Motif 419 (n=136)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NE02 | BTBD17 | S42 | ochoa | BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) | None |
| A6NKT7 | RGPD3 | S392 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| F8WAN1 | SPECC1L-ADORA2A | S48 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| H0YHG0 | None | S451 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| K7EQG2 | None | S85 | ochoa | Uncharacterized protein | None |
| L7N2F9 | None | S75 | ochoa | V-SNARE coiled-coil homology domain-containing protein | None |
| O00273 | DFFA | S228 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O14545 | TRAFD1 | S272 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14874 | BCKDK | S339 | ochoa | Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4) | Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:24449431, PubMed:29779826, PubMed:37558654). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (PubMed:29779826, PubMed:37558654). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxxE/D canonical motif (PubMed:29779826). {ECO:0000269|PubMed:24449431, ECO:0000269|PubMed:29779826, ECO:0000269|PubMed:37558654}. |
| O14936 | CASK | S313 | ochoa | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O15231 | ZNF185 | S203 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O43639 | NCK2 | S270 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O43683 | BUB1 | S436 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43707 | ACTN4 | S262 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60343 | TBC1D4 | S102 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O75122 | CLASP2 | S364 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75496 | GMNN | S49 | ochoa | Geminin | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}. |
| O95758 | PTBP3 | S159 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| P00519 | ABL1 | S59 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P08195 | SLC3A2 | S134 | ochoa | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P08865 | RPSA | S75 | ochoa | Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}. |
| P09104 | ENO2 | S40 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
| P10275 | AR | S302 | ochoa | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P11171 | EPB41 | S555 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12111 | COL6A3 | S162 | ochoa | Collagen alpha-3(VI) chain | Collagen VI acts as a cell-binding protein. |
| P12268 | IMPDH2 | S425 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P12814 | ACTN1 | S243 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13929 | ENO3 | S40 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P15036 | ETS2 | S88 | ochoa | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P18206 | VCL | S574 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P21333 | FLNA | S2558 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21359 | NF1 | S2180 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P22736 | NR4A1 | S52 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P25054 | APC | S245 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25054 | APC | S2125 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25705 | ATP5F1A | S413 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P29274 | ADORA2A | S329 | ochoa | Adenosine receptor A2a | Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| P35221 | CTNNA1 | S264 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35367 | HRH1 | S317 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P40926 | MDH2 | S250 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P43243 | MATR3 | S35 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P43403 | ZAP70 | S491 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P46013 | MKI67 | S2941 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48048 | KCNJ1 | S183 | psp | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}. |
| P48681 | NES | S51 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48729 | CSNK1A1 | S312 | ochoa | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. |
| P49792 | RANBP2 | S391 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51582 | P2RY4 | S334 | psp | P2Y purinoceptor 4 (P2Y4) (P2P) (Uridine nucleotide receptor) (UNR) | Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. |
| P53618 | COPB1 | S529 | ochoa | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}. |
| P60709 | ACTB | S233 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61073 | CXCR4 | S319 | ochoa | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250|UniProtKB:P70658, ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10452968, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:18799424, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:24912431, ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609). {ECO:0000269|PubMed:10074122, ECO:0000269|PubMed:10756055, ECO:0000269|PubMed:8849450, ECO:0000269|PubMed:8929542, ECO:0000269|PubMed:9427609}. |
| P62736 | ACTA2 | S235 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63027 | VAMP2 | S75 | ochoa | Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}. |
| P63261 | ACTG1 | S233 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S234 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S235 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S235 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P82979 | SARNP | S138 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| Q00536 | CDK16 | S65 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q03468 | ERCC6 | S1380 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q09666 | AHNAK | S242 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S1353 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13224 | GRIN2B | S1415 | psp | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q13263 | TRIM28 | S43 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13459 | MYO9B | S1325 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q14761 | PTPRCAP | S172 | ochoa|psp | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
| Q14847 | LASP1 | S194 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14974 | KPNB1 | S683 | ochoa | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}. |
| Q15424 | SAFB | S20 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15836 | VAMP3 | S58 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q2NKQ1 | SGSM1 | S684 | ochoa | Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) | Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as a GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. {ECO:0000269|PubMed:22637480}. |
| Q32MZ4 | LRRFIP1 | S766 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q562R1 | ACTBL2 | S234 | ochoa | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
| Q5FWE3 | PRRT3 | S902 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JR12 | PPM1J | S66 | ochoa | Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) | None |
| Q5SRE5 | NUP188 | S1531 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q641Q2 | WASHC2A | S990 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68DK7 | MSL1 | S126 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q69YQ0 | SPECC1L | S48 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6IAA8 | LAMTOR1 | S55 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6PJ61 | FBXO46 | S189 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6S8J3 | POTEE | S933 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6ZVL6 | KIAA1549L | S1581 | ochoa | UPF0606 protein KIAA1549L | None |
| Q7RTP6 | MICAL3 | S863 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z3J3 | RGPD4 | S392 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86V48 | LUZP1 | S569 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8IY67 | RAVER1 | S511 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8NEY1 | NAV1 | S194 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q92610 | ZNF592 | S458 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92896 | GLG1 | S509 | ochoa | Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) | Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). {ECO:0000269|PubMed:8985126}. |
| Q96PY6 | NEK1 | S418 | psp | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96QE2 | SLC2A13 | S47 | ochoa | Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) | H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}. |
| Q96SI9 | STRBP | S565 | ochoa | Spermatid perinuclear RNA-binding protein | Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}. |
| Q96T58 | SPEN | S1797 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96TC7 | RMDN3 | S232 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q9BQ89 | FAM110A | S228 | ochoa | Protein FAM110A | None |
| Q9BRJ6 | C7orf50 | S36 | ochoa | Protein cholesin | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}. |
| Q9BSV6 | TSEN34 | S135 | ochoa | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q9BXS6 | NUSAP1 | S305 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BY11 | PACSIN1 | S337 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
| Q9BY77 | POLDIP3 | S216 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9H765 | ASB8 | S31 | psp | Ankyrin repeat and SOCS box protein 8 (ASB-8) | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation (PubMed:32298923). {ECO:0000269|PubMed:32298923}. |
