Motif 418 (n=96)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PNV4 | None | S236 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| E9PAV3 | NACA | S193 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00418 | EEF2K | S359 | psp | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O00763 | ACACB | S37 | ochoa | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}. |
| O60271 | SPAG9 | S593 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75150 | RNF40 | S525 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75891 | ALDH1L1 | S629 | ochoa | Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) | Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity). {ECO:0000250|UniProtKB:P28037, ECO:0000269|PubMed:19933275, ECO:0000269|PubMed:21238436}. |
| O94875 | SORBS2 | S1017 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95239 | KIF4A | S1013 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95490 | ADGRL2 | Y1372 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| O95721 | SNAP29 | S163 | ochoa | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| P07451 | CA3 | S227 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P08670 | VIM | S420 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P15260 | IFNGR1 | S293 | ochoa | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}. |
| P20701 | ITGAL | S1140 | ochoa | Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:29100055, ECO:0000269|PubMed:38195629}. |
| P27816 | MAP4 | S937 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P39023 | RPL3 | S265 | ochoa | Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P40925 | MDH1 | S188 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P41162 | ETV3 | S132 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P42331 | ARHGAP25 | S378 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P43403 | ZAP70 | S520 | psp | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P51610 | HCFC1 | S2007 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P52948 | NUP98 | S494 | psp | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P60484 | PTEN | S362 | psp | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P60709 | ACTB | S233 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P60842 | EIF4A1 | S205 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P62736 | ACTA2 | S235 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S233 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S234 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S235 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S235 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P82970 | HMGN5 | S20 | ochoa|psp | High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) | Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000250}. |
| Q02556 | IRF8 | S232 | ochoa | Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) | Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:P23611, ECO:0000269|PubMed:25122610, ECO:0000269|PubMed:29434592}. |
| Q08378 | GOLGA3 | S1391 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12802 | AKAP13 | S944 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13283 | G3BP1 | S39 | ochoa | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q13425 | SNTB2 | S208 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Q13554 | CAMK2B | S276 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13555 | CAMK2G | S276 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | S276 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13884 | SNTB1 | S205 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q14766 | LTBP1 | S446 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15004 | PCLAF | S88 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15149 | PLEC | S476 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15365 | PCBP1 | S86 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15652 | JMJD1C | S984 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q3L8U1 | CHD9 | S2009 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q3T8J9 | GON4L | S998 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q53ET0 | CRTC2 | S244 | psp | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q562R1 | ACTBL2 | S234 | ochoa | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
| Q5VWQ0 | RSBN1 | S91 | ochoa | Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) | Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}. |
| Q658Y4 | FAM91A1 | S347 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6DT37 | CDC42BPG | S1515 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6S8J3 | POTEE | S933 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q71RC2 | LARP4 | S569 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q7RTP6 | MICAL3 | S862 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z401 | DENND4A | S1152 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z589 | EMSY | S1102 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q86T13 | CLEC14A | S437 | ochoa | C-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5) | None |
| Q8IVL1 | NAV2 | S1120 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IXK2 | GALNT12 | S556 | ochoa | Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12) | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. |
| Q8IYL3 | C1orf174 | S182 | ochoa | UPF0688 protein C1orf174 | None |
| Q8WUI4 | HDAC7 | S487 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WUY3 | PRUNE2 | S2439 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WWN8 | ARAP3 | S1338 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Q8WYP5 | AHCTF1 | S1908 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92747 | ARPC1A | S236 | ochoa | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000305|PubMed:8978670}. |
| Q92915 | FGF14 | S228 | psp | Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4) | Probably involved in nervous system development and function. |
| Q96BY7 | ATG2B | S240 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96EY5 | MVB12A | S207 | ochoa|psp | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96GX5 | MASTL | S660 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96SN8 | CDK5RAP2 | S1666 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q9BSJ8 | ESYT1 | S627 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BYV9 | BACH2 | S719 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9BZS1 | FOXP3 | S270 | psp | Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}. |
| Q9H4G0 | EPB41L1 | S678 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H714 | RUBCNL | S189 | ochoa | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}. |
| Q9H869 | YY1AP1 | S455 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9HCP0 | CSNK1G1 | S32 | ochoa | Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}. |
| Q9NP62 | GCM1 | S178 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NQB0 | TCF7L2 | S58 | ochoa | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Q9NQS1 | AVEN | S261 | ochoa | Cell death regulator Aven | Protects against apoptosis mediated by Apaf-1. |
| Q9NW68 | BSDC1 | S79 | ochoa | BSD domain-containing protein 1 | None |
