Motif 414 (n=167)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PPC1 | PRR33 | S409 | ochoa | Proline rich 33 | None |
| A6NCI8 | C2orf78 | S813 | ochoa | Uncharacterized protein C2orf78 | None |
| A8MZF0 | PRR33 | S261 | ochoa | Proline-rich protein 33 | None |
| C9JH25 | PRRT4 | S731 | ochoa | Proline-rich transmembrane protein 4 | None |
| E7EW31 | PROB1 | S426 | ochoa | Proline-rich basic protein 1 | None |
| O00257 | CBX4 | S467 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O14490 | DLGAP1 | S52 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O15211 | RGL2 | S617 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15240 | VGF | S65 | ochoa | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M.luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}. |
| O15392 | BIRC5 | S20 | psp | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:16291752, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:20929775, ECO:0000269|PubMed:21364656, ECO:0000269|PubMed:21536684, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735, ECO:0000269|PubMed:9859993}. |
| O15417 | TNRC18 | S263 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43149 | ZZEF1 | S1276 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
| O43157 | PLXNB1 | S1902 | ochoa | Plexin-B1 (Semaphorin receptor SEP) | Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). {ECO:0000250|UniProtKB:Q8CJH3, ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
| O43561 | LAT | S101 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O60237 | PPP1R12B | S618 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60353 | FZD6 | S629 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| O75400 | PRPF40A | S429 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O94776 | MTA2 | S548 | ochoa | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| O94804 | STK10 | S485 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94913 | PCF11 | S645 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95049 | TJP3 | S864 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95251 | KAT7 | S100 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| P01042 | KNG1 | S391 | psp | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}. |
| P14598 | NCF1 | S370 | psp | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P14923 | JUP | S665 | ochoa|psp | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P16471 | PRLR | S429 | ochoa | Prolactin receptor (PRL-R) | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}. |
| P17480 | UBTF | S23 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P19174 | PLCG1 | S1263 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P19429 | TNNI3 | S150 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P19971 | TYMP | S50 | ochoa | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}. |
| P20700 | LMNB1 | S28 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P24821 | TNC | S903 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P38159 | RBMX | S189 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P41250 | GARS1 | S35 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P41250 | GARS1 | S54 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P46937 | YAP1 | S163 | ochoa|psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P48200 | IREB2 | S177 | ochoa | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}. |
| P51787 | KCNQ1 | S92 | ochoa | Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| P52943 | CRIP2 | S114 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P57078 | RIPK4 | S370 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P78332 | RBM6 | S461 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P82970 | HMGN5 | S24 | ochoa | High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) | Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000250}. |
| Q01082 | SPTBN1 | S825 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q03164 | KMT2A | S610 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03252 | LMNB2 | S42 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q04206 | RELA | S269 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q04637 | EIF4G1 | S1124 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q09666 | AHNAK | S332 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12923 | PTPN13 | S345 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13066 | GAGE2B | S32 | ochoa | G antigen 2B/2C (GAGE-2B) (GAGE-2C) (Cancer/testis antigen 4.2) (CT4.2) (G antigen 2C) | Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. |
| Q13191 | CBLB | S846 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13308 | PTK7 | S795 | ochoa | Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}. |
| Q14151 | SAFB2 | S818 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14162 | SCARF1 | S589 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14244 | MAP7 | S268 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14432 | PDE3A | S438 | ochoa|psp | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14469 | HES1 | S37 | psp | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}. |
| Q14571 | ITPR2 | S1855 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| Q14669 | TRIP12 | S997 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14669 | TRIP12 | S1054 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14934 | NFATC4 | S334 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14980 | NUMA1 | S1887 | ochoa|psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15019 | SEPTIN2 | S31 | ochoa | Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) | Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269|PubMed:15774761, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18209106, ECO:0000269|PubMed:19145258, ECO:0000305|PubMed:25588830}. |
| Q15035 | TRAM2 | S346 | ochoa | Translocating chain-associated membrane protein 2 | Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293). {ECO:0000269|PubMed:14749390, ECO:0000269|PubMed:27499293}. |
| Q15061 | WDR43 | S85 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15149 | PLEC | S3993 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15345 | LRRC41 | S326 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Q15424 | SAFB | S794 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q2M3V2 | SOWAHA | S260 | ochoa | Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) | None |
| Q5HYK7 | SH3D19 | S65 | ochoa | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:14551139, ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. |
| Q5T0Z8 | C6orf132 | S313 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T447 | HECTD3 | S95 | psp | E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) | E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}. |
| Q5VST9 | OBSCN | S6868 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q68CZ2 | TNS3 | S1199 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6DT37 | CDC42BPG | S1475 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6IQ23 | PLEKHA7 | S430 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NT46 | GAGE2A | S32 | ochoa | G antigen 2A (GAGE-2A) | None |
| Q6P1M3 | LLGL2 | S961 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6PJT7 | ZC3H14 | S132 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6PJT7 | ZC3H14 | S390 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6QNY0 | BLOC1S3 | S89 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
| Q6R327 | RICTOR | S265 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6UB99 | ANKRD11 | S2374 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6YP21 | KYAT3 | S189 | ochoa | Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). {ECO:0000250|UniProtKB:Q71RI9}. |
| Q6ZNL6 | FGD5 | S1328 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q70E73 | RAPH1 | S979 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7Z418 | KCNK18 | S262 | psp | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:12754259, PubMed:15562060, PubMed:20871611, PubMed:22355750, PubMed:26919430, PubMed:30573346). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (PubMed:34702947). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity). {ECO:0000250|UniProtKB:Q6VV64, ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611, ECO:0000269|PubMed:22355750, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:34702947}. |
| Q7Z591 | AKNA | S1170 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z591 | AKNA | S1387 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5R6 | APBB1IP | S525 | ochoa | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
| Q7Z6B7 | SRGAP1 | S865 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86TI0 | TBC1D1 | S235 | ochoa|psp | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86V48 | LUZP1 | S878 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86WR7 | PROSER2 | S382 | ochoa | Proline and serine-rich protein 2 | None |
| Q86YR5 | GPSM1 | S413 | ochoa | G-protein-signaling modulator 1 (Activator of G-protein signaling 3) | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}. |