| Q9NQW6 | ANLN | S275 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR48 | ASH1L | S1742 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NUQ6 | SPATS2L | S362 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NVE7 | PANK4 | S387 | ochoa | 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) | Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}. |
| Q9NY59 | SMPD3 | S203 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NZB2 | FAM120A | S506 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P0K7 | RAI14 | S317 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P242 | NYAP2 | S412 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P2J2 | IGSF9 | S795 | ochoa | Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) | Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}. |
| Q9P2Q2 | FRMD4A | S795 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UJF2 | RASAL2 | S887 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UJU6 | DBNL | S141 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q9UK61 | TASOR | S68 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKE5 | TNIK | S610 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKK3 | PARP4 | S1489 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9Y2U8 | LEMD3 | S420 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2W1 | THRAP3 | S219 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3Q8 | TSC22D4 | S301 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4H2 | IRS2 | S518 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4J8 | DTNA | S609 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y5X1 | SNX9 | S116 | ochoa | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| P26373 | RPL13 | S181 | Sugiyama | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
| P20618 | PSMB1 | S151 | Sugiyama | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| Q12931 | TRAP1 | S477 | Sugiyama | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| P34897 | SHMT2 | S90 | Sugiyama | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| O94804 | STK10 | S444 | Sugiyama | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| Q9BT78 | COPS4 | S297 | Sugiyama | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| Q15751 | HERC1 | S3244 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| O43242 | PSMD3 | S63 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O60664 | PLIN3 | S76 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| Q8N568 | DCLK2 | S182 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| P20933 | AGA | S59 | Sugiyama | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. {ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874, ECO:0000269|PubMed:2401370}. |
| Q9H1R3 | MYLK2 | S72 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q9UK32 | RPS6KA6 | S712 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9764561 | Regulation of CDH1 Function | 6.170146e-10 | 9.210 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 6.201145e-08 | 7.208 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 8.790127e-08 | 7.056 |
| R-HSA-1500931 | Cell-Cell communication | 5.005594e-07 | 6.301 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.178741e-05 | 4.929 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.178741e-05 | 4.929 |
| R-HSA-446728 | Cell junction organization | 2.008547e-05 | 4.697 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.079779e-05 | 4.511 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.064459e-05 | 4.514 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.001706e-05 | 4.398 |
| R-HSA-422475 | Axon guidance | 6.183659e-05 | 4.209 |
| R-HSA-418990 | Adherens junctions interactions | 7.101520e-05 | 4.149 |
| R-HSA-373753 | Nephrin family interactions | 8.850807e-05 | 4.053 |
| R-HSA-9675108 | Nervous system development | 1.280818e-04 | 3.893 |
| R-HSA-421270 | Cell-cell junction organization | 2.021954e-04 | 3.694 |
| R-HSA-68882 | Mitotic Anaphase | 3.328324e-04 | 3.478 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.431270e-04 | 3.465 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.015712e-04 | 3.396 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.230139e-04 | 3.141 |
| R-HSA-1474244 | Extracellular matrix organization | 1.459625e-03 | 2.836 |
| R-HSA-162582 | Signal Transduction | 1.419744e-03 | 2.848 |
| R-HSA-109581 | Apoptosis | 1.370317e-03 | 2.863 |
| R-HSA-75153 | Apoptotic execution phase | 1.573391e-03 | 2.803 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.036549e-03 | 2.691 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.164651e-03 | 2.665 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.300136e-03 | 2.638 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.511668e-03 | 2.600 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 3.846601e-03 | 2.415 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.062704e-03 | 2.391 |
| R-HSA-196025 | Formation of annular gap junctions | 4.626926e-03 | 2.335 |
| R-HSA-5357801 | Programmed Cell Death | 4.678907e-03 | 2.330 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 9.025935e-03 | 2.045 |
| R-HSA-190873 | Gap junction degradation | 5.473960e-03 | 2.262 |
| R-HSA-4839744 | Signaling by APC mutants | 7.363164e-03 | 2.133 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 7.363164e-03 | 2.133 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 7.363164e-03 | 2.133 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 7.363164e-03 | 2.133 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 8.402883e-03 | 2.076 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 9.504407e-03 | 2.022 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 9.504407e-03 | 2.022 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 9.504407e-03 | 2.022 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 9.504407e-03 | 2.022 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 9.504407e-03 | 2.022 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.605927e-03 | 2.180 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 9.462692e-03 | 2.024 |
| R-HSA-180746 | Nuclear import of Rev protein | 6.396679e-03 | 2.194 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 9.805050e-03 | 2.009 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 7.752377e-03 | 2.111 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.036286e-02 | 1.985 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.799238e-03 | 2.237 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 6.386450e-03 | 2.195 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.036286e-02 | 1.985 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.056840e-02 | 1.976 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 8.402883e-03 | 2.076 |
| R-HSA-4839735 | Signaling by AXIN mutants | 8.402883e-03 | 2.076 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 9.265215e-03 | 2.033 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.036286e-02 | 1.985 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.036286e-02 | 1.985 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.605927e-03 | 2.180 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.604758e-03 | 2.180 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 8.743242e-03 | 2.058 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.056840e-02 | 1.976 |
| R-HSA-2559585 | Oncogene Induced Senescence | 6.831366e-03 | 2.165 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.299690e-03 | 2.276 |
| R-HSA-9659379 | Sensory processing of sound | 8.435226e-03 | 2.074 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.816140e-03 | 2.055 |
| R-HSA-168255 | Influenza Infection | 9.747488e-03 | 2.011 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.571344e-03 | 2.182 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.890508e-03 | 2.162 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.095473e-02 | 1.960 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.095473e-02 | 1.960 |
| R-HSA-68886 | M Phase | 1.163634e-02 | 1.934 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.316804e-02 | 1.880 |
| R-HSA-6798695 | Neutrophil degranulation | 1.221818e-02 | 1.913 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.342514e-02 | 1.872 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.342514e-02 | 1.872 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.342514e-02 | 1.872 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.342514e-02 | 1.872 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.214522e-02 | 1.916 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.277595e-02 | 1.894 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.277595e-02 | 1.894 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.396743e-02 | 1.855 |
| R-HSA-437239 | Recycling pathway of L1 | 1.409284e-02 | 1.851 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.437560e-02 | 1.842 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.484551e-02 | 1.828 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.631316e-02 | 1.787 |
| R-HSA-9766229 | Degradation of CDH1 | 1.548405e-02 | 1.810 |
| R-HSA-1640170 | Cell Cycle | 1.571659e-02 | 1.804 |
