Motif 42 (n=167)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A7E2V4 | ZSWIM8 | S437 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| O15014 | ZNF609 | S1216 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15061 | SYNM | S1181 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15350 | TP73 | S412 | ochoa | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O15400 | STX7 | S45 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O43795 | MYO1B | S893 | ochoa | Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa) | Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. {ECO:0000250}. |
| O60244 | MED14 | S1128 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60469 | DSCAM | S1934 | ochoa | Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule) | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:F1NY98, ECO:0000250|UniProtKB:Q9ERC8, ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}. |
| O60732 | MAGEC1 | S86 | ochoa | Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen) | None |
| O75128 | COBL | S455 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75151 | PHF2 | S655 | ochoa|psp | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75376 | NCOR1 | S1533 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94769 | ECM2 | S304 | ochoa | Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2) | Promotes matrix assembly and cell adhesiveness. {ECO:0000250|UniProtKB:Q5FW85}. |
| O94953 | KDM4B | S622 | psp | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| P00519 | ABL1 | S569 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P01042 | KNG1 | S275 | ochoa | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}. |
| P03372 | ESR1 | S294 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P05089 | ARG1 | S62 | ochoa | Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase) | Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. {ECO:0000305}.; FUNCTION: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. {ECO:0000250|UniProtKB:Q61176, ECO:0000269|PubMed:15546957, ECO:0000269|PubMed:16709924, ECO:0000269|PubMed:19380772}. |
| P09017 | HOXC4 | S33 | ochoa | Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P25054 | APC | S2449 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27037 | ACVR2A | S184 | ochoa | Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401, PubMed:10652306). Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250|UniProtKB:P27038, ECO:0000269|PubMed:1314589, ECO:0000269|PubMed:17911401}. |
| P43364 | MAGEA11 | S208 | ochoa|psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P46013 | MKI67 | S2708 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | S1400 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47736 | RAP1GAP | S74 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49366 | DHPS | S233 | psp | Deoxyhypusine synthase (DHS) (EC 2.5.1.46) | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000269|PubMed:30661771}. |
| P49790 | NUP153 | S209 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51812 | RPS6KA3 | S369 | ochoa|psp | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| P54198 | HIRA | S687 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P54278 | PMS2 | S445 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P54920 | NAPA | S195 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P56524 | HDAC4 | S266 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P57682 | KLF3 | S250 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P78347 | GTF2I | S515 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78347 | GTF2I | S620 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| Q01432 | AMPD3 | S107 | ochoa | AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) | AMP deaminase plays a critical role in energy metabolism. {ECO:0000305|PubMed:9291127}. |
| Q08050 | FOXM1 | S710 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q08174 | PCDH1 | S949 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q09666 | AHNAK | S5110 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5430 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S983 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12774 | ARHGEF5 | S1405 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13233 | MAP3K1 | S1018 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13637 | RAB32 | S134 | ochoa | Ras-related protein Rab-32 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:11784320, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:23084991, ECO:0000269|PubMed:38127736}. |
| Q14596 | NBR1 | S596 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14669 | TRIP12 | S1016 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14676 | MDC1 | S1068 | ochoa|psp | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14687 | GSE1 | S43 | ochoa | Genetic suppressor element 1 | None |
| Q14789 | GOLGB1 | S2872 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14966 | ZNF638 | S383 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15366 | PCBP2 | S189 | ochoa|psp | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15418 | RPS6KA1 | S363 | ochoa|psp | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q15652 | JMJD1C | S1748 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15744 | CEBPE | S181 | ochoa | CCAAT/enhancer-binding protein epsilon (C/EBP epsilon) | Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). {ECO:0000269|PubMed:10359588, ECO:0000269|PubMed:26019275}. |
| Q15797 | SMAD1 | S151 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16513 | PKN2 | S213 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q2M2I8 | AAK1 | S624 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q2M3V2 | SOWAHA | S252 | ochoa | Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) | None |
| Q2NKX8 | ERCC6L | S755 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q5FBB7 | SGO1 | S436 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5JTD0 | TJAP1 | S345 | ochoa | Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) | Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}. |
| Q5T0Z8 | C6orf132 | S558 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T5P2 | KIAA1217 | S474 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TB30 | DEPDC1 | S110 | ochoa|psp | DEP domain-containing protein 1A | May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}. |
| Q5TGY3 | AHDC1 | S1403 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TH69 | ARFGEF3 | S1066 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5TH69 | ARFGEF3 | S2061 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5THJ4 | VPS13D | S2079 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5THK1 | PRR14L | S437 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5VUA4 | ZNF318 | S1043 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q68CZ2 | TNS3 | S969 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68D20 | PMS2CL | S59 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
| Q6GYQ0 | RALGAPA1 | S1478 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6P0Q8 | MAST2 | S66 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P0Q8 | MAST2 | S1399 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6V0I7 | FAT4 | S4655 | ochoa | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}. |
| Q6ZN04 | MEX3B | S442 | ochoa | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms. |
| Q6ZN55 | ZNF574 | S534 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q7Z4H7 | HAUS6 | S406 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z6M1 | RABEPK | S27 | ochoa | Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) | Rab9 effector required for endosome to trans-Golgi network (TGN) transport. {ECO:0000269|PubMed:9230071}. |
| Q86W56 | PARG | S448 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q86YC2 | PALB2 | S190 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q86YV5 | PRAG1 | S148 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IU60 | DCP2 | S284 | ochoa | m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) | Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12218187, PubMed:12417715, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:28002401}. |
| Q8IWB9 | TEX2 | S91 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IXQ3 | C9orf40 | S69 | ochoa | Uncharacterized protein C9orf40 | None |