| Q8IVT2 | MISP | S348 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWX8 | CHERP | S705 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IZ41 | RASEF | S406 | ochoa | Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) | Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). {ECO:0000269|PubMed:17448446, ECO:0000269|PubMed:30814157}. |
| Q8IZC4 | RTKN2 | S571 | ochoa | Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1) | May play an important role in lymphopoiesis. {ECO:0000269|PubMed:15504364}. |
| Q8N3D4 | EHBP1L1 | S1275 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3F8 | MICALL1 | S324 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4C8 | MINK1 | S673 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N612 | FHIP1B | S859 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8N684 | CPSF7 | S194 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NCD3 | HJURP | S686 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NFT6 | DBF4B | S279 | ochoa | Protein DBF4 homolog B (Activator of S phase kinase-like protein 1) (ASK-like protein 1) (Chiffon homolog B) (Dbf4-related factor 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232, ECO:0000269|PubMed:17062569}. |
| Q8TB72 | PUM2 | S67 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8TBC3 | SHKBP1 | S628 | ochoa | SH3KBP1-binding protein 1 (SETA-binding protein 1) | Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}. |
| Q8TD16 | BICD2 | S582 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TDF6 | RASGRP4 | S515 | ochoa | RAS guanyl-releasing protein 4 | Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity). {ECO:0000250|UniProtKB:Q8BTM9, ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}. |
| Q8TDM6 | DLG5 | S1232 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEH3 | DENND1A | S536 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8TEW0 | PARD3 | S1196 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF72 | SHROOM3 | S927 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUA4 | GTF3C2 | S147 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUA4 | GTF3C2 | S597 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WV24 | PHLDA1 | S95 | psp | Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein) | Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. {ECO:0000269|PubMed:11369516, ECO:0000269|PubMed:12738777}. |
| Q8WVQ1 | CANT1 | S21 | ochoa | Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107) | Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15006348, PubMed:15248776, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). {ECO:0000269|PubMed:12234496, ECO:0000269|PubMed:15006348, ECO:0000269|PubMed:15248776, ECO:0000269|PubMed:16835225, ECO:0000269|PubMed:22539336}. |
| Q8WWH5 | TRUB1 | S211 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q92785 | DPF2 | S94 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q969F2 | NKD2 | S299 | ochoa | Protein naked cuticle homolog 2 (Naked-2) (hNkd2) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. |
| Q96CN9 | GCC1 | S88 | ochoa | GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) | Probably involved in maintaining Golgi structure. |
| Q96E39 | RBMXL1 | S189 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96FF9 | CDCA5 | S29 | ochoa | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96FF9 | CDCA5 | S33 | ochoa|psp | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96FL8 | SLC47A1 | S23 | ochoa | Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) | Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:24961373, ECO:0000305|PubMed:35307651}. |
| Q96FS4 | SIPA1 | S912 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96HS1 | PGAM5 | S253 | ochoa | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}. |
| Q96IF1 | AJUBA | S79 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96JB3 | HIC2 | S166 | ochoa | Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) | Transcriptional repressor. |
| Q96JQ0 | DCHS1 | S3035 | ochoa | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}. |
| Q96KQ7 | EHMT2 | S211 | ochoa|psp | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96PK6 | RBM14 | S582 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96SN7 | ORAI2 | S33 | ochoa | Protein orai-2 (CAP-binding protein complex-interacting protein 2) (Transmembrane protein 142B) | Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. {ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:17452328, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:32415068, ECO:0000269|PubMed:33941685}. |
| Q99501 | GAS2L1 | S657 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99661 | KIF2C | S153 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q9BQE5 | APOL2 | S250 | ochoa | Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) | May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. |
| Q9BSJ6 | PIMREG | S164 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BXL7 | CARD11 | S893 | psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BZL4 | PPP1R12C | S532 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0J8 | WDR33 | S1218 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
| Q9H211 | CDT1 | S73 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H4E7 | DEF6 | S580 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H987 | SYNPO2L | S615 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9H9J4 | USP42 | S1133 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9NRI5 | DISC1 | S274 | ochoa | Disrupted in schizophrenia 1 protein | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}. |
| Q9NRL2 | BAZ1A | S1339 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NVM1 | EVA1B | S71 | ochoa | Protein eva-1 homolog B (Protein FAM176B) | None |
| Q9NYF8 | BCLAF1 | S320 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZI5 | GRHL1 | S95 | ochoa | Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32) | Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). May play a role in regulating glucose homeostasis and insulin signaling. {ECO:0000250|UniProtKB:Q921D9, ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:18288204, ECO:0000269|PubMed:29309642, ECO:0000269|PubMed:35013237}.; FUNCTION: [Isoform 1]: Functions as a transcription activator. {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:29309642}.; FUNCTION: [Isoform 2]: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. {ECO:0000269|PubMed:12175488}. |
| Q9P107 | GMIP | S19 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P244 | LRFN1 | S705 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P2G1 | ANKIB1 | S744 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9UEU5 | GAGE2D; | S32 | ochoa | G antigen 2D (GAGE-2D) (Cancer/testis antigen 4.8) (CT4.8) (G antigen 8) (GAGE-8) | None |
| Q9UIG0 | BAZ1B | S1315 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJY1 | HSPB8 | S57 | ochoa|psp | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22) | Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. {ECO:0000250|UniProtKB:Q9JK92}. |
| Q9ULW0 | TPX2 | S125 | ochoa|psp | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9Y3S1 | WNK2 | S45 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4H2 | IRS2 | S1109 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4K1 | CRYBG1 | S72 | ochoa | Beta/gamma crystallin domain-containing protein 1 (Absent in melanoma 1 protein) | May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. |
| Q9Y5S2 | CDC42BPB | S868 | ochoa|psp | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9GZM8 | NDEL1 | S251 | GPS6|SIGNOR | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9NXH9 | TRMT1 | S514 | Sugiyama | tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA methyltransferase 1) (hTRM1) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) | Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718). {ECO:0000269|PubMed:10982862, ECO:0000269|PubMed:28784718, ECO:0000269|PubMed:37204604, ECO:0000269|PubMed:39786990}. |
| P07332 | FES | S485 | Sugiyama | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| O14827 | RASGRF2 | S737 | GPS6|EPSD | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| Q07352 | ZFP36L1 | S84 | Sugiyama | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}. |
| Q5TAX3 | TUT4 | S1383 | Sugiyama | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.001785 | 2.748 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.003252 | 2.488 |
| R-HSA-1299344 | TWIK-related spinal cord K+ channel (TRESK) | 0.022109 | 1.655 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.043733 | 1.359 |
| R-HSA-167021 | PLC-gamma1 signalling | 0.054365 | 1.265 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.054365 | 1.265 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 0.064880 | 1.188 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.064880 | 1.188 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.009546 | 2.020 |