| R-HSA-9827857 | Specification of primordial germ cells | 1.734622e-02 | 1.761 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.771120e-02 | 1.752 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.797095e-02 | 1.745 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.849116e-02 | 1.733 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.895565e-02 | 1.722 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.010765e-02 | 1.697 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.094421e-02 | 1.679 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.179967e-02 | 1.662 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.130081e-02 | 1.672 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.849116e-02 | 1.733 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.200909e-02 | 1.657 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.993470e-02 | 1.700 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.040274e-02 | 1.690 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 1.884810e-02 | 1.725 |
| R-HSA-70171 | Glycolysis | 1.895565e-02 | 1.722 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.094421e-02 | 1.679 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.845742e-02 | 1.734 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.366610e-02 | 1.626 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.370799e-02 | 1.625 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.370799e-02 | 1.625 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.499901e-02 | 1.602 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.499901e-02 | 1.602 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.537273e-02 | 1.596 |
| R-HSA-162906 | HIV Infection | 2.577422e-02 | 1.589 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.636038e-02 | 1.579 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.636038e-02 | 1.579 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.683578e-02 | 1.571 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.712798e-02 | 1.567 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.732914e-02 | 1.563 |
| R-HSA-1296067 | Potassium transport channels | 3.562113e-02 | 1.448 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.932313e-02 | 1.533 |
| R-HSA-525793 | Myogenesis | 3.461520e-02 | 1.461 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 3.562113e-02 | 1.448 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.461520e-02 | 1.461 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.521632e-02 | 1.453 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.058269e-02 | 1.515 |
| R-HSA-3000170 | Syndecan interactions | 2.893083e-02 | 1.539 |
| R-HSA-70326 | Glucose metabolism | 3.208452e-02 | 1.494 |
| R-HSA-2559583 | Cellular Senescence | 3.572515e-02 | 1.447 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.461520e-02 | 1.461 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.362902e-02 | 1.473 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.575417e-02 | 1.447 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.575417e-02 | 1.447 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.575417e-02 | 1.447 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 4.432770e-02 | 1.353 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.295620e-02 | 1.276 |
| R-HSA-74713 | IRS activation | 6.150733e-02 | 1.211 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 6.998177e-02 | 1.155 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 6.998177e-02 | 1.155 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.069321e-02 | 1.390 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.280235e-02 | 1.369 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.495156e-02 | 1.347 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.495156e-02 | 1.347 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.936665e-02 | 1.307 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.936665e-02 | 1.307 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.936665e-02 | 1.307 |
| R-HSA-390522 | Striated Muscle Contraction | 5.163080e-02 | 1.287 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.163080e-02 | 1.287 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.626807e-02 | 1.250 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.595554e-02 | 1.181 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.845879e-02 | 1.165 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.339204e-02 | 1.198 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.489814e-02 | 1.188 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.108586e-02 | 1.148 |
| R-HSA-156902 | Peptide chain elongation | 5.897365e-02 | 1.229 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 4.432770e-02 | 1.353 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 6.150733e-02 | 1.211 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.713995e-02 | 1.327 |
| R-HSA-417973 | Adenosine P1 receptors | 4.432770e-02 | 1.353 |
| R-HSA-187024 | NGF-independant TRKA activation | 6.998177e-02 | 1.155 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.659871e-02 | 1.437 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.495156e-02 | 1.347 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 6.104513e-02 | 1.214 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.642069e-02 | 1.178 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.713995e-02 | 1.327 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.163080e-02 | 1.287 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.951467e-02 | 1.158 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 5.295620e-02 | 1.276 |
| R-HSA-429593 | Inositol transporters | 6.150733e-02 | 1.211 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.713995e-02 | 1.327 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.626807e-02 | 1.250 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.626807e-02 | 1.250 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.804628e-02 | 1.420 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.655671e-02 | 1.248 |
| R-HSA-390650 | Histamine receptors | 4.432770e-02 | 1.353 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.659871e-02 | 1.437 |
| R-HSA-4641258 | Degradation of DVL | 6.104513e-02 | 1.214 |
| R-HSA-5689603 | UCH proteinases | 4.162196e-02 | 1.381 |
| R-HSA-9664407 | Parasite infection | 5.551118e-02 | 1.256 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.551118e-02 | 1.256 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.551118e-02 | 1.256 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.863953e-02 | 1.232 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.863953e-02 | 1.232 |
| R-HSA-4641257 | Degradation of AXIN | 6.104513e-02 | 1.214 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 6.104513e-02 | 1.214 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 6.845879e-02 | 1.165 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.664316e-02 | 1.331 |
| R-HSA-5250982 | Toxicity of tetanus toxin (tetX) | 5.295620e-02 | 1.276 |
| R-HSA-5250989 | Toxicity of botulinum toxin type G (botG) | 6.150733e-02 | 1.211 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 6.998177e-02 | 1.155 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 6.998177e-02 | 1.155 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.163080e-02 | 1.287 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.163080e-02 | 1.287 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.393155e-02 | 1.268 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.393155e-02 | 1.268 |
| R-HSA-169911 | Regulation of Apoptosis | 5.626807e-02 | 1.250 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.348407e-02 | 1.197 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.194935e-02 | 1.284 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.042968e-02 | 1.219 |
| R-HSA-114608 | Platelet degranulation | 4.110998e-02 | 1.386 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 6.845879e-02 | 1.165 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 7.099304e-02 | 1.149 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 7.099304e-02 | 1.149 |
| R-HSA-397014 | Muscle contraction | 6.109884e-02 | 1.214 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 6.595554e-02 | 1.181 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 6.595554e-02 | 1.181 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.753047e-02 | 1.323 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.626807e-02 | 1.250 |
| R-HSA-194138 | Signaling by VEGF | 3.937233e-02 | 1.405 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.862503e-02 | 1.413 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 6.845879e-02 | 1.165 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 7.099304e-02 | 1.149 |
| R-HSA-69306 | DNA Replication | 7.110394e-02 | 1.148 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.863953e-02 | 1.232 |
| R-HSA-69541 | Stabilization of p53 | 6.595554e-02 | 1.181 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.041182e-02 | 1.393 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.409028e-02 | 1.193 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.713995e-02 | 1.327 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.305156e-02 | 1.200 |