| Q9NWQ8 | PAG1 | S150 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9UEY8 | ADD3 | S442 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9ULC8 | ZDHHC8 | S526 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULG1 | INO80 | S48 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9UQ35 | SRRM2 | S2456 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y210 | TRPC6 | S839 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2H0 | DLGAP4 | S666 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| P34932 | HSPA4 | S31 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| Q02750 | MAP2K1 | S252 | SIGNOR | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| P34897 | SHMT2 | S417 | Sugiyama | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| Q99962 | SH3GL2 | S75 | SIGNOR | Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}. |
| Q9H2J4 | PDCL3 | S151 | Sugiyama | Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1) | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430). {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:17429077, ECO:0000269|PubMed:23792958, ECO:0000269|PubMed:26059764}. |
| Q9P2K8 | EIF2AK4 | S1036 | Sugiyama | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.987322e-10 | 9.525 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.471407e-07 | 6.832 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.441102e-06 | 5.841 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.509986e-06 | 5.600 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.509986e-06 | 5.600 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.509986e-06 | 5.600 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.509986e-06 | 5.600 |
| R-HSA-9764561 | Regulation of CDH1 Function | 7.177005e-06 | 5.144 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.376860e-05 | 4.861 |
| R-HSA-397014 | Muscle contraction | 3.869008e-05 | 4.412 |
| R-HSA-1474244 | Extracellular matrix organization | 3.664832e-05 | 4.436 |
| R-HSA-3371556 | Cellular response to heat stress | 4.891443e-05 | 4.311 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.261700e-05 | 4.279 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.875536e-05 | 4.052 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.149444e-04 | 3.940 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 1.029075e-04 | 3.988 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.122753e-04 | 3.950 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.420339e-04 | 3.848 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.734661e-04 | 3.761 |
| R-HSA-5673000 | RAF activation | 2.096353e-04 | 3.679 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.728969e-04 | 3.428 |
| R-HSA-913531 | Interferon Signaling | 5.455509e-04 | 3.263 |
| R-HSA-437239 | Recycling pathway of L1 | 6.301414e-04 | 3.201 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.143954e-04 | 3.146 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 9.372592e-04 | 3.028 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 9.372592e-04 | 3.028 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 9.372592e-04 | 3.028 |
| R-HSA-9620244 | Long-term potentiation | 1.390305e-03 | 2.857 |
| R-HSA-877300 | Interferon gamma signaling | 1.564235e-03 | 2.806 |
| R-HSA-196025 | Formation of annular gap junctions | 2.759243e-03 | 2.559 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.123332e-03 | 2.673 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.293690e-03 | 2.639 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.293690e-03 | 2.639 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.659278e-03 | 2.575 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.659278e-03 | 2.575 |
| R-HSA-390522 | Striated Muscle Contraction | 2.854769e-03 | 2.544 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.854769e-03 | 2.544 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 2.290717e-03 | 2.640 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.854769e-03 | 2.544 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.659278e-03 | 2.575 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.058894e-03 | 2.514 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.470647e-03 | 2.607 |
| R-HSA-373760 | L1CAM interactions | 2.251591e-03 | 2.648 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 2.759243e-03 | 2.559 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.472295e-03 | 2.607 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.817591e-03 | 2.550 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.659278e-03 | 2.575 |
| R-HSA-162582 | Signal Transduction | 2.451909e-03 | 2.610 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.344470e-03 | 2.630 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.344470e-03 | 2.630 |
| R-HSA-190873 | Gap junction degradation | 3.268897e-03 | 2.486 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.271774e-03 | 2.485 |
| R-HSA-111933 | Calmodulin induced events | 3.493526e-03 | 2.457 |
| R-HSA-111997 | CaM pathway | 3.493526e-03 | 2.457 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.213139e-03 | 2.375 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.724265e-03 | 2.429 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.724265e-03 | 2.429 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.964100e-03 | 2.402 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.213139e-03 | 2.375 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.068426e-03 | 2.391 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 4.409267e-03 | 2.356 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.471486e-03 | 2.350 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.471486e-03 | 2.350 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.471486e-03 | 2.350 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.016495e-03 | 2.300 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.739239e-03 | 2.324 |
| R-HSA-111996 | Ca-dependent events | 5.303349e-03 | 2.275 |
| R-HSA-446728 | Cell junction organization | 4.977637e-03 | 2.303 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.016495e-03 | 2.300 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.906201e-03 | 2.229 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.222371e-03 | 2.206 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.222371e-03 | 2.206 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 6.413917e-03 | 2.193 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.548477e-03 | 2.184 |
| R-HSA-75153 | Apoptotic execution phase | 6.548477e-03 | 2.184 |
| R-HSA-418990 | Adherens junctions interactions | 6.590919e-03 | 2.181 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 8.265313e-03 | 2.083 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.438966e-03 | 2.128 |
| R-HSA-3371571 | HSF1-dependent transactivation | 8.330656e-03 | 2.079 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 7.939895e-03 | 2.100 |
| R-HSA-6794361 | Neurexins and neuroligins | 8.717898e-03 | 2.060 |
| R-HSA-1500931 | Cell-Cell communication | 9.319211e-03 | 2.031 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.013261e-02 | 1.994 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.037157e-02 | 1.984 |
| R-HSA-5578775 | Ion homeostasis | 1.037157e-02 | 1.984 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.081143e-02 | 1.966 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.131306e-02 | 1.946 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.219521e-02 | 1.914 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.357805e-02 | 1.867 |
