Motif 415 (n=93)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1315 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00192 | ARVCF | S267 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O14641 | DVL2 | S651 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14907 | TAX1BP3 | S61 | ochoa | Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1) | May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:16855024, ECO:0000269|PubMed:21139582}. |
| O15015 | ZNF646 | S521 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O15350 | TP73 | S289 | psp | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O43248 | HOXC11 | S88 | ochoa | Homeobox protein Hox-C11 (Homeobox protein Hox-3H) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene. |
| O43491 | EPB41L2 | S402 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43491 | EPB41L2 | S627 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O75762 | TRPA1 | S317 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O75791 | GRAP2 | S164 | ochoa | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
| O94915 | FRYL | S1945 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O95104 | SCAF4 | S1004 | ochoa | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
| O95466 | FMNL1 | S921 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95671 | ASMTL | S223 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| P02671 | FGA | S549 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04049 | RAF1 | S497 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P08183 | ABCB1 | S671 | psp | ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) | Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:35507548, ECO:0000269|PubMed:35970996, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}. |
| P0DJD0 | RGPD1 | S1299 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1307 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10398 | ARAF | S458 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P15056 | BRAF | S605 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P15924 | DSP | S176 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P25054 | APC | S130 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P29017 | CD1C | S215 | ochoa | T-cell surface glycoprotein CD1c (CD antigen CD1c) | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10786796, ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:21167756}. |
| P36915 | GNL1 | S36 | ochoa | Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) | Possible regulatory or functional link with the histocompatibility cluster. |
| P47736 | RAP1GAP | S498 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49792 | RANBP2 | S2290 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P53396 | ACLY | S663 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P55072 | VCP | S746 | psp | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P57075 | UBASH3A | S372 | ochoa | Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}. |
| P57764 | GSDMD | S185 | ochoa | Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40] | [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). {ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216}.; FUNCTION: [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:28392147, PubMed:32820063, PubMed:34289345, PubMed:38040708, PubMed:38530158, PubMed:38599239). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1, CASP4 or CASP5 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216, PubMed:29898893, PubMed:36227980). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27281216, PubMed:27418190, PubMed:29898893, PubMed:33883744, PubMed:38040708, PubMed:38530158, PubMed:38599239). Gasdermin pores also allow the release of mature caspase-7 (CASP7) (By similarity). In some, but not all, cells types, pyroptosis is followed by pyroptotic cell death, which is caused by downstream activation of ninjurin-1 (NINJ1), which mediates membrane rupture (cytolysis) (PubMed:33472215, PubMed:37198476). Also forms pores in the mitochondrial membrane, resulting in release of mitochondrial DNA (mtDNA) into the cytosol (By similarity). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (By similarity). Required for mucosal tissue defense against enteric pathogens (By similarity). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin (PubMed:27281216). Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216). {ECO:0000250|UniProtKB:Q9D8T2, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:27418190, ECO:0000269|PubMed:28392147, ECO:0000269|PubMed:29898893, ECO:0000269|PubMed:32820063, ECO:0000269|PubMed:33472215, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:36227980, ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:38040708, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.; FUNCTION: [Gasdermin-D, p13]: Transcription coactivator produced by the cleavage by CASP3 or CASP7 in the upper small intestine in response to dietary antigens (By similarity). Required to maintain food tolerance in small intestine: translocates to the nucleus and acts as a coactivator for STAT1 to induce the transcription of CIITA and MHC class II molecules, which in turn induce type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:Q9D8T2}.; FUNCTION: [Gasdermin-D, p40]: Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35794369). {ECO:0000269|PubMed:35794369}. |
| Q07889 | SOS1 | S1203 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q12815 | TROAP | S156 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q13496 | MTM1 | S23 | ochoa | Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:10900271, PubMed:11001925, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:23818870, ECO:0000269|PubMed:9537414}. |
| Q14152 | EIF3A | S895 | ochoa | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q14160 | SCRIB | S1220 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14524 | SCN5A | S528 | psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14980 | NUMA1 | S1887 | ochoa|psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q2NKX8 | ERCC6L | S1098 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q32MZ4 | LRRFIP1 | S120 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q3V6T2 | CCDC88A | S1594 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q5JTZ5 | C9orf152 | S87 | ochoa | Uncharacterized protein C9orf152 | None |
| Q5THJ4 | VPS13D | S2455 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VUB5 | FAM171A1 | S824 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q7KZI7 | MARK2 | S493 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L576 | CYFIP1 | S583 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7L591 | DOK3 | S389 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S834 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3J3 | RGPD4 | S1315 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z418 | KCNK18 | S262 | psp | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:12754259, PubMed:15562060, PubMed:20871611, PubMed:22355750, PubMed:26919430, PubMed:30573346). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (PubMed:34702947). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity). {ECO:0000250|UniProtKB:Q6VV64, ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611, ECO:0000269|PubMed:22355750, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:34702947}. |
| Q86YV0 | RASAL3 | S231 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8N5H7 | SH2D3C | S359 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8NG31 | KNL1 | S1008 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TC26 | TMEM163 | S55 | ochoa | Transmembrane protein 163 | Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:31697912, ECO:0000269|PubMed:32492420, ECO:0000269|PubMed:35455965, ECO:0000269|PubMed:36204728}. |
