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.804413e-01 | 0.167 |
| R-HSA-111885 | Opioid Signalling | 6.868516e-01 | 0.163 |
| R-HSA-9833110 | RSV-host interactions | 6.900087e-01 | 0.161 |
| R-HSA-418346 | Platelet homeostasis | 6.962283e-01 | 0.157 |
| R-HSA-69239 | Synthesis of DNA | 6.992914e-01 | 0.155 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.992914e-01 | 0.155 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.992914e-01 | 0.155 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.053259e-01 | 0.152 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.078279e-01 | 0.150 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.082978e-01 | 0.150 |
| R-HSA-6798695 | Neutrophil degranulation | 7.112209e-01 | 0.148 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.141526e-01 | 0.146 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.141526e-01 | 0.146 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.161235e-01 | 0.145 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.170361e-01 | 0.144 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.181866e-01 | 0.144 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.198906e-01 | 0.143 |
| R-HSA-212436 | Generic Transcription Pathway | 7.232669e-01 | 0.141 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.233278e-01 | 0.141 |
| R-HSA-597592 | Post-translational protein modification | 7.242875e-01 | 0.140 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.255141e-01 | 0.139 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.337397e-01 | 0.134 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.337397e-01 | 0.134 |
| R-HSA-5693538 | Homology Directed Repair | 7.364268e-01 | 0.133 |
| R-HSA-73894 | DNA Repair | 7.382534e-01 | 0.132 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.390869e-01 | 0.131 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.443273e-01 | 0.128 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.494631e-01 | 0.125 |
| R-HSA-69206 | G1/S Transition | 7.569751e-01 | 0.121 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.594290e-01 | 0.120 |
| R-HSA-114608 | Platelet degranulation | 7.618584e-01 | 0.118 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.642633e-01 | 0.117 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.690010e-01 | 0.114 |
| R-HSA-1474165 | Reproduction | 7.713342e-01 | 0.113 |
| R-HSA-9843745 | Adipogenesis | 7.736440e-01 | 0.111 |
| R-HSA-9909396 | Circadian clock | 7.759306e-01 | 0.110 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.781943e-01 | 0.109 |