| R-HSA-9758941 | Gastrulation | 6.644044e-02 | 1.178 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.229549e-02 | 1.141 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.267301e-02 | 1.139 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.267301e-02 | 1.139 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 7.355754e-02 | 1.133 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 7.355754e-02 | 1.133 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 7.355754e-02 | 1.133 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 7.838021e-02 | 1.106 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 7.838021e-02 | 1.106 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 7.838021e-02 | 1.106 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 8.670332e-02 | 1.062 |
| R-HSA-112412 | SOS-mediated signalling | 8.670332e-02 | 1.062 |
| R-HSA-444257 | RSK activation | 9.495177e-02 | 1.022 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.495177e-02 | 1.022 |
| R-HSA-9613354 | Lipophagy | 1.031262e-01 | 0.987 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.112274e-01 | 0.954 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.112274e-01 | 0.954 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.112274e-01 | 0.954 |
| R-HSA-428540 | Activation of RAC1 | 1.272123e-01 | 0.895 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.272123e-01 | 0.895 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.350973e-01 | 0.869 |
| R-HSA-72187 | mRNA 3'-end processing | 1.035583e-01 | 0.985 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.064308e-01 | 0.973 |
| R-HSA-192823 | Viral mRNA Translation | 8.592938e-02 | 1.066 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.469903e-02 | 1.024 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 9.649573e-02 | 1.015 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 9.649573e-02 | 1.015 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.421921e-02 | 1.075 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.272123e-01 | 0.895 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.038203e-01 | 0.984 |
| R-HSA-198203 | PI3K/AKT activation | 1.112274e-01 | 0.954 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.038203e-01 | 0.984 |
| R-HSA-173107 | Binding and entry of HIV virion | 1.112274e-01 | 0.954 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 8.680811e-02 | 1.061 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.064308e-01 | 0.973 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.152045e-01 | 0.939 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.152045e-01 | 0.939 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.429116e-01 | 0.845 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 8.410331e-02 | 1.075 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 8.680811e-02 | 1.061 |
| R-HSA-5696398 | Nucleotide Excision Repair | 9.114798e-02 | 1.040 |
| R-HSA-74749 | Signal attenuation | 1.112274e-01 | 0.954 |
| R-HSA-9711097 | Cellular response to starvation | 7.716342e-02 | 1.113 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.421921e-02 | 1.075 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.112274e-01 | 0.954 |
| R-HSA-9907900 | Proteasome assembly | 8.142515e-02 | 1.089 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.112274e-01 | 0.954 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.192558e-01 | 0.924 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 8.953886e-02 | 1.048 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.064308e-01 | 0.973 |
| R-HSA-191859 | snRNP Assembly | 1.240935e-01 | 0.906 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.240935e-01 | 0.906 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.301300e-01 | 0.886 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 8.953886e-02 | 1.048 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 9.495177e-02 | 1.022 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.252394e-02 | 1.083 |
| R-HSA-199991 | Membrane Trafficking | 8.408365e-02 | 1.075 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.240935e-01 | 0.906 |
| R-HSA-187015 | Activation of TRKA receptors | 8.670332e-02 | 1.062 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.031262e-01 | 0.987 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.035583e-01 | 0.985 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.093246e-01 | 0.961 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.301300e-01 | 0.886 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.765433e-02 | 1.057 |
| R-HSA-68877 | Mitotic Prometaphase | 1.278620e-01 | 0.893 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.486241e-01 | 0.828 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 7.838021e-02 | 1.106 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 7.838021e-02 | 1.106 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 9.495177e-02 | 1.022 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.506557e-01 | 0.822 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.506557e-01 | 0.822 |
| R-HSA-190828 | Gap junction trafficking | 8.142515e-02 | 1.089 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 8.680811e-02 | 1.061 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.035583e-01 | 0.985 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.765433e-02 | 1.057 |
| R-HSA-5610787 | Hedgehog 'off' state | 8.084373e-02 | 1.092 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.506557e-01 | 0.822 |
| R-HSA-157858 | Gap junction trafficking and regulation | 9.507547e-02 | 1.022 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.961447e-02 | 1.002 |
| R-HSA-202403 | TCR signaling | 1.001308e-01 | 0.999 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.506557e-01 | 0.822 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 7.877432e-02 | 1.104 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 8.142515e-02 | 1.089 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 8.410331e-02 | 1.075 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 8.410331e-02 | 1.075 |
| R-HSA-69481 | G2/M Checkpoints | 1.392846e-01 | 0.856 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 9.649573e-02 | 1.015 |
| R-HSA-68875 | Mitotic Prophase | 1.230449e-01 | 0.910 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.126007e-01 | 0.948 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.031262e-01 | 0.987 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.429116e-01 | 0.845 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 8.410331e-02 | 1.075 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 8.953886e-02 | 1.048 |
| R-HSA-69239 | Synthesis of DNA | 9.469903e-02 | 1.024 |
| R-HSA-373760 | L1CAM interactions | 1.152045e-01 | 0.939 |
| R-HSA-2586552 | Signaling by Leptin | 1.112274e-01 | 0.954 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.301300e-01 | 0.886 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.031262e-01 | 0.987 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.007078e-01 | 0.997 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.331737e-01 | 0.876 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.007078e-01 | 0.997 |
| R-HSA-5688426 | Deubiquitination | 1.061978e-01 | 0.974 |
| R-HSA-417957 | P2Y receptors | 1.506557e-01 | 0.822 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.064308e-01 | 0.973 |
| R-HSA-8983711 | OAS antiviral response | 1.350973e-01 | 0.869 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.007078e-01 | 0.997 |
| R-HSA-186797 | Signaling by PDGF | 1.331737e-01 | 0.876 |
| R-HSA-70263 | Gluconeogenesis | 9.229487e-02 | 1.035 |
| R-HSA-351202 | Metabolism of polyamines | 1.271032e-01 | 0.896 |
| R-HSA-2262752 | Cellular responses to stress | 8.986625e-02 | 1.046 |
| R-HSA-9824272 | Somitogenesis | 8.410331e-02 | 1.075 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.423995e-01 | 0.846 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 9.507547e-02 | 1.022 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 9.507547e-02 | 1.022 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.301300e-01 | 0.886 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.680934e-02 | 1.014 |
| R-HSA-69206 | G1/S Transition | 1.351579e-01 | 0.869 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 9.229487e-02 | 1.035 |
| R-HSA-8953854 | Metabolism of RNA | 1.553676e-01 | 0.809 |
| R-HSA-112316 | Neuronal System | 1.574844e-01 | 0.803 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.580616e-01 | 0.801 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.580616e-01 | 0.801 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.580616e-01 | 0.801 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.583304e-01 | 0.800 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.583304e-01 | 0.800 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.583304e-01 | 0.800 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.583304e-01 | 0.800 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.583304e-01 | 0.800 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.593323e-01 | 0.798 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.612323e-01 | 0.793 |
| R-HSA-168249 | Innate Immune System | 1.640600e-01 | 0.785 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.644147e-01 | 0.784 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.644147e-01 | 0.784 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.644147e-01 | 0.784 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.644147e-01 | 0.784 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.644147e-01 | 0.784 |
| R-HSA-5635838 | Activation of SMO | 1.659362e-01 | 0.780 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.659362e-01 | 0.780 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.670906e-01 | 0.777 |