| Q8WVQ1 | CANT1 | S21 | ochoa | Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107) | Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15006348, PubMed:15248776, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). {ECO:0000269|PubMed:12234496, ECO:0000269|PubMed:15006348, ECO:0000269|PubMed:15248776, ECO:0000269|PubMed:16835225, ECO:0000269|PubMed:22539336}. |
| Q96CF2 | CHMP4C | S210 | psp | Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515}. |
| Q96CP6 | GRAMD1A | S284 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96E09 | PABIR1 | S197 | ochoa | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) | Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}. |
| Q96F07 | CYFIP2 | S607 | ochoa | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}. |
| Q96FF7 | MISP3 | S174 | ochoa | Uncharacterized protein MISP3 (MISP family member 3) | None |
| Q96JY6 | PDLIM2 | S209 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q99081 | TCF12 | S47 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99959 | PKP2 | S172 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q99988 | GDF15 | S39 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BT25 | HAUS8 | S311 | psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BXS6 | NUSAP1 | S251 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9C0C2 | TNKS1BP1 | S851 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S872 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S893 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H1E3 | NUCKS1 | S50 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9NRA8 | EIF4ENIF1 | S120 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRY2 | INIP | S50 | ochoa | SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) (hSSBIP1) | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
| Q9NSY0 | NRBP2 | S361 | ochoa | Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16) | May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}. |
| Q9NWQ8 | PAG1 | S150 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NWZ8 | GEMIN8 | S185 | ochoa | Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}. |
| Q9NX94 | WBP1L | S199 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NZM5 | NOP53 | S74 | ochoa | Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) | Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}. |
| Q9P244 | LRFN1 | S672 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9UIG0 | BAZ1B | S1315 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9Y2G0 | EFR3B | S693 | ochoa | Protein EFR3 homolog B | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}. |
| Q9Y2H0 | DLGAP4 | S415 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2U5 | MAP3K2 | S153 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y3C5 | RNF11 | S25 | ochoa | RING finger protein 11 | Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. {ECO:0000269|PubMed:14755250}. |
| Q9Y3Y2 | CHTOP | S40 | ochoa | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}. |
| Q9Y3Y2 | CHTOP | S64 | ochoa | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}. |
| Q9Y4F5 | CEP170B | S721 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y5S2 | CDC42BPB | S868 | ochoa|psp | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y6J9 | TAF6L | S505 | ochoa | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha) | Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). {ECO:0000250|UniProtKB:Q8R2K4, ECO:0000305|PubMed:9674419}. |
| P23142 | FBLN1 | S246 | Sugiyama | Fibulin-1 (FIBL-1) | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. |
| P41235 | HNF4A | S265 | PSP | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| Q07352 | ZFP36L1 | S84 | Sugiyama | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}. |
| Q07157 | TJP1 | S1153 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.000037 | 4.432 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.000049 | 4.309 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.000049 | 4.309 |
| R-HSA-5620971 | Pyroptosis | 0.000066 | 4.179 |
| R-HSA-5357801 | Programmed Cell Death | 0.000086 | 4.064 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.000074 | 4.130 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.000177 | 3.751 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.000266 | 3.575 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.000266 | 3.575 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.000384 | 3.416 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.000384 | 3.416 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.000384 | 3.416 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.000384 | 3.416 |
| R-HSA-186712 | Regulation of beta-cell development | 0.000855 | 3.068 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.001171 | 2.931 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.001183 | 2.927 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.001183 | 2.927 |
| R-HSA-5218859 | Regulated Necrosis | 0.001357 | 2.867 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.001791 | 2.747 |
| R-HSA-5673000 | RAF activation | 0.002220 | 2.654 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.002209 | 2.656 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.002809 | 2.552 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.003245 | 2.489 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.003656 | 2.437 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.003665 | 2.436 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.003536 | 2.452 |
| R-HSA-75153 | Apoptotic execution phase | 0.004786 | 2.320 |
| R-HSA-109581 | Apoptosis | 0.005465 | 2.262 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.006191 | 2.208 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.006270 | 2.203 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.007043 | 2.152 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.008103 | 2.091 |
| R-HSA-2028269 | Signaling by Hippo | 0.008454 | 2.073 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.008284 | 2.082 |
| R-HSA-9831926 | Nephron development | 0.009203 | 2.036 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.009203 | 2.036 |
| R-HSA-392517 | Rap1 signalling | 0.009981 | 2.001 |
| R-HSA-6798695 | Neutrophil degranulation | 0.010013 | 1.999 |
| R-HSA-68877 | Mitotic Prometaphase | 0.010618 | 1.974 |
| R-HSA-1299344 | TWIK-related spinal cord K+ channel (TRESK) | 0.012344 | 1.909 |
| R-HSA-9830369 | Kidney development | 0.011680 | 1.933 |
| R-HSA-68886 | M Phase | 0.013046 | 1.885 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.013369 | 1.874 |
| R-HSA-68882 | Mitotic Anaphase | 0.016177 | 1.791 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.016444 | 1.784 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.018202 | 1.740 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.021146 | 1.675 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.021146 | 1.675 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.020312 | 1.692 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.020312 | 1.692 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.020568 | 1.687 |
| R-HSA-2424491 | DAP12 signaling | 0.021404 | 1.670 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.022520 | 1.647 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.024821 | 1.605 |
| R-HSA-354192 | Integrin signaling | 0.024821 | 1.605 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.027215 | 1.565 |
