Motif 417 (n=80)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A0MRY4 | None | S270 | ochoa | Spermatogenesis-associated protein 13 | None |
| A0AVT1 | UBA6 | S36 | ochoa | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| E9PCH4 | None | S1144 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O00167 | EYA2 | S257 | ochoa | Protein phosphatase EYA2 (EC 3.1.3.48) (Eyes absent homolog 2) | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047, ECO:0000269|PubMed:23435380}. |
| O43491 | EPB41L2 | S518 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60237 | PPP1R12B | S855 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| P08670 | VIM | S73 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P09086 | POU2F2 | S250 | ochoa | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250|UniProtKB:Q00196, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980}. |
| P11171 | EPB41 | S510 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P13569 | CFTR | S790 | psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| P14859 | POU2F1 | S335 | ochoa|psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P22314 | UBA1 | S877 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P25686 | DNAJB2 | S242 | ochoa | DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}. |
| P27635 | RPL10 | S137 | ochoa | Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) | Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}. |
| P30566 | ADSL | S334 | ochoa | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| P49005 | POLD2 | S257 | ochoa | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}. |
| P62995 | TRA2B | S215 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| Q00613 | HSF1 | S333 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q01484 | ANK2 | S890 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02241 | KIF23 | S298 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q06787 | FMR1 | S500 | ochoa|psp | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) | Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:12417522, PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522, PubMed:30765518, PubMed:31439799). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (PubMed:30765518). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11157796, PubMed:11532944, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:11157796, PubMed:11719189, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548, PubMed:7692601). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529, PubMed:7692601). Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export (PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:12950170, PubMed:15381419, PubMed:7688265, PubMed:7781595, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (PubMed:39106863). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:11157796, ECO:0000269|PubMed:11532944, ECO:0000269|PubMed:11719189, ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:12594214, ECO:0000269|PubMed:12927206, ECO:0000269|PubMed:12950170, ECO:0000269|PubMed:14703574, ECO:0000269|PubMed:15282548, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15805463, ECO:0000269|PubMed:16631377, ECO:0000269|PubMed:17057366, ECO:0000269|PubMed:17417632, ECO:0000269|PubMed:18579868, ECO:0000269|PubMed:18653529, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:19097999, ECO:0000269|PubMed:19166269, ECO:0000269|PubMed:20512134, ECO:0000269|PubMed:23235829, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:24448548, ECO:0000269|PubMed:24813610, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:25561520, ECO:0000269|PubMed:25692235, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:31753916, ECO:0000269|PubMed:39106863, ECO:0000269|PubMed:7688265, ECO:0000269|PubMed:7692601, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8156595}.; FUNCTION: [Isoform 10]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: [Isoform 6]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components. {ECO:0000269|PubMed:24514761}. |
| Q08378 | GOLGA3 | S282 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12955 | ANK3 | S934 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q14149 | MORC3 | S550 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14451 | GRB7 | S357 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14524 | SCN5A | S528 | psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q15334 | LLGL1 | S663 | ochoa|psp | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15811 | ITSN1 | S976 | ochoa | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
| Q53EL6 | PDCD4 | S71 | ochoa|psp | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5JSZ5 | PRRC2B | S248 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SW79 | CEP170 | S1101 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T5Y3 | CAMSAP1 | S1139 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q69YH5 | CDCA2 | S199 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6PIW4 | FIGNL1 | S259 | ochoa | Fidgetin-like protein 1 (EC 3.6.4.-) | Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376}. |
| Q70CQ2 | USP34 | S1458 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q7Z3K3 | POGZ | S1327 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z460 | CLASP1 | S636 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z460 | CLASP1 | S787 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q86YN6 | PPARGC1B | S763 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q8IVL1 | NAV2 | S1190 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8N137 | CNTROB | S36 | psp | Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}. |
| Q8N573 | OXR1 | S301 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8TEQ6 | GEMIN5 | S1311 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8TEU7 | RAPGEF6 | S1094 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q96CC6 | RHBDF1 | S240 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96HH9 | GRAMD2B | S241 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96QT4 | TRPM7 | S1287 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q99569 | PKP4 | S461 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q9BQ70 | TCF25 | S172 | ochoa | Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}. |
| Q9BRI3 | SLC30A2 | S296 | psp | Proton-coupled zinc antiporter SLC30A2 (Solute carrier family 30 member 2) (Zinc transporter 2) (ZnT-2) | [Isoform 1]: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:17065149, PubMed:21289295, PubMed:22733820, PubMed:25657003, PubMed:25808614, PubMed:30893306). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614). {ECO:0000269|PubMed:17065149, ECO:0000269|PubMed:19496757, ECO:0000269|PubMed:21289295, ECO:0000269|PubMed:22733820, ECO:0000269|PubMed:25657003, ECO:0000269|PubMed:25808614, ECO:0000269|PubMed:30893306}.; FUNCTION: [Isoform 2]: Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane. {ECO:0000269|PubMed:19496757}. |
