Motif 416 (n=99)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5PKW4 | PSD | S191 | ochoa | PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) | Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}. |
| A6NDB9 | PALM3 | S143 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| C9JH25 | PRRT4 | S641 | ochoa | Proline-rich transmembrane protein 4 | None |
| O14639 | ABLIM1 | S632 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14654 | IRS4 | S457 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15015 | ZNF646 | S521 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O15047 | SETD1A | S220 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15062 | ZBTB5 | S516 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O15211 | RGL2 | S736 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O43432 | EIF4G3 | S1131 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43683 | BUB1 | S679 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O75112 | LDB3 | S77 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75146 | HIP1R | S1027 | ochoa | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}. |
| O75676 | RPS6KA4 | S634 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O75962 | TRIO | S2440 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94804 | STK10 | S392 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94953 | KDM4B | S1039 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95208 | EPN2 | S504 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95758 | PTBP3 | S159 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| P02042 | HBD | S50 | ochoa | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | Involved in oxygen transport from the lung to the various peripheral tissues. |
| P05114 | HMGN1 | S21 | ochoa|psp | Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}. |
| P12882 | MYH1 | S668 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S664 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13535 | MYH8 | S667 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P38936 | CDKN1A | S114 | psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P41250 | GARS1 | S35 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P48751 | SLC4A3 | S170 | ochoa | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| P49792 | RANBP2 | S1128 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P56945 | BCAR1 | S428 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P62753 | RPS6 | S53 | ochoa | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P68871 | HBB | S50 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| P78332 | RBM6 | S52 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P78348 | ASIC1 | S487 | ochoa | Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) | Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). {ECO:0000250|UniProtKB:Q6NXK8, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:32915133, ECO:0000269|PubMed:34319232}.; FUNCTION: [Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium. {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster (PubMed:21036899). Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present (PubMed:21036899). Also potentially permeable to lithium and potassium (PubMed:21036899). {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro. {ECO:0000269|PubMed:21036899}. |
| P78358 | CTAG1A | S108 | ochoa | Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) | None |
| P78559 | MAP1A | S2225 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q02952 | AKAP12 | S371 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q12929 | EPS8 | S476 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13017 | ARHGAP5 | S540 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q14451 | GRB7 | S411 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q15084 | PDIA6 | S394 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15477 | SKIC2 | S255 | ochoa | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}. |
| Q1W6H9 | FAM110C | S121 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q5T1M5 | FKBP15 | S1024 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T7B8 | KIF24 | S1021 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5THJ4 | VPS13D | S2682 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5THJ4 | VPS13D | S2684 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q6P0N0 | MIS18BP1 | S894 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6T4P5 | PLPPR3 | S353 | ochoa | Phospholipid phosphatase-related protein type 3 (Inactive phospholipid phosphatase PLPPR3) (Lipid phosphate phosphatase-related protein type 3) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2) | None |
| Q6ZRV2 | FAM83H | S411 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q765P7 | MTSS2 | S639 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7L591 | DOK3 | S364 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7RTP6 | MICAL3 | S1337 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z6I6 | ARHGAP30 | S1067 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86UD0 | SAPCD2 | S276 | ochoa | Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) | Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}. |
| Q86UX7 | FERMT3 | S478 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86VR2 | RETREG3 | S325 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86VZ1 | P2RY8 | S324 | ochoa | S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8) | G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed:25274307, PubMed:30842656, PubMed:34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed:25274307, PubMed:30842656, PubMed:34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed:30842656, PubMed:34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed:25274307). {ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:30842656, ECO:0000269|PubMed:34088745}. |
| Q8N8K9 | KIAA1958 | S288 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NBR6 | MINDY2 | S62 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
| Q8NC44 | RETREG2 | S402 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8ND82 | ZNF280C | S515 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
| Q8TEJ3 | SH3RF3 | S381 | ochoa | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}. |
| Q8WV24 | PHLDA1 | S95 | psp | Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein) | Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. {ECO:0000269|PubMed:11369516, ECO:0000269|PubMed:12738777}. |
| Q92616 | GCN1 | S1491 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q96A59 | MARVELD3 | S113 | ochoa | MARVEL domain-containing protein 3 | As a component of tight junctions, plays a role in paracellular ion conductivity. {ECO:0000269|PubMed:20028514}. |
| Q96GY0 | ZC2HC1A | S243 | ochoa | Zinc finger C2HC domain-containing protein 1A | None |
| Q96J92 | WNK4 | S331 | ochoa | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
| Q96PC5 | MIA2 | S1243 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96RT6 | CTAGE1 | S604 | ochoa | cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) | None |