| R-HSA-74713 | IRS activation | 0.075279 | 1.123 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.014147 | 1.849 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.085563 | 1.068 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.085563 | 1.068 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 0.085563 | 1.068 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.095733 | 1.019 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.095733 | 1.019 |
| R-HSA-112412 | SOS-mediated signalling | 0.105790 | 0.976 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.115737 | 0.937 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.115737 | 0.937 |
| R-HSA-429947 | Deadenylation of mRNA | 0.044957 | 1.347 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.154434 | 0.811 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.154434 | 0.811 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.163842 | 0.786 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.163842 | 0.786 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.059041 | 1.229 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.182347 | 0.739 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.182347 | 0.739 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.191446 | 0.718 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.191446 | 0.718 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.191446 | 0.718 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.191446 | 0.718 |
| R-HSA-72187 | mRNA 3'-end processing | 0.030387 | 1.517 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.200445 | 0.698 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.218144 | 0.661 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.218144 | 0.661 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.243965 | 0.613 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.243965 | 0.613 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.056116 | 1.251 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.260707 | 0.584 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.260707 | 0.584 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.089329 | 1.049 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.089329 | 1.049 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.308750 | 0.510 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.176764 | 0.753 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.123944 | 0.907 |
| R-HSA-390522 | Striated Muscle Contraction | 0.360889 | 0.443 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.388908 | 0.410 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.141644 | 0.849 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.300964 | 0.521 |
| R-HSA-354192 | Integrin signaling | 0.353688 | 0.451 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.272025 | 0.565 |
| R-HSA-198203 | PI3K/AKT activation | 0.135300 | 0.869 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.268938 | 0.570 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.173146 | 0.762 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.209344 | 0.679 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.308750 | 0.510 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.059654 | 1.224 |
| R-HSA-2424491 | DAP12 signaling | 0.062019 | 1.207 |
| R-HSA-202433 | Generation of second messenger molecules | 0.097776 | 1.010 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.293091 | 0.533 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.388908 | 0.410 |
| R-HSA-202424 | Downstream TCR signaling | 0.303516 | 0.518 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.072832 | 1.138 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.176178 | 0.754 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.331594 | 0.479 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.300964 | 0.521 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.025610 | 1.592 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.068943 | 1.162 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.217134 | 0.663 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.274709 | 0.561 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.014147 | 1.849 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.101265 | 0.995 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.128884 | 0.890 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.182347 | 0.739 |
| R-HSA-202403 | TCR signaling | 0.049046 | 1.309 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.065986 | 1.181 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.039655 | 1.402 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.054365 | 1.265 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.004836 | 2.316 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.021473 | 1.668 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.125573 | 0.901 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.135300 | 0.869 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.135300 | 0.869 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.154434 | 0.811 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.047661 | 1.322 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.163842 | 0.786 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.173146 | 0.762 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.191446 | 0.718 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.191446 | 0.718 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.200445 | 0.698 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.200445 | 0.698 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.218144 | 0.661 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.043020 | 1.366 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.226847 | 0.644 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.097776 | 1.010 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.285130 | 0.545 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.308750 | 0.510 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.382020 | 0.418 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.120341 | 0.920 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.382020 | 0.418 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.382020 | 0.418 |
| R-HSA-68877 | Mitotic Prometaphase | 0.090782 | 1.042 |
| R-HSA-74749 | Signal attenuation | 0.135300 | 0.869 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.243965 | 0.613 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.360889 | 0.443 |
| R-HSA-373755 | Semaphorin interactions | 0.188759 | 0.724 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.182347 | 0.739 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.191446 | 0.718 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.172793 | 0.762 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.059041 | 1.229 |
| R-HSA-2172127 | DAP12 interactions | 0.115549 | 0.937 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.285130 | 0.545 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.266462 | 0.574 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.032981 | 1.482 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.135300 | 0.869 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.144920 | 0.839 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.019050 | 1.720 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.182347 | 0.739 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.209344 | 0.679 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.226847 | 0.644 |
| R-HSA-420029 | Tight junction interactions | 0.293091 | 0.533 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.331594 | 0.479 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.402455 | 0.395 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.136020 | 0.866 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.225315 | 0.647 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.293091 | 0.533 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.293091 | 0.533 |
| R-HSA-5578775 | Ion homeostasis | 0.035721 | 1.447 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.056115 | 1.251 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.095733 | 1.019 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.149316 | 0.826 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.353688 | 0.451 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.051005 | 1.292 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.017127 | 1.766 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.085563 | 1.068 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.105790 | 0.976 |
| R-HSA-1462054 | Alpha-defensins | 0.115737 | 0.937 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.012819 | 1.892 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.148125 | 0.829 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.274709 | 0.561 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.402455 | 0.395 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.278831 | 0.555 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.133893 | 0.873 |