| Q9BV36 | MLPH | S569 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BXF6 | RAB11FIP5 | S243 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BYI3 | HYCC1 | S451 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9H299 | SH3BGRL3 | S22 | ochoa | SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1) | Could act as a modulator of glutaredoxin biological activity (Probable). May play a role in cytoskeleton organization (PubMed:34380438). {ECO:0000269|PubMed:34380438, ECO:0000305|PubMed:15907482}. |
| Q9H4G0 | EPB41L1 | S396 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4G0 | EPB41L1 | S430 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H6W3 | RIOX1 | S60 | ochoa | Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}. |
| Q9H9A7 | RMI1 | S400 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HCD5 | NCOA5 | S96 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9NQT8 | KIF13B | S1294 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9P0J7 | KCMF1 | S212 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P2J5 | LARS1 | S720 | ochoa | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q9UKI9 | POU2F3 | S238 | ochoa | POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). {ECO:0000269|PubMed:11329378, ECO:0000269|PubMed:35576971}. |
| Q9ULW0 | TPX2 | S310 | ochoa|psp | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9ULX3 | NOB1 | S325 | ochoa | RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4) | May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). {ECO:0000250|UniProtKB:Q9FLL1, ECO:0000305}. |
| Q9UPP1 | PHF8 | S1024 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9Y2I1 | NISCH | S1038 | ochoa | Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) | Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Also inhibits LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. {ECO:0000250, ECO:0000269|PubMed:10882231, ECO:0000269|PubMed:12868002, ECO:0000269|PubMed:15028619, ECO:0000269|PubMed:15028621, ECO:0000269|PubMed:15475348}. |
| Q9Y2J2 | EPB41L3 | S409 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y426 | C2CD2 | S511 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y485 | DMXL1 | S1896 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4G8 | RAPGEF2 | S960 | ochoa|psp | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y6R0 | NUMBL | S228 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| P32929 | CTH | S56 | Sugiyama | Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) | Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19019829, PubMed:19261609, PubMed:19961860). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}. |
| Q9Y6A5 | TACC3 | S34 | SIGNOR | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| O60566 | BUB1B | S694 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| P08253 | MMP2 | S365 | EPSD|PSP | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. |
| P43686 | PSMC4 | S117 | Sugiyama | 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}. |
| Q5VUE5 | C1orf53 | S67 | Sugiyama | Uncharacterized protein C1orf53 | None |
| Q5S007 | LRRK2 | S2257 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q00403 | GTF2B | S99 | Sugiyama | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.000829 | 3.081 |
| R-HSA-1640170 | Cell Cycle | 0.000616 | 3.210 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001395 | 2.855 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.000350 | 3.456 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.001097 | 2.960 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.001764 | 2.754 |
| R-HSA-422475 | Axon guidance | 0.001064 | 2.973 |
| R-HSA-9675108 | Nervous system development | 0.001701 | 2.769 |
| R-HSA-9646399 | Aggrephagy | 0.002267 | 2.644 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.002822 | 2.549 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.003346 | 2.475 |
| R-HSA-68886 | M Phase | 0.006683 | 2.175 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.007198 | 2.143 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.008259 | 2.083 |
| R-HSA-449147 | Signaling by Interleukins | 0.008855 | 2.053 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.010553 | 1.977 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.032263 | 1.491 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.015979 | 1.796 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.015979 | 1.796 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.093733 | 1.028 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.108488 | 0.965 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.113353 | 0.946 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.118192 | 0.927 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.123005 | 0.910 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.127791 | 0.893 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.127791 | 0.893 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.127791 | 0.893 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.127791 | 0.893 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.132552 | 0.878 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.034406 | 1.463 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.137288 | 0.862 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.141997 | 0.848 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.043034 | 1.366 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.044327 | 1.353 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.155975 | 0.807 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.015531 | 1.809 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.165167 | 0.782 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.174261 | 0.759 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.062363 | 1.205 |
| R-HSA-390522 | Striated Muscle Contraction | 0.196570 | 0.706 |
| R-HSA-3371511 | HSF1 activation | 0.209668 | 0.678 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.093945 | 1.027 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.093945 | 1.027 |
| R-HSA-3371568 | Attenuation phase | 0.226804 | 0.644 |
| R-HSA-167161 | HIV Transcription Initiation | 0.235233 | 0.629 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.235233 | 0.629 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.104164 | 0.982 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.105896 | 0.975 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.112900 | 0.947 |