| Q9BQS8 | FYCO1 | S579 | ochoa | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| Q9BRD0 | BUD13 | S281 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BTC0 | DIDO1 | S1327 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUH8 | BEGAIN | S500 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BW04 | SARG | S149 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BYP7 | WNK3 | S304 | ochoa | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9BZ29 | DOCK9 | S1221 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C0C2 | TNKS1BP1 | S1473 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZM8 | NDEL1 | S215 | ochoa | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9H4A3 | WNK1 | S378 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H8V3 | ECT2 | S879 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NRL3 | STRN4 | S206 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
| Q9P203 | BTBD7 | S956 | ochoa | BTB/POZ domain-containing protein 7 | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}. |
| Q9P273 | TENM3 | S207 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9UBW5 | BIN2 | S411 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UKX2 | MYH2 | S670 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S668 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UPV0 | CEP164 | S270 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y2H9 | MAST1 | S1306 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y3S1 | WNK2 | S352 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y623 | MYH4 | S668 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| O00141 | SGK1 | S252 | Sugiyama | Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. {ECO:0000269|PubMed:11154281, ECO:0000269|PubMed:11410590, ECO:0000269|PubMed:11696533, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12761204, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15234985, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15733869, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16443776, ECO:0000269|PubMed:16982696, ECO:0000269|PubMed:17382906, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:18753299, ECO:0000269|PubMed:19447520, ECO:0000269|PubMed:19756449, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:20730100, ECO:0000269|PubMed:21865597}. |
| O14920 | IKBKB | S682 | SIGNOR|ELM|EPSD | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| P33316 | DUT | S120 | Sugiyama | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}. |
| O15146 | MUSK | S531 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
| P24928 | POLR2A | S35 | Sugiyama | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| Q9H0C5 | BTBD1 | S273 | Sugiyama | BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8) | Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250|UniProtKB:P58544, ECO:0000269|PubMed:14528312}. |
| P78371 | CCT2 | S438 | Sugiyama | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P08174 | CD55 | S54 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| Q9H2X6 | HIPK2 | S955 | Sugiyama | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.000011 | 4.953 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.000011 | 4.953 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.000199 | 3.702 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.000384 | 3.415 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.000520 | 3.284 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.000520 | 3.284 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.000721 | 3.142 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.000825 | 3.084 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.000913 | 3.039 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.001089 | 2.963 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.001128 | 2.948 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.001453 | 2.838 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.001588 | 2.799 |
| R-HSA-1640170 | Cell Cycle | 0.001584 | 2.800 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.002545 | 2.594 |
| R-HSA-983712 | Ion channel transport | 0.003318 | 2.479 |
| R-HSA-68877 | Mitotic Prometaphase | 0.003638 | 2.439 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.007403 | 2.131 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.007403 | 2.131 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.007309 | 2.136 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.007804 | 2.108 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.008803 | 2.055 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.009449 | 2.025 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.009554 | 2.020 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.009554 | 2.020 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.010123 | 1.995 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.011359 | 1.945 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.013353 | 1.874 |
| R-HSA-69275 | G2/M Transition | 0.014111 | 1.850 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.014656 | 1.834 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.015208 | 1.818 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.018526 | 1.732 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.018876 | 1.724 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.020469 | 1.689 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.020469 | 1.689 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.020533 | 1.688 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.020892 | 1.680 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.022045 | 1.657 |
| R-HSA-68882 | Mitotic Anaphase | 0.024188 | 1.616 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.024574 | 1.610 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.027199 | 1.565 |
| R-HSA-186763 | Downstream signal transduction | 0.027319 | 1.564 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.031508 | 1.502 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.031559 | 1.501 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.040523 | 1.392 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.047116 | 1.327 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.085746 | 1.067 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.110633 | 0.956 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.134848 | 0.870 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.140799 | 0.851 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.152580 | 0.817 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.164200 | 0.785 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.175663 | 0.755 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.181335 | 0.742 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.181335 | 0.742 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.186969 | 0.728 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.203642 | 0.691 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.203642 | 0.691 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.209124 | 0.680 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.209124 | 0.680 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.209124 | 0.680 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.209124 | 0.680 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.214568 | 0.668 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.086670 | 1.062 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.086670 | 1.062 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.219976 | 0.658 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.092933 | 1.032 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.225346 | 0.647 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.225346 | 0.647 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.235977 | 0.627 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.235977 | 0.627 |