| R-HSA-191859 | snRNP Assembly | 1.172321e-02 | 1.931 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.172321e-02 | 1.931 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.267801e-02 | 1.897 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.317164e-02 | 1.880 |
| R-HSA-112043 | PLC beta mediated events | 1.267801e-02 | 1.897 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.367614e-02 | 1.864 |
| R-HSA-168255 | Influenza Infection | 1.276135e-02 | 1.894 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.419153e-02 | 1.848 |
| R-HSA-421270 | Cell-cell junction organization | 1.197235e-02 | 1.922 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.440704e-02 | 1.841 |
| R-HSA-68875 | Mitotic Prophase | 1.464165e-02 | 1.834 |
| R-HSA-112040 | G-protein mediated events | 1.580338e-02 | 1.801 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.636263e-02 | 1.786 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.655943e-02 | 1.781 |
| R-HSA-422475 | Axon guidance | 1.755395e-02 | 1.756 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 1.768388e-02 | 1.752 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.871002e-02 | 1.728 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.932454e-02 | 1.714 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 2.065140e-02 | 1.685 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 2.065140e-02 | 1.685 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.507571e-02 | 1.601 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.535493e-02 | 1.596 |
| R-HSA-6807070 | PTEN Regulation | 2.398048e-02 | 1.620 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.124440e-02 | 1.673 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.249204e-02 | 1.648 |
| R-HSA-5689603 | UCH proteinases | 2.123468e-02 | 1.673 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.350058e-02 | 1.629 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.134895e-02 | 1.671 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.464045e-02 | 1.608 |
| R-HSA-9659379 | Sensory processing of sound | 2.324480e-02 | 1.634 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.324480e-02 | 1.634 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.599020e-02 | 1.585 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.599020e-02 | 1.585 |
| R-HSA-5576891 | Cardiac conduction | 1.981418e-02 | 1.703 |
| R-HSA-9675108 | Nervous system development | 2.516169e-02 | 1.599 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.650801e-02 | 1.577 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.756494e-02 | 1.560 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.987458e-02 | 1.525 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.202922e-02 | 1.494 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.261407e-02 | 1.487 |
| R-HSA-9610379 | HCMV Late Events | 3.441087e-02 | 1.463 |
| R-HSA-162587 | HIV Life Cycle | 3.441087e-02 | 1.463 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.479112e-02 | 1.459 |
| R-HSA-109581 | Apoptosis | 3.753169e-02 | 1.426 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.807139e-02 | 1.419 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.010011e-02 | 1.397 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 4.088005e-02 | 1.388 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.113540e-02 | 1.386 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.124288e-02 | 1.385 |
| R-HSA-70171 | Glycolysis | 4.289993e-02 | 1.368 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.364701e-02 | 1.360 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 6.720877e-02 | 1.173 |
| R-HSA-8948747 | Regulation of PTEN localization | 6.720877e-02 | 1.173 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 6.720877e-02 | 1.173 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 6.720877e-02 | 1.173 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.186949e-02 | 1.285 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.186949e-02 | 1.285 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.836735e-02 | 1.234 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.280972e-02 | 1.202 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.280972e-02 | 1.202 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 6.069452e-02 | 1.217 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 5.413519e-02 | 1.267 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.678171e-02 | 1.330 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.481970e-02 | 1.349 |
| R-HSA-68886 | M Phase | 6.293367e-02 | 1.201 |
| R-HSA-190828 | Gap junction trafficking | 5.131995e-02 | 1.290 |
| R-HSA-202403 | TCR signaling | 5.397683e-02 | 1.268 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.031581e-02 | 1.220 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.395843e-02 | 1.194 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.054174e-02 | 1.218 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 5.665559e-02 | 1.247 |
| R-HSA-111885 | Opioid Signalling | 4.678171e-02 | 1.330 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.031581e-02 | 1.220 |
| R-HSA-70326 | Glucose metabolism | 6.395843e-02 | 1.194 |
| R-HSA-983712 | Ion channel transport | 5.792905e-02 | 1.237 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.847563e-02 | 1.233 |
| R-HSA-211000 | Gene Silencing by RNA | 5.083122e-02 | 1.294 |
| R-HSA-2262752 | Cellular responses to stress | 5.787922e-02 | 1.237 |
| R-HSA-445355 | Smooth Muscle Contraction | 6.787074e-02 | 1.168 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.226906e-02 | 1.141 |
| R-HSA-5357801 | Programmed Cell Death | 7.270118e-02 | 1.138 |
| R-HSA-446107 | Type I hemidesmosome assembly | 7.367823e-02 | 1.133 |
| R-HSA-177929 | Signaling by EGFR | 7.373108e-02 | 1.132 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 8.648406e-02 | 1.063 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 8.648406e-02 | 1.063 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.053645e-01 | 0.977 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.299381e-01 | 0.886 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.395657e-01 | 0.855 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.395657e-01 | 0.855 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.539189e-01 | 0.813 |
| R-HSA-156902 | Peptide chain elongation | 1.467053e-01 | 0.834 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 8.010323e-02 | 1.096 |
| R-HSA-4641265 | Repression of WNT target genes | 1.053645e-01 | 0.977 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.177361e-01 | 0.929 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.053645e-01 | 0.977 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.115717e-01 | 0.952 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.115717e-01 | 0.952 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.479283e-01 | 0.830 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.177361e-01 | 0.929 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 8.648406e-02 | 1.063 |
