Motif 411 (n=107)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | Y687 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A6NKT7 | RGPD3 | S1591 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| F8WAN1 | SPECC1L-ADORA2A | S385 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| O00534 | VWA5A | S105 | ochoa | von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) | May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. |
| O14654 | IRS4 | S918 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14715 | RGPD8 | S1590 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15085 | ARHGEF11 | S547 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O60716 | CTNND1 | S862 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60841 | EIF5B | S183 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O94875 | SORBS2 | S235 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95071 | UBR5 | S1733 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95183 | VAMP5 | S49 | ochoa | Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin) | May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. |
| O95684 | CEP43 | S205 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| P04350 | TUBB4A | Y340 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05023 | ATP1A1 | S369 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P07437 | TUBB | Y340 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08559 | PDHA1 | S293 | ochoa|psp | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}. |
| P09874 | PARP1 | S463 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0DJD0 | RGPD1 | S1575 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1583 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10275 | AR | S207 | ochoa | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P13637 | ATP1A3 | S359 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P21728 | DRD1 | S259 | psp | D(1A) dopamine receptor (Dopamine D1 receptor) | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| P27348 | YWHAQ | T215 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P28290 | ITPRID2 | S650 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29803 | PDHA2 | S291 | ochoa|psp | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:16436377}. |
| P31946 | YWHAB | T217 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | T217 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P34910 | EVI2B | S295 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P46100 | ATRX | S26 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49792 | RANBP2 | S2566 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50993 | ATP1A2 | S367 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P53004 | BLVRA | S235 | ochoa | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
| P53999 | SUB1 | S51 | ochoa | Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14) | General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). {ECO:0000269|PubMed:16605275, ECO:0000269|PubMed:16689930, ECO:0000269|PubMed:7628453, ECO:0000269|PubMed:8062391, ECO:0000269|PubMed:8062392, ECO:0000269|PubMed:9360603, ECO:0000269|PubMed:9482861}. |
| P54132 | BLM | S72 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55196 | AFDN | S1315 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P61978 | HNRNPK | S82 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P61981 | YWHAG | T220 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | T218 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | T215 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P68371 | TUBB4B | Y340 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q01105 | SET | S166 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q04917 | YWHAH | T220 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q08211 | DHX9 | S1033 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12830 | BPTF | S1374 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12929 | EPS8 | S481 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13009 | TIAM1 | S334 | psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13129 | RLF | S1237 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13509 | TUBB3 | Y340 | ochoa|psp | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13733 | ATP1A4 | S377 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. |
| Q13885 | TUBB2A | Y340 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q15596 | NCOA2 | S660 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16649 | NFIL3 | S353 | ochoa | Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}. |
| Q2LD37 | BLTP1 | S4539 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q49AR2 | C5orf22 | S176 | ochoa | UPF0489 protein C5orf22 | None |
| Q53QZ3 | ARHGAP15 | S343 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q5UIP0 | RIF1 | S1557 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT52 | RPRD2 | S817 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q69YN4 | VIRMA | S1603 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q69YQ0 | SPECC1L | S385 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6P0N0 | MIS18BP1 | S135 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6UXV4 | APOOL | S204 | ochoa | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979). {ECO:0000269|PubMed:23704930, ECO:0000269|PubMed:25764979}. |
| Q6VY07 | PACS1 | S411 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZW49 | PAXIP1 | S253 | ochoa | PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) | Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity). {ECO:0000250|UniProtKB:Q6NZQ4, ECO:0000269|PubMed:14576432, ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115, ECO:0000269|PubMed:17925232, ECO:0000269|PubMed:18353733, ECO:0000269|PubMed:20088963, ECO:0000269|PubMed:23727112}. |
| Q7L591 | DOK3 | S210 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7LDG7 | RASGRP2 | S117 | ochoa|psp | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| Q7Z3J3 | RGPD4 | S1591 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3U7 | MON2 | S649 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q86U06 | RBM23 | S36 | ochoa | Probable RNA-binding protein 23 (CAPER beta) (CAPERbeta) (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2) | RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). {ECO:0000269|PubMed:15694343}. |
| Q8IUD2 | ERC1 | S995 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IWC1 | MAP7D3 | S832 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8N108 | MIER1 | S122 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8N8S7 | ENAH | S486 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8TEW0 | PARD3 | S221 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TEY7 | USP33 | S387 | ochoa | Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}. |
| Q8WVJ2 | NUDCD2 | S137 | ochoa | NudC domain-containing protein 2 | May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. {ECO:0000269|PubMed:20133715}. |
| Q8WWM7 | ATXN2L | S273 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q92585 | MAML1 | S284 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q96B97 | SH3KBP1 | S189 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96K76 | USP47 | S897 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96MU7 | YTHDC1 | S318 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q99081 | TCF12 | S545 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99575 | POP1 | S24 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q99666 | RGPD5 | S1590 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BUF5 | TUBB6 | Y340 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | Y340 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BX66 | SORBS1 | S326 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BYW2 | SETD2 | S1207 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZF1 | OSBPL8 | S808 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9H3P7 | ACBD3 | S316 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9H4L7 | SMARCAD1 | S245 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9NVF7 | FBXO28 | S336 | ochoa | F-box only protein 28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}. |