| R-HSA-390522 | Striated Muscle Contraction | 0.241239 | 0.618 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.241239 | 0.618 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.108027 | 0.966 |
| R-HSA-380287 | Centrosome maturation | 0.112453 | 0.949 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.251654 | 0.599 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.272061 | 0.565 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.277076 | 0.557 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.277076 | 0.557 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.144633 | 0.840 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.287003 | 0.542 |
| R-HSA-167161 | HIV Transcription Initiation | 0.287003 | 0.542 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.287003 | 0.542 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.296795 | 0.528 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.306454 | 0.514 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.306454 | 0.514 |
| R-HSA-774815 | Nucleosome assembly | 0.306454 | 0.514 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.311234 | 0.507 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.311234 | 0.507 |
| R-HSA-167169 | HIV Transcription Elongation | 0.277076 | 0.557 |
| R-HSA-72086 | mRNA Capping | 0.214568 | 0.668 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.277076 | 0.557 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.225346 | 0.647 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.272061 | 0.565 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.142273 | 0.847 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.246464 | 0.608 |
| R-HSA-6798695 | Neutrophil degranulation | 0.113410 | 0.945 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.134848 | 0.870 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.302218 | 0.520 |
| R-HSA-174577 | Activation of C3 and C5 | 0.047116 | 1.327 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.277076 | 0.557 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.315982 | 0.500 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.043800 | 1.359 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.301641 | 0.521 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.128856 | 0.890 |
| R-HSA-391251 | Protein folding | 0.156552 | 0.805 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.304754 | 0.516 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.053665 | 1.270 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.098274 | 1.008 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.110633 | 0.956 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.110633 | 0.956 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.122823 | 0.911 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.152580 | 0.817 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.181335 | 0.742 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.186969 | 0.728 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.082570 | 1.083 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.261927 | 0.582 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.306454 | 0.514 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.146709 | 0.834 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.301641 | 0.521 |
| R-HSA-69236 | G1 Phase | 0.301641 | 0.521 |
| R-HSA-9927020 | Heme assimilation | 0.134848 | 0.870 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.235977 | 0.627 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.105832 | 0.975 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.241239 | 0.618 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.117947 | 0.928 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.122823 | 0.911 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.152580 | 0.817 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.152580 | 0.817 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.084613 | 1.073 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.219976 | 0.658 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.246464 | 0.608 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.132921 | 0.876 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.311234 | 0.507 |
| R-HSA-977606 | Regulation of Complement cascade | 0.248779 | 0.604 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.246464 | 0.608 |
| R-HSA-166658 | Complement cascade | 0.309822 | 0.509 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.066629 | 1.176 |
| R-HSA-425381 | Bicarbonate transporters | 0.092032 | 1.036 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.104475 | 0.981 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.104475 | 0.981 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.116749 | 0.933 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.152580 | 0.817 |
| R-HSA-429947 | Deadenylation of mRNA | 0.186969 | 0.728 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.225346 | 0.647 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.277076 | 0.557 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.277076 | 0.557 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.277076 | 0.557 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.282056 | 0.550 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.188321 | 0.725 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.122823 | 0.911 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.314882 | 0.502 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.152580 | 0.817 |
| R-HSA-5260271 | Diseases of Immune System | 0.277076 | 0.557 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.277076 | 0.557 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.092032 | 1.036 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 0.122823 | 0.911 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.158410 | 0.800 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.203642 | 0.691 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.078533 | 1.105 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.230680 | 0.637 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.267011 | 0.573 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.311234 | 0.507 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.146709 | 0.834 |
| R-HSA-5617833 | Cilium Assembly | 0.057213 | 1.243 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.053665 | 1.270 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.104475 | 0.981 |