| R-HSA-192823 | Viral mRNA Translation | 0.129077 | 0.889 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.138288 | 0.859 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.098678 | 1.006 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.123625 | 0.908 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.020508 | 1.688 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.019564 | 1.709 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.147638 | 0.831 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.226804 | 0.644 |
| R-HSA-156902 | Peptide chain elongation | 0.099016 | 1.004 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.147638 | 0.831 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.084062 | 1.075 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.014305 | 1.845 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.048007 | 1.319 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.108488 | 0.965 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.192156 | 0.716 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.200959 | 0.697 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.140147 | 0.853 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.132552 | 0.878 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.046954 | 1.328 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.114670 | 0.941 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.032151 | 1.493 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.219924 | 0.658 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.200959 | 0.697 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.235233 | 0.629 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.048289 | 1.316 |
| R-HSA-5693538 | Homology Directed Repair | 0.036125 | 1.442 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.053198 | 1.274 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.151341 | 0.820 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.169727 | 0.770 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.183257 | 0.737 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.066827 | 1.175 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.200959 | 0.697 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.235233 | 0.629 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.114670 | 0.941 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.116447 | 0.934 |
| R-HSA-69190 | DNA strand elongation | 0.187719 | 0.726 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.107635 | 0.968 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.226804 | 0.644 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.226804 | 0.644 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.239414 | 0.621 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.090608 | 1.043 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.218282 | 0.661 |
| R-HSA-8852135 | Protein ubiquitination | 0.076060 | 1.119 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.078260 | 1.106 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.069860 | 1.156 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.069860 | 1.156 |
| R-HSA-5619084 | ABC transporter disorders | 0.080820 | 1.092 |
| R-HSA-72766 | Translation | 0.100570 | 0.998 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.027629 | 1.559 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.165167 | 0.782 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.187719 | 0.726 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.205325 | 0.688 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.205325 | 0.688 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.235233 | 0.629 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.235233 | 0.629 |
| R-HSA-69239 | Synthesis of DNA | 0.138288 | 0.859 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.140147 | 0.853 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.160583 | 0.794 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.178771 | 0.748 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.168635 | 0.773 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.063497 | 1.197 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.205325 | 0.688 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 0.174261 | 0.759 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.123625 | 0.908 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.037539 | 1.426 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.205325 | 0.688 |
| R-HSA-4641258 | Degradation of DVL | 0.213986 | 0.670 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.125436 | 0.902 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.085353 | 1.069 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.014645 | 1.834 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.053198 | 1.274 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.078738 | 1.104 |
| R-HSA-69109 | Leading Strand Synthesis | 0.083763 | 1.077 |
| R-HSA-69091 | Polymerase switching | 0.083763 | 1.077 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.183257 | 0.737 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.071394 | 1.146 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.209668 | 0.678 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.209668 | 0.678 |
| R-HSA-4641257 | Degradation of AXIN | 0.213986 | 0.670 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.213986 | 0.670 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.130908 | 0.883 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.209668 | 0.678 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.209668 | 0.678 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.174261 | 0.759 |
| R-HSA-983189 | Kinesins | 0.053763 | 1.270 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.056580 | 1.247 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.196570 | 0.706 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.200959 | 0.697 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.200959 | 0.697 |
| R-HSA-169911 | Regulation of Apoptosis | 0.205325 | 0.688 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.235233 | 0.629 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.235233 | 0.629 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.142012 | 0.848 |
| R-HSA-69242 | S Phase | 0.229958 | 0.638 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.159024 | 0.799 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.017970 | 1.745 |
| R-HSA-69275 | G2/M Transition | 0.026348 | 1.579 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.116447 | 0.934 |
| R-HSA-9612973 | Autophagy | 0.070492 | 1.152 |
| R-HSA-9663891 | Selective autophagy | 0.016405 | 1.785 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.027170 | 1.566 |