| R-HSA-187687 | Signalling to ERKs | 0.028445 | 1.546 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.027215 | 1.565 |
| R-HSA-8853659 | RET signaling | 0.029698 | 1.527 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.030031 | 1.522 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.027862 | 1.555 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.030578 | 1.515 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.060229 | 1.220 |
| R-HSA-112412 | SOS-mediated signalling | 0.060229 | 1.220 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.071837 | 1.144 |
| R-HSA-4839744 | Signaling by APC mutants | 0.083303 | 1.079 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.083303 | 1.079 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.083303 | 1.079 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.083303 | 1.079 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.088983 | 1.051 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.094628 | 1.024 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.094628 | 1.024 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.094628 | 1.024 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.094628 | 1.024 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.094628 | 1.024 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.094628 | 1.024 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.111357 | 0.953 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.111357 | 0.953 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.122340 | 0.912 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.127780 | 0.894 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.149211 | 0.826 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.154487 | 0.811 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.154487 | 0.811 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.154487 | 0.811 |
| R-HSA-191859 | snRNP Assembly | 0.065577 | 1.183 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.065577 | 1.183 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.200534 | 0.698 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.205494 | 0.687 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.205494 | 0.687 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.090736 | 1.042 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.108166 | 0.966 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.122285 | 0.913 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.141047 | 0.851 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.171320 | 0.766 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.116865 | 0.932 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.141047 | 0.851 |
| R-HSA-191650 | Regulation of gap junction activity | 0.036581 | 1.437 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.043363 | 1.363 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.116865 | 0.932 |
| R-HSA-9664420 | Killing mechanisms | 0.116865 | 0.932 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.171320 | 0.766 |
| R-HSA-4086400 | PCP/CE pathway | 0.100311 | 0.999 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.042548 | 1.371 |
| R-HSA-8851805 | MET activates RAS signaling | 0.094628 | 1.024 |
| R-HSA-74749 | Signal attenuation | 0.077588 | 1.110 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.032313 | 1.491 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.193551 | 0.713 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.210424 | 0.677 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.043363 | 1.363 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.193551 | 0.713 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.180162 | 0.744 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.036581 | 1.437 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.083303 | 1.079 |
| R-HSA-428540 | Activation of RAC1 | 0.088983 | 1.051 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.088983 | 1.051 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.088983 | 1.051 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.088983 | 1.051 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.111357 | 0.953 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.116865 | 0.932 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.122340 | 0.912 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.133188 | 0.876 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.149211 | 0.826 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.154487 | 0.811 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.170120 | 0.769 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.185468 | 0.732 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.190521 | 0.720 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.112153 | 0.950 |
| R-HSA-170968 | Frs2-mediated activation | 0.100239 | 0.999 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.191310 | 0.718 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.133188 | 0.876 |
| R-HSA-9620244 | Long-term potentiation | 0.175268 | 0.756 |
| R-HSA-3295583 | TRP channels | 0.180383 | 0.744 |
| R-HSA-169893 | Prolonged ERK activation events | 0.116865 | 0.932 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.060229 | 1.220 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.094628 | 1.024 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.205494 | 0.687 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.210424 | 0.677 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.030578 | 1.515 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.048478 | 1.314 |
| R-HSA-2161517 | Abacavir transmembrane transport | 0.054372 | 1.265 |
| R-HSA-170984 | ARMS-mediated activation | 0.071837 | 1.144 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.077588 | 1.110 |
| R-HSA-2172127 | DAP12 interactions | 0.041907 | 1.378 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.200534 | 0.698 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.211594 | 0.674 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.054059 | 1.267 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.037656 | 1.424 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.170120 | 0.769 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.175268 | 0.756 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.052350 | 1.281 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.094628 | 1.024 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.105815 | 0.975 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.111357 | 0.953 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.111357 | 0.953 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.127780 | 0.894 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.164941 | 0.783 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.185468 | 0.732 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.170120 | 0.769 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.133188 | 0.876 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.030578 | 1.515 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 0.048478 | 1.314 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.094628 | 1.024 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.111357 | 0.953 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.138562 | 0.858 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.154487 | 0.811 |
| R-HSA-429947 | Deadenylation of mRNA | 0.170120 | 0.769 |