| R-HSA-2028269 | Signaling by Hippo | 0.218144 | 0.661 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.375055 | 0.426 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.014147 | 1.849 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.360889 | 0.443 |
| R-HSA-4086398 | Ca2+ pathway | 0.229414 | 0.639 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.019572 | 1.708 |
| R-HSA-5576891 | Cardiac conduction | 0.025507 | 1.593 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.382020 | 0.418 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.252383 | 0.598 |
| R-HSA-397014 | Muscle contraction | 0.120187 | 0.920 |
| R-HSA-8953854 | Metabolism of RNA | 0.251052 | 0.600 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.075279 | 1.123 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.085563 | 1.068 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.125573 | 0.901 |
| R-HSA-448706 | Interleukin-1 processing | 0.125573 | 0.901 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.182347 | 0.739 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.182347 | 0.739 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.176764 | 0.753 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.119076 | 0.924 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.353688 | 0.451 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.154574 | 0.811 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.296206 | 0.528 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.319894 | 0.495 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.356994 | 0.447 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.067035 | 1.174 |
| R-HSA-186763 | Downstream signal transduction | 0.339041 | 0.470 |
| R-HSA-68886 | M Phase | 0.296792 | 0.528 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.226847 | 0.644 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.353688 | 0.451 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.324064 | 0.489 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.080889 | 1.092 |
| R-HSA-1280218 | Adaptive Immune System | 0.142790 | 0.845 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.040091 | 1.397 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 0.135300 | 0.869 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.218144 | 0.661 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.218144 | 0.661 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.134061 | 0.873 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.260707 | 0.584 |
| R-HSA-2559583 | Cellular Senescence | 0.025248 | 1.598 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.191446 | 0.718 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.101265 | 0.995 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.285130 | 0.545 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.121501 | 0.915 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.302275 | 0.520 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.135300 | 0.869 |
| R-HSA-210990 | PECAM1 interactions | 0.144920 | 0.839 |
| R-HSA-392517 | Rap1 signalling | 0.235454 | 0.628 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.260707 | 0.584 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.160974 | 0.793 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.300964 | 0.521 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.308750 | 0.510 |
| R-HSA-4839726 | Chromatin organization | 0.082911 | 1.081 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.062019 | 1.207 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.226847 | 0.644 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.101265 | 0.995 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.072832 | 1.138 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.059963 | 1.222 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.252383 | 0.598 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.252383 | 0.598 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.324064 | 0.489 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.331594 | 0.479 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.375055 | 0.426 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.252461 | 0.598 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.015539 | 1.809 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.268938 | 0.570 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 0.316450 | 0.500 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.133893 | 0.873 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.368012 | 0.434 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.375055 | 0.426 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.065876 | 1.181 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.402455 | 0.395 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.324064 | 0.489 |
| R-HSA-194138 | Signaling by VEGF | 0.021246 | 1.673 |
| R-HSA-9675108 | Nervous system development | 0.361902 | 0.441 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.034752 | 1.459 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.209344 | 0.679 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.308750 | 0.510 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.130306 | 0.885 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.077739 | 1.109 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.119196 | 0.924 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.157014 | 0.804 |
| R-HSA-2586552 | Signaling by Leptin | 0.135300 | 0.869 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.039728 | 1.401 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.225315 | 0.647 |
| R-HSA-166520 | Signaling by NTRKs | 0.116807 | 0.933 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.125573 | 0.901 |
| R-HSA-73614 | Pyrimidine salvage | 0.316450 | 0.500 |
| R-HSA-1296071 | Potassium Channels | 0.336180 | 0.473 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.187282 | 0.728 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.138968 | 0.857 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.296206 | 0.528 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.331594 | 0.479 |
| R-HSA-418346 | Platelet homeostasis | 0.380310 | 0.420 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.176764 | 0.753 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.176764 | 0.753 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.176764 | 0.753 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.176764 | 0.753 |
| R-HSA-68882 | Mitotic Anaphase | 0.126551 | 0.898 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.015309 | 1.815 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.077632 | 1.110 |
| R-HSA-69275 | G2/M Transition | 0.081486 | 1.089 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.128165 | 0.892 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.360027 | 0.444 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.084088 | 1.075 |
| R-HSA-1640170 | Cell Cycle | 0.066634 | 1.176 |
| R-HSA-162582 | Signal Transduction | 0.011116 | 1.954 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.100485 | 0.998 |
| R-HSA-8853659 | RET signaling | 0.084189 | 1.075 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.226847 | 0.644 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.353688 | 0.451 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.225315 | 0.647 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.388908 | 0.410 |
| R-HSA-8875878 | MET promotes cell motility | 0.395719 | 0.403 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.167978 | 0.775 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.382020 | 0.418 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.119203 | 0.924 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.157069 | 0.804 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.126405 | 0.898 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.308750 | 0.510 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.220441 | 0.657 |
| R-HSA-373753 | Nephrin family interactions | 0.243965 | 0.613 |
| R-HSA-186712 | Regulation of beta-cell development | 0.172793 | 0.762 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.241739 | 0.617 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.360889 | 0.443 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.042312 | 1.374 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.062019 | 1.207 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.084189 | 1.075 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.353688 | 0.451 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.170699 | 0.768 |
| R-HSA-3000170 | Syndecan interactions | 0.277079 | 0.557 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.371995 | 0.429 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.346405 | 0.460 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.229414 | 0.639 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.235454 | 0.628 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.277079 | 0.557 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.068124 | 1.167 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.176764 | 0.753 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.233518 | 0.632 |