| R-HSA-3214842 | HDMs demethylate histones | 0.155975 | 0.807 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.180171 | 0.744 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.055165 | 1.258 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.155975 | 0.807 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.231030 | 0.636 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.231030 | 0.636 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.140147 | 0.853 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.159024 | 0.799 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.066423 | 1.178 |
| R-HSA-435354 | Zinc transporters | 0.093733 | 1.028 |
| R-HSA-9659379 | Sensory processing of sound | 0.082427 | 1.084 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.227949 | 0.642 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.066747 | 1.176 |
| R-HSA-73894 | DNA Repair | 0.154878 | 0.810 |
| R-HSA-3295583 | TRP channels | 0.160583 | 0.794 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.065327 | 1.185 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.196570 | 0.706 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.222554 | 0.653 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.222554 | 0.653 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.231030 | 0.636 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.069921 | 1.155 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.130908 | 0.883 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.104782 | 0.980 |
| R-HSA-199991 | Membrane Trafficking | 0.159604 | 0.797 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.048289 | 1.316 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.231030 | 0.636 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.113353 | 0.946 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.192156 | 0.716 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.226804 | 0.644 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.231030 | 0.636 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.194050 | 0.712 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.107635 | 0.968 |
| R-HSA-1632852 | Macroautophagy | 0.056089 | 1.251 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.113353 | 0.946 |
| R-HSA-9629569 | Protein hydroxylation | 0.127791 | 0.893 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.074494 | 1.128 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.238009 | 0.623 |
| R-HSA-68882 | Mitotic Anaphase | 0.139311 | 0.856 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.140565 | 0.852 |
| R-HSA-72312 | rRNA processing | 0.159818 | 0.796 |
| R-HSA-68875 | Mitotic Prophase | 0.037503 | 1.426 |
| R-HSA-69481 | G2/M Checkpoints | 0.182251 | 0.739 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.187719 | 0.726 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.095627 | 1.019 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.088474 | 1.053 |
| R-HSA-373760 | L1CAM interactions | 0.034773 | 1.459 |
| R-HSA-210993 | Tie2 Signaling | 0.118192 | 0.927 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.231030 | 0.636 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.141997 | 0.848 |
| R-HSA-69541 | Stabilization of p53 | 0.222554 | 0.653 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.033828 | 1.471 |
| R-HSA-5688426 | Deubiquitination | 0.190774 | 0.719 |
| R-HSA-186763 | Downstream signal transduction | 0.183257 | 0.737 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.164778 | 0.783 |
| R-HSA-5358508 | Mismatch Repair | 0.118192 | 0.927 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.092272 | 1.035 |
| R-HSA-8853659 | RET signaling | 0.209668 | 0.678 |
| R-HSA-1266738 | Developmental Biology | 0.018981 | 1.722 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.060899 | 1.215 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.077637 | 1.110 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.143712 | 0.843 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.097317 | 1.012 |
| R-HSA-69306 | DNA Replication | 0.240025 | 0.620 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.243572 | 0.613 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.243572 | 0.613 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.243572 | 0.613 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.244058 | 0.613 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.247708 | 0.606 |
| R-HSA-9907900 | Proteasome assembly | 0.247708 | 0.606 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.247708 | 0.606 |
| R-HSA-9711097 | Cellular response to starvation | 0.250113 | 0.602 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.251821 | 0.599 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.251821 | 0.599 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.251821 | 0.599 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.251821 | 0.599 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.251821 | 0.599 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.251821 | 0.599 |
| R-HSA-9824272 | Somitogenesis | 0.251821 | 0.599 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.251821 | 0.599 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.254153 | 0.595 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.255912 | 0.592 |
| R-HSA-9675135 | Diseases of DNA repair | 0.255912 | 0.592 |
| R-HSA-75153 | Apoptotic execution phase | 0.255912 | 0.592 |
| R-HSA-109581 | Apoptosis | 0.258195 | 0.588 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.259981 | 0.585 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.259981 | 0.585 |
| R-HSA-425410 | Metal ion SLC transporters | 0.264028 | 0.578 |
| R-HSA-73893 | DNA Damage Bypass | 0.268053 | 0.572 |
| R-HSA-9766229 | Degradation of CDH1 | 0.268053 | 0.572 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.268053 | 0.572 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.268053 | 0.572 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.271061 | 0.567 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.272056 | 0.565 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.276038 | 0.559 |
| R-HSA-912446 | Meiotic recombination | 0.276038 | 0.559 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.276038 | 0.559 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.276038 | 0.559 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.276038 | 0.559 |