| Q9NY27 | PPP4R2 | S216 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NZB2 | FAM120A | S511 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9UBF6 | RNF7 | S20 | ochoa | RING-box protein 2 (Rbx2) (EC 2.3.2.27) (EC 2.3.2.32) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) | Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733, PubMed:35512830). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:21980433, PubMed:33268465). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (PubMed:34518685). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (By similarity). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (PubMed:33268465). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (PubMed:34518685, PubMed:38418882). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (PubMed:19250909). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (PubMed:19250909). May play a role in protecting cells from apoptosis induced by redox agents (PubMed:10082581). {ECO:0000250|UniProtKB:Q9WTZ1, ECO:0000269|PubMed:10082581, ECO:0000269|PubMed:19250909, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:27910872, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:38418882, ECO:0000269|PubMed:38574733}.; FUNCTION: [Isoform 2]: Inactive. {ECO:0000269|PubMed:11506706}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, catalytic component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:23300442}. |
| Q9UJM3 | ERRFI1 | S391 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UJY4 | GGA2 | S327 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9UKX7 | NUP50 | S263 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULH0 | KIDINS220 | S1662 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9UQ35 | SRRM2 | S1219 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y253 | POLH | S551 | ochoa | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}. |
| Q9Y2X9 | ZNF281 | S800 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y4B4 | RAD54L2 | S674 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y6R1 | SLC4A4 | S233 | psp | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q9Y6X4 | FAM169A | S350 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| Q14247 | CTTN | S332 | Sugiyama | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| P35372 | OPRM1 | S358 | SIGNOR | Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) | Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.332268e-15 | 14.875 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 5.447776e-11 | 10.264 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.173021e-10 | 9.931 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.173021e-10 | 9.931 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.173021e-10 | 9.931 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.379931e-10 | 9.860 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.216770e-10 | 9.493 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 4.365492e-10 | 9.360 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 6.317511e-09 | 8.199 |
| R-HSA-114452 | Activation of BH3-only proteins | 9.316825e-09 | 8.031 |
| R-HSA-1640170 | Cell Cycle | 8.454535e-09 | 8.073 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.603388e-08 | 7.795 |
| R-HSA-190861 | Gap junction assembly | 2.249217e-08 | 7.648 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.234793e-08 | 7.490 |
| R-HSA-69275 | G2/M Transition | 3.010797e-08 | 7.521 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.343338e-08 | 7.476 |
| R-HSA-68877 | Mitotic Prometaphase | 4.323328e-08 | 7.364 |
| R-HSA-9646399 | Aggrephagy | 5.650742e-08 | 7.248 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 6.738629e-08 | 7.171 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 7.702402e-08 | 7.113 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 7.477434e-08 | 7.126 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.687601e-08 | 7.061 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 9.385860e-08 | 7.028 |
| R-HSA-190828 | Gap junction trafficking | 1.113893e-07 | 6.953 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.621064e-07 | 6.790 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.540565e-07 | 6.812 |
| R-HSA-437239 | Recycling pathway of L1 | 1.621064e-07 | 6.790 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.057532e-07 | 6.687 |
| R-HSA-9833482 | PKR-mediated signaling | 2.617042e-07 | 6.582 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.173367e-07 | 6.498 |
| R-HSA-5617833 | Cilium Assembly | 3.320553e-07 | 6.479 |
| R-HSA-9824446 | Viral Infection Pathways | 3.928209e-07 | 6.406 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.003991e-07 | 6.398 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.444783e-07 | 6.352 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.789960e-07 | 6.320 |
| R-HSA-983189 | Kinesins | 6.638657e-07 | 6.178 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.038377e-07 | 6.095 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.831234e-07 | 6.007 |
| R-HSA-68886 | M Phase | 1.127572e-06 | 5.948 |
| R-HSA-199991 | Membrane Trafficking | 1.181407e-06 | 5.928 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.779166e-06 | 5.750 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.757822e-06 | 5.559 |
| R-HSA-5620924 | Intraflagellar transport | 3.421013e-06 | 5.466 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.593849e-06 | 5.444 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.102135e-06 | 5.215 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.308970e-06 | 5.200 |
| R-HSA-9663891 | Selective autophagy | 6.744463e-06 | 5.171 |
| R-HSA-69481 | G2/M Checkpoints | 8.777850e-06 | 5.057 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.265005e-05 | 4.898 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.265005e-05 | 4.898 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.304052e-05 | 4.885 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.304052e-05 | 4.885 |
| R-HSA-9679506 | SARS-CoV Infections | 1.466837e-05 | 4.834 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.643176e-05 | 4.784 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.790101e-05 | 4.747 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.826399e-05 | 4.738 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.211121e-05 | 4.655 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.354731e-05 | 4.628 |
| R-HSA-9609646 | HCMV Infection | 2.447324e-05 | 4.611 |
| R-HSA-9609690 | HCMV Early Events | 2.477281e-05 | 4.606 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.715342e-05 | 4.566 |
| R-HSA-380287 | Centrosome maturation | 3.107558e-05 | 4.508 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 3.927577e-05 | 4.406 |
| R-HSA-373760 | L1CAM interactions | 4.327504e-05 | 4.364 |
| R-HSA-109581 | Apoptosis | 4.688994e-05 | 4.329 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.063047e-05 | 4.296 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.474577e-05 | 4.262 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.999418e-05 | 4.222 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.907693e-05 | 4.161 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.382502e-05 | 4.132 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.167338e-05 | 4.088 |