| R-HSA-201556 | Signaling by ALK | 0.402455 | 0.395 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.285130 | 0.545 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.285130 | 0.545 |
| R-HSA-5205647 | Mitophagy | 0.368012 | 0.434 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.302275 | 0.520 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.308750 | 0.510 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.140009 | 0.854 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.382020 | 0.418 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.293091 | 0.533 |
| R-HSA-622312 | Inflammasomes | 0.316450 | 0.500 |
| R-HSA-75153 | Apoptotic execution phase | 0.122872 | 0.911 |
| R-HSA-73887 | Death Receptor Signaling | 0.302275 | 0.520 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.382020 | 0.418 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.237626 | 0.624 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.353688 | 0.451 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.402455 | 0.395 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.196818 | 0.706 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.241739 | 0.617 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.291186 | 0.536 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.403868 | 0.394 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.409116 | 0.388 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.409116 | 0.388 |
| R-HSA-5260271 | Diseases of Immune System | 0.409116 | 0.388 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.409116 | 0.388 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.409116 | 0.388 |
| R-HSA-71240 | Tryptophan catabolism | 0.409116 | 0.388 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.409116 | 0.388 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.409116 | 0.388 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.417224 | 0.380 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.422218 | 0.374 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.422218 | 0.374 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.422218 | 0.374 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.423173 | 0.373 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.425963 | 0.371 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.428660 | 0.368 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.428660 | 0.368 |
| R-HSA-165159 | MTOR signalling | 0.428660 | 0.368 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.434602 | 0.362 |
| R-HSA-449147 | Signaling by Interleukins | 0.434839 | 0.362 |
| R-HSA-1461973 | Defensins | 0.435031 | 0.361 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.435031 | 0.361 |
| R-HSA-73621 | Pyrimidine catabolism | 0.435031 | 0.361 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.435031 | 0.361 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.437115 | 0.359 |
| R-HSA-373752 | Netrin-1 signaling | 0.441331 | 0.355 |
| R-HSA-68875 | Mitotic Prophase | 0.442154 | 0.354 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.443572 | 0.353 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.443572 | 0.353 |
| R-HSA-422475 | Axon guidance | 0.446956 | 0.350 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.447562 | 0.349 |
| R-HSA-774815 | Nucleosome assembly | 0.447562 | 0.349 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.447562 | 0.349 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.447562 | 0.349 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.447562 | 0.349 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.447562 | 0.349 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.453723 | 0.343 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.453723 | 0.343 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.453723 | 0.343 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.453723 | 0.343 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.453723 | 0.343 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.453723 | 0.343 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.453723 | 0.343 |
| R-HSA-72172 | mRNA Splicing | 0.458086 | 0.339 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.459816 | 0.337 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.459816 | 0.337 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.460621 | 0.337 |
| R-HSA-69206 | G1/S Transition | 0.464472 | 0.333 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.464472 | 0.333 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.464472 | 0.333 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.464472 | 0.333 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.465841 | 0.332 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.468141 | 0.330 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.469016 | 0.329 |
| R-HSA-168256 | Immune System | 0.469522 | 0.328 |
| R-HSA-9766229 | Degradation of CDH1 | 0.471799 | 0.326 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.472157 | 0.326 |
| R-HSA-199991 | Membrane Trafficking | 0.473635 | 0.325 |
| R-HSA-109704 | PI3K Cascade | 0.477691 | 0.321 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.477691 | 0.321 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.483518 | 0.316 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.483518 | 0.316 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.489281 | 0.310 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.489281 | 0.310 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.489281 | 0.310 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.489281 | 0.310 |
| R-HSA-9843745 | Adipogenesis | 0.489838 | 0.310 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.493401 | 0.307 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.494979 | 0.305 |
| R-HSA-1221632 | Meiotic synapsis | 0.494979 | 0.305 |
| R-HSA-72649 | Translation initiation complex formation | 0.500614 | 0.300 |
| R-HSA-8951664 | Neddylation | 0.506166 | 0.296 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.506187 | 0.296 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.506187 | 0.296 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.510977 | 0.292 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.511697 | 0.291 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.511697 | 0.291 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.511697 | 0.291 |
| R-HSA-177929 | Signaling by EGFR | 0.511697 | 0.291 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.511697 | 0.291 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.517147 | 0.286 |
| R-HSA-112399 | IRS-mediated signalling | 0.517147 | 0.286 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.517147 | 0.286 |
| R-HSA-1500931 | Cell-Cell communication | 0.519081 | 0.285 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.519890 | 0.284 |
| R-HSA-6807070 | PTEN Regulation | 0.521330 | 0.283 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.522536 | 0.282 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.527865 | 0.277 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.527865 | 0.277 |
| R-HSA-983189 | Kinesins | 0.533136 | 0.273 |
| R-HSA-379724 | tRNA Aminoacylation | 0.533136 | 0.273 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.533136 | 0.273 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.538347 | 0.269 |
| R-HSA-112043 | PLC beta mediated events | 0.538347 | 0.269 |
| R-HSA-8956321 | Nucleotide salvage | 0.538347 | 0.269 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.543501 | 0.265 |
| R-HSA-186797 | Signaling by PDGF | 0.543501 | 0.265 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.543501 | 0.265 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.543501 | 0.265 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.543501 | 0.265 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.548218 | 0.261 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.548597 | 0.261 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.553637 | 0.257 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.553637 | 0.257 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.553637 | 0.257 |
| R-HSA-69242 | S Phase | 0.554774 | 0.256 |
| R-HSA-74160 | Gene expression (Transcription) | 0.555899 | 0.255 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.558621 | 0.253 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.558621 | 0.253 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.558621 | 0.253 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.563550 | 0.249 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.563550 | 0.249 |