| R-HSA-112316 | Neuronal System | 0.278671 | 0.555 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.279998 | 0.553 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.279998 | 0.553 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.282455 | 0.549 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.282455 | 0.549 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.283937 | 0.547 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.283937 | 0.547 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.283937 | 0.547 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.286495 | 0.543 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.287854 | 0.541 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.287854 | 0.541 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.291751 | 0.535 |
| R-HSA-168255 | Influenza Infection | 0.294570 | 0.531 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.295626 | 0.529 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.295626 | 0.529 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.299480 | 0.524 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.300061 | 0.523 |
| R-HSA-162582 | Signal Transduction | 0.301224 | 0.521 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.302633 | 0.519 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.303313 | 0.518 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.307126 | 0.513 |
| R-HSA-191859 | snRNP Assembly | 0.307126 | 0.513 |
| R-HSA-180786 | Extension of Telomeres | 0.307126 | 0.513 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.307126 | 0.513 |
| R-HSA-379724 | tRNA Aminoacylation | 0.310918 | 0.507 |
| R-HSA-351202 | Metabolism of polyamines | 0.310918 | 0.507 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.310918 | 0.507 |
| R-HSA-1442490 | Collagen degradation | 0.314689 | 0.502 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.314689 | 0.502 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.318440 | 0.497 |
| R-HSA-186797 | Signaling by PDGF | 0.318440 | 0.497 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.322171 | 0.492 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.322171 | 0.492 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.322171 | 0.492 |
| R-HSA-8848021 | Signaling by PTK6 | 0.322171 | 0.492 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.322171 | 0.492 |
| R-HSA-68877 | Mitotic Prometaphase | 0.322718 | 0.491 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.324842 | 0.488 |
| R-HSA-8953854 | Metabolism of RNA | 0.326126 | 0.487 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.328719 | 0.483 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.329572 | 0.482 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.336698 | 0.473 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.336893 | 0.473 |
| R-HSA-167172 | Transcription of the HIV genome | 0.340524 | 0.468 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.340678 | 0.468 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.347727 | 0.459 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.347727 | 0.459 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.347727 | 0.459 |
| R-HSA-5357801 | Programmed Cell Death | 0.348616 | 0.458 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.351299 | 0.454 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.351299 | 0.454 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.354852 | 0.450 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.354852 | 0.450 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.358385 | 0.446 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.358385 | 0.446 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.358385 | 0.446 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.361900 | 0.441 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.361900 | 0.441 |
| R-HSA-397014 | Muscle contraction | 0.362432 | 0.441 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.364397 | 0.438 |
| R-HSA-380287 | Centrosome maturation | 0.365395 | 0.437 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.365395 | 0.437 |
| R-HSA-5689603 | UCH proteinases | 0.368872 | 0.433 |
| R-HSA-418990 | Adherens junctions interactions | 0.374189 | 0.427 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.375769 | 0.425 |
| R-HSA-4086400 | PCP/CE pathway | 0.375769 | 0.425 |
| R-HSA-8951664 | Neddylation | 0.380037 | 0.420 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.385974 | 0.413 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.385974 | 0.413 |
| R-HSA-162906 | HIV Infection | 0.391663 | 0.407 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.392686 | 0.406 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.396015 | 0.402 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.396015 | 0.402 |
| R-HSA-1500620 | Meiosis | 0.399325 | 0.399 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.402618 | 0.395 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.405893 | 0.392 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.405893 | 0.392 |
| R-HSA-8939211 | ESR-mediated signaling | 0.410826 | 0.386 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.412389 | 0.385 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.415611 | 0.381 |
| R-HSA-157118 | Signaling by NOTCH | 0.416519 | 0.380 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.418816 | 0.378 |
| R-HSA-73884 | Base Excision Repair | 0.418816 | 0.378 |
| R-HSA-202424 | Downstream TCR signaling | 0.418816 | 0.378 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.429696 | 0.367 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.431460 | 0.365 |
| R-HSA-421270 | Cell-cell junction organization | 0.437158 | 0.359 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.443833 | 0.353 |
| R-HSA-157579 | Telomere Maintenance | 0.446885 | 0.350 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.446885 | 0.350 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.452938 | 0.344 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.455940 | 0.341 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.458925 | 0.338 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.458925 | 0.338 |
| R-HSA-392499 | Metabolism of proteins | 0.460026 | 0.337 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.461895 | 0.335 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.473613 | 0.325 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.482235 | 0.317 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.482235 | 0.317 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.485078 | 0.314 |
| R-HSA-446728 | Cell junction organization | 0.486107 | 0.313 |
| R-HSA-202403 | TCR signaling | 0.487906 | 0.312 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.501815 | 0.299 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.505297 | 0.296 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.512673 | 0.290 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.517269 | 0.286 |