| R-HSA-391251 | Protein folding | 9.603641e-05 | 4.018 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.667241e-05 | 4.015 |
| R-HSA-5663205 | Infectious disease | 1.358751e-04 | 3.867 |
| R-HSA-1632852 | Macroautophagy | 1.442112e-04 | 3.841 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.515237e-04 | 3.820 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.731127e-04 | 3.762 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.876055e-04 | 3.727 |
| R-HSA-5357801 | Programmed Cell Death | 2.150923e-04 | 3.667 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.327025e-04 | 3.633 |
| R-HSA-68882 | Mitotic Anaphase | 2.955892e-04 | 3.529 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.039871e-04 | 3.517 |
| R-HSA-9612973 | Autophagy | 2.583212e-04 | 3.588 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.677178e-04 | 3.572 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.930337e-04 | 3.307 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.930337e-04 | 3.307 |
| R-HSA-913531 | Interferon Signaling | 6.271733e-04 | 3.203 |
| R-HSA-392517 | Rap1 signalling | 7.035112e-04 | 3.153 |
| R-HSA-422475 | Axon guidance | 7.068169e-04 | 3.151 |
| R-HSA-162582 | Signal Transduction | 8.556910e-04 | 3.068 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.745799e-04 | 3.058 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.974668e-04 | 3.001 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.050853e-03 | 2.978 |
| R-HSA-5578775 | Ion homeostasis | 1.175983e-03 | 2.930 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.178327e-03 | 2.929 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.178735e-03 | 2.929 |
| R-HSA-9675108 | Nervous system development | 1.215433e-03 | 2.915 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.301223e-03 | 2.886 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.317112e-03 | 2.880 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.385987e-03 | 2.858 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.804123e-03 | 2.744 |
| R-HSA-5693538 | Homology Directed Repair | 2.595514e-03 | 2.586 |
| R-HSA-170984 | ARMS-mediated activation | 3.383880e-03 | 2.471 |
| R-HSA-1266738 | Developmental Biology | 5.266229e-03 | 2.279 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 6.636821e-03 | 2.178 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 6.636821e-03 | 2.178 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.854905e-03 | 2.105 |
| R-HSA-1643685 | Disease | 7.939742e-03 | 2.100 |
| R-HSA-169893 | Prolonged ERK activation events | 9.060273e-03 | 2.043 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 9.943251e-03 | 2.002 |
| R-HSA-2028269 | Signaling by Hippo | 1.086288e-02 | 1.964 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.134045e-02 | 1.945 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.380834e-02 | 1.860 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.405995e-02 | 1.852 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.405995e-02 | 1.852 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.405995e-02 | 1.852 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.405995e-02 | 1.852 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.405995e-02 | 1.852 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.001350e-02 | 1.699 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.599159e-02 | 1.796 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.959712e-02 | 1.708 |
| R-HSA-73894 | DNA Repair | 1.882342e-02 | 1.725 |
| R-HSA-8953854 | Metabolism of RNA | 1.839550e-02 | 1.735 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.023899e-02 | 1.694 |
| R-HSA-5576891 | Cardiac conduction | 2.098963e-02 | 1.678 |
| R-HSA-1280218 | Adaptive Immune System | 1.880252e-02 | 1.726 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 2.101627e-02 | 1.677 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.195617e-02 | 1.658 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.291114e-02 | 1.640 |
| R-HSA-112316 | Neuronal System | 2.330251e-02 | 1.633 |
| R-HSA-397014 | Muscle contraction | 2.509705e-02 | 1.600 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.550293e-02 | 1.593 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 2.590966e-02 | 1.587 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.728700e-02 | 1.564 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.869330e-02 | 1.542 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.869330e-02 | 1.542 |
| R-HSA-166520 | Signaling by NTRKs | 3.086759e-02 | 1.510 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.159092e-02 | 1.500 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.159092e-02 | 1.500 |
| R-HSA-2262752 | Cellular responses to stress | 3.255897e-02 | 1.487 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.308131e-02 | 1.480 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.308131e-02 | 1.480 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.459882e-02 | 1.461 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.614299e-02 | 1.442 |
| R-HSA-187687 | Signalling to ERKs | 3.614299e-02 | 1.442 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.856854e-02 | 1.414 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.930955e-02 | 1.406 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 5.507478e-02 | 1.259 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.257750e-02 | 1.371 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.424842e-02 | 1.354 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.594341e-02 | 1.338 |
| R-HSA-8866376 | Reelin signalling pathway | 4.835837e-02 | 1.316 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.476500e-02 | 1.261 |
| R-HSA-205025 | NADE modulates death signalling | 4.159465e-02 | 1.381 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.032086e-02 | 1.220 |
| R-HSA-390651 | Dopamine receptors | 4.159465e-02 | 1.381 |
| R-HSA-444821 | Relaxin receptors | 5.507478e-02 | 1.259 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.424842e-02 | 1.354 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.424842e-02 | 1.354 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.594341e-02 | 1.338 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 5.507478e-02 | 1.259 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.093106e-02 | 1.388 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.659583e-02 | 1.247 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.659583e-02 | 1.247 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.257750e-02 | 1.371 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.681035e-02 | 1.330 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.383072e-02 | 1.358 |
| R-HSA-109582 | Hemostasis | 5.982934e-02 | 1.223 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.083587e-02 | 1.216 |
| R-HSA-983712 | Ion channel transport | 6.102666e-02 | 1.214 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.538040e-02 | 1.185 |
| R-HSA-74160 | Gene expression (Transcription) | 6.673355e-02 | 1.176 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 6.836694e-02 | 1.165 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 6.836694e-02 | 1.165 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.923923e-02 | 1.160 |
| R-HSA-68875 | Mitotic Prophase | 7.033358e-02 | 1.153 |
| R-HSA-73886 | Chromosome Maintenance | 7.156544e-02 | 1.145 |