| R-HSA-5578768 | Physiological factors | 0.116749 | 0.933 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.140799 | 0.851 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.272061 | 0.565 |
| R-HSA-373752 | Netrin-1 signaling | 0.050509 | 1.297 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.282056 | 0.550 |
| R-HSA-168255 | Influenza Infection | 0.157129 | 0.804 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.251654 | 0.599 |
| R-HSA-73886 | Chromosome Maintenance | 0.238611 | 0.622 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.175663 | 0.755 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.192565 | 0.715 |
| R-HSA-354192 | Integrin signaling | 0.235977 | 0.627 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.112453 | 0.949 |
| R-HSA-68886 | M Phase | 0.060789 | 1.216 |
| R-HSA-3214842 | HDMs demethylate histones | 0.192565 | 0.715 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.104475 | 0.981 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.104475 | 0.981 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.116749 | 0.933 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.306454 | 0.514 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.302218 | 0.520 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.208128 | 0.682 |
| R-HSA-9629569 | Protein hydroxylation | 0.158410 | 0.800 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.256808 | 0.590 |
| R-HSA-211000 | Gene Silencing by RNA | 0.198273 | 0.703 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.089745 | 1.047 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.244681 | 0.611 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.251654 | 0.599 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.243693 | 0.613 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.272061 | 0.565 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.169951 | 0.770 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.301641 | 0.521 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.311234 | 0.507 |
| R-HSA-210993 | Tie2 Signaling | 0.146709 | 0.834 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.175663 | 0.755 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.235977 | 0.627 |
| R-HSA-437239 | Recycling pathway of L1 | 0.315982 | 0.500 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.050509 | 1.297 |
| R-HSA-73887 | Death Receptor Signaling | 0.031709 | 1.499 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.192565 | 0.715 |
| R-HSA-186797 | Signaling by PDGF | 0.084613 | 1.073 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.171090 | 0.767 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.041034 | 1.387 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.051558 | 1.288 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.181335 | 0.742 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.246464 | 0.608 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.256808 | 0.590 |
| R-HSA-8939211 | ESR-mediated signaling | 0.261270 | 0.583 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.267011 | 0.573 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.277076 | 0.557 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.291916 | 0.535 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.116465 | 0.934 |
| R-HSA-8853659 | RET signaling | 0.256808 | 0.590 |
| R-HSA-422475 | Axon guidance | 0.096932 | 1.014 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.032367 | 1.490 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.035933 | 1.445 |
| R-HSA-9675108 | Nervous system development | 0.123638 | 0.908 |
| R-HSA-165159 | MTOR signalling | 0.291916 | 0.535 |
| R-HSA-162582 | Signal Transduction | 0.094698 | 1.024 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.235977 | 0.627 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.296795 | 0.528 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.233536 | 0.632 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.139922 | 0.854 |
| R-HSA-109582 | Hemostasis | 0.191869 | 0.717 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.165971 | 0.780 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.154153 | 0.812 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.292059 | 0.535 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.320697 | 0.494 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.320697 | 0.494 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.322458 | 0.492 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.330030 | 0.481 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.332527 | 0.478 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.334649 | 0.475 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.339237 | 0.469 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.339237 | 0.469 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.339237 | 0.469 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.339989 | 0.469 |
| R-HSA-162587 | HIV Life Cycle | 0.340052 | 0.468 |
| R-HSA-9711097 | Cellular response to starvation | 0.342555 | 0.465 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.343793 | 0.464 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.343793 | 0.464 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.343793 | 0.464 |
| R-HSA-1221632 | Meiotic synapsis | 0.343793 | 0.464 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.347552 | 0.459 |
| R-HSA-72649 | Translation initiation complex formation | 0.348318 | 0.458 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.348318 | 0.458 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.352812 | 0.452 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.357275 | 0.447 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.357275 | 0.447 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.357275 | 0.447 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.357275 | 0.447 |
| R-HSA-75893 | TNF signaling | 0.357275 | 0.447 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.361708 | 0.442 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.366111 | 0.436 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.366111 | 0.436 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.370483 | 0.431 |
| R-HSA-191859 | snRNP Assembly | 0.370483 | 0.431 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.370483 | 0.431 |
| R-HSA-379724 | tRNA Aminoacylation | 0.374826 | 0.426 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.374826 | 0.426 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.379139 | 0.421 |
| R-HSA-450294 | MAP kinase activation | 0.379139 | 0.421 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.383422 | 0.416 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.383422 | 0.416 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.383422 | 0.416 |
| R-HSA-9707616 | Heme signaling | 0.383422 | 0.416 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.383422 | 0.416 |
| R-HSA-382551 | Transport of small molecules | 0.386914 | 0.412 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.387676 | 0.412 |