| R-HSA-416476 | G alpha (q) signalling events | 7.811730e-01 | 0.107 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.870239e-01 | 0.104 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.877153e-01 | 0.104 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.891761e-01 | 0.103 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.972082e-01 | 0.098 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.095447e-01 | 0.092 |
| R-HSA-166520 | Signaling by NTRKs | 8.133774e-01 | 0.090 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.189831e-01 | 0.087 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.226269e-01 | 0.085 |
| R-HSA-69306 | DNA Replication | 8.226269e-01 | 0.085 |
| R-HSA-9609507 | Protein localization | 8.226269e-01 | 0.085 |
| R-HSA-1989781 | PPARA activates gene expression | 8.261978e-01 | 0.083 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.296973e-01 | 0.081 |
| R-HSA-9679506 | SARS-CoV Infections | 8.345089e-01 | 0.079 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.523087e-01 | 0.069 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.538046e-01 | 0.069 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.567513e-01 | 0.067 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.567513e-01 | 0.067 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.603484e-01 | 0.065 |
| R-HSA-611105 | Respiratory electron transport | 8.638624e-01 | 0.064 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.770490e-01 | 0.057 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.006430e-01 | 0.045 |
| R-HSA-9748784 | Drug ADME | 9.103827e-01 | 0.041 |
| R-HSA-72312 | rRNA processing | 9.223253e-01 | 0.035 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.261955e-01 | 0.033 |
| R-HSA-5688426 | Deubiquitination | 9.386071e-01 | 0.028 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.534413e-01 | 0.021 |
| R-HSA-392499 | Metabolism of proteins | 9.646712e-01 | 0.016 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.746017e-01 | 0.011 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.836935e-01 | 0.007 |
| R-HSA-168249 | Innate Immune System | 9.850501e-01 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.854438e-01 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.858879e-01 | 0.006 |
| R-HSA-418594 | G alpha (i) signalling events | 9.872731e-01 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 9.872731e-01 | 0.006 |