| Q8IY33 | MICALL2 | S494 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IYP9 | ZDHHC23 | S252 | ochoa | Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. {ECO:0000269|PubMed:22399288, ECO:0000305|PubMed:22399288}. |
| Q8IZD0 | SAMD14 | S117 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8IZT6 | ASPM | S392 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N157 | AHI1 | S1127 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8N1G4 | LRRC47 | S92 | ochoa | Leucine-rich repeat-containing protein 47 | None |
| Q8N344 | MIER2 | S467 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N4C8 | MINK1 | S918 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4X5 | AFAP1L2 | S640 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N6T3 | ARFGAP1 | S304 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8NBZ0 | INO80E | S154 | ochoa|psp | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q8NDX5 | PHC3 | S315 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEY1 | NAV1 | S362 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NG31 | KNL1 | S32 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NHQ8 | RASSF8 | S385 | ochoa | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | None |
| Q8TBB5 | KLHDC4 | S62 | ochoa | Kelch domain-containing protein 4 | None |
| Q8TDF6 | RASGRP4 | S184 | ochoa | RAS guanyl-releasing protein 4 | Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity). {ECO:0000250|UniProtKB:Q8BTM9, ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}. |
| Q8TE68 | EPS8L1 | S631 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8WUY3 | PRUNE2 | S754 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WXI9 | GATAD2B | S213 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q92540 | SMG7 | S520 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92560 | BAP1 | S327 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92576 | PHF3 | S129 | ochoa | PHD finger protein 3 | None |
| Q92731 | ESR2 | S105 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q92750 | TAF4B | S64 | ochoa | Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) | Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}. |
| Q92918 | MAP4K1 | S737 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q969V6 | MRTFA | S482 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96DF8 | ESS2 | S292 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96DF8 | ESS2 | S395 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96FZ5 | CMTM7 | S30 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) | None |
| Q96G28 | CFAP36 | S85 | ochoa | Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) | May act as an effector for ARL3. |
| Q96P48 | ARAP1 | S632 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}. |
| Q96S90 | LYSMD1 | S194 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q99717 | SMAD5 | S152 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q99973 | TEP1 | S397 | ochoa | Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) | Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). {ECO:0000250|UniProtKB:P97499, ECO:0000269|PubMed:19179534}. |
| Q9BQ52 | ELAC2 | S736 | ochoa | Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}. |
| Q9BUA3 | SPINDOC | S55 | ochoa | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}. |
| Q9BVI0 | PHF20 | S488 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BY77 | POLDIP3 | S275 | ochoa|psp | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BY89 | KIAA1671 | S969 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYM8 | RBCK1 | S50 | ochoa | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9BYX2 | TBC1D2 | S436 | ochoa | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}. |
| Q9C0D5 | TANC1 | S29 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H6K1 | ILRUN | S215 | ochoa|psp | Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) | Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}. |
| Q9H6S3 | EPS8L2 | S480 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9HCE6 | ARHGEF10L | S138 | ochoa | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}. |
| Q9NSY1 | BMP2K | S1076 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NXF7 | DCAF16 | S130 | ochoa | DDB1- and CUL4-associated factor 16 | Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31209349}. |
| Q9NXL9 | MCM9 | S883 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NXL9 | MCM9 | S915 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NZ52 | GGA3 | S538 | ochoa|psp | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
| Q9NZ63 | C9orf78 | S261 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9NZM1 | MYOF | S1915 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9NZM3 | ITSN2 | S110 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P107 | GMIP | S923 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P275 | USP36 | S807 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2J5 | LARS1 | S396 | ochoa | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q9UHB7 | AFF4 | S32 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHR4 | BAIAP2L1 | S261 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UIF9 | BAZ2A | S509 | ochoa|psp | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UK32 | RPS6KA6 | S372 | ochoa|psp | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9UKL0 | RCOR1 | S460 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9UKV0 | HDAC9 | S240 | ochoa | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9ULU4 | ZMYND8 | S547 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMS6 | SYNPO2 | S705 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMS6 | SYNPO2 | S930 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPW6 | SATB2 | S294 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9UPW6 | SATB2 | S303 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9UPZ3 | HPS5 | S532 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9UQL6 | HDAC5 | S279 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y276 | BCS1L | Y181 | ochoa | Mitochondrial chaperone BCS1 (h-BCS1) (EC 3.6.1.-) (BCS1-like protein) | Chaperone necessary for the incorporation of Rieske iron-sulfur protein UQCRFS1 into the mitochondrial respiratory chain complex III (PubMed:11528392, PubMed:9878253). Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (PubMed:18628306). {ECO:0000269|PubMed:11528392, ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:9878253}. |
| Q9Y2H9 | MAST1 | S1258 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2X7 | GIT1 | S700 | psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y4B5 | MTCL1 | S1578 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F1 | FARP1 | S514 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y5T5 | USP16 | S189 | ochoa | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| Q9Y5Y0 | FLVCR1 | S536 | ochoa | Choline/ethanolamine transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (hFLVCR) (Heme transporter FLVCR1) | Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis (PubMed:37100056, PubMed:38693265, PubMed:38778100, PubMed:39306721). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265, PubMed:38778100). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265, PubMed:38778100). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065). {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:22483575, ECO:0000269|PubMed:23187127, ECO:0000269|PubMed:27923065, ECO:0000269|PubMed:37100056, ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0000269|PubMed:39306721}.; FUNCTION: [Isoform 1]: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells (PubMed:37100056, PubMed:38693265). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065). Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity (PubMed:20610401). Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies (PubMed:20610401, PubMed:23187127). Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway (PubMed:20610401). Does not export bilirubin (PubMed:20610401). The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (PubMed:20610401, PubMed:23187127). {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:22483575, ECO:0000269|PubMed:23187127, ECO:0000269|PubMed:27923065, ECO:0000269|PubMed:37100056, ECO:0000269|PubMed:38693265}.; FUNCTION: [Isoform 2]: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. {ECO:0000269|PubMed:23187127}.; FUNCTION: [Isoform 1]: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. {ECO:0000269|PubMed:10400745}. |