| R-HSA-3371556 | Cellular response to heat stress | 7.156544e-02 | 1.145 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 7.494335e-02 | 1.125 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 7.494335e-02 | 1.125 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 7.494335e-02 | 1.125 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.531910e-02 | 1.123 |
| R-HSA-72172 | mRNA Splicing | 7.551482e-02 | 1.122 |
| R-HSA-193648 | NRAGE signals death through JNK | 7.601082e-02 | 1.119 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.805493e-02 | 1.108 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.805493e-02 | 1.108 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.147374e-02 | 1.089 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 8.147374e-02 | 1.089 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 8.147374e-02 | 1.089 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.147374e-02 | 1.089 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.176522e-02 | 1.087 |
| R-HSA-194441 | Metabolism of non-coding RNA | 8.219456e-02 | 1.085 |
| R-HSA-191859 | snRNP Assembly | 8.219456e-02 | 1.085 |
| R-HSA-597592 | Post-translational protein modification | 8.381056e-02 | 1.077 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 8.428940e-02 | 1.074 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 8.640048e-02 | 1.063 |
| R-HSA-9762292 | Regulation of CDH11 function | 8.795843e-02 | 1.056 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.071415e-01 | 0.970 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.259245e-01 | 0.900 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.563630e-01 | 0.806 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.563630e-01 | 0.806 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.623234e-01 | 0.790 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.623234e-01 | 0.790 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.623234e-01 | 0.790 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.623234e-01 | 0.790 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.339344e-01 | 0.873 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.682421e-01 | 0.774 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 9.439774e-02 | 1.025 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.128841e-01 | 0.947 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.071415e-01 | 0.970 |
| R-HSA-202040 | G-protein activation | 1.682421e-01 | 0.774 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 9.938980e-02 | 1.003 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.315527e-01 | 0.881 |
| R-HSA-192814 | vRNA Synthesis | 9.439774e-02 | 1.025 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.007920e-01 | 0.997 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.503606e-01 | 0.823 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.799553e-01 | 0.745 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.038350e-01 | 0.984 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.151777e-01 | 0.939 |
| R-HSA-170968 | Frs2-mediated activation | 1.134465e-01 | 0.945 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.259245e-01 | 0.900 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.623234e-01 | 0.790 |
| R-HSA-425381 | Bicarbonate transporters | 9.439774e-02 | 1.025 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.259245e-01 | 0.900 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.259245e-01 | 0.900 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.259245e-01 | 0.900 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.320980e-01 | 0.879 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.799553e-01 | 0.745 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.741193e-01 | 0.759 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.249939e-01 | 0.903 |
| R-HSA-9610379 | HCMV Late Events | 1.281261e-01 | 0.892 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.320980e-01 | 0.879 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.443158e-01 | 0.841 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.106027e-01 | 0.956 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.623234e-01 | 0.790 |
| R-HSA-70268 | Pyruvate metabolism | 1.484223e-01 | 0.829 |
| R-HSA-421270 | Cell-cell junction organization | 1.268858e-01 | 0.897 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.857505e-01 | 0.731 |
| R-HSA-157579 | Telomere Maintenance | 1.782512e-01 | 0.749 |
| R-HSA-446728 | Cell junction organization | 1.615968e-01 | 0.792 |
| R-HSA-168255 | Influenza Infection | 1.660177e-01 | 0.780 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.060779e-01 | 0.974 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.558243e-01 | 0.807 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.503606e-01 | 0.823 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.363260e-01 | 0.865 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.782512e-01 | 0.749 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.328768e-01 | 0.877 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.244690e-01 | 0.905 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.174833e-01 | 0.930 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.635398e-01 | 0.786 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.537014e-01 | 0.813 |
| R-HSA-72306 | tRNA processing | 1.508047e-01 | 0.822 |
| R-HSA-212436 | Generic Transcription Pathway | 1.447513e-01 | 0.839 |
| R-HSA-5619102 | SLC transporter disorders | 1.441964e-01 | 0.841 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.582512e-01 | 0.801 |
| R-HSA-73887 | Death Receptor Signaling | 1.234385e-01 | 0.909 |
| R-HSA-70171 | Glycolysis | 1.858511e-01 | 0.731 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 1.915051e-01 | 0.718 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.915051e-01 | 0.718 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.915051e-01 | 0.718 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.972193e-01 | 0.705 |
| R-HSA-420029 | Tight junction interactions | 1.972193e-01 | 0.705 |
| R-HSA-9839394 | TGFBR3 expression | 1.972193e-01 | 0.705 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.972193e-01 | 0.705 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 1.972193e-01 | 0.705 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.028935e-01 | 0.693 |
| R-HSA-525793 | Myogenesis | 2.028935e-01 | 0.693 |
| R-HSA-211000 | Gene Silencing by RNA | 2.063276e-01 | 0.685 |
| R-HSA-8949613 | Cristae formation | 2.085280e-01 | 0.681 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.085280e-01 | 0.681 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.085280e-01 | 0.681 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.085280e-01 | 0.681 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.085280e-01 | 0.681 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.141230e-01 | 0.669 |
| R-HSA-1500931 | Cell-Cell communication | 2.154563e-01 | 0.667 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.192484e-01 | 0.659 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.196787e-01 | 0.658 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.196787e-01 | 0.658 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.196787e-01 | 0.658 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.196787e-01 | 0.658 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.251956e-01 | 0.647 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.251956e-01 | 0.647 |
| R-HSA-182971 | EGFR downregulation | 2.306738e-01 | 0.637 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.361135e-01 | 0.627 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.361135e-01 | 0.627 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.361135e-01 | 0.627 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.374480e-01 | 0.624 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.374480e-01 | 0.624 |