| R-HSA-388396 | GPCR downstream signalling | 9.877795e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.896510e-01 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 9.938983e-01 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 9.980811e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.985834e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.995117e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.996452e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.997949e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GRK1 |
0.771 | 0.316 | -2 | 0.828 |
COT |
0.768 | 0.232 | 2 | 0.815 |
GRK6 |
0.760 | 0.345 | 1 | 0.390 |
GRK7 |
0.759 | 0.240 | 1 | 0.372 |
CDC7 |
0.758 | 0.210 | 1 | 0.350 |
BMPR1B |
0.757 | 0.338 | 1 | 0.471 |
GRK5 |
0.755 | 0.296 | -3 | 0.634 |
GRK3 |
0.754 | 0.324 | -2 | 0.717 |
GRK2 |
0.753 | 0.330 | -2 | 0.740 |
CLK3 |
0.753 | 0.087 | 1 | 0.240 |
NDR2 |
0.751 | 0.085 | -3 | 0.558 |
CK1E |
0.751 | 0.302 | -3 | 0.699 |
RSK2 |
0.751 | 0.101 | -3 | 0.487 |
PIM3 |
0.750 | 0.077 | -3 | 0.555 |
TGFBR1 |
0.749 | 0.234 | -2 | 0.778 |
GRK4 |
0.749 | 0.212 | -2 | 0.828 |
IKKB |
0.748 | 0.057 | -2 | 0.735 |
MTOR |
0.748 | 0.010 | 1 | 0.244 |
MOS |
0.747 | 0.135 | 1 | 0.286 |
DRAK1 |
0.746 | 0.306 | 1 | 0.519 |
CK1A2 |
0.746 | 0.297 | -3 | 0.685 |
CAMK2B |
0.746 | 0.131 | 2 | 0.689 |
CAMK2G |
0.745 | 0.077 | 2 | 0.734 |
CK2A1 |
0.745 | 0.258 | 1 | 0.441 |
TBK1 |
0.744 | -0.043 | 1 | 0.217 |
CK1D |
0.743 | 0.289 | -3 | 0.687 |
SKMLCK |
0.743 | 0.115 | -2 | 0.834 |
IKKA |
0.743 | 0.083 | -2 | 0.730 |
ALK4 |
0.743 | 0.215 | -2 | 0.797 |
CK2A2 |
0.742 | 0.216 | 1 | 0.420 |
BMPR1A |
0.742 | 0.266 | 1 | 0.450 |
GSK3A |
0.742 | 0.235 | 4 | 0.750 |
PLK1 |
0.742 | 0.197 | -2 | 0.761 |
MAPKAPK2 |
0.742 | 0.049 | -3 | 0.480 |
RAF1 |
0.742 | 0.021 | 1 | 0.273 |
GSK3B |
0.742 | 0.247 | 4 | 0.742 |
KIS |
0.741 | 0.027 | 1 | 0.153 |
DSTYK |
0.741 | 0.035 | 2 | 0.812 |
GCN2 |
0.740 | -0.026 | 2 | 0.745 |
ACVR2B |
0.740 | 0.259 | -2 | 0.762 |
IKKE |
0.740 | -0.050 | 1 | 0.213 |
MSK1 |
0.740 | 0.083 | -3 | 0.487 |
RSK4 |
0.740 | 0.099 | -3 | 0.475 |
PKACG |
0.739 | 0.044 | -2 | 0.751 |
CLK2 |
0.739 | 0.091 | -3 | 0.482 |
PIM1 |
0.739 | 0.045 | -3 | 0.536 |
P90RSK |
0.739 | 0.053 | -3 | 0.485 |
ACVR2A |
0.739 | 0.259 | -2 | 0.743 |
CAMK2A |
0.739 | 0.115 | 2 | 0.698 |
CAMK1B |
0.738 | 0.022 | -3 | 0.558 |
PRPK |
0.738 | -0.022 | -1 | 0.849 |
NDR1 |
0.737 | 0.016 | -3 | 0.548 |
NLK |
0.737 | -0.007 | 1 | 0.236 |
PKN3 |
0.737 | -0.018 | -3 | 0.536 |
PDHK4 |
0.736 | -0.071 | 1 | 0.258 |