| R-HSA-9839394 | TGFBR3 expression | 0.175268 | 0.756 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.185468 | 0.732 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.104218 | 0.982 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.104720 | 0.980 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.195543 | 0.709 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.200534 | 0.698 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.071837 | 1.144 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.127780 | 0.894 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.127780 | 0.894 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.138562 | 0.858 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.154487 | 0.811 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.159730 | 0.797 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.175268 | 0.756 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.190521 | 0.720 |
| R-HSA-9757110 | Prednisone ADME | 0.190521 | 0.720 |
| R-HSA-9610379 | HCMV Late Events | 0.095932 | 1.018 |
| R-HSA-448706 | Interleukin-1 processing | 0.071837 | 1.144 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.100239 | 0.999 |
| R-HSA-167044 | Signalling to RAS | 0.149211 | 0.826 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.040065 | 1.397 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.180383 | 0.744 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.111357 | 0.953 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.159730 | 0.797 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.149211 | 0.826 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.149211 | 0.826 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.195543 | 0.709 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.200534 | 0.698 |
| R-HSA-202403 | TCR signaling | 0.175732 | 0.755 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.092628 | 1.033 |
| R-HSA-5689877 | Josephin domain DUBs | 0.077588 | 1.110 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 0.077588 | 1.110 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.154487 | 0.811 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.164941 | 0.783 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.185468 | 0.732 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.151724 | 0.819 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.040471 | 1.393 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.030972 | 1.509 |
| R-HSA-210993 | Tie2 Signaling | 0.133188 | 0.876 |
| R-HSA-525793 | Myogenesis | 0.180383 | 0.744 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.190521 | 0.720 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.195543 | 0.709 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.043363 | 1.363 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.143903 | 0.842 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.118278 | 0.927 |
| R-HSA-9658195 | Leishmania infection | 0.118278 | 0.927 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.105815 | 0.975 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.104218 | 0.982 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.060094 | 1.221 |
| R-HSA-190236 | Signaling by FGFR | 0.147434 | 0.831 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.105815 | 0.975 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.060546 | 1.218 |
| R-HSA-186763 | Downstream signal transduction | 0.205494 | 0.687 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.171320 | 0.766 |
| R-HSA-177929 | Signaling by EGFR | 0.060546 | 1.218 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.105815 | 0.975 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.116865 | 0.932 |
| R-HSA-166520 | Signaling by NTRKs | 0.085109 | 1.070 |
| R-HSA-8876725 | Protein methylation | 0.111357 | 0.953 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.180383 | 0.744 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.154487 | 0.811 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.159730 | 0.797 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.185468 | 0.732 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.200534 | 0.698 |
| R-HSA-112316 | Neuronal System | 0.188382 | 0.725 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.040471 | 1.393 |
| R-HSA-9842663 | Signaling by LTK | 0.094628 | 1.024 |
| R-HSA-9678110 | Attachment and Entry | 0.116865 | 0.932 |
| R-HSA-2161522 | Abacavir ADME | 0.180383 | 0.744 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.100025 | 1.000 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.185468 | 0.732 |
| R-HSA-180292 | GAB1 signalosome | 0.133188 | 0.876 |
| R-HSA-9694614 | Attachment and Entry | 0.154487 | 0.811 |
| R-HSA-68875 | Mitotic Prophase | 0.202549 | 0.693 |
| R-HSA-168249 | Innate Immune System | 0.039652 | 1.402 |
| R-HSA-1640170 | Cell Cycle | 0.084035 | 1.076 |
| R-HSA-9754706 | Atorvastatin ADME | 0.116865 | 0.932 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.170120 | 0.769 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.195543 | 0.709 |
| R-HSA-162582 | Signal Transduction | 0.081019 | 1.091 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.159730 | 0.797 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.200363 | 0.698 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.159730 | 0.797 |
| R-HSA-9607240 | FLT3 Signaling | 0.036278 | 1.440 |
| R-HSA-3371556 | Cellular response to heat stress | 0.204806 | 0.689 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.067697 | 1.169 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.094628 | 1.024 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.078207 | 1.107 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.060546 | 1.218 |
| R-HSA-162906 | HIV Infection | 0.198779 | 0.702 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.133188 | 0.876 |
| R-HSA-9612973 | Autophagy | 0.094702 | 1.024 |
| R-HSA-162587 | HIV Life Cycle | 0.095932 | 1.018 |
| R-HSA-1632852 | Macroautophagy | 0.075963 | 1.119 |
| R-HSA-9679506 | SARS-CoV Infections | 0.067796 | 1.169 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.191310 | 0.718 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.120488 | 0.919 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.215324 | 0.667 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.215324 | 0.667 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.215324 | 0.667 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.215324 | 0.667 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.215324 | 0.667 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.215324 | 0.667 |
| R-HSA-194138 | Signaling by VEGF | 0.216132 | 0.665 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.220194 | 0.657 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.220194 | 0.657 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.225034 | 0.648 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.225034 | 0.648 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.229844 | 0.639 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.229844 | 0.639 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.229844 | 0.639 |
| R-HSA-5576891 | Cardiac conduction | 0.232082 | 0.634 |
| R-HSA-3371511 | HSF1 activation | 0.234624 | 0.630 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.234624 | 0.630 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.234624 | 0.630 |
| R-HSA-9609646 | HCMV Infection | 0.235912 | 0.627 |
| R-HSA-1266738 | Developmental Biology | 0.237070 | 0.625 |
| R-HSA-4641258 | Degradation of DVL | 0.239375 | 0.621 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.239375 | 0.621 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.239375 | 0.621 |