| R-HSA-70326 | Glucose metabolism | 2.374480e-01 | 0.624 |
| R-HSA-418990 | Adherens junctions interactions | 2.381714e-01 | 0.623 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.415152e-01 | 0.617 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.415152e-01 | 0.617 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.415152e-01 | 0.617 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.415152e-01 | 0.617 |
| R-HSA-9930044 | Nuclear RNA decay | 2.415152e-01 | 0.617 |
| R-HSA-159418 | Recycling of bile acids and salts | 2.415152e-01 | 0.617 |
| R-HSA-354192 | Integrin signaling | 2.415152e-01 | 0.617 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.415152e-01 | 0.617 |
| R-HSA-168256 | Immune System | 2.453449e-01 | 0.610 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.468790e-01 | 0.608 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.468790e-01 | 0.608 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.468790e-01 | 0.608 |
| R-HSA-189483 | Heme degradation | 2.468790e-01 | 0.608 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.522052e-01 | 0.598 |
| R-HSA-5673000 | RAF activation | 2.522052e-01 | 0.598 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.522052e-01 | 0.598 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.522052e-01 | 0.598 |
| R-HSA-1980145 | Signaling by NOTCH2 | 2.522052e-01 | 0.598 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.522052e-01 | 0.598 |
| R-HSA-162906 | HIV Infection | 2.551377e-01 | 0.593 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.574940e-01 | 0.589 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.574940e-01 | 0.589 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.609576e-01 | 0.583 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.609576e-01 | 0.583 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.609576e-01 | 0.583 |
| R-HSA-3371511 | HSF1 activation | 2.627458e-01 | 0.580 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.627458e-01 | 0.580 |
| R-HSA-392499 | Metabolism of proteins | 2.675221e-01 | 0.573 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.679607e-01 | 0.572 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.679607e-01 | 0.572 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 2.679607e-01 | 0.572 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.731391e-01 | 0.564 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.731391e-01 | 0.564 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.782812e-01 | 0.556 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.833872e-01 | 0.548 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.833872e-01 | 0.548 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.833872e-01 | 0.548 |
| R-HSA-202433 | Generation of second messenger molecules | 2.833872e-01 | 0.548 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.884574e-01 | 0.540 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.884574e-01 | 0.540 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.884574e-01 | 0.540 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.884574e-01 | 0.540 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.884574e-01 | 0.540 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.884574e-01 | 0.540 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.933811e-01 | 0.533 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.934920e-01 | 0.532 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.934920e-01 | 0.532 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.934920e-01 | 0.532 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.934920e-01 | 0.532 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.934920e-01 | 0.532 |
| R-HSA-165159 | MTOR signalling | 2.984913e-01 | 0.525 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.984913e-01 | 0.525 |
| R-HSA-8854214 | TBC/RABGAPs | 3.034556e-01 | 0.518 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.083850e-01 | 0.511 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.083850e-01 | 0.511 |
| R-HSA-5688426 | Deubiquitination | 3.088075e-01 | 0.510 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.131673e-01 | 0.504 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.131673e-01 | 0.504 |
| R-HSA-774815 | Nucleosome assembly | 3.132798e-01 | 0.504 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.132798e-01 | 0.504 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.132798e-01 | 0.504 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.157638e-01 | 0.501 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.181404e-01 | 0.497 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.181404e-01 | 0.497 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.181404e-01 | 0.497 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.181404e-01 | 0.497 |
| R-HSA-9675135 | Diseases of DNA repair | 3.181404e-01 | 0.497 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.181404e-01 | 0.497 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.181404e-01 | 0.497 |
| R-HSA-75153 | Apoptotic execution phase | 3.181404e-01 | 0.497 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.229668e-01 | 0.491 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.277593e-01 | 0.484 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.325182e-01 | 0.478 |
| R-HSA-73893 | DNA Damage Bypass | 3.325182e-01 | 0.478 |
| R-HSA-9766229 | Degradation of CDH1 | 3.325182e-01 | 0.478 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.390265e-01 | 0.470 |
| R-HSA-912446 | Meiotic recombination | 3.419361e-01 | 0.466 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.441658e-01 | 0.463 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.455272e-01 | 0.462 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.465955e-01 | 0.460 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.512222e-01 | 0.454 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.512222e-01 | 0.454 |
| R-HSA-162587 | HIV Life Cycle | 3.518512e-01 | 0.454 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.603784e-01 | 0.443 |
| R-HSA-177929 | Signaling by EGFR | 3.649084e-01 | 0.438 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.649084e-01 | 0.438 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.649084e-01 | 0.438 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.694066e-01 | 0.432 |
| R-HSA-186712 | Regulation of beta-cell development | 3.783084e-01 | 0.422 |
| R-HSA-180786 | Extension of Telomeres | 3.783084e-01 | 0.422 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.827124e-01 | 0.417 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.827124e-01 | 0.417 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.827124e-01 | 0.417 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.827124e-01 | 0.417 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.827124e-01 | 0.417 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.827124e-01 | 0.417 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.870856e-01 | 0.412 |
| R-HSA-211976 | Endogenous sterols | 3.870856e-01 | 0.412 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.870856e-01 | 0.412 |
| R-HSA-418555 | G alpha (s) signalling events | 3.897826e-01 | 0.409 |
| R-HSA-9707616 | Heme signaling | 3.914280e-01 | 0.407 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.947697e-01 | 0.404 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.947697e-01 | 0.404 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.957399e-01 | 0.403 |