| R-HSA-112040 | G-protein mediated events | 0.568424 | 0.245 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.568424 | 0.245 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.570469 | 0.244 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.573244 | 0.242 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.573244 | 0.242 |
| R-HSA-1989781 | PPARA activates gene expression | 0.577190 | 0.239 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.582723 | 0.235 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.582723 | 0.235 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.583204 | 0.234 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.583442 | 0.234 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.587384 | 0.231 |
| R-HSA-3000178 | ECM proteoglycans | 0.587384 | 0.231 |
| R-HSA-9638482 | Metal ion assimilation from the host | 0.587384 | 0.231 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.596551 | 0.224 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.596551 | 0.224 |
| R-HSA-109581 | Apoptosis | 0.598776 | 0.223 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.601059 | 0.221 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.601059 | 0.221 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.601059 | 0.221 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.602540 | 0.220 |
| R-HSA-917937 | Iron uptake and transport | 0.605516 | 0.218 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.605516 | 0.218 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.614585 | 0.211 |
| R-HSA-4086400 | PCP/CE pathway | 0.618593 | 0.209 |
| R-HSA-216083 | Integrin cell surface interactions | 0.618593 | 0.209 |
| R-HSA-9659379 | Sensory processing of sound | 0.622855 | 0.206 |
| R-HSA-1266738 | Developmental Biology | 0.623666 | 0.205 |
| R-HSA-72306 | tRNA processing | 0.625305 | 0.204 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.627070 | 0.203 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.627070 | 0.203 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.627070 | 0.203 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.627070 | 0.203 |
| R-HSA-6806834 | Signaling by MET | 0.627070 | 0.203 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.633843 | 0.198 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.633843 | 0.198 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.633843 | 0.198 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.635360 | 0.197 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.636655 | 0.196 |
| R-HSA-112316 | Neuronal System | 0.640729 | 0.193 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.647453 | 0.189 |
| R-HSA-1500620 | Meiosis | 0.647453 | 0.189 |
| R-HSA-446728 | Cell junction organization | 0.649239 | 0.188 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.651395 | 0.186 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.655292 | 0.184 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.655292 | 0.184 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.655900 | 0.183 |
| R-HSA-9658195 | Leishmania infection | 0.655900 | 0.183 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.659147 | 0.181 |
| R-HSA-70268 | Pyruvate metabolism | 0.659147 | 0.181 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.662958 | 0.179 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.662958 | 0.179 |
| R-HSA-9663891 | Selective autophagy | 0.662958 | 0.179 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.670455 | 0.174 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.670455 | 0.174 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.677785 | 0.169 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.681390 | 0.167 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.684425 | 0.165 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.684954 | 0.164 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.688478 | 0.162 |
| R-HSA-1474290 | Collagen formation | 0.688478 | 0.162 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.691964 | 0.160 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.698818 | 0.156 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.698818 | 0.156 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.698818 | 0.156 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.702189 | 0.154 |
| R-HSA-190236 | Signaling by FGFR | 0.705521 | 0.151 |
| R-HSA-422356 | Regulation of insulin secretion | 0.705521 | 0.151 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.705521 | 0.151 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.705521 | 0.151 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.705521 | 0.151 |
| R-HSA-3214847 | HATs acetylate histones | 0.708817 | 0.149 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.711022 | 0.148 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.715299 | 0.146 |
| R-HSA-5357801 | Programmed Cell Death | 0.717944 | 0.144 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.718486 | 0.144 |
| R-HSA-1483255 | PI Metabolism | 0.718486 | 0.144 |
| R-HSA-111885 | Opioid Signalling | 0.724753 | 0.140 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.727835 | 0.138 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.727835 | 0.138 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.730882 | 0.136 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.733895 | 0.134 |
| R-HSA-69239 | Synthesis of DNA | 0.736875 | 0.133 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.736875 | 0.133 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.736875 | 0.133 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.739822 | 0.131 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.739822 | 0.131 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.739822 | 0.131 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.739822 | 0.131 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.739822 | 0.131 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.739822 | 0.131 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.742735 | 0.129 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.742735 | 0.129 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.745617 | 0.127 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.745617 | 0.127 |
| R-HSA-6803157 | Antimicrobial peptides | 0.748466 | 0.126 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.751283 | 0.124 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.751283 | 0.124 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.751283 | 0.124 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.754070 | 0.123 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.760912 | 0.119 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.762243 | 0.118 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.767541 | 0.115 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.767541 | 0.115 |
| R-HSA-373760 | L1CAM interactions | 0.767541 | 0.115 |
| R-HSA-372790 | Signaling by GPCR | 0.770082 | 0.113 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.770146 | 0.113 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.775269 | 0.111 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.775269 | 0.111 |
| R-HSA-73886 | Chromosome Maintenance | 0.780279 | 0.108 |
| R-HSA-3371556 | Cellular response to heat stress | 0.780279 | 0.108 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.780279 | 0.108 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.782742 | 0.106 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.782742 | 0.106 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.785178 | 0.105 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.785178 | 0.105 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.787586 | 0.104 |
| R-HSA-157118 | Signaling by NOTCH | 0.788871 | 0.103 |
| R-HSA-388396 | GPCR downstream signalling | 0.789579 | 0.103 |
| R-HSA-114608 | Platelet degranulation | 0.796954 | 0.099 |
| R-HSA-109582 | Hemostasis | 0.800049 | 0.097 |
| R-HSA-8956319 | Nucleotide catabolism | 0.801483 | 0.096 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.803709 | 0.095 |
| R-HSA-1474165 | Reproduction | 0.805911 | 0.094 |
| R-HSA-421270 | Cell-cell junction organization | 0.807693 | 0.093 |
| R-HSA-9909396 | Circadian clock | 0.810241 | 0.091 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.810759 | 0.091 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.812370 | 0.090 |
| R-HSA-5688426 | Deubiquitination | 0.814160 | 0.089 |
| R-HSA-163685 | Integration of energy metabolism | 0.820650 | 0.086 |
| R-HSA-2262752 | Cellular responses to stress | 0.826907 | 0.083 |
| R-HSA-416476 | G alpha (q) signalling events | 0.828010 | 0.082 |
| R-HSA-1632852 | Macroautophagy | 0.830491 | 0.081 |
| R-HSA-913531 | Interferon Signaling | 0.831753 | 0.080 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.833864 | 0.079 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.843373 | 0.074 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.845132 | 0.073 |