| R-HSA-1566948 | Elastic fibre formation | 0.244097 | 0.612 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.244097 | 0.612 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.245813 | 0.609 |
| R-HSA-163685 | Integration of energy metabolism | 0.245813 | 0.609 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.248790 | 0.604 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.248790 | 0.604 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.249116 | 0.604 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.250399 | 0.601 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.253454 | 0.596 |
| R-HSA-202433 | Generation of second messenger molecules | 0.253454 | 0.596 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.253454 | 0.596 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.253454 | 0.596 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.253454 | 0.596 |
| R-HSA-5260271 | Diseases of Immune System | 0.253454 | 0.596 |
| R-HSA-9646399 | Aggrephagy | 0.253454 | 0.596 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.253454 | 0.596 |
| R-HSA-9664407 | Parasite infection | 0.254987 | 0.593 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.254987 | 0.593 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.254987 | 0.593 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.257282 | 0.590 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.258089 | 0.588 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.258089 | 0.588 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.258089 | 0.588 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.258089 | 0.588 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.262696 | 0.581 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.267275 | 0.573 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.271825 | 0.566 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.275841 | 0.559 |
| R-HSA-774815 | Nucleosome assembly | 0.280842 | 0.552 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.280842 | 0.552 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.280842 | 0.552 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.280842 | 0.552 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.285309 | 0.545 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.285309 | 0.545 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.285309 | 0.545 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.285309 | 0.545 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.285309 | 0.545 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.291707 | 0.535 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.294160 | 0.531 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.294160 | 0.531 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.298546 | 0.525 |
| R-HSA-73893 | DNA Damage Bypass | 0.298546 | 0.525 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.298546 | 0.525 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.302904 | 0.519 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.302904 | 0.519 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.307235 | 0.513 |
| R-HSA-72187 | mRNA 3'-end processing | 0.311539 | 0.506 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.311539 | 0.506 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.311539 | 0.506 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.315818 | 0.501 |
| R-HSA-195721 | Signaling by WNT | 0.316422 | 0.500 |
| R-HSA-72649 | Translation initiation complex formation | 0.320069 | 0.495 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.320069 | 0.495 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.328495 | 0.483 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.328495 | 0.483 |
| R-HSA-112399 | IRS-mediated signalling | 0.332669 | 0.478 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.332669 | 0.478 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.332669 | 0.478 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.336817 | 0.473 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.337273 | 0.472 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.340939 | 0.467 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.340939 | 0.467 |
| R-HSA-1280218 | Adaptive Immune System | 0.343779 | 0.464 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.345036 | 0.462 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.345036 | 0.462 |
| R-HSA-168255 | Influenza Infection | 0.348547 | 0.458 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.349108 | 0.457 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.349108 | 0.457 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.349108 | 0.457 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.353155 | 0.452 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.353155 | 0.452 |
| R-HSA-186797 | Signaling by PDGF | 0.353155 | 0.452 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.353155 | 0.452 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.357177 | 0.447 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.357177 | 0.447 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.357521 | 0.447 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.361175 | 0.442 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.361175 | 0.442 |
| R-HSA-69275 | G2/M Transition | 0.364223 | 0.439 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.365147 | 0.438 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.368677 | 0.433 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.369096 | 0.433 |
| R-HSA-983712 | Ion channel transport | 0.370899 | 0.431 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.373019 | 0.428 |
| R-HSA-5663205 | Infectious disease | 0.374185 | 0.427 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.375335 | 0.426 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.384647 | 0.415 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.384647 | 0.415 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.384647 | 0.415 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.384647 | 0.415 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.388475 | 0.411 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.392279 | 0.406 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.392279 | 0.406 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.392279 | 0.406 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.396060 | 0.402 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.396060 | 0.402 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.399818 | 0.398 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.401677 | 0.396 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.401677 | 0.396 |
| R-HSA-380287 | Centrosome maturation | 0.403553 | 0.394 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.403553 | 0.394 |
| R-HSA-8852135 | Protein ubiquitination | 0.403553 | 0.394 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.403553 | 0.394 |
| R-HSA-6805567 | Keratinization | 0.410345 | 0.387 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.414619 | 0.382 |
| R-HSA-5619084 | ABC transporter disorders | 0.414619 | 0.382 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.414619 | 0.382 |
| R-HSA-216083 | Integrin cell surface interactions | 0.414619 | 0.382 |
| R-HSA-9824446 | Viral Infection Pathways | 0.421173 | 0.376 |
| R-HSA-6806834 | Signaling by MET | 0.421884 | 0.375 |
| R-HSA-397014 | Muscle contraction | 0.423233 | 0.373 |
| R-HSA-977225 | Amyloid fiber formation | 0.425483 | 0.371 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.436146 | 0.360 |
| R-HSA-8953854 | Metabolism of RNA | 0.440748 | 0.356 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.443146 | 0.353 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.450060 | 0.347 |