| Q9H2C0 | GAN | S52 | Sugiyama | Gigaxonin (Kelch-like protein 16) | Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. {ECO:0000269|PubMed:12147674, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16227972, ECO:0000269|PubMed:16303566}. |
| O60285 | NUAK1 | S325 | Sugiyama | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| Q13435 | SF3B2 | Y645 | Sugiyama | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q15349 | RPS6KA2 | S360 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-444257 | RSK activation | 0.000009 | 5.068 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.000136 | 3.868 |
| R-HSA-199920 | CREB phosphorylation | 0.000158 | 3.803 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000309 | 3.509 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.000966 | 3.015 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.001058 | 2.975 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.001301 | 2.886 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.001511 | 2.821 |
| R-HSA-6807070 | PTEN Regulation | 0.002084 | 2.681 |
| R-HSA-2559583 | Cellular Senescence | 0.002016 | 2.695 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.003062 | 2.514 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.002844 | 2.546 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.002641 | 2.578 |
| R-HSA-198753 | ERK/MAPK targets | 0.003303 | 2.481 |
| R-HSA-437239 | Recycling pathway of L1 | 0.003645 | 2.438 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.004133 | 2.384 |
| R-HSA-162582 | Signal Transduction | 0.004701 | 2.328 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.004855 | 2.314 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.005835 | 2.234 |
| R-HSA-201451 | Signaling by BMP | 0.006378 | 2.195 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.007239 | 2.140 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.007486 | 2.126 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.007615 | 2.118 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.007615 | 2.118 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.007615 | 2.118 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.007615 | 2.118 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.007615 | 2.118 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.009433 | 2.025 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.011178 | 1.952 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.010612 | 1.974 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.013826 | 1.859 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.016022 | 1.795 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.016956 | 1.771 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.017347 | 1.761 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.015462 | 1.811 |
| R-HSA-212436 | Generic Transcription Pathway | 0.017734 | 1.751 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.017856 | 1.748 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.018761 | 1.727 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 0.022231 | 1.653 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 0.022231 | 1.653 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.022267 | 1.652 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.022267 | 1.652 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.021696 | 1.664 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.023746 | 1.624 |
| R-HSA-74160 | Gene expression (Transcription) | 0.023520 | 1.629 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.024747 | 1.606 |
| R-HSA-9843745 | Adipogenesis | 0.026041 | 1.584 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.030650 | 1.514 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 0.033161 | 1.479 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.034825 | 1.458 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.033482 | 1.475 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.037487 | 1.426 |
| R-HSA-5688426 | Deubiquitination | 0.036935 | 1.433 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.035452 | 1.450 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.035452 | 1.450 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.035452 | 1.450 |
| R-HSA-376172 | DSCAM interactions | 0.043970 | 1.357 |
| R-HSA-9839406 | TGFBR3 regulates activin signaling | 0.043970 | 1.357 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.038530 | 1.414 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.044973 | 1.347 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.043970 | 1.357 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.042866 | 1.368 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.042866 | 1.368 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.039589 | 1.402 |
| R-HSA-450294 | MAP kinase activation | 0.043610 | 1.360 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.047466 | 1.324 |
| R-HSA-3214842 | HDMs demethylate histones | 0.048133 | 1.318 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.048658 | 1.313 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.048658 | 1.313 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.051717 | 1.286 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.053587 | 1.271 |
| R-HSA-8939211 | ESR-mediated signaling | 0.071531 | 1.146 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.054659 | 1.262 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.054659 | 1.262 |
| R-HSA-205025 | NADE modulates death signalling | 0.065229 | 1.186 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.067050 | 1.174 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.071932 | 1.143 |
| R-HSA-73894 | DNA Repair | 0.066608 | 1.176 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.069934 | 1.155 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.064130 | 1.193 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.068458 | 1.165 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.071932 | 1.143 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.056664 | 1.247 |
| R-HSA-448424 | Interleukin-17 signaling | 0.058643 | 1.232 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.062275 | 1.206 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.064228 | 1.192 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.064228 | 1.192 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.068484 | 1.164 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.068484 | 1.164 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.057456 | 1.241 |
| R-HSA-373760 | L1CAM interactions | 0.060117 | 1.221 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.073778 | 1.132 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.075681 | 1.121 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.078371 | 1.106 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.081933 | 1.087 |
| R-HSA-4839726 | Chromatin organization | 0.084608 | 1.073 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.086017 | 1.065 |
| R-HSA-597592 | Post-translational protein modification | 0.089645 | 1.047 |
| R-HSA-68877 | Mitotic Prometaphase | 0.092406 | 1.034 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.095203 | 1.021 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.095229 | 1.021 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.106346 | 0.973 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.106346 | 0.973 |
| R-HSA-8875656 | MET receptor recycling | 0.116341 | 0.934 |