| R-HSA-6807070 | PTEN Regulation | 1.692944e-01 | 0.771 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.734737e-01 | 0.761 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.734737e-01 | 0.761 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.734737e-01 | 0.761 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.734737e-01 | 0.761 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.740274e-01 | 0.759 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 1.740274e-01 | 0.759 |
| R-HSA-1266738 | Developmental Biology | 1.762645e-01 | 0.754 |
| R-HSA-8951664 | Neddylation | 1.765072e-01 | 0.753 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.804858e-01 | 0.744 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.837287e-01 | 0.736 |
| R-HSA-5619084 | ABC transporter disorders | 1.837287e-01 | 0.736 |
| R-HSA-4086400 | PCP/CE pathway | 1.837287e-01 | 0.736 |
| R-HSA-3928664 | Ephrin signaling | 1.883464e-01 | 0.725 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.883464e-01 | 0.725 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.883464e-01 | 0.725 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.883464e-01 | 0.725 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.883464e-01 | 0.725 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.883464e-01 | 0.725 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.883464e-01 | 0.725 |
| R-HSA-69242 | S Phase | 1.917753e-01 | 0.717 |
| R-HSA-166520 | Signaling by NTRKs | 1.917753e-01 | 0.717 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.956828e-01 | 0.708 |
| R-HSA-449836 | Other interleukin signaling | 1.956828e-01 | 0.708 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.000635e-01 | 0.699 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.018393e-01 | 0.695 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.029533e-01 | 0.693 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.029533e-01 | 0.693 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.029533e-01 | 0.693 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.033517e-01 | 0.692 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.066461e-01 | 0.685 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.099463e-01 | 0.678 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.101585e-01 | 0.677 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.101585e-01 | 0.677 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.101585e-01 | 0.677 |
| R-HSA-210991 | Basigin interactions | 2.101585e-01 | 0.677 |
| R-HSA-157118 | Signaling by NOTCH | 2.113152e-01 | 0.675 |
| R-HSA-162587 | HIV Life Cycle | 2.126137e-01 | 0.672 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.165625e-01 | 0.664 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.172990e-01 | 0.663 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.172990e-01 | 0.663 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.172990e-01 | 0.663 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.188009e-01 | 0.660 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.208740e-01 | 0.656 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.243755e-01 | 0.649 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 2.243755e-01 | 0.649 |
| R-HSA-112310 | Neurotransmitter release cycle | 2.265214e-01 | 0.645 |
| R-HSA-202424 | Downstream TCR signaling | 2.265214e-01 | 0.645 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.291484e-01 | 0.640 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.298488e-01 | 0.639 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.313883e-01 | 0.636 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.313883e-01 | 0.636 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.313883e-01 | 0.636 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.326585e-01 | 0.633 |
| R-HSA-5619102 | SLC transporter disorders | 2.363090e-01 | 0.627 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.365133e-01 | 0.626 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.383382e-01 | 0.623 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.383382e-01 | 0.623 |
| R-HSA-9824446 | Viral Infection Pathways | 2.425145e-01 | 0.615 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.443446e-01 | 0.612 |
| R-HSA-9620244 | Long-term potentiation | 2.452257e-01 | 0.610 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.452257e-01 | 0.610 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.452257e-01 | 0.610 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.452257e-01 | 0.610 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.452257e-01 | 0.610 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.459172e-01 | 0.609 |
| R-HSA-72306 | tRNA processing | 2.459172e-01 | 0.609 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.520513e-01 | 0.599 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 2.520513e-01 | 0.599 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 2.520513e-01 | 0.599 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.520513e-01 | 0.599 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.531642e-01 | 0.597 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.532161e-01 | 0.597 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.557469e-01 | 0.592 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.565613e-01 | 0.591 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.580130e-01 | 0.588 |
| R-HSA-8949613 | Cristae formation | 2.588157e-01 | 0.587 |
| R-HSA-264876 | Insulin processing | 2.588157e-01 | 0.587 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.588157e-01 | 0.587 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 2.588157e-01 | 0.587 |
| R-HSA-73894 | DNA Repair | 2.630151e-01 | 0.580 |
| R-HSA-3214847 | HATs acetylate histones | 2.632539e-01 | 0.580 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.666009e-01 | 0.574 |
| R-HSA-9679506 | SARS-CoV Infections | 2.688124e-01 | 0.571 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.699478e-01 | 0.569 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.721625e-01 | 0.565 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.721625e-01 | 0.565 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.721625e-01 | 0.565 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.732945e-01 | 0.563 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.732945e-01 | 0.563 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.776501e-01 | 0.557 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.787462e-01 | 0.555 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.787462e-01 | 0.555 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.787462e-01 | 0.555 |
| R-HSA-1643685 | Disease | 2.795212e-01 | 0.554 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.799860e-01 | 0.553 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.852707e-01 | 0.545 |
| R-HSA-186763 | Downstream signal transduction | 2.852707e-01 | 0.545 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.877096e-01 | 0.541 |
| R-HSA-5663205 | Infectious disease | 2.890360e-01 | 0.539 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.897990e-01 | 0.538 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.900149e-01 | 0.538 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 2.917366e-01 | 0.535 |
| R-HSA-9658195 | Leishmania infection | 2.917487e-01 | 0.535 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.917487e-01 | 0.535 |
| R-HSA-211000 | Gene Silencing by RNA | 2.933546e-01 | 0.533 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.937712e-01 | 0.532 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.966923e-01 | 0.528 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.981444e-01 | 0.526 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.981444e-01 | 0.526 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.981444e-01 | 0.526 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.981444e-01 | 0.526 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.044946e-01 | 0.516 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.044946e-01 | 0.516 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.044946e-01 | 0.516 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.047923e-01 | 0.516 |
| R-HSA-9609690 | HCMV Early Events | 3.095140e-01 | 0.509 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.100183e-01 | 0.509 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.107878e-01 | 0.508 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.107878e-01 | 0.508 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.166633e-01 | 0.499 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.166633e-01 | 0.499 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.170244e-01 | 0.499 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.193930e-01 | 0.496 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.232049e-01 | 0.491 |
| R-HSA-163560 | Triglyceride catabolism | 3.232049e-01 | 0.491 |
| R-HSA-8853659 | RET signaling | 3.232049e-01 | 0.491 |
| R-HSA-195721 | Signaling by WNT | 3.263485e-01 | 0.486 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.293299e-01 | 0.482 |
| R-HSA-419037 | NCAM1 interactions | 3.293299e-01 | 0.482 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.293299e-01 | 0.482 |