NEK7 |
0.736 | -0.032 | -3 | 0.586 |
DLK |
0.735 | 0.159 | 1 | 0.314 |
MST4 |
0.735 | 0.008 | 2 | 0.785 |
CDK1 |
0.735 | 0.013 | 1 | 0.219 |
LATS2 |
0.735 | 0.028 | -5 | 0.783 |
HUNK |
0.735 | 0.011 | 2 | 0.793 |
ULK2 |
0.734 | -0.072 | 2 | 0.749 |
ATR |
0.734 | -0.033 | 1 | 0.231 |
P70S6KB |
0.734 | 0.031 | -3 | 0.510 |
MLK1 |
0.734 | 0.030 | 2 | 0.762 |
CAMK2D |
0.733 | 0.028 | -3 | 0.551 |
MSK2 |
0.733 | 0.024 | -3 | 0.492 |
RIPK3 |
0.733 | -0.002 | 3 | 0.587 |
PRKX |
0.733 | 0.073 | -3 | 0.441 |
PASK |
0.733 | 0.208 | -3 | 0.580 |
CK1G1 |
0.733 | 0.223 | -3 | 0.660 |
PKN2 |
0.733 | 0.004 | -3 | 0.563 |
DAPK2 |
0.732 | 0.078 | -3 | 0.561 |
CHAK2 |
0.732 | -0.000 | -1 | 0.839 |
CK1A |
0.732 | 0.319 | -3 | 0.640 |
MAPKAPK3 |
0.731 | -0.011 | -3 | 0.505 |
ALK2 |
0.731 | 0.157 | -2 | 0.785 |
NEK6 |
0.731 | -0.047 | -2 | 0.808 |
CDKL1 |
0.731 | -0.019 | -3 | 0.522 |
SRPK1 |
0.731 | -0.015 | -3 | 0.486 |
BMPR2 |
0.731 | -0.019 | -2 | 0.830 |
TGFBR2 |
0.731 | 0.037 | -2 | 0.762 |
ULK1 |
0.731 | -0.042 | -3 | 0.560 |
MASTL |
0.731 | 0.004 | -2 | 0.797 |
WNK1 |
0.731 | -0.042 | -2 | 0.827 |
PKACB |
0.730 | 0.046 | -2 | 0.675 |
ERK5 |
0.730 | -0.039 | 1 | 0.207 |
RSK3 |
0.730 | 0.001 | -3 | 0.470 |
CAMLCK |
0.730 | 0.021 | -2 | 0.811 |
AURC |
0.730 | 0.052 | -2 | 0.651 |
JNK2 |
0.729 | 0.008 | 1 | 0.176 |
AURA |
0.729 | 0.067 | -2 | 0.638 |
AMPKA1 |
0.729 | -0.021 | -3 | 0.567 |
LATS1 |
0.729 | 0.077 | -3 | 0.545 |
NIK |
0.729 | -0.028 | -3 | 0.582 |
PRKD2 |
0.729 | -0.012 | -3 | 0.501 |
PRKD1 |
0.728 | -0.027 | -3 | 0.532 |
CDK8 |
0.727 | -0.028 | 1 | 0.167 |
ICK |
0.727 | 0.000 | -3 | 0.549 |
CAMK4 |
0.727 | -0.015 | -3 | 0.545 |
P38G |
0.727 | -0.003 | 1 | 0.168 |
JNK3 |
0.726 | -0.000 | 1 | 0.181 |
DYRK2 |
0.726 | -0.010 | 1 | 0.163 |
PAK1 |
0.726 | 0.009 | -2 | 0.756 |
TTBK2 |
0.726 | -0.021 | 2 | 0.675 |
CLK4 |
0.726 | 0.026 | -3 | 0.495 |
PKCD |
0.726 | -0.020 | 2 | 0.730 |
PLK3 |
0.726 | 0.038 | 2 | 0.706 |
SRPK2 |
0.726 | -0.019 | -3 | 0.433 |
NUAK2 |
0.725 | -0.019 | -3 | 0.555 |
CDK19 |
0.725 | -0.027 | 1 | 0.154 |
MYLK4 |
0.725 | 0.061 | -2 | 0.753 |
CDKL5 |
0.725 | -0.029 | -3 | 0.513 |
FAM20C |
0.725 | 0.030 | 2 | 0.522 |
ATM |
0.725 | -0.027 | 1 | 0.220 |
HIPK4 |
0.725 | -0.033 | 1 | 0.168 |
AMPKA2 |
0.724 | -0.028 | -3 | 0.541 |
CDK2 |
0.723 | -0.007 | 1 | 0.273 |
PDHK1 |
0.723 | -0.180 | 1 | 0.222 |
AURB |
0.723 | 0.034 | -2 | 0.655 |
HIPK2 |
0.723 | -0.008 | 1 | 0.130 |
CDK3 |
0.722 | -0.015 | 1 | 0.176 |
YSK4 |
0.722 | -0.007 | 1 | 0.244 |
NEK9 |