| R-HSA-4839744 | Signaling by APC mutants | 0.145664 | 0.837 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.145664 | 0.837 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.145664 | 0.837 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.145664 | 0.837 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.155221 | 0.809 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.164673 | 0.783 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.164673 | 0.783 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.164673 | 0.783 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.164673 | 0.783 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.164673 | 0.783 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.174019 | 0.759 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.192400 | 0.716 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.236594 | 0.626 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.109338 | 0.961 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.245139 | 0.611 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.245139 | 0.611 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.245139 | 0.611 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.245139 | 0.611 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.190346 | 0.720 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.190346 | 0.720 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.202529 | 0.694 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.231260 | 0.636 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.231260 | 0.636 |
| R-HSA-380287 | Centrosome maturation | 0.239523 | 0.621 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.268524 | 0.571 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.209366 | 0.679 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.209366 | 0.679 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.247444 | 0.607 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.101611 | 0.993 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.209366 | 0.679 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.247639 | 0.606 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.227952 | 0.642 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.120518 | 0.919 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 0.126225 | 0.899 |
| R-HSA-3928664 | Ephrin signaling | 0.227952 | 0.642 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.102202 | 0.991 |
| R-HSA-5689603 | UCH proteinases | 0.243659 | 0.613 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.271708 | 0.566 |
| R-HSA-5358508 | Mismatch Repair | 0.227952 | 0.642 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.235389 | 0.628 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.130045 | 0.886 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.096238 | 1.017 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.155221 | 0.809 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.155221 | 0.809 |
| R-HSA-1502540 | Signaling by Activin | 0.192400 | 0.716 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.219212 | 0.659 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.098685 | 1.006 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.098685 | 1.006 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.286461 | 0.543 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.286461 | 0.543 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.227136 | 0.644 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.219212 | 0.659 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.142353 | 0.847 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.106346 | 0.973 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.127714 | 0.894 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.178269 | 0.749 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.276816 | 0.558 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.098685 | 1.006 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.190826 | 0.719 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.120518 | 0.919 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.126225 | 0.899 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.126225 | 0.899 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.155221 | 0.809 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.210375 | 0.677 |
| R-HSA-1181150 | Signaling by NODAL | 0.245139 | 0.611 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.253590 | 0.596 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.276816 | 0.558 |
| R-HSA-9664873 | Pexophagy | 0.135999 | 0.866 |
| R-HSA-69275 | G2/M Transition | 0.200600 | 0.698 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.205206 | 0.688 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.169884 | 0.770 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.233458 | 0.632 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.183261 | 0.737 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.150625 | 0.822 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.186307 | 0.730 |
| R-HSA-5693538 | Homology Directed Repair | 0.186539 | 0.729 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.116341 | 0.934 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.164673 | 0.783 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.192400 | 0.716 |
| R-HSA-429947 | Deadenylation of mRNA | 0.286461 | 0.543 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.235389 | 0.628 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.150211 | 0.823 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.116657 | 0.933 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.232774 | 0.633 |
| R-HSA-199991 | Membrane Trafficking | 0.222187 | 0.653 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.253590 | 0.596 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.155221 | 0.809 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.164673 | 0.783 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.164673 | 0.783 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.164673 | 0.783 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.201438 | 0.696 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.174270 | 0.759 |
| R-HSA-9675135 | Diseases of DNA repair | 0.123982 | 0.907 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.239523 | 0.621 |
| R-HSA-73887 | Death Receptor Signaling | 0.130045 | 0.886 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.192400 | 0.716 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.210375 | 0.677 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.142004 | 0.848 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.200731 | 0.697 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.238258 | 0.623 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.186307 | 0.730 |
| R-HSA-392517 | Rap1 signalling | 0.236594 | 0.626 |
| R-HSA-8854214 | TBC/RABGAPs | 0.112954 | 0.947 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.162368 | 0.789 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.145460 | 0.837 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.270210 | 0.568 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.227136 | 0.644 |
| R-HSA-189451 | Heme biosynthesis | 0.105753 | 0.976 |
| R-HSA-9865881 | Complex III assembly | 0.286461 | 0.543 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.183733 | 0.736 |
| R-HSA-1266738 | Developmental Biology | 0.159777 | 0.796 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.270210 | 0.568 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.116601 | 0.933 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.251942 | 0.599 |
| R-HSA-422475 | Axon guidance | 0.107238 | 0.970 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.122229 | 0.913 |
| R-HSA-68882 | Mitotic Anaphase | 0.274934 | 0.561 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.277415 | 0.557 |
| R-HSA-9675108 | Nervous system development | 0.143659 | 0.843 |
| R-HSA-6806834 | Signaling by MET | 0.260231 | 0.585 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.223018 | 0.652 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.164107 | 0.785 |
| R-HSA-2262752 | Cellular responses to stress | 0.192987 | 0.714 |
| R-HSA-189445 | Metabolism of porphyrins | 0.223018 | 0.652 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.278381 | 0.555 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.127921 | 0.893 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.118531 | 0.926 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.159036 | 0.799 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.159036 | 0.799 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.145796 | 0.836 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.256629 | 0.591 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.218084 | 0.661 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.212173 | 0.673 |