| R-HSA-195721 | Signaling by WNT | 0.520655 | 0.283 |
| R-HSA-3371556 | Cellular response to heat stress | 0.523297 | 0.281 |
| R-HSA-73886 | Chromosome Maintenance | 0.523297 | 0.281 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.523297 | 0.281 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.528522 | 0.277 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.531114 | 0.275 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.531114 | 0.275 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.536255 | 0.271 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.536255 | 0.271 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.536255 | 0.271 |
| R-HSA-69206 | G1/S Transition | 0.536255 | 0.271 |
| R-HSA-1500931 | Cell-Cell communication | 0.550422 | 0.259 |
| R-HSA-1474165 | Reproduction | 0.551346 | 0.259 |
| R-HSA-9843745 | Adipogenesis | 0.553813 | 0.257 |
| R-HSA-5576891 | Cardiac conduction | 0.553813 | 0.257 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.556267 | 0.255 |
| R-HSA-9909396 | Circadian clock | 0.556267 | 0.255 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.556862 | 0.254 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.568339 | 0.245 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.568339 | 0.245 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.573076 | 0.242 |
| R-HSA-6807070 | PTEN Regulation | 0.575426 | 0.240 |
| R-HSA-597592 | Post-translational protein modification | 0.576394 | 0.239 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.584696 | 0.233 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.589256 | 0.230 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.593766 | 0.226 |
| R-HSA-9758941 | Gastrulation | 0.600440 | 0.222 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.602640 | 0.220 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.604828 | 0.218 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.607005 | 0.217 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.611322 | 0.214 |
| R-HSA-73887 | Death Receptor Signaling | 0.611322 | 0.214 |
| R-HSA-1989781 | PPARA activates gene expression | 0.613464 | 0.212 |
| R-HSA-162587 | HIV Life Cycle | 0.617711 | 0.209 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.617711 | 0.209 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.619817 | 0.208 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.621983 | 0.206 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.648129 | 0.188 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.650069 | 0.187 |
| R-HSA-983712 | Ion channel transport | 0.681486 | 0.167 |
| R-HSA-168256 | Immune System | 0.681698 | 0.166 |
| R-HSA-5617833 | Cilium Assembly | 0.683244 | 0.165 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.690183 | 0.161 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.700311 | 0.155 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.700341 | 0.155 |
| R-HSA-1280218 | Adaptive Immune System | 0.700564 | 0.155 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.705251 | 0.152 |
| R-HSA-72172 | mRNA Splicing | 0.708499 | 0.150 |
| R-HSA-6805567 | Keratinization | 0.711713 | 0.148 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.721144 | 0.142 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.741981 | 0.130 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.744829 | 0.128 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.747945 | 0.126 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.753188 | 0.123 |
| R-HSA-15869 | Metabolism of nucleotides | 0.755914 | 0.122 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.757265 | 0.121 |
| R-HSA-9824446 | Viral Infection Pathways | 0.760105 | 0.119 |
| R-HSA-4839726 | Chromatin organization | 0.772920 | 0.112 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.781587 | 0.107 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.795689 | 0.099 |
| R-HSA-382551 | Transport of small molecules | 0.804586 | 0.094 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.807824 | 0.093 |
| R-HSA-109582 | Hemostasis | 0.822016 | 0.085 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.824212 | 0.084 |
| R-HSA-2262752 | Cellular responses to stress | 0.826894 | 0.083 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.840042 | 0.076 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.849634 | 0.071 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.849634 | 0.071 |
| R-HSA-1474244 | Extracellular matrix organization | 0.856205 | 0.067 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.864778 | 0.063 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.869969 | 0.060 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.888182 | 0.051 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.901181 | 0.045 |
| R-HSA-74160 | Gene expression (Transcription) | 0.929420 | 0.032 |
| R-HSA-6798695 | Neutrophil degranulation | 0.929472 | 0.032 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.949156 | 0.023 |
| R-HSA-9679506 | SARS-CoV Infections | 0.959458 | 0.018 |
| R-HSA-5663205 | Infectious disease | 0.963693 | 0.016 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.970834 | 0.013 |
| R-HSA-212436 | Generic Transcription Pathway | 0.977051 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 0.988385 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 0.992801 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 0.993416 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.995922 | 0.002 |
| R-HSA-1643685 | Disease | 0.997246 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999826 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999962 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.833 | 0.575 | -2 | 0.882 |
AURB |
0.824 | 0.580 | -2 | 0.885 |
RSK3 |
0.820 | 0.390 | -3 | 0.709 |
PKACG |
0.820 | 0.457 | -2 | 0.818 |
PKCD |
0.818 | 0.404 | 2 | 0.823 |
RSK2 |
0.817 | 0.365 | -3 | 0.716 |
PKG2 |
0.817 | 0.502 | -2 | 0.839 |
AKT1 |
0.816 | 0.484 | -3 | 0.668 |
PKCA |
0.816 | 0.398 | 2 | 0.802 |
PKACB |
0.815 | 0.491 | -2 | 0.868 |
MNK2 |
0.815 | 0.463 | -2 | 0.880 |
AURA |
0.814 | 0.563 | -2 | 0.887 |
PKN2 |
0.814 | 0.369 | -3 | 0.761 |
RSK4 |
0.814 | 0.400 | -3 | 0.675 |
PIM3 |
0.814 | 0.266 | -3 | 0.745 |
PAK3 |
0.813 | 0.496 | -2 | 0.889 |
PAK1 |
0.813 | 0.480 | -2 | 0.902 |
SGK3 |
0.812 | 0.440 | -3 | 0.697 |
MST4 |
0.812 | 0.284 | 2 | 0.843 |
PAK6 |
0.812 | 0.467 | -2 | 0.902 |
MNK1 |
0.811 | 0.435 | -2 | 0.867 |
AKT2 |
0.811 | 0.398 | -3 | 0.671 |
PKN3 |
0.811 | 0.290 | -3 | 0.757 |
PKCG |
0.810 | 0.341 | 2 | 0.785 |
WNK1 |
0.810 | 0.308 | -2 | 0.764 |
PKCH |
0.810 | 0.383 | 2 | 0.796 |
P90RSK |
0.810 | 0.300 | -3 | 0.725 |
P70S6KB |
0.809 | 0.372 | -3 | 0.744 |