| R-HSA-156902 | Peptide chain elongation | 0.453485 | 0.343 |
| R-HSA-9663891 | Selective autophagy | 0.453485 | 0.343 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.456889 | 0.340 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.460272 | 0.337 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.463634 | 0.334 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.466975 | 0.331 |
| R-HSA-422475 | Axon guidance | 0.468553 | 0.329 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.470296 | 0.328 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.470296 | 0.328 |
| R-HSA-168256 | Immune System | 0.472136 | 0.326 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.473596 | 0.325 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.480136 | 0.319 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.483375 | 0.316 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.486595 | 0.313 |
| R-HSA-1296071 | Potassium Channels | 0.486595 | 0.313 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.492974 | 0.307 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.495361 | 0.305 |
| R-HSA-3214847 | HATs acetylate histones | 0.496135 | 0.304 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.496135 | 0.304 |
| R-HSA-70171 | Glycolysis | 0.499276 | 0.302 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.502397 | 0.299 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.505499 | 0.296 |
| R-HSA-1483255 | PI Metabolism | 0.505499 | 0.296 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.505499 | 0.296 |
| R-HSA-192823 | Viral mRNA Translation | 0.508582 | 0.294 |
| R-HSA-5688426 | Deubiquitination | 0.511047 | 0.292 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.511646 | 0.291 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.511646 | 0.291 |
| R-HSA-1643685 | Disease | 0.512009 | 0.291 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.512985 | 0.290 |
| R-HSA-9675108 | Nervous system development | 0.518067 | 0.286 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.523714 | 0.281 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.523714 | 0.281 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.523714 | 0.281 |
| R-HSA-211000 | Gene Silencing by RNA | 0.523714 | 0.281 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.526685 | 0.278 |
| R-HSA-72766 | Translation | 0.531926 | 0.274 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.538385 | 0.269 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.538385 | 0.269 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.538385 | 0.269 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.546971 | 0.262 |
| R-HSA-373760 | L1CAM interactions | 0.555400 | 0.255 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.556177 | 0.255 |
| R-HSA-70326 | Glucose metabolism | 0.558174 | 0.253 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.563673 | 0.249 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.563673 | 0.249 |
| R-HSA-73886 | Chromosome Maintenance | 0.569103 | 0.245 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.571794 | 0.243 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.571794 | 0.243 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.574467 | 0.241 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.577124 | 0.239 |
| R-HSA-114608 | Platelet degranulation | 0.587589 | 0.231 |
| R-HSA-199991 | Membrane Trafficking | 0.600721 | 0.221 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.605289 | 0.218 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.619860 | 0.208 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.631595 | 0.200 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.633899 | 0.198 |
| R-HSA-1474244 | Extracellular matrix organization | 0.643661 | 0.191 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.645205 | 0.190 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.649630 | 0.187 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.651821 | 0.186 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.654000 | 0.184 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.654000 | 0.184 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.654000 | 0.184 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.656165 | 0.183 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.658316 | 0.182 |
| R-HSA-73887 | Death Receptor Signaling | 0.658316 | 0.182 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.666789 | 0.176 |
| R-HSA-9711097 | Cellular response to starvation | 0.666789 | 0.176 |
| R-HSA-877300 | Interferon gamma signaling | 0.668875 | 0.175 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.670948 | 0.173 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.670948 | 0.173 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.679111 | 0.168 |
| R-HSA-5619102 | SLC transporter disorders | 0.685101 | 0.164 |
| R-HSA-73894 | DNA Repair | 0.686320 | 0.163 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.692917 | 0.159 |
| R-HSA-72306 | tRNA processing | 0.692917 | 0.159 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.694840 | 0.158 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.696752 | 0.157 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.698652 | 0.156 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.698652 | 0.156 |
| R-HSA-913531 | Interferon Signaling | 0.718419 | 0.144 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.725776 | 0.139 |
| R-HSA-5617833 | Cilium Assembly | 0.729204 | 0.137 |
| R-HSA-9609690 | HCMV Early Events | 0.739238 | 0.131 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.739238 | 0.131 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.745722 | 0.127 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.762631 | 0.118 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.765712 | 0.116 |
| R-HSA-9748784 | Drug ADME | 0.774406 | 0.111 |
| R-HSA-418990 | Adherens junctions interactions | 0.774406 | 0.111 |
| R-HSA-8951664 | Neddylation | 0.778632 | 0.109 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.789522 | 0.103 |
| R-HSA-72312 | rRNA processing | 0.793468 | 0.100 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.796058 | 0.099 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.799882 | 0.097 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.808074 | 0.093 |
| R-HSA-4839726 | Chromatin organization | 0.814483 | 0.089 |
| R-HSA-421270 | Cell-cell junction organization | 0.816811 | 0.088 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.817673 | 0.087 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.830188 | 0.081 |
| R-HSA-416476 | G alpha (q) signalling events | 0.831258 | 0.080 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.835472 | 0.078 |
| R-HSA-446728 | Cell junction organization | 0.845556 | 0.073 |
| R-HSA-1483257 | Phospholipid metabolism | 0.861314 | 0.065 |
| R-HSA-382551 | Transport of small molecules | 0.875691 | 0.058 |
| R-HSA-1500931 | Cell-Cell communication | 0.878598 | 0.056 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.881639 | 0.055 |
| R-HSA-109582 | Hemostasis | 0.881659 | 0.055 |
| R-HSA-74160 | Gene expression (Transcription) | 0.883278 | 0.054 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.883871 | 0.054 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.883871 | 0.054 |
| R-HSA-449147 | Signaling by Interleukins | 0.913679 | 0.039 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.917943 | 0.037 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.921201 | 0.036 |