| R-HSA-8848021 | Signaling by PTK6 | 0.387676 | 0.412 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.387676 | 0.412 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.391901 | 0.407 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.391901 | 0.407 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.396097 | 0.402 |
| R-HSA-2559583 | Cellular Senescence | 0.399172 | 0.399 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.404404 | 0.393 |
| R-HSA-167172 | Transcription of the HIV genome | 0.408514 | 0.389 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.408514 | 0.389 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.408514 | 0.389 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.412805 | 0.384 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.416651 | 0.380 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.416651 | 0.380 |
| R-HSA-448424 | Interleukin-17 signaling | 0.416651 | 0.380 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.416651 | 0.380 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.420678 | 0.376 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.420678 | 0.376 |
| R-HSA-9638482 | Metal ion assimilation from the host | 0.420678 | 0.376 |
| R-HSA-3000178 | ECM proteoglycans | 0.420678 | 0.376 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.420678 | 0.376 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.424677 | 0.372 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.424677 | 0.372 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.424677 | 0.372 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.424677 | 0.372 |
| R-HSA-2262752 | Cellular responses to stress | 0.426166 | 0.370 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.427832 | 0.369 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.428649 | 0.368 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.432541 | 0.364 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.432594 | 0.364 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.432594 | 0.364 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.436512 | 0.360 |
| R-HSA-9609690 | HCMV Early Events | 0.437230 | 0.359 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.444522 | 0.352 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.448105 | 0.349 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.451170 | 0.346 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.451917 | 0.345 |
| R-HSA-9659379 | Sensory processing of sound | 0.451917 | 0.345 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.453474 | 0.343 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.455702 | 0.341 |
| R-HSA-9833482 | PKR-mediated signaling | 0.455702 | 0.341 |
| R-HSA-72172 | mRNA Splicing | 0.458067 | 0.339 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.463196 | 0.334 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.463196 | 0.334 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.466904 | 0.331 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.468912 | 0.329 |
| R-HSA-1500620 | Meiosis | 0.474244 | 0.324 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.474244 | 0.324 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.474244 | 0.324 |
| R-HSA-397014 | Muscle contraction | 0.476217 | 0.322 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.478460 | 0.320 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.481485 | 0.317 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.481485 | 0.317 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.481485 | 0.317 |
| R-HSA-156902 | Peptide chain elongation | 0.488627 | 0.311 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.492161 | 0.308 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.493497 | 0.307 |
| R-HSA-202424 | Downstream TCR signaling | 0.495671 | 0.305 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.495671 | 0.305 |
| R-HSA-8951664 | Neddylation | 0.496195 | 0.304 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.499157 | 0.302 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.502619 | 0.299 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.506057 | 0.296 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.506057 | 0.296 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.507087 | 0.295 |
| R-HSA-162906 | HIV Infection | 0.509247 | 0.293 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.516231 | 0.287 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.516231 | 0.287 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.519576 | 0.284 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.519576 | 0.284 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.519576 | 0.284 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.522898 | 0.282 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.522898 | 0.282 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.524196 | 0.281 |
| R-HSA-157579 | Telomere Maintenance | 0.526198 | 0.279 |
| R-HSA-913531 | Interferon Signaling | 0.529309 | 0.276 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.529475 | 0.276 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.529475 | 0.276 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.529475 | 0.276 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.529475 | 0.276 |
| R-HSA-190236 | Signaling by FGFR | 0.529475 | 0.276 |
| R-HSA-70171 | Glycolysis | 0.535961 | 0.271 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.539171 | 0.268 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.539171 | 0.268 |
| R-HSA-8953854 | Metabolism of RNA | 0.542236 | 0.266 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.542358 | 0.266 |
| R-HSA-192823 | Viral mRNA Translation | 0.545524 | 0.263 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.548669 | 0.261 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.548669 | 0.261 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.551791 | 0.258 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.551791 | 0.258 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.554893 | 0.256 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.554893 | 0.256 |
| R-HSA-4839726 | Chromatin organization | 0.555199 | 0.256 |
| R-HSA-9609646 | HCMV Infection | 0.557215 | 0.254 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.557973 | 0.253 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.561032 | 0.251 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.564070 | 0.249 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.564070 | 0.249 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.564070 | 0.249 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.564070 | 0.249 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.567087 | 0.246 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.570083 | 0.244 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.570083 | 0.244 |
| R-HSA-202403 | TCR signaling | 0.570083 | 0.244 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.576014 | 0.240 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.576014 | 0.240 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.576014 | 0.240 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.578949 | 0.237 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.581864 | 0.235 |