NDR1 |
0.808 | 0.277 | -3 | 0.733 |
PKACA |
0.808 | 0.479 | -2 | 0.845 |
PRKX |
0.808 | 0.424 | -3 | 0.607 |
PRKD2 |
0.808 | 0.227 | -3 | 0.686 |
PIM1 |
0.808 | 0.288 | -3 | 0.721 |
PKCB |
0.807 | 0.297 | 2 | 0.793 |
MSK1 |
0.807 | 0.436 | -3 | 0.703 |
MYLK4 |
0.806 | 0.465 | -2 | 0.882 |
PAK2 |
0.806 | 0.503 | -2 | 0.894 |
PKCT |
0.806 | 0.408 | 2 | 0.798 |
PKCI |
0.806 | 0.435 | 2 | 0.814 |
MSK2 |
0.806 | 0.370 | -3 | 0.709 |
PKCZ |
0.806 | 0.349 | 2 | 0.820 |
CLK3 |
0.805 | 0.250 | 1 | 0.705 |
PIM2 |
0.805 | 0.357 | -3 | 0.711 |
AKT3 |
0.805 | 0.424 | -3 | 0.607 |
CAMLCK |
0.804 | 0.492 | -2 | 0.844 |
NUAK2 |
0.804 | 0.186 | -3 | 0.767 |
COT |
0.804 | 0.052 | 2 | 0.786 |
CDKL5 |
0.803 | 0.178 | -3 | 0.758 |
CDKL1 |
0.803 | 0.187 | -3 | 0.766 |
PKCE |
0.803 | 0.420 | 2 | 0.788 |
ULK2 |
0.803 | 0.082 | 2 | 0.798 |
CLK4 |
0.803 | 0.383 | -3 | 0.729 |
NDR2 |
0.803 | 0.147 | -3 | 0.717 |
CLK1 |
0.802 | 0.333 | -3 | 0.704 |
SKMLCK |
0.802 | 0.359 | -2 | 0.832 |
RAF1 |
0.801 | 0.121 | 1 | 0.830 |
CAMK1B |
0.800 | 0.264 | -3 | 0.800 |
SRPK1 |
0.800 | 0.185 | -3 | 0.718 |
SRPK2 |
0.800 | 0.202 | -3 | 0.665 |
NLK |
0.799 | 0.141 | 1 | 0.723 |
DAPK2 |
0.799 | 0.430 | -3 | 0.801 |
CAMK4 |
0.799 | 0.306 | -3 | 0.745 |
AMPKA1 |
0.799 | 0.196 | -3 | 0.756 |
PRKD3 |
0.799 | 0.223 | -3 | 0.700 |
PRKD1 |
0.799 | 0.130 | -3 | 0.725 |
RIPK3 |
0.799 | 0.172 | 3 | 0.650 |
NIK |
0.799 | 0.339 | -3 | 0.793 |
PHKG1 |
0.799 | 0.221 | -3 | 0.739 |
GCN2 |
0.798 | -0.008 | 2 | 0.806 |
AMPKA2 |
0.798 | 0.197 | -3 | 0.728 |
WNK3 |
0.798 | 0.180 | 1 | 0.796 |
CDC7 |
0.798 | 0.017 | 1 | 0.756 |
P70S6K |
0.798 | 0.336 | -3 | 0.691 |
PHKG2 |
0.798 | 0.279 | -3 | 0.728 |
PAK5 |
0.797 | 0.474 | -2 | 0.874 |
ICK |
0.797 | 0.206 | -3 | 0.779 |
IRE1 |
0.797 | 0.184 | 1 | 0.750 |
NEK2 |
0.796 | 0.283 | 2 | 0.843 |
MELK |
0.795 | 0.201 | -3 | 0.728 |
IKKB |
0.794 | -0.044 | -2 | 0.589 |
MLK1 |
0.794 | 0.110 | 2 | 0.834 |
MTOR |
0.794 | -0.002 | 1 | 0.720 |
PKN1 |
0.794 | 0.314 | -3 | 0.705 |
MAPKAPK3 |
0.794 | 0.143 | -3 | 0.701 |
HIPK4 |
0.794 | 0.104 | 1 | 0.646 |
IRE2 |
0.793 | 0.201 | 2 | 0.828 |
TSSK1 |
0.793 | 0.158 | -3 | 0.761 |
MRCKB |
0.793 | 0.460 | -3 | 0.694 |
TBK1 |
0.793 | -0.007 | 1 | 0.773 |
SGK1 |
0.793 | 0.373 | -3 | 0.598 |
NUAK1 |
0.792 | 0.115 | -3 | 0.722 |
NEK9 |
0.792 | 0.114 | 2 | 0.839 |
CHAK2 |
0.792 | 0.068 | -1 | 0.826 |
LATS2 |
0.792 | 0.088 | -5 | 0.703 |
PDHK1 |
0.792 | -0.001 | 1 | 0.820 |
DSTYK |
0.791 | 0.006 | 2 | 0.823 |
SMMLCK |
0.791 | 0.439 | -3 | 0.775 |
PRPK |
0.791 | -0.074 | -1 | 0.768 |
CLK2 |
0.791 | 0.318 | -3 | 0.700 |
NEK6 |
0.791 | 0.042 | -2 | 0.615 |
ATR |
0.791 | 0.063 | 1 | 0.745 |
ULK1 |
0.791 | -0.004 | -3 | 0.766 |
SRPK3 |
0.790 | 0.175 | -3 | 0.713 |
PAK4 |
0.790 | 0.459 | -2 | 0.894 |
SNRK |
0.790 | 0.162 | 2 | 0.737 |
NIM1 |
0.790 | 0.085 | 3 | 0.686 |
RIPK1 |
0.790 | 0.132 | 1 | 0.805 |
TGFBR2 |
0.790 | 0.009 | -2 | 0.554 |
DYRK3 |
0.789 | 0.311 | 1 | 0.585 |
MARK4 |
0.789 | 0.052 | 4 | 0.821 |
PDHK4 |
0.789 | -0.102 | 1 | 0.801 |
QIK |
0.789 | 0.110 | -3 | 0.779 |
ERK5 |
0.789 | 0.026 | 1 | 0.697 |
QSK |
0.788 | 0.120 | 4 | 0.799 |
NEK7 |
0.787 | 0.010 | -3 | 0.802 |
CHAK1 |
0.787 | 0.134 | 2 | 0.777 |
PKG1 |
0.787 | 0.429 | -2 | 0.818 |
SIK |
0.787 | 0.115 | -3 | 0.706 |
BRSK2 |
0.787 | 0.106 | -3 | 0.745 |
BRSK1 |
0.787 | 0.128 | -3 | 0.721 |
IKKE |
0.787 | -0.043 | 1 | 0.769 |
MOS |
0.787 | -0.038 | 1 | 0.766 |
TSSK2 |
0.786 | 0.110 | -5 | 0.685 |
CAMK2D |
0.786 | 0.053 | -3 | 0.776 |
MLK3 |
0.786 | 0.103 | 2 | 0.793 |
HIPK1 |
0.786 | 0.181 | 1 | 0.575 |
CAMK1G |
0.786 | 0.217 | -3 | 0.741 |
HUNK |
0.786 | 0.026 | 2 | 0.727 |
PKR |
0.785 | 0.228 | 1 | 0.801 |
MRCKA |
0.785 | 0.430 | -3 | 0.700 |
BCKDK |
0.785 | -0.045 | -1 | 0.713 |
HIPK3 |
0.784 | 0.180 | 1 | 0.591 |
CDK10 |
0.784 | 0.172 | 1 | 0.492 |
ROCK2 |
0.784 | 0.448 | -3 | 0.708 |
BMPR2 |
0.784 | -0.102 | -2 | 0.656 |
IRAK4 |
0.783 | 0.192 | 1 | 0.790 |
CAMK2G |
0.781 | -0.062 | 2 | 0.730 |
WNK4 |
0.781 | 0.192 | -2 | 0.725 |
ROCK1 |
0.781 | 0.474 | -3 | 0.696 |
MLK2 |
0.781 | 0.021 | 2 | 0.816 |
MST3 |
0.781 | 0.252 | 2 | 0.834 |
DYRK2 |
0.780 | 0.091 | 1 | 0.553 |
DAPK3 |
0.780 | 0.438 | -3 | 0.735 |
DLK |
0.780 | 0.007 | 1 | 0.816 |
LATS1 |
0.780 | 0.146 | -3 | 0.719 |
HIPK2 |
0.780 | 0.118 | 1 | 0.454 |
ANKRD3 |
0.780 | 0.061 | 1 | 0.853 |
MLK4 |
0.779 | 0.089 | 2 | 0.779 |
SSTK |
0.778 | 0.159 | 4 | 0.805 |
MASTL |
0.778 | -0.108 | -2 | 0.631 |
DYRK1A |
0.778 | 0.133 | 1 | 0.601 |
MAPKAPK2 |
0.778 | 0.083 | -3 | 0.654 |
GRK5 |
0.777 | -0.101 | -3 | 0.775 |
GRK1 |
0.777 | -0.004 | -2 | 0.570 |
DAPK1 |
0.777 | 0.425 | -3 | 0.737 |
DCAMKL1 |
0.775 | 0.156 | -3 | 0.691 |
YSK4 |
0.775 | 0.036 | 1 | 0.777 |
CDK5 |
0.775 | 0.042 | 1 | 0.541 |
CAMK1D |
0.775 | 0.220 | -3 | 0.656 |
CHK2 |
0.774 | 0.214 | -3 | 0.622 |
IKKA |
0.774 | -0.105 | -2 | 0.548 |
CDK8 |
0.774 | -0.047 | 1 | 0.533 |
DRAK1 |
0.773 | 0.104 | 1 | 0.767 |
MARK3 |
0.773 | 0.040 | 4 | 0.749 |
CDK19 |
0.773 | -0.035 | 1 | 0.495 |
CAMK1A |
0.773 | 0.257 | -3 | 0.619 |
DYRK1B |
0.772 | 0.121 | 1 | 0.504 |
TTBK2 |
0.772 | -0.087 | 2 | 0.677 |
CDK7 |
0.772 | -0.020 | 1 | 0.528 |
PLK1 |
0.771 | -0.018 | -2 | 0.607 |
LOK |
0.771 | 0.261 | -2 | 0.682 |
CRIK |
0.771 | 0.377 | -3 | 0.660 |
CDK14 |
0.771 | 0.094 | 1 | 0.508 |
GRK6 |
0.771 | -0.055 | 1 | 0.799 |
DMPK1 |
0.771 | 0.450 | -3 | 0.702 |
CDK13 |
0.771 | -0.001 | 1 | 0.498 |
CDK9 |
0.771 | 0.008 | 1 | 0.515 |
CAMK2A |
0.770 | 0.050 | 2 | 0.692 |
MAPKAPK5 |
0.770 | 0.044 | -3 | 0.718 |
NEK5 |
0.770 | 0.125 | 1 | 0.806 |
BUB1 |
0.770 | 0.201 | -5 | 0.672 |
MEKK1 |
0.769 | 0.073 | 1 | 0.815 |
MARK2 |
0.769 | 0.017 | 4 | 0.725 |
ZAK |
0.769 | 0.063 | 1 | 0.809 |
CDK12 |
0.769 | 0.018 | 1 | 0.475 |
MARK1 |
0.768 | 0.023 | 4 | 0.779 |
DCAMKL2 |
0.768 | 0.105 | -3 | 0.727 |
VRK2 |
0.767 | 0.054 | 1 | 0.808 |
MEK5 |
0.767 | 0.072 | 2 | 0.811 |
TNIK |
0.767 | 0.241 | 3 | 0.844 |
NEK4 |
0.767 | 0.182 | 1 | 0.801 |
HPK1 |
0.767 | 0.235 | 1 | 0.793 |
KHS2 |
0.767 | 0.268 | 1 | 0.797 |
CAMK2B |
0.767 | 0.003 | 2 | 0.667 |
NEK8 |
0.766 | 0.168 | 2 | 0.851 |
KIS |
0.766 | -0.063 | 1 | 0.561 |
TAO2 |
0.766 | 0.185 | 2 | 0.850 |
HGK |
0.766 | 0.206 | 3 | 0.841 |
MEKK6 |
0.766 | 0.204 | 1 | 0.775 |
MEK1 |
0.766 | -0.056 | 2 | 0.776 |
HRI |
0.766 | 0.000 | -2 | 0.612 |
PERK |
0.766 | -0.011 | -2 | 0.568 |
MAK |
0.766 | 0.163 | -2 | 0.724 |
CDK18 |
0.766 | -0.005 | 1 | 0.453 |
SMG1 |
0.766 | -0.040 | 1 | 0.690 |
PLK4 |
0.765 | -0.014 | 2 | 0.640 |
TAO3 |
0.765 | 0.110 | 1 | 0.777 |
KHS1 |
0.765 | 0.241 | 1 | 0.791 |
CK1E |
0.765 | 0.032 | -3 | 0.558 |
IRAK1 |
0.764 | -0.001 | -1 | 0.708 |
BRAF |
0.764 | 0.012 | -4 | 0.760 |
CDK6 |
0.764 | 0.079 | 1 | 0.490 |
MINK |
0.763 | 0.187 | 1 | 0.814 |
MEKK2 |