| R-HSA-170968 | Frs2-mediated activation | 1.115717e-01 | 0.952 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.053645e-01 | 0.977 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 1.115717e-01 | 0.952 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.238582e-01 | 0.907 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.255337e-01 | 0.901 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 9.846945e-02 | 1.007 |
| R-HSA-9664417 | Leishmania phagocytosis | 9.707802e-02 | 1.013 |
| R-HSA-9664407 | Parasite infection | 9.707802e-02 | 1.013 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 9.707802e-02 | 1.013 |
| R-HSA-169893 | Prolonged ERK activation events | 1.299381e-01 | 0.886 |
| R-HSA-111458 | Formation of apoptosome | 8.648406e-02 | 1.063 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.177361e-01 | 0.929 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.238582e-01 | 0.907 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.419729e-01 | 0.848 |
| R-HSA-9609646 | HCMV Infection | 1.199341e-01 | 0.921 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 8.648406e-02 | 1.063 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 9.911441e-02 | 1.004 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.177361e-01 | 0.929 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.929284e-02 | 1.101 |
| R-HSA-8953854 | Metabolism of RNA | 1.422702e-01 | 0.847 |
| R-HSA-196780 | Biotin transport and metabolism | 1.238582e-01 | 0.907 |
| R-HSA-199991 | Membrane Trafficking | 9.525955e-02 | 1.021 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.177361e-01 | 0.929 |
| R-HSA-9711097 | Cellular response to starvation | 1.248404e-01 | 0.904 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.518111e-01 | 0.819 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.096396e-01 | 0.960 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.177361e-01 | 0.929 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.534527e-01 | 0.814 |
| R-HSA-8963896 | HDL assembly | 1.177361e-01 | 0.929 |
| R-HSA-112316 | Neuronal System | 1.264563e-01 | 0.898 |
| R-HSA-180292 | GAB1 signalosome | 1.479283e-01 | 0.830 |
| R-HSA-5688426 | Deubiquitination | 1.258515e-01 | 0.900 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.355718e-01 | 0.868 |
| R-HSA-9707616 | Heme signaling | 8.591167e-02 | 1.066 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.479283e-01 | 0.830 |
| R-HSA-162906 | HIV Infection | 9.438209e-02 | 1.025 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 1.419729e-01 | 0.848 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.118757e-01 | 0.951 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.348501e-01 | 0.870 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 8.178637e-02 | 1.087 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 8.178637e-02 | 1.087 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 8.178637e-02 | 1.087 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 8.178637e-02 | 1.087 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.543359e-02 | 1.020 |
| R-HSA-74160 | Gene expression (Transcription) | 1.470417e-01 | 0.833 |
| R-HSA-168256 | Immune System | 1.051174e-01 | 0.978 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 8.178637e-02 | 1.087 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.163834e-01 | 0.934 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.117936e-01 | 0.952 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.155571e-01 | 0.937 |
| R-HSA-72306 | tRNA processing | 1.453030e-01 | 0.838 |
| R-HSA-5619102 | SLC transporter disorders | 1.388913e-01 | 0.857 |
| R-HSA-157118 | Signaling by NOTCH | 1.084795e-01 | 0.965 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.563389e-01 | 0.806 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.587662e-01 | 0.799 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.597163e-01 | 0.797 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.597163e-01 | 0.797 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.597163e-01 | 0.797 |
| R-HSA-445144 | Signal transduction by L1 | 1.597163e-01 | 0.797 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.660899e-01 | 0.780 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.685444e-01 | 0.773 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.685444e-01 | 0.773 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.685444e-01 | 0.773 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.713428e-01 | 0.766 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.713428e-01 | 0.766 |
| R-HSA-175474 | Assembly Of The HIV Virion | 1.713428e-01 | 0.766 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.770961e-01 | 0.752 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.770961e-01 | 0.752 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.772789e-01 | 0.751 |
| R-HSA-3214847 | HATs acetylate histones | 1.784233e-01 | 0.749 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.809072e-01 | 0.743 |
| R-HSA-1643685 | Disease | 1.817718e-01 | 0.740 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.828098e-01 | 0.738 |
| R-HSA-200425 | Carnitine shuttle | 1.828098e-01 | 0.738 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.833965e-01 | 0.737 |
| R-HSA-68877 | Mitotic Prometaphase | 1.839078e-01 | 0.735 |
| R-HSA-1483255 | PI Metabolism | 1.858908e-01 | 0.731 |
| R-HSA-192823 | Viral mRNA Translation | 1.883901e-01 | 0.725 |
| R-HSA-429947 | Deadenylation of mRNA | 1.884842e-01 | 0.725 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 1.884842e-01 | 0.725 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 1.884842e-01 | 0.725 |
| R-HSA-9609690 | HCMV Early Events | 1.891350e-01 | 0.723 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.941195e-01 | 0.712 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.941195e-01 | 0.712 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.959155e-01 | 0.708 |
| R-HSA-525793 | Myogenesis | 1.997160e-01 | 0.700 |
| R-HSA-3295583 | TRP channels | 1.997160e-01 | 0.700 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.997160e-01 | 0.700 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.009538e-01 | 0.697 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.009538e-01 | 0.697 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.009538e-01 | 0.697 |
| R-HSA-1266738 | Developmental Biology | 2.048679e-01 | 0.689 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.052741e-01 | 0.688 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.060073e-01 | 0.686 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.125274e-01 | 0.673 |
| R-HSA-9679506 | SARS-CoV Infections | 2.129645e-01 | 0.672 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.136135e-01 | 0.670 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.136135e-01 | 0.670 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.162756e-01 | 0.665 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.162756e-01 | 0.665 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.162756e-01 | 0.665 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.168872e-01 | 0.664 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.200870e-01 | 0.657 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.217196e-01 | 0.654 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.251688e-01 | 0.647 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.263484e-01 | 0.645 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.263484e-01 | 0.645 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.271262e-01 | 0.644 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.271262e-01 | 0.644 |