0.722 | -0.083 | 2 | 0.789 |
CDK18 |
0.722 | -0.027 | 1 | 0.164 |
DNAPK |
0.722 | -0.038 | 1 | 0.174 |
CDK17 |
0.722 | -0.026 | 1 | 0.175 |
P38B |
0.721 | -0.008 | 1 | 0.167 |
MEK1 |
0.721 | 0.110 | 2 | 0.779 |
SGK3 |
0.721 | -0.001 | -3 | 0.492 |
ANKRD3 |
0.721 | -0.038 | 1 | 0.257 |
CLK1 |
0.721 | 0.002 | -3 | 0.467 |
RIPK1 |
0.721 | -0.057 | 1 | 0.237 |
ERK1 |
0.720 | -0.017 | 1 | 0.154 |
PKG2 |
0.720 | 0.016 | -2 | 0.672 |
MLK4 |
0.720 | 0.041 | 2 | 0.668 |
MLK3 |
0.719 | -0.007 | 2 | 0.688 |
MLK2 |
0.719 | -0.067 | 2 | 0.765 |
MARK4 |
0.719 | -0.069 | 4 | 0.679 |
PKCB |
0.719 | -0.012 | 2 | 0.686 |
TLK2 |
0.719 | 0.003 | 1 | 0.206 |
NIM1 |
0.719 | -0.062 | 3 | 0.608 |
WNK3 |
0.719 | -0.147 | 1 | 0.211 |
PKCG |
0.719 | -0.013 | 2 | 0.692 |
MNK2 |
0.718 | -0.014 | -2 | 0.756 |
MNK1 |
0.718 | -0.003 | -2 | 0.761 |
SRPK3 |
0.718 | -0.025 | -3 | 0.475 |
BCKDK |
0.718 | -0.107 | -1 | 0.811 |
DYRK4 |
0.718 | -0.006 | 1 | 0.151 |
DAPK1 |
0.718 | 0.122 | -3 | 0.520 |
PAK3 |
0.718 | -0.039 | -2 | 0.746 |
AKT2 |
0.718 | 0.001 | -3 | 0.438 |
CDK5 |
0.717 | -0.028 | 1 | 0.183 |
JNK1 |
0.717 | 0.009 | 1 | 0.202 |
PAK2 |
0.717 | -0.012 | -2 | 0.742 |
MELK |
0.716 | -0.057 | -3 | 0.517 |
CAMK1G |
0.716 | -0.020 | -3 | 0.494 |
TSSK2 |
0.716 | -0.028 | -5 | 0.833 |
BRSK1 |
0.716 | -0.001 | -3 | 0.505 |
CDK13 |
0.716 | -0.045 | 1 | 0.165 |
CDK7 |
0.716 | -0.047 | 1 | 0.173 |
PKACA |
0.716 | 0.022 | -2 | 0.627 |
MST3 |
0.716 | 0.076 | 2 | 0.785 |
TSSK1 |
0.716 | -0.047 | -3 | 0.571 |
P38A |
0.715 | -0.024 | 1 | 0.173 |
ERK2 |
0.715 | -0.029 | 1 | 0.175 |
MEKK3 |
0.715 | 0.087 | 1 | 0.270 |
PKCH |
0.715 | -0.026 | 2 | 0.686 |
DCAMKL1 |
0.715 | -0.016 | -3 | 0.506 |
HIPK1 |
0.715 | -0.015 | 1 | 0.164 |
PKR |
0.714 | -0.036 | 1 | 0.206 |
PLK4 |
0.714 | -0.049 | 2 | 0.650 |
PKCA |
0.714 | -0.030 | 2 | 0.683 |
PAK6 |
0.713 | -0.013 | -2 | 0.663 |
IRE1 |
0.713 | -0.088 | 1 | 0.174 |
CDK14 |
0.713 | -0.028 | 1 | 0.186 |
CDK16 |
0.713 | -0.028 | 1 | 0.170 |
SMG1 |
0.713 | -0.053 | 1 | 0.188 |
CDK12 |
0.712 | -0.045 | 1 | 0.160 |
CDK10 |
0.712 | -0.013 | 1 | 0.181 |
MAPKAPK5 |
0.711 | -0.067 | -3 | 0.471 |
PKCZ |
0.711 | -0.057 | 2 | 0.740 |
PIM2 |
0.711 | -0.008 | -3 | 0.472 |
PHKG1 |
0.710 | -0.082 | -3 | 0.551 |
DYRK1A |
0.710 | -0.034 | 1 | 0.174 |
CHAK1 |
0.710 | -0.097 | 2 | 0.748 |
DYRK1B |
0.710 | -0.024 | 1 | 0.171 |
VRK2 |
0.710 | -0.100 | 1 | 0.228 |
MARK3 |
0.710 | -0.019 | 4 | 0.626 |
NEK2 |
0.710 | -0.115 | 2 | 0.775 |
QSK |
0.710 | -0.049 | 4 | 0.643 |
P70S6K |