0.763 | 0.036 | 2 | 0.807 |
CDK4 |
0.763 | 0.076 | 1 | 0.456 |
MPSK1 |
0.763 | 0.093 | 1 | 0.713 |
CDK1 |
0.763 | -0.008 | 1 | 0.478 |
YSK1 |
0.763 | 0.229 | 2 | 0.842 |
DNAPK |
0.763 | -0.007 | 1 | 0.659 |
ATM |
0.763 | -0.068 | 1 | 0.688 |
PINK1 |
0.763 | -0.012 | 1 | 0.707 |
NEK1 |
0.762 | 0.238 | 1 | 0.802 |
GCK |
0.762 | 0.161 | 1 | 0.799 |
EEF2K |
0.762 | 0.182 | 3 | 0.829 |
ERK1 |
0.762 | -0.022 | 1 | 0.491 |
MOK |
0.762 | 0.156 | 1 | 0.582 |
MEKK3 |
0.762 | -0.028 | 1 | 0.804 |
ERK7 |
0.762 | 0.159 | 2 | 0.680 |
NEK11 |
0.762 | 0.074 | 1 | 0.803 |
SLK |
0.761 | 0.138 | -2 | 0.602 |
CK1G1 |
0.761 | 0.028 | -3 | 0.550 |
CDK2 |
0.761 | -0.004 | 1 | 0.573 |
P38A |
0.761 | -0.023 | 1 | 0.572 |
ERK2 |
0.760 | -0.028 | 1 | 0.522 |
PDK1 |
0.760 | 0.134 | 1 | 0.805 |
DYRK4 |
0.760 | 0.068 | 1 | 0.474 |
ALK4 |
0.760 | -0.100 | -2 | 0.570 |
CAMKK1 |
0.759 | 0.014 | -2 | 0.600 |
CDK17 |
0.759 | -0.026 | 1 | 0.400 |
MAP3K15 |
0.759 | 0.112 | 1 | 0.782 |
GRK4 |
0.759 | -0.176 | -2 | 0.581 |
CHK1 |
0.759 | -0.044 | -3 | 0.688 |
LKB1 |
0.758 | 0.081 | -3 | 0.766 |
CDK3 |
0.758 | 0.033 | 1 | 0.416 |
LRRK2 |
0.758 | 0.177 | 2 | 0.855 |
STK33 |
0.758 | 0.039 | 2 | 0.604 |
CAMKK2 |
0.757 | 0.035 | -2 | 0.614 |
BMPR1B |
0.757 | -0.054 | 1 | 0.744 |
NEK3 |
0.757 | 0.145 | 1 | 0.775 |
CK1A2 |
0.756 | 0.060 | -3 | 0.531 |
JNK2 |
0.756 | -0.032 | 1 | 0.486 |
RIPK2 |
0.754 | 0.042 | 1 | 0.786 |
PBK |
0.754 | 0.140 | 1 | 0.724 |
PRP4 |
0.753 | -0.026 | -3 | 0.643 |
PLK3 |
0.753 | -0.105 | 2 | 0.693 |
MYO3B |
0.753 | 0.257 | 2 | 0.858 |
ACVR2A |
0.753 | -0.107 | -2 | 0.534 |
GAK |
0.753 | 0.105 | 1 | 0.786 |
JNK3 |
0.753 | -0.054 | 1 | 0.509 |
TAK1 |
0.752 | 0.104 | 1 | 0.807 |
FAM20C |
0.752 | -0.046 | 2 | 0.517 |
TTBK1 |
0.752 | -0.079 | 2 | 0.595 |
SBK |
0.751 | 0.133 | -3 | 0.573 |
P38G |
0.751 | -0.038 | 1 | 0.398 |
CK1D |
0.751 | 0.018 | -3 | 0.525 |
P38B |
0.751 | -0.046 | 1 | 0.495 |
GRK2 |
0.751 | -0.073 | -2 | 0.511 |
GRK7 |
0.751 | -0.066 | 1 | 0.698 |
TGFBR1 |
0.750 | -0.127 | -2 | 0.533 |
PASK |
0.750 | 0.022 | -3 | 0.760 |
CDK16 |
0.750 | -0.003 | 1 | 0.409 |
ACVR2B |
0.749 | -0.122 | -2 | 0.540 |
TLK2 |
0.748 | -0.171 | 1 | 0.742 |
HASPIN |
0.748 | 0.124 | -1 | 0.690 |
ALK2 |
0.747 | -0.124 | -2 | 0.533 |
MST2 |
0.747 | -0.016 | 1 | 0.810 |
TAO1 |
0.745 | 0.151 | 1 | 0.738 |
MST1 |
0.745 | 0.035 | 1 | 0.803 |
TLK1 |
0.744 | -0.150 | -2 | 0.564 |
MYO3A |
0.743 | 0.167 | 1 | 0.774 |
VRK1 |
0.742 | 0.032 | 2 | 0.786 |
P38D |
0.742 | -0.047 | 1 | 0.415 |
MEK2 |
0.740 | -0.034 | 2 | 0.775 |
BMPR1A |
0.740 | -0.087 | 1 | 0.732 |
OSR1 |
0.737 | 0.052 | 2 | 0.795 |
ASK1 |
0.736 | 0.075 | 1 | 0.765 |
GSK3B |
0.736 | -0.037 | 4 | 0.369 |
GRK3 |
0.734 | -0.086 | -2 | 0.463 |
BIKE |
0.733 | 0.096 | 1 | 0.674 |
TTK |
0.731 | 0.017 | -2 | 0.599 |
YANK3 |
0.728 | 0.006 | 2 | 0.361 |
GSK3A |
0.727 | -0.054 | 4 | 0.380 |
LIMK2_TYR |
0.726 | 0.233 | -3 | 0.781 |
TNNI3K_TYR |
0.724 | 0.253 | 1 | 0.821 |
TESK1_TYR |
0.723 | 0.133 | 3 | 0.802 |
CK2A2 |
0.721 | -0.090 | 1 | 0.627 |
PKMYT1_TYR |
0.720 | 0.085 | 3 | 0.759 |
PINK1_TYR |
0.720 | 0.142 | 1 | 0.767 |
PLK2 |
0.719 | -0.129 | -3 | 0.659 |
JNK1 |
0.719 | -0.102 | 1 | 0.456 |
PDHK3_TYR |
0.718 | -0.006 | 4 | 0.878 |
AAK1 |
0.717 | 0.103 | 1 | 0.573 |
TYK2 |
0.717 | 0.097 | 1 | 0.786 |
LIMK1_TYR |
0.717 | 0.111 | 2 | 0.840 |
MAP2K7_TYR |
0.716 | 0.015 | 2 | 0.820 |
RET |
0.714 | 0.119 | 1 | 0.779 |
ROS1 |
0.714 | 0.081 | 3 | 0.687 |
CK1A |
0.714 | -0.025 | -3 | 0.447 |
MAP2K4_TYR |
0.713 | -0.078 | -1 | 0.781 |
TNK1 |
0.713 | 0.152 | 3 | 0.690 |
TYRO3 |
0.712 | 0.039 | 3 | 0.719 |
CK2A1 |
0.712 | -0.097 | 1 | 0.610 |
STLK3 |
0.712 | -0.083 | 1 | 0.771 |
PDHK4_TYR |
0.710 | -0.075 | 2 | 0.819 |
DDR1 |
0.709 | 0.068 | 4 | 0.828 |
MST1R |
0.709 | 0.026 | 3 | 0.700 |
JAK2 |
0.709 | 0.012 | 1 | 0.790 |
NEK10_TYR |
0.709 | 0.070 | 1 | 0.643 |
PDGFRB |
0.708 | 0.069 | 3 | 0.712 |
JAK1 |
0.708 | 0.099 | 1 | 0.763 |
MAP2K6_TYR |
0.708 | -0.133 | -1 | 0.787 |
EPHA6 |
0.708 | 0.050 | -1 | 0.725 |
BMPR2_TYR |
0.707 | -0.064 | -1 | 0.760 |
ALPHAK3 |
0.706 | -0.114 | -1 | 0.679 |
WEE1_TYR |
0.705 | 0.084 | -1 | 0.668 |
PDHK1_TYR |
0.703 | -0.171 | -1 | 0.769 |
CSF1R |
0.702 | -0.046 | 3 | 0.699 |
FLT3 |
0.702 | 0.012 | 3 | 0.709 |
TNK2 |
0.702 | -0.002 | 3 | 0.625 |
JAK3 |
0.701 | -0.018 | 1 | 0.758 |
CK1G3 |
0.701 | 0.000 | -3 | 0.412 |
PDGFRA |
0.701 | 0.009 | 3 | 0.721 |
EPHB4 |
0.700 | -0.043 | -1 | 0.714 |
ABL2 |
0.699 | -0.031 | -1 | 0.675 |
FGR |
0.699 | -0.075 | 1 | 0.816 |
KDR |
0.697 | 0.021 | 3 | 0.641 |
DDR2 |
0.695 | 0.115 | 3 | 0.609 |
ABL1 |
0.695 | -0.047 | -1 | 0.665 |
AXL |
0.695 | -0.036 | 3 | 0.644 |
ALK |
0.694 | -0.017 | 3 | 0.613 |
ITK |
0.693 | -0.066 | -1 | 0.695 |
FER |
0.693 | -0.139 | 1 | 0.806 |
YANK2 |
0.693 | -0.050 | 2 | 0.378 |
YES1 |
0.692 | -0.083 | -1 | 0.715 |
INSRR |
0.692 | -0.098 | 3 | 0.633 |
BTK |
0.692 | -0.074 | -1 | 0.669 |
TXK |
0.692 | -0.058 | 1 | 0.799 |
LTK |
0.691 | -0.025 | 3 | 0.624 |
HCK |
0.691 | -0.105 | -1 | 0.699 |
TEC |
0.690 | -0.047 | -1 | 0.620 |
TEK |
0.689 | -0.085 | 3 | 0.619 |
KIT |
0.689 | -0.114 | 3 | 0.690 |
EPHA1 |
0.689 | -0.013 | 3 | 0.626 |
PTK6 |
0.688 | -0.113 | -1 | 0.637 |
FGFR2 |
0.688 | -0.095 | 3 | 0.651 |
LCK |
0.688 | -0.063 | -1 | 0.694 |
MERTK |
0.688 | -0.067 | 3 | 0.642 |
EPHB1 |
0.688 | -0.110 | 1 | 0.822 |
EPHB3 |
0.687 | -0.106 | -1 | 0.693 |
BMX |
0.685 | -0.069 | -1 | 0.603 |
SRMS |
0.685 | -0.164 | 1 | 0.810 |
FGFR1 |
0.685 | -0.115 | 3 | 0.634 |
EPHA4 |
0.684 | -0.125 | 2 | 0.681 |
BLK |
0.683 | -0.073 | -1 | 0.688 |
FLT4 |
0.683 | -0.080 | 3 | 0.636 |
NTRK2 |
0.683 | -0.120 | 3 | 0.640 |
FLT1 |
0.682 | -0.085 | -1 | 0.707 |
INSR |
0.682 | -0.109 | 3 | 0.616 |
NTRK1 |
0.682 | -0.151 | -1 | 0.695 |
EPHB2 |
0.681 | -0.138 | -1 | 0.677 |
MET |
0.680 | -0.137 | 3 | 0.662 |
EPHA7 |
0.679 | -0.090 | 2 | 0.708 |
FRK |
0.678 | -0.124 | -1 | 0.695 |
ERBB2 |
0.677 | -0.161 | 1 | 0.739 |
PTK2B |
0.674 | -0.100 | -1 | 0.644 |
EPHA3 |
0.674 | -0.161 | 2 | 0.681 |
FGFR3 |
0.673 | -0.148 | 3 | 0.619 |
LYN |
0.673 | -0.152 | 3 | 0.623 |
MUSK |
0.673 | -0.065 | 1 | 0.632 |
FYN |
0.672 | -0.119 | -1 | 0.661 |
NTRK3 |
0.672 | -0.159 | -1 | 0.645 |
MATK |
0.670 | -0.124 | -1 | 0.589 |
CSK |
0.667 | -0.176 | 2 | 0.712 |
EPHA5 |
0.665 | -0.157 | 2 | 0.679 |
CK1G2 |
0.665 | -0.071 | -3 | 0.484 |
SRC |
0.663 | -0.165 | -1 | 0.649 |
IGF1R |
0.663 | -0.133 | 3 | 0.543 |
EGFR |
0.661 | -0.153 | 1 | 0.659 |
PTK2 |
0.661 | -0.094 | -1 | 0.675 |
EPHA8 |
0.660 | -0.171 | -1 | 0.656 |
SYK |
0.656 | -0.129 | -1 | 0.640 |
FGFR4 |
0.656 | -0.183 | -1 | 0.634 |
EPHA2 |
0.652 | -0.160 | -1 | 0.635 |
FES |
0.648 | -0.158 | -1 | 0.569 |
ERBB4 |
0.645 | -0.154 | 1 | 0.659 |
ZAP70 |
0.639 | -0.114 | -1 | 0.583 |