| R-HSA-166520 | Signaling by NTRKs | 0.286883 | 0.542 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.289243 | 0.539 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.289243 | 0.539 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.294452 | 0.531 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.297514 | 0.526 |
| R-HSA-68886 | M Phase | 0.301127 | 0.521 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.302353 | 0.519 |
| R-HSA-525793 | Myogenesis | 0.302353 | 0.519 |
| R-HSA-70635 | Urea cycle | 0.302353 | 0.519 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.302353 | 0.519 |
| R-HSA-1640170 | Cell Cycle | 0.305309 | 0.515 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.309894 | 0.509 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.310167 | 0.508 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.310167 | 0.508 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.310167 | 0.508 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.310167 | 0.508 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.314011 | 0.503 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.317893 | 0.498 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.330423 | 0.481 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.333089 | 0.477 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.333089 | 0.477 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.333089 | 0.477 |
| R-HSA-157118 | Signaling by NOTCH | 0.335250 | 0.475 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.340491 | 0.468 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.340560 | 0.468 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.340560 | 0.468 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.340560 | 0.468 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.342619 | 0.465 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.347947 | 0.458 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.347947 | 0.458 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.347947 | 0.458 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.355253 | 0.449 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.355253 | 0.449 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.355253 | 0.449 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.355253 | 0.449 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.355253 | 0.449 |
| R-HSA-9733709 | Cardiogenesis | 0.355253 | 0.449 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.355253 | 0.449 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.355253 | 0.449 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.362477 | 0.441 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.362477 | 0.441 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.362477 | 0.441 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.362477 | 0.441 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.366286 | 0.436 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.369621 | 0.432 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.369621 | 0.432 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.369621 | 0.432 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.369621 | 0.432 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.370930 | 0.431 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.370930 | 0.431 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.372368 | 0.429 |
| R-HSA-9833110 | RSV-host interactions | 0.374931 | 0.426 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.376685 | 0.424 |
| R-HSA-381042 | PERK regulates gene expression | 0.376685 | 0.424 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.376685 | 0.424 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.376685 | 0.424 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.383670 | 0.416 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.383670 | 0.416 |
| R-HSA-8853659 | RET signaling | 0.383670 | 0.416 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.383670 | 0.416 |
| R-HSA-211000 | Gene Silencing by RNA | 0.386870 | 0.412 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.390577 | 0.408 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.390577 | 0.408 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.390827 | 0.408 |
| R-HSA-416476 | G alpha (q) signalling events | 0.396120 | 0.402 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.397408 | 0.401 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.397408 | 0.401 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.397408 | 0.401 |
| R-HSA-8875878 | MET promotes cell motility | 0.397408 | 0.401 |
| R-HSA-74217 | Purine salvage | 0.397408 | 0.401 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.404162 | 0.393 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.404162 | 0.393 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.404162 | 0.393 |
| R-HSA-69541 | Stabilization of p53 | 0.404162 | 0.393 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.404162 | 0.393 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.406543 | 0.391 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.410841 | 0.386 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.410841 | 0.386 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.410841 | 0.386 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.410841 | 0.386 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.410841 | 0.386 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.410841 | 0.386 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.414328 | 0.383 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.417445 | 0.379 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.417445 | 0.379 |
| R-HSA-5617833 | Cilium Assembly | 0.417561 | 0.379 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.420452 | 0.376 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.422063 | 0.375 |
| R-HSA-167161 | HIV Transcription Initiation | 0.423976 | 0.373 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.423976 | 0.373 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.423976 | 0.373 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.423976 | 0.373 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.429447 | 0.367 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.430434 | 0.366 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.430434 | 0.366 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.436821 | 0.360 |
| R-HSA-373752 | Netrin-1 signaling | 0.443135 | 0.353 |
| R-HSA-5683826 | Surfactant metabolism | 0.443135 | 0.353 |
| R-HSA-69236 | G1 Phase | 0.443135 | 0.353 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.443135 | 0.353 |
| R-HSA-774815 | Nucleosome assembly | 0.449380 | 0.347 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.449380 | 0.347 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.449380 | 0.347 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.449380 | 0.347 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.455510 | 0.342 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.455555 | 0.341 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.455555 | 0.341 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.455555 | 0.341 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.455555 | 0.341 |
| R-HSA-75153 | Apoptotic execution phase | 0.455555 | 0.341 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.455866 | 0.341 |
| R-HSA-72172 | mRNA Splicing | 0.461669 | 0.336 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.467698 | 0.330 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.467698 | 0.330 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.473669 | 0.325 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.473669 | 0.325 |
| R-HSA-114608 | Platelet degranulation | 0.474662 | 0.324 |
| R-HSA-392499 | Metabolism of proteins | 0.474914 | 0.323 |
| R-HSA-72187 | mRNA 3'-end processing | 0.491184 | 0.309 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.491184 | 0.309 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.491184 | 0.309 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.496892 | 0.304 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.496892 | 0.304 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.499866 | 0.301 |
| R-HSA-8951664 | Neddylation | 0.509853 | 0.293 |