| R-HSA-166663 | Initial triggering of complement | 0.584759 | 0.233 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.584759 | 0.233 |
| R-HSA-416476 | G alpha (q) signalling events | 0.584764 | 0.233 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.587635 | 0.231 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.590490 | 0.229 |
| R-HSA-168249 | Innate Immune System | 0.591193 | 0.228 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.592403 | 0.227 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.593326 | 0.227 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.593326 | 0.227 |
| R-HSA-373760 | L1CAM interactions | 0.593326 | 0.227 |
| R-HSA-70326 | Glucose metabolism | 0.596142 | 0.225 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.598939 | 0.223 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.601717 | 0.221 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.601717 | 0.221 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.603666 | 0.219 |
| R-HSA-68875 | Mitotic Prophase | 0.604476 | 0.219 |
| R-HSA-3371556 | Cellular response to heat stress | 0.607216 | 0.217 |
| R-HSA-1266738 | Developmental Biology | 0.608295 | 0.216 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.609937 | 0.215 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.609937 | 0.215 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.615323 | 0.211 |
| R-HSA-69206 | G1/S Transition | 0.620635 | 0.207 |
| R-HSA-194138 | Signaling by VEGF | 0.620635 | 0.207 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.620635 | 0.207 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.620635 | 0.207 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.620635 | 0.207 |
| R-HSA-114608 | Platelet degranulation | 0.625875 | 0.204 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.628468 | 0.202 |
| R-HSA-1474165 | Reproduction | 0.636140 | 0.196 |
| R-HSA-5576891 | Cardiac conduction | 0.638662 | 0.195 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.641251 | 0.193 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.643655 | 0.191 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.658227 | 0.182 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.662952 | 0.179 |
| R-HSA-9664407 | Parasite infection | 0.662952 | 0.179 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.662952 | 0.179 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.665290 | 0.177 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.674483 | 0.171 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.678985 | 0.168 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.681549 | 0.167 |
| R-HSA-199991 | Membrane Trafficking | 0.681721 | 0.166 |
| R-HSA-69242 | S Phase | 0.683426 | 0.165 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.683426 | 0.165 |
| R-HSA-166520 | Signaling by NTRKs | 0.683426 | 0.165 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.686976 | 0.163 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.687805 | 0.163 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.689973 | 0.161 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.692125 | 0.160 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.692125 | 0.160 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.692125 | 0.160 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.694262 | 0.158 |
| R-HSA-9612973 | Autophagy | 0.700587 | 0.155 |
| R-HSA-9610379 | HCMV Late Events | 0.702666 | 0.153 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.704731 | 0.152 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.715232 | 0.146 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.716826 | 0.145 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.722307 | 0.141 |
| R-HSA-5619102 | SLC transporter disorders | 0.722687 | 0.141 |
| R-HSA-372790 | Signaling by GPCR | 0.729428 | 0.137 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.730317 | 0.136 |
| R-HSA-72306 | tRNA processing | 0.730317 | 0.136 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.732191 | 0.135 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.737738 | 0.132 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.739561 | 0.131 |
| R-HSA-73894 | DNA Repair | 0.740018 | 0.131 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.762153 | 0.118 |
| R-HSA-9679506 | SARS-CoV Infections | 0.762854 | 0.118 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.767084 | 0.115 |
| R-HSA-212436 | Generic Transcription Pathway | 0.767287 | 0.115 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.770211 | 0.113 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.785816 | 0.105 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.785816 | 0.105 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.812830 | 0.090 |
| R-HSA-72766 | Translation | 0.819697 | 0.086 |
| R-HSA-74160 | Gene expression (Transcription) | 0.822249 | 0.085 |
| R-HSA-72312 | rRNA processing | 0.826366 | 0.083 |
| R-HSA-449147 | Signaling by Interleukins | 0.826819 | 0.083 |
| R-HSA-15869 | Metabolism of nucleotides | 0.831162 | 0.080 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.832341 | 0.080 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.843687 | 0.074 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.847682 | 0.072 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.860278 | 0.065 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.876864 | 0.057 |
| R-HSA-9658195 | Leishmania infection | 0.876864 | 0.057 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.877726 | 0.057 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.880157 | 0.055 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.883595 | 0.054 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.889184 | 0.051 |
| R-HSA-597592 | Post-translational protein modification | 0.903189 | 0.044 |
| R-HSA-9824446 | Viral Infection Pathways | 0.903754 | 0.044 |
| R-HSA-1474244 | Extracellular matrix organization | 0.913382 | 0.039 |
| R-HSA-388396 | GPCR downstream signalling | 0.915792 | 0.038 |
| R-HSA-500792 | GPCR ligand binding | 0.926143 | 0.033 |
| R-HSA-168256 | Immune System | 0.930315 | 0.031 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.943293 | 0.025 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.944875 | 0.025 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.946033 | 0.024 |
| R-HSA-5663205 | Infectious disease | 0.957486 | 0.019 |
| R-HSA-392499 | Metabolism of proteins | 0.957785 | 0.019 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.964228 | 0.016 |
| R-HSA-112316 | Neuronal System | 0.967385 | 0.014 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.988830 | 0.005 |
| R-HSA-1280218 | Adaptive Immune System | 0.995602 | 0.002 |
| R-HSA-1643685 | Disease | 0.996797 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999880 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.812 | 0.601 | -2 | 0.868 |
PAK6 |
0.805 | 0.596 | -2 | 0.859 |
AURB |
0.797 | 0.594 | -2 | 0.870 |
AURA |
0.796 | 0.595 | -2 | 0.890 |
PKACB |
0.793 | 0.484 | -2 | 0.840 |
PRKX |