| R-HSA-182971 | EGFR downregulation | 2.271262e-01 | 0.644 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.271262e-01 | 0.644 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.324955e-01 | 0.634 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.378278e-01 | 0.624 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.417016e-01 | 0.617 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.431235e-01 | 0.614 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 2.431235e-01 | 0.614 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.468315e-01 | 0.608 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.483826e-01 | 0.605 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 2.525030e-01 | 0.598 |
| R-HSA-187687 | Signalling to ERKs | 2.536056e-01 | 0.596 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.536056e-01 | 0.596 |
| R-HSA-194138 | Signaling by VEGF | 2.545340e-01 | 0.594 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.587925e-01 | 0.587 |
| R-HSA-9845576 | Glycosphingolipid transport | 2.587925e-01 | 0.587 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.622422e-01 | 0.581 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.639438e-01 | 0.578 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.639438e-01 | 0.578 |
| R-HSA-1566948 | Elastic fibre formation | 2.690596e-01 | 0.570 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 2.741401e-01 | 0.562 |
| R-HSA-9909396 | Circadian clock | 2.750929e-01 | 0.561 |
| R-HSA-202433 | Generation of second messenger molecules | 2.791856e-01 | 0.554 |
| R-HSA-9646399 | Aggrephagy | 2.791856e-01 | 0.554 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.841964e-01 | 0.546 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.841964e-01 | 0.546 |
| R-HSA-9694548 | Maturation of spike protein | 2.841964e-01 | 0.546 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.841964e-01 | 0.546 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.843683e-01 | 0.546 |
| R-HSA-163685 | Integration of energy metabolism | 2.879348e-01 | 0.541 |
| R-HSA-6811438 | Intra-Golgi traffic | 2.891726e-01 | 0.539 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.891726e-01 | 0.539 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.930659e-01 | 0.533 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 2.941146e-01 | 0.531 |
| R-HSA-165159 | MTOR signalling | 2.941146e-01 | 0.531 |
| R-HSA-212436 | Generic Transcription Pathway | 2.986439e-01 | 0.525 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.990224e-01 | 0.524 |
| R-HSA-5663205 | Infectious disease | 3.020002e-01 | 0.520 |
| R-HSA-373752 | Netrin-1 signaling | 3.038965e-01 | 0.517 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.087370e-01 | 0.510 |
| R-HSA-166520 | Signaling by NTRKs | 3.211829e-01 | 0.493 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.262698e-01 | 0.486 |
| R-HSA-73893 | DNA Damage Bypass | 3.277676e-01 | 0.484 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.313470e-01 | 0.480 |
| R-HSA-9612973 | Autophagy | 3.414696e-01 | 0.467 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.416990e-01 | 0.466 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.416990e-01 | 0.466 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.462788e-01 | 0.461 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.462788e-01 | 0.461 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.462788e-01 | 0.461 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.488512e-01 | 0.457 |
| R-HSA-9658195 | Leishmania infection | 3.488512e-01 | 0.457 |
| R-HSA-72649 | Translation initiation complex formation | 3.508272e-01 | 0.455 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.598299e-01 | 0.444 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.598299e-01 | 0.444 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.598299e-01 | 0.444 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.615695e-01 | 0.442 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.615695e-01 | 0.442 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.687089e-01 | 0.433 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.687089e-01 | 0.433 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.731025e-01 | 0.428 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.731025e-01 | 0.428 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.774658e-01 | 0.423 |
| R-HSA-983189 | Kinesins | 3.774658e-01 | 0.423 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.789728e-01 | 0.421 |
| R-HSA-450294 | MAP kinase activation | 3.817990e-01 | 0.418 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.861024e-01 | 0.413 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.903760e-01 | 0.409 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.903760e-01 | 0.409 |
| R-HSA-1640170 | Cell Cycle | 3.966414e-01 | 0.402 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.030208e-01 | 0.395 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.030208e-01 | 0.395 |
| R-HSA-9824446 | Viral Infection Pathways | 4.051582e-01 | 0.392 |
| R-HSA-913709 | O-linked glycosylation of mucins | 4.113058e-01 | 0.386 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.152280e-01 | 0.382 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.194769e-01 | 0.377 |
| R-HSA-448424 | Interleukin-17 signaling | 4.194769e-01 | 0.377 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.227744e-01 | 0.374 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.235203e-01 | 0.373 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.235203e-01 | 0.373 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.275356e-01 | 0.369 |
| R-HSA-8957322 | Metabolism of steroids | 4.294617e-01 | 0.367 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.315233e-01 | 0.365 |
| R-HSA-4086398 | Ca2+ pathway | 4.315233e-01 | 0.365 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.315233e-01 | 0.365 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.322988e-01 | 0.364 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.370301e-01 | 0.359 |
| R-HSA-380287 | Centrosome maturation | 4.394162e-01 | 0.357 |
| R-HSA-8852135 | Protein ubiquitination | 4.394162e-01 | 0.357 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.472006e-01 | 0.349 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.510524e-01 | 0.346 |
| R-HSA-216083 | Integrin cell surface interactions | 4.510524e-01 | 0.346 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.510965e-01 | 0.346 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.522260e-01 | 0.345 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.580560e-01 | 0.339 |
| R-HSA-6806834 | Signaling by MET | 4.586766e-01 | 0.338 |
| R-HSA-72172 | mRNA Splicing | 4.626678e-01 | 0.335 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.699165e-01 | 0.328 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.736114e-01 | 0.325 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.809250e-01 | 0.318 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.831368e-01 | 0.316 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.881378e-01 | 0.311 |