| R-HSA-8978868 | Fatty acid metabolism | 0.932380 | 0.030 |
| R-HSA-212436 | Generic Transcription Pathway | 0.933603 | 0.030 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.938554 | 0.028 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.950240 | 0.022 |
| R-HSA-2262752 | Cellular responses to stress | 0.960106 | 0.018 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.978798 | 0.009 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.982562 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.993673 | 0.003 |
| R-HSA-597592 | Post-translational protein modification | 0.994500 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.996327 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.998557 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999396 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.811 | 0.714 | -2 | 0.814 |
AURB |
0.798 | 0.705 | -2 | 0.817 |
AURA |
0.794 | 0.691 | -2 | 0.861 |
PAK6 |
0.789 | 0.618 | -2 | 0.754 |
PKACB |
0.786 | 0.548 | -2 | 0.767 |
PAK4 |
0.781 | 0.628 | -2 | 0.809 |
PKACG |
0.780 | 0.486 | -2 | 0.648 |
PAK5 |
0.780 | 0.623 | -2 | 0.770 |
PKACA |
0.778 | 0.515 | -2 | 0.780 |
PKG2 |
0.778 | 0.534 | -2 | 0.715 |
PRKX |
0.777 | 0.454 | -3 | 0.598 |
MNK2 |
0.776 | 0.547 | -2 | 0.679 |
PAK1 |
0.771 | 0.552 | -2 | 0.703 |
MSK1 |
0.770 | 0.458 | -3 | 0.622 |
PAK3 |
0.767 | 0.544 | -2 | 0.675 |
MYLK4 |
0.763 | 0.490 | -2 | 0.714 |
MNK1 |
0.763 | 0.472 | -2 | 0.645 |
RSK2 |
0.763 | 0.283 | -3 | 0.648 |
PAK2 |
0.762 | 0.564 | -2 | 0.701 |
RSK3 |
0.761 | 0.288 | -3 | 0.628 |
MSK2 |
0.760 | 0.361 | -3 | 0.611 |
SKMLCK |
0.760 | 0.427 | -2 | 0.599 |
MST4 |
0.760 | 0.241 | 2 | 0.749 |
PRKD2 |
0.760 | 0.196 | -3 | 0.649 |
NDR1 |
0.759 | 0.256 | -3 | 0.728 |
PKG1 |
0.759 | 0.478 | -2 | 0.739 |
CLK4 |
0.759 | 0.388 | -3 | 0.659 |
NDR2 |
0.758 | 0.163 | -3 | 0.738 |
WNK1 |
0.758 | 0.263 | -2 | 0.478 |
AKT1 |
0.758 | 0.417 | -3 | 0.598 |
SGK3 |
0.757 | 0.359 | -3 | 0.649 |
COT |
0.756 | 0.034 | 2 | 0.701 |
RSK4 |
0.755 | 0.301 | -3 | 0.621 |
CAMLCK |
0.755 | 0.509 | -2 | 0.598 |
PIM3 |
0.755 | 0.153 | -3 | 0.731 |
PRKD1 |
0.755 | 0.133 | -3 | 0.688 |
IKKB |
0.754 | 0.015 | -2 | 0.264 |
AKT2 |
0.754 | 0.326 | -3 | 0.571 |
P90RSK |
0.753 | 0.198 | -3 | 0.640 |
PKN2 |
0.753 | 0.230 | -3 | 0.739 |
CDC7 |
0.752 | 0.067 | 1 | 0.640 |
CAMK1B |
0.752 | 0.258 | -3 | 0.747 |
CLK3 |
0.752 | 0.199 | 1 | 0.567 |
RIPK3 |
0.752 | 0.188 | 3 | 0.648 |
RAF1 |
0.752 | 0.146 | 1 | 0.749 |
P70S6KB |
0.752 | 0.273 | -3 | 0.679 |
CLK1 |
0.751 | 0.291 | -3 | 0.631 |
CAMK4 |
0.750 | 0.306 | -3 | 0.724 |
CLK2 |
0.750 | 0.286 | -3 | 0.646 |
PKCD |
0.750 | 0.260 | 2 | 0.622 |
PIM1 |
0.749 | 0.170 | -3 | 0.683 |
TBK1 |
0.749 | 0.014 | 1 | 0.726 |
CAMK2D |
0.749 | 0.080 | -3 | 0.720 |
IKKE |
0.749 | 0.012 | 1 | 0.729 |
TSSK1 |
0.748 | 0.179 | -3 | 0.766 |
PDHK1 |
0.747 | 0.061 | 1 | 0.745 |
DAPK2 |
0.747 | 0.416 | -3 | 0.749 |
GCN2 |
0.747 | -0.034 | 2 | 0.674 |
AKT3 |
0.746 | 0.347 | -3 | 0.508 |
AMPKA1 |
0.746 | 0.142 | -3 | 0.751 |
BCKDK |
0.746 | 0.023 | -1 | 0.712 |
PDHK4 |
0.746 | 0.017 | 1 | 0.716 |
MTOR |
0.745 | 0.015 | 1 | 0.652 |
LATS2 |
0.745 | 0.084 | -5 | 0.760 |
MAPKAPK3 |
0.745 | 0.093 | -3 | 0.658 |
ATR |
0.744 | 0.102 | 1 | 0.692 |
MARK4 |
0.743 | 0.048 | 4 | 0.830 |
PKCG |
0.743 | 0.218 | 2 | 0.580 |
PKN3 |
0.743 | 0.120 | -3 | 0.697 |
TGFBR2 |
0.742 | -0.005 | -2 | 0.308 |
PRKD3 |
0.742 | 0.159 | -3 | 0.614 |
NUAK2 |
0.742 | 0.059 | -3 | 0.739 |
NIK |
0.742 | 0.243 | -3 | 0.778 |
GRK1 |
0.742 | 0.053 | -2 | 0.291 |
PKCA |
0.741 | 0.229 | 2 | 0.576 |
MOS |
0.741 | 0.025 | 1 | 0.648 |
AMPKA2 |
0.741 | 0.118 | -3 | 0.716 |
RIPK1 |
0.741 | 0.149 | 1 | 0.716 |
WNK3 |
0.741 | 0.121 | 1 | 0.720 |
HIPK4 |
0.740 | 0.057 | 1 | 0.578 |
MRCKB |
0.740 | 0.428 | -3 | 0.625 |
CAMK2G |
0.740 | -0.007 | 2 | 0.688 |
MAPKAPK2 |
0.740 | 0.052 | -3 | 0.620 |
ULK2 |
0.739 | -0.044 | 2 | 0.633 |
HUNK |
0.739 | 0.065 | 2 | 0.662 |
CHAK2 |
0.739 | 0.022 | -1 | 0.763 |
PKCZ |
0.739 | 0.226 | 2 | 0.619 |
DYRK3 |
0.739 | 0.301 | 1 | 0.541 |
CAMK2B |
0.739 | 0.049 | 2 | 0.674 |
TSSK2 |
0.739 | 0.126 | -5 | 0.865 |
PRPK |
0.739 | -0.101 | -1 | 0.736 |
IKKA |
0.738 | -0.031 | -2 | 0.218 |
QSK |
0.738 | 0.084 | 4 | 0.814 |
DSTYK |
0.738 | -0.076 | 2 | 0.728 |
GRK5 |
0.738 | 0.013 | -3 | 0.807 |
PKCH |
0.737 | 0.219 | 2 | 0.566 |
ICK |
0.737 | 0.125 | -3 | 0.706 |
NLK |
0.737 | 0.046 | 1 | 0.630 |
NIM1 |
0.736 | 0.039 | 3 | 0.655 |
DAPK3 |
0.736 | 0.448 | -3 | 0.698 |
PKCT |
0.736 | 0.273 | 2 | 0.574 |
SIK |
0.736 | 0.057 | -3 | 0.653 |
PKCI |
0.736 | 0.300 | 2 | 0.589 |
SRPK1 |
0.735 | 0.055 | -3 | 0.623 |
SMMLCK |
0.735 | 0.406 | -3 | 0.690 |
PKCB |
0.735 | 0.133 | 2 | 0.576 |
NEK6 |
0.735 | -0.012 | -2 | 0.317 |
SGK1 |
0.735 | 0.276 | -3 | 0.493 |
CK1G1 |
0.735 | 0.114 | -3 | 0.659 |
MELK |
0.734 | 0.100 | -3 | 0.694 |
CAMK2A |
0.734 | 0.064 | 2 | 0.684 |
DAPK1 |
0.734 | 0.436 | -3 | 0.675 |
PHKG1 |
0.734 | 0.070 | -3 | 0.728 |
PIM2 |
0.734 | 0.190 | -3 | 0.624 |
MRCKA |
0.734 | 0.395 | -3 | 0.648 |
QIK |
0.734 | 0.058 | -3 | 0.727 |
BMPR2 |
0.734 | -0.089 | -2 | 0.331 |
NEK7 |
0.733 | -0.065 | -3 | 0.732 |
MASTL |
0.732 | -0.065 | -2 | 0.324 |
DNAPK |
0.732 | 0.063 | 1 | 0.694 |
MLK1 |
0.732 | -0.035 | 2 | 0.664 |
GRK6 |
0.732 | 0.023 | 1 | 0.679 |
DYRK2 |
0.731 | 0.075 | 1 | 0.504 |
NEK2 |
0.731 | 0.141 | 2 | 0.667 |
P70S6K |
0.731 | 0.187 | -3 | 0.574 |
HIPK2 |
0.731 | 0.097 | 1 | 0.417 |
HIPK1 |
0.731 | 0.141 | 1 | 0.522 |
GRK4 |
0.731 | -0.049 | -2 | 0.295 |
CAMK1G |
0.731 | 0.148 | -3 | 0.638 |
ROCK2 |
0.730 | 0.412 | -3 | 0.686 |
CK1A2 |
0.730 | 0.152 | -3 | 0.624 |
CK1E |
0.730 | 0.095 | -3 | 0.662 |
DMPK1 |
0.730 | 0.456 | -3 | 0.663 |
MARK3 |
0.729 | 0.046 | 4 | 0.779 |
ANKRD3 |
0.729 | 0.015 | 1 | 0.761 |
CDKL1 |
0.729 | -0.004 | -3 | 0.664 |
PHKG2 |
0.729 | 0.140 | -3 | 0.701 |
PKCE |
0.729 | 0.263 | 2 | 0.572 |
NEK9 |
0.729 | -0.042 | 2 | 0.693 |
NUAK1 |
0.728 | 0.007 | -3 | 0.676 |
KIS |
0.728 | -0.042 | 1 | 0.477 |
ULK1 |
0.728 | -0.095 | -3 | 0.703 |
TTBK2 |
0.727 | -0.046 | 2 | 0.568 |
ERK5 |
0.727 | -0.056 | 1 | 0.571 |
WNK4 |
0.727 | 0.167 | -2 | 0.444 |
CDKL5 |
0.727 | -0.008 | -3 | 0.652 |
SNRK |
0.727 | 0.079 | 2 | 0.552 |
CAMK1D |
0.726 | 0.177 | -3 | 0.572 |
BRSK2 |
0.726 | 0.021 | -3 | 0.707 |
DLK |
0.726 | -0.023 | 1 | 0.707 |
ATM |
0.725 | -0.002 | 1 | 0.668 |
MLK2 |
0.725 | -0.054 | 2 | 0.672 |
FAM20C |
0.725 | -0.012 | 2 | 0.512 |
SRPK2 |
0.725 | 0.033 | -3 | 0.543 |
DCAMKL1 |
0.725 | 0.111 | -3 | 0.687 |
MARK2 |
0.725 | 0.025 | 4 | 0.753 |
ROCK1 |
0.725 | 0.425 | -3 | 0.647 |
BRSK1 |
0.725 | 0.029 | -3 | 0.675 |
IRE1 |
0.724 | 0.016 | 1 | 0.663 |
LATS1 |
0.724 | 0.099 | -3 | 0.751 |
SSTK |
0.724 | 0.132 | 4 | 0.796 |
PKR |
0.724 | 0.132 | 1 | 0.699 |
TLK2 |
0.724 | -0.002 | 1 | 0.700 |
BMPR1B |
0.723 | -0.016 | 1 | 0.605 |
CDK7 |
0.723 | -0.005 | 1 | 0.456 |
PLK4 |
0.723 | -0.005 | 2 | 0.511 |
CDK8 |
0.723 | -0.044 | 1 | 0.474 |
CK1D |
0.723 | 0.097 | -3 | 0.630 |
MAPKAPK5 |
0.722 | 0.005 | -3 | 0.576 |
CAMK1A |
0.722 | 0.205 | -3 | 0.538 |
CHK1 |
0.722 | 0.033 | -3 | 0.713 |
HIPK3 |
0.722 | 0.120 | 1 | 0.534 |
YSK4 |
0.722 | -0.043 | 1 | 0.710 |
MST3 |
0.721 | 0.131 | 2 | 0.700 |
MARK1 |
0.721 | 0.019 | 4 | 0.793 |
TGFBR1 |
0.721 | -0.051 | -2 | 0.269 |
CHAK1 |
0.721 | 0.003 | 2 | 0.647 |
CDK19 |
0.721 | -0.038 | 1 | 0.446 |
SMG1 |
0.720 | -0.016 | 1 | 0.668 |
PKN1 |
0.720 | 0.148 | -3 | 0.602 |
SRPK3 |
0.720 | 0.013 | -3 | 0.590 |
ALK4 |
0.719 | -0.057 | -2 | 0.293 |
VRK2 |
0.719 | 0.062 | 1 | 0.721 |
MEK1 |
0.718 | -0.011 | 2 | 0.690 |
DYRK4 |
0.718 | 0.070 | 1 | 0.424 |
PLK1 |
0.718 | -0.075 | -2 | 0.285 |
CDK13 |
0.718 | -0.010 | 1 | 0.434 |
CDK12 |
0.717 | 0.021 | 1 | 0.414 |