0.788 | 0.414 | -3 | 0.677 |
PKACA |
0.788 | 0.472 | -2 | 0.833 |
MSK1 |
0.786 | 0.421 | -3 | 0.689 |
PKACG |
0.785 | 0.412 | -2 | 0.774 |
MNK2 |
0.785 | 0.471 | -2 | 0.796 |
PAK4 |
0.784 | 0.553 | -2 | 0.869 |
RSK2 |
0.784 | 0.267 | -3 | 0.731 |
PAK5 |
0.783 | 0.550 | -2 | 0.846 |
PKG2 |
0.782 | 0.468 | -2 | 0.805 |
CLK3 |
0.781 | 0.229 | 1 | 0.543 |
PRKD2 |
0.781 | 0.221 | -3 | 0.778 |
CLK4 |
0.779 | 0.367 | -3 | 0.726 |
CLK2 |
0.778 | 0.294 | -3 | 0.704 |
PAK1 |
0.777 | 0.457 | -2 | 0.825 |
PAK3 |
0.776 | 0.465 | -2 | 0.808 |
PRKD1 |
0.776 | 0.158 | -3 | 0.801 |
RSK3 |
0.775 | 0.246 | -3 | 0.715 |
CLK1 |
0.775 | 0.298 | -3 | 0.731 |
SKMLCK |
0.774 | 0.379 | -2 | 0.754 |
MNK1 |
0.773 | 0.401 | -2 | 0.784 |
MYLK4 |
0.772 | 0.433 | -2 | 0.832 |
P90RSK |
0.771 | 0.184 | -3 | 0.723 |
MSK2 |
0.771 | 0.307 | -3 | 0.676 |
NDR2 |
0.771 | 0.107 | -3 | 0.789 |
RSK4 |
0.770 | 0.264 | -3 | 0.697 |
CAMLCK |
0.770 | 0.446 | -2 | 0.776 |
PIM3 |
0.769 | 0.117 | -3 | 0.762 |
NDR1 |
0.769 | 0.197 | -3 | 0.787 |
CAMK1B |
0.769 | 0.231 | -3 | 0.801 |
CDC7 |
0.768 | 0.025 | 1 | 0.593 |
AKT2 |
0.768 | 0.296 | -3 | 0.663 |
IKKE |
0.768 | 0.145 | 1 | 0.668 |
IKKB |
0.767 | 0.025 | -2 | 0.499 |
COT |
0.767 | -0.033 | 2 | 0.672 |
TBK1 |
0.766 | 0.117 | 1 | 0.666 |
PAK2 |
0.766 | 0.460 | -2 | 0.824 |
CAMK2D |
0.766 | 0.102 | -3 | 0.802 |
WNK1 |
0.765 | 0.205 | -2 | 0.647 |
MTOR |
0.765 | 0.023 | 1 | 0.626 |
MAPKAPK3 |
0.765 | 0.125 | -3 | 0.760 |
RAF1 |
0.765 | 0.168 | 1 | 0.679 |
SRPK1 |
0.765 | 0.090 | -3 | 0.688 |
SGK3 |
0.765 | 0.313 | -3 | 0.737 |
MST4 |
0.765 | 0.167 | 2 | 0.666 |
DAPK2 |
0.765 | 0.379 | -3 | 0.804 |
P70S6KB |
0.765 | 0.230 | -3 | 0.753 |
CAMK4 |
0.764 | 0.289 | -3 | 0.789 |
PKN3 |
0.763 | 0.131 | -3 | 0.767 |
AKT1 |
0.763 | 0.364 | -3 | 0.693 |
PKN2 |
0.763 | 0.206 | -3 | 0.798 |
LATS2 |
0.761 | 0.074 | -5 | 0.708 |
PIM1 |
0.761 | 0.134 | -3 | 0.730 |
CAMK2G |
0.761 | 0.025 | 2 | 0.673 |
PRKD3 |
0.761 | 0.171 | -3 | 0.732 |
PDHK4 |
0.760 | 0.016 | 1 | 0.658 |
CAMK2A |
0.759 | 0.106 | 2 | 0.692 |
NLK |
0.759 | 0.073 | 1 | 0.596 |
MAPKAPK2 |
0.759 | 0.069 | -3 | 0.702 |
PKCD |
0.759 | 0.205 | 2 | 0.580 |
ERK5 |
0.758 | 0.029 | 1 | 0.619 |
HIPK4 |
0.758 | 0.077 | 1 | 0.504 |
ICK |
0.758 | 0.121 | -3 | 0.769 |
CHAK2 |
0.757 | 0.062 | -1 | 0.771 |
RIPK3 |
0.757 | 0.123 | 3 | 0.705 |
AMPKA1 |
0.756 | 0.119 | -3 | 0.824 |
DSTYK |
0.756 | -0.047 | 2 | 0.701 |
PRPK |
0.756 | -0.098 | -1 | 0.734 |
NIK |
0.756 | 0.203 | -3 | 0.816 |
CAMK2B |
0.756 | 0.072 | 2 | 0.666 |
AMPKA2 |
0.755 | 0.118 | -3 | 0.802 |
ATR |
0.755 | 0.042 | 1 | 0.569 |
TSSK1 |
0.754 | 0.128 | -3 | 0.845 |
NUAK2 |
0.754 | 0.043 | -3 | 0.802 |
PDHK1 |
0.754 | 0.043 | 1 | 0.658 |
TSSK2 |
0.754 | 0.126 | -5 | 0.828 |
PKG1 |
0.754 | 0.408 | -2 | 0.792 |
DNAPK |
0.754 | 0.102 | 1 | 0.587 |
HUNK |
0.753 | 0.013 | 2 | 0.658 |
GCN2 |
0.753 | -0.124 | 2 | 0.655 |
CDKL1 |
0.752 | 0.018 | -3 | 0.723 |
IKKA |
0.752 | -0.031 | -2 | 0.459 |
ULK2 |
0.752 | -0.091 | 2 | 0.603 |
NEK6 |
0.752 | -0.035 | -2 | 0.566 |
AKT3 |
0.752 | 0.298 | -3 | 0.604 |
CDKL5 |
0.752 | 0.023 | -3 | 0.727 |
TGFBR2 |
0.752 | -0.004 | -2 | 0.552 |
MOS |
0.751 | -0.062 | 1 | 0.591 |
DYRK2 |
0.751 | 0.069 | 1 | 0.463 |
SRPK2 |
0.750 | 0.061 | -3 | 0.611 |
NEK2 |
0.750 | 0.154 | 2 | 0.641 |
LATS1 |
0.749 | 0.137 | -3 | 0.786 |
MELK |
0.749 | 0.099 | -3 | 0.795 |
BCKDK |
0.749 | 0.005 | -1 | 0.691 |
MARK4 |
0.749 | -0.002 | 4 | 0.708 |
DYRK3 |
0.749 | 0.243 | 1 | 0.464 |
PIM2 |
0.749 | 0.160 | -3 | 0.714 |
BMPR2 |
0.749 | -0.104 | -2 | 0.582 |
GRK6 |
0.749 | 0.018 | 1 | 0.631 |
GRK1 |
0.749 | -0.009 | -2 | 0.536 |
HIPK2 |
0.747 | 0.092 | 1 | 0.390 |
NEK7 |
0.747 | -0.084 | -3 | 0.758 |
WNK3 |
0.747 | 0.066 | 1 | 0.617 |
PLK1 |
0.747 | 0.018 | -2 | 0.553 |
ULK1 |
0.746 | -0.101 | -3 | 0.739 |
NIM1 |
0.746 | 0.009 | 3 | 0.746 |
KIS |
0.746 | -0.008 | 1 | 0.459 |
PKCG |
0.746 | 0.138 | 2 | 0.528 |
GRK5 |
0.746 | -0.075 | -3 | 0.728 |
NEK9 |
0.745 | -0.029 | 2 | 0.649 |
DYRK4 |
0.745 | 0.081 | 1 | 0.410 |
SMMLCK |
0.745 | 0.345 | -3 | 0.763 |
QSK |
0.745 | 0.058 | 4 | 0.669 |
PKCZ |
0.745 | 0.150 | 2 | 0.581 |
PKCA |
0.745 | 0.156 | 2 | 0.519 |
RIPK1 |
0.745 | 0.042 | 1 | 0.596 |
SGK1 |
0.745 | 0.246 | -3 | 0.577 |
HIPK1 |
0.744 | 0.113 | 1 | 0.469 |
DAPK1 |
0.744 | 0.379 | -3 | 0.735 |
PKCH |
0.744 | 0.159 | 2 | 0.513 |
MRCKB |
0.744 | 0.374 | -3 | 0.720 |
MRCKA |
0.744 | 0.364 | -3 | 0.728 |
DAPK3 |
0.743 | 0.378 | -3 | 0.760 |
P70S6K |
0.743 | 0.154 | -3 | 0.668 |
CDK7 |
0.743 | 0.000 | 1 | 0.449 |
CHK1 |
0.743 | 0.056 | -3 | 0.793 |
JNK2 |
0.743 | 0.009 | 1 | 0.445 |
SRPK3 |
0.742 | 0.042 | -3 | 0.636 |
PKCI |
0.742 | 0.236 | 2 | 0.545 |
PKCB |
0.742 | 0.078 | 2 | 0.534 |
HIPK3 |
0.742 | 0.122 | 1 | 0.497 |
MASTL |
0.742 | -0.123 | -2 | 0.545 |
PHKG1 |
0.741 | 0.066 | -3 | 0.792 |
DCAMKL1 |
0.741 | 0.111 | -3 | 0.780 |
DLK |
0.741 | -0.055 | 1 | 0.624 |
CDK13 |
0.741 | -0.002 | 1 | 0.437 |
CDK19 |
0.741 | -0.032 | 1 | 0.409 |
QIK |
0.740 | 0.024 | -3 | 0.795 |
BRSK1 |
0.740 | 0.031 | -3 | 0.762 |
SMG1 |
0.740 | 0.038 | 1 | 0.527 |
TGFBR1 |
0.740 | -0.035 | -2 | 0.489 |
CDK8 |
0.739 | -0.049 | 1 | 0.432 |
FAM20C |
0.739 | -0.012 | 2 | 0.512 |
BMPR1B |
0.739 | -0.016 | 1 | 0.596 |
ALK4 |
0.739 | -0.030 | -2 | 0.524 |
PHKG2 |
0.739 | 0.158 | -3 | 0.796 |
CDK18 |
0.739 | -0.000 | 1 | 0.402 |
NUAK1 |
0.739 | -0.003 | -3 | 0.764 |
MEK1 |
0.738 | 0.029 | 2 | 0.727 |
DRAK1 |
0.738 | 0.053 | 1 | 0.655 |
CAMK1D |
0.738 | 0.161 | -3 | 0.683 |
MLK1 |
0.738 | -0.113 | 2 | 0.617 |
CDK9 |
0.738 | -0.002 | 1 | 0.452 |
PKCT |
0.738 | 0.201 | 2 | 0.519 |
DCAMKL2 |
0.738 | 0.097 | -3 | 0.804 |
CDK12 |
0.737 | 0.016 | 1 | 0.425 |
DYRK1A |
0.737 | 0.064 | 1 | 0.492 |
CDK14 |
0.737 | 0.066 | 1 | 0.445 |
MAPKAPK5 |
0.737 | 0.010 | -3 | 0.657 |
MLK2 |
0.736 | -0.088 | 2 | 0.655 |
CAMK1G |
0.736 | 0.094 | -3 | 0.720 |
YSK4 |
0.736 | 0.002 | 1 | 0.632 |
P38A |
0.736 | -0.001 | 1 | 0.507 |
ATM |
0.736 | -0.042 | 1 | 0.523 |
SIK |
0.736 | 0.026 | -3 | 0.733 |
CHAK1 |
0.736 | 0.014 | 2 | 0.634 |
P38B |
0.736 | -0.007 | 1 | 0.469 |
GSK3B |
0.736 | 0.114 | 4 | 0.592 |
GRK7 |
0.736 | -0.011 | 1 | 0.587 |
BRSK2 |
0.735 | 0.005 | -3 | 0.800 |
PKN1 |
0.735 | 0.157 | -3 | 0.707 |
PKCE |
0.735 | 0.209 | 2 | 0.512 |
PLK4 |
0.735 | -0.003 | 2 | 0.486 |
PLK3 |
0.735 | -0.036 | 2 | 0.628 |
DYRK1B |
0.734 | 0.074 | 1 | 0.431 |
CDK1 |
0.733 | -0.017 | 1 | 0.435 |
ANKRD3 |
0.733 | -0.074 | 1 | 0.649 |
GRK4 |
0.733 | -0.126 | -2 | 0.532 |
MARK3 |
0.733 | 0.002 | 4 | 0.628 |
PKR |
0.733 | 0.020 | 1 | 0.578 |
CDK10 |
0.733 | 0.065 | 1 | 0.431 |
ROCK2 |
0.733 | 0.341 | -3 | 0.762 |
ERK1 |
0.733 | -0.021 | 1 | 0.463 |
SNRK |
0.733 | 0.037 | 2 | 0.505 |
ALK2 |
0.732 | -0.040 | -2 | 0.512 |
HPK1 |
0.732 | 0.266 | 1 | 0.708 |
ACVR2B |
0.732 | -0.040 | -2 | 0.523 |
DMPK1 |
0.731 | 0.380 | -3 | 0.745 |
IRE1 |
0.731 | -0.058 | 1 | 0.524 |
TTBK2 |
0.731 | -0.113 | 2 | 0.550 |
ACVR2A |
0.731 | -0.046 | -2 | 0.519 |
MST3 |
0.731 | 0.101 | 2 | 0.651 |
SSTK |
0.731 | 0.102 | 4 | 0.650 |
JNK3 |
0.730 | -0.032 | 1 | 0.456 |
CHK2 |
0.730 | 0.138 | -3 | 0.630 |
MAK |
0.730 | 0.090 | -2 | 0.596 |
CDK3 |
0.730 | 0.020 | 1 | 0.385 |
BUB1 |
0.730 | 0.202 | -5 | 0.744 |