| R-HSA-68882 | Mitotic Anaphase | 4.898540e-01 | 0.310 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.917069e-01 | 0.308 |
| R-HSA-9663891 | Selective autophagy | 4.917069e-01 | 0.308 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.920811e-01 | 0.308 |
| R-HSA-73894 | DNA Repair | 4.942151e-01 | 0.306 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.987712e-01 | 0.302 |
| R-HSA-202424 | Downstream TCR signaling | 4.987712e-01 | 0.302 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 5.011953e-01 | 0.300 |
| R-HSA-391251 | Protein folding | 5.091857e-01 | 0.293 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.091857e-01 | 0.293 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.091857e-01 | 0.293 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.118505e-01 | 0.291 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.160092e-01 | 0.287 |
| R-HSA-1474290 | Collagen formation | 5.160092e-01 | 0.287 |
| R-HSA-72312 | rRNA processing | 5.247508e-01 | 0.280 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.260686e-01 | 0.279 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.260686e-01 | 0.279 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.290004e-01 | 0.277 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.293755e-01 | 0.276 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.326595e-01 | 0.274 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.326595e-01 | 0.274 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.326595e-01 | 0.274 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.326595e-01 | 0.274 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.359207e-01 | 0.271 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.423758e-01 | 0.266 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.455699e-01 | 0.263 |
| R-HSA-382551 | Transport of small molecules | 5.503565e-01 | 0.259 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.518919e-01 | 0.258 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.581267e-01 | 0.253 |
| R-HSA-4839726 | Chromatin organization | 5.600542e-01 | 0.252 |
| R-HSA-418346 | Platelet homeostasis | 5.612118e-01 | 0.251 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.673181e-01 | 0.246 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.673181e-01 | 0.246 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.703396e-01 | 0.244 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.733402e-01 | 0.242 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.733402e-01 | 0.242 |
| R-HSA-418594 | G alpha (i) signalling events | 5.745731e-01 | 0.241 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.779836e-01 | 0.238 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.822179e-01 | 0.235 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.880344e-01 | 0.231 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.909124e-01 | 0.228 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.994277e-01 | 0.222 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.994277e-01 | 0.222 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.022268e-01 | 0.220 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.050066e-01 | 0.218 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.050066e-01 | 0.218 |
| R-HSA-72766 | Translation | 6.086957e-01 | 0.216 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.132310e-01 | 0.212 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.132310e-01 | 0.212 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.159346e-01 | 0.210 |
| R-HSA-1280218 | Adaptive Immune System | 6.177889e-01 | 0.209 |
| R-HSA-597592 | Post-translational protein modification | 6.292053e-01 | 0.201 |
| R-HSA-392499 | Metabolism of proteins | 6.340540e-01 | 0.198 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.368995e-01 | 0.196 |
| R-HSA-9843745 | Adipogenesis | 6.419610e-01 | 0.192 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.444655e-01 | 0.191 |
| R-HSA-1483257 | Phospholipid metabolism | 6.460857e-01 | 0.190 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.466490e-01 | 0.189 |
| R-HSA-6798695 | Neutrophil degranulation | 6.494598e-01 | 0.187 |
| R-HSA-388396 | GPCR downstream signalling | 6.530424e-01 | 0.185 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.567297e-01 | 0.183 |
| R-HSA-5173105 | O-linked glycosylation | 6.591318e-01 | 0.181 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.605461e-01 | 0.180 |
| R-HSA-109582 | Hemostasis | 6.639182e-01 | 0.178 |
| R-HSA-1632852 | Macroautophagy | 6.685746e-01 | 0.175 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.866892e-01 | 0.163 |
| R-HSA-9758941 | Gastrulation | 6.888834e-01 | 0.162 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.910624e-01 | 0.160 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.916913e-01 | 0.160 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.953750e-01 | 0.158 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.996280e-01 | 0.155 |
| R-HSA-73887 | Death Receptor Signaling | 6.996280e-01 | 0.155 |
| R-HSA-1989781 | PPARA activates gene expression | 7.017324e-01 | 0.154 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.058974e-01 | 0.151 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.120371e-01 | 0.147 |
| R-HSA-372790 | Signaling by GPCR | 7.365882e-01 | 0.133 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.372072e-01 | 0.132 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.390505e-01 | 0.131 |
| R-HSA-611105 | Respiratory electron transport | 7.480765e-01 | 0.126 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.567929e-01 | 0.121 |
| R-HSA-3781865 | Diseases of glycosylation | 7.585000e-01 | 0.120 |
| R-HSA-69275 | G2/M Transition | 7.618786e-01 | 0.118 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.652104e-01 | 0.116 |
| R-HSA-5617833 | Cilium Assembly | 7.684960e-01 | 0.114 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.701216e-01 | 0.113 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.826376e-01 | 0.106 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.842526e-01 | 0.106 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.254215e-01 | 0.083 |
| R-HSA-449147 | Signaling by Interleukins | 8.313634e-01 | 0.080 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.350166e-01 | 0.078 |
| R-HSA-168249 | Innate Immune System | 8.381169e-01 | 0.077 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.557610e-01 | 0.068 |
| R-HSA-416476 | G alpha (q) signalling events | 8.637018e-01 | 0.064 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.675081e-01 | 0.062 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.730210e-01 | 0.059 |
| R-HSA-195721 | Signaling by WNT | 8.928893e-01 | 0.049 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.210869e-01 | 0.036 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.396270e-01 | 0.027 |
| R-HSA-8978868 | Fatty acid metabolism | 9.510577e-01 | 0.022 |
| R-HSA-5668914 | Diseases of metabolism | 9.575788e-01 | 0.019 |
| R-HSA-556833 | Metabolism of lipids | 9.829635e-01 | 0.007 |
| R-HSA-9709957 | Sensory Perception | 9.939073e-01 | 0.003 |