| R-HSA-9758941 | Gastrulation | 0.846872 | 0.072 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.848592 | 0.071 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.848592 | 0.071 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.848592 | 0.071 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.850292 | 0.070 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.851974 | 0.070 |
| R-HSA-69306 | DNA Replication | 0.853637 | 0.069 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.853637 | 0.069 |
| R-HSA-9612973 | Autophagy | 0.858515 | 0.066 |
| R-HSA-418594 | G alpha (i) signalling events | 0.859522 | 0.066 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.864769 | 0.063 |
| R-HSA-195721 | Signaling by WNT | 0.872347 | 0.059 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.880584 | 0.055 |
| R-HSA-418555 | G alpha (s) signalling events | 0.881928 | 0.055 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.884569 | 0.053 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.884569 | 0.053 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.887151 | 0.052 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.887151 | 0.052 |
| R-HSA-168249 | Innate Immune System | 0.896155 | 0.048 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.896920 | 0.047 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.900362 | 0.046 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.902593 | 0.045 |
| R-HSA-212436 | Generic Transcription Pathway | 0.903677 | 0.044 |
| R-HSA-983712 | Ion channel transport | 0.903690 | 0.044 |
| R-HSA-5617833 | Cilium Assembly | 0.904774 | 0.043 |
| R-HSA-6798695 | Neutrophil degranulation | 0.904829 | 0.043 |
| R-HSA-1474244 | Extracellular matrix organization | 0.905132 | 0.043 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.905847 | 0.043 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.911031 | 0.040 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.916879 | 0.038 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.917816 | 0.037 |
| R-HSA-6805567 | Keratinization | 0.921459 | 0.036 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.926625 | 0.033 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.927452 | 0.033 |
| R-HSA-418990 | Adherens junctions interactions | 0.931453 | 0.031 |
| R-HSA-72312 | rRNA processing | 0.941524 | 0.026 |
| R-HSA-15869 | Metabolism of nucleotides | 0.944121 | 0.025 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.944752 | 0.025 |
| R-HSA-72766 | Translation | 0.962420 | 0.017 |
| R-HSA-597592 | Post-translational protein modification | 0.968722 | 0.014 |
| R-HSA-1483257 | Phospholipid metabolism | 0.971447 | 0.013 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.978533 | 0.009 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.979256 | 0.009 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.983113 | 0.007 |
| R-HSA-73894 | DNA Repair | 0.986412 | 0.006 |
| R-HSA-9679506 | SARS-CoV Infections | 0.989092 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.990475 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.990902 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.991210 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.992256 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.993404 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.998950 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999203 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999317 | 0.000 |
| R-HSA-9824446 | Viral Infection Pathways | 0.999976 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999983 | 0.000 |
| R-HSA-1643685 | Disease | 0.999986 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999996 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.853 | 0.776 | -2 | 0.749 |
AURB |
0.848 | 0.807 | -2 | 0.754 |
AURA |
0.845 | 0.817 | -2 | 0.812 |
PKACB |
0.839 | 0.658 | -2 | 0.694 |
PKACA |
0.835 | 0.637 | -2 | 0.725 |
PKG2 |
0.835 | 0.654 | -2 | 0.639 |
PAK6 |
0.832 | 0.684 | -2 | 0.674 |
PKACG |
0.829 | 0.585 | -2 | 0.547 |
PAK4 |
0.827 | 0.717 | -2 | 0.751 |
PRKX |
0.827 | 0.542 | -3 | 0.704 |
MSK1 |
0.826 | 0.596 | -3 | 0.757 |
PAK5 |
0.825 | 0.712 | -2 | 0.707 |
PAK1 |
0.822 | 0.665 | -2 | 0.593 |
PAK3 |
0.820 | 0.675 | -2 | 0.565 |
RSK2 |
0.819 | 0.395 | -3 | 0.777 |
MNK2 |
0.818 | 0.600 | -2 | 0.557 |
PAK2 |
0.815 | 0.710 | -2 | 0.595 |
MYLK4 |
0.815 | 0.628 | -2 | 0.609 |
RSK3 |
0.814 | 0.391 | -3 | 0.767 |
PKG1 |
0.812 | 0.581 | -2 | 0.681 |
MSK2 |
0.812 | 0.480 | -3 | 0.743 |
SKMLCK |
0.810 | 0.550 | -2 | 0.448 |
RSK4 |
0.810 | 0.423 | -3 | 0.746 |
CAMLCK |
0.808 | 0.676 | -2 | 0.465 |
AKT1 |
0.808 | 0.522 | -3 | 0.726 |
NDR1 |
0.808 | 0.330 | -3 | 0.844 |
P70S6KB |
0.806 | 0.394 | -3 | 0.799 |
CLK4 |
0.805 | 0.473 | -3 | 0.761 |
SGK3 |
0.805 | 0.447 | -3 | 0.790 |
P90RSK |
0.805 | 0.298 | -3 | 0.773 |
MNK1 |
0.805 | 0.519 | -2 | 0.525 |
PIM3 |
0.804 | 0.226 | -3 | 0.834 |
NDR2 |
0.803 | 0.191 | -3 | 0.848 |
AKT2 |
0.803 | 0.415 | -3 | 0.694 |
PRKD2 |
0.803 | 0.219 | -3 | 0.797 |
AKT3 |
0.801 | 0.453 | -3 | 0.642 |
DAPK2 |
0.797 | 0.561 | -3 | 0.857 |
LATS2 |
0.797 | 0.129 | -5 | 0.821 |
CAMK1B |
0.796 | 0.332 | -3 | 0.846 |
CAMK4 |
0.796 | 0.396 | -3 | 0.827 |
PIM1 |
0.796 | 0.230 | -3 | 0.788 |
PRKD1 |
0.795 | 0.134 | -3 | 0.845 |
CLK1 |
0.794 | 0.348 | -3 | 0.746 |
CLK3 |
0.794 | 0.246 | 1 | 0.769 |
COT |
0.794 | -0.001 | 2 | 0.836 |
MAPKAPK3 |
0.793 | 0.140 | -3 | 0.806 |
DYRK3 |
0.792 | 0.407 | 1 | 0.684 |
WNK1 |
0.792 | 0.238 | -2 | 0.298 |
PIM2 |
0.792 | 0.294 | -3 | 0.752 |
PKCD |
0.791 | 0.301 | 2 | 0.736 |
CLK2 |
0.791 | 0.359 | -3 | 0.749 |
DAPK3 |
0.791 | 0.591 | -3 | 0.799 |
MRCKB |
0.791 | 0.528 | -3 | 0.748 |
PKN2 |
0.791 | 0.265 | -3 | 0.846 |
MRCKA |
0.791 | 0.522 | -3 | 0.768 |
SGK1 |
0.790 | 0.382 | -3 | 0.626 |
AMPKA1 |
0.789 | 0.181 | -3 | 0.866 |
P70S6K |
0.789 | 0.304 | -3 | 0.718 |
RIPK3 |
0.789 | 0.211 | 3 | 0.755 |
CAMK2D |
0.788 | 0.087 | -3 | 0.852 |
IKKB |
0.788 | -0.066 | -2 | 0.128 |
SMMLCK |
0.788 | 0.542 | -3 | 0.812 |
PRKD3 |
0.787 | 0.199 | -3 | 0.747 |
DAPK1 |
0.787 | 0.575 | -3 | 0.776 |
CDC7 |
0.787 | 0.028 | 1 | 0.846 |
MAPKAPK2 |
0.786 | 0.103 | -3 | 0.756 |
PKN3 |
0.786 | 0.177 | -3 | 0.827 |
AMPKA2 |
0.786 | 0.167 | -3 | 0.839 |
MST4 |
0.786 | 0.155 | 2 | 0.791 |
TSSK1 |
0.785 | 0.159 | -3 | 0.886 |
RAF1 |
0.785 | 0.062 | 1 | 0.863 |
ICK |
0.784 | 0.173 | -3 | 0.828 |
MELK |
0.784 | 0.158 | -3 | 0.827 |
WNK3 |
0.783 | 0.172 | 1 | 0.844 |
NLK |
0.783 | 0.085 | 1 | 0.804 |
TGFBR2 |
0.783 | -0.017 | -2 | 0.171 |
TSSK2 |
0.783 | 0.161 | -5 | 0.835 |
NIK |
0.782 | 0.264 | -3 | 0.869 |
CAMK2G |
0.782 | 0.023 | 2 | 0.834 |
HIPK4 |
0.782 | 0.075 | 1 | 0.749 |
ROCK2 |
0.781 | 0.502 | -3 | 0.807 |
MARK4 |
0.781 | 0.040 | 4 | 0.840 |
TBK1 |
0.781 | -0.051 | 1 | 0.788 |
DMPK1 |
0.780 | 0.560 | -3 | 0.767 |
CDKL1 |
0.780 | 0.062 | -3 | 0.790 |
PKCA |
0.780 | 0.255 | 2 | 0.664 |
LATS1 |
0.780 | 0.190 | -3 | 0.858 |
CDKL5 |
0.780 | 0.058 | -3 | 0.790 |
PRPK |
0.780 | -0.091 | -1 | 0.826 |
NIM1 |
0.779 | 0.072 | 3 | 0.790 |
ATR |
0.779 | 0.102 | 1 | 0.839 |
CAMK2B |
0.779 | 0.088 | 2 | 0.820 |
CAMK2A |
0.779 | 0.118 | 2 | 0.815 |
NUAK2 |
0.779 | 0.060 | -3 | 0.841 |
MOS |
0.779 | -0.004 | 1 | 0.867 |
PDHK4 |
0.779 | -0.063 | 1 | 0.868 |
IKKE |
0.778 | -0.061 | 1 | 0.784 |
DYRK2 |
0.778 | 0.131 | 1 | 0.656 |
GCN2 |
0.778 | -0.108 | 2 | 0.785 |
PKCG |
0.778 | 0.220 | 2 | 0.674 |
RIPK1 |
0.778 | 0.153 | 1 | 0.848 |
SRPK1 |
0.777 | 0.088 | -3 | 0.743 |
ULK2 |
0.777 | -0.086 | 2 | 0.763 |
PDHK1 |
0.777 | -0.041 | 1 | 0.865 |
MTOR |
0.777 | -0.049 | 1 | 0.810 |
CAMK1D |
0.777 | 0.259 | -3 | 0.704 |
ROCK1 |
0.777 | 0.532 | -3 | 0.771 |
PKCT |
0.777 | 0.326 | 2 | 0.675 |
QSK |
0.776 | 0.093 | 4 | 0.816 |
BCKDK |
0.776 | -0.027 | -1 | 0.808 |
GRK1 |
0.775 | 0.005 | -2 | 0.157 |
ERK5 |
0.775 | 0.002 | 1 | 0.801 |
HUNK |
0.775 | 0.036 | 2 | 0.784 |
PKCH |
0.775 | 0.249 | 2 | 0.666 |
PKCI |
0.774 | 0.330 | 2 | 0.685 |
QIK |
0.774 | 0.076 | -3 | 0.836 |
HIPK1 |
0.774 | 0.186 | 1 | 0.674 |
BMPR2 |
0.774 | -0.122 | -2 | 0.171 |
SRPK2 |
0.774 | 0.091 | -3 | 0.670 |
BRSK1 |
0.773 | 0.098 | -3 | 0.801 |
PKCZ |
0.773 | 0.225 | 2 | 0.721 |
CAMK1G |
0.773 | 0.207 | -3 | 0.759 |
SSTK |
0.772 | 0.176 | 4 | 0.800 |
CHAK2 |
0.772 | -0.028 | -1 | 0.839 |
GRK5 |
0.771 | -0.053 | -3 | 0.815 |
SNRK |
0.771 | 0.147 | 2 | 0.684 |
PKCB |
0.771 | 0.140 | 2 | 0.665 |
IKKA |
0.771 | -0.098 | -2 | 0.080 |
MASTL |
0.770 | -0.090 | -2 | 0.162 |
SIK |
0.770 | 0.068 | -3 | 0.764 |
CRIK |
0.770 | 0.372 | -3 | 0.725 |
DSTYK |
0.770 | -0.133 | 2 | 0.839 |
DYRK1B |
0.769 | 0.164 | 1 | 0.595 |
CAMK1A |
0.769 | 0.278 | -3 | 0.663 |
PHKG1 |
0.769 | 0.074 | -3 | 0.839 |
BRSK2 |
0.769 | 0.063 | -3 | 0.832 |
PKCE |
0.769 | 0.312 | 2 | 0.659 |
MAPKAPK5 |
0.769 | 0.051 | -3 | 0.738 |
DCAMKL1 |
0.768 | 0.134 | -3 | 0.804 |
HIPK3 |
0.768 | 0.180 | 1 | 0.687 |
DYRK1A |
0.767 | 0.127 | 1 | 0.692 |
GRK6 |
0.767 | 0.015 | 1 | 0.841 |
DYRK4 |
0.767 | 0.134 | 1 | 0.572 |
FAM20C |
0.767 | 0.051 | 2 | 0.680 |
HIPK2 |
0.767 | 0.122 | 1 | 0.559 |
NEK7 |
0.766 | -0.132 | -3 | 0.821 |
NUAK1 |
0.766 | 0.009 | -3 | 0.797 |
NEK6 |
0.766 | -0.089 | -2 | 0.148 |
ULK1 |
0.766 | -0.117 | -3 | 0.784 |
MARK3 |