| R-HSA-8948216 | Collagen chain trimerization | 3.293299e-01 | 0.482 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.293299e-01 | 0.482 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.365060e-01 | 0.473 |
| R-HSA-5693538 | Homology Directed Repair | 3.365060e-01 | 0.473 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.414152e-01 | 0.467 |
| R-HSA-3371556 | Cellular response to heat stress | 3.463659e-01 | 0.460 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.463659e-01 | 0.460 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.473765e-01 | 0.459 |
| R-HSA-202433 | Generation of second messenger molecules | 3.473765e-01 | 0.459 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.473765e-01 | 0.459 |
| R-HSA-5260271 | Diseases of Immune System | 3.473765e-01 | 0.459 |
| R-HSA-71240 | Tryptophan catabolism | 3.473765e-01 | 0.459 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.515014e-01 | 0.454 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.532842e-01 | 0.452 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.532842e-01 | 0.452 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.532842e-01 | 0.452 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.532842e-01 | 0.452 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.591388e-01 | 0.445 |
| R-HSA-9683701 | Translation of Structural Proteins | 3.591388e-01 | 0.445 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 3.598828e-01 | 0.444 |
| R-HSA-165159 | MTOR signalling | 3.649407e-01 | 0.438 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.649407e-01 | 0.438 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.706905e-01 | 0.431 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.724145e-01 | 0.429 |
| R-HSA-5683826 | Surfactant metabolism | 3.763886e-01 | 0.424 |
| R-HSA-69236 | G1 Phase | 3.763886e-01 | 0.424 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.763886e-01 | 0.424 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.763886e-01 | 0.424 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.776216e-01 | 0.423 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.820354e-01 | 0.418 |
| R-HSA-1474165 | Reproduction | 3.820788e-01 | 0.418 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.858950e-01 | 0.414 |
| R-HSA-72766 | Translation | 3.869954e-01 | 0.412 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.876314e-01 | 0.412 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.876314e-01 | 0.412 |
| R-HSA-9909396 | Circadian clock | 3.884869e-01 | 0.411 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.907790e-01 | 0.408 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 3.956536e-01 | 0.403 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.986730e-01 | 0.399 |
| R-HSA-72312 | rRNA processing | 4.005183e-01 | 0.397 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 4.041194e-01 | 0.393 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.043782e-01 | 0.393 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.053725e-01 | 0.392 |
| R-HSA-109704 | PI3K Cascade | 4.095168e-01 | 0.388 |
| R-HSA-9748787 | Azathioprine ADME | 4.095168e-01 | 0.388 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.143826e-01 | 0.383 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 4.148656e-01 | 0.382 |
| R-HSA-1632852 | Macroautophagy | 4.200728e-01 | 0.377 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.201663e-01 | 0.377 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.201663e-01 | 0.377 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.254194e-01 | 0.371 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.254194e-01 | 0.371 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.262924e-01 | 0.370 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.262924e-01 | 0.370 |
| R-HSA-72649 | Translation initiation complex formation | 4.306251e-01 | 0.366 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.306251e-01 | 0.366 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.324775e-01 | 0.364 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.408965e-01 | 0.356 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.408965e-01 | 0.356 |
| R-HSA-75893 | TNF signaling | 4.408965e-01 | 0.356 |
| R-HSA-4839726 | Chromatin organization | 4.413850e-01 | 0.355 |
| R-HSA-9609646 | HCMV Infection | 4.437579e-01 | 0.353 |
| R-HSA-112399 | IRS-mediated signalling | 4.459630e-01 | 0.351 |
| R-HSA-109582 | Hemostasis | 4.468092e-01 | 0.350 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.509839e-01 | 0.346 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.509839e-01 | 0.346 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.538428e-01 | 0.343 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.559596e-01 | 0.341 |
| R-HSA-8979227 | Triglyceride metabolism | 4.559596e-01 | 0.341 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.559596e-01 | 0.341 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.568579e-01 | 0.340 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.568579e-01 | 0.340 |
| R-HSA-9609507 | Protein localization | 4.598636e-01 | 0.337 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.598636e-01 | 0.337 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.608905e-01 | 0.336 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.608905e-01 | 0.336 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.657770e-01 | 0.332 |
| R-HSA-1442490 | Collagen degradation | 4.657770e-01 | 0.332 |
| R-HSA-9612973 | Autophagy | 4.688228e-01 | 0.329 |
| R-HSA-1268020 | Mitochondrial protein import | 4.706195e-01 | 0.327 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.706195e-01 | 0.327 |
| R-HSA-9610379 | HCMV Late Events | 4.717897e-01 | 0.326 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.747468e-01 | 0.324 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.801741e-01 | 0.319 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.801741e-01 | 0.319 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.848870e-01 | 0.314 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.941859e-01 | 0.306 |
| R-HSA-196807 | Nicotinate metabolism | 4.941859e-01 | 0.306 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 4.987726e-01 | 0.302 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.987726e-01 | 0.302 |
| R-HSA-913531 | Interferon Signaling | 4.998505e-01 | 0.301 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.078224e-01 | 0.294 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 5.078224e-01 | 0.294 |
| R-HSA-3000178 | ECM proteoglycans | 5.122863e-01 | 0.290 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.150785e-01 | 0.288 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.178811e-01 | 0.286 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 5.208985e-01 | 0.283 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.254382e-01 | 0.279 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.254382e-01 | 0.279 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.262246e-01 | 0.279 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.340097e-01 | 0.272 |
| R-HSA-611105 | Respiratory electron transport | 5.344712e-01 | 0.272 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.424276e-01 | 0.266 |
| R-HSA-216083 | Integrin cell surface interactions | 5.424276e-01 | 0.266 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.465796e-01 | 0.262 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.506943e-01 | 0.259 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.547719e-01 | 0.256 |
| R-HSA-69275 | G2/M Transition | 5.559820e-01 | 0.255 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.612496e-01 | 0.251 |
| R-HSA-168256 | Immune System | 5.622039e-01 | 0.250 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.823041e-01 | 0.235 |
| R-HSA-70268 | Pyruvate metabolism | 5.823041e-01 | 0.235 |
| R-HSA-9663891 | Selective autophagy | 5.860967e-01 | 0.232 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.919202e-01 | 0.228 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.993363e-01 | 0.222 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.045528e-01 | 0.219 |
| R-HSA-391251 | Protein folding | 6.045528e-01 | 0.219 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.117042e-01 | 0.213 |
| R-HSA-1474290 | Collagen formation | 6.117042e-01 | 0.213 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.221913e-01 | 0.206 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.221913e-01 | 0.206 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.221913e-01 | 0.206 |
| R-HSA-1296071 | Potassium Channels | 6.221913e-01 | 0.206 |
| R-HSA-422356 | Regulation of insulin secretion | 6.290259e-01 | 0.201 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.292014e-01 | 0.201 |