0.709 | -0.007 | -3 | 0.445 |
DAPK3 |
0.709 | 0.056 | -3 | 0.525 |
P38D |
0.709 | -0.021 | 1 | 0.109 |
TAO3 |
0.709 | 0.015 | 1 | 0.253 |
QIK |
0.708 | -0.084 | -3 | 0.542 |
ZAK |
0.708 | -0.035 | 1 | 0.251 |
GAK |
0.708 | 0.081 | 1 | 0.251 |
CDK9 |
0.708 | -0.063 | 1 | 0.167 |
PLK2 |
0.707 | 0.045 | -3 | 0.508 |
PRKD3 |
0.707 | -0.062 | -3 | 0.462 |
BRSK2 |
0.707 | -0.069 | -3 | 0.527 |
SIK |
0.706 | -0.067 | -3 | 0.489 |
AKT1 |
0.706 | -0.016 | -3 | 0.456 |
DYRK3 |
0.706 | -0.019 | 1 | 0.152 |
PAK4 |
0.706 | 0.002 | -2 | 0.639 |
CHK1 |
0.706 | -0.066 | -3 | 0.520 |
SMMLCK |
0.705 | 0.013 | -3 | 0.527 |
DCAMKL2 |
0.705 | -0.042 | -3 | 0.511 |
PRP4 |
0.705 | -0.029 | -3 | 0.523 |
GCK |
0.705 | 0.072 | 1 | 0.293 |
PAK5 |
0.705 | -0.017 | -2 | 0.630 |
SNRK |
0.704 | -0.103 | 2 | 0.701 |
MARK2 |
0.704 | -0.043 | 4 | 0.589 |
NUAK1 |
0.704 | -0.090 | -3 | 0.501 |
CAMK1D |
0.704 | -0.017 | -3 | 0.430 |
SGK1 |
0.704 | 0.012 | -3 | 0.389 |
BRAF |
0.704 | -0.032 | -4 | 0.771 |
PERK |
0.703 | -0.066 | -2 | 0.788 |
NEK11 |
0.703 | -0.016 | 1 | 0.275 |
MEK5 |
0.703 | -0.055 | 2 | 0.771 |
MARK1 |
0.702 | -0.041 | 4 | 0.638 |
IRE2 |
0.702 | -0.122 | 2 | 0.726 |
TTBK1 |
0.701 | -0.067 | 2 | 0.607 |
TLK1 |
0.701 | -0.051 | -2 | 0.812 |
NEK5 |
0.701 | -0.108 | 1 | 0.209 |
MEKK1 |
0.700 | -0.113 | 1 | 0.208 |
YANK3 |
0.700 | 0.071 | 2 | 0.374 |
MPSK1 |
0.700 | -0.032 | 1 | 0.159 |
MEKK2 |
0.700 | -0.034 | 2 | 0.755 |
MST2 |
0.699 | 0.015 | 1 | 0.262 |
WNK4 |
0.699 | -0.107 | -2 | 0.808 |
MRCKA |
0.699 | 0.009 | -3 | 0.483 |
HIPK3 |
0.698 | -0.066 | 1 | 0.144 |
HPK1 |
0.698 | 0.040 | 1 | 0.284 |
PKCE |
0.698 | -0.012 | 2 | 0.683 |
PKCT |
0.698 | -0.071 | 2 | 0.692 |
NEK8 |
0.698 | -0.060 | 2 | 0.785 |
MAK |
0.698 | 0.010 | -2 | 0.717 |
AKT3 |
0.697 | -0.010 | -3 | 0.406 |
TAK1 |
0.696 | 0.047 | 1 | 0.254 |
HRI |
0.696 | -0.158 | -2 | 0.790 |
PHKG2 |
0.696 | -0.100 | -3 | 0.509 |
PDK1 |
0.696 | -0.057 | 1 | 0.241 |
EEF2K |
0.695 | -0.010 | 3 | 0.670 |
CK1G3 |
0.695 | 0.210 | -3 | 0.607 |
VRK1 |
0.694 | 0.009 | 2 | 0.827 |
CAMKK2 |
0.694 | -0.053 | -2 | 0.700 |
CAMKK1 |
0.694 | -0.079 | -2 | 0.694 |
STK33 |
0.693 | -0.044 | 2 | 0.594 |
ROCK2 |
0.693 | 0.012 | -3 | 0.513 |
IRAK4 |
0.693 | -0.130 | 1 | 0.167 |
PKCI |
0.693 | -0.052 | 2 | 0.708 |
CDK6 |
0.692 | -0.056 | 1 | 0.155 |
MST1 |
0.692 | -0.032 | 1 | 0.241 |
CDK4 |
0.692 | -0.052 | 1 | 0.153 |
MRCKB |
0.692 | -0.014 | -3 | 0.471 |
MAP3K15 |
0.691 | -0.070 | 1 | 0.227 |
CK1G2 |
0.691 | 0.215 | -3 | 0.641 |
TAO2 |
0.691 | -0.088 | 2 | 0.795 |