0.766 | 0.036 | 4 | 0.779 |
NEK2 |
0.766 | 0.106 | 2 | 0.757 |
PHKG2 |
0.765 | 0.167 | -3 | 0.804 |
PLK1 |
0.765 | -0.043 | -2 | 0.148 |
MLK1 |
0.765 | -0.090 | 2 | 0.758 |
MARK2 |
0.764 | 0.029 | 4 | 0.756 |
CHK1 |
0.764 | 0.028 | -3 | 0.855 |
MLK2 |
0.764 | -0.082 | 2 | 0.775 |
NEK9 |
0.763 | -0.101 | 2 | 0.786 |
PKN1 |
0.763 | 0.208 | -3 | 0.742 |
SRPK3 |
0.763 | 0.053 | -3 | 0.703 |
TGFBR1 |
0.763 | -0.045 | -2 | 0.123 |
ATM |
0.763 | 0.019 | 1 | 0.780 |
ANKRD3 |
0.763 | -0.042 | 1 | 0.885 |
DNAPK |
0.763 | 0.063 | 1 | 0.744 |
MARK1 |
0.762 | 0.037 | 4 | 0.792 |
WNK4 |
0.762 | 0.138 | -2 | 0.254 |
ALK4 |
0.762 | -0.048 | -2 | 0.144 |
CDK7 |
0.761 | 0.007 | 1 | 0.617 |
MAK |
0.760 | 0.137 | -2 | 0.311 |
DLK |
0.760 | -0.092 | 1 | 0.856 |
GRK4 |
0.760 | -0.116 | -2 | 0.142 |
IRE2 |
0.760 | 0.053 | 2 | 0.728 |
IRE1 |
0.760 | 0.003 | 1 | 0.800 |
SMG1 |
0.760 | 0.016 | 1 | 0.793 |
PKR |
0.759 | 0.047 | 1 | 0.842 |
BMPR1B |
0.758 | -0.035 | 1 | 0.793 |
DCAMKL2 |
0.758 | 0.086 | -3 | 0.816 |
KIS |
0.757 | -0.058 | 1 | 0.649 |
CHK2 |
0.757 | 0.170 | -3 | 0.651 |
TTBK2 |
0.757 | -0.116 | 2 | 0.672 |
VRK2 |
0.757 | 0.019 | 1 | 0.877 |
MEK1 |
0.756 | -0.049 | 2 | 0.824 |
ALK2 |
0.755 | -0.045 | -2 | 0.133 |
DRAK1 |
0.755 | 0.078 | 1 | 0.791 |
PLK4 |
0.755 | -0.038 | 2 | 0.652 |
IRAK4 |
0.754 | 0.065 | 1 | 0.825 |
PLK3 |
0.754 | -0.054 | 2 | 0.776 |
ACVR2A |
0.753 | -0.074 | -2 | 0.131 |
MLK3 |
0.753 | -0.074 | 2 | 0.681 |
CHAK1 |
0.753 | -0.040 | 2 | 0.739 |
CDK14 |
0.753 | 0.099 | 1 | 0.588 |
CDK8 |
0.752 | -0.063 | 1 | 0.612 |
YSK4 |
0.752 | -0.118 | 1 | 0.814 |
BUB1 |
0.751 | 0.191 | -5 | 0.793 |
ACVR2B |
0.751 | -0.078 | -2 | 0.121 |
CDK10 |
0.751 | 0.110 | 1 | 0.572 |
SBK |
0.751 | 0.137 | -3 | 0.587 |
GRK7 |
0.750 | -0.034 | 1 | 0.759 |
CDK13 |
0.749 | -0.010 | 1 | 0.591 |
BRAF |
0.749 | -0.035 | -4 | 0.777 |
MST3 |
0.748 | 0.059 | 2 | 0.765 |
P38A |
0.748 | -0.022 | 1 | 0.664 |
CDK9 |
0.748 | -0.003 | 1 | 0.603 |
CDK19 |
0.748 | -0.060 | 1 | 0.570 |
JNK2 |
0.747 | -0.012 | 1 | 0.566 |
MOK |
0.747 | 0.121 | 1 | 0.704 |
GRK2 |
0.747 | -0.073 | -2 | 0.130 |
CDK12 |
0.747 | 0.020 | 1 | 0.565 |
IRAK1 |
0.747 | -0.026 | -1 | 0.794 |
CDK18 |
0.746 | -0.009 | 1 | 0.540 |
LOK |
0.746 | 0.136 | -2 | 0.260 |
MPSK1 |
0.746 | 0.021 | 1 | 0.768 |
MLK4 |
0.746 | -0.105 | 2 | 0.673 |
PERK |
0.746 | -0.118 | -2 | 0.136 |
MEK5 |
0.745 | -0.031 | 2 | 0.792 |
PRP4 |
0.745 | 0.016 | -3 | 0.800 |
PASK |
0.745 | 0.056 | -3 | 0.844 |
HRI |
0.745 | -0.105 | -2 | 0.155 |
TLK2 |
0.745 | -0.125 | 1 | 0.795 |
CAMKK2 |
0.744 | -0.006 | -2 | 0.184 |
LKB1 |
0.744 | 0.052 | -3 | 0.852 |
BMPR1A |
0.743 | -0.048 | 1 | 0.771 |
P38B |
0.743 | -0.031 | 1 | 0.591 |
CDK5 |
0.742 | -0.022 | 1 | 0.629 |
CAMKK1 |
0.742 | -0.076 | -2 | 0.154 |
ZAK |
0.742 | -0.094 | 1 | 0.839 |
JNK3 |
0.742 | -0.033 | 1 | 0.601 |
NEK5 |
0.742 | -0.052 | 1 | 0.852 |
MEKK1 |
0.742 | -0.085 | 1 | 0.847 |
PDK1 |
0.741 | 0.063 | 1 | 0.830 |
ERK2 |
0.740 | -0.034 | 1 | 0.626 |
MEKK3 |
0.740 | -0.116 | 1 | 0.834 |
ERK1 |
0.739 | -0.045 | 1 | 0.581 |
TLK1 |
0.738 | -0.132 | -2 | 0.127 |
GSK3B |
0.738 | 0.023 | 4 | 0.449 |
TAO3 |
0.737 | -0.038 | 1 | 0.818 |
TAO2 |
0.737 | 0.001 | 2 | 0.796 |
HPK1 |
0.737 | 0.089 | 1 | 0.807 |
TTBK1 |
0.737 | -0.079 | 2 | 0.599 |
PINK1 |
0.737 | -0.094 | 1 | 0.784 |
GAK |
0.737 | 0.040 | 1 | 0.840 |
MEKK6 |
0.736 | 0.051 | 1 | 0.843 |
CDK1 |
0.736 | -0.041 | 1 | 0.565 |
RIPK2 |
0.736 | 0.028 | 1 | 0.793 |
CDK2 |
0.736 | -0.049 | 1 | 0.654 |
NEK8 |
0.736 | 0.010 | 2 | 0.769 |
GRK3 |
0.736 | -0.072 | -2 | 0.125 |
MEKK2 |
0.735 | -0.117 | 2 | 0.768 |
NEK4 |
0.735 | -0.006 | 1 | 0.822 |
CDK17 |
0.735 | -0.029 | 1 | 0.481 |
PBK |
0.734 | 0.075 | 1 | 0.771 |
SLK |
0.734 | 0.005 | -2 | 0.198 |
TNIK |
0.733 | 0.047 | 3 | 0.848 |
HGK |
0.733 | 0.001 | 3 | 0.849 |
NEK1 |
0.733 | 0.060 | 1 | 0.837 |
P38G |
0.733 | -0.034 | 1 | 0.483 |
CK2A2 |
0.732 | 0.027 | 1 | 0.718 |
STK33 |
0.732 | -0.010 | 2 | 0.601 |
GCK |
0.731 | -0.001 | 1 | 0.814 |
NEK11 |
0.731 | -0.079 | 1 | 0.832 |
CK1E |
0.731 | -0.068 | -3 | 0.481 |
MINK |
0.730 | -0.025 | 1 | 0.823 |
CDK3 |
0.730 | -0.007 | 1 | 0.502 |
GSK3A |
0.730 | 0.012 | 4 | 0.458 |
KHS1 |
0.730 | 0.066 | 1 | 0.806 |
LRRK2 |
0.730 | -0.024 | 2 | 0.803 |
VRK1 |
0.729 | -0.000 | 2 | 0.815 |
TAK1 |
0.729 | -0.032 | 1 | 0.835 |
CDK4 |
0.729 | 0.020 | 1 | 0.545 |
ERK7 |
0.729 | -0.019 | 2 | 0.473 |
KHS2 |
0.729 | 0.079 | 1 | 0.810 |
MAP3K15 |
0.728 | -0.044 | 1 | 0.824 |
CK1A2 |
0.728 | -0.004 | -3 | 0.431 |
MEK2 |
0.728 | -0.041 | 2 | 0.795 |
P38D |
0.728 | -0.044 | 1 | 0.510 |
CDK16 |
0.727 | -0.028 | 1 | 0.498 |
YSK1 |
0.726 | 0.022 | 2 | 0.745 |
NEK3 |
0.725 | -0.022 | 1 | 0.816 |
CK1D |
0.723 | -0.062 | -3 | 0.430 |
EEF2K |
0.723 | -0.054 | 3 | 0.825 |
CDK6 |
0.723 | -0.013 | 1 | 0.572 |
MST2 |
0.723 | -0.135 | 1 | 0.828 |
CK2A1 |
0.723 | 0.018 | 1 | 0.701 |
CK1G1 |
0.721 | -0.079 | -3 | 0.454 |
HASPIN |
0.720 | 0.076 | -1 | 0.735 |
MST1 |
0.719 | -0.108 | 1 | 0.815 |
PLK2 |
0.718 | -0.076 | -3 | 0.714 |
MYO3B |
0.716 | 0.086 | 2 | 0.767 |
PDHK3_TYR |
0.716 | 0.109 | 4 | 0.878 |
BIKE |
0.716 | 0.040 | 1 | 0.718 |
JNK1 |
0.715 | -0.058 | 1 | 0.544 |
LIMK2_TYR |
0.715 | 0.218 | -3 | 0.899 |
TTK |
0.712 | -0.057 | -2 | 0.170 |
ASK1 |
0.711 | -0.036 | 1 | 0.814 |
TAO1 |
0.711 | -0.013 | 1 | 0.771 |
TESK1_TYR |
0.711 | 0.105 | 3 | 0.874 |
OSR1 |
0.709 | -0.080 | 2 | 0.754 |
MYO3A |
0.707 | -0.007 | 1 | 0.801 |
YANK3 |
0.707 | 0.010 | 2 | 0.397 |
EPHA6 |
0.706 | 0.096 | -1 | 0.853 |
MAP2K7_TYR |
0.706 | 0.067 | 2 | 0.843 |
DDR1 |
0.706 | 0.152 | 4 | 0.797 |
RET |
0.705 | 0.134 | 1 | 0.839 |
PKMYT1_TYR |
0.705 | 0.010 | 3 | 0.843 |
PDHK4_TYR |
0.703 | 0.011 | 2 | 0.865 |
PINK1_TYR |
0.703 | 0.054 | 1 | 0.848 |
MAP2K4_TYR |
0.703 | -0.061 | -1 | 0.842 |
AAK1 |
0.702 | 0.052 | 1 | 0.611 |
TNK1 |
0.700 | 0.160 | 3 | 0.783 |
EPHB4 |
0.699 | 0.030 | -1 | 0.860 |
TYRO3 |
0.699 | 0.019 | 3 | 0.800 |
LIMK1_TYR |
0.699 | 0.034 | 2 | 0.826 |
MAP2K6_TYR |
0.699 | -0.091 | -1 | 0.831 |
TNK2 |
0.699 | 0.064 | 3 | 0.755 |
BMPR2_TYR |
0.698 | -0.036 | -1 | 0.827 |
MST1R |
0.698 | 0.031 | 3 | 0.802 |
DDR2 |
0.697 | 0.186 | 3 | 0.735 |
STLK3 |
0.695 | -0.120 | 1 | 0.790 |
PDHK1_TYR |
0.695 | -0.121 | -1 | 0.846 |
ROS1 |
0.695 | 0.001 | 3 | 0.776 |
TYK2 |
0.694 | -0.034 | 1 | 0.841 |
AXL |
0.694 | 0.050 | 3 | 0.776 |
JAK2 |
0.691 | -0.050 | 1 | 0.845 |
NEK10_TYR |
0.691 | 0.026 | 1 | 0.730 |
MERTK |
0.691 | 0.039 | 3 | 0.773 |
JAK3 |
0.691 | -0.018 | 1 | 0.834 |
PDGFRB |
0.690 | 0.005 | 3 | 0.797 |
YES1 |
0.690 | -0.017 | -1 | 0.857 |
ABL2 |
0.689 | -0.018 | -1 | 0.810 |
EPHB1 |
0.689 | -0.009 | 1 | 0.865 |
ALPHAK3 |
0.689 | -0.102 | -1 | 0.735 |
TXK |
0.689 | -0.019 | 1 | 0.850 |
EPHB3 |
0.688 | -0.009 | -1 | 0.854 |
FGFR2 |
0.688 | 0.001 | 3 | 0.796 |
CSF1R |
0.688 | -0.073 | 3 | 0.779 |
INSRR |
0.688 | -0.037 | 3 | 0.757 |
TNNI3K_TYR |
0.687 | 0.054 | 1 | 0.845 |
EPHA1 |
0.687 | 0.069 | 3 | 0.761 |
ITK |
0.687 | -0.047 | -1 | 0.833 |
SRMS |
0.686 | -0.069 | 1 | 0.857 |
KDR |
0.686 | 0.029 | 3 | 0.753 |
ABL1 |
0.685 | -0.035 | -1 | 0.812 |
EPHA4 |
0.685 | -0.038 | 2 | 0.772 |
FER |
0.685 | -0.080 | 1 | 0.867 |
LTK |
0.685 | 0.035 | 3 | 0.732 |
EPHB2 |
0.685 | -0.037 | -1 | 0.845 |
FGR |
0.684 | -0.103 | 1 | 0.862 |
TEK |
0.684 | -0.038 | 3 | 0.744 |
FGFR1 |
0.683 | -0.044 | 3 | 0.772 |
HCK |
0.683 | -0.082 | -1 | 0.840 |
LCK |
0.683 | -0.049 | -1 | 0.833 |
JAK1 |
0.683 | -0.018 | 1 | 0.807 |
EPHA7 |
0.682 | 0.004 | 2 | 0.766 |
PDGFRA |
0.682 | -0.050 | 3 | 0.792 |
FLT3 |
0.681 | -0.065 | 3 | 0.793 |
TEC |
0.681 | -0.018 | -1 | 0.804 |
CK1A |
0.681 | -0.091 | -3 | 0.334 |
ALK |
0.681 | -0.009 | 3 | 0.715 |
BMX |
0.681 | -0.027 | -1 | 0.752 |
BTK |
0.680 | -0.069 | -1 | 0.832 |
WEE1_TYR |
0.679 | 0.004 | -1 | 0.775 |
KIT |
0.679 | -0.097 | 3 | 0.780 |
BLK |
0.678 | -0.041 | -1 | 0.831 |
EPHA3 |
0.678 | -0.054 | 2 | 0.749 |
PTK2B |
0.676 | -0.019 | -1 | 0.820 |
NTRK1 |
0.676 | -0.087 | -1 | 0.812 |
FGFR3 |
0.675 | -0.054 | 3 | 0.772 |
PTK6 |
0.674 | -0.126 | -1 | 0.774 |
NTRK2 |
0.674 | -0.082 | 3 | 0.746 |
MET |
0.674 | -0.093 | 3 | 0.776 |
EPHA5 |
0.672 | -0.033 | 2 | 0.764 |
FLT4 |
0.672 | -0.056 | 3 | 0.748 |
FLT1 |
0.671 | -0.073 | -1 | 0.806 |
INSR |
0.671 | -0.087 | 3 | 0.738 |
FYN |
0.668 | -0.078 | -1 | 0.801 |
ERBB2 |
0.668 | -0.124 | 1 | 0.785 |
NTRK3 |
0.666 | -0.101 | -1 | 0.761 |
CK1G3 |
0.665 | -0.060 | -3 | 0.283 |
LYN |
0.665 | -0.114 | 3 | 0.715 |
FRK |
0.665 | -0.108 | -1 | 0.852 |
YANK2 |
0.664 | -0.075 | 2 | 0.416 |
EPHA8 |
0.663 | -0.080 | -1 | 0.816 |
MATK |
0.660 | -0.095 | -1 | 0.728 |
SRC |
0.659 | -0.106 | -1 | 0.812 |
CSK |
0.658 | -0.121 | 2 | 0.771 |
EGFR |
0.658 | -0.105 | 1 | 0.701 |
EPHA2 |
0.657 | -0.062 | -1 | 0.787 |
FGFR4 |
0.656 | -0.110 | -1 | 0.766 |
IGF1R |
0.656 | -0.085 | 3 | 0.681 |
PTK2 |
0.655 | -0.058 | -1 | 0.759 |
MUSK |
0.653 | -0.088 | 1 | 0.688 |
SYK |
0.646 | -0.117 | -1 | 0.731 |
ERBB4 |
0.643 | -0.108 | 1 | 0.697 |
FES |
0.643 | -0.103 | -1 | 0.738 |
CK1G2 |
0.641 | -0.110 | -3 | 0.375 |
ZAP70 |
0.624 | -0.113 | -1 | 0.646 |