| R-HSA-75893 | TNF signaling | 0.513638 | 0.289 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.513638 | 0.289 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.513638 | 0.289 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.513638 | 0.289 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.517391 | 0.286 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.519096 | 0.285 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.519096 | 0.285 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.524493 | 0.280 |
| R-HSA-9664407 | Parasite infection | 0.527711 | 0.278 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.527711 | 0.278 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.527711 | 0.278 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.529830 | 0.276 |
| R-HSA-191859 | snRNP Assembly | 0.529830 | 0.276 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.531117 | 0.275 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.532720 | 0.274 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.535107 | 0.272 |
| R-HSA-379724 | tRNA Aminoacylation | 0.535107 | 0.272 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.537881 | 0.269 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.540325 | 0.267 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.540325 | 0.267 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.540325 | 0.267 |
| R-HSA-8956321 | Nucleotide salvage | 0.540325 | 0.267 |
| R-HSA-9707616 | Heme signaling | 0.545485 | 0.263 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.545485 | 0.263 |
| R-HSA-1268020 | Mitochondrial protein import | 0.545485 | 0.263 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.545485 | 0.263 |
| R-HSA-8848021 | Signaling by PTK6 | 0.550588 | 0.259 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.550588 | 0.259 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.550588 | 0.259 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.555633 | 0.255 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.564261 | 0.249 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.570434 | 0.244 |
| R-HSA-167172 | Transcription of the HIV genome | 0.575258 | 0.240 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.575258 | 0.240 |
| R-HSA-1989781 | PPARA activates gene expression | 0.580195 | 0.236 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.584745 | 0.233 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.584745 | 0.233 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.584745 | 0.233 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.586449 | 0.232 |
| R-HSA-162587 | HIV Life Cycle | 0.586449 | 0.232 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.589409 | 0.230 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.589409 | 0.230 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.594020 | 0.226 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.594020 | 0.226 |
| R-HSA-109581 | Apoptosis | 0.601783 | 0.221 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.603090 | 0.220 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.607549 | 0.216 |
| R-HSA-917937 | Iron uptake and transport | 0.607549 | 0.216 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.611959 | 0.213 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.616319 | 0.210 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.620630 | 0.207 |
| R-HSA-9659379 | Sensory processing of sound | 0.624893 | 0.204 |
| R-HSA-72306 | tRNA processing | 0.628301 | 0.202 |
| R-HSA-8953854 | Metabolism of RNA | 0.628373 | 0.202 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.629108 | 0.201 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.629108 | 0.201 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.633277 | 0.198 |
| R-HSA-977225 | Amyloid fiber formation | 0.633277 | 0.198 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.633277 | 0.198 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.639642 | 0.194 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.641474 | 0.193 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.645504 | 0.190 |
| R-HSA-112316 | Neuronal System | 0.645529 | 0.190 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.653430 | 0.185 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.657326 | 0.182 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.661755 | 0.179 |
| R-HSA-9663891 | Selective autophagy | 0.664989 | 0.177 |
| R-HSA-202424 | Downstream TCR signaling | 0.672481 | 0.172 |
| R-HSA-73884 | Base Excision Repair | 0.672481 | 0.172 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.683408 | 0.165 |
| R-HSA-9609690 | HCMV Early Events | 0.697214 | 0.157 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.704186 | 0.152 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.704186 | 0.152 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.707515 | 0.150 |
| R-HSA-3214847 | HATs acetylate histones | 0.710806 | 0.148 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.713873 | 0.146 |
| R-HSA-70171 | Glycolysis | 0.714061 | 0.146 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.720461 | 0.142 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.720461 | 0.142 |
| R-HSA-1483255 | PI Metabolism | 0.720461 | 0.142 |
| R-HSA-5357801 | Programmed Cell Death | 0.720776 | 0.142 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.732837 | 0.135 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.735845 | 0.133 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.735972 | 0.133 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.738503 | 0.132 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.738820 | 0.131 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.738820 | 0.131 |
| R-HSA-202403 | TCR signaling | 0.747544 | 0.126 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.753199 | 0.123 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.753199 | 0.123 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.753199 | 0.123 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.761445 | 0.118 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.766790 | 0.115 |
| R-HSA-162906 | HIV Infection | 0.767227 | 0.115 |
| R-HSA-70326 | Glucose metabolism | 0.772016 | 0.112 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.772016 | 0.112 |
| R-HSA-68875 | Mitotic Prophase | 0.779637 | 0.108 |
| R-HSA-73886 | Chromosome Maintenance | 0.782121 | 0.107 |
| R-HSA-3371556 | Cellular response to heat stress | 0.782121 | 0.107 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.789406 | 0.103 |
| R-HSA-194138 | Signaling by VEGF | 0.794128 | 0.100 |
| R-HSA-69481 | G2/M Checkpoints | 0.798744 | 0.098 |
| R-HSA-9609646 | HCMV Infection | 0.808498 | 0.092 |
| R-HSA-9909396 | Circadian clock | 0.811985 | 0.090 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.828845 | 0.082 |
| R-HSA-1632852 | Macroautophagy | 0.832155 | 0.080 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.834516 | 0.079 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.835923 | 0.078 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.836141 | 0.078 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.839606 | 0.076 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.843208 | 0.074 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.844527 | 0.073 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.851864 | 0.070 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.853537 | 0.069 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.853819 | 0.069 |
| R-HSA-9658195 | Leishmania infection | 0.853819 | 0.069 |
| R-HSA-9609507 | Protein localization | 0.855191 | 0.068 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.856827 | 0.067 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.858445 | 0.066 |
| R-HSA-9612973 | Autophagy | 0.860044 | 0.065 |
| R-HSA-9610379 | HCMV Late Events | 0.861625 | 0.065 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.872208 | 0.059 |
| R-HSA-5619102 | SLC transporter disorders | 0.876494 | 0.057 |
| R-HSA-388396 | GPCR downstream signalling | 0.886509 | 0.052 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.888511 | 0.051 |
| R-HSA-9679506 | SARS-CoV Infections | 0.890740 | 0.050 |
| R-HSA-611105 | Respiratory electron transport | 0.892252 | 0.050 |