| R-HSA-373755 | Semaphorin interactions | 3.957399e-01 | 0.403 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.000216e-01 | 0.398 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.042732e-01 | 0.393 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.042732e-01 | 0.393 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 4.126869e-01 | 0.384 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.168495e-01 | 0.380 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.250872e-01 | 0.372 |
| R-HSA-375276 | Peptide ligand-binding receptors | 4.267210e-01 | 0.370 |
| R-HSA-189445 | Metabolism of porphyrins | 4.291627e-01 | 0.367 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.332095e-01 | 0.363 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.332095e-01 | 0.363 |
| R-HSA-6798695 | Neutrophil degranulation | 4.393955e-01 | 0.357 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.411751e-01 | 0.355 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.412181e-01 | 0.355 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.491145e-01 | 0.348 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.507013e-01 | 0.346 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.569002e-01 | 0.340 |
| R-HSA-9659379 | Sensory processing of sound | 4.607521e-01 | 0.337 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.607521e-01 | 0.337 |
| R-HSA-6806834 | Signaling by MET | 4.645769e-01 | 0.333 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.671519e-01 | 0.331 |
| R-HSA-977225 | Amyloid fiber formation | 4.683748e-01 | 0.329 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.683748e-01 | 0.329 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.796090e-01 | 0.319 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.796090e-01 | 0.319 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.833012e-01 | 0.316 |
| R-HSA-1500620 | Meiosis | 4.833012e-01 | 0.316 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.833012e-01 | 0.316 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.869674e-01 | 0.313 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.869674e-01 | 0.313 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.869674e-01 | 0.313 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.869674e-01 | 0.313 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.906079e-01 | 0.309 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.906079e-01 | 0.309 |
| R-HSA-388396 | GPCR downstream signalling | 4.955970e-01 | 0.305 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.978121e-01 | 0.303 |
| R-HSA-73884 | Base Excision Repair | 5.049153e-01 | 0.297 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.084295e-01 | 0.294 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.112607e-01 | 0.291 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.153839e-01 | 0.288 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.188244e-01 | 0.285 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.222407e-01 | 0.282 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.281612e-01 | 0.277 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.323460e-01 | 0.274 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.356671e-01 | 0.271 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.385094e-01 | 0.269 |
| R-HSA-3214847 | HATs acetylate histones | 5.422394e-01 | 0.266 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.422394e-01 | 0.266 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.454908e-01 | 0.263 |
| R-HSA-157118 | Signaling by NOTCH | 5.511477e-01 | 0.259 |
| R-HSA-111885 | Opioid Signalling | 5.582694e-01 | 0.253 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.582694e-01 | 0.253 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.614080e-01 | 0.251 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.614080e-01 | 0.251 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.645244e-01 | 0.248 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 5.655696e-01 | 0.248 |
| R-HSA-4839726 | Chromatin organization | 5.696509e-01 | 0.244 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.706917e-01 | 0.244 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.706917e-01 | 0.244 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.737428e-01 | 0.241 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 5.797806e-01 | 0.237 |
| R-HSA-202403 | TCR signaling | 5.797806e-01 | 0.237 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 5.886788e-01 | 0.230 |
| R-HSA-372790 | Signaling by GPCR | 5.936048e-01 | 0.227 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.973383e-01 | 0.224 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.002531e-01 | 0.222 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.030958e-01 | 0.220 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.030958e-01 | 0.220 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.069020e-01 | 0.217 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.115045e-01 | 0.214 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.224419e-01 | 0.206 |
| R-HSA-194138 | Signaling by VEGF | 6.304441e-01 | 0.200 |
| R-HSA-114608 | Platelet degranulation | 6.356853e-01 | 0.197 |
| R-HSA-1474165 | Reproduction | 6.459476e-01 | 0.190 |
| R-HSA-9843745 | Adipogenesis | 6.484681e-01 | 0.188 |
| R-HSA-9909396 | Circadian clock | 6.509708e-01 | 0.186 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.534558e-01 | 0.185 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.632218e-01 | 0.178 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.842091e-01 | 0.165 |
| R-HSA-9758941 | Gastrulation | 6.953030e-01 | 0.158 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.009462e-01 | 0.154 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.017730e-01 | 0.154 |
| R-HSA-1989781 | PPARA activates gene expression | 7.081068e-01 | 0.150 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.122550e-01 | 0.147 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.143072e-01 | 0.146 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.183681e-01 | 0.144 |
| R-HSA-382551 | Transport of small molecules | 7.194498e-01 | 0.143 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.274307e-01 | 0.138 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 7.321358e-01 | 0.135 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.434043e-01 | 0.129 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.628564e-01 | 0.118 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.900810e-01 | 0.102 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.908427e-01 | 0.102 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.945529e-01 | 0.100 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.945529e-01 | 0.100 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.986117e-01 | 0.098 |
| R-HSA-500792 | GPCR ligand binding | 8.104783e-01 | 0.091 |
| R-HSA-8951664 | Neddylation | 8.207615e-01 | 0.086 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.270890e-01 | 0.082 |
| R-HSA-449147 | Signaling by Interleukins | 8.401447e-01 | 0.076 |
| R-HSA-8939211 | ESR-mediated signaling | 8.402408e-01 | 0.076 |
| R-HSA-168249 | Innate Immune System | 8.508797e-01 | 0.070 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.537853e-01 | 0.069 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.606631e-01 | 0.065 |
| R-HSA-416476 | G alpha (q) signalling events | 8.684670e-01 | 0.061 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 8.810954e-01 | 0.055 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.844774e-01 | 0.053 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.901680e-01 | 0.051 |