MINK |
0.690 | -0.046 | 1 | 0.224 |
CAMK1A |
0.690 | -0.038 | -3 | 0.414 |
PINK1 |
0.689 | -0.175 | 1 | 0.186 |
ERK7 |
0.689 | -0.026 | 2 | 0.525 |
CHK2 |
0.689 | -0.037 | -3 | 0.400 |
PKN1 |
0.689 | -0.062 | -3 | 0.459 |
LKB1 |
0.687 | -0.102 | -3 | 0.575 |
KHS2 |
0.687 | -0.005 | 1 | 0.247 |
SSTK |
0.687 | -0.080 | 4 | 0.621 |
MOK |
0.687 | -0.018 | 1 | 0.149 |
SLK |
0.686 | -0.056 | -2 | 0.727 |
LOK |
0.685 | -0.085 | -2 | 0.751 |
TNIK |
0.684 | -0.081 | 3 | 0.691 |
NEK4 |
0.684 | -0.150 | 1 | 0.187 |
DMPK1 |
0.684 | 0.007 | -3 | 0.494 |
LRRK2 |
0.684 | -0.095 | 2 | 0.809 |
HGK |
0.683 | -0.103 | 3 | 0.682 |
KHS1 |
0.683 | -0.061 | 1 | 0.216 |
OSR1 |
0.683 | 0.009 | 2 | 0.743 |
MEKK6 |
0.682 | -0.131 | 1 | 0.205 |
IRAK1 |
0.681 | -0.174 | -1 | 0.772 |
PBK |
0.680 | -0.062 | 1 | 0.168 |
ROCK1 |
0.680 | -0.015 | -3 | 0.487 |
NEK1 |
0.680 | -0.153 | 1 | 0.197 |
CRIK |
0.680 | -0.009 | -3 | 0.457 |
MEK2 |
0.679 | -0.110 | 2 | 0.765 |
RIPK2 |
0.679 | -0.144 | 1 | 0.224 |
PDHK3_TYR |
0.678 | 0.211 | 4 | 0.769 |
SBK |
0.676 | -0.039 | -3 | 0.358 |
PKG1 |
0.676 | -0.045 | -2 | 0.583 |
YSK1 |
0.676 | -0.103 | 2 | 0.760 |
HASPIN |
0.674 | -0.024 | -1 | 0.712 |
PDHK4_TYR |
0.674 | 0.177 | 2 | 0.800 |
BUB1 |
0.673 | -0.056 | -5 | 0.790 |
BMPR2_TYR |
0.672 | 0.189 | -1 | 0.855 |
YANK2 |
0.671 | 0.069 | 2 | 0.379 |
MAP2K6_TYR |
0.671 | 0.210 | -1 | 0.862 |
TTK |
0.669 | -0.030 | -2 | 0.786 |
TXK |
0.668 | 0.234 | 1 | 0.404 |
ALPHAK3 |
0.668 | -0.002 | -1 | 0.751 |
BIKE |
0.668 | -0.060 | 1 | 0.181 |
PDHK1_TYR |
0.667 | 0.131 | -1 | 0.868 |
MAP2K4_TYR |
0.665 | 0.063 | -1 | 0.861 |
ASK1 |
0.665 | -0.118 | 1 | 0.229 |
TAO1 |
0.663 | -0.113 | 1 | 0.186 |
MAP2K7_TYR |
0.662 | -0.054 | 2 | 0.808 |
MYO3B |
0.662 | -0.104 | 2 | 0.772 |
TESK1_TYR |
0.661 | -0.048 | 3 | 0.708 |
STLK3 |
0.661 | -0.084 | 1 | 0.226 |
NEK3 |
0.661 | -0.188 | 1 | 0.157 |
MYO3A |
0.661 | -0.102 | 1 | 0.193 |
PINK1_TYR |
0.660 | -0.055 | 1 | 0.268 |
EPHB4 |
0.658 | 0.042 | -1 | 0.850 |
YES1 |
0.656 | 0.011 | -1 | 0.849 |
SYK |
0.656 | 0.181 | -1 | 0.753 |
PKMYT1_TYR |
0.656 | -0.086 | 3 | 0.688 |
AAK1 |
0.656 | -0.049 | 1 | 0.133 |
SRMS |
0.656 | 0.106 | 1 | 0.353 |
INSRR |
0.655 | 0.049 | 3 | 0.566 |
FGR |
0.654 | 0.030 | 1 | 0.293 |
EPHB1 |
0.653 | 0.061 | 1 | 0.329 |
PTK2 |
0.653 | 0.183 | -1 | 0.777 |
LIMK2_TYR |
0.652 | -0.113 | -3 | 0.586 |
EPHA6 |
0.652 | -0.011 | -1 | 0.853 |
RET |
0.652 | -0.146 | 1 | 0.218 |
DDR1 |
0.651 | -0.090 | 4 | 0.673 |
EPHA4 |
0.651 | 0.029 | 2 | 0.709 |
EPHB2 |