| R-HSA-168255 | Influenza Infection | 0.893472 | 0.049 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.898213 | 0.047 |
| R-HSA-168249 | Innate Immune System | 0.899919 | 0.046 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.901630 | 0.045 |
| R-HSA-372790 | Signaling by GPCR | 0.933171 | 0.030 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.939749 | 0.027 |
| R-HSA-72312 | rRNA processing | 0.942439 | 0.026 |
| R-HSA-15869 | Metabolism of nucleotides | 0.945009 | 0.025 |
| R-HSA-9824446 | Viral Infection Pathways | 0.949395 | 0.023 |
| R-HSA-109582 | Hemostasis | 0.950784 | 0.022 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.951504 | 0.022 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.970012 | 0.013 |
| R-HSA-1483257 | Phospholipid metabolism | 0.972005 | 0.012 |
| R-HSA-6798695 | Neutrophil degranulation | 0.972031 | 0.012 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.972324 | 0.012 |
| R-HSA-195721 | Signaling by WNT | 0.972952 | 0.012 |
| R-HSA-1643685 | Disease | 0.972982 | 0.012 |
| R-HSA-449147 | Signaling by Interleukins | 0.977616 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.983491 | 0.007 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.984592 | 0.007 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.984942 | 0.007 |
| R-HSA-913531 | Interferon Signaling | 0.989938 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.991137 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992372 | 0.003 |
| R-HSA-1280218 | Adaptive Immune System | 0.993714 | 0.003 |
| R-HSA-72766 | Translation | 0.994084 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.994435 | 0.002 |
| R-HSA-5663205 | Infectious disease | 0.994492 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995621 | 0.002 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.998606 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999079 | 0.000 |
| R-HSA-168256 | Immune System | 0.999146 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999991 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999996 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.815 | 0.712 | 1 | 0.839 |
CDK17 |
0.811 | 0.711 | 1 | 0.867 |
CDK16 |
0.807 | 0.689 | 1 | 0.855 |
CDK19 |
0.800 | 0.647 | 1 | 0.821 |
HIPK2 |
0.796 | 0.583 | 1 | 0.820 |
P38G |
0.796 | 0.675 | 1 | 0.875 |
CDK7 |
0.795 | 0.672 | 1 | 0.789 |
ERK1 |
0.795 | 0.674 | 1 | 0.821 |
CDK14 |
0.794 | 0.673 | 1 | 0.802 |
CDK3 |
0.793 | 0.601 | 1 | 0.860 |
CDK8 |
0.793 | 0.643 | 1 | 0.782 |
JNK2 |
0.790 | 0.677 | 1 | 0.834 |
KIS |
0.790 | 0.561 | 1 | 0.761 |
CDK5 |
0.788 | 0.643 | 1 | 0.762 |
P38D |
0.787 | 0.652 | 1 | 0.877 |
P38B |
0.787 | 0.665 | 1 | 0.801 |
CDK1 |
0.787 | 0.645 | 1 | 0.811 |
CDK13 |
0.786 | 0.646 | 1 | 0.813 |
CDK12 |
0.785 | 0.643 | 1 | 0.833 |
DYRK2 |
0.784 | 0.580 | 1 | 0.730 |
CDK10 |
0.781 | 0.586 | 1 | 0.818 |
HIPK1 |
0.780 | 0.544 | 1 | 0.714 |
ERK2 |
0.780 | 0.671 | 1 | 0.768 |
JNK3 |
0.780 | 0.666 | 1 | 0.803 |
P38A |
0.779 | 0.640 | 1 | 0.734 |
DYRK4 |
0.778 | 0.582 | 1 | 0.827 |
DYRK1B |
0.776 | 0.567 | 1 | 0.786 |
CDK9 |
0.776 | 0.620 | 1 | 0.806 |
CDK4 |
0.773 | 0.630 | 1 | 0.843 |
MAK |
0.773 | 0.462 | -2 | 0.799 |
HIPK3 |
0.772 | 0.520 | 1 | 0.688 |
DYRK1A |
0.772 | 0.471 | 1 | 0.690 |
CDK6 |
0.772 | 0.613 | 1 | 0.822 |
NLK |
0.769 | 0.602 | 1 | 0.518 |
HIPK4 |
0.766 | 0.369 | 1 | 0.511 |
CLK3 |
0.764 | 0.395 | 1 | 0.474 |
ERK5 |
0.764 | 0.412 | 1 | 0.434 |
SRPK1 |
0.761 | 0.240 | -3 | 0.289 |
JNK1 |
0.761 | 0.599 | 1 | 0.833 |
DYRK3 |
0.760 | 0.414 | 1 | 0.675 |
CDK2 |
0.753 | 0.468 | 1 | 0.685 |
CLK1 |
0.752 | 0.289 | -3 | 0.255 |
MOK |
0.752 | 0.386 | 1 | 0.603 |
SRPK2 |
0.752 | 0.180 | -3 | 0.245 |
ICK |
0.749 | 0.301 | -3 | 0.348 |
CDKL5 |
0.749 | 0.135 | -3 | 0.312 |
CLK4 |
0.744 | 0.259 | -3 | 0.262 |
CDKL1 |
0.741 | 0.107 | -3 | 0.305 |
CLK2 |
0.741 | 0.271 | -3 | 0.274 |
MTOR |
0.740 | 0.176 | 1 | 0.308 |
PRKD1 |
0.739 | 0.066 | -3 | 0.384 |
SRPK3 |
0.739 | 0.155 | -3 | 0.256 |
PRP4 |
0.737 | 0.318 | -3 | 0.267 |
COT |
0.736 | -0.001 | 2 | 0.809 |
PRKD2 |
0.735 | 0.024 | -3 | 0.332 |
NDR2 |
0.729 | 0.041 | -3 | 0.410 |
TBK1 |
0.727 | -0.077 | 1 | 0.109 |
PKN3 |
0.726 | -0.021 | -3 | 0.324 |
NUAK2 |
0.726 | 0.009 | -3 | 0.323 |
WNK1 |
0.725 | -0.025 | -2 | 0.877 |
MOS |
0.725 | 0.003 | 1 | 0.175 |
CDC7 |
0.724 | -0.078 | 1 | 0.125 |
PIM3 |
0.724 | -0.016 | -3 | 0.362 |
NDR1 |
0.724 | -0.018 | -3 | 0.348 |
ERK7 |
0.724 | 0.207 | 2 | 0.503 |
P90RSK |
0.723 | -0.014 | -3 | 0.309 |
PRKD3 |
0.723 | -0.011 | -3 | 0.272 |
MAPKAPK3 |
0.723 | -0.031 | -3 | 0.321 |
NEK6 |
0.723 | 0.011 | -2 | 0.810 |
MPSK1 |
0.722 | 0.194 | 1 | 0.212 |
PRPK |
0.722 | -0.085 | -1 | 0.857 |
RIPK3 |
0.722 | -0.024 | 3 | 0.821 |
SKMLCK |
0.721 | 0.022 | -2 | 0.852 |
RSK2 |
0.721 | -0.020 | -3 | 0.310 |
IKKE |
0.721 | -0.093 | 1 | 0.107 |
IRE1 |
0.721 | -0.012 | 1 | 0.126 |
MAPKAPK2 |
0.720 | -0.021 | -3 | 0.315 |
CAMK1B |
0.720 | -0.052 | -3 | 0.299 |
MST4 |
0.720 | -0.041 | 2 | 0.777 |
PKCD |
0.720 | 0.001 | 2 | 0.733 |
TSSK1 |
0.720 | 0.027 | -3 | 0.366 |
PHKG1 |
0.719 | -0.027 | -3 | 0.322 |
PKN2 |
0.719 | -0.052 | -3 | 0.296 |
MNK2 |
0.719 | 0.029 | -2 | 0.784 |
PIM1 |
0.719 | -0.008 | -3 | 0.300 |
ATR |
0.719 | -0.049 | 1 | 0.171 |
ULK2 |
0.718 | -0.145 | 2 | 0.759 |
LATS2 |
0.718 | 0.002 | -5 | 0.742 |
RSK3 |
0.718 | -0.038 | -3 | 0.294 |
RAF1 |
0.718 | -0.149 | 1 | 0.124 |
CHAK2 |
0.718 | 0.003 | -1 | 0.875 |
AMPKA1 |
0.718 | -0.029 | -3 | 0.339 |
PDHK4 |
0.718 | -0.120 | 1 | 0.188 |
AURC |
0.717 | 0.026 | -2 | 0.655 |
NIK |
0.717 | -0.042 | -3 | 0.315 |
IKKB |
0.717 | -0.112 | -2 | 0.748 |
CAMLCK |
0.716 | -0.001 | -2 | 0.845 |
IRE2 |
0.716 | 0.004 | 2 | 0.746 |
NUAK1 |
0.716 | -0.030 | -3 | 0.294 |
GCN2 |
0.716 | -0.188 | 2 | 0.762 |
MELK |
0.715 | -0.031 | -3 | 0.303 |
PDHK1 |
0.715 | -0.124 | 1 | 0.168 |
AMPKA2 |
0.715 | -0.024 | -3 | 0.330 |
NEK7 |
0.715 | -0.092 | -3 | 0.349 |
BMPR2 |
0.715 | -0.135 | -2 | 0.863 |
MLK3 |
0.714 | 0.015 | 2 | 0.683 |
PKCA |
0.714 | 0.021 | 2 | 0.672 |
MNK1 |
0.714 | 0.028 | -2 | 0.786 |
TSSK2 |
0.714 | 0.002 | -5 | 0.852 |
BUB1 |
0.714 | 0.221 | -5 | 0.838 |
NIM1 |
0.713 | -0.038 | 3 | 0.792 |
MLK2 |
0.713 | -0.012 | 2 | 0.772 |
DAPK2 |
0.713 | -0.020 | -3 | 0.324 |
WNK3 |
0.713 | -0.116 | 1 | 0.126 |
DSTYK |
0.712 | -0.166 | 2 | 0.801 |
MLK1 |
0.712 | -0.091 | 2 | 0.756 |
TGFBR2 |
0.712 | -0.065 | -2 | 0.758 |
MARK4 |
0.712 | -0.040 | 4 | 0.798 |
AKT2 |
0.712 | -0.009 | -3 | 0.245 |
SGK3 |
0.712 | -0.008 | -3 | 0.296 |
HUNK |
0.711 | -0.101 | 2 | 0.753 |
LATS1 |
0.711 | 0.113 | -3 | 0.446 |
PKACG |
0.711 | -0.030 | -2 | 0.722 |
ULK1 |
0.711 | -0.135 | -3 | 0.293 |
P70S6KB |
0.711 | -0.045 | -3 | 0.282 |
PKCB |
0.711 | -0.019 | 2 | 0.685 |
GRK1 |
0.710 | 0.033 | -2 | 0.781 |
PKCG |
0.710 | -0.010 | 2 | 0.675 |
PINK1 |
0.710 | 0.102 | 1 | 0.346 |
PAK6 |
0.709 | -0.019 | -2 | 0.719 |
IKKA |
0.709 | -0.017 | -2 | 0.733 |
RSK4 |
0.708 | -0.006 | -3 | 0.335 |
PAK3 |
0.708 | -0.045 | -2 | 0.787 |
NEK9 |
0.708 | -0.124 | 2 | 0.785 |
BCKDK |
0.708 | -0.113 | -1 | 0.807 |
PKG2 |
0.708 | 0.009 | -2 | 0.661 |
CAMK2D |
0.708 | -0.077 | -3 | 0.325 |
AKT1 |
0.707 | -0.008 | -3 | 0.267 |
PKACB |
0.706 | -0.008 | -2 | 0.658 |
MSK2 |
0.706 | -0.054 | -3 | 0.293 |
RIPK1 |
0.706 | -0.124 | 1 | 0.113 |
PAK1 |
0.706 | -0.038 | -2 | 0.786 |
PKCZ |
0.706 | -0.022 | 2 | 0.731 |
CAMK4 |
0.706 | -0.088 | -3 | 0.296 |
PIM2 |
0.706 | -0.016 | -3 | 0.267 |
CAMK2G |
0.705 | -0.109 | 2 | 0.752 |
MASTL |
0.705 | -0.114 | -2 | 0.808 |
QIK |
0.705 | -0.070 | -3 | 0.308 |
NEK2 |
0.705 | -0.078 | 2 | 0.765 |
VRK2 |
0.705 | 0.137 | 1 | 0.225 |
ANKRD3 |
0.704 | -0.078 | 1 | 0.139 |
PHKG2 |
0.704 | -0.067 | -3 | 0.261 |
QSK |
0.703 | -0.038 | 4 | 0.788 |
DCAMKL1 |
0.703 | -0.031 | -3 | 0.312 |
PKCH |
0.703 | -0.044 | 2 | 0.678 |
CHK1 |
0.703 | 0.010 | -3 | 0.370 |
AURB |
0.702 | -0.007 | -2 | 0.649 |
PLK4 |
0.702 | 0.003 | 2 | 0.637 |
IRAK4 |
0.702 | -0.026 | 1 | 0.109 |
DNAPK |
0.702 | -0.037 | 1 | 0.169 |
CK1E |
0.701 | -0.058 | -3 | 0.180 |
SIK |
0.701 | -0.071 | -3 | 0.271 |
PKR |
0.700 | -0.066 | 1 | 0.145 |
GRK5 |
0.700 | -0.163 | -3 | 0.300 |
SSTK |
0.700 | 0.007 | 4 | 0.795 |
AKT3 |
0.700 | -0.007 | -3 | 0.246 |
SMG1 |
0.700 | -0.064 | 1 | 0.160 |
CHAK1 |
0.700 | -0.084 | 2 | 0.723 |
PKN1 |
0.700 | -0.036 | -3 | 0.247 |
ATM |
0.700 | -0.077 | 1 | 0.136 |
MLK4 |
0.699 | -0.057 | 2 | 0.685 |
CAMK1G |
0.699 | -0.066 | -3 | 0.251 |