| R-HSA-1483257 | Phospholipid metabolism | 8.948239e-01 | 0.048 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.955806e-01 | 0.048 |
| R-HSA-195721 | Signaling by WNT | 8.970779e-01 | 0.047 |
| R-HSA-8957322 | Metabolism of steroids | 9.147111e-01 | 0.039 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.277927e-01 | 0.033 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.447881e-01 | 0.025 |
| R-HSA-418594 | G alpha (i) signalling events | 9.536248e-01 | 0.021 |
| R-HSA-72766 | Translation | 9.604861e-01 | 0.018 |
| R-HSA-211859 | Biological oxidations | 9.801145e-01 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 9.998281e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999061e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.772 | 0.197 | 2 | 0.747 |
MOS |
0.757 | 0.212 | 1 | 0.751 |
CAMK2G |
0.756 | 0.100 | 2 | 0.680 |
IKKB |
0.755 | 0.092 | -2 | 0.658 |
GRK6 |
0.754 | 0.165 | 1 | 0.740 |
GRK1 |
0.754 | 0.201 | -2 | 0.693 |
CLK3 |
0.754 | 0.076 | 1 | 0.728 |
FAM20C |
0.753 | 0.080 | 2 | 0.544 |
GRK7 |
0.753 | 0.176 | 1 | 0.692 |
DSTYK |
0.751 | 0.064 | 2 | 0.747 |
MTOR |
0.749 | -0.011 | 1 | 0.728 |
PRPK |
0.749 | -0.035 | -1 | 0.378 |
PLK1 |
0.748 | 0.161 | -2 | 0.799 |
CK2A2 |
0.748 | 0.234 | 1 | 0.598 |
IKKA |
0.747 | 0.048 | -2 | 0.674 |
GRK4 |
0.746 | 0.046 | -2 | 0.780 |
RAF1 |
0.745 | -0.014 | 1 | 0.789 |
PIM3 |
0.745 | 0.018 | -3 | 0.804 |
TBK1 |
0.745 | -0.027 | 1 | 0.738 |
GRK5 |
0.744 | 0.011 | -3 | 0.834 |
BMPR1B |
0.744 | 0.123 | 1 | 0.694 |
ACVR2B |
0.744 | 0.179 | -2 | 0.800 |
ATR |
0.744 | 0.004 | 1 | 0.747 |
IKKE |
0.743 | -0.001 | 1 | 0.728 |
CDC7 |
0.743 | -0.054 | 1 | 0.736 |
BMPR2 |
0.742 | -0.032 | -2 | 0.810 |
PDHK4 |
0.742 | -0.123 | 1 | 0.779 |
PLK3 |
0.742 | 0.105 | 2 | 0.675 |
CAMK2B |
0.742 | 0.060 | 2 | 0.663 |
CK2A1 |
0.742 | 0.236 | 1 | 0.577 |
CAMK1B |
0.741 | -0.019 | -3 | 0.843 |
ACVR2A |
0.740 | 0.141 | -2 | 0.791 |
TGFBR1 |
0.740 | 0.087 | -2 | 0.741 |
ATM |
0.739 | 0.023 | 1 | 0.698 |
SKMLCK |
0.737 | -0.003 | -2 | 0.728 |
HUNK |
0.737 | -0.029 | 2 | 0.729 |
MLK1 |
0.737 | -0.026 | 2 | 0.674 |
RIPK3 |
0.736 | -0.017 | 3 | 0.598 |
NEK7 |
0.736 | -0.068 | -3 | 0.808 |
NEK6 |
0.736 | -0.046 | -2 | 0.847 |
DLK |
0.736 | 0.020 | 1 | 0.738 |
NDR2 |
0.735 | -0.052 | -3 | 0.819 |
ALK4 |
0.735 | 0.042 | -2 | 0.760 |
KIS |
0.735 | 0.046 | 1 | 0.607 |
GCN2 |
0.735 | -0.106 | 2 | 0.640 |
PKN3 |
0.735 | -0.021 | -3 | 0.801 |
WNK1 |
0.734 | -0.055 | -2 | 0.743 |
TGFBR2 |
0.734 | -0.016 | -2 | 0.787 |
ERK5 |
0.734 | -0.047 | 1 | 0.728 |
CAMK2A |
0.734 | 0.039 | 2 | 0.679 |
ALK2 |
0.734 | 0.087 | -2 | 0.754 |
NLK |
0.733 | -0.066 | 1 | 0.743 |
MST4 |
0.733 | -0.032 | 2 | 0.704 |
PDHK1 |
0.733 | -0.153 | 1 | 0.770 |
PIM1 |
0.733 | 0.007 | -3 | 0.754 |
CDKL1 |
0.732 | -0.034 | -3 | 0.766 |
MASTL |
0.732 | -0.084 | -2 | 0.715 |
NIK |
0.731 | -0.103 | -3 | 0.864 |
DNAPK |
0.731 | 0.024 | 1 | 0.697 |
BMPR1A |
0.731 | 0.100 | 1 | 0.668 |
PASK |
0.731 | 0.107 | -3 | 0.813 |
DRAK1 |
0.731 | 0.067 | 1 | 0.736 |
GRK2 |
0.731 | 0.044 | -2 | 0.666 |
BCKDK |
0.731 | -0.091 | -1 | 0.339 |
ANKRD3 |
0.731 | -0.023 | 1 | 0.793 |
LATS1 |
0.730 | 0.032 | -3 | 0.824 |
NUAK2 |
0.730 | -0.043 | -3 | 0.821 |
MEKK3 |
0.730 | 0.096 | 1 | 0.736 |
JNK3 |
0.729 | 0.034 | 1 | 0.577 |
CAMK2D |
0.728 | -0.061 | -3 | 0.818 |
ULK2 |
0.728 | -0.173 | 2 | 0.635 |
CAMLCK |
0.728 | -0.067 | -2 | 0.708 |
PKN2 |
0.728 | -0.037 | -3 | 0.823 |
PLK2 |
0.728 | 0.092 | -3 | 0.726 |
TTBK2 |
0.728 | -0.067 | 2 | 0.566 |
DAPK2 |
0.727 | -0.072 | -3 | 0.843 |
GAK |
0.727 | 0.221 | 1 | 0.837 |
YSK4 |
0.727 | -0.018 | 1 | 0.731 |
MARK4 |
0.726 | -0.085 | 4 | 0.739 |
RSK2 |
0.726 | -0.027 | -3 | 0.743 |
TLK2 |
0.726 | -0.018 | 1 | 0.708 |
CLK2 |
0.726 | 0.073 | -3 | 0.727 |
GRK3 |
0.726 | 0.067 | -2 | 0.636 |
WNK3 |
0.725 | -0.160 | 1 | 0.751 |
JNK2 |
0.725 | 0.026 | 1 | 0.554 |
PLK4 |
0.725 | -0.012 | 2 | 0.540 |
ULK1 |
0.725 | -0.130 | -3 | 0.792 |
SRPK1 |
0.725 | -0.014 | -3 | 0.717 |
NDR1 |
0.725 | -0.075 | -3 | 0.812 |
AMPKA1 |
0.724 | -0.080 | -3 | 0.837 |
CHAK2 |
0.724 | -0.105 | -1 | 0.353 |
CDK1 |
0.723 | 0.007 | 1 | 0.548 |
SRPK3 |
0.723 | 0.002 | -3 | 0.686 |
LATS2 |
0.723 | -0.073 | -5 | 0.552 |
P90RSK |
0.722 | -0.058 | -3 | 0.738 |
MEK1 |
0.722 | -0.071 | 2 | 0.697 |
RIPK1 |
0.721 | -0.134 | 1 | 0.736 |
TSSK2 |
0.721 | -0.084 | -5 | 0.626 |
GSK3A |
0.721 | 0.080 | 4 | 0.511 |
CDKL5 |
0.720 | -0.053 | -3 | 0.757 |
P70S6KB |
0.720 | -0.057 | -3 | 0.777 |
ICK |
0.720 | -0.072 | -3 | 0.801 |
MAPKAPK2 |
0.720 | -0.013 | -3 | 0.702 |
CK1E |
0.719 | 0.044 | -3 | 0.499 |
JNK1 |
0.719 | 0.039 | 1 | 0.533 |
NEK9 |
0.719 | -0.188 | 2 | 0.666 |
PKACG |
0.718 | -0.065 | -2 | 0.578 |
PKCD |
0.718 | -0.096 | 2 | 0.644 |
RSK4 |
0.718 | -0.016 | -3 | 0.711 |
SMG1 |
0.718 | -0.061 | 1 | 0.705 |
MYLK4 |
0.718 | -0.019 | -2 | 0.611 |
MLK3 |
0.718 | -0.073 | 2 | 0.607 |
CAMK4 |
0.718 | -0.079 | -3 | 0.807 |
MLK4 |
0.717 | -0.067 | 2 | 0.591 |
MLK2 |
0.717 | -0.155 | 2 | 0.648 |
MSK1 |
0.716 | -0.020 | -3 | 0.714 |
GSK3B |
0.716 | 0.056 | 4 | 0.501 |
PKR |
0.715 | -0.118 | 1 | 0.741 |
CLK4 |
0.715 | -0.017 | -3 | 0.742 |
VRK2 |
0.715 | -0.192 | 1 | 0.760 |
SRPK2 |
0.715 | -0.023 | -3 | 0.637 |
CDK8 |
0.715 | -0.060 | 1 | 0.583 |
AMPKA2 |
0.715 | -0.087 | -3 | 0.807 |
TSSK1 |
0.715 | -0.099 | -3 | 0.854 |
MAPKAPK3 |
0.715 | -0.081 | -3 | 0.754 |
RSK3 |
0.715 | -0.082 | -3 | 0.735 |
PRKD1 |
0.714 | -0.121 | -3 | 0.788 |
TLK1 |
0.714 | -0.041 | -2 | 0.820 |
PAK1 |
0.714 | -0.075 | -2 | 0.621 |
MSK2 |
0.713 | -0.063 | -3 | 0.699 |
NIM1 |
0.713 | -0.139 | 3 | 0.635 |
CK1D |
0.712 | 0.045 | -3 | 0.455 |
TAO3 |
0.712 | -0.047 | 1 | 0.737 |
MARK3 |
0.712 | -0.058 | 4 | 0.672 |
BRAF |
0.712 | -0.104 | -4 | 0.776 |
P38G |
0.712 | -0.010 | 1 | 0.473 |
CK1A2 |
0.711 | 0.051 | -3 | 0.453 |
IRE1 |
0.711 | -0.159 | 1 | 0.694 |
AURA |
0.711 | -0.033 | -2 | 0.480 |
BRSK1 |
0.711 | -0.060 | -3 | 0.775 |
P38B |
0.710 | -0.017 | 1 | 0.560 |
MEKK2 |
0.710 | -0.079 | 2 | 0.639 |
DYRK2 |
0.710 | -0.032 | 1 | 0.569 |
CAMK1G |
0.710 | -0.037 | -3 | 0.740 |
PKCG |
0.710 | -0.093 | 2 | 0.610 |
CLK1 |
0.710 | -0.025 | -3 | 0.731 |
MST3 |
0.710 | -0.027 | 2 | 0.698 |
NEK11 |
0.710 | -0.032 | 1 | 0.760 |
PRKD2 |
0.710 | -0.091 | -3 | 0.753 |
QIK |
0.710 | -0.127 | -3 | 0.819 |
CDK2 |
0.710 | -0.052 | 1 | 0.620 |
HRI |
0.710 | -0.106 | -2 | 0.821 |
P38A |
0.709 | -0.041 | 1 | 0.633 |
GCK |
0.709 | 0.012 | 1 | 0.777 |
ZAK |
0.709 | -0.126 | 1 | 0.696 |
MEK5 |
0.708 | -0.144 | 2 | 0.671 |
HIPK4 |
0.708 | -0.107 | 1 | 0.652 |
AURC |
0.708 | -0.060 | -2 | 0.492 |
MARK2 |
0.708 | -0.080 | 4 | 0.637 |
PRKX |
0.708 | -0.001 | -3 | 0.669 |
PKCB |
0.707 | -0.094 | 2 | 0.596 |
PAK2 |
0.707 | -0.100 | -2 | 0.601 |
TTBK1 |
0.707 | -0.080 | 2 | 0.516 |
NEK5 |
0.707 | -0.131 | 1 | 0.776 |
MARK1 |
0.707 | -0.077 | 4 | 0.696 |
PKACB |
0.707 | -0.033 | -2 | 0.514 |
CHK1 |
0.707 | -0.120 | -3 | 0.804 |
DYRK4 |
0.707 | 0.021 | 1 | 0.514 |
DCAMKL1 |
0.707 | -0.062 | -3 | 0.770 |
MST2 |
0.706 | -0.014 | 1 | 0.767 |
SGK3 |
0.706 | -0.062 | -3 | 0.744 |
CDK19 |
0.706 | -0.060 | 1 | 0.552 |
ERK2 |
0.706 | -0.056 | 1 | 0.594 |
QSK |
0.706 | -0.099 | 4 | 0.708 |
PKCA |
0.706 | -0.107 | 2 | 0.594 |
DCAMKL2 |
0.706 | -0.053 | -3 | 0.800 |
NUAK1 |
0.706 | -0.109 | -3 | 0.781 |
ERK1 |
0.706 | -0.039 | 1 | 0.564 |
AURB |
0.706 | -0.064 | -2 | 0.492 |
IRE2 |
0.705 | -0.154 | 2 | 0.598 |
CDK7 |
0.705 | -0.074 | 1 | 0.598 |
P38D |
0.705 | -0.000 | 1 | 0.506 |
CDK5 |
0.705 | -0.058 | 1 | 0.617 |
NEK2 |
0.705 | -0.178 | 2 | 0.630 |
CDK3 |
0.705 | -0.011 | 1 | 0.502 |
PERK |
0.705 | -0.119 | -2 | 0.808 |
WNK4 |
0.704 | -0.135 | -2 | 0.751 |
MEKK1 |
0.704 | -0.161 | 1 | 0.739 |
MNK1 |
0.704 | -0.094 | -2 | 0.637 |