| R-HSA-392499 | Metabolism of proteins | 6.293428e-01 | 0.201 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.551579e-01 | 0.184 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.644788e-01 | 0.178 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.675298e-01 | 0.176 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.705533e-01 | 0.174 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.705533e-01 | 0.174 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 6.784573e-01 | 0.168 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.790662e-01 | 0.168 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.794608e-01 | 0.168 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.881291e-01 | 0.162 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.881291e-01 | 0.162 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.909665e-01 | 0.161 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.965646e-01 | 0.157 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.965646e-01 | 0.157 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.074604e-01 | 0.150 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.127616e-01 | 0.147 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 7.127616e-01 | 0.147 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.158508e-01 | 0.145 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.205351e-01 | 0.142 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.205351e-01 | 0.142 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.205351e-01 | 0.142 |
| R-HSA-74160 | Gene expression (Transcription) | 7.324600e-01 | 0.135 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.330294e-01 | 0.135 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.375524e-01 | 0.132 |
| R-HSA-9843745 | Adipogenesis | 7.378703e-01 | 0.132 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.402579e-01 | 0.131 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.402579e-01 | 0.131 |
| R-HSA-163685 | Integration of energy metabolism | 7.518761e-01 | 0.124 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.541370e-01 | 0.123 |
| R-HSA-597592 | Post-translational protein modification | 7.652489e-01 | 0.116 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.776965e-01 | 0.109 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.797237e-01 | 0.108 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.826855e-01 | 0.106 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.837231e-01 | 0.106 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.837231e-01 | 0.106 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.915069e-01 | 0.102 |
| R-HSA-73887 | Death Receptor Signaling | 7.915069e-01 | 0.102 |
| R-HSA-1989781 | PPARA activates gene expression | 7.934090e-01 | 0.101 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.971615e-01 | 0.098 |
| R-HSA-500792 | GPCR ligand binding | 8.071858e-01 | 0.093 |
| R-HSA-418555 | G alpha (s) signalling events | 8.232297e-01 | 0.084 |
| R-HSA-449147 | Signaling by Interleukins | 8.411383e-01 | 0.075 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.459676e-01 | 0.073 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.528815e-01 | 0.069 |
| R-HSA-428157 | Sphingolipid metabolism | 8.657982e-01 | 0.063 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.670262e-01 | 0.062 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.682430e-01 | 0.061 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.809198e-01 | 0.055 |
| R-HSA-9748784 | Drug ADME | 8.862741e-01 | 0.052 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.893259e-01 | 0.051 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.948685e-01 | 0.048 |
| R-HSA-418594 | G alpha (i) signalling events | 9.023428e-01 | 0.045 |
| R-HSA-15869 | Metabolism of nucleotides | 9.036440e-01 | 0.044 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.180220e-01 | 0.037 |
| R-HSA-416476 | G alpha (q) signalling events | 9.255703e-01 | 0.034 |
| R-HSA-1280218 | Adaptive Immune System | 9.264672e-01 | 0.033 |
| R-HSA-388396 | GPCR downstream signalling | 9.332697e-01 | 0.030 |
| R-HSA-1483257 | Phospholipid metabolism | 9.441057e-01 | 0.025 |
| R-HSA-382551 | Transport of small molecules | 9.529100e-01 | 0.021 |
| R-HSA-212436 | Generic Transcription Pathway | 9.537830e-01 | 0.021 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.556510e-01 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 9.572642e-01 | 0.019 |
| R-HSA-372790 | Signaling by GPCR | 9.604219e-01 | 0.018 |
| R-HSA-1430728 | Metabolism | 9.735171e-01 | 0.012 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.829704e-01 | 0.007 |
| R-HSA-5668914 | Diseases of metabolism | 9.837461e-01 | 0.007 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.886012e-01 | 0.005 |
| R-HSA-9709957 | Sensory Perception | 9.972277e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.984038e-01 | 0.001 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.803 | 0.118 | 2 | 0.866 |
PRKD1 |
0.794 | 0.131 | -3 | 0.389 |
CLK3 |
0.788 | 0.066 | 1 | 0.721 |
DSTYK |
0.786 | 0.059 | 2 | 0.893 |
SRPK1 |
0.786 | 0.044 | -3 | 0.301 |
CDC7 |
0.784 | 0.039 | 1 | 0.777 |
PRPK |
0.784 | 0.046 | -1 | 0.812 |
PRKD2 |
0.784 | 0.035 | -3 | 0.327 |
PIM3 |
0.783 | 0.007 | -3 | 0.311 |
RSK2 |
0.783 | 0.020 | -3 | 0.298 |
MAPKAPK2 |
0.783 | 0.020 | -3 | 0.281 |
IKKB |
0.782 | -0.026 | -2 | 0.728 |
SKMLCK |
0.781 | 0.078 | -2 | 0.801 |
MTOR |
0.781 | -0.030 | 1 | 0.720 |
MOS |
0.781 | 0.050 | 1 | 0.771 |
ERK5 |
0.779 | 0.074 | 1 | 0.742 |
MAPKAPK3 |
0.779 | 0.018 | -3 | 0.330 |
NEK6 |
0.778 | 0.026 | -2 | 0.843 |
P90RSK |
0.778 | 0.007 | -3 | 0.300 |
CAMK2D |
0.778 | 0.040 | -3 | 0.348 |
ULK2 |
0.778 | -0.021 | 2 | 0.785 |
GCN2 |
0.777 | -0.063 | 2 | 0.801 |
WNK1 |
0.777 | 0.030 | -2 | 0.839 |
CAMK2G |
0.777 | -0.003 | 2 | 0.787 |
NDR2 |
0.775 | -0.025 | -3 | 0.316 |
CDKL1 |
0.775 | -0.013 | -3 | 0.302 |
NUAK2 |
0.775 | 0.007 | -3 | 0.322 |
GRK1 |
0.775 | 0.037 | -2 | 0.720 |
CDKL5 |
0.775 | 0.008 | -3 | 0.310 |
NLK |
0.775 | 0.018 | 1 | 0.731 |
ATR |
0.775 | 0.005 | 1 | 0.760 |
CAMK1B |
0.774 | -0.016 | -3 | 0.337 |
BMPR1B |
0.774 | 0.148 | 1 | 0.815 |
PKN2 |
0.774 | 0.022 | -3 | 0.334 |
IKKE |
0.774 | -0.034 | 1 | 0.676 |
PKN3 |
0.774 | -0.011 | -3 | 0.310 |
CLK2 |
0.774 | 0.069 | -3 | 0.278 |
RAF1 |
0.773 | -0.045 | 1 | 0.778 |
TBK1 |
0.773 | -0.054 | 1 | 0.684 |
NEK7 |
0.773 | -0.036 | -3 | 0.343 |
RSK3 |
0.772 | -0.014 | -3 | 0.300 |
BMPR2 |
0.772 | -0.042 | -2 | 0.829 |
HIPK4 |
0.772 | 0.016 | 1 | 0.678 |
PDHK4 |
0.772 | -0.118 | 1 | 0.773 |
MST4 |
0.772 | 0.011 | 2 | 0.863 |
PIM1 |
0.772 | -0.008 | -3 | 0.281 |
TSSK2 |
0.771 | 0.088 | -5 | 0.900 |
MARK4 |
0.771 | 0.021 | 4 | 0.755 |
RIPK3 |
0.771 | -0.000 | 3 | 0.717 |
CAMK2A |
0.771 | 0.036 | 2 | 0.779 |
ULK1 |
0.770 | -0.042 | -3 | 0.337 |
MLK1 |
0.770 | -0.013 | 2 | 0.841 |
IKKA |
0.770 | -0.023 | -2 | 0.732 |
GRK6 |
0.770 | 0.036 | 1 | 0.805 |
GRK5 |
0.769 | -0.046 | -3 | 0.319 |
SRPK2 |
0.769 | -0.008 | -3 | 0.241 |
CHAK2 |
0.769 | -0.010 | -1 | 0.745 |
CAMK2B |
0.769 | 0.020 | 2 | 0.761 |
NEK9 |
0.769 | 0.010 | 2 | 0.841 |
HUNK |
0.767 | 0.000 | 2 | 0.788 |
NIK |
0.767 | -0.022 | -3 | 0.344 |
PDHK1 |
0.767 | -0.099 | 1 | 0.750 |
PRKD3 |
0.767 | 0.013 | -3 | 0.328 |
DAPK2 |
0.767 | 0.016 | -3 | 0.344 |
TGFBR2 |
0.766 | -0.025 | -2 | 0.737 |
CAMLCK |
0.766 | -0.010 | -2 | 0.772 |
KIS |
0.766 | -0.014 | 1 | 0.582 |
TGFBR1 |
0.765 | 0.076 | -2 | 0.747 |
SRPK3 |
0.765 | -0.001 | -3 | 0.259 |
TSSK1 |
0.765 | 0.026 | -3 | 0.360 |
PKCD |
0.765 | 0.003 | 2 | 0.808 |
CLK1 |
0.765 | 0.016 | -3 | 0.293 |
NDR1 |
0.764 | -0.062 | -3 | 0.313 |
PLK1 |
0.764 | 0.046 | -2 | 0.758 |
AURC |
0.764 | 0.003 | -2 | 0.555 |
RSK4 |
0.764 | -0.011 | -3 | 0.257 |
LATS2 |
0.764 | -0.037 | -5 | 0.728 |
PKCB |
0.763 | 0.029 | 2 | 0.772 |
FAM20C |
0.763 | 0.024 | 2 | 0.598 |
ICK |
0.763 | -0.016 | -3 | 0.336 |
AMPKA1 |
0.763 | -0.032 | -3 | 0.343 |
MLK2 |
0.763 | 0.014 | 2 | 0.837 |
MSK1 |
0.762 | -0.003 | -3 | 0.292 |
MASTL |
0.762 | -0.081 | -2 | 0.773 |
MSK2 |
0.762 | -0.037 | -3 | 0.292 |
MLK3 |
0.762 | 0.020 | 2 | 0.781 |
CLK4 |
0.761 | -0.009 | -3 | 0.285 |
CDK8 |
0.761 | -0.010 | 1 | 0.563 |
BCKDK |
0.761 | -0.093 | -1 | 0.686 |
NEK2 |
0.761 | 0.025 | 2 | 0.830 |
GRK7 |
0.761 | 0.018 | 1 | 0.742 |
PKACG |
0.760 | -0.053 | -2 | 0.646 |
P70S6KB |
0.760 | -0.054 | -3 | 0.295 |
CK1E |
0.760 | -0.039 | -3 | 0.177 |
PKACB |
0.760 | -0.013 | -2 | 0.576 |
NIM1 |
0.760 | -0.023 | 3 | 0.736 |
AMPKA2 |
0.760 | -0.038 | -3 | 0.321 |
ALK4 |
0.760 | 0.037 | -2 | 0.775 |
DYRK2 |
0.760 | 0.002 | 1 | 0.598 |
MNK2 |
0.760 | -0.016 | -2 | 0.713 |
CDK19 |
0.759 | -0.000 | 1 | 0.529 |
SMG1 |
0.759 | 0.012 | 1 | 0.713 |
JNK2 |
0.759 | 0.044 | 1 | 0.528 |
GSK3B |
0.759 | 0.120 | 4 | 0.609 |
ATM |
0.758 | -0.012 | 1 | 0.704 |
DLK |
0.758 | -0.071 | 1 | 0.789 |
ACVR2B |
0.758 | 0.066 | -2 | 0.753 |
CDK13 |
0.758 | 0.003 | 1 | 0.546 |
DRAK1 |
0.758 | 0.087 | 1 | 0.838 |
ACVR2A |
0.758 | 0.058 | -2 | 0.736 |
DNAPK |
0.757 | 0.032 | 1 | 0.650 |
IRE1 |
0.757 | -0.024 | 1 | 0.729 |
PKCG |
0.757 | -0.011 | 2 | 0.773 |
BRSK1 |
0.757 | -0.016 | -3 | 0.315 |
ANKRD3 |
0.757 | -0.043 | 1 | 0.794 |
AKT2 |
0.757 | -0.024 | -3 | 0.258 |
PKCA |
0.756 | 0.004 | 2 | 0.767 |
JNK3 |
0.756 | 0.028 | 1 | 0.553 |
GRK2 |
0.756 | 0.049 | -2 | 0.666 |
YSK4 |
0.756 | -0.013 | 1 | 0.726 |
RIPK1 |
0.756 | -0.100 | 1 | 0.764 |
QSK |
0.756 | -0.009 | 4 | 0.718 |
GRK4 |
0.756 | -0.094 | -2 | 0.767 |
PAK1 |
0.755 | -0.038 | -2 | 0.689 |
SGK3 |
0.755 | -0.015 | -3 | 0.307 |
MNK1 |
0.755 | -0.021 | -2 | 0.716 |
CDK1 |
0.755 | 0.001 | 1 | 0.555 |
CDK18 |
0.755 | 0.020 | 1 | 0.516 |
MYLK4 |
0.755 | -0.021 | -2 | 0.681 |
MELK |
0.755 | -0.048 | -3 | 0.326 |
CDK5 |
0.754 | 0.021 | 1 | 0.592 |
LATS1 |
0.754 | -0.014 | -3 | 0.319 |
GSK3A |
0.754 | 0.096 | 4 | 0.619 |
PRKX |
0.754 | -0.025 | -3 | 0.233 |
PKR |
0.754 | -0.001 | 1 | 0.761 |
CK1D |
0.754 | -0.044 | -3 | 0.159 |
CAMK4 |
0.754 | -0.097 | -3 | 0.305 |
NUAK1 |
0.753 | -0.061 | -3 | 0.289 |
MLK4 |
0.753 | -0.014 | 2 | 0.760 |
MARK3 |
0.753 | 0.007 | 4 | 0.672 |
TTBK2 |
0.753 | -0.110 | 2 | 0.701 |