| R-HSA-1430728 | Metabolism | 9.987348e-01 | 0.001 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.822 | 0.222 | 1 | 0.837 |
COT |
0.819 | 0.159 | 2 | 0.791 |
CDC7 |
0.814 | 0.081 | 1 | 0.846 |
NDR2 |
0.811 | 0.081 | -3 | 0.832 |
RSK2 |
0.810 | 0.123 | -3 | 0.782 |
PRKD2 |
0.810 | 0.146 | -3 | 0.812 |
SKMLCK |
0.809 | 0.191 | -2 | 0.803 |
PRKD1 |
0.809 | 0.109 | -3 | 0.841 |
CAMK1B |
0.809 | 0.119 | -3 | 0.860 |
SRPK1 |
0.808 | 0.138 | -3 | 0.756 |
NUAK2 |
0.808 | 0.134 | -3 | 0.845 |
CLK1 |
0.807 | 0.203 | -3 | 0.791 |
P90RSK |
0.806 | 0.090 | -3 | 0.780 |
MOS |
0.806 | 0.113 | 1 | 0.833 |
MAPKAPK3 |
0.805 | 0.101 | -3 | 0.805 |
CAMK2D |
0.805 | 0.082 | -3 | 0.838 |
WNK1 |
0.804 | 0.139 | -2 | 0.828 |
MAPKAPK2 |
0.804 | 0.097 | -3 | 0.763 |
NLK |
0.804 | 0.099 | 1 | 0.817 |
AURC |
0.803 | 0.133 | -2 | 0.609 |
PRPK |
0.803 | -0.065 | -1 | 0.689 |
NDR1 |
0.802 | 0.082 | -3 | 0.837 |
CLK4 |
0.802 | 0.161 | -3 | 0.787 |
HIPK4 |
0.802 | 0.104 | 1 | 0.759 |
CAMK2A |
0.802 | 0.131 | 2 | 0.728 |
CLK2 |
0.802 | 0.210 | -3 | 0.770 |
ERK5 |
0.802 | 0.068 | 1 | 0.782 |
PIM3 |
0.801 | 0.033 | -3 | 0.821 |
CDKL1 |
0.801 | 0.062 | -3 | 0.789 |
RAF1 |
0.801 | -0.009 | 1 | 0.771 |
CAMK2B |
0.800 | 0.106 | 2 | 0.717 |
TSSK1 |
0.800 | 0.141 | -3 | 0.869 |
AMPKA1 |
0.800 | 0.111 | -3 | 0.858 |
RIPK3 |
0.800 | 0.107 | 3 | 0.779 |
MST4 |
0.800 | 0.083 | 2 | 0.720 |
MTOR |
0.799 | -0.067 | 1 | 0.744 |
CAMK2G |
0.799 | -0.004 | 2 | 0.723 |
LATS2 |
0.799 | 0.055 | -5 | 0.688 |
TSSK2 |
0.798 | 0.125 | -5 | 0.864 |
RSK3 |
0.798 | 0.063 | -3 | 0.784 |
DYRK2 |
0.798 | 0.147 | 1 | 0.716 |
DAPK2 |
0.798 | 0.118 | -3 | 0.851 |
CAMLCK |
0.797 | 0.077 | -2 | 0.785 |
AMPKA2 |
0.797 | 0.099 | -3 | 0.838 |
SRPK2 |
0.796 | 0.096 | -3 | 0.689 |
PKACG |
0.796 | 0.086 | -2 | 0.698 |
IKKB |
0.796 | -0.079 | -2 | 0.688 |
PKN2 |
0.796 | 0.082 | -3 | 0.850 |
PIM1 |
0.796 | 0.078 | -3 | 0.788 |
PKN3 |
0.796 | 0.026 | -3 | 0.830 |
HUNK |
0.796 | 0.041 | 2 | 0.760 |
MNK2 |
0.796 | 0.112 | -2 | 0.751 |
NIK |
0.795 | 0.079 | -3 | 0.869 |
PDHK4 |
0.795 | -0.199 | 1 | 0.789 |
BMPR2 |
0.795 | -0.106 | -2 | 0.820 |
CDKL5 |
0.795 | 0.054 | -3 | 0.782 |
GCN2 |
0.795 | -0.154 | 2 | 0.698 |
DSTYK |
0.795 | -0.047 | 2 | 0.777 |
MSK1 |
0.795 | 0.090 | -3 | 0.757 |
NUAK1 |
0.794 | 0.081 | -3 | 0.821 |
P70S6KB |
0.794 | 0.064 | -3 | 0.810 |
MARK4 |
0.794 | 0.019 | 4 | 0.756 |
RSK4 |
0.793 | 0.104 | -3 | 0.749 |
GRK6 |
0.793 | 0.048 | 1 | 0.832 |
PRKD3 |
0.793 | 0.101 | -3 | 0.796 |
ICK |
0.793 | 0.067 | -3 | 0.825 |
MYLK4 |
0.793 | 0.100 | -2 | 0.714 |
TGFBR2 |
0.793 | -0.022 | -2 | 0.723 |
KIS |
0.792 | 0.069 | 1 | 0.708 |
ATR |
0.792 | -0.052 | 1 | 0.761 |
GRK1 |
0.792 | 0.079 | -2 | 0.689 |
ULK2 |
0.791 | -0.108 | 2 | 0.669 |
CAMK4 |
0.791 | 0.042 | -3 | 0.839 |
CDK7 |
0.791 | 0.092 | 1 | 0.705 |
BMPR1B |
0.791 | 0.153 | 1 | 0.852 |
JNK2 |
0.791 | 0.152 | 1 | 0.665 |
CHK1 |
0.791 | 0.090 | -3 | 0.833 |
CDK8 |
0.791 | 0.067 | 1 | 0.704 |
TBK1 |
0.791 | -0.123 | 1 | 0.653 |
MNK1 |
0.791 | 0.126 | -2 | 0.762 |
GRK5 |
0.790 | -0.061 | -3 | 0.791 |
MSK2 |
0.790 | 0.036 | -3 | 0.745 |
SRPK3 |
0.790 | 0.072 | -3 | 0.724 |
PKACB |
0.789 | 0.100 | -2 | 0.637 |
MELK |
0.789 | 0.079 | -3 | 0.833 |
CDK19 |
0.789 | 0.077 | 1 | 0.672 |
PRKX |
0.789 | 0.135 | -3 | 0.714 |
CDK18 |
0.789 | 0.133 | 1 | 0.644 |
PAK6 |
0.788 | 0.084 | -2 | 0.636 |
DYRK4 |
0.788 | 0.163 | 1 | 0.663 |
PKCD |
0.788 | 0.035 | 2 | 0.647 |
AURB |
0.788 | 0.084 | -2 | 0.600 |
RIPK1 |
0.788 | -0.012 | 1 | 0.729 |
IKKE |
0.788 | -0.128 | 1 | 0.650 |
TGFBR1 |
0.788 | 0.077 | -2 | 0.740 |
CHAK2 |
0.788 | -0.018 | -1 | 0.749 |
HIPK1 |
0.787 | 0.166 | 1 | 0.722 |
NIM1 |
0.787 | -0.006 | 3 | 0.769 |
BCKDK |
0.787 | -0.119 | -1 | 0.671 |
ATM |
0.787 | -0.016 | 1 | 0.703 |
PDHK1 |
0.787 | -0.228 | 1 | 0.758 |
BRSK1 |
0.786 | 0.050 | -3 | 0.821 |
PAK1 |
0.786 | 0.044 | -2 | 0.711 |
SIK |
0.786 | 0.050 | -3 | 0.799 |
QSK |
0.786 | 0.046 | 4 | 0.717 |
WNK3 |
0.786 | -0.085 | 1 | 0.730 |
HIPK2 |
0.785 | 0.147 | 1 | 0.638 |
PKG2 |
0.785 | 0.088 | -2 | 0.645 |
IKKA |
0.785 | -0.064 | -2 | 0.680 |
NEK6 |
0.785 | -0.101 | -2 | 0.806 |
DCAMKL1 |
0.785 | 0.123 | -3 | 0.827 |
NEK7 |
0.785 | -0.137 | -3 | 0.771 |
ULK1 |
0.785 | -0.107 | -3 | 0.790 |
QIK |
0.784 | 0.023 | -3 | 0.830 |
SGK3 |
0.784 | 0.100 | -3 | 0.781 |
PAK3 |
0.784 | 0.019 | -2 | 0.718 |
AKT2 |
0.783 | 0.081 | -3 | 0.719 |
JNK3 |
0.783 | 0.117 | 1 | 0.691 |
FAM20C |
0.783 | -0.011 | 2 | 0.513 |
MASTL |
0.783 | -0.151 | -2 | 0.750 |
DLK |
0.783 | -0.039 | 1 | 0.801 |
DRAK1 |
0.783 | 0.119 | 1 | 0.797 |
ALK4 |
0.783 | 0.035 | -2 | 0.763 |
LATS1 |
0.783 | 0.049 | -3 | 0.827 |
PLK1 |
0.782 | 0.032 | -2 | 0.762 |
ACVR2B |
0.782 | 0.093 | -2 | 0.733 |
NEK9 |
0.782 | -0.097 | 2 | 0.715 |
MLK1 |
0.782 | -0.112 | 2 | 0.681 |
CDK17 |
0.781 | 0.111 | 1 | 0.611 |
MAPKAPK5 |
0.781 | -0.001 | -3 | 0.722 |
MARK3 |
0.781 | 0.047 | 4 | 0.679 |
DYRK1B |
0.781 | 0.139 | 1 | 0.686 |
PKCB |
0.781 | 0.039 | 2 | 0.590 |
BRSK2 |
0.780 | 0.006 | -3 | 0.839 |
PKCG |
0.780 | 0.043 | 2 | 0.585 |
P38A |
0.780 | 0.091 | 1 | 0.718 |
PKACA |
0.780 | 0.084 | -2 | 0.595 |
ANKRD3 |
0.780 | -0.056 | 1 | 0.776 |
GRK4 |
0.780 | -0.108 | -2 | 0.737 |
CAMK1G |
0.780 | 0.054 | -3 | 0.787 |
PHKG1 |
0.779 | 0.005 | -3 | 0.836 |
ACVR2A |
0.779 | 0.060 | -2 | 0.720 |
DCAMKL2 |
0.779 | 0.084 | -3 | 0.850 |
DYRK1A |
0.779 | 0.099 | 1 | 0.745 |
MARK2 |
0.778 | 0.015 | 4 | 0.648 |
CDK13 |
0.778 | 0.055 | 1 | 0.677 |
CDK14 |
0.778 | 0.129 | 1 | 0.676 |
SMMLCK |
0.777 | 0.094 | -3 | 0.824 |
PKR |
0.777 | 0.018 | 1 | 0.753 |
HIPK3 |
0.777 | 0.124 | 1 | 0.711 |
CDK9 |
0.777 | 0.064 | 1 | 0.683 |
P38B |
0.776 | 0.089 | 1 | 0.674 |
DYRK3 |
0.776 | 0.115 | 1 | 0.717 |
ALK2 |
0.776 | 0.030 | -2 | 0.734 |
MEK1 |
0.776 | -0.063 | 2 | 0.736 |
PKCH |
0.776 | 0.010 | 2 | 0.576 |
DNAPK |
0.776 | -0.013 | 1 | 0.616 |
IRE1 |
0.775 | -0.071 | 1 | 0.691 |
CAMK1D |
0.775 | 0.081 | -3 | 0.730 |
CDK10 |
0.775 | 0.127 | 1 | 0.664 |
MLK2 |
0.775 | -0.112 | 2 | 0.689 |
CDK1 |
0.775 | 0.071 | 1 | 0.692 |
PKCA |
0.775 | -0.000 | 2 | 0.579 |
P38G |
0.774 | 0.098 | 1 | 0.611 |
SSTK |
0.774 | 0.106 | 4 | 0.710 |
MARK1 |
0.774 | 0.016 | 4 | 0.696 |
ERK1 |
0.774 | 0.078 | 1 | 0.657 |
PASK |
0.774 | 0.108 | -3 | 0.818 |
CDK5 |
0.774 | 0.064 | 1 | 0.717 |
GRK2 |
0.774 | 0.035 | -2 | 0.626 |
CDK12 |
0.774 | 0.070 | 1 | 0.658 |
BMPR1A |
0.773 | 0.095 | 1 | 0.835 |
AURA |
0.773 | 0.001 | -2 | 0.560 |
TTBK2 |
0.773 | -0.151 | 2 | 0.577 |
PKCZ |
0.773 | -0.004 | 2 | 0.641 |
ERK2 |
0.773 | 0.063 | 1 | 0.700 |
PAK2 |
0.773 | -0.025 | -2 | 0.688 |
SMG1 |
0.772 | -0.078 | 1 | 0.699 |
GRK7 |
0.772 | 0.006 | 1 | 0.757 |
PIM2 |
0.772 | 0.036 | -3 | 0.770 |
GSK3B |
0.772 | 0.083 | 4 | 0.544 |
WNK4 |
0.771 | 0.040 | -2 | 0.809 |
CDK16 |
0.771 | 0.115 | 1 | 0.619 |
BRAF |
0.771 | 0.004 | -4 | 0.747 |
VRK2 |
0.771 | -0.129 | 1 | 0.807 |
AKT1 |
0.770 | 0.064 | -3 | 0.739 |
NEK2 |
0.770 | -0.074 | 2 | 0.673 |
DAPK3 |
0.770 | 0.116 | -3 | 0.817 |
PLK3 |
0.770 | -0.076 | 2 | 0.696 |
YSK4 |
0.770 | -0.113 | 1 | 0.701 |
PRP4 |
0.768 | 0.026 | -3 | 0.689 |
GSK3A |
0.768 | 0.091 | 4 | 0.555 |
PAK5 |
0.768 | 0.037 | -2 | 0.552 |
SBK |
0.768 | 0.087 | -3 | 0.625 |
P38D |
0.768 | 0.100 | 1 | 0.600 |
DAPK1 |
0.768 | 0.111 | -3 | 0.793 |
CDK2 |
0.767 | 0.008 | 1 | 0.759 |
PLK4 |
0.767 | -0.053 | 2 | 0.533 |