BRSK2 |
0.704 | -0.100 | -3 | 0.806 |
PAK3 |
0.704 | -0.136 | -2 | 0.615 |
MNK2 |
0.704 | -0.120 | -2 | 0.631 |
PIM2 |
0.704 | -0.043 | -3 | 0.726 |
SIK |
0.704 | -0.097 | -3 | 0.746 |
PKCZ |
0.704 | -0.134 | 2 | 0.618 |
IRAK1 |
0.703 | -0.146 | -1 | 0.299 |
TAK1 |
0.703 | 0.013 | 1 | 0.778 |
PDK1 |
0.703 | -0.047 | 1 | 0.771 |
PKCH |
0.703 | -0.118 | 2 | 0.588 |
ALPHAK3 |
0.702 | 0.079 | -1 | 0.383 |
CDK13 |
0.702 | -0.071 | 1 | 0.576 |
NEK8 |
0.702 | -0.113 | 2 | 0.663 |
AKT2 |
0.702 | -0.043 | -3 | 0.667 |
CHAK1 |
0.702 | -0.191 | 2 | 0.589 |
BMPR2_TYR |
0.702 | 0.370 | -1 | 0.513 |
MELK |
0.702 | -0.128 | -3 | 0.794 |
CK1G1 |
0.702 | -0.022 | -3 | 0.508 |
SMMLCK |
0.702 | -0.065 | -3 | 0.797 |
PHKG1 |
0.701 | -0.113 | -3 | 0.803 |
MPSK1 |
0.701 | -0.044 | 1 | 0.756 |
CDK18 |
0.701 | -0.054 | 1 | 0.539 |
PRP4 |
0.700 | -0.054 | -3 | 0.717 |
EEF2K |
0.699 | -0.065 | 3 | 0.698 |
CDK17 |
0.699 | -0.049 | 1 | 0.482 |
DAPK1 |
0.699 | -0.005 | -3 | 0.757 |
MST1 |
0.699 | -0.048 | 1 | 0.749 |
HPK1 |
0.699 | -0.016 | 1 | 0.772 |
PAK6 |
0.699 | -0.071 | -2 | 0.533 |
SNRK |
0.698 | -0.144 | 2 | 0.562 |
PKG2 |
0.698 | -0.081 | -2 | 0.507 |
TAO2 |
0.698 | -0.116 | 2 | 0.686 |
PRKD3 |
0.698 | -0.106 | -3 | 0.728 |
DAPK3 |
0.697 | -0.036 | -3 | 0.779 |
PINK1 |
0.696 | -0.165 | 1 | 0.738 |
IRAK4 |
0.696 | -0.184 | 1 | 0.721 |
CAMKK1 |
0.696 | -0.161 | -2 | 0.648 |
CDK14 |
0.695 | -0.050 | 1 | 0.590 |
CAMK1D |
0.695 | -0.057 | -3 | 0.679 |
CDK12 |
0.695 | -0.073 | 1 | 0.550 |
MAPKAPK5 |
0.695 | -0.127 | -3 | 0.673 |
HIPK2 |
0.695 | -0.042 | 1 | 0.497 |
PDHK4_TYR |
0.695 | 0.243 | 2 | 0.742 |
CDK9 |
0.694 | -0.086 | 1 | 0.586 |
PDHK1_TYR |
0.694 | 0.246 | -1 | 0.444 |
MINK |
0.694 | -0.084 | 1 | 0.765 |
HIPK1 |
0.694 | -0.059 | 1 | 0.597 |
MAP2K6_TYR |
0.694 | 0.236 | -1 | 0.427 |
CDK16 |
0.694 | -0.038 | 1 | 0.503 |
SSTK |
0.693 | -0.092 | 4 | 0.709 |
DYRK1A |
0.693 | -0.067 | 1 | 0.639 |
DYRK1B |
0.692 | -0.044 | 1 | 0.562 |
CDK10 |
0.692 | -0.033 | 1 | 0.577 |
PHKG2 |
0.691 | -0.092 | -3 | 0.797 |
PKACA |
0.691 | -0.050 | -2 | 0.463 |
MAP3K15 |
0.691 | -0.139 | 1 | 0.703 |
AKT1 |
0.691 | -0.062 | -3 | 0.688 |
TNIK |
0.691 | -0.099 | 3 | 0.668 |
PDHK3_TYR |
0.690 | 0.107 | 4 | 0.823 |
KHS2 |
0.690 | -0.040 | 1 | 0.775 |
ERK7 |
0.689 | -0.060 | 2 | 0.425 |
PTK2 |
0.689 | 0.300 | -1 | 0.600 |
VRK1 |
0.689 | -0.142 | 2 | 0.711 |
TTK |
0.688 | 0.023 | -2 | 0.824 |
CAMKK2 |
0.688 | -0.178 | -2 | 0.636 |
SLK |
0.688 | -0.085 | -2 | 0.600 |
LRRK2 |
0.688 | -0.181 | 2 | 0.684 |
LKB1 |
0.688 | -0.171 | -3 | 0.808 |
NEK4 |
0.687 | -0.192 | 1 | 0.752 |
P70S6K |
0.687 | -0.094 | -3 | 0.682 |
HGK |
0.687 | -0.144 | 3 | 0.666 |
KHS1 |
0.687 | -0.078 | 1 | 0.760 |
PBK |
0.685 | 0.008 | 1 | 0.801 |
STK33 |
0.685 | -0.129 | 2 | 0.532 |
SGK1 |
0.685 | -0.040 | -3 | 0.580 |
MRCKA |
0.685 | -0.057 | -3 | 0.742 |
RIPK2 |
0.685 | -0.144 | 1 | 0.695 |
PKCT |
0.685 | -0.147 | 2 | 0.588 |
YANK3 |
0.685 | -0.024 | 2 | 0.372 |
DYRK3 |
0.684 | -0.059 | 1 | 0.585 |
CK1A |
0.684 | 0.041 | -3 | 0.368 |
FYN |
0.684 | 0.266 | -1 | 0.499 |
PKCE |
0.684 | -0.086 | 2 | 0.596 |
MAP2K4_TYR |
0.684 | 0.050 | -1 | 0.396 |
HIPK3 |
0.683 | -0.095 | 1 | 0.616 |
MEKK6 |
0.683 | -0.191 | 1 | 0.720 |
PKCI |
0.682 | -0.137 | 2 | 0.598 |
NEK1 |
0.682 | -0.197 | 1 | 0.745 |
BIKE |
0.682 | 0.069 | 1 | 0.784 |
MAP2K7_TYR |
0.682 | 0.003 | 2 | 0.714 |
PAK5 |
0.681 | -0.097 | -2 | 0.475 |
LOK |
0.681 | -0.152 | -2 | 0.635 |
PAK4 |
0.681 | -0.087 | -2 | 0.483 |
OSR1 |
0.680 | -0.069 | 2 | 0.639 |
EPHA6 |
0.680 | 0.151 | -1 | 0.470 |
MRCKB |
0.680 | -0.064 | -3 | 0.730 |
ROCK2 |
0.680 | -0.071 | -3 | 0.770 |
SYK |
0.680 | 0.261 | -1 | 0.544 |
CDK6 |
0.679 | -0.070 | 1 | 0.578 |
CHK2 |
0.679 | -0.069 | -3 | 0.615 |
DMPK1 |
0.679 | -0.027 | -3 | 0.751 |
MEK2 |
0.679 | -0.215 | 2 | 0.645 |
EPHA4 |
0.678 | 0.109 | 2 | 0.707 |
TESK1_TYR |
0.677 | -0.079 | 3 | 0.726 |
PINK1_TYR |
0.676 | -0.033 | 1 | 0.745 |
PKN1 |
0.676 | -0.095 | -3 | 0.703 |
TXK |
0.676 | 0.114 | 1 | 0.732 |
YSK1 |
0.675 | -0.166 | 2 | 0.638 |
MAK |
0.675 | -0.036 | -2 | 0.617 |
FLT1 |
0.675 | 0.154 | -1 | 0.480 |
EPHB4 |
0.675 | 0.045 | -1 | 0.396 |
CAMK1A |
0.675 | -0.082 | -3 | 0.641 |
LCK |
0.674 | 0.182 | -1 | 0.470 |
AKT3 |
0.674 | -0.063 | -3 | 0.595 |
INSRR |
0.674 | 0.044 | 3 | 0.603 |
BLK |
0.674 | 0.179 | -1 | 0.463 |
HASPIN |
0.673 | -0.087 | -1 | 0.267 |
YES1 |
0.673 | 0.033 | -1 | 0.368 |
ITK |
0.673 | 0.078 | -1 | 0.397 |
CK1G2 |
0.672 | 0.095 | -3 | 0.423 |
PKMYT1_TYR |
0.672 | -0.123 | 3 | 0.681 |
HCK |
0.672 | 0.113 | -1 | 0.441 |
SRMS |
0.671 | 0.042 | 1 | 0.747 |
BMX |
0.671 | 0.062 | -1 | 0.360 |
SBK |
0.671 | -0.053 | -3 | 0.548 |
CDK4 |
0.670 | -0.085 | 1 | 0.534 |
EPHB2 |
0.670 | 0.063 | -1 | 0.399 |
EPHB1 |
0.669 | 0.044 | 1 | 0.741 |
FGR |
0.669 | 0.001 | 1 | 0.798 |
FER |
0.669 | -0.040 | 1 | 0.773 |
ASK1 |
0.669 | -0.153 | 1 | 0.689 |
JAK3 |
0.669 | 0.044 | 1 | 0.702 |
CK1G3 |
0.667 | 0.022 | -3 | 0.328 |
SRC |
0.666 | 0.114 | -1 | 0.424 |
RET |
0.666 | -0.117 | 1 | 0.721 |
EPHB3 |
0.666 | 0.027 | -1 | 0.388 |
MOK |
0.666 | -0.073 | 1 | 0.608 |
MET |
0.665 | 0.053 | 3 | 0.581 |
KIT |
0.665 | -0.006 | 3 | 0.598 |
ROCK1 |
0.665 | -0.081 | -3 | 0.738 |
MYO3A |
0.665 | -0.133 | 1 | 0.714 |
STLK3 |
0.665 | -0.109 | 1 | 0.677 |
AAK1 |
0.665 | 0.076 | 1 | 0.716 |
CRIK |
0.664 | -0.066 | -3 | 0.680 |
DDR1 |
0.664 | -0.110 | 4 | 0.764 |
FGFR2 |
0.664 | -0.044 | 3 | 0.651 |
EPHA3 |
0.664 | 0.027 | 2 | 0.672 |
FGFR3 |
0.664 | 0.021 | 3 | 0.636 |
KDR |
0.663 | -0.002 | 3 | 0.579 |
YANK2 |
0.663 | -0.026 | 2 | 0.382 |
CSF1R |
0.663 | -0.083 | 3 | 0.591 |
ERBB2 |
0.662 | 0.016 | 1 | 0.674 |
MST1R |
0.662 | -0.117 | 3 | 0.607 |
EPHA5 |
0.662 | 0.058 | 2 | 0.694 |
TYK2 |
0.662 | -0.171 | 1 | 0.728 |
EPHA2 |
0.661 | 0.124 | -1 | 0.452 |
TAO1 |
0.661 | -0.157 | 1 | 0.682 |
LYN |
0.661 | 0.081 | 3 | 0.518 |
EGFR |
0.661 | 0.030 | 1 | 0.581 |
EPHA7 |
0.660 | 0.036 | 2 | 0.692 |
ABL2 |
0.660 | -0.079 | -1 | 0.353 |
TYRO3 |
0.660 | -0.178 | 3 | 0.596 |
EPHA8 |
0.659 | 0.094 | -1 | 0.455 |
LIMK2_TYR |
0.659 | -0.195 | -3 | 0.875 |
ERBB4 |
0.659 | 0.109 | 1 | 0.595 |
LIMK1_TYR |
0.659 | -0.235 | 2 | 0.685 |
MYO3B |
0.659 | -0.177 | 2 | 0.638 |
JAK2 |
0.658 | -0.151 | 1 | 0.721 |
BTK |
0.658 | -0.083 | -1 | 0.327 |
BUB1 |
0.658 | -0.143 | -5 | 0.559 |
TEC |
0.658 | -0.058 | -1 | 0.297 |
NEK3 |
0.657 | -0.268 | 1 | 0.707 |
ROS1 |
0.656 | -0.192 | 3 | 0.572 |
NTRK1 |
0.656 | -0.095 | -1 | 0.362 |
FGFR4 |
0.656 | -0.008 | -1 | 0.356 |
FRK |
0.655 | 0.019 | -1 | 0.426 |
MERTK |
0.655 | -0.103 | 3 | 0.593 |
INSR |
0.655 | -0.076 | 3 | 0.566 |
ZAP70 |
0.655 | 0.118 | -1 | 0.481 |
FLT4 |
0.655 | -0.045 | 3 | 0.596 |
PKG1 |
0.654 | -0.113 | -2 | 0.424 |
ABL1 |
0.654 | -0.118 | -1 | 0.338 |
TNK2 |
0.654 | -0.128 | 3 | 0.559 |
FLT3 |
0.653 | -0.110 | 3 | 0.579 |
FGFR1 |
0.652 | -0.133 | 3 | 0.598 |
IGF1R |
0.652 | -0.009 | 3 | 0.520 |
NEK10_TYR |
0.651 | -0.134 | 1 | 0.668 |
TEK |
0.651 | -0.098 | 3 | 0.553 |
WEE1_TYR |
0.651 | -0.110 | -1 | 0.307 |
PDGFRB |
0.650 | -0.203 | 3 | 0.601 |
PTK2B |
0.649 | -0.060 | -1 | 0.295 |
PTK6 |
0.649 | -0.163 | -1 | 0.289 |
NTRK3 |
0.648 | -0.106 | -1 | 0.336 |
CSK |
0.648 | -0.069 | 2 | 0.685 |
NTRK2 |
0.647 | -0.149 | 3 | 0.574 |
AXL |
0.647 | -0.185 | 3 | 0.591 |
LTK |
0.646 | -0.152 | 3 | 0.569 |
DDR2 |
0.646 | -0.070 | 3 | 0.600 |
ALK |
0.645 | -0.163 | 3 | 0.546 |
MATK |
0.645 | -0.099 | -1 | 0.312 |
EPHA1 |
0.644 | -0.090 | 3 | 0.551 |
JAK1 |
0.642 | -0.162 | 1 | 0.693 |
TNK1 |
0.640 | -0.227 | 3 | 0.573 |
PDGFRA |
0.640 | -0.241 | 3 | 0.586 |
FES |
0.637 | -0.050 | -1 | 0.319 |
TNNI3K_TYR |
0.635 | -0.236 | 1 | 0.689 |
MUSK |
0.627 | -0.124 | 1 | 0.592 |