ACVR2A |
0.716 | -0.059 | -2 | 0.265 |
DCAMKL2 |
0.716 | 0.067 | -3 | 0.706 |
DYRK1B |
0.716 | 0.086 | 1 | 0.446 |
CDK10 |
0.716 | 0.085 | 1 | 0.432 |
IRE2 |
0.715 | -0.014 | 2 | 0.588 |
CRIK |
0.715 | 0.260 | -3 | 0.584 |
MPSK1 |
0.714 | 0.083 | 1 | 0.661 |
ACVR2B |
0.714 | -0.066 | -2 | 0.257 |
CHK2 |
0.714 | 0.118 | -3 | 0.524 |
IRAK4 |
0.714 | 0.056 | 1 | 0.708 |
CDK18 |
0.714 | -0.013 | 1 | 0.389 |
GRK2 |
0.714 | -0.050 | -2 | 0.256 |
MLK3 |
0.714 | -0.064 | 2 | 0.594 |
DYRK1A |
0.713 | 0.053 | 1 | 0.514 |
PERK |
0.713 | -0.030 | -2 | 0.288 |
MLK4 |
0.713 | -0.066 | 2 | 0.569 |
DRAK1 |
0.713 | 0.017 | 1 | 0.619 |
TLK1 |
0.713 | -0.047 | -2 | 0.279 |
ALK2 |
0.713 | -0.057 | -2 | 0.278 |
GRK7 |
0.712 | -0.034 | 1 | 0.594 |
CDK14 |
0.712 | 0.065 | 1 | 0.448 |
CDK9 |
0.712 | -0.012 | 1 | 0.452 |
MEKK1 |
0.712 | -0.003 | 1 | 0.743 |
PLK3 |
0.711 | -0.084 | 2 | 0.636 |
MEKK3 |
0.711 | -0.026 | 1 | 0.710 |
IRAK1 |
0.711 | -0.013 | -1 | 0.715 |
JNK2 |
0.711 | -0.016 | 1 | 0.419 |
HPK1 |
0.711 | 0.156 | 1 | 0.720 |
GAK |
0.710 | 0.161 | 1 | 0.716 |
ZAK |
0.710 | -0.041 | 1 | 0.729 |
MEK5 |
0.710 | 0.016 | 2 | 0.676 |
MAK |
0.710 | 0.094 | -2 | 0.437 |
TAO3 |
0.710 | 0.043 | 1 | 0.683 |
P38A |
0.709 | -0.026 | 1 | 0.484 |
GRK3 |
0.709 | -0.028 | -2 | 0.245 |
BMPR1A |
0.709 | -0.028 | 1 | 0.599 |
NEK5 |
0.709 | 0.013 | 1 | 0.729 |
LOK |
0.708 | 0.152 | -2 | 0.393 |
CDK5 |
0.708 | -0.028 | 1 | 0.468 |
TTBK1 |
0.707 | -0.055 | 2 | 0.493 |
HRI |
0.707 | -0.088 | -2 | 0.309 |
CDK1 |
0.707 | -0.040 | 1 | 0.398 |
BRAF |
0.706 | -0.033 | -4 | 0.795 |
BUB1 |
0.706 | 0.180 | -5 | 0.813 |
ERK1 |
0.706 | -0.036 | 1 | 0.419 |
MEKK2 |
0.705 | -0.035 | 2 | 0.652 |
GCK |
0.705 | 0.078 | 1 | 0.717 |
PDK1 |
0.705 | 0.081 | 1 | 0.700 |
PRP4 |
0.705 | -0.016 | -3 | 0.677 |
KHS2 |
0.704 | 0.147 | 1 | 0.733 |
KHS1 |
0.704 | 0.139 | 1 | 0.736 |
HASPIN |
0.704 | 0.233 | -1 | 0.854 |
NEK4 |
0.704 | 0.058 | 1 | 0.734 |
NEK11 |
0.703 | -0.004 | 1 | 0.716 |
CAMKK2 |
0.703 | 0.027 | -2 | 0.316 |
CDK17 |
0.703 | -0.038 | 1 | 0.337 |
JNK3 |
0.703 | -0.044 | 1 | 0.437 |
PASK |
0.703 | 0.012 | -3 | 0.744 |
MAP3K15 |
0.702 | 0.042 | 1 | 0.711 |
LKB1 |
0.702 | 0.083 | -3 | 0.727 |
MINK |
0.702 | 0.058 | 1 | 0.743 |
P38G |
0.702 | -0.032 | 1 | 0.338 |
MEKK6 |
0.701 | 0.078 | 1 | 0.704 |
P38B |
0.701 | -0.053 | 1 | 0.409 |
CAMKK1 |
0.701 | -0.043 | -2 | 0.290 |
GSK3B |
0.701 | 0.026 | 4 | 0.423 |
SBK |
0.700 | 0.075 | -3 | 0.453 |
HGK |
0.700 | 0.046 | 3 | 0.740 |
PINK1 |
0.700 | -0.065 | 1 | 0.625 |
TNIK |
0.700 | 0.089 | 3 | 0.733 |
SLK |
0.699 | 0.042 | -2 | 0.321 |
PBK |
0.699 | 0.140 | 1 | 0.676 |
NEK8 |
0.699 | 0.032 | 2 | 0.664 |
TAO2 |
0.699 | 0.009 | 2 | 0.689 |
STK33 |
0.699 | 0.016 | 2 | 0.494 |
TAK1 |
0.698 | 0.044 | 1 | 0.732 |
ERK2 |
0.698 | -0.049 | 1 | 0.441 |
YSK1 |
0.698 | 0.085 | 2 | 0.674 |
MST2 |
0.697 | -0.047 | 1 | 0.732 |
CDK2 |
0.697 | -0.074 | 1 | 0.481 |
NEK1 |
0.697 | 0.083 | 1 | 0.718 |
MOK |
0.696 | 0.062 | 1 | 0.525 |
RIPK2 |
0.695 | -0.015 | 1 | 0.702 |
P38D |
0.695 | -0.049 | 1 | 0.383 |
YANK3 |
0.695 | 0.054 | 2 | 0.318 |
CDK3 |
0.695 | -0.032 | 1 | 0.352 |
CK1A |
0.694 | 0.071 | -3 | 0.564 |
NEK3 |
0.694 | 0.057 | 1 | 0.709 |
GSK3A |
0.694 | 0.014 | 4 | 0.426 |
EEF2K |
0.692 | -0.028 | 3 | 0.715 |
CDK16 |
0.692 | -0.043 | 1 | 0.351 |
VRK1 |
0.692 | 0.014 | 2 | 0.669 |
LRRK2 |
0.691 | 0.005 | 2 | 0.698 |
PLK2 |
0.690 | -0.065 | -3 | 0.685 |
MST1 |
0.688 | -0.036 | 1 | 0.723 |
CK2A2 |
0.686 | -0.062 | 1 | 0.464 |
ERK7 |
0.686 | -0.037 | 2 | 0.416 |
MEK2 |
0.685 | -0.040 | 2 | 0.671 |
CDK6 |
0.684 | -0.031 | 1 | 0.439 |
MYO3B |
0.683 | 0.101 | 2 | 0.684 |
CDK4 |
0.683 | -0.015 | 1 | 0.399 |
BIKE |
0.682 | 0.100 | 1 | 0.663 |
JNK1 |
0.681 | -0.065 | 1 | 0.384 |
CK2A1 |
0.677 | -0.066 | 1 | 0.442 |
MYO3A |
0.677 | 0.026 | 1 | 0.708 |
OSR1 |
0.676 | -0.022 | 2 | 0.656 |
CK1G3 |
0.676 | 0.088 | -3 | 0.524 |
TAO1 |
0.676 | 0.004 | 1 | 0.676 |
ASK1 |
0.676 | -0.008 | 1 | 0.700 |
TTK |
0.675 | -0.042 | -2 | 0.316 |
PDHK3_TYR |
0.674 | 0.081 | 4 | 0.847 |
AAK1 |
0.672 | 0.121 | 1 | 0.583 |
PKMYT1_TYR |
0.669 | 0.055 | 3 | 0.730 |
TESK1_TYR |
0.668 | 0.071 | 3 | 0.751 |
LIMK2_TYR |
0.668 | 0.164 | -3 | 0.784 |
PDHK4_TYR |
0.667 | 0.041 | 2 | 0.742 |
MAP2K7_TYR |
0.666 | 0.042 | 2 | 0.720 |
MAP2K4_TYR |
0.666 | -0.010 | -1 | 0.757 |
BMPR2_TYR |
0.663 | -0.008 | -1 | 0.761 |
MAP2K6_TYR |
0.663 | -0.045 | -1 | 0.759 |
RET |
0.662 | 0.059 | 1 | 0.703 |
PDHK1_TYR |
0.661 | -0.077 | -1 | 0.754 |
STLK3 |
0.661 | -0.085 | 1 | 0.692 |
TYK2 |
0.660 | -0.024 | 1 | 0.722 |
PINK1_TYR |
0.659 | -0.010 | 1 | 0.658 |
MST1R |
0.658 | -0.010 | 3 | 0.679 |
ALPHAK3 |
0.658 | -0.089 | -1 | 0.655 |
YANK2 |
0.658 | -0.008 | 2 | 0.325 |
LIMK1_TYR |
0.656 | 0.007 | 2 | 0.703 |
JAK2 |
0.656 | -0.043 | 1 | 0.719 |
CK1G2 |
0.654 | 0.023 | -3 | 0.596 |
TNK1 |
0.654 | 0.135 | 3 | 0.659 |
EPHA6 |
0.654 | -0.021 | -1 | 0.735 |
DDR1 |
0.654 | 0.013 | 4 | 0.769 |
TNNI3K_TYR |
0.654 | 0.064 | 1 | 0.715 |
NEK10_TYR |
0.653 | 0.023 | 1 | 0.601 |
JAK3 |
0.652 | -0.053 | 1 | 0.679 |
EPHB4 |
0.652 | -0.069 | -1 | 0.711 |
JAK1 |
0.651 | -0.014 | 1 | 0.719 |
ROS1 |
0.650 | -0.077 | 3 | 0.658 |
TYRO3 |
0.650 | -0.095 | 3 | 0.675 |
TNK2 |
0.649 | -0.013 | 3 | 0.616 |
FGR |
0.649 | -0.094 | 1 | 0.693 |
PDGFRB |
0.647 | -0.062 | 3 | 0.674 |
CSF1R |
0.647 | -0.118 | 3 | 0.658 |
KDR |
0.646 | -0.013 | 3 | 0.621 |
YES1 |
0.645 | -0.081 | -1 | 0.701 |
ABL2 |
0.644 | -0.073 | -1 | 0.656 |
EPHB1 |
0.644 | -0.100 | 1 | 0.705 |
LCK |
0.644 | -0.064 | -1 | 0.686 |
EPHB3 |
0.644 | -0.090 | -1 | 0.689 |
TXK |
0.643 | -0.083 | 1 | 0.639 |
WEE1_TYR |
0.643 | -0.017 | -1 | 0.646 |
EPHA4 |
0.642 | -0.084 | 2 | 0.641 |
ITK |
0.642 | -0.111 | -1 | 0.674 |
INSRR |
0.642 | -0.119 | 3 | 0.629 |
KIT |
0.642 | -0.111 | 3 | 0.657 |
HCK |
0.642 | -0.117 | -1 | 0.684 |
EPHB2 |
0.642 | -0.103 | -1 | 0.687 |
ABL1 |
0.642 | -0.079 | -1 | 0.650 |
FGFR2 |
0.641 | -0.098 | 3 | 0.663 |
FER |
0.641 | -0.152 | 1 | 0.689 |
PDGFRA |
0.640 | -0.104 | 3 | 0.671 |
AXL |
0.640 | -0.083 | 3 | 0.643 |
FLT3 |
0.640 | -0.116 | 3 | 0.656 |
SRMS |
0.640 | -0.145 | 1 | 0.686 |
EPHA1 |
0.639 | -0.041 | 3 | 0.619 |
FGFR1 |
0.639 | -0.118 | 3 | 0.637 |
FLT1 |
0.639 | -0.055 | -1 | 0.706 |
MET |
0.639 | -0.096 | 3 | 0.641 |
DDR2 |
0.638 | 0.049 | 3 | 0.614 |
BMX |
0.638 | -0.079 | -1 | 0.585 |
BLK |
0.637 | -0.073 | -1 | 0.691 |
MERTK |
0.637 | -0.098 | 3 | 0.631 |
FYN |
0.636 | -0.069 | -1 | 0.670 |
PTK6 |
0.636 | -0.138 | -1 | 0.610 |
EPHA7 |
0.636 | -0.075 | 2 | 0.625 |
ERBB2 |
0.635 | -0.117 | 1 | 0.658 |
LTK |
0.634 | -0.081 | 3 | 0.621 |
NTRK1 |
0.634 | -0.134 | -1 | 0.678 |
FLT4 |
0.634 | -0.083 | 3 | 0.635 |
EPHA3 |
0.634 | -0.114 | 2 | 0.615 |
BTK |
0.633 | -0.161 | -1 | 0.632 |
TEK |
0.633 | -0.137 | 3 | 0.604 |
ALK |
0.633 | -0.107 | 3 | 0.599 |
TEC |
0.633 | -0.115 | -1 | 0.602 |
FGFR3 |
0.632 | -0.114 | 3 | 0.635 |
LYN |
0.631 | -0.121 | 3 | 0.600 |
INSR |
0.630 | -0.138 | 3 | 0.617 |
NTRK2 |
0.630 | -0.151 | 3 | 0.620 |
EPHA5 |
0.628 | -0.103 | 2 | 0.617 |
FRK |
0.628 | -0.145 | -1 | 0.679 |
SRC |
0.627 | -0.107 | -1 | 0.666 |
SYK |
0.625 | -0.062 | -1 | 0.648 |
EGFR |
0.625 | -0.106 | 1 | 0.580 |
NTRK3 |
0.624 | -0.148 | -1 | 0.627 |
PTK2 |
0.624 | -0.056 | -1 | 0.693 |
EPHA8 |
0.624 | -0.118 | -1 | 0.677 |
FGFR4 |
0.623 | -0.109 | -1 | 0.638 |
CSK |
0.623 | -0.132 | 2 | 0.637 |
PTK2B |
0.623 | -0.123 | -1 | 0.642 |
MATK |
0.622 | -0.105 | -1 | 0.597 |
EPHA2 |
0.618 | -0.103 | -1 | 0.648 |
ERBB4 |
0.616 | -0.097 | 1 | 0.578 |
IGF1R |
0.614 | -0.137 | 3 | 0.555 |
MUSK |
0.612 | -0.128 | 1 | 0.567 |
ZAP70 |
0.608 | -0.062 | -1 | 0.586 |
FES |
0.603 | -0.143 | -1 | 0.572 |