WNK4 |
0.730 | 0.071 | -2 | 0.622 |
CDK5 |
0.730 | -0.020 | 1 | 0.455 |
MARK1 |
0.728 | -0.006 | 4 | 0.646 |
CAMK1A |
0.728 | 0.175 | -3 | 0.647 |
MARK2 |
0.727 | -0.027 | 4 | 0.594 |
LOK |
0.727 | 0.197 | -2 | 0.604 |
MLK3 |
0.727 | -0.099 | 2 | 0.547 |
CDK2 |
0.727 | -0.022 | 1 | 0.503 |
CDK17 |
0.727 | -0.032 | 1 | 0.373 |
P38G |
0.726 | -0.029 | 1 | 0.377 |
VRK2 |
0.726 | -0.100 | 1 | 0.599 |
LKB1 |
0.726 | 0.092 | -3 | 0.790 |
GCK |
0.726 | 0.178 | 1 | 0.693 |
ROCK1 |
0.726 | 0.357 | -3 | 0.732 |
ERK2 |
0.725 | -0.037 | 1 | 0.483 |
GSK3A |
0.725 | 0.078 | 4 | 0.600 |
KHS2 |
0.724 | 0.242 | 1 | 0.704 |
PASK |
0.724 | 0.016 | -3 | 0.770 |
CAMKK1 |
0.724 | -0.003 | -2 | 0.550 |
CAMKK2 |
0.724 | 0.042 | -2 | 0.565 |
NEK5 |
0.724 | -0.004 | 1 | 0.607 |
TLK2 |
0.723 | -0.085 | 1 | 0.558 |
KHS1 |
0.723 | 0.243 | 1 | 0.688 |
P38D |
0.723 | -0.018 | 1 | 0.364 |
GRK2 |
0.723 | -0.075 | -2 | 0.457 |
BRAF |
0.722 | -0.052 | -4 | 0.766 |
SBK |
0.722 | 0.089 | -3 | 0.564 |
SLK |
0.722 | 0.109 | -2 | 0.533 |
PRP4 |
0.722 | 0.004 | -3 | 0.725 |
TAO3 |
0.722 | 0.046 | 1 | 0.618 |
TNIK |
0.722 | 0.172 | 3 | 0.875 |
CRIK |
0.721 | 0.209 | -3 | 0.683 |
MEK5 |
0.721 | -0.041 | 2 | 0.667 |
BMPR1A |
0.720 | -0.051 | 1 | 0.563 |
HRI |
0.720 | -0.084 | -2 | 0.569 |
PDK1 |
0.720 | 0.088 | 1 | 0.647 |
MEKK3 |
0.720 | -0.076 | 1 | 0.630 |
NEK4 |
0.720 | 0.111 | 1 | 0.627 |
PERK |
0.720 | -0.102 | -2 | 0.560 |
CDK16 |
0.720 | -0.027 | 1 | 0.379 |
MINK |
0.719 | 0.145 | 1 | 0.671 |
NEK11 |
0.719 | 0.015 | 1 | 0.656 |
IRAK4 |
0.719 | -0.014 | 1 | 0.550 |
HGK |
0.718 | 0.115 | 3 | 0.860 |
MPSK1 |
0.718 | -0.017 | 1 | 0.503 |
NEK1 |
0.717 | 0.124 | 1 | 0.600 |
PINK1 |
0.716 | -0.093 | 1 | 0.519 |
MLK4 |
0.716 | -0.147 | 2 | 0.538 |
ZAK |
0.716 | -0.108 | 1 | 0.589 |
IRE2 |
0.715 | -0.091 | 2 | 0.516 |
TAO2 |
0.714 | 0.038 | 2 | 0.644 |
MOK |
0.714 | 0.046 | 1 | 0.491 |
MEKK1 |
0.714 | -0.102 | 1 | 0.591 |
CDK4 |
0.714 | 0.008 | 1 | 0.408 |
MEKK2 |
0.714 | -0.090 | 2 | 0.632 |
TLK1 |
0.713 | -0.103 | -2 | 0.519 |
TTBK1 |
0.713 | -0.079 | 2 | 0.467 |
ERK7 |
0.712 | -0.024 | 2 | 0.383 |
GAK |
0.712 | -0.004 | 1 | 0.592 |
NEK8 |
0.712 | -0.018 | 2 | 0.610 |
CK2A2 |
0.711 | -0.036 | 1 | 0.516 |
CDK6 |
0.710 | -0.011 | 1 | 0.425 |
GRK3 |
0.710 | -0.080 | -2 | 0.430 |
MEKK6 |
0.710 | 0.028 | 1 | 0.600 |
TAK1 |
0.710 | 0.055 | 1 | 0.646 |
MEK2 |
0.710 | 0.024 | 2 | 0.685 |
IRAK1 |
0.709 | -0.106 | -1 | 0.691 |
PBK |
0.709 | 0.032 | 1 | 0.534 |
STK33 |
0.707 | -0.044 | 2 | 0.469 |
CK2A1 |
0.707 | -0.025 | 1 | 0.511 |
JNK1 |
0.707 | -0.054 | 1 | 0.428 |
EEF2K |
0.706 | -0.019 | 3 | 0.835 |
MST2 |
0.706 | -0.038 | 1 | 0.664 |
LRRK2 |
0.706 | -0.014 | 2 | 0.656 |
MAP3K15 |
0.705 | -0.027 | 1 | 0.595 |
RIPK2 |
0.704 | -0.029 | 1 | 0.584 |
PLK2 |
0.704 | -0.063 | -3 | 0.620 |
MST1 |
0.703 | 0.007 | 1 | 0.656 |
CK1E |
0.703 | -0.098 | -3 | 0.415 |
YSK1 |
0.703 | 0.034 | 2 | 0.617 |
CK1G1 |
0.703 | -0.058 | -3 | 0.385 |
HASPIN |
0.702 | 0.101 | -1 | 0.742 |
CK1A2 |
0.701 | -0.041 | -3 | 0.371 |
NEK3 |
0.700 | -0.007 | 1 | 0.573 |
CK1D |
0.698 | -0.078 | -3 | 0.370 |
MYO3B |
0.696 | 0.098 | 2 | 0.641 |
PDHK3_TYR |
0.694 | 0.117 | 4 | 0.836 |
TAO1 |
0.692 | 0.045 | 1 | 0.578 |
VRK1 |
0.691 | -0.135 | 2 | 0.620 |
BIKE |
0.690 | -0.002 | 1 | 0.495 |
LIMK2_TYR |
0.688 | 0.163 | -3 | 0.845 |
MYO3A |
0.688 | 0.050 | 1 | 0.600 |
YANK3 |
0.686 | -0.031 | 2 | 0.297 |
OSR1 |
0.686 | -0.049 | 2 | 0.658 |
ASK1 |
0.685 | -0.040 | 1 | 0.579 |
TESK1_TYR |
0.682 | 0.009 | 3 | 0.855 |
AAK1 |
0.682 | 0.023 | 1 | 0.420 |
MAP2K4_TYR |
0.682 | -0.037 | -1 | 0.742 |
PDHK4_TYR |
0.681 | -0.014 | 2 | 0.719 |
MAP2K7_TYR |
0.680 | -0.018 | 2 | 0.691 |
MAP2K6_TYR |
0.679 | -0.080 | -1 | 0.739 |
TTK |
0.678 | -0.069 | -2 | 0.561 |
BMPR2_TYR |
0.676 | -0.052 | -1 | 0.713 |
NEK10_TYR |
0.676 | 0.101 | 1 | 0.550 |
PKMYT1_TYR |
0.675 | -0.099 | 3 | 0.813 |
PINK1_TYR |
0.675 | -0.067 | 1 | 0.599 |
DDR1 |
0.672 | 0.010 | 4 | 0.727 |
STLK3 |
0.671 | -0.081 | 1 | 0.571 |
PDHK1_TYR |
0.670 | -0.153 | -1 | 0.741 |
RET |
0.670 | 0.024 | 1 | 0.605 |
EPHA6 |
0.669 | -0.033 | -1 | 0.710 |
TYK2 |
0.668 | -0.025 | 1 | 0.611 |
TNK2 |
0.668 | 0.021 | 3 | 0.716 |
LIMK1_TYR |
0.667 | -0.083 | 2 | 0.668 |
MST1R |
0.667 | -0.025 | 3 | 0.784 |
EPHB4 |
0.667 | -0.057 | -1 | 0.709 |
TNK1 |
0.666 | 0.085 | 3 | 0.750 |
JAK2 |
0.666 | -0.031 | 1 | 0.615 |
CK1A |
0.666 | -0.091 | -3 | 0.276 |
TYRO3 |
0.665 | -0.065 | 3 | 0.769 |
ABL2 |
0.664 | -0.023 | -1 | 0.692 |
ROS1 |
0.664 | -0.044 | 3 | 0.736 |
ALPHAK3 |
0.664 | -0.149 | -1 | 0.622 |
JAK1 |
0.663 | 0.042 | 1 | 0.616 |
TXK |
0.661 | -0.055 | 1 | 0.629 |
CSF1R |
0.661 | -0.086 | 3 | 0.765 |
AXL |
0.660 | -0.019 | 3 | 0.733 |
MERTK |
0.660 | -0.018 | 3 | 0.739 |
ABL1 |
0.659 | -0.044 | -1 | 0.687 |
SRMS |
0.659 | -0.107 | 1 | 0.634 |
DDR2 |
0.659 | 0.050 | 3 | 0.687 |
EPHA4 |
0.659 | -0.089 | 2 | 0.625 |
EPHB1 |
0.658 | -0.079 | 1 | 0.631 |
INSRR |
0.658 | -0.097 | 3 | 0.705 |
JAK3 |
0.656 | -0.123 | 1 | 0.584 |
YES1 |
0.656 | -0.108 | -1 | 0.723 |
TNNI3K_TYR |
0.656 | -0.026 | 1 | 0.559 |
EPHB3 |
0.655 | -0.094 | -1 | 0.699 |
FER |
0.653 | -0.171 | 1 | 0.631 |
ITK |
0.653 | -0.118 | -1 | 0.688 |
FGR |
0.653 | -0.173 | 1 | 0.638 |
TEC |
0.653 | -0.052 | -1 | 0.659 |
PDGFRB |
0.653 | -0.124 | 3 | 0.773 |
HCK |
0.653 | -0.122 | -1 | 0.700 |
EPHB2 |
0.652 | -0.114 | -1 | 0.685 |
BMX |
0.652 | -0.068 | -1 | 0.629 |
PTK2B |
0.651 | -0.050 | -1 | 0.683 |
FGFR2 |
0.650 | -0.142 | 3 | 0.751 |
EPHA1 |
0.650 | -0.018 | 3 | 0.740 |
EPHA7 |
0.650 | -0.071 | 2 | 0.614 |
KIT |
0.649 | -0.142 | 3 | 0.762 |
BTK |
0.649 | -0.109 | -1 | 0.694 |
CK1G3 |
0.649 | -0.050 | -3 | 0.228 |
PDGFRA |
0.648 | -0.115 | 3 | 0.774 |
LCK |
0.648 | -0.107 | -1 | 0.693 |
LTK |
0.648 | -0.057 | 3 | 0.695 |
KDR |
0.647 | -0.094 | 3 | 0.729 |
BLK |
0.647 | -0.097 | -1 | 0.699 |
FLT3 |
0.647 | -0.138 | 3 | 0.768 |
WEE1_TYR |
0.647 | -0.068 | -1 | 0.657 |
EPHA3 |
0.647 | -0.111 | 2 | 0.588 |
NTRK1 |
0.646 | -0.151 | -1 | 0.675 |
YANK2 |
0.645 | -0.093 | 2 | 0.312 |
TEK |
0.645 | -0.151 | 3 | 0.693 |
ALK |
0.644 | -0.091 | 3 | 0.673 |
FGFR1 |
0.644 | -0.176 | 3 | 0.717 |
EPHA5 |
0.642 | -0.101 | 2 | 0.604 |
MET |
0.641 | -0.161 | 3 | 0.758 |
FLT1 |
0.640 | -0.152 | -1 | 0.657 |
NTRK3 |
0.640 | -0.143 | -1 | 0.636 |
NTRK2 |
0.640 | -0.165 | 3 | 0.706 |
FRK |
0.639 | -0.122 | -1 | 0.731 |
FGFR3 |
0.639 | -0.157 | 3 | 0.724 |
ERBB2 |
0.639 | -0.167 | 1 | 0.592 |
INSR |
0.638 | -0.164 | 3 | 0.683 |
PTK6 |
0.638 | -0.192 | -1 | 0.624 |
FYN |
0.636 | -0.142 | -1 | 0.653 |
FLT4 |
0.636 | -0.166 | 3 | 0.704 |
EPHA8 |
0.634 | -0.138 | -1 | 0.660 |
PTK2 |
0.633 | -0.094 | -1 | 0.597 |
CSK |
0.633 | -0.149 | 2 | 0.617 |
LYN |
0.632 | -0.164 | 3 | 0.666 |
MUSK |
0.631 | -0.108 | 1 | 0.508 |
EGFR |
0.630 | -0.148 | 1 | 0.520 |
EPHA2 |
0.629 | -0.117 | -1 | 0.624 |
SRC |
0.628 | -0.170 | -1 | 0.658 |
MATK |
0.627 | -0.154 | -1 | 0.619 |
FGFR4 |
0.626 | -0.152 | -1 | 0.619 |
SYK |
0.625 | -0.137 | -1 | 0.592 |
IGF1R |
0.622 | -0.163 | 3 | 0.615 |
CK1G2 |
0.621 | -0.105 | -3 | 0.312 |
ERBB4 |
0.619 | -0.140 | 1 | 0.538 |
FES |
0.612 | -0.156 | -1 | 0.590 |
ZAP70 |
0.605 | -0.118 | -1 | 0.535 |