PHKG2 |
0.767 | 0.019 | -3 | 0.848 |
PAK4 |
0.767 | 0.044 | -2 | 0.560 |
P70S6K |
0.766 | 0.004 | -3 | 0.732 |
SNRK |
0.766 | -0.100 | 2 | 0.569 |
MST3 |
0.766 | 0.040 | 2 | 0.709 |
MLK3 |
0.766 | -0.103 | 2 | 0.587 |
CHK2 |
0.766 | 0.073 | -3 | 0.692 |
CHAK1 |
0.764 | -0.123 | 2 | 0.630 |
TLK2 |
0.764 | -0.132 | 1 | 0.713 |
CDK3 |
0.764 | 0.065 | 1 | 0.627 |
IRAK4 |
0.764 | -0.005 | 1 | 0.698 |
PKCT |
0.764 | 0.002 | 2 | 0.585 |
IRE2 |
0.764 | -0.115 | 2 | 0.609 |
CAMK1A |
0.764 | 0.064 | -3 | 0.726 |
MEKK3 |
0.763 | -0.075 | 1 | 0.749 |
JNK1 |
0.763 | 0.087 | 1 | 0.664 |
MLK4 |
0.762 | -0.105 | 2 | 0.583 |
CK1E |
0.762 | -0.020 | -3 | 0.459 |
GAK |
0.762 | 0.050 | 1 | 0.754 |
SGK1 |
0.762 | 0.075 | -3 | 0.639 |
CK2A2 |
0.762 | 0.062 | 1 | 0.770 |
IRAK1 |
0.761 | -0.084 | -1 | 0.660 |
MEK5 |
0.761 | -0.143 | 2 | 0.707 |
AKT3 |
0.760 | 0.064 | -3 | 0.660 |
MAK |
0.760 | 0.116 | -2 | 0.661 |
PKCI |
0.760 | 0.005 | 2 | 0.600 |
GRK3 |
0.760 | 0.014 | -2 | 0.574 |
PKCE |
0.759 | 0.039 | 2 | 0.569 |
ZAK |
0.759 | -0.116 | 1 | 0.727 |
PERK |
0.759 | -0.157 | -2 | 0.757 |
HRI |
0.759 | -0.180 | -2 | 0.780 |
PKN1 |
0.759 | 0.020 | -3 | 0.756 |
TAO3 |
0.758 | -0.041 | 1 | 0.734 |
MRCKB |
0.758 | 0.078 | -3 | 0.778 |
MEKK1 |
0.758 | -0.131 | 1 | 0.732 |
MOK |
0.757 | 0.121 | 1 | 0.711 |
TLK1 |
0.757 | -0.133 | -2 | 0.768 |
NEK5 |
0.757 | -0.075 | 1 | 0.734 |
DMPK1 |
0.757 | 0.137 | -3 | 0.801 |
NEK11 |
0.756 | -0.056 | 1 | 0.727 |
MEKK2 |
0.755 | -0.119 | 2 | 0.681 |
MRCKA |
0.755 | 0.058 | -3 | 0.784 |
ROCK2 |
0.755 | 0.104 | -3 | 0.806 |
CK1A2 |
0.755 | -0.010 | -3 | 0.415 |
CK2A1 |
0.754 | 0.069 | 1 | 0.762 |
MPSK1 |
0.753 | -0.057 | 1 | 0.659 |
HASPIN |
0.752 | 0.206 | -1 | 0.780 |
BUB1 |
0.752 | 0.081 | -5 | 0.793 |
PINK1 |
0.752 | -0.197 | 1 | 0.742 |
CK1D |
0.752 | -0.034 | -3 | 0.413 |
PDK1 |
0.752 | -0.042 | 1 | 0.715 |
LKB1 |
0.752 | -0.059 | -3 | 0.783 |
ERK7 |
0.751 | -0.006 | 2 | 0.432 |
GCK |
0.751 | -0.008 | 1 | 0.747 |
TAO2 |
0.750 | -0.087 | 2 | 0.710 |
CDK4 |
0.750 | 0.062 | 1 | 0.645 |
CK1G1 |
0.750 | -0.081 | -3 | 0.464 |
PKG1 |
0.749 | 0.040 | -2 | 0.574 |
TTBK1 |
0.749 | -0.165 | 2 | 0.510 |
CAMKK1 |
0.749 | -0.133 | -2 | 0.699 |
MEKK6 |
0.749 | -0.033 | 1 | 0.732 |
HPK1 |
0.748 | 0.002 | 1 | 0.723 |
MAP3K15 |
0.748 | -0.043 | 1 | 0.698 |
CAMKK2 |
0.747 | -0.108 | -2 | 0.692 |
LRRK2 |
0.747 | -0.058 | 2 | 0.719 |
PLK2 |
0.746 | -0.055 | -3 | 0.718 |
CDK6 |
0.745 | 0.041 | 1 | 0.650 |
NEK8 |
0.745 | -0.170 | 2 | 0.686 |
CRIK |
0.744 | 0.065 | -3 | 0.729 |
PBK |
0.744 | -0.005 | 1 | 0.661 |
NEK4 |
0.744 | -0.110 | 1 | 0.694 |
TNIK |
0.744 | -0.040 | 3 | 0.798 |
PDHK3_TYR |
0.743 | 0.191 | 4 | 0.862 |
LOK |
0.743 | -0.042 | -2 | 0.722 |
HGK |
0.743 | -0.088 | 3 | 0.799 |
MST2 |
0.742 | -0.122 | 1 | 0.746 |
MINK |
0.742 | -0.080 | 1 | 0.709 |
EEF2K |
0.742 | -0.099 | 3 | 0.754 |
VRK1 |
0.742 | -0.091 | 2 | 0.747 |
TAK1 |
0.742 | -0.105 | 1 | 0.746 |
NEK1 |
0.742 | -0.092 | 1 | 0.707 |
ROCK1 |
0.741 | 0.072 | -3 | 0.786 |
KHS1 |
0.740 | -0.018 | 1 | 0.694 |
SLK |
0.739 | -0.069 | -2 | 0.651 |
STK33 |
0.739 | -0.101 | 2 | 0.514 |
KHS2 |
0.739 | -0.001 | 1 | 0.717 |
RIPK2 |
0.739 | -0.181 | 1 | 0.664 |
YSK1 |
0.737 | -0.073 | 2 | 0.673 |
MEK2 |
0.735 | -0.194 | 2 | 0.693 |
BMPR2_TYR |
0.734 | 0.134 | -1 | 0.727 |
MST1 |
0.734 | -0.146 | 1 | 0.719 |
TESK1_TYR |
0.733 | 0.004 | 3 | 0.827 |
PDHK4_TYR |
0.732 | 0.049 | 2 | 0.789 |
EPHA6 |
0.732 | 0.143 | -1 | 0.701 |
MAP2K6_TYR |
0.732 | 0.029 | -1 | 0.703 |
PKMYT1_TYR |
0.731 | 0.022 | 3 | 0.814 |
MAP2K4_TYR |
0.731 | -0.050 | -1 | 0.696 |
NEK3 |
0.731 | -0.108 | 1 | 0.675 |
BIKE |
0.730 | -0.019 | 1 | 0.610 |
EPHB4 |
0.729 | 0.092 | -1 | 0.664 |
TTK |
0.729 | -0.018 | -2 | 0.756 |
LIMK2_TYR |
0.729 | 0.043 | -3 | 0.865 |
TNK2 |
0.729 | 0.144 | 3 | 0.816 |
TXK |
0.728 | 0.148 | 1 | 0.871 |
MAP2K7_TYR |
0.726 | -0.161 | 2 | 0.750 |
PDHK1_TYR |
0.724 | -0.041 | -1 | 0.698 |
DDR1 |
0.724 | 0.010 | 4 | 0.778 |
ASK1 |
0.724 | -0.091 | 1 | 0.684 |
PINK1_TYR |
0.724 | -0.100 | 1 | 0.777 |
OSR1 |
0.724 | -0.105 | 2 | 0.686 |
EPHA4 |
0.723 | 0.050 | 2 | 0.708 |
EPHB1 |
0.723 | 0.071 | 1 | 0.832 |
YANK3 |
0.723 | -0.071 | 2 | 0.337 |
SRMS |
0.723 | 0.065 | 1 | 0.842 |
LIMK1_TYR |
0.721 | -0.090 | 2 | 0.722 |
TYRO3 |
0.720 | -0.066 | 3 | 0.789 |
TAO1 |
0.719 | -0.109 | 1 | 0.645 |
EPHB3 |
0.719 | 0.033 | -1 | 0.650 |
AAK1 |
0.719 | 0.012 | 1 | 0.507 |
CK1A |
0.719 | -0.043 | -3 | 0.324 |
EPHB2 |
0.719 | 0.051 | -1 | 0.634 |
MST1R |
0.718 | -0.065 | 3 | 0.825 |
ITK |
0.718 | 0.040 | -1 | 0.630 |
RET |
0.718 | -0.122 | 1 | 0.730 |
BMX |
0.717 | 0.053 | -1 | 0.569 |
MYO3B |
0.717 | -0.114 | 2 | 0.665 |
ALPHAK3 |
0.716 | -0.096 | -1 | 0.616 |
INSRR |
0.716 | 0.005 | 3 | 0.766 |
MERTK |
0.716 | 0.035 | 3 | 0.802 |
AXL |
0.716 | 0.007 | 3 | 0.810 |
EPHA7 |
0.715 | 0.061 | 2 | 0.696 |
CSF1R |
0.715 | -0.050 | 3 | 0.805 |
FER |
0.715 | -0.087 | 1 | 0.844 |
DDR2 |
0.714 | 0.096 | 3 | 0.773 |
ABL2 |
0.714 | -0.030 | -1 | 0.617 |
ROS1 |
0.714 | -0.099 | 3 | 0.778 |
JAK3 |
0.714 | -0.023 | 1 | 0.725 |
TYK2 |
0.713 | -0.187 | 1 | 0.717 |
TNK1 |
0.713 | 0.020 | 3 | 0.773 |
JAK2 |
0.712 | -0.135 | 1 | 0.727 |
PTK2B |
0.712 | 0.053 | -1 | 0.586 |
MYO3A |
0.712 | -0.139 | 1 | 0.693 |
PTK2 |
0.712 | 0.149 | -1 | 0.674 |
EPHA3 |
0.711 | -0.011 | 2 | 0.672 |
FGFR2 |
0.711 | -0.060 | 3 | 0.813 |
YES1 |
0.711 | -0.067 | -1 | 0.629 |
EPHA1 |
0.710 | 0.032 | 3 | 0.813 |
ABL1 |
0.710 | -0.058 | -1 | 0.606 |
BLK |
0.710 | 0.061 | -1 | 0.637 |
LCK |
0.710 | 0.019 | -1 | 0.643 |
HCK |
0.710 | -0.036 | -1 | 0.636 |
MET |
0.710 | -0.002 | 3 | 0.816 |
KDR |
0.709 | -0.006 | 3 | 0.799 |
FGR |
0.709 | -0.118 | 1 | 0.802 |
EPHA5 |
0.709 | 0.036 | 2 | 0.694 |
TEC |
0.709 | -0.028 | -1 | 0.565 |
KIT |
0.709 | -0.064 | 3 | 0.801 |
STLK3 |
0.708 | -0.162 | 1 | 0.687 |
TEK |
0.708 | -0.076 | 3 | 0.747 |
FGFR1 |
0.707 | -0.093 | 3 | 0.792 |
PDGFRB |
0.706 | -0.118 | 3 | 0.814 |
FYN |
0.706 | 0.040 | -1 | 0.629 |
EPHA8 |
0.704 | 0.021 | -1 | 0.650 |
JAK1 |
0.704 | -0.066 | 1 | 0.666 |
NTRK1 |
0.704 | -0.098 | -1 | 0.637 |
BTK |
0.703 | -0.146 | -1 | 0.603 |
TNNI3K_TYR |
0.702 | -0.097 | 1 | 0.751 |
LTK |
0.702 | -0.096 | 3 | 0.762 |
FLT3 |
0.702 | -0.156 | 3 | 0.793 |
EPHA2 |
0.702 | 0.049 | -1 | 0.626 |
NEK10_TYR |
0.701 | -0.138 | 1 | 0.590 |
FGFR3 |
0.701 | -0.063 | 3 | 0.795 |
ALK |
0.700 | -0.109 | 3 | 0.745 |
WEE1_TYR |
0.700 | -0.112 | -1 | 0.634 |
FLT1 |
0.699 | -0.060 | -1 | 0.665 |
NTRK2 |
0.699 | -0.108 | 3 | 0.782 |
NTRK3 |
0.699 | -0.073 | -1 | 0.598 |
FRK |
0.699 | -0.060 | -1 | 0.639 |
INSR |
0.698 | -0.095 | 3 | 0.740 |
SYK |
0.697 | 0.060 | -1 | 0.631 |
FLT4 |
0.696 | -0.114 | 3 | 0.765 |
PDGFRA |
0.696 | -0.207 | 3 | 0.809 |
ERBB2 |
0.696 | -0.126 | 1 | 0.722 |
LYN |
0.695 | -0.076 | 3 | 0.721 |
EGFR |
0.692 | -0.068 | 1 | 0.654 |
SRC |
0.692 | -0.058 | -1 | 0.603 |
PTK6 |
0.692 | -0.246 | -1 | 0.574 |
CSK |
0.692 | -0.120 | 2 | 0.696 |
ERBB4 |
0.690 | 0.011 | 1 | 0.696 |
MATK |
0.690 | -0.113 | -1 | 0.563 |
YANK2 |
0.689 | -0.095 | 2 | 0.347 |
FGFR4 |
0.688 | -0.088 | -1 | 0.580 |
CK1G3 |
0.686 | -0.099 | -3 | 0.281 |
IGF1R |
0.684 | -0.092 | 3 | 0.679 |
FES |
0.684 | -0.041 | -1 | 0.544 |
MUSK |
0.681 | -0.120 | 1 | 0.617 |
CK1G2 |
0.674 | -0.070 | -3 | 0.380 |
ZAP70 |
0.670 | -0.028 | -1 | 0.583 |