WNK3 |
0.753 | -0.165 | 1 | 0.743 |
QIK |
0.752 | -0.059 | -3 | 0.332 |
PKCH |
0.752 | -0.017 | 2 | 0.754 |
CDK9 |
0.752 | 0.001 | 1 | 0.555 |
PAK3 |
0.752 | -0.053 | -2 | 0.691 |
MAPKAPK5 |
0.752 | -0.074 | -3 | 0.278 |
PHKG1 |
0.752 | -0.050 | -3 | 0.322 |
MEK1 |
0.752 | -0.026 | 2 | 0.837 |
HIPK2 |
0.752 | 0.003 | 1 | 0.512 |
CK1G1 |
0.752 | -0.064 | -3 | 0.165 |
PLK3 |
0.752 | -0.029 | 2 | 0.754 |
ALK2 |
0.752 | 0.019 | -2 | 0.752 |
PRP4 |
0.752 | 0.002 | -3 | 0.337 |
PKCZ |
0.751 | -0.022 | 2 | 0.806 |
CK1A2 |
0.751 | -0.043 | -3 | 0.155 |
TLK2 |
0.751 | -0.021 | 1 | 0.726 |
DCAMKL1 |
0.751 | -0.016 | -3 | 0.319 |
P38A |
0.751 | 0.021 | 1 | 0.619 |
HIPK1 |
0.751 | 0.003 | 1 | 0.615 |
PKG2 |
0.751 | -0.029 | -2 | 0.576 |
VRK2 |
0.751 | -0.022 | 1 | 0.776 |
SIK |
0.751 | -0.049 | -3 | 0.287 |
P38B |
0.751 | 0.020 | 1 | 0.552 |
PAK6 |
0.751 | -0.029 | -2 | 0.620 |
CDK12 |
0.750 | -0.002 | 1 | 0.522 |
CHK1 |
0.750 | -0.041 | -3 | 0.309 |
BRSK2 |
0.750 | -0.050 | -3 | 0.332 |
PIM2 |
0.749 | -0.032 | -3 | 0.282 |
CDK7 |
0.749 | -0.026 | 1 | 0.571 |
MST3 |
0.749 | 0.053 | 2 | 0.860 |
DYRK4 |
0.749 | 0.019 | 1 | 0.525 |
PASK |
0.749 | 0.048 | -3 | 0.320 |
CDK3 |
0.748 | 0.023 | 1 | 0.486 |
ERK1 |
0.748 | -0.000 | 1 | 0.541 |
BMPR1A |
0.748 | 0.056 | 1 | 0.777 |
GRK3 |
0.747 | 0.028 | -2 | 0.622 |
AURB |
0.747 | -0.037 | -2 | 0.551 |
CHAK1 |
0.747 | -0.072 | 2 | 0.801 |
P38G |
0.747 | 0.005 | 1 | 0.465 |
PKACA |
0.747 | -0.030 | -2 | 0.524 |
MARK2 |
0.747 | -0.016 | 4 | 0.638 |
NEK5 |
0.746 | 0.017 | 1 | 0.770 |
CDK2 |
0.746 | -0.007 | 1 | 0.642 |
DYRK1A |
0.745 | -0.023 | 1 | 0.622 |
CAMK1G |
0.745 | -0.065 | -3 | 0.278 |
HIPK3 |
0.744 | 0.007 | 1 | 0.605 |
CK2A2 |
0.744 | 0.070 | 1 | 0.701 |
IRE2 |
0.744 | -0.055 | 2 | 0.751 |
P38D |
0.743 | 0.023 | 1 | 0.461 |
CDK17 |
0.743 | -0.011 | 1 | 0.471 |
PLK4 |
0.743 | -0.047 | 2 | 0.621 |
SSTK |
0.743 | 0.044 | 4 | 0.693 |
DCAMKL2 |
0.742 | -0.035 | -3 | 0.326 |
PERK |
0.742 | -0.066 | -2 | 0.789 |
MPSK1 |
0.742 | 0.031 | 1 | 0.723 |
WNK4 |
0.742 | -0.042 | -2 | 0.849 |
AKT1 |
0.742 | -0.040 | -3 | 0.271 |
MARK1 |
0.741 | -0.039 | 4 | 0.686 |
CAMKK1 |
0.741 | 0.031 | -2 | 0.748 |
HRI |
0.741 | -0.080 | -2 | 0.804 |
AURA |
0.741 | -0.042 | -2 | 0.520 |
SNRK |
0.741 | -0.107 | 2 | 0.702 |
MEKK3 |
0.740 | -0.096 | 1 | 0.764 |
CDK16 |
0.740 | 0.019 | 1 | 0.482 |
ZAK |
0.740 | -0.051 | 1 | 0.731 |
PAK2 |
0.740 | -0.093 | -2 | 0.672 |
PKCT |
0.740 | -0.028 | 2 | 0.759 |
CK2A1 |
0.740 | 0.081 | 1 | 0.694 |
CAMK1D |
0.739 | -0.055 | -3 | 0.258 |
CDK14 |
0.739 | -0.006 | 1 | 0.562 |
TAO3 |
0.739 | -0.026 | 1 | 0.742 |
CDK10 |
0.739 | 0.000 | 1 | 0.550 |
MEK5 |
0.739 | -0.096 | 2 | 0.832 |
BRAF |
0.739 | -0.029 | -4 | 0.792 |
SMMLCK |
0.739 | -0.040 | -3 | 0.315 |
MEKK2 |
0.738 | -0.054 | 2 | 0.812 |
PKCI |
0.738 | -0.016 | 2 | 0.778 |
PKCE |
0.738 | -0.006 | 2 | 0.758 |
ERK7 |
0.738 | 0.055 | 2 | 0.622 |
MEKK1 |
0.738 | -0.066 | 1 | 0.736 |
DYRK1B |
0.738 | -0.024 | 1 | 0.559 |
AKT3 |
0.738 | -0.026 | -3 | 0.243 |
P70S6K |
0.738 | -0.073 | -3 | 0.261 |
CAMKK2 |
0.737 | 0.027 | -2 | 0.739 |
GAK |
0.737 | 0.029 | 1 | 0.796 |
ERK2 |
0.737 | -0.041 | 1 | 0.582 |
JNK1 |
0.737 | 0.013 | 1 | 0.517 |
PHKG2 |
0.737 | -0.064 | -3 | 0.317 |
NEK11 |
0.737 | -0.020 | 1 | 0.754 |
TLK1 |
0.736 | -0.072 | -2 | 0.786 |
CHK2 |
0.736 | -0.039 | -3 | 0.248 |
PKN1 |
0.736 | -0.027 | -3 | 0.289 |
BUB1 |
0.736 | 0.099 | -5 | 0.834 |
SGK1 |
0.735 | -0.038 | -3 | 0.217 |
MAK |
0.735 | 0.013 | -2 | 0.678 |
GCK |
0.734 | 0.017 | 1 | 0.776 |
DYRK3 |
0.734 | -0.046 | 1 | 0.614 |
PINK1 |
0.734 | -0.121 | 1 | 0.727 |
LKB1 |
0.734 | -0.002 | -3 | 0.354 |
IRAK4 |
0.734 | -0.062 | 1 | 0.731 |
NEK4 |
0.734 | 0.011 | 1 | 0.734 |
TNIK |
0.734 | 0.047 | 3 | 0.853 |
PLK2 |
0.733 | -0.030 | -3 | 0.257 |
EEF2K |
0.733 | 0.026 | 3 | 0.820 |
CK1A |
0.732 | -0.026 | -3 | 0.113 |
HPK1 |
0.732 | 0.037 | 1 | 0.762 |
SBK |
0.732 | -0.037 | -3 | 0.210 |
HGK |
0.732 | 0.028 | 3 | 0.847 |
MINK |
0.731 | 0.025 | 1 | 0.746 |
DAPK1 |
0.731 | -0.012 | -3 | 0.290 |
DAPK3 |
0.730 | -0.031 | -3 | 0.301 |
MST2 |
0.730 | -0.020 | 1 | 0.761 |
MEKK6 |
0.729 | 0.027 | 1 | 0.740 |
NEK1 |
0.729 | 0.008 | 1 | 0.742 |
TAO2 |
0.728 | -0.048 | 2 | 0.852 |
CAMK1A |
0.728 | -0.049 | -3 | 0.257 |
NEK8 |
0.728 | -0.096 | 2 | 0.834 |
MAP3K15 |
0.728 | 0.002 | 1 | 0.712 |
TAK1 |
0.727 | 0.004 | 1 | 0.763 |
PDK1 |
0.727 | -0.042 | 1 | 0.731 |
KHS1 |
0.727 | 0.039 | 1 | 0.728 |
TTBK1 |
0.725 | -0.122 | 2 | 0.615 |
KHS2 |
0.725 | 0.033 | 1 | 0.751 |
CDK6 |
0.724 | 0.001 | 1 | 0.533 |
IRAK1 |
0.724 | -0.128 | -1 | 0.663 |
MOK |
0.723 | -0.020 | 1 | 0.646 |
LRRK2 |
0.722 | -0.062 | 2 | 0.854 |
PAK5 |
0.721 | -0.086 | -2 | 0.542 |
VRK1 |
0.721 | -0.031 | 2 | 0.817 |
STK33 |
0.721 | -0.077 | 2 | 0.627 |
PBK |
0.720 | 0.021 | 1 | 0.718 |
LOK |
0.720 | -0.050 | -2 | 0.707 |
PAK4 |
0.720 | -0.069 | -2 | 0.542 |
MST1 |
0.719 | -0.068 | 1 | 0.744 |
YSK1 |
0.718 | -0.013 | 2 | 0.827 |
MRCKB |
0.718 | -0.068 | -3 | 0.276 |
ROCK2 |
0.717 | -0.053 | -3 | 0.303 |
CDK4 |
0.716 | -0.022 | 1 | 0.507 |
SLK |
0.716 | -0.073 | -2 | 0.656 |
PDHK3_TYR |
0.715 | 0.136 | 4 | 0.881 |
MEK2 |
0.715 | -0.086 | 2 | 0.806 |
MRCKA |
0.713 | -0.087 | -3 | 0.270 |
NEK3 |
0.713 | -0.042 | 1 | 0.688 |
BIKE |
0.712 | 0.062 | 1 | 0.691 |
RIPK2 |
0.712 | -0.148 | 1 | 0.689 |
DMPK1 |
0.711 | -0.047 | -3 | 0.283 |
HASPIN |
0.711 | -0.014 | -1 | 0.637 |
OSR1 |
0.710 | -0.037 | 2 | 0.818 |
MYO3B |
0.710 | 0.017 | 2 | 0.840 |
CRIK |
0.708 | -0.055 | -3 | 0.271 |
ASK1 |
0.707 | 0.010 | 1 | 0.696 |
BMPR2_TYR |
0.706 | 0.074 | -1 | 0.819 |
YANK3 |
0.706 | -0.051 | 2 | 0.401 |
MAP2K4_TYR |
0.705 | 0.012 | -1 | 0.815 |
PKG1 |
0.705 | -0.085 | -2 | 0.484 |
PKMYT1_TYR |
0.705 | 0.066 | 3 | 0.803 |
MAP2K6_TYR |
0.705 | 0.052 | -1 | 0.809 |
PDHK4_TYR |
0.704 | 0.001 | 2 | 0.878 |
AAK1 |
0.703 | 0.097 | 1 | 0.601 |
TESK1_TYR |
0.703 | -0.040 | 3 | 0.842 |
MYO3A |
0.702 | -0.023 | 1 | 0.719 |
TTK |
0.701 | -0.060 | -2 | 0.764 |
PDHK1_TYR |
0.701 | -0.015 | -1 | 0.817 |
ROCK1 |
0.701 | -0.076 | -3 | 0.280 |
EPHA6 |
0.700 | 0.066 | -1 | 0.791 |
MAP2K7_TYR |
0.700 | -0.118 | 2 | 0.852 |
LIMK2_TYR |
0.700 | 0.012 | -3 | 0.375 |
TXK |
0.699 | 0.123 | 1 | 0.818 |
TAO1 |
0.698 | -0.062 | 1 | 0.667 |
PINK1_TYR |
0.696 | -0.101 | 1 | 0.767 |
CK1G3 |
0.696 | -0.082 | -3 | 0.087 |
ALPHAK3 |
0.695 | -0.079 | -1 | 0.737 |
EPHB4 |
0.694 | 0.028 | -1 | 0.750 |
ABL2 |
0.691 | 0.016 | -1 | 0.764 |
FGR |
0.689 | -0.029 | 1 | 0.816 |
LIMK1_TYR |
0.689 | -0.114 | 2 | 0.846 |
EPHA4 |
0.689 | -0.000 | 2 | 0.757 |
SRMS |
0.689 | 0.027 | 1 | 0.801 |
CSF1R |
0.688 | -0.029 | 3 | 0.757 |
RET |
0.688 | -0.120 | 1 | 0.729 |
ITK |
0.688 | 0.038 | -1 | 0.748 |
TYK2 |
0.688 | -0.100 | 1 | 0.720 |
JAK2 |
0.688 | -0.066 | 1 | 0.713 |
ABL1 |
0.688 | -0.002 | -1 | 0.759 |
TYRO3 |
0.687 | -0.046 | 3 | 0.761 |
TNK2 |
0.687 | 0.012 | 3 | 0.721 |
BMX |
0.687 | 0.044 | -1 | 0.707 |
HCK |
0.687 | -0.003 | -1 | 0.790 |
STLK3 |
0.687 | -0.102 | 1 | 0.695 |
MST1R |
0.687 | -0.089 | 3 | 0.781 |
ROS1 |
0.686 | -0.058 | 3 | 0.732 |
DDR1 |
0.686 | -0.067 | 4 | 0.776 |
LCK |
0.685 | 0.012 | -1 | 0.800 |
FER |
0.685 | -0.062 | 1 | 0.796 |
INSRR |
0.684 | -0.022 | 3 | 0.715 |
BLK |
0.684 | 0.028 | -1 | 0.799 |
YES1 |
0.684 | -0.046 | -1 | 0.791 |
JAK1 |
0.684 | 0.002 | 1 | 0.681 |
EPHB1 |
0.684 | -0.004 | 1 | 0.792 |
MERTK |
0.683 | 0.021 | 3 | 0.734 |
JAK3 |
0.683 | -0.053 | 1 | 0.721 |
EPHB3 |
0.683 | -0.019 | -1 | 0.730 |
KIT |
0.682 | -0.050 | 3 | 0.759 |
NEK10_TYR |
0.681 | -0.049 | 1 | 0.622 |
TEC |
0.681 | -0.001 | -1 | 0.700 |
FYN |
0.680 | 0.009 | -1 | 0.795 |
CK1G2 |
0.680 | -0.064 | -3 | 0.125 |
EPHB2 |
0.679 | -0.029 | -1 | 0.730 |
TNNI3K_TYR |
0.679 | -0.013 | 1 | 0.718 |
PTK2B |
0.678 | 0.060 | -1 | 0.728 |
WEE1_TYR |
0.677 | -0.048 | -1 | 0.696 |
YANK2 |
0.677 | -0.063 | 2 | 0.419 |
EPHA7 |
0.676 | -0.011 | 2 | 0.760 |
AXL |
0.676 | -0.051 | 3 | 0.744 |
KDR |
0.676 | -0.075 | 3 | 0.720 |
MET |
0.675 | -0.053 | 3 | 0.754 |
TNK1 |
0.674 | -0.076 | 3 | 0.740 |
PDGFRB |
0.674 | -0.120 | 3 | 0.767 |
FGFR2 |
0.674 | -0.109 | 3 | 0.759 |
PTK2 |
0.674 | 0.056 | -1 | 0.740 |
EPHA3 |
0.673 | -0.048 | 2 | 0.732 |
FLT1 |
0.672 | -0.077 | -1 | 0.755 |
EPHA1 |
0.672 | -0.032 | 3 | 0.742 |
NTRK3 |
0.672 | -0.032 | -1 | 0.698 |
NTRK1 |
0.671 | -0.094 | -1 | 0.736 |
BTK |
0.671 | -0.117 | -1 | 0.708 |
LYN |
0.670 | -0.058 | 3 | 0.666 |
FRK |
0.670 | -0.061 | -1 | 0.787 |
PTK6 |
0.669 | -0.114 | -1 | 0.683 |
SRC |
0.669 | -0.032 | -1 | 0.783 |
ERBB2 |
0.669 | -0.111 | 1 | 0.711 |
LTK |
0.668 | -0.083 | 3 | 0.681 |
SYK |
0.668 | 0.005 | -1 | 0.736 |
FLT3 |
0.668 | -0.157 | 3 | 0.755 |
ALK |
0.668 | -0.082 | 3 | 0.664 |
DDR2 |
0.668 | -0.033 | 3 | 0.694 |
INSR |
0.668 | -0.068 | 3 | 0.698 |
FGFR1 |
0.668 | -0.124 | 3 | 0.720 |
PDGFRA |
0.668 | -0.152 | 3 | 0.763 |
MATK |
0.668 | -0.069 | -1 | 0.693 |
EPHA5 |
0.667 | -0.037 | 2 | 0.743 |
TEK |
0.667 | -0.139 | 3 | 0.696 |
EPHA8 |
0.666 | -0.041 | -1 | 0.737 |
EGFR |
0.666 | -0.054 | 1 | 0.635 |
FGFR3 |
0.666 | -0.101 | 3 | 0.736 |
NTRK2 |
0.665 | -0.107 | 3 | 0.715 |
CSK |
0.665 | -0.077 | 2 | 0.763 |
FGFR4 |
0.661 | -0.068 | -1 | 0.713 |
EPHA2 |
0.661 | -0.016 | -1 | 0.707 |
FLT4 |
0.661 | -0.139 | 3 | 0.704 |
ERBB4 |
0.657 | -0.027 | 1 | 0.667 |
IGF1R |
0.656 | -0.064 | 3 | 0.631 |
MUSK |
0.655 | -0.068 | 1 | 0.636 |
FES |
0.649 | -0.030 | -1 | 0.680 |
ZAP70 |
0.649 | -0.024 | -1 | 0.685 |