MAPKAPK5 |
0.699 | -0.098 | -3 | 0.250 |
PRKX |
0.699 | -0.008 | -3 | 0.289 |
PAK2 |
0.699 | -0.047 | -2 | 0.770 |
PKCT |
0.699 | -0.043 | 2 | 0.690 |
MYLK4 |
0.699 | -0.051 | -2 | 0.767 |
BMPR1B |
0.699 | -0.059 | 1 | 0.095 |
DLK |
0.698 | -0.141 | 1 | 0.124 |
BRSK2 |
0.698 | -0.092 | -3 | 0.298 |
WNK4 |
0.698 | -0.055 | -2 | 0.862 |
MSK1 |
0.697 | -0.046 | -3 | 0.286 |
SBK |
0.697 | 0.047 | -3 | 0.202 |
ALK4 |
0.697 | -0.053 | -2 | 0.811 |
CAMK2A |
0.696 | -0.030 | 2 | 0.721 |
BRSK1 |
0.696 | -0.081 | -3 | 0.297 |
TTBK2 |
0.696 | -0.166 | 2 | 0.664 |
CK1D |
0.695 | -0.047 | -3 | 0.157 |
SNRK |
0.695 | -0.119 | 2 | 0.684 |
GRK7 |
0.694 | -0.002 | 1 | 0.145 |
DCAMKL2 |
0.694 | -0.047 | -3 | 0.301 |
PKCI |
0.694 | -0.033 | 2 | 0.699 |
NEK5 |
0.694 | -0.029 | 1 | 0.125 |
P70S6K |
0.693 | -0.059 | -3 | 0.240 |
CAMK2B |
0.693 | -0.056 | 2 | 0.713 |
YSK4 |
0.693 | -0.139 | 1 | 0.109 |
MEKK1 |
0.693 | -0.077 | 1 | 0.134 |
PKACA |
0.693 | -0.024 | -2 | 0.615 |
MARK3 |
0.693 | -0.047 | 4 | 0.736 |
ZAK |
0.693 | -0.070 | 1 | 0.108 |
SGK1 |
0.693 | -0.005 | -3 | 0.226 |
CHK2 |
0.692 | -0.042 | -3 | 0.211 |
MST3 |
0.692 | -0.041 | 2 | 0.761 |
TGFBR1 |
0.692 | -0.062 | -2 | 0.787 |
PKCE |
0.692 | -0.011 | 2 | 0.661 |
CAMK1D |
0.692 | -0.052 | -3 | 0.248 |
MEK5 |
0.691 | -0.084 | 2 | 0.780 |
CAMK1A |
0.691 | -0.033 | -3 | 0.228 |
SMMLCK |
0.691 | -0.036 | -3 | 0.284 |
GRK6 |
0.690 | -0.174 | 1 | 0.110 |
MARK2 |
0.690 | -0.059 | 4 | 0.695 |
PAK5 |
0.690 | -0.043 | -2 | 0.648 |
GSK3A |
0.690 | 0.132 | 4 | 0.315 |
MEKK2 |
0.689 | -0.076 | 2 | 0.767 |
CK1A2 |
0.689 | -0.069 | -3 | 0.152 |
MEK1 |
0.689 | -0.168 | 2 | 0.788 |
HRI |
0.688 | -0.135 | -2 | 0.815 |
LKB1 |
0.688 | -0.007 | -3 | 0.335 |
FAM20C |
0.688 | -0.035 | 2 | 0.559 |
CK1G1 |
0.688 | -0.100 | -3 | 0.163 |
PLK1 |
0.687 | -0.131 | -2 | 0.750 |
GRK4 |
0.687 | -0.166 | -2 | 0.789 |
TAO3 |
0.686 | -0.034 | 1 | 0.153 |
MAP3K15 |
0.686 | 0.009 | 1 | 0.126 |
AURA |
0.686 | -0.035 | -2 | 0.625 |
PAK4 |
0.686 | -0.031 | -2 | 0.660 |
TLK2 |
0.685 | -0.099 | 1 | 0.111 |
PERK |
0.685 | -0.145 | -2 | 0.812 |
HASPIN |
0.685 | 0.055 | -1 | 0.777 |
DRAK1 |
0.685 | -0.125 | 1 | 0.085 |
MARK1 |
0.685 | -0.086 | 4 | 0.762 |
MEKK6 |
0.684 | -0.060 | 1 | 0.132 |
ACVR2A |
0.684 | -0.111 | -2 | 0.754 |
NEK4 |
0.684 | -0.078 | 1 | 0.117 |
PBK |
0.683 | -0.008 | 1 | 0.187 |
MEKK3 |
0.683 | -0.155 | 1 | 0.126 |
PDK1 |
0.683 | -0.044 | 1 | 0.161 |
BRAF |
0.683 | -0.123 | -4 | 0.761 |
NEK11 |
0.683 | -0.093 | 1 | 0.145 |
TNIK |
0.682 | -0.007 | 3 | 0.844 |
ALK2 |
0.682 | -0.090 | -2 | 0.791 |
HGK |
0.682 | -0.036 | 3 | 0.848 |
PASK |
0.682 | -0.004 | -3 | 0.401 |
ACVR2B |
0.682 | -0.119 | -2 | 0.762 |
DAPK3 |
0.682 | -0.032 | -3 | 0.298 |
MRCKB |
0.682 | -0.034 | -3 | 0.250 |
AAK1 |
0.681 | 0.071 | 1 | 0.218 |
NEK1 |
0.681 | -0.032 | 1 | 0.110 |
TAO2 |
0.681 | -0.064 | 2 | 0.786 |
TLK1 |
0.680 | -0.130 | -2 | 0.787 |
GRK2 |
0.680 | -0.103 | -2 | 0.686 |
ROCK2 |
0.679 | -0.017 | -3 | 0.306 |
IRAK1 |
0.679 | -0.164 | -1 | 0.779 |
CAMKK2 |
0.678 | -0.039 | -2 | 0.783 |
BIKE |
0.678 | 0.029 | 1 | 0.202 |
MRCKA |
0.678 | -0.034 | -3 | 0.268 |
LOK |
0.677 | -0.057 | -2 | 0.767 |
NEK8 |
0.677 | -0.122 | 2 | 0.772 |
CRIK |
0.677 | -0.002 | -3 | 0.299 |
BMPR1A |
0.677 | -0.086 | 1 | 0.084 |
GCK |
0.677 | -0.046 | 1 | 0.138 |
GAK |
0.677 | -0.058 | 1 | 0.196 |
KHS1 |
0.676 | -0.034 | 1 | 0.135 |
MINK |
0.676 | -0.086 | 1 | 0.116 |
CAMKK1 |
0.676 | -0.124 | -2 | 0.776 |
PLK3 |
0.676 | -0.156 | 2 | 0.714 |
DMPK1 |
0.676 | -0.005 | -3 | 0.264 |
TTBK1 |
0.675 | -0.143 | 2 | 0.590 |
LRRK2 |
0.675 | -0.013 | 2 | 0.792 |
KHS2 |
0.674 | -0.017 | 1 | 0.147 |
PKG1 |
0.674 | -0.049 | -2 | 0.585 |
NEK3 |
0.673 | -0.096 | 1 | 0.137 |
DAPK1 |
0.673 | -0.047 | -3 | 0.279 |
HPK1 |
0.673 | -0.087 | 1 | 0.140 |
YSK1 |
0.672 | -0.074 | 2 | 0.755 |
EEF2K |
0.671 | -0.059 | 3 | 0.808 |
MST2 |
0.670 | -0.101 | 1 | 0.120 |
GSK3B |
0.670 | -0.001 | 4 | 0.305 |
RIPK2 |
0.668 | -0.157 | 1 | 0.096 |
ROCK1 |
0.668 | -0.038 | -3 | 0.256 |
VRK1 |
0.667 | -0.083 | 2 | 0.802 |
PDHK3_TYR |
0.666 | 0.236 | 4 | 0.844 |
SLK |
0.665 | -0.074 | -2 | 0.704 |
LIMK2_TYR |
0.665 | 0.152 | -3 | 0.361 |
MST1 |
0.664 | -0.109 | 1 | 0.112 |
GRK3 |
0.664 | -0.113 | -2 | 0.636 |
TAK1 |
0.664 | -0.164 | 1 | 0.110 |
STK33 |
0.663 | -0.107 | 2 | 0.569 |
ASK1 |
0.662 | -0.029 | 1 | 0.124 |
MYO3B |
0.661 | -0.042 | 2 | 0.775 |
MEK2 |
0.661 | -0.161 | 2 | 0.779 |
TESK1_TYR |
0.661 | 0.100 | 3 | 0.851 |
TAO1 |
0.660 | -0.056 | 1 | 0.126 |
TTK |
0.660 | -0.037 | -2 | 0.769 |
PKMYT1_TYR |
0.659 | 0.110 | 3 | 0.840 |
OSR1 |
0.658 | -0.044 | 2 | 0.752 |
MYO3A |
0.657 | -0.045 | 1 | 0.134 |
CK2A2 |
0.657 | -0.092 | 1 | 0.082 |
JAK2 |
0.655 | 0.037 | 1 | 0.154 |
PDHK4_TYR |
0.655 | 0.113 | 2 | 0.816 |
ROS1 |
0.653 | 0.015 | 3 | 0.814 |
JAK1 |
0.652 | 0.033 | 1 | 0.127 |
RET |
0.652 | -0.046 | 1 | 0.145 |
TYK2 |
0.652 | -0.049 | 1 | 0.135 |
MST1R |
0.652 | -0.001 | 3 | 0.845 |
CSF1R |
0.652 | 0.013 | 3 | 0.840 |
CK1A |
0.652 | -0.090 | -3 | 0.117 |
TNK1 |
0.651 | 0.046 | 3 | 0.805 |
LIMK1_TYR |
0.651 | 0.012 | 2 | 0.808 |
PLK2 |
0.651 | -0.121 | -3 | 0.252 |
MAP2K7_TYR |
0.650 | -0.079 | 2 | 0.806 |
MAP2K4_TYR |
0.650 | -0.066 | -1 | 0.879 |
CK2A1 |
0.648 | -0.098 | 1 | 0.073 |
TNNI3K_TYR |
0.648 | 0.014 | 1 | 0.162 |
PINK1_TYR |
0.648 | -0.112 | 1 | 0.176 |
TYRO3 |
0.648 | -0.025 | 3 | 0.826 |
JAK3 |
0.646 | -0.033 | 1 | 0.131 |
EPHA6 |
0.646 | -0.051 | -1 | 0.855 |
TNK2 |
0.646 | 0.015 | 3 | 0.829 |
MAP2K6_TYR |
0.646 | -0.077 | -1 | 0.885 |
KDR |
0.646 | 0.019 | 3 | 0.824 |
ABL2 |
0.645 | -0.040 | -1 | 0.809 |
PDHK1_TYR |
0.644 | -0.075 | -1 | 0.888 |
BMPR2_TYR |
0.644 | -0.051 | -1 | 0.873 |
TEK |
0.643 | 0.041 | 3 | 0.778 |
NEK10_TYR |
0.642 | -0.081 | 1 | 0.133 |
FGFR2 |
0.642 | 0.003 | 3 | 0.822 |
FGFR1 |
0.642 | 0.017 | 3 | 0.811 |
ABL1 |
0.641 | -0.059 | -1 | 0.801 |
YANK3 |
0.641 | -0.072 | 2 | 0.366 |
LCK |
0.641 | -0.039 | -1 | 0.812 |
YES1 |
0.641 | -0.054 | -1 | 0.833 |
EPHB4 |
0.641 | -0.056 | -1 | 0.825 |
STLK3 |
0.641 | -0.121 | 1 | 0.096 |
DDR1 |
0.640 | -0.071 | 4 | 0.784 |
BLK |
0.640 | -0.030 | -1 | 0.818 |
HCK |
0.640 | -0.061 | -1 | 0.813 |
ALPHAK3 |
0.639 | -0.094 | -1 | 0.775 |
PDGFRB |
0.638 | -0.079 | 3 | 0.843 |
FLT3 |
0.637 | -0.106 | 3 | 0.827 |
KIT |
0.637 | -0.059 | 3 | 0.832 |
PDGFRA |
0.636 | -0.071 | 3 | 0.840 |
INSRR |
0.636 | -0.080 | 3 | 0.794 |
FGR |
0.636 | -0.123 | 1 | 0.119 |
AXL |
0.635 | -0.034 | 3 | 0.832 |
TXK |
0.635 | -0.069 | 1 | 0.095 |
DDR2 |
0.635 | 0.021 | 3 | 0.794 |
CK1G3 |
0.633 | -0.092 | -3 | 0.095 |
MERTK |
0.633 | -0.041 | 3 | 0.816 |
MET |
0.633 | -0.046 | 3 | 0.831 |
FER |
0.633 | -0.131 | 1 | 0.120 |
FGFR3 |
0.632 | -0.014 | 3 | 0.808 |
WEE1_TYR |
0.631 | -0.048 | -1 | 0.741 |
ALK |
0.631 | -0.064 | 3 | 0.764 |
ITK |
0.630 | -0.090 | -1 | 0.788 |
EPHB1 |
0.630 | -0.094 | 1 | 0.092 |
EPHB3 |
0.628 | -0.098 | -1 | 0.805 |
FRK |
0.628 | -0.072 | -1 | 0.819 |
EPHA1 |
0.628 | -0.067 | 3 | 0.823 |
EPHA4 |
0.627 | -0.086 | 2 | 0.699 |
SRMS |
0.626 | -0.139 | 1 | 0.090 |
LTK |
0.625 | -0.092 | 3 | 0.776 |
FYN |
0.625 | -0.068 | -1 | 0.784 |
BTK |
0.625 | -0.141 | -1 | 0.758 |
INSR |
0.625 | -0.086 | 3 | 0.777 |
FLT4 |
0.625 | -0.082 | 3 | 0.794 |
TEC |
0.624 | -0.098 | -1 | 0.716 |
LYN |
0.624 | -0.068 | 3 | 0.766 |
EPHA7 |
0.624 | -0.070 | 2 | 0.712 |
ERBB2 |
0.624 | -0.123 | 1 | 0.112 |
EPHB2 |
0.623 | -0.121 | -1 | 0.800 |
BMX |
0.623 | -0.084 | -1 | 0.703 |
NTRK2 |
0.623 | -0.121 | 3 | 0.810 |
FLT1 |
0.622 | -0.110 | -1 | 0.836 |
NTRK1 |
0.621 | -0.134 | -1 | 0.816 |
NTRK3 |
0.620 | -0.086 | -1 | 0.763 |
MATK |
0.620 | -0.071 | -1 | 0.737 |
EGFR |
0.619 | -0.082 | 1 | 0.082 |
EPHA3 |
0.617 | -0.100 | 2 | 0.688 |
MUSK |
0.617 | -0.089 | 1 | 0.076 |
PTK2B |
0.615 | -0.084 | -1 | 0.756 |
SRC |
0.615 | -0.104 | -1 | 0.782 |
PTK6 |
0.614 | -0.159 | -1 | 0.718 |
FGFR4 |
0.613 | -0.081 | -1 | 0.762 |
EPHA8 |
0.613 | -0.091 | -1 | 0.784 |
YANK2 |
0.611 | -0.086 | 2 | 0.375 |
EPHA5 |
0.609 | -0.108 | 2 | 0.695 |
CSK |
0.609 | -0.121 | 2 | 0.719 |
ERBB4 |
0.608 | -0.071 | 1 | 0.082 |
IGF1R |
0.607 | -0.089 | 3 | 0.711 |
PTK2 |
0.606 | -0.072 | -1 | 0.798 |
EPHA2 |
0.604 | -0.084 | -1 | 0.763 |
SYK |
0.603 | -0.097 | -1 | 0.770 |
CK1G2 |
0.600 | -0.101 | -3 | 0.129 |
FES |
0.596 | -0.098 | -1 | 0.679 |
ZAP70 |
0.595 | -0.067 | -1 | 0.696 |