0.651 | 0.045 | -1 | 0.834 |
MERTK |
0.651 | 0.056 | 3 | 0.594 |
FER |
0.650 | -0.001 | 1 | 0.312 |
ITK |
0.650 | 0.062 | -1 | 0.815 |
FYN |
0.650 | 0.062 | -1 | 0.802 |
BMX |
0.649 | 0.084 | -1 | 0.738 |
ABL2 |
0.649 | -0.024 | -1 | 0.811 |
PTK2B |
0.649 | 0.129 | -1 | 0.792 |
MST1R |
0.648 | -0.155 | 3 | 0.630 |
CSF1R |
0.648 | -0.092 | 3 | 0.599 |
FGFR2 |
0.647 | -0.081 | 3 | 0.626 |
TYRO3 |
0.647 | -0.076 | 3 | 0.602 |
ABL1 |
0.647 | -0.028 | -1 | 0.805 |
FLT1 |
0.647 | 0.007 | -1 | 0.819 |
EGFR |
0.646 | 0.010 | 1 | 0.299 |
JAK3 |
0.646 | -0.101 | 1 | 0.239 |
TNK2 |
0.645 | -0.070 | 3 | 0.586 |
KDR |
0.645 | -0.070 | 3 | 0.574 |
EPHB3 |
0.645 | -0.011 | -1 | 0.837 |
LIMK1_TYR |
0.645 | -0.171 | 2 | 0.810 |
ERBB2 |
0.645 | -0.019 | 1 | 0.298 |
ROS1 |
0.645 | -0.124 | 3 | 0.581 |
NTRK1 |
0.645 | -0.011 | -1 | 0.827 |
KIT |
0.645 | -0.050 | 3 | 0.603 |
TYK2 |
0.644 | -0.234 | 1 | 0.202 |
PDGFRB |
0.643 | -0.107 | 3 | 0.610 |
MET |
0.643 | -0.012 | 3 | 0.597 |
DDR2 |
0.643 | -0.024 | 3 | 0.557 |
HCK |
0.643 | -0.056 | -1 | 0.831 |
TEC |
0.642 | 0.023 | -1 | 0.755 |
ERBB4 |
0.642 | 0.071 | 1 | 0.350 |
NEK10_TYR |
0.642 | -0.140 | 1 | 0.175 |
FGFR3 |
0.642 | -0.046 | 3 | 0.596 |
EPHA5 |
0.642 | 0.034 | 2 | 0.698 |
JAK2 |
0.641 | -0.209 | 1 | 0.198 |
EPHA7 |
0.641 | 0.005 | 2 | 0.719 |
LCK |
0.641 | -0.047 | -1 | 0.830 |
FLT3 |
0.641 | -0.122 | 3 | 0.601 |
BLK |
0.641 | -0.039 | -1 | 0.828 |
AXL |
0.640 | -0.056 | 3 | 0.582 |
WEE1_TYR |
0.639 | -0.037 | -1 | 0.762 |
EPHA8 |
0.639 | 0.019 | -1 | 0.803 |
NTRK3 |
0.639 | -0.018 | -1 | 0.777 |
FRK |
0.638 | -0.037 | -1 | 0.832 |
EPHA3 |
0.638 | -0.020 | 2 | 0.694 |
SRC |
0.638 | 0.010 | -1 | 0.800 |
INSR |
0.637 | -0.042 | 3 | 0.550 |
BTK |
0.637 | -0.071 | -1 | 0.790 |
FGFR1 |
0.637 | -0.142 | 3 | 0.579 |
FLT4 |
0.636 | -0.089 | 3 | 0.592 |
TNK1 |
0.636 | -0.145 | 3 | 0.602 |
NTRK2 |
0.634 | -0.086 | 3 | 0.562 |
LTK |
0.634 | -0.087 | 3 | 0.571 |
ZAP70 |
0.634 | 0.073 | -1 | 0.685 |
JAK1 |
0.634 | -0.155 | 1 | 0.197 |
ALK |
0.633 | -0.083 | 3 | 0.535 |
PDGFRA |
0.633 | -0.187 | 3 | 0.611 |
TEK |
0.633 | -0.141 | 3 | 0.548 |
MATK |
0.633 | -0.018 | -1 | 0.734 |
FGFR4 |
0.632 | -0.032 | -1 | 0.768 |
MUSK |
0.632 | -0.050 | 1 | 0.284 |
PTK6 |
0.631 | -0.115 | -1 | 0.745 |
EPHA1 |
0.631 | -0.094 | 3 | 0.579 |
IGF1R |
0.630 | -0.002 | 3 | 0.496 |
EPHA2 |
0.628 | 0.011 | -1 | 0.777 |
CSK |
0.628 | -0.046 | 2 | 0.725 |
LYN |
0.626 | -0.079 | 3 | 0.546 |
FES |
0.625 | 0.075 | -1 | 0.713 |
TNNI3K_TYR |
0.624 | -0.172 | 1